Hub : Genes

CD68

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.3000	0.0570	1.6e-08	0.190	NA	0.151	NA	0.167	8.9e-13	NA	2.5e-10	NA	2.5e-11
2	GTEx	Liver	0.4460	0.1410	7.3e-03	-0.010	NA	-0.011	NA	-0.005	8.0e-01	NA	9.8e-01	NA	4.7e-01
3	YFS	Blood	0.0321	0.0107	2.8e-04	0.014	0.006	0.001	NA	0.006	1.9e-05	4.3e-03	9.1e-02	NA	3.4e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0490	0.0205	8.7e-06	0.045	0.049	0.041	NA	0.040	7.1e-06	2.8e-06	1.9e-05	NA	2.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	4.4	6.9	13.4	3.7	-1.4	-0.6	-3.5
Bipolar Disorder or Schizophrenia	0.9	2.3	2.9	1.7	-1.0	-1.7	-1.6
Depressed Affect (Nagel 2018)	0.4	0.9	2.4	0.6	-1.6	0.7	-0.5
Depression (Nagel 2018)	0.2	0.4	1.2	0.3	-0.0	1.1	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.6	1.3	-0.1	1.6	-1.0
Neuroticism (Nagel 2018)	0.2	0.6	0.9	1.0	-0.9	0.4	-0.7
Schizophrenia (2018)	0.5	1.0	2.9	-0.8	-0.2	-1.7	0.8
Schizophrenia vs Biploar Disorder	2.7	3.5	3.9	-1.9	1.8	-1.8	2.0
Worry (Nagel 2018)	0.2	0.3	1.1	0.2	0.5	1.0	0.2
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	-0.8	0.5	-0.8	1.3
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.3	-0.5	-0.6	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	-0.8	-0.0	-1.0	1.4
Crohns Disease (2017)	0.7	1.5	3.6	-1.1	-1.9	-0.8	0.8
Irritable Bowel Disease (IBD)	0.7	1.7	5.4	0.3	-2.3	-1.1	-0.0
Ulcerative Colitis (UC)	0.8	1.5	3.8	1.3	-2.0	-0.5	-0.6
Major Depression (MDD)	0.2	0.2	0.6	0.8	0.1	0.0	-0.5
Reaction Time	0.5	1.0	4.0	-0.1	-2.0	0.3	-0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.2	1.0	-0.5	1.5	-1.0
Breast Cancer	1.8	4.4	16.5	0.3	0.8	-4.1	-0.5
Ovarian Cancer	0.1	0.2	0.4	0.4	0.2	0.2	-0.6
Prostate Cancer	3.5	4.9	11.2	-2.4	0.1	3.4	1.6
Age at First Birth	0.7	1.1	1.8	1.3	0.9	-0.2	-1.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	1.4	0.3	-1.0	-0.7
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.4	1.3	-0.0	-1.1	-0.3	-0.2
Mean Putamen Volume	0.3	0.3	0.9	-0.1	0.5	0.9	0.2
Fasting Glucose	0.4	0.5	1.0	-0.7	-0.1	1.0	0.7
HbA1C	0.2	0.2	0.3	0.3	0.4	0.6	0.3
HDL Cholesterol	2.5	4.2	8.9	1.9	3.0	-0.8	-2.0
LDL Cholesterol	0.1	0.1	0.2	-0.1	0.2	-0.4	0.3
Lupus	4.1	6.3	11.5	-3.4	-2.9	0.1	2.3
Neuroticism (2016)	0.9	1.3	2.0	-1.2	0.5	-1.2	1.4
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.4	-0.1	-0.7	0.4
Rheumatoid Arthritis	0.3	0.3	0.7	-0.1	-0.9	0.2	-0.8
Schizophrenia (2014)	0.2	0.5	1.8	0.3	-0.4	-1.3	-0.3
Triglycerides	0.5	0.8	1.5	-0.5	-0.3	1.2	1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	1.1	-1.0	0.6	0.0
Ulcerative Colitis	1.6	2.4	6.6	1.4	-2.6	0.1	-0.9
Blood Eosinophil Count	1.4	10.6	26.3	5.1	1.9	0.4	-3.5
