TWAS hub - TMEM88

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0913	0.0278	9.9e-05	0.017	0.026	0.023	0.028	0.019	1.1e-03	8.1e-05	1.8e-04	4.6e-05	5.9e-04
2	YFS	Blood	0.1050	0.0222	1.7e-12	0.049	0.054	0.065	0.063	0.063	8.9e-16	3.4e-17	2.2e-20	7.0e-20	1.1e-19
3	TCGA	Prostate Adenocarcinoma	0.0616	0.0310	5.5e-03	-0.001	0.006	0.006	NA	0.002	4.0e-01	7.0e-02	6.5e-02	NA	1.9e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel T-Score	4.4	35.2	48.9	-4.1	6.3	-7.0
Deep venous thrombosis (DVT) (self-reported)	4.2	5.4	11.0	0.8	-2.1	3.3
Medication: Blood pressure	3.9	7.5	9.5	3.1	-1.9	3.0
Blood clot in the leg (DVT)	3.7	4.8	8.6	0.5	-2.4	2.9
Average weekly red wine intake	3.5	5.1	9.1	-2.3	-0.9	-3.0
Family relationship satisfaction	3.4	4.2	4.9	-2.2	-2.1	-1.7
Blood Red Count	3.1	29.7	48.6	6.1	-1.8	7.0
Hearing difficulty/problems with background noise	3.1	5.0	10.0	-3.2	-0.1	-2.2
Medication: Bendroflumethiazide	3.1	4.6	10.5	3.2	0.4	1.8
Ever smoked	3.0	5.3	14.5	-0.9	-0.7	-3.8
Number of live births	2.7	3.8	7.2	-0.1	-2.7	2.1
Unable to work because of sickness or disability	2.7	3.4	6.6	-1.9	-2.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.9	10.8	-1.4	3.3	-2.2
Stomach or abdominal pain in last month	2.6	3.3	8.5	-1.1	-2.9	0.0
Friendships satisfaction	2.6	3.2	6.5	-1.6	-0.8	-2.5
Wears glasses or contact lenses	2.6	3.0	6.8	-0.0	1.4	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	13.0	-1.2	3.6	-1.6
High blood pressure	2.4	6.8	12.9	1.7	-3.6	2.1
High blood pressure (mother)	2.4	3.4	6.7	2.6	-0.6	1.8
Medication: Amlodipine	2.4	3.4	5.3	0.5	-2.1	2.3
Blood Platelet Count	2.3	27.0	40.3	5.8	2.7	6.3
Hearing difficulty/problems: Yes	2.3	3.6	8.0	-2.8	0.7	-1.5
Hypertension (Self-reported)	2.3	6.3	13.3	1.3	-3.6	2.0
Had other major operations	2.2	2.6	4.2	-1.6	-2.1	-1.0
Impedance of arm (right)	2.2	10.1	20.6	-2.8	-1.4	-4.5
Impedance of arm (left)	2.2	10.0	20.2	-2.7	-1.5	-4.5
Pulse wave peak to peak time	2.2	2.6	4.8	-2.2	-1.5	-0.9
Medication: Lisinopril	2.2	2.9	7.1	1.0	-2.7	0.7
Medication: Levothyroxine sodium	2.1	3.6	7.8	-0.7	-1.6	2.8
Worrier / anxious feelings	2.1	3.9	11.6	-0.1	0.2	-3.4
Pain type(s) experienced in last month: Hip pain	2.1	2.7	5.0	-1.7	-0.3	-2.2
Schizophrenia (2018)	2.0	4.1	7.0	-2.3	0.2	-2.6
Schizophrenia vs Biploar Disorder	2.0	2.6	7.5	-2.7	-0.6	0.0
Breast Cancer	2.0	4.9	6.1	-2.5	1.8	-2.3
Past tobacco smoking	2.0	3.7	5.8	1.6	1.7	2.4
Pulse wave reflection index	2.0	2.5	4.4	1.8	0.2	2.1
Neck or shoulder pain in last month	2.0	2.9	4.3	-2.0	-2.1	0.7
Alcohol intake frequency.	2.0	4.7	7.8	1.0	2.3	2.8
Medication for cholesterol	2.0	3.1	4.2	-2.0	1.5	-1.7
Number of self-reported non-cancer illnesses	2.0	3.4	5.3	1.5	-2.3	1.6
Systolic Blood Pressure	1.9	9.8	12.9	2.7	-3.0	3.6
