TWAS hub - ZNF689

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.064	0.0244	2.0e-05	0.064	0.043	0.057	0.045	0.062	1.1e-08	3.0e-06	7.9e-08	1.7e-06	1.8e-08
2	YFS	Blood	0.064	0.0182	4.8e-12	0.044	0.046	0.058	0.053	0.059	2.4e-14	6.2e-15	1.8e-18	5.3e-17	1.7e-18

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Bendroflumethiazide	14.9	22.6	22.9	-4.7	-4.8
Alcohol intake frequency.	9.8	22.8	24.4	-4.9	-4.6
Waist circumference	9.6	35.0	38.6	-6.2	-5.6
Hip circumference	9.4	40.7	43.4	-6.6	-6.2
Weight	8.6	42.3	46.0	-6.8	-6.2
Rheumatoid Arthritis	8.2	11.2	13.2	-3.6	-3.0
Body mass index (BMI)	8.2	34.7	34.8	-5.9	-5.9
Arm fat mass (right)	8.1	33.3	35.9	-6.0	-5.5
Arm fat mass (left)	8.0	32.7	36.2	-6.0	-5.4
Leg fat mass (left)	7.7	30.1	32.4	-5.7	-5.3
Medication: Atorvastatin	7.3	9.0	11.1	-3.3	-2.6
Leg fat mass (right)	6.9	26.9	29.3	-5.4	-5.0
Whole body fat mass	6.7	27.9	30.8	-5.5	-5.0
Alzheimer’s Disease (including proxy)	6.6	9.6	12.7	3.6	2.5
Pain all over the body in last month	6.6	7.1	8.9	-3.0	-2.3
Financial difficulties in last 2 years	6.4	8.6	9.0	-3.0	-2.9
Vascular/heart problems diagnosed by doctor	6.3	17.2	18.7	4.3	4.0
Leg fat-free mass (right)	6.2	33.1	35.9	-6.0	-5.5
Arm fat percentage (left)	6.2	24.5	28.7	-5.4	-4.5
Blood White Count	6.1	45.3	48.0	6.9	6.5
High blood pressure	6.1	17.0	19.0	-4.4	-3.9
Leg predicted mass (right)	6.1	32.7	35.4	-6.0	-5.5
Diastolic blood pressure, automated reading	6.1	18.9	26.3	-5.1	-3.4
Arm fat percentage (right)	6.0	23.8	26.8	-5.2	-4.5
Basal metabolic rate	6.0	33.3	34.8	-5.9	-5.6
Leg fat-free mass (left)	5.9	31.2	33.5	-5.8	-5.4
Comparative body size at age 10	5.9	16.4	19.5	-4.4	-3.6
Leg predicted mass (left)	5.7	30.0	32.4	-5.7	-5.2
Trunk fat mass	5.7	24.5	28.5	-5.3	-4.5
BMI	5.6	32.6	32.8	-5.7	-5.7
Arm predicted mass (left)	5.6	28.7	29.1	-5.3	-5.4
Suffer from ‘nerves’	5.5	8.6	10.7	3.3	2.6
Arm predicted mass (right)	5.4	27.6	28.6	-5.3	-5.2
Blood Eosinophil Count	5.3	40.6	49.0	7.0	5.7
Arm fat-free mass (right)	5.3	27.3	27.8	-5.3	-5.2
Medication: Co-codamol	5.2	6.0	6.4	-2.4	-2.5
Arm fat-free mass (left)	5.2	26.3	26.4	-5.1	-5.1
Alzheimer’s Disease (in mother)	5.1	6.0	7.2	2.7	2.2
Whole body fat-free mass	5.1	28.9	29.7	-5.5	-5.3
Leg fat percentage (left)	5.1	18.5	20.5	-4.5	-4.1
Hypertension (Self-reported)	5.0	13.8	15.7	-4.0	-3.5
Whole body water mass	5.0	28.7	29.3	-5.4	-5.3
Triglycerides	4.9	8.0	9.2	-3.0	-2.6
Nervous feelings	4.8	9.0	10.7	3.3	2.7
Body fat percentage	4.8	18.9	22.2	-4.7	-3.9
Impedance of leg (right)	4.7	22.7	24.7	4.6	5.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.7	10.0	10.7	3.3	3.0
Irritability	4.4	7.4	8.6	2.9	2.5
Trunk fat percentage	4.2	16.9	20.6	-4.5	-3.6
Cardiovascular Disease	4.0	13.1	15.6	-4.0	-3.3
Trunk fat-free mass	3.9	22.5	22.9	-4.7	-4.8
Trunk predicted mass	3.9	22.0	22.5	-4.7	-4.7
Heel T-Score	3.8	30.4	35.4	6.0	5.0
Lung FEV1/FVC ratio	3.8	19.4	23.5	4.9	3.9
Tense / ‘highly strung’	3.7	6.2	6.5	2.5	2.4
Leg fat percentage (right)	3.7	13.2	14.9	-3.9	-3.4
Unable to work because of sickness or disability	3.7	4.8	5.0	-2.2	-2.2
Impedance of whole body	3.7	19.0	24.2	3.7	4.9
Prostate Cancer	3.5	4.9	5.9	-2.4	-2.0
Medication: Blood pressure	3.5	6.2	6.5	-2.4	-2.5
Tinnitus: Yes, but not now, but have in the past	3.4	3.6	4.7	-2.2	-1.6
Pulse rate, automated reading	3.4	11.1	18.1	-4.3	-2.0
Age at last live birth	3.4	4.9	5.0	2.2	2.2
High cholesterol (Self-reported)	3.4	6.0	7.7	-2.8	-2.1
Medication: Blood pressure	3.3	6.3	7.6	-2.8	-2.2
Fasting Glucose	3.2	3.8	4.2	2.1	1.9
Average weekly fortified wine intake	3.2	3.8	4.5	1.7	2.1
Impedance of leg (left)	3.2	15.6	17.1	3.7	4.1
Pulse wave Arterial Stiffness index	3.2	3.8	4.6	-2.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	3.1	4.9	6.3	2.5	1.9
Primary Biliary Cirrhosis	3.0	4.3	5.2	-2.3	-1.9
Impedance of arm (right)	3.0	14.1	18.7	3.1	4.3
Hand grip strength (right)	2.9	7.8	10.4	-3.2	-2.3
Impedance of arm (left)	2.9	13.4	18.7	2.8	4.3
Medication for cholesterol	2.9	4.4	4.9	2.2	2.0
Number of self-reported non-cancer illnesses	2.9	5.1	5.9	-2.4	-2.1
Smoking status: Previous	2.8	4.2	5.2	2.3	1.8
Average weekly champagne plus white wine intake	2.8	3.8	5.1	2.3	1.6
Maternal smoking around birth	2.7	3.9	4.0	1.9	2.0
Number of incorrect matches in round	2.7	4.4	4.6	2.0	2.1
Ever smoked	2.7	4.8	6.1	2.5	1.9
Hand grip strength (left)	2.6	6.9	9.4	-3.1	-2.1
Past tobacco smoking	2.5	4.7	6.0	-2.5	-1.8
Exposure to tobacco smoke at home	2.5	2.8	4.2	-1.2	-2.1
Pulse wave peak to peak time	2.5	2.9	3.4	1.9	1.5
Worry (Nagel 2018)	2.4	5.1	6.3	2.5	2.0
Hayfever/allergic rhinitis (self-reported)	2.4	3.1	4.0	1.5	2.0
Supplements: Fish oil (including cod liver oil)	2.4	3.2	4.0	2.0	1.5
Age at First Birth	2.3	3.4	4.6	1.5	2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.3	5.6	2.3	2.4
Cholesterol lowering medication	2.2	3.2	4.5	-2.1	-1.4
Supplements: Calcium	2.2	2.4	2.9	-1.7	-1.4
Average weekly beer plus cider intake	2.1	3.0	3.2	1.7	1.8
Blood Platelet Count	2.0	23.1	33.3	5.8	3.6
Respiratory disease	2.0	4.5	6.2	-2.5	-1.7
Alzheimer’s Disease (in father)	1.9	2.0	2.9	1.7	1.1
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	3.2	1.8	1.7
Overall health rating	1.9	4.1	4.4	-2.1	-2.0
Length of working week for main job	1.8	2.0	2.2	-1.5	-1.3
Health satisfaction	1.8	2.3	2.6	-1.4	-1.6
Crohns Disease (2012)	1.7	2.8	4.5	2.1	1.0
Smoking Status	1.7	4.1	4.4	2.1	2.0
Number of treatments/medications taken	1.7	3.0	4.8	-2.2	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	4.1	2.0	1.9
Wears glasses or contact lenses	1.7	2.0	2.4	-1.2	-1.6
Neck or shoulder pain in last month	1.6	2.3	2.4	-1.5	-1.6
Medication: Aspirin	1.6	2.1	2.3	1.4	1.5
Medication: Lisinopril	1.6	2.1	3.1	-1.8	-1.1
HbA1C	1.5	1.6	2.3	-1.5	-1.0
Blood Red Count	1.5	14.2	18.7	4.3	3.1
Had other major operations	1.5	1.9	1.9	-1.3	-1.4
Medication: Ramipril	1.5	1.9	2.3	-1.5	-1.2
Age at first live birth	1.5	2.7	3.7	1.3	1.9
Breast cancer (self-reported)	1.5	1.7	3.0	-1.7	-0.7
Medication: Aspirin	1.5	2.0	2.5	1.2	1.6
Number of operations (self-reported)	1.5	2.3	2.7	-1.7	-1.3
Age started oral contraceptive pill	1.5	1.8	2.1	-1.2	-1.4
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	1.9	-1.4	-1.3
Diabetes (mother)	1.4	1.8	2.2	-1.2	-1.5
Illnesses of siblings	1.4	1.9	2.4	1.5	1.2
Wheeze or whistling in the chest in last year	1.4	2.5	3.1	-1.8	-1.4
Type 2 Diabetes (T2D) (2012)	1.3	1.6	2.6	0.7	1.6
Frequency of depressed mood in last 2 weeks	1.3	1.8	1.9	1.3	1.4
Medication: Cholesterol lowering	1.3	2.1	2.5	-1.6	-1.3
Birth weight of first child	1.3	2.4	3.2	-1.8	-1.2
Qualifications: College or University degree	1.3	4.2	4.5	2.1	2.0
Emphysema/chronic bronchitis	1.3	1.5	1.8	-1.3	-1.1
Long-standing illness, disability or infirmity	1.3	2.0	2.3	-1.3	-1.5
Guilty feelings	1.3	2.0	2.5	-1.2	-1.6
Financial situation satisfaction	1.3	1.7	2.4	-0.9	-1.6
Neuroticism	1.2	2.9	3.7	1.9	1.4
Chronotype (morning person)	1.2	2.8	3.4	-1.5	-1.8
Hair/balding pattern: Pattern 2	1.2	1.5	2.1	0.9	1.5
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.0	1.2	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	4.1	2.0	1.9
Asthma (self-reported)	1.2	2.5	4.1	-2.0	-0.9
Pain experienced in last month	1.2	2.1	3.0	1.7	1.1
Heart attack	1.1	1.4	1.7	1.1	1.3
High blood pressure (siblings)	1.1	1.6	2.2	-1.5	-1.0
Neuroticism (Nagel 2018)	1.0	2.5	3.2	1.8	1.3
Falls in the last year	1.0	1.4	2.4	-1.5	-0.7
Mouth/teeth dental problems: Dentures	1.0	1.7	1.8	-1.3	-1.3
Asthma	1.0	2.1	3.6	-1.9	-0.7
Depression (self-reported)	1.0	1.2	1.3	-1.1	-1.1
Breastfed as a baby	1.0	1.2	2.0	-1.4	-0.7
Eye problems/disorders: None of the above	1.0	1.1	1.7	-0.8	-1.3
Commuting to job workplace: Walk	1.0	1.1	1.6	0.8	1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.8	1.7	0.7
Mineral and other dietary supplements	1.0	1.3	1.8	-1.4	-0.9
Lupus	0.9	1.4	2.8	0.3	1.7
Ulcerative Colitis	0.9	1.3	2.6	-0.1	-1.6
Lung FVC	0.9	4.5	5.2	2.3	2.0
Townsend deprivation index at recruitment	0.9	1.2	1.5	-1.2	-0.9
Medication: Lansoprazole	0.9	1.0	1.3	-0.8	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	1.5	-1.2	-1.0
Illnesses of father: Heart disease	0.9	1.2	1.9	1.4	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.1	1.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.6	-0.6	-1.3
Osteoporosis (self-reported)	0.9	1.1	1.1	-1.0	-1.0
Crohns Disease (2017)	0.8	1.7	3.1	1.8	0.5
Height	0.8	14.9	21.9	-4.7	-2.8
Qualifications: CSEs or equivalent	0.8	1.1	1.2	-1.1	-1.0
Lung cancer (father)	0.8	0.9	1.0	-0.9	-1.0
Number of children fathered	0.8	0.9	1.7	1.3	0.4
Chest pain or discomfort	0.8	1.2	1.6	-1.3	-0.9
Miserableness	0.8	1.5	2.2	1.5	0.9
Eye problems/disorders: Glaucoma	0.8	0.9	1.4	0.6	1.2
Neuroticism (2016)	0.7	1.0	1.0	0.9	1.0
Serious illness, injury or assault to yourself	0.7	0.9	0.9	-0.9	-1.0
Worrier / anxious feelings	0.7	1.3	2.4	1.6	0.5
Pulse rate	0.7	1.2	2.3	-1.5	-0.4
Happiness	0.7	0.9	0.9	0.9	0.9
Friendships satisfaction	0.7	0.9	1.0	0.9	1.0
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.1	0.8	1.1
Waist Hip Ratio (WHR)	0.6	2.7	4.6	0.9	2.1
Sitting height	0.6	4.4	6.0	2.4	1.7
High blood pressure (mother)	0.6	0.8	1.4	-0.5	-1.2
Father’s age at death	0.6	0.8	1.0	1.0	0.7
Illnesses of mother	0.6	0.8	1.1	0.6	1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.0	1.0	0.7
Migraine (self-reported)	0.6	0.8	0.9	1.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	1.2	0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	1.2	0.2
Supplements: Vitamin C	0.6	0.7	0.8	0.7	0.9
Ever had bowel cancer screening	0.6	0.7	1.2	-0.4	-1.1
Illnesses of father: None of the above (group 1)	0.6	0.8	1.2	-1.1	-0.6
Alcohol drinker status: Previous	0.6	0.7	1.0	-1.0	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.2	1.9	-1.4	-0.6
Ovarian Cancer	0.5	0.6	0.6	0.8	0.8
Systolic Blood Pressure	0.5	2.3	2.7	-1.6	-1.4
Ever had hysterectomy (womb removed)	0.5	0.6	0.9	-1.0	-0.6
Systolic blood pressure, automated reading	0.5	1.6	1.7	-1.2	-1.3
Vitamin and mineral supplements	0.5	0.7	1.0	1.0	0.7
Supplements: Zinc	0.5	0.5	0.6	0.8	0.6
Medication: Metformin	0.5	0.8	1.5	0.1	1.2
Supplements: Glucosamine	0.5	0.7	1.3	1.2	-0.0
Prospective memory result	0.5	0.6	1.0	-0.5	-1.0
Hair/balding pattern: Pattern 4	0.5	1.2	1.4	-1.0	-1.2
Loud music exposure frequency	0.5	0.5	1.0	1.0	0.2
Glaucoma (self-reported)	0.5	0.6	0.9	0.6	1.0
Family relationship satisfaction	0.5	0.7	1.2	0.4	1.1
Average weekly red wine intake	0.5	0.8	1.1	0.7	1.0
Osteoarthritis (self-reported)	0.5	0.7	1.0	-0.6	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.6	0.8	0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	1.3	1.1	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	1.7	1.3	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.5	-1.2	-0.2
Relative age of first facial hair	0.4	0.8	1.6	0.1	1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.6	0.8	0.6
Angina	0.4	0.5	0.9	-0.3	-1.0
Relative age voice broke	0.4	0.6	1.2	-0.2	1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.5	-0.7	-0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.2	0.7	1.1
Medication: Levothyroxine sodium	0.4	0.6	1.0	-1.0	-0.5
Neuroticism score	0.4	0.9	1.6	1.3	0.5
Standing height	0.4	4.0	6.1	-2.5	-1.4
Pulse wave reflection index	0.4	0.5	0.6	-0.7	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	0.9	0.4
Angina (self-reported)	0.4	0.5	1.0	-0.3	-1.0
Mood swings	0.4	0.8	1.2	1.1	0.6
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.9	-0.4
Commuting to job workplace: Cycle	0.4	0.5	0.8	0.3	0.9
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.9	-0.5
Depression (Nagel 2018)	0.3	0.4	0.7	0.9	0.4
Schizophrenia (2018)	0.3	0.6	1.1	-1.0	-0.4
Allergy or Eczema	0.3	0.9	1.0	0.9	1.0