Blood Platelet Count	1.1	13.2	31.7	1.4	-5.6	3.9	-1.9
Blood Red Count	0.5	4.7	11.6	1.6	2.0	3.4	0.7
Blood White Count	0.9	7.0	15.9	1.1	-4.0	3.0	-1.4
Heel T-Score	3.4	26.7	55.4	7.4	3.9	-3.7	-4.8
BMI	0.4	2.5	5.4	-1.5	-1.1	-1.0	2.3
Height	0.6	11.5	32.9	-5.7	-0.5	3.6	-0.3
Waist Hip Ratio (WHR)	0.4	1.9	6.3	-0.9	-2.5	0.5	0.3
Systolic Blood Pressure	2.0	10.2	23.0	-3.3	1.1	2.3	4.8
Smoking Status	0.3	0.8	2.0	0.5	1.4	-0.9	-0.3
Allergy or Eczema	0.4	1.1	2.1	-1.3	-1.5	-0.7	0.6
Cardiovascular Disease	1.4	4.7	7.6	-1.9	-0.9	2.6	2.8
Hypothyroidism (self reported)	0.1	0.3	1.1	-0.2	0.2	-1.1	0.1
Respiratory disease	0.7	1.5	2.5	-1.5	-0.8	-1.6	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.9	-0.5	-0.2	0.7
Lung FEV1/FVC ratio	1.4	7.3	17.6	4.2	-0.9	0.1	-3.3
Lung FVC	0.7	3.3	7.2	2.7	1.4	1.4	-1.4
Neuroticism	0.4	1.0	3.5	0.7	-0.1	1.9	-0.3
Chronotype (morning person)	0.2	0.4	0.5	-0.5	-0.7	0.5	0.7
Hair Pigment	0.0	1.2	2.2	-0.8	-1.2	0.6	1.5
Tanning	0.1	0.7	2.3	0.3	0.6	1.5	-0.2
Hand grip strength (left)	0.4	1.0	1.4	-0.5	1.1	1.2	-1.0
Number of treatments/medications taken	0.3	0.6	0.9	-0.6	1.0	0.3	1.0
Average weekly spirits intake	0.3	0.3	0.5	0.7	0.3	0.6	-0.6
Sensitivity / hurt feelings	1.6	2.7	6.1	2.5	0.5	0.9	-2.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.2	0.3	1.0	1.1
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.5	-0.1	0.5	-0.2
Relative age of first facial hair	0.6	1.3	1.8	1.3	1.2	-1.3	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	-0.1	-0.5	0.5	0.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	-1.4	0.9	-0.6	0.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.1	-0.6	0.9	1.0	0.9
Systolic blood pressure, automated reading	2.4	6.8	15.8	-2.9	1.3	1.1	4.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	-1.1	-0.6	-1.4	0.5
Angina	1.1	1.4	2.3	1.2	-0.5	-1.5	-1.4
Medication for hormone replacement therapy	0.2	0.2	0.6	0.3	0.1	-0.3	-0.8
Vitamin and mineral supplements	0.2	0.3	1.1	0.1	-0.4	0.0	1.0
Supplements: Zinc	0.1	0.1	0.1	-0.2	0.2	0.3	-0.2
Medication: Co-codamol	1.2	1.4	2.2	-1.3	-1.3	0.1	1.5
Medication: Metformin	0.4	0.6	2.0	-0.6	0.2	-1.4	0.2
Diabetes (father)	0.2	0.3	0.6	0.3	-0.5	0.3	-0.8
Diabetes (mother)	0.8	1.0	1.7	-1.2	-1.3	-0.1	0.9
Severe depression (siblings)	0.1	0.1	0.2	0.2	0.4	-0.1	-0.3
Pack years adult smoking proportion	0.8	1.2	3.0	1.1	-1.7	-0.3	-0.6
Impedance of leg (right)	0.3	1.6	4.4	-1.0	0.8	0.5	2.1
Leg fat-free mass (left)	0.3	1.5	2.9	-1.7	-0.7	1.6	-0.6
Trunk fat percentage	0.9	3.4	6.6	-1.9	1.1	-1.5	2.6
Hand grip strength (right)	0.9	2.5	5.3	0.8	1.7	1.0	-2.3