Cardiovascular Disease	1.9	6.3	6.7	2.5	-2.5	2.6
Current tobacco smoking	1.9	3.0	6.7	-1.1	-1.1	-2.6
Mouth/teeth dental problems	1.9	2.9	7.3	-1.1	-2.7	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	3.8	-0.2	-2.0	-1.8
Townsend deprivation index at recruitment	1.8	2.5	6.1	0.4	-1.2	2.5
Hair/balding pattern: Pattern 3	1.8	2.7	4.2	1.1	-1.6	2.1
Overall health rating	1.8	3.9	5.5	-1.3	-2.3	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.0	-2.0	-1.2	0.4
Noisy workplace	1.7	2.1	4.2	2.0	1.3	0.5
Pulse wave Arterial Stiffness index	1.7	2.0	3.6	1.9	1.5	0.4
Medication: Blood pressure	1.7	3.0	8.3	0.0	-2.9	0.8
Smoking status: Current	1.7	2.7	5.5	-1.1	-1.2	-2.3
Vascular/heart problems diagnosed by doctor	1.7	4.6	9.9	-1.6	3.1	-1.1
Smoking Status	1.6	3.9	7.3	-1.7	-1.2	-2.7
Chronotype (morning person)	1.6	3.7	6.0	2.0	1.1	2.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.0	-1.1	2.0	-0.2
Medication: Atenolol	1.6	2.0	2.7	1.6	-0.8	1.6
Hair/balding pattern: Pattern 2	1.6	2.1	4.6	-2.1	0.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	5.0	0.6	0.4	2.2
Number of full sisters	1.6	2.0	3.0	0.9	-1.5	1.7
Illnesses of father: High blood pressure	1.6	2.0	3.2	1.5	-1.8	0.7
Diastolic blood pressure, automated reading	1.6	5.0	8.8	1.2	-2.1	3.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.0	-0.2	-1.6	1.7
Breastfed as a baby	1.5	1.9	5.0	-0.3	2.2	-0.7
Loud music exposure frequency	1.5	1.6	2.6	-1.6	0.6	-1.4
High blood pressure (siblings)	1.5	2.2	3.5	1.9	1.5	-0.9
Loneliness, isolation	1.5	2.1	3.3	-1.8	-0.9	-1.5
Commuting to job workplace: Walk	1.5	1.6	3.5	0.8	0.7	-1.9
Crohns Disease (2017)	1.4	3.1	6.0	-1.9	-2.4	0.2
Schizophrenia (2014)	1.4	3.0	5.3	-1.7	-0.9	-2.3
Ever had hysterectomy (womb removed)	1.4	1.6	3.8	0.1	-1.0	2.0
Diabetes (mother)	1.4	1.8	5.3	0.4	-0.0	2.3
Age when periods started (menarche)	1.4	3.3	7.6	0.4	-1.5	2.8
Qualifications: None of the above	1.4	3.0	8.3	-0.8	-2.9	0.3
Pain all over the body in last month	1.4	1.5	2.9	1.2	-1.7	0.3
Time employed in main current job	1.4	1.7	4.7	0.5	2.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.4	0.1	-2.3	-1.2
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	5.4	2.3	1.2	-0.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.3	-1.1	-1.8	-0.6
Medication: Allopurinol	1.4	1.9	4.0	0.8	-2.0	1.0
Osteoporosis (self-reported)	1.4	1.8	3.3	1.1	0.9	1.8
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.0	-0.5	1.0	-2.0
Ever depressed for a whole week	1.4	1.8	3.1	-1.8	1.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	3.7	1.1	-0.6	1.9
Bipolar Disorder (2018)	1.3	2.0	4.6	-0.0	-1.2	2.1
Worry (Nagel 2018)	1.3	2.7	8.2	-0.2	0.0	-2.9
Average weekly spirits intake	1.3	1.6	2.4	-0.8	1.3	-1.6
Angina	1.3	1.7	3.1	-1.2	-0.6	-1.8
