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chr10:101,975,269-105,647,095

Best TWAS P=2.35e-19 · Best GWAS P=2.75e-14 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	6.1	6.3	3.9e-10	0.05	0.21	0.42	TRUE
2	GTEx	Adipose Visceral Omentum	SFXN2	0.25	0.16	enet	20	0.18	8.8e-10	2.4	-5.3	1.2e-07	-0.04	0.93	0.03	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-179B2.2	0.13	0.02	lasso	3	0.03	6.5e-03	5.8	5.5	4.9e-08	0.71	0.29	0.43	FALSE
4	GTEx	Artery Aorta	TMEM180	0.25	0.23	enet	37	0.25	7.4e-14	3.8	7.1	1.5e-12	0.04	1.00	0.00	TRUE
5	GTEx	Artery Aorta	ARL3	0.19	0.07	lasso	6	0.06	4.8e-04	6.1	-6.5	6.4e-11	-0.07	0.18	0.70	FALSE
6	GTEx	Artery Aorta	RP11-179B2.2	0.16	0.11	lasso	2	0.09	7.6e-06	5.9	5.5	3.1e-08	0.73	0.68	0.07	FALSE
7	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	5.7	-5.6	2.7e-08	-0.02	0.34	0.09	FALSE
8	GTEx	Artery Tibial	TMEM180	0.07	0.05	enet	14	0.03	3.8e-03	3.7	5.4	8.6e-08	0.06	0.93	0.02	FALSE
9	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	5.7	5.5	4.3e-08	0.03	0.85	0.02	FALSE
10	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	5.2	5.5	4.0e-08	0.00	0.37	0.14	FALSE
11	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-4.8	-9.0	2.4e-19	-0.10	0.07	0.38	TRUE
12	GTEx	Brain Cerebellum	RP11-179B2.2	0.37	0.21	lasso	4	0.20	1.4e-06	5.9	6.5	5.9e-11	0.70	0.40	0.14	TRUE
13	GTEx	Brain Frontal Cortex BA9	RP11-179B2.2	0.22	0.15	lasso	2	0.11	7.2e-04	5.9	5.4	7.6e-08	0.70	0.15	0.30	FALSE
14	GTEx	Breast Mammary Tissue	SFXN2	0.11	0.00	enet	12	0.03	1.3e-02	3.7	-5.9	3.7e-09	-0.04	0.19	0.05	FALSE
15	GTEx	Breast Mammary Tissue	RP11-179B2.2	0.11	0.09	lasso	2	0.07	1.8e-04	5.8	5.2	2.5e-07	0.70	0.58	0.18	FALSE
16	GTEx	Breast Mammary Tissue (Male)	TMEM180	0.26	0.15	lasso	17	0.17	1.0e-04	3.7	5.3	1.4e-07	0.05	0.28	0.17	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	7.1	6.3	2.9e-10	0.03	0.04	0.47	FALSE
18	GTEx	Cells Transformed fibroblasts	GBF1	0.07	0.00	enet	2	0.00	1.4e-01	6.1	5.8	4.9e-09	0.07	0.05	0.45	FALSE
19	GTEx	Cells Transformed fibroblasts	SUFU	0.07	0.04	lasso	3	0.04	3.5e-04	7.1	7.5	7.8e-14	0.06	0.07	0.84	FALSE
20	GTEx	Colon Sigmoid	ARL3	0.13	0.10	lasso	6	0.05	5.5e-03	6.1	-6.2	4.5e-10	-0.06	0.14	0.43	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	5.4	5.9	2.9e-09	0.02	0.14	0.43	FALSE
22	GTEx	Esophagus Muscularis	RP11-179B2.2	0.15	0.16	lasso	3	0.16	8.1e-10	6.0	6.0	2.3e-09	0.71	0.99	0.01	FALSE
23	GTEx	Heart Left Ventricle	RP11-179B2.2	0.15	0.18	enet	2	0.14	4.8e-08	5.9	5.9	3.4e-09	0.74	0.89	0.10	FALSE
24	GTEx	Lung	TMEM180	0.12	0.11	lasso	4	0.13	5.1e-10	3.8	5.3	1.1e-07	0.04	0.98	0.02	FALSE
25	GTEx	Lung	RP11-179B2.2	0.18	0.12	lasso	3	0.12	1.7e-09	5.9	5.4	5.4e-08	0.71	0.97	0.03	FALSE