Townsend deprivation index at recruitment	0.8	1.1	2.4	-1.0	-1.0	-0.4	1.5
Current tobacco smoking	0.3	0.6	1.4	0.7	-1.2	-0.4	-0.5
Average weekly fortified wine intake	1.3	1.5	2.5	1.2	1.6	-0.6	-1.4
Maternal smoking around birth	0.2	0.3	0.6	-0.5	0.8	-0.5	-0.1
Fed-up feelings	0.3	0.6	1.6	-0.2	-0.4	1.3	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.2	-0.0	0.6	0.5
Relative age voice broke	1.4	2.1	2.7	1.5	1.5	-1.1	-1.6
Taking other prescription medications	0.1	0.2	0.6	0.1	0.8	-0.0	0.3
Age when periods started (menarche)	1.9	4.5	7.1	-2.7	-0.2	2.4	2.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.1	0.2	0.4	0.3	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	7.0	2.6	1.1	-1.7	-2.1
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	7.9	-0.3	-0.4	-2.8	-0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.1	0.3	0.5	0.6
Serious illness, injury or assault to yourself	1.2	1.4	4.5	0.3	-1.0	-2.1	-0.5
High blood pressure	3.3	9.3	17.9	-3.2	1.4	2.7	4.2
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.9	-1.3	-1.7	-0.8	0.9
Multivitamins +/- minerals	0.3	0.4	1.1	-0.7	1.0	0.3	-0.4
Stomach or abdominal pain in last month	0.4	0.5	1.0	1.0	0.9	0.3	-0.3
Supplements: Glucosamine	0.6	0.8	1.9	-0.9	1.4	-0.7	0.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.2	1.8	1.1	0.4	-1.1
Medication: Atenolol	1.0	1.3	3.3	-0.6	1.8	0.5	1.1
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.1	-0.4	-0.5	-0.1
Sitting height	1.5	10.7	21.7	-4.7	-0.3	4.4	1.4
Chronic bronchitis/emphysema (father)	1.1	1.3	2.8	-1.7	0.1	-1.2	1.0
High blood pressure (mother)	1.7	2.4	7.4	-0.2	-0.8	2.7	1.2
Body mass index (BMI)	0.1	0.2	0.4	-0.4	-0.4	-0.6	0.6
Impedance of leg (left)	0.3	1.2	2.7	-0.8	0.7	1.0	1.6
Leg predicted mass (left)	0.3	1.6	2.9	-1.7	-0.7	1.6	-0.6
Trunk fat mass	0.6	2.6	5.7	-2.4	0.4	-0.5	2.0
Waist circumference	0.3	1.2	2.9	-1.7	-0.9	-0.0	1.1
Number of incorrect matches in round	0.3	0.4	1.1	-0.2	1.1	-0.4	0.7
Past tobacco smoking	0.7	1.3	2.0	-0.9	-1.0	1.4	1.2
Alcohol usually taken with meals	2.1	3.4	7.8	2.4	0.3	0.1	-2.8
Nervous feelings	0.1	0.2	0.5	-0.3	0.1	-0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.3	1.2	-1.5	1.2	-0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.2	0.6	0.1	-0.9	-1.1
Hair/balding pattern: Pattern 2	1.0	1.2	2.9	-1.3	0.4	-0.4	1.7
Had menopause	0.5	0.6	0.9	-0.8	0.8	-0.5	1.0
Had other major operations	2.1	2.5	6.8	-0.3	2.6	-1.2	1.3
Forced vital capacity (FVC)	0.5	1.8	5.9	0.9	0.0	0.6	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	6.1	2.5	1.2	-0.3	-1.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	1.0	0.1	-0.3	-0.4
