Hub : Genes

LOC284023

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1010	0.0330	3.5e-04	0.072	0.042	0.052	0.068	0.063	3.7e-09	6.4e-06	5.5e-07	1.1e-08	3.6e-08
2	TCGA	Lung Squamous Cell Carcinoma	0.0909	0.0391	5.2e-04	0.013	0.026	0.020	NA	0.007	1.1e-02	5.5e-04	1.9e-03	NA	4.5e-02
3	TCGA	Prostate Adenocarcinoma	0.1802	0.0602	2.4e-05	0.058	0.047	0.056	NA	0.069	1.1e-06	9.8e-06	1.5e-06	NA	1.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.5	1.5	0.3	1.2	0.1
Bipolar Disorder or Schizophrenia	0.9	2.3	5.6	-2.4	-0.9	-0.7
Depressed Affect (Nagel 2018)	0.2	0.3	1.0	-1.0	0.1	0.2
Depression (Nagel 2018)	0.4	0.6	1.7	-1.3	0.4	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.5	1.6	0.2	0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-0.9	-0.2	0.3
Schizophrenia (2018)	2.6	5.5	11.1	-3.3	-2.1	-0.9
Schizophrenia vs Biploar Disorder	5.3	7.0	11.2	-3.3	-2.5	-1.9
Worry (Nagel 2018)	0.3	0.7	1.5	0.5	-0.5	-1.2
Alzheimer’s Disease (in mother)	0.3	0.3	0.4	-0.6	-0.6	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.3	0.0	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.0	0.4	0.5
Crohns Disease (2017)	0.8	1.7	2.7	-1.7	-0.5	1.5
Irritable Bowel Disease (IBD)	1.0	2.3	4.9	-2.2	-1.3	0.4
Ulcerative Colