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chr11:46,010,847-48,783,497

Best TWAS P=4.15e-25 · Best GWAS P=1.81e-20 conditioned to 5.67e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Cells EBV-transformed lymphocytes	ACP2	0.17	0.03	lasso	6	0.03	4.2e-02	-7.47	10.4	4.2e-25	-0.47	0.05	0.86	TRUE
41	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	8.21	-9.5	1.4e-21	0.40	0.13	0.82	FALSE
21	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	-8.38	9.1	6.9e-20	-0.43	0.02	0.98	FALSE
28	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	-7.38	8.8	1.3e-18	-0.39	0.06	0.88	FALSE
16	GTEx	Breast Mammary Tissue (Female)	ACP2	0.03	0.00	lasso	1	0.02	1.0e-01	-8.72	8.7	3.7e-18	-0.60	0.02	0.13	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AGBL2	0.03	0.02	enet	7	0.03	7.9e-05	-8.38	-8.6	5.6e-18	0.70	0.30	0.67	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	-7.77	8.6	1.2e-17	-0.39	0.16	0.80	FALSE
26	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	-8.95	8.3	9.1e-17	-0.35	0.04	0.96	FALSE
7	GTEx	Adipose Visceral Omentum	ACP2	0.08	0.05	lasso	5	0.05	1.4e-03	-8.03	8.3	1.3e-16	-0.36	0.14	0.67	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	SLC39A13	0.07	0.11	lasso	2	0.10	5.2e-06	-8.24	-8.3	1.4e-16	0.55	0.21	0.46	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PTPRJ	0.06	0.04	lasso	4	0.05	7.6e-07	-8.80	-8.2	2.2e-16	0.68	0.21	0.79	FALSE
44	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	-6.68	8.1	6.1e-16	-0.37	0.07	0.78	FALSE
58	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACP2	0.02	0.03	lasso	1	0.02	1.5e-03	-8.03	8.0	9.4e-16	-0.35	0.04	0.57	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	-6.87	-8.0	1.2e-15	0.36	0.30	0.70	FALSE
14	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	-7.85	-8.0	1.4e-15	0.34	0.14	0.15	FALSE
39	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	-7.77	8.0	1.9e-15	-0.34	0.17	0.73	FALSE
40	GTEx	Thyroid	ACP2	0.19	0.14	lasso	4	0.12	3.0e-09	-8.03	7.9	3.4e-15	-0.34	0.76	0.24	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	DDB2	0.06	0.04	enet	17	0.03	1.3e-03	-8.99	-7.8	7.6e-15	0.39	0.00	0.99	FALSE
25	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-8.95	7.7	1.2e-14	-0.43	0.02	0.96	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	7.52	-7.5	5.3e-14	0.35	0.44	0.04	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDB2	0.02	0.03	lasso	1	0.02	1.0e-03	-7.44	-7.4	1.0e-13	0.29	0.12	0.27	FALSE
43	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	-8.38	7.4	1.2e-13	-0.40	0.02	0.97	FALSE
29	GTEx	Muscle Skeletal	FNBP4	0.05	0.03	lasso	5	0.04	5.0e-05	-8.24	-7.2	5.2e-13	0.39	0.42	0.38	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	NR1H3	0.06	0.01	blup	302	0.04	1.5e-05	-8.38	-7.2	5.3e-13	0.39	0.18	0.80	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-8.38	-7.1	1.3e-12	0.57	0.00	0.94	FALSE
17	GTEx	Breast Mammary Tissue (Female)	PSMC3	0.02	0.01	lasso	1	0.04	2.5e-02	-7.08	7.1	1.4e-12	-0.61	0.03	0.08	FALSE
12	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	-6.87	7.0	2.7e-12	-0.31	0.08	0.14	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	4.32	-7.0	3.5e-12	0.33	0.26	0.08	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	7.52	-6.8	1.4e-11	0.20	0.08	0.12	FALSE
10	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-3.40	6.8	1.5e-11	-0.19	0.12	0.67	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	-4.60	-6.7	2.4e-11	0.31	0.49	0.47	FALSE