Current tobacco smoking	0.3	0.6	0.6	-0.7	-0.8
Age when periods started (menarche)	0.3	0.8	1.5	-1.2	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.0	-0.8
Hearing difficulty/problems with background noise	0.3	0.6	1.0	0.3	1.0
Time employed in main current job	0.3	0.3	0.6	-0.0	0.8
Noisy workplace	0.3	0.3	0.6	0.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.4	-0.6	-0.5
Comparative height size at age 10	0.3	1.9	2.0	-1.4	-1.4
Commuting to job workplace: Public transport	0.3	0.4	0.5	-0.5	0.7
Ever depressed for a whole week	0.3	0.4	0.7	0.8	0.3
Heart disease (siblings)	0.3	0.3	0.4	-0.5	-0.7
Depressed Affect (Nagel 2018)	0.2	0.5	0.6	0.8	0.6
Ulcerative Colitis (UC)	0.2	0.3	0.3	0.6	-0.6
LDL Cholesterol	0.2	0.4	0.6	0.7	0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.2	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.3	0.6	-0.4
Medication: Atenolol	0.2	0.3	0.5	0.4	0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.6	0.3
Allergy	0.2	0.4	0.7	-0.1	-0.9
Diabetes (self-reported)	0.2	0.3	0.4	-0.4	0.6
Alcohol intake versus 10 years previously	0.2	0.2	0.5	-0.7	-0.1
Number of live births	0.2	0.3	0.5	0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.0	1.0	0.7
Peak expiratory flow (PEF)	0.2	0.6	0.6	-0.7	-0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.3	0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.6	-0.1
Birth weight	0.2	0.5	0.7	-0.6	-0.8
Worry too long after embarrassment	0.2	0.3	0.6	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	0.3
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	-0.4
Medication: Ibuprofen	0.2	0.2	0.4	-0.2	0.7
Heart disease (mother)	0.2	0.3	0.5	0.7	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.2	0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.4	-0.6	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.5	0.3
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.4	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.0	0.7
Medication: Gliclazide	0.2	0.2	0.3	-0.5	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	0.3	0.6
Medication: Paracetamol	0.2	0.3	0.7	0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	0.4	0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.6	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	0.6	0.4
Mean Putamen Volume	0.1	0.1	0.2	-0.0	0.4
HDL Cholesterol	0.1	0.1	0.2	-0.2	-0.4
Schizophrenia (2014)	0.1	0.3	0.5	-0.7	-0.3
Hypothyroidism (self reported)	0.1	0.1	0.2	-0.2	0.4
Average weekly spirits intake	0.1	0.2	0.3	0.1	0.6
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.5	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.1	0.4	0.3
Diabetes (father)	0.1	0.1	0.2	-0.5	0.0
Severe depression (siblings)	0.1	0.1	0.2	-0.4	-0.1
Pack years adult smoking proportion	0.1	0.1	0.2	-0.4	-0.3
Fed-up feelings	0.1	0.1	0.2	-0.4	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.2	0.5	-0.3