Qualifications: None of the above	1.4	2.9	4.7	-1.6	-2.1	-0.3	2.2
Financial difficulties in last 2 years	0.1	0.2	0.6	0.8	-0.0	0.0	-0.4
Mouth/teeth dental problems	1.5	2.3	4.2	-2.1	1.1	-0.7	1.8
Heart attack	2.2	2.9	4.0	1.6	-1.7	-2.0	-1.5
Allergy	1.4	3.3	5.3	2.3	2.1	1.0	-1.6
Pain all over the body in last month	0.3	0.3	0.7	-0.3	0.8	-0.6	0.4
Diabetes (self-reported)	0.1	0.1	0.4	0.1	-0.3	-0.6	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.5	-0.6	-1.2	0.5	0.2
Medication: Ramipril	0.3	0.3	0.9	0.5	-0.3	0.9	-0.4
Medication: Simvastatin	0.3	0.4	0.9	0.8	-0.1	0.9	0.0
Fluid intelligence score	0.4	0.7	1.1	0.8	-0.7	0.7	-1.1
Illnesses of siblings	0.9	1.3	2.1	1.5	0.7	0.6	-1.5
Neuroticism score	0.6	1.3	4.0	0.9	-0.0	2.0	-0.6
Weight	0.4	1.8	5.9	-2.4	-0.2	0.9	0.7
Impedance of arm (right)	2.0	9.1	12.9	-2.2	3.4	-2.7	3.6
Arm fat percentage (right)	0.8	3.2	5.6	-1.3	0.9	-2.4	2.1
Trunk fat-free mass	0.9	5.3	11.6	-2.2	-1.7	3.4	-1.3
Hip circumference	0.2	0.8	2.5	-1.6	0.2	0.1	0.8
Time employed in main current job	2.4	2.7	4.6	-1.5	-1.7	2.2	1.0
Alcohol intake versus 10 years previously	2.2	3.3	10.5	-1.4	-3.2	-0.0	0.8
Father’s age at death	0.6	0.8	2.3	-0.7	1.5	-0.7	-0.1
Worrier / anxious feelings	0.6	1.0	1.9	1.4	-1.2	0.4	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	0.3	0.2	0.9	0.4
Falls in the last year	0.8	1.1	2.1	1.4	1.4	-0.2	-0.6
Hair/balding pattern: Pattern 3	0.8	1.2	2.3	-1.3	-1.5	-0.1	0.8
Number of live births	0.2	0.3	0.5	0.7	-0.7	-0.4	0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	8.4	2.0	0.3	0.7	-2.9
Pulse rate	0.9	1.5	4.8	-0.2	-1.1	2.2	-0.3
Happiness	1.3	1.6	3.8	-0.5	1.9	-0.7	1.4
Noisy workplace	1.1	1.3	4.5	-0.2	-2.1	-0.9	0.3
Qualifications: A levels/AS levels or equivalent	1.5	3.4	7.9	2.0	0.9	0.8	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.3	-0.4	-0.9	0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	0.3	-1.5	-0.8	-0.4
Asthma	0.6	1.1	2.5	-1.1	-0.8	-1.6	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	-0.8	0.3	-0.7	0.5
Medication: Cholesterol lowering	1.7	2.6	3.9	2.0	-1.3	1.2	-1.8
Depression (self-reported)	0.8	1.0	2.5	1.6	-0.3	0.2	-1.2
Medication: Lansoprazole	1.0	1.1	2.2	1.5	1.2	-0.2	-0.9
Prospective memory result	2.0	2.5	5.3	-1.6	-1.4	0.4	2.3
Lung cancer (father)	0.3	0.3	0.8	-0.5	-0.2	0.5	0.9
Illnesses of mother	0.3	0.4	0.7	0.3	0.7	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	6.9	1.5	0.2	0.7	-2.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	-1.2	-0.2	0.7	0.9
Impedance of arm (left)	1.6	7.2	10.7	-1.1	3.3	-3.0	2.8
Arm fat mass (right)	0.5	1.9	3.9	-2.0	0.5	-0.7	1.7