Qualifications: A levels/AS levels or equivalent	1.3	2.8	5.5	0.5	2.4	1.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	3.7	0.2	1.9	-1.1
Number of full brothers	1.3	1.6	3.7	1.9	0.1	1.1
Number of children fathered	1.3	1.5	2.9	-0.8	1.7	-0.9
Health satisfaction	1.3	1.7	3.1	-1.3	0.4	-1.8
Mother’s age at death	1.3	1.6	3.7	0.6	1.9	-0.9
High cholesterol (Self-reported)	1.3	2.3	6.2	2.5	0.0	0.9
Medication: Paracetamol	1.3	1.9	2.6	1.6	0.8	1.6
Impedance of whole body	1.3	6.4	13.0	-1.5	-2.0	-3.6
Prostate Cancer	1.2	1.7	2.7	1.6	1.5	0.5
Hypothyroidism (self reported)	1.2	2.8	7.1	-0.6	-0.9	2.7
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.2	-1.1	-1.8	-0.8
Medication: Co-codamol	1.2	1.4	2.5	1.1	-1.6	0.7
Medication: Simvastatin	1.2	1.8	5.0	2.2	-0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.8	-1.1	-1.3	1.1
Migraine (self-reported)	1.2	1.4	1.8	1.0	1.4	-1.2
Qualifications: nursing, teaching	1.2	1.8	4.5	0.3	2.1	-0.9
Mineral and other dietary supplements	1.2	1.6	2.5	0.3	-1.4	1.6
Miserableness	1.2	2.0	5.1	0.3	-2.3	0.9
Commuting to job workplace: Cycle	1.2	1.4	3.0	1.1	0.4	1.7
Irritable Bowel Disease (IBD)	1.1	2.7	4.1	-2.0	-2.0	-0.0
Crohns Disease (2012)	1.1	1.8	3.9	-1.2	-2.0	0.0
Primary Biliary Cirrhosis	1.1	1.6	4.2	0.2	-2.0	-0.8
Lung FVC	1.1	5.4	12.0	3.5	-2.1	0.1
Pack years adult smoking proportion	1.1	1.7	4.0	-1.0	0.2	2.0
Multivitamins +/- minerals	1.1	1.4	3.4	-0.4	0.8	-1.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.6	-1.1	0.3	-1.6
Heart attack	1.1	1.5	2.2	-0.5	-1.5	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	3.5	0.7	-1.1	-1.9
Qualifications: College or University degree	1.1	3.6	6.7	-0.8	1.9	2.6
Angina (self-reported)	1.1	1.5	2.8	-1.1	-0.8	-1.7
Financial situation satisfaction	1.1	1.4	3.8	0.5	-1.9	-0.4
Number of operations (self-reported)	1.1	1.6	4.8	0.2	-0.0	-2.2
Cholesterol lowering medication	1.1	1.7	3.2	1.8	-0.5	1.3
Pack years of smoking	1.1	1.6	3.7	-0.9	0.5	1.9
Neuroticism (Nagel 2018)	1.0	2.3	4.2	-1.2	-1.2	-2.0
Triglycerides	1.0	1.7	3.4	1.3	-1.8	-0.3
BMI	1.0	5.9	17.2	-0.1	0.7	4.2
Severe depression (siblings)	1.0	1.1	2.9	1.7	0.5	0.3
Taking other prescription medications	1.0	1.5	4.4	0.2	-2.1	0.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.3	-0.1	0.4	1.8
Nervous feelings	1.0	1.9	4.0	-0.6	-1.2	-2.0
Pulse rate	1.0	1.7	3.5	1.9	1.2	-0.2
Medication: Aspirin	1.0	1.3	3.8	0.2	-1.9	0.2
Illnesses of father: None of the above (group 1)	1.0	1.2	3.5	-0.0	0.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	2.9	1.7	-1.3	1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.2	-0.5	-1.5	-1.1
Age at First Birth	0.9	1.3	2.7	-1.6	-0.3	-1.1
Body Mass Index (BMI) (2010)	0.9	1.2	2.5	1.6	-0.5	0.9
HbA1C	0.9	1.0	2.1	1.4	-0.7	-0.6
Lung FEV1/FVC ratio	0.9	4.5	8.0	1.2	2.0	2.8
