[Hub]/) : Traits : Diastolic blood pressure, automated reading : ← →

chr16:29,850,705-31,860,399

Best TWAS P=4.4e-13 · Best GWAS P=3.98e-10 conditioned to 0.405

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RNF40	0.14	0.15	enet	7	0.15	1.9e-17	5.4	5.4	6.7e-08	-0.33	0.44	0.56	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SETD1A	0.04	0.03	bslmm	243	0.02	3.9e-03	4.0	5.5	4.6e-08	-0.71	0.09	0.61	FALSE
3	CommonMind	Brain Pre-frontal Cortex	VKORC1	0.03	0.04	lasso	3	0.03	4.9e-05	-5.2	-5.5	4.9e-08	0.80	0.22	0.32	FALSE
4	CommonMind	Brain Pre-frontal Cortex	ZNF646	0.04	0.06	lasso	7	0.04	4.5e-06	-5.4	5.6	1.6e-08	-0.88	0.05	0.94	FALSE
5	GTEx	Adipose Subcutaneous	STX4	0.06	0.05	lasso	2	0.02	7.8e-03	5.6	5.7	1.3e-08	-0.36	0.08	0.64	FALSE
6	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	5.2	5.8	6.1e-09	-0.66	0.60	0.40	FALSE
7	GTEx	Adipose Subcutaneous	RNF40	0.18	0.10	lasso	7	0.11	3.7e-09	5.4	5.7	1.2e-08	-0.26	0.38	0.62	FALSE
8	GTEx	Adipose Visceral Omentum	KAT8	0.07	0.02	lasso	5	0.02	4.0e-02	-5.2	5.5	3.0e-08	-0.80	0.12	0.69	FALSE
9	GTEx	Adrenal Gland	KAT8	0.11	0.06	enet	11	0.07	1.8e-03	-5.5	5.5	4.9e-08	-0.85	0.09	0.66	FALSE
10	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	-5.2	6.2	6.0e-10	-0.82	0.18	0.82	FALSE
11	GTEx	Artery Tibial	KAT8	0.30	0.23	lasso	5	0.27	3.3e-21	5.2	6.3	3.9e-10	-0.67	0.56	0.44	FALSE
12	GTEx	Brain Caudate basal ganglia	PRSS36	0.16	0.25	lasso	3	0.23	2.4e-07	5.2	5.3	9.0e-08	-0.38	0.17	0.57	FALSE
13	GTEx	Brain Cerebellar Hemisphere	KAT8	0.12	0.23	lasso	3	0.18	2.9e-05	-5.2	5.4	8.7e-08	-0.86	0.09	0.61	FALSE
14	GTEx	Brain Cerebellum	KAT8	0.21	0.01	lasso	9	0.05	1.4e-02	-5.3	6.5	7.3e-11	-0.71	0.14	0.50	FALSE
15	GTEx	Brain Cerebellum	RNF40	0.24	0.16	lasso	5	0.13	9.7e-05	5.4	5.3	1.4e-07	-0.28	0.17	0.36	FALSE
16	GTEx	Brain Cortex	KAT8	0.14	0.14	lasso	3	0.10	8.9e-04	-5.1	5.8	6.1e-09	-0.96	0.03	0.84	FALSE
17	GTEx	Brain Frontal Cortex BA9	KAT8	0.16	0.20	lasso	1	0.17	2.6e-05	-5.3	5.3	9.0e-08	-0.85	0.11	0.62	FALSE
18	GTEx	Brain Frontal Cortex BA9	C16orf93	0.25	0.13	enet	16	0.23	8.3e-07	-3.0	-6.0	1.7e-09	0.42	0.09	0.56	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	-5.3	6.1	1.3e-09	-0.73	0.09	0.42	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	PRSS36	0.40	0.28	lasso	2	0.26	1.6e-07	5.2	5.2	1.6e-07	-0.37	0.32	0.41	FALSE
21	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	-5.3	5.8	6.9e-09	-0.73	0.51	0.48	FALSE
22	GTEx	Breast Mammary Tissue (Male)	AC002310.12	0.20	0.10	lasso	2	0.08	7.0e-03	5.5	-5.7	1.0e-08	0.19	0.02	0.29	FALSE
23	GTEx	Cells Transformed fibroblasts	KAT8	0.31	0.31	lasso	4	0.32	1.9e-24	5.2	5.7	1.6e-08	-0.48	0.57	0.43	FALSE
24	GTEx	Cells Transformed fibroblasts	RNF40	0.08	0.04	lasso	8	0.04	5.6e-04	5.4	6.1	8.4e-10	-0.45	0.04	0.93	FALSE