Trunk predicted mass	0.9	5.2	11.5	-2.1	-1.7	3.4	-1.4
Standing height	0.9	8.7	21.3	-4.6	0.1	3.6	0.4
Length of working week for main job	1.0	1.1	3.2	-0.0	-1.8	-0.7	-0.8
Exposure to tobacco smoke at home	0.4	0.4	0.6	-0.8	-0.3	-0.7	0.6
Breastfed as a baby	0.6	0.7	2.1	0.3	0.7	1.5	0.1
Tense / ‘highly strung’	0.4	0.7	1.3	-1.0	0.4	0.5	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.0	0.5	-0.9	0.2
Hair/balding pattern: Pattern 4	1.0	2.4	5.2	1.4	-0.7	2.3	-1.3
Birth weight of first child	0.6	1.1	3.6	-1.9	-0.9	0.1	0.2
Peak expiratory flow (PEF)	1.7	4.0	9.7	2.4	0.2	-0.9	-3.1
Pulse wave reflection index	0.8	0.9	2.4	0.6	1.6	-0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	-0.0	0.9	-1.0	0.2
Loud music exposure frequency	0.6	0.7	2.0	0.1	-0.8	-1.4	0.1
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	7.8	2.6	-0.2	0.8	-2.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.4	0.9	-1.8	2.1	-0.7
Blood clot in the leg (DVT)	1.3	1.7	4.1	-0.8	-2.0	-0.1	1.4
Medication: Paracetamol	0.3	0.5	1.4	-0.6	-0.2	-0.5	1.2
Headache pain in last month	0.3	0.5	0.9	1.0	-0.4	0.9	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.4	-0.1	0.4	-1.5	-0.4
Glaucoma (self-reported)	0.6	0.7	2.0	1.4	-0.6	0.1	-0.7
Gout (self-reported)	0.9	1.2	3.2	-0.5	-0.2	1.8	1.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.1	-0.3	-0.1	0.4
Medication: Amlodipine	2.6	3.6	7.6	-1.0	0.8	2.3	2.8
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.2	-0.0	-0.0	-0.5	-0.1
Birth weight	1.3	2.8	5.5	1.3	0.1	2.4	-1.9
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.8	-1.1	1.1	-1.3	1.1
High blood pressure (siblings)	0.6	0.9	1.6	-1.0	-0.5	0.7	1.3
Forced vital capacity (FVC), Best measure	0.4	1.4	4.2	0.6	0.2	0.9	-2.1
Body fat percentage	0.6	2.3	4.7	-1.4	0.7	-1.5	2.2
Leg fat percentage (right)	0.2	0.9	2.3	-0.7	-0.5	-0.7	1.5
Arm fat-free mass (right)	0.9	4.4	10.8	-1.5	-1.7	3.3	-1.3
Exposure to tobacco smoke outside home	0.5	0.7	1.7	-1.3	-0.6	0.4	0.8
Comparative body size at age 10	0.6	1.7	3.5	1.7	-0.4	0.5	-1.9
Number of full brothers	0.9	1.1	3.4	0.8	-0.4	-1.9	-0.6
Worry too long after embarrassment	0.6	1.1	2.1	1.3	-0.8	0.3	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	-0.3	1.1	0.5	0.7
Wheeze or whistling in the chest in last year	0.9	1.6	2.7	-1.2	-1.3	-1.6	0.9
Number of children fathered	0.7	0.8	1.6	1.0	-0.3	-0.5	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.6	0.7	-0.0	-0.8	-0.8
Age at first live birth	0.3	0.6	2.3	-0.1	1.5	-0.0	0.3
Pulse wave peak to peak time	0.5	0.5	1.0	0.9	0.1	-0.5	-1.0
Health satisfaction	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.4