Relative age voice broke	0.9	1.4	2.2	-1.1	0.9	1.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.5	-1.2	-0.2	-1.2
Number of incorrect matches in round	0.9	1.5	3.5	0.7	-1.9	-0.6
Had menopause	0.9	1.1	1.7	0.3	1.3	-1.2
Comparative body size at age 10	0.9	2.4	4.0	1.6	2.0	-0.9
Shortness of breath walking on level ground	0.9	1.1	3.1	-1.8	-0.5	-0.0
Mean time to correctly identify matches	0.9	1.6	3.1	-1.2	-0.6	-1.8
Medication: Aspirin	0.9	1.1	2.9	0.6	-1.7	0.4
Supplements: Vitamin C	0.9	1.1	1.6	1.2	-1.3	0.0
Smoking status: Previous	0.9	1.4	1.4	-1.1	-1.2	-1.2
Osteoarthritis (self-reported)	0.9	1.2	1.7	-1.1	-1.3	-0.8
Medication: Gliclazide	0.9	1.0	2.3	0.8	-1.5	0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.1	0.7	0.9	-1.4
Eye problems/disorders: Glaucoma	0.9	1.1	2.8	0.5	-0.4	1.7
Age started oral contraceptive pill	0.9	1.1	1.7	-0.2	1.3	-1.3
Myopia	0.9	1.3	2.3	1.2	0.5	1.5
Heart disease (siblings)	0.9	1.1	2.2	-0.5	-1.5	-0.9
Depression (Nagel 2018)	0.8	1.1	2.8	-0.3	-1.7	-0.7
Neuroticism (2016)	0.8	1.1	2.5	-0.3	-0.9	-1.6
Blood White Count	0.8	6.0	11.9	2.0	-1.4	3.5
Height	0.8	15.1	43.7	-0.3	-1.2	-6.6
Type 2 Diabetes (T2D) (2018)	0.8	1.6	4.1	0.4	-2.0	0.6
Hand grip strength (left)	0.8	2.1	5.2	0.7	0.8	-2.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	0.9	-0.7	1.4
Average weekly fortified wine intake	0.8	0.9	2.3	-0.1	0.6	-1.5
Falls in the last year	0.8	1.1	3.0	-1.7	0.5	0.0
Prospective memory result	0.8	1.0	2.7	-0.4	-1.6	-0.3
Standing height	0.8	8.3	23.7	-1.1	-0.2	-4.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.9	-0.3	2.0	0.1
Glaucoma (self-reported)	0.8	0.9	1.6	1.3	0.3	1.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.9	-0.3	-1.0	2.0
Eye problems/disorders: None of the above	0.8	1.0	1.4	-1.2	-0.9	0.9
Suffer from ‘nerves’	0.8	1.2	3.3	0.3	-0.6	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	0.9	-0.1	1.4
Illnesses of father: Heart disease	0.8	1.2	1.7	-0.8	1.0	-1.3
Average weekly champagne plus white wine intake	0.8	1.2	1.8	0.2	1.3	1.3
Guilty feelings	0.8	1.2	2.9	-0.9	-1.7	-0.2
Commuting to job workplace: Public transport	0.8	1.0	2.7	-0.3	-0.2	-1.7
Alcohol drinker status: Never	0.8	0.9	2.7	0.3	0.1	1.6
Average weekly beer plus cider intake	0.8	1.2	1.7	-0.5	-1.3	1.3
Risk taking	0.8	1.1	2.1	-0.2	-1.5	1.1
Basal cell carcinoma (self-reported)	0.8	0.9	1.5	-1.1	1.2	-0.1
Vitamin and mineral supplements	0.7	1.0	2.0	-0.7	-0.8	1.4
Supplements: Glucosamine	0.7	1.0	1.5	-0.6	1.0	-1.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	-1.1	-0.4	-1.0
Forced vital capacity (FVC)	0.7	2.6	2.9	1.7	-1.7	-1.4
Financial difficulties in last 2 years	0.7	0.9	2.6	0.2	-1.6	-0.3
Fluid intelligence score	0.7	1.6	4.0	-0.8	-0.2	2.0
Medication: Paracetamol	0.7	1.1	2.0	1.4	0.3	1.1