37	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	-7.80	6.5	1.1e-10	-0.30	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	C11orf49	0.17	0.01	enet	21	0.05	9.5e-05	-8.78	-6.3	2.3e-10	0.33	0.08	0.81	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	CKAP5	0.11	0.04	lasso	3	0.03	2.1e-02	-4.76	-6.3	3.2e-10	0.26	0.23	0.24	FALSE
32	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	-4.76	6.2	5.8e-10	-0.26	0.87	0.06	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	-0.96	6.2	7.7e-10	-0.40	0.13	0.70	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	DDB2	0.07	0.02	enet	13	0.04	3.5e-03	-7.38	-6.1	9.9e-10	0.25	0.14	0.08	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARHGAP1	0.16	0.04	enet	18	0.04	2.3e-05	3.44	6.0	1.6e-09	-0.22	0.67	0.02	FALSE
9	GTEx	Artery Tibial	MADD	0.09	0.00	enet	13	0.02	1.1e-02	8.11	-6.0	2.0e-09	0.26	0.46	0.03	FALSE
11	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	-7.82	6.0	2.2e-09	-0.24	0.12	0.71	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	-8.78	5.9	3.4e-09	-0.27	0.01	0.81	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACP2	0.02	0.01	blup	44	0.02	2.7e-04	-8.03	5.8	7.0e-09	-0.26	0.03	0.34	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	PTPMT1	0.03	0.02	blup	270	0.02	3.8e-04	-8.24	-5.7	1.1e-08	0.48	0.09	0.86	FALSE
15	GTEx	Brain Putamen basal ganglia	CKAP5	0.25	0.07	lasso	3	0.14	4.4e-04	-9.04	-5.7	1.2e-08	0.29	0.02	0.68	FALSE
22	GTEx	Esophagus Mucosa	C11orf49	0.19	0.05	enet	21	0.12	3.2e-08	-6.40	-5.7	1.2e-08	0.28	0.71	0.12	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf49	0.05	0.00	blup	90	0.02	3.0e-04	-7.22	-5.7	1.2e-08	0.26	0.00	0.98	FALSE
24	GTEx	Heart Atrial Appendage	ACP2	0.10	0.12	enet	7	0.10	2.7e-05	-7.31	5.6	1.9e-08	-0.26	0.18	0.48	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	-8.38	5.6	2.2e-08	-0.26	0.01	0.80	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACP2	0.09	0.04	enet	12	0.06	5.0e-07	-7.82	5.5	2.9e-08	-0.31	0.39	0.60	FALSE
42	METSIM	Adipose	RAPSN	0.11	0.01	enet	21	0.06	7.9e-09	-5.46	-5.5	3.0e-08	0.36	0.98	0.01	FALSE
65	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF408	0.27	0.01	blup	27	0.09	1.5e-03	-6.30	5.5	3.0e-08	-0.25	0.00	0.83	FALSE
5	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	-7.82	5.5	3.1e-08	-0.30	0.21	0.42	FALSE
27	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	-5.62	5.5	3.7e-08	-0.24	0.08	0.65	FALSE
38	GTEx	Spleen	ACP2	0.19	-0.01	lasso	5	0.04	4.1e-02	-6.68	5.5	4.0e-08	-0.29	0.07	0.42	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	ZNF408	0.04	0.02	blup	243	0.03	5.0e-05	-4.32	5.5	4.4e-08	-0.22	0.12	0.87	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	-5.24	-5.4	7.9e-08	0.24	0.96	0.02	FALSE
45	NTR	Blood	PTPRJ	0.04	0.01	blup	285	0.02	8.5e-08	-4.83	-5.4	7.9e-08	0.35	0.78	0.21	FALSE
23	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	3.47	-5.3	9.5e-08	0.28	0.73	0.02	FALSE
6	GTEx	Adipose Subcutaneous	PTPRJ	0.05	0.05	lasso	2	0.04	3.9e-04	-4.71	-5.3	9.6e-08	0.80	0.17	0.48	FALSE
33	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	7.46	-5.3	1.0e-07	0.12	0.65	0.04	FALSE
31	GTEx	Nerve Tibial	CELF1	0.08	0.02	enet	15	0.06	4.3e-05	4.86	-5.3	1.1e-07	0.34	0.21	0.06	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	CELF1	0.03	0.01	bslmm	289	0.01	2.9e-02	-3.53	-5.2	1.7e-07	0.55	0.18	0.04	FALSE
53	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	-7.44	5.2	2.0e-07	-0.18	1.00	0.00	FALSE
36	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	-4.73	-5.2	2.5e-07	0.24	1.00	0.00	FALSE
8	GTEx	Adipose Visceral Omentum	ARHGAP1	0.12	0.02	enet	15	0.04	3.8e-03	-1.80	5.1	3.0e-07	-0.14	0.04	0.65	FALSE