Shortness of breath walking on level ground	0.8	0.9	1.4	1.0	-1.2	-0.7	-0.8
Qualifications: College or University degree	0.5	1.4	2.6	1.0	1.6	-0.7	-1.2
Eye problems/disorders: None of the above	1.1	1.3	3.0	-1.1	-0.1	1.7	0.9
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.3	1.8	-0.9	-1.2	-1.1
Emphysema/chronic bronchitis	0.4	0.5	0.9	-1.0	0.2	0.4	0.9
Medication for pain relief, constipation, heartburn	1.0	1.8	2.9	1.5	-1.4	0.1	-1.7
Neck or shoulder pain in last month	1.0	1.4	4.2	0.0	-1.1	-2.1	-0.2
Medication: Blood pressure	1.9	3.3	5.1	-1.3	1.2	2.3	2.3
Angina (self-reported)	1.8	2.4	3.3	1.6	-0.6	-1.8	-1.8
Migraine (self-reported)	0.9	1.1	2.3	0.8	1.1	1.5	-0.4
Medication: Ibuprofen	0.6	0.8	1.1	-1.0	0.8	-0.9	0.8
Medication: Allopurinol	1.7	2.2	3.1	-0.9	-1.8	1.5	1.7
Medication: Omeprazole	0.2	0.2	0.4	0.4	0.1	0.6	-0.6
Medication: Seretide 50 evohaler	1.0	1.2	4.3	-0.1	2.1	0.5	0.3
Mean time to correctly identify matches	0.4	0.7	2.4	-0.6	-1.5	0.2	0.1
Heart disease (mother)	0.2	0.2	0.5	0.2	-0.3	0.7	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	0.8	0.3	0.7	-1.0
Whole body fat mass	0.4	1.6	3.4	-1.8	0.4	-0.4	1.6
Leg fat mass (right)	0.2	0.8	1.8	-1.3	-0.4	0.1	1.1
Arm predicted mass (right)	0.8	4.1	9.8	-1.3	-1.7	3.1	-1.5
Pulse rate, automated reading	1.4	4.5	7.9	0.5	-2.8	2.5	-1.9
Alcohol intake frequency.	3.4	7.8	10.0	-2.8	-2.0	3.0	3.2
Comparative height size at age 10	0.4	2.2	4.3	-2.0	-0.2	2.1	0.6
Number of full sisters	0.2	0.2	0.6	0.2	0.0	0.8	-0.4
Suffer from ‘nerves’	0.5	0.8	1.9	0.6	0.9	1.4	-0.4
Overall health rating	1.3	2.8	10.1	-0.3	-3.2	-0.9	0.2
Chest pain or discomfort	1.6	2.2	2.9	1.4	-1.3	-1.7	-1.6
Had major operations	1.4	1.7	3.6	-1.9	-0.2	0.7	1.6
Age at last live birth	0.4	0.6	1.6	0.4	1.3	-0.7	-0.5
Family relationship satisfaction	2.1	2.5	4.5	-1.9	1.3	-0.6	2.1
Leg pain on walking	1.5	1.9	2.7	-1.7	-1.7	-0.2	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	-0.8	0.8	0.1	0.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	1.1	-0.5	0.2	-1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	0.4	1.4	0.3	0.3
Medication: Aspirin	0.5	0.6	1.2	-0.5	1.0	-0.3	1.1
Supplements: Vitamin C	0.3	0.4	0.8	0.7	0.3	-0.4	-0.9
Knee pain experienced in last month	0.7	1.2	2.3	-1.5	0.4	-0.0	1.5
Hypertension (Self-reported)	2.6	7.3	15.3	-2.8	1.0	2.2	3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	0.9	0.3	0.9	-0.5
Illnesses of father: Heart disease	0.3	0.5	0.8	0.8	0.6	0.2	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.1	0.5	-0.6	-1.0	-0.4
Smoking status: Previous	0.5	0.8	2.1	0.1	1.0	-1.5	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	-0.9	-0.1	0.5	-0.9