Medication: Omeprazole	0.7	0.8	1.4	1.2	-0.3	1.0
Comparative height size at age 10	0.7	3.9	8.8	-1.7	-0.0	-3.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	-1.2	-0.8	-0.6
Illnesses of siblings: Diabetes	0.7	0.8	2.2	-1.5	0.3	0.4
Ever had bowel cancer screening	0.7	0.8	1.5	-0.1	-0.9	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.8	0.5	1.7	0.4
Bipolar Disorder or Schizophrenia	0.6	1.4	3.2	-1.8	-0.6	-0.7
Depressed Affect (Nagel 2018)	0.6	1.3	1.3	-1.1	-1.1	-1.1
Reaction Time	0.6	1.2	1.9	-1.0	-0.7	-1.4
Fasting Glucose	0.6	0.7	1.5	-0.3	-1.2	-0.7
HDL Cholesterol	0.6	0.9	2.5	-0.5	0.3	1.6
Sensitivity / hurt feelings	0.6	1.0	1.5	0.0	-1.2	1.2
Impedance of leg (right)	0.6	3.1	5.3	-0.5	-1.9	-2.3
Trunk fat percentage	0.6	2.3	3.5	-1.8	-1.9	-0.2
Body mass index (BMI)	0.6	2.5	7.4	-0.3	-0.3	2.7
Impedance of leg (left)	0.6	2.9	5.5	0.5	-2.3	-1.7
Medication: Ramipril	0.6	0.8	1.6	1.3	-0.8	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.5	2.1	-1.1	0.2
Forced vital capacity (FVC), Best measure	0.6	2.1	3.1	1.5	-1.0	-1.8
Wheeze or whistling in the chest in last year	0.6	1.0	3.0	-1.7	-0.1	0.2
Emphysema/chronic bronchitis	0.6	0.7	1.9	-1.4	0.4	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	-0.6	0.9	-1.4
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.2	0.2	-1.0	1.1
Eye problems/disorders: Cataract	0.6	0.7	1.2	1.1	-0.4	-0.9
Leg fat percentage (left)	0.6	2.0	3.8	0.1	-1.5	2.0
LDL Cholesterol	0.5	0.8	2.2	-0.3	-1.5	0.2
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.1	-0.5	1.1	-0.5
Blood Eosinophil Count	0.5	3.8	9.6	0.5	1.3	3.1
Relative age of first facial hair	0.5	1.0	2.6	-1.6	-0.1	0.6
Neuroticism score	0.5	1.0	2.6	-0.3	-0.3	-1.6
Arm fat percentage (right)	0.5	2.2	5.1	-2.3	-1.0	0.5
Illnesses of mother	0.5	0.6	1.3	-1.2	-0.1	-0.6
Birth weight of first child	0.5	0.9	2.1	0.4	-0.6	1.4
Body fat percentage	0.5	1.8	3.1	-1.5	-1.8	0.5
Leg fat percentage (right)	0.5	1.7	2.5	-0.3	-1.6	1.6
Medication: Ibuprofen	0.5	0.6	1.3	0.0	1.1	0.7
Age at last live birth	0.5	0.7	1.4	-0.8	-1.2	0.4
Knee pain experienced in last month	0.5	0.8	2.1	-1.5	0.0	-0.6
Arm fat percentage (left)	0.5	2.2	4.3	-2.1	-1.2	0.8
Mood swings	0.5	0.8	1.5	0.7	0.7	-1.2
Breast cancer (self-reported)	0.5	0.6	0.8	-0.6	-0.9	0.9
Ever taken oral contraceptive pill	0.5	0.6	0.8	-0.8	0.6	-0.9
Mean Putamen Volume	0.4	0.5	1.0	-1.0	0.1	-0.6
Respiratory disease	0.4	0.8	1.4	-1.2	1.0	-0.3
Number of treatments/medications taken	0.4	0.7	1.1	1.1	-0.8	0.5
Systolic blood pressure, automated reading	0.4	1.2	1.9	1.4	-1.0	0.9
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.9	-0.1	0.6
Hand grip strength (right)	0.4	1.0	1.6	1.2	0.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	-0.5	-1.1	-0.2
