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chr4:85,698,680-89,590,831

Best TWAS P=1.13e-27 · Best GWAS P=2.99e-33 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	METSIM	Adipose	HSD17B13	0.20	0.10	bslmm	416	0.12	7.3e-18	6.754	-10.9	1.1e-27	0.32	1.00	0.00	TRUE
6	GTEx	Artery Aorta	RP13-514E23.2	0.26	0.09	lasso	6	0.10	2.2e-06	-9.088	-9.9	4.2e-23	0.03	0.00	1.00	TRUE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IBSP	0.08	0.00	blup	77	0.00	1.6e-01	-4.187	8.9	4.5e-19	-0.72	0.03	0.44	TRUE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	IBSP	0.09	0.02	enet	15	0.07	9.4e-05	-0.604	8.5	1.4e-17	-0.65	0.02	0.70	TRUE
12	GTEx	Colon Sigmoid	MAPK10	0.25	0.11	lasso	8	0.07	1.6e-03	7.642	-7.8	5.5e-15	0.09	0.39	0.10	TRUE
10	GTEx	Brain Cerebellar Hemisphere	NUDT9	0.28	0.00	enet	29	0.19	1.1e-05	-0.141	7.8	7.9e-15	-0.35	0.07	0.11	TRUE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	IBSP	0.05	0.05	lasso	6	0.07	1.2e-13	-10.378	6.3	3.2e-10	-0.81	0.01	0.99	TRUE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPP1	0.04	0.00	enet	11	0.01	3.3e-03	6.984	6.2	6.7e-10	-0.16	0.00	0.97	TRUE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B11	0.35	0.01	enet	11	0.07	8.2e-09	0.968	-5.8	7.0e-09	0.02	0.03	0.40	TRUE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MEPE	0.09	0.03	enet	19	0.04	1.0e-05	-6.689	-5.7	1.0e-08	0.25	0.07	0.12	TRUE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD17B11	0.06	0.02	blup	51	0.05	2.2e-04	-5.716	-5.6	2.1e-08	-0.04	0.01	0.80	TRUE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	PTPN13	0.06	0.05	lasso	4	0.04	3.3e-05	-4.665	-5.3	1.1e-07	0.10	0.54	0.13	TRUE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	DMP1	0.05	0.04	enet	4	0.04	2.1e-05	-7.212	10.2	2.0e-24	-0.78	0.06	0.89	FALSE
5	GTEx	Artery Aorta	ARHGAP24	0.24	0.13	enet	8	0.14	2.2e-08	-8.437	-9.8	7.1e-23	0.02	0.01	0.99	FALSE
9	GTEx	Artery Tibial	RP13-514E23.2	0.22	0.16	enet	10	0.18	1.2e-13	-9.088	-9.3	9.1e-21	0.02	0.00	1.00	FALSE
7	GTEx	Artery Tibial	ARHGAP24	0.26	0.19	enet	14	0.21	2.7e-16	-9.088	-9.1	1.4e-19	0.01	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	IBSP	0.06	0.01	blup	78	0.03	7.7e-05	-10.378	8.6	6.8e-18	-0.77	0.01	0.97	FALSE
15	GTEx	Nerve Tibial	RP13-514E23.2	0.17	0.00	lasso	6	0.00	1.9e-01	-8.553	-8.1	3.8e-16	0.04	0.05	0.30	FALSE
16	GTEx	Thyroid	PTPN13	0.41	0.31	lasso	6	0.30	3.2e-23	7.661	7.8	8.7e-15	-0.05	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	RP13-514E23.2	0.09	0.03	enet	11	0.04	2.0e-04	-8.437	-7.4	1.3e-13	0.04	0.06	0.83	FALSE
4	GTEx	Artery Aorta	MAPK10	0.15	0.17	enet	16	0.17	1.4e-09	7.589	-7.0	2.2e-12	0.05	0.99	0.00	FALSE
20	NTR	Blood	AFF1	0.02	0.00	bslmm	429	0.01	3.7e-03	-1.111	6.9	4.8e-12	-0.17	0.11	0.08	FALSE
13	GTEx	Esophagus Muscularis	HSD17B13	0.12	0.04	lasso	5	0.02	1.9e-02	6.754	-6.9	6.6e-12	0.01	0.09	0.04	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSD17B11	0.05	0.02	enet	9	0.04	2.6e-05	2.765	-6.6	4.8e-11	0.00	0.01	0.93	FALSE
14	GTEx	Nerve Tibial	SPP1	0.15	0.08	lasso	3	0.08	2.4e-06	6.028	6.1	8.9e-10	-0.05	0.95	0.00	FALSE
32	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPP1	0.14	0.03	blup	64	0.07	1.0e-03	5.982	6.1	1.1e-09	-0.09	0.03	0.28	FALSE
11	GTEx	Breast Mammary Tissue	RP11-529H2.2	0.22	0.07	enet	9	0.06	6.3e-04	-4.947	-5.7	9.6e-09	-0.06	0.35	0.10	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC100506746	0.05	0.01	bslmm	325	0.02	4.6e-04	0.083	-5.7	1.1e-08	0.14	0.09	0.03	FALSE
3	GTEx	Adipose Visceral Omentum	HSD17B13	0.17	0.02	enet	18	0.05	2.1e-03	-2.675	-5.5	3.7e-08	0.02	0.90	0.00	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B13	0.04	0.01	blup	43	0.02	3.2e-03	-4.029	5.4	5.4e-08	0.07	0.03	0.27	FALSE
17	GTEx	Thyroid	HSD17B11	0.15	0.04	enet	16	0.05	1.6e-04	-4.947	-5.4	7.0e-08	-0.18	0.30	0.03	FALSE
18	GTEx	Thyroid	RP11-529H2.2	0.10	0.06	lasso	5	0.04	4.4e-04	-4.947	-5.2	1.6e-07	-0.10	0.71	0.04	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	C4orf36	0.06	0.01	blup	36	0.02	7.3e-03	4.679	5.2	2.2e-07	-0.15	0.00	0.29	FALSE
8	GTEx	Artery Tibial	RP11-397E7.4	0.07	0.03	lasso	7	0.03	4.2e-03	-4.314	5.2	2.7e-07	-0.18	0.45	0.05	FALSE