Whole body fat-free mass	0.7	3.9	8.8	-1.9	-1.3	3.0	-1.2
Leg fat-free mass (right)	0.3	1.7	3.1	-1.6	-0.5	1.8	-0.9
Arm fat percentage (left)	0.7	2.7	6.1	-0.8	0.9	-2.5	1.9
Average weekly red wine intake	1.9	2.7	4.5	1.9	0.4	-1.6	-2.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.5	0.5	0.6	-0.4
Mood swings	1.0	1.8	4.0	0.7	-1.5	2.0	-0.6
Loneliness, isolation	0.3	0.4	1.2	0.5	0.4	1.1	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.7	-1.1	-0.6	-0.0	1.3
Ever had bowel cancer screening	0.4	0.5	0.7	-0.7	0.7	-0.8	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.6	-0.2	-0.8	-0.1	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.5	-1.2	0.3	-0.3	1.6
Friendships satisfaction	0.2	0.3	0.6	0.8	0.5	-0.5	-0.4
Qualifications: nursing, teaching	0.5	0.7	2.0	0.5	-0.8	0.0	-1.4
Commuting to job workplace: Walk	1.4	1.5	4.5	0.1	-0.9	2.1	-0.8
Eye problems/disorders: Cataract	2.7	3.1	4.6	2.1	-1.1	-2.1	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	1.3	0.3	0.2	-0.8
Medication for cholesterol	0.1	0.1	0.4	0.1	0.1	-0.2	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.7	-0.9	-1.7	0.9	0.8
Back pain experienced in last month	0.9	1.3	3.1	0.2	-1.2	-1.8	-0.7
Mineral and other dietary supplements	1.2	1.6	4.5	2.1	0.6	-0.0	-1.3
Breast cancer (self-reported)	0.5	0.6	2.2	0.2	-0.1	1.5	-0.3
Asthma (self-reported)	0.8	1.7	3.4	-1.3	-1.1	-1.8	0.4
Osteoporosis (self-reported)	0.2	0.2	0.6	0.1	0.8	-0.5	-0.0
Osteoarthritis (self-reported)	2.8	3.6	9.2	-3.0	-0.9	0.2	2.1
Medication: Aspirin	0.5	0.6	1.2	-0.6	0.9	-0.5	1.1
Medication: Gliclazide	2.6	2.9	5.5	-2.2	1.1	0.3	2.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.3	-0.3	-0.5	-0.0
Smoking status: Current	0.1	0.1	0.5	0.2	-0.7	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.6	2.6	-0.2	-0.1	-1.7
Whole body water mass	0.7	3.9	8.6	-2.0	-1.3	2.9	-1.1
Leg predicted mass (right)	0.3	1.7	3.1	-1.6	-0.6	1.8	-0.9
Arm fat mass (left)	0.3	1.3	2.3	-1.5	0.3	-0.9	1.3
Number of self-reported non-cancer illnesses	1.3	2.3	4.1	-1.6	-0.1	1.6	2.0
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.4	0.7	0.2	-0.3
Miserableness	0.4	0.8	1.4	1.2	-0.6	0.9	-0.7
Guilty feelings	0.1	0.2	0.3	0.3	0.5	0.2	0.5
Wears glasses or contact lenses	1.4	1.6	2.5	0.7	-1.6	-1.4	-1.2
Ever taken oral contraceptive pill	0.7	0.7	1.2	0.9	-0.7	-0.6	-1.1
Hearing aid user	0.7	0.8	1.3	1.0	0.1	0.9	-1.1
Mother’s age at death	0.5	0.7	1.4	0.5	0.9	-0.4	-1.2
Financial situation satisfaction	1.3	1.6	3.5	1.4	0.8	-1.9	-0.7
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.7	1.3	-1.6	-0.8	-1.6