Trunk fat mass	0.4	1.7	3.1	-1.8	-1.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	-0.8	-0.3	-1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-1.2	0.3	0.3
Alcohol intake versus 10 years previously	0.4	0.6	0.9	-0.5	-0.9	-1.0
Happiness	0.4	0.5	0.9	0.7	-0.4	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.2	1.0	0.6
Gout (self-reported)	0.4	0.6	1.3	0.7	-0.3	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.6	0.8	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.6	-1.0	-0.3	-1.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	1.0	-0.1	0.7
Alcohol drinker status: Previous	0.4	0.4	0.7	0.7	0.3	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.2	0.2	1.0
Ulcerative Colitis (UC)	0.3	0.5	0.8	-0.9	-0.8	0.1
Lupus	0.3	0.4	1.3	-0.0	-1.1	-0.1
Waist Hip Ratio (WHR)	0.3	1.4	2.6	-1.6	-0.3	-1.3
Neuroticism	0.3	0.7	2.0	-0.1	-0.4	-1.4
Medication: Metformin	0.3	0.4	0.6	0.5	-0.5	0.8
Fed-up feelings	0.3	0.6	1.0	-0.8	0.4	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	1.0	1.0	-0.3	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.9	0.6	-0.1
Sitting height	0.3	2.4	6.9	0.3	-0.5	-2.6
Waist circumference	0.3	1.0	2.1	-1.4	-0.7	0.8
Allergy	0.3	0.7	1.4	0.4	1.2	-0.7
Diabetes (self-reported)	0.3	0.4	0.9	0.4	-0.4	0.9
Illnesses of siblings	0.3	0.5	1.0	-1.0	-0.6	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.4	0.8	0.5	0.9	0.6
Medication: Cholesterol lowering	0.3	0.5	1.1	1.1	-0.5	-0.1
Medication: Lansoprazole	0.3	0.4	0.6	-0.0	0.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.5	1.6	-0.5	-0.4
Exposure to tobacco smoke at home	0.3	0.4	0.8	-0.1	-0.5	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.2	0.1	1.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.7	0.8	0.4
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.1	0.8	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.3	0.9	-0.5
Whole body fat mass	0.3	1.1	1.8	-1.3	-1.3	0.2
Leg fat mass (right)	0.3	1.2	1.7	-0.5	-1.3	1.3
Chest pain or discomfort	0.3	0.4	0.6	-0.1	-0.7	-0.8
Diabetes diagnosed by doctor	0.3	0.5	0.7	0.7	-0.5	0.9
Back pain experienced in last month	0.3	0.5	1.3	0.1	0.4	-1.1
Arm fat mass (left)	0.3	1.2	2.3	-1.5	-0.8	0.7
Medication: Atorvastatin	0.3	0.3	0.4	-0.7	-0.6	0.5
Pain experienced in last month	0.3	0.6	0.9	0.5	0.7	1.0
Leg fat mass (left)	0.3	1.4	2.2	-0.4	-1.3	1.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.3	1.2	-0.3	0.2
Major Depression (MDD)	0.2	0.2	0.4	0.1	-0.4	0.7
Ulcerative Colitis	0.2	0.2	0.7	-0.8	0.2	0.0
Allergy or Eczema	0.2	0.4	0.8	-0.9	0.3	-0.7
Diabetes (father)	0.2	0.2	0.7	0.8	0.1	-0.1
Maternal smoking around birth	0.2	0.2	0.5	-0.7	-0.3	-0.2
Hip circumference	0.2	0.9	1.8	-0.8	-0.4	1.4
Depression (self-reported)	0.2	0.3	0.5	0.4	-0.4	0.7