25	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	-5.2	6.1	8.9e-10	-0.73	0.10	0.68	FALSE
26	GTEx	Colon Transverse	STX1B	0.12	0.01	lasso	5	0.00	3.9e-01	5.6	5.6	2.6e-08	-0.48	0.06	0.22	FALSE
27	GTEx	Colon Transverse	KAT8	0.14	0.12	lasso	6	0.05	1.4e-03	5.2	6.1	1.1e-09	-0.50	0.14	0.60	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	5.2	6.2	4.2e-10	-0.76	0.12	0.87	FALSE
29	GTEx	Esophagus Mucosa	BCKDK	0.05	0.05	enet	6	0.06	8.7e-05	-5.3	-5.6	1.8e-08	0.86	0.08	0.83	FALSE
30	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	5.2	6.4	1.8e-10	-0.72	0.36	0.64	FALSE
31	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	5.2	6.1	1.4e-09	-0.64	0.53	0.47	FALSE
32	GTEx	Esophagus Muscularis	RNF40	0.16	0.10	lasso	1	0.08	1.3e-05	5.3	5.3	9.6e-08	-0.35	0.25	0.56	FALSE
33	GTEx	Liver	PRSS53	0.22	0.08	lasso	5	0.11	5.5e-04	-6.3	6.3	3.9e-10	-0.90	0.02	0.91	TRUE
34	GTEx	Liver	VKORC1	0.22	0.20	lasso	5	0.22	1.1e-06	-5.3	5.7	1.4e-08	-0.92	0.06	0.93	FALSE
35	GTEx	Liver	PRSS36	0.13	0.03	enet	34	0.04	2.2e-02	6.1	6.2	7.5e-10	-0.65	0.04	0.67	FALSE
36	GTEx	Lung	KAT8	0.14	0.08	lasso	3	0.12	1.7e-09	-5.3	6.3	2.4e-10	-0.72	0.48	0.51	FALSE
37	GTEx	Muscle Skeletal	KAT8	0.08	0.04	enet	16	0.06	1.4e-06	6.2	6.0	2.1e-09	-0.63	0.02	0.98	FALSE
38	GTEx	Nerve Tibial	BCKDK	0.07	0.02	lasso	7	0.04	1.0e-03	-3.9	-5.4	6.8e-08	0.49	0.08	0.56	FALSE
39	GTEx	Nerve Tibial	KAT8	0.17	0.06	enet	24	0.08	3.0e-06	5.2	6.4	2.1e-10	-0.72	0.42	0.56	FALSE
40	GTEx	Nerve Tibial	RNF40	0.13	0.08	lasso	5	0.09	8.1e-07	5.5	5.8	8.1e-09	-0.25	0.34	0.66	FALSE
41	GTEx	Ovary	STX4	0.16	0.05	enet	13	0.07	9.0e-03	4.4	5.6	1.6e-08	-0.56	0.06	0.51	FALSE
42	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	-5.2	6.0	2.4e-09	-0.79	0.07	0.53	FALSE
43	GTEx	Ovary	C16orf93	0.13	0.06	lasso	8	0.09	3.4e-03	5.6	-5.8	5.0e-09	0.54	0.07	0.36	FALSE
44	GTEx	Pituitary	KAT8	0.18	0.10	lasso	3	0.13	4.4e-04	5.2	5.3	1.2e-07	-0.38	0.14	0.60	FALSE
45	GTEx	Pituitary	C16orf93	0.10	0.00	enet	14	0.00	2.4e-01	5.4	-5.4	6.1e-08	0.64	0.04	0.38	FALSE
46	GTEx	Prostate	KAT8	0.19	0.09	lasso	3	0.13	3.8e-04	-5.2	6.3	3.4e-10	-0.81	0.05	0.50	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	5.2	6.2	6.5e-10	-0.72	0.47	0.53	FALSE
48	GTEx	Skin Sun Exposed Lower leg	STX4	0.04	0.02	enet	18	0.04	3.9e-04	3.9	5.3	1.1e-07	-0.45	0.30	0.32	FALSE
49	GTEx	Skin Sun Exposed Lower leg	BCKDK	0.05	0.01	enet	11	0.03	2.6e-03	2.9	-5.4	6.2e-08	0.48	0.16	0.37	FALSE
50	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	-5.3	6.0	1.8e-09	-0.72	0.54	0.46	FALSE
51	GTEx	Small Intestine Terminal Ileum	VKORC1	0.30	0.05	enet	18	0.12	1.4e-03	-5.9	5.9	4.1e-09	-0.69	0.04	0.30	FALSE
52	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	5.2	6.7	1.5e-11	-0.72	0.05	0.93	FALSE