26	GTEx	Muscle Skeletal	TMEM180	0.05	0.01	lasso	6	0.01	8.3e-02	4.4	5.5	3.5e-08	0.06	0.06	0.54	TRUE
27	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	5.0	5.2	2.0e-07	0.01	0.56	0.13	FALSE
28	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	7.1	5.2	1.7e-07	0.09	0.04	0.92	FALSE
29	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	7.2	-7.3	2.6e-13	-0.05	0.02	0.97	TRUE
30	GTEx	Thyroid	C10orf95	0.10	0.02	enet	28	0.02	6.6e-03	3.7	6.8	8.5e-12	0.04	0.20	0.10	TRUE
31	GTEx	Thyroid	TMEM180	0.31	0.38	enet	20	0.42	8.1e-35	3.7	5.3	1.4e-07	0.05	1.00	0.00	TRUE
32	GTEx	Thyroid	SFXN2	0.28	0.06	enet	32	0.15	1.1e-11	-2.7	-5.3	1.4e-07	0.00	1.00	0.00	FALSE
33	GTEx	Thyroid	RP11-18I14.10	0.14	0.03	enet	24	0.07	3.5e-06	2.5	5.5	4.7e-08	0.07	0.61	0.02	FALSE
34	METSIM	Adipose	SFXN3	0.12	0.00	blup	415	0.04	1.6e-06	3.0	5.9	3.4e-09	0.26	0.16	0.03	TRUE
35	ROSMAP	Brain Pre-frontal Cortex	ARL3	0.24	0.14	bslmm	368	0.16	3.9e-20	6.1	-7.8	9.1e-15	-0.05	0.62	0.38	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	7.2	7.2	5.2e-13	0.06	0.02	0.98	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	TRIM8	0.09	0.03	enet	25	0.06	3.7e-08	-4.9	-5.3	9.3e-08	-0.06	1.00	0.00	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	5.2	5.8	5.1e-09	0.02	1.00	0.00	FALSE
39	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	7.3	6.3	3.6e-10	0.05	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	5.8	-7.2	7.6e-13	-0.02	0.26	0.72	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ARL3	0.09	0.02	blup	57	0.05	1.8e-03	6.1	-6.7	1.8e-11	-0.07	0.01	0.62	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARL3	0.03	0.02	lasso	3	0.02	1.1e-03	6.7	-6.5	1.2e-10	-0.06	0.01	0.91	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	5.8	-5.8	6.8e-09	-0.01	0.74	0.10	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM180	0.06	0.03	lasso	5	0.03	3.7e-04	6.2	6.3	3.6e-10	0.06	0.01	0.98	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACTR1A	0.04	0.01	blup	51	0.02	7.1e-04	3.6	6.9	5.2e-12	0.10	0.04	0.18	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARL3	0.04	0.02	blup	57	0.03	9.2e-04	6.1	-5.9	3.2e-09	-0.06	0.04	0.74	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	ARL3	0.06	0.07	lasso	4	0.06	3.5e-06	6.1	-5.6	1.8e-08	-0.05	0.03	0.97	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	5.8	-5.3	1.2e-07	-0.01	0.99	0.01	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	5.4	-6.5	6.8e-11	-0.02	0.28	0.53	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	6.0	-6.0	2.4e-09	-0.03	0.08	0.16	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM180	0.14	0.08	lasso	3	0.10	4.6e-10	4.4	5.7	1.6e-08	0.06	0.08	0.92	FALSE