Lung cancer (father)	0.2	0.2	0.5	0.3	-0.1	-0.7
Arm fat mass (right)	0.2	1.0	2.0	-1.4	-0.8	0.7
Tense / ‘highly strung’	0.2	0.4	0.7	0.5	-0.8	0.5
Peak expiratory flow (PEF)	0.2	0.4	0.7	0.8	-0.5	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.7	-0.1	-0.5
Birth weight	0.2	0.4	1.3	1.1	0.0	-0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.4	-0.4	0.5
Heart disease (mother)	0.2	0.2	0.5	-0.7	0.2	0.1
Pulse rate, automated reading	0.2	0.5	0.8	0.6	0.6	0.9
Leg pain on walking	0.2	0.3	0.5	0.5	0.3	0.7
Hearing aid user	0.2	0.2	0.6	-0.1	0.3	-0.8
Irritability	0.2	0.3	0.6	-0.7	0.1	0.7
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.6	0.6	-0.2
Supplements: Calcium	0.2	0.3	0.7	-0.1	0.2	0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.3	0.2	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.2	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.4	0.2	0.8
Ovarian Cancer	0.1	0.2	0.2	0.4	-0.4	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.5	-0.0	0.0
Rheumatoid Arthritis	0.1	0.2	0.5	0.3	-0.7	-0.1
Hair Pigment	0.1	4.1	11.4	0.4	-0.9	3.4
Tanning	0.1	1.5	4.0	-0.1	0.7	-2.0
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	0.5	-0.4	-0.4
Supplements: Zinc	0.1	0.1	0.2	0.1	-0.3	-0.4
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	0.4	0.1
Trunk fat-free mass	0.1	0.4	1.1	0.1	1.1	0.1
Trunk predicted mass	0.1	0.4	1.1	0.1	1.1	-0.1
Length of working week for main job	0.1	0.2	0.2	0.1	0.5	0.5
Headache pain in last month	0.1	0.2	0.3	0.5	0.4	0.3
Arm fat-free mass (right)	0.1	0.6	1.0	1.0	0.5	0.8
Worry too long after embarrassment	0.1	0.1	0.2	-0.1	0.4	-0.4
Age at first live birth	0.1	0.2	0.4	-0.6	0.3	0.2
Arm predicted mass (right)	0.1	0.4	0.7	0.7	0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	0.0	0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.1	0.1	-0.4	-0.4
Asthma (self-reported)	0.1	0.2	0.6	-0.2	-0.0	0.8
Arm fat-free mass (left)	0.1	0.4	0.7	0.4	0.4	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Leg fat-free mass (left)	0.0	0.2	0.2	-0.5	0.5	-0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.4	-0.1	0.2
Leg predicted mass (left)	0.0	0.2	0.2	-0.5	0.5	-0.2
Weight	0.0	0.2	0.4	-0.7	-0.3	0.5
Father’s age at death	0.0	0.1	0.1	-0.2	-0.2	0.3
Asthma	0.0	0.1	0.2	-0.1	-0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.2	0.2	-0.0
Had major operations	0.0	0.0	0.0	-0.1	0.2	-0.2
Whole body fat-free mass	0.0	0.3	0.8	0.2	0.9	0.1
Leg fat-free mass (right)	0.0	0.1	0.3	0.0	0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.1	0.2	0.1
Whole body water mass	0.0	0.2	0.7	0.0	0.8	0.1
Leg predicted mass (right)	0.0	0.1	0.3	-0.0	0.5	0.0
Basal metabolic rate	0.0	0.1	0.2	-0.1	0.4	0.2
Arm predicted mass (left)	0.0	0.2	0.5	0.4	0.3	0.7

Hub : Genes

TMEM88

Models

Trait associations