53	GTEx	Testis	C16orf93	0.10	0.09	lasso	3	0.08	1.4e-04	5.3	-5.6	2.6e-08	0.42	0.25	0.52	FALSE
54	GTEx	Thyroid	HSD3B7	0.27	0.12	lasso	4	0.17	7.0e-13	4.2	5.4	5.6e-08	-0.55	0.65	0.35	FALSE
55	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	-5.3	6.4	1.9e-10	-0.77	0.47	0.53	FALSE
56	GTEx	Thyroid	RNF40	0.07	0.03	lasso	3	0.03	1.5e-03	5.4	6.0	2.0e-09	-0.46	0.03	0.93	FALSE
57	GTEx	Thyroid	C16orf93	0.17	0.18	lasso	4	0.18	1.6e-13	5.4	-5.5	4.3e-08	0.38	0.36	0.63	FALSE
58	GTEx	Vagina	KAT8	0.34	0.26	lasso	5	0.22	8.4e-06	5.2	5.5	5.0e-08	-0.40	0.10	0.35	FALSE
59	GTEx	Whole Blood	HSD3B7	0.06	0.06	lasso	4	0.06	2.6e-06	-5.9	-5.8	7.9e-09	0.91	0.11	0.89	FALSE
60	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	-5.3	-5.9	4.8e-09	0.79	0.28	0.71	FALSE
61	METSIM	Adipose	KAT8	0.17	0.13	lasso	6	0.20	1.7e-28	-5.3	6.1	9.2e-10	-0.70	0.58	0.42	FALSE
62	METSIM	Adipose	RNF40	0.12	0.07	lasso	4	0.07	1.1e-10	5.4	5.7	1.6e-08	-0.29	0.40	0.60	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	3.4	5.8	5.6e-09	-0.73	0.11	0.73	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	-5.3	6.0	1.9e-09	-0.81	0.49	0.51	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	ZNF689	0.06	0.06	lasso	3	0.06	1.8e-08	5.0	-5.1	3.0e-07	0.46	0.74	0.26	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	ZNF668	0.11	0.11	lasso	4	0.11	1.7e-14	-5.3	-5.2	2.6e-07	0.88	0.32	0.68	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	ZNF646	0.06	0.01	bslmm	233	0.01	1.1e-02	-5.5	5.4	7.1e-08	-0.79	0.07	0.91	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	PRSS36	0.14	0.12	bslmm	241	0.12	1.1e-15	5.2	5.3	1.2e-07	-0.47	0.57	0.43	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	C16orf93	0.19	0.26	lasso	10	0.28	5.1e-36	5.5	-5.9	3.9e-09	0.48	0.38	0.62	FALSE
70	YFS	Blood	HSD3B7	0.06	0.02	blup	220	0.03	8.9e-10	-5.3	-5.7	9.3e-09	0.65	0.33	0.66	FALSE
71	YFS	Blood	PRSS36	0.02	0.02	enet	8	0.02	1.1e-07	5.2	5.7	1.3e-08	-0.41	0.49	0.49	FALSE
72	YFS	Blood	ZNF668	0.10	0.12	bslmm	232	0.12	1.5e-36	-5.3	-5.3	9.3e-08	0.88	0.30	0.70	FALSE
73	YFS	Blood	ZNF785	0.05	0.07	lasso	4	0.06	2.0e-20	4.7	5.5	4.2e-08	-0.36	0.96	0.04	FALSE
74	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	5.2	6.0	2.6e-09	-0.62	0.03	0.80	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD3B7	0.03	0.03	blup	31	0.04	5.2e-08	4.7	5.7	1.0e-08	-0.66	0.63	0.37	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	5.2	5.7	1.1e-08	-0.66	0.04	0.96	FALSE
77	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MYST1	0.26	0.01	blup	34	0.05	1.4e-03	-5.1	6.1	7.8e-10	-0.65	0.01	0.48	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	4.8	7.0	2.3e-12	-0.75	0.03	0.83	FALSE