Had menopause	0.1	0.2	0.3	-0.5	-0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	-0.4	-0.4
Qualifications: None of the above	0.1	0.1	0.3	-0.0	0.5
Medication: Simvastatin	0.1	0.1	0.2	-0.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.6	-0.1
Medication: Paracetamol	0.1	0.1	0.2	-0.3	0.4
Gout (self-reported)	0.1	0.2	0.2	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.1	-0.3	0.3
Medication: Amlodipine	0.1	0.2	0.2	0.3	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.5	0.6	0.7
Number of full brothers	0.1	0.1	0.1	0.1	0.3
Medication for pain relief, constipation, heartburn	0.1	0.3	0.5	-0.1	-0.7
Medication: Allopurinol	0.1	0.2	0.4	0.1	-0.6
Medication: Omeprazole	0.1	0.1	0.2	0.4	0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.1	0.4
Had major operations	0.1	0.1	0.2	-0.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.4	0.3
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	-0.3
Back pain experienced in last month	0.1	0.1	0.1	-0.3	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.4	-0.3
Hearing aid user	0.1	0.1	0.2	-0.4	-0.3
Mother’s age at death	0.1	0.2	0.3	-0.3	-0.5
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.5	0.2
Alcohol drinker status: Never	0.1	0.2	0.2	-0.5	-0.4
Myopia	0.1	0.1	0.2	-0.1	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.1	-0.2
Reaction Time	0.0	0.0	0.0	0.0	-0.1
Breast Cancer	0.0	0.0	0.0	0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.0	-0.2
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.2	0.3	0.5	0.4
Tanning	0.0	0.2	0.2	-0.4	0.4
Sensitivity / hurt feelings	0.0	0.1	0.1	0.3	-0.2
Taking other prescription medications	0.0	0.1	0.1	-0.3	0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.2
Alcohol usually taken with meals	0.0	0.0	0.1	0.1	-0.2
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.1	-0.1
Mouth/teeth dental problems	0.0	0.0	0.0	0.0	-0.1
Fluid intelligence score	0.0	0.1	0.1	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.2	-0.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.0	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.1	-0.0	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.3	-0.1
Headache pain in last month	0.0	0.1	0.1	-0.4	0.0
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.1	0.0
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	0.1
Mean time to correctly identify matches	0.0	0.0	0.1	0.1	-0.3
Number of full sisters	0.0	0.0	0.0	0.1	-0.1
Leg pain on walking	0.0	0.1	0.1	0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	0.1	0.2
Loneliness, isolation	0.0	0.0	0.1	0.3	-0.1
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.1	0.0
Smoking status: Current	0.0	0.0	0.0	-0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.1	0.1
Risk taking	0.0	0.0	0.0	0.0	0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	0.3	0.0
Pack years of smoking	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

ZNF689

Models

Trait associations