Commuting to job workplace: Public transport	0.9	1.1	3.8	0.7	-1.9	0.1	-0.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	1.1	-1.0	-0.6	-0.6
Medication: Blood pressure	0.8	1.6	3.9	-1.2	0.3	0.9	2.0
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.1	-1.3	-1.4	-0.5	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.5	-1.9	0.0	-0.3	1.3
High cholesterol (Self-reported)	2.9	5.2	10.5	3.2	-0.9	1.2	-2.8
Medication: Bendroflumethiazide	5.2	7.8	15.0	-2.2	0.8	3.9	3.3
Medication: Paracetamol	0.2	0.4	0.6	-0.7	-0.2	-0.4	0.8
Medication: Lisinopril	1.0	1.3	3.5	-0.3	1.9	-1.0	0.8
Medication: Atorvastatin	1.2	1.4	2.2	1.3	-1.5	-0.7	-1.2
Illnesses of father: High blood pressure	0.4	0.5	1.3	-0.5	0.4	0.2	1.1
Alcohol drinker status: Never	1.0	1.2	4.1	0.3	-0.6	2.0	0.3
Ever smoked	0.6	1.0	1.5	0.6	1.0	-1.0	-1.2
Basal metabolic rate	0.6	3.2	6.2	-2.2	-1.1	2.5	-0.7
Leg fat percentage (left)	0.2	0.5	1.5	-0.5	-0.3	-0.6	1.2
Arm fat-free mass (left)	0.9	4.5	8.6	-2.2	-1.9	2.9	-0.9
Number of operations (self-reported)	0.6	0.9	2.6	-0.4	1.6	0.7	0.7
Average weekly beer plus cider intake	0.7	1.0	2.8	-1.7	0.1	0.1	1.1
Irritability	0.7	1.2	3.2	0.8	-0.6	1.8	-0.9
Risk taking	0.9	1.3	5.0	0.2	-0.5	-2.2	0.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.0	1.2	-1.0	0.9	-1.4
Fractured/broken bones in last 5 years	0.7	0.9	2.3	-1.5	0.1	-0.1	1.1
Age started oral contraceptive pill	1.3	1.6	2.7	-1.3	1.6	0.0	1.4
Diastolic blood pressure, automated reading	2.4	7.4	14.5	-3.8	-0.5	2.2	3.2
Ever depressed for a whole week	1.2	1.5	3.6	1.3	1.9	-0.8	-0.6
Unable to work because of sickness or disability	1.6	2.1	2.8	1.7	-1.6	-0.8	-1.5
Commuting to job workplace: Cycle	1.3	1.6	3.6	1.4	0.9	0.0	-1.9
Myopia	1.2	1.8	3.6	1.9	0.7	-0.5	-1.7
Vascular/heart problems diagnosed by doctor	2.4	6.4	13.3	2.8	-0.8	-2.0	-3.6
Cholesterol lowering medication	0.5	0.7	1.3	0.9	0.9	-1.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.8	0.4	1.1	1.3	-0.7
Pain experienced in last month	0.6	1.0	3.2	-0.4	-0.2	1.8	0.9
Supplements: Calcium	0.8	0.8	2.0	1.1	0.1	-0.3	-1.4
Basal cell carcinoma (self-reported)	1.2	1.4	3.3	-0.8	0.9	1.8	1.0
Heart attack/myocardial infarction (self-reported)	2.3	3.0	4.3	1.7	-1.6	-2.1	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	3.4	-1.1	-1.9	-0.1	1.8
Heart disease (siblings)	0.9	1.2	3.8	0.5	0.0	-1.9	-0.8
Alcohol drinker status: Previous	0.2	0.3	0.9	0.2	-0.4	0.9	-0.0
Pack years of smoking	0.5	0.7	2.4	0.7	-1.5	-0.1	-0.3
Impedance of whole body	0.7	3.3	6.3	-1.0	2.0	-1.5	2.5
Leg fat mass (left)	0.2	0.6	1.7	-1.3	-0.1	0.1	0.9
Arm predicted mass (left)	0.8	4.1	8.3	-2.0	-1.7	2.9	-1.0