79	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF668	0.03	0.01	lasso	3	0.01	2.5e-02	-5.3	-5.6	2.5e-08	0.88	0.01	0.90	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf93	0.02	0.02	blup	11	0.02	1.5e-03	5.3	-6.3	2.8e-10	0.36	0.00	0.68	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYST1	0.12	0.09	blup	34	0.10	2.8e-11	5.2	6.1	1.4e-09	-0.63	0.03	0.97	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VKORC1	0.03	0.04	lasso	3	0.04	3.2e-05	-5.4	5.4	5.3e-08	-0.89	0.02	0.98	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	-5.5	-5.9	3.9e-09	0.86	0.01	0.95	FALSE
84	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf93	0.14	0.11	blup	10	0.11	4.5e-07	5.3	-6.4	1.2e-10	0.46	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYST1	0.07	0.01	enet	6	0.04	1.6e-03	-5.3	5.8	7.8e-09	-0.77	0.02	0.86	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf93	0.09	0.09	blup	11	0.09	1.0e-10	5.4	-7.2	4.4e-13	0.42	0.00	1.00	TRUE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	-5.3	6.1	9.4e-10	-0.70	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	-5.3	-5.4	5.4e-08	0.82	0.02	0.82	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	MYST1	0.09	0.03	blup	33	0.03	1.4e-04	5.2	5.5	4.3e-08	-0.51	0.03	0.91	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYST1	0.08	0.08	enet	8	0.08	2.8e-09	5.2	5.4	6.5e-08	-0.45	0.03	0.97	FALSE
91	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	4.2	5.9	3.1e-09	-0.74	0.07	0.50	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	-5.3	5.7	1.4e-08	-0.85	0.02	0.91	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	4.3	5.1	2.7e-07	-0.73	0.02	0.42	FALSE
94	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	-5.3	5.9	3.7e-09	-0.75	0.02	0.98	FALSE
95	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MYST1	0.07	0.09	lasso	3	0.07	1.0e-03	5.2	5.9	3.8e-09	-0.55	0.02	0.71	FALSE
96	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	-5.3	6.1	8.3e-10	-0.76	0.02	0.98	FALSE
97	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS36	0.17	0.13	blup	27	0.14	1.0e-14	5.2	5.2	1.7e-07	-0.57	0.03	0.97	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNF40	0.07	0.11	lasso	5	0.10	7.5e-11	5.3	5.4	7.9e-08	-0.34	0.01	0.99	FALSE
99	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	-5.3	6.1	1.4e-09	-0.83	0.01	0.61	FALSE
100	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	5.2	5.8	8.1e-09	-0.69	0.02	0.55	FALSE
101	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	-5.1	6.3	2.4e-10	-0.81	0.02	0.94	FALSE
102	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PRR14	0.08	0.05	blup	10	0.02	5.6e-02	4.9	-5.1	2.8e-07	0.43	0.00	0.42	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf93	0.15	0.19	lasso	4	0.19	1.8e-18	5.3	-5.6	2.3e-08	0.37	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	-5.3	6.1	1.4e-09	-0.72	0.03	0.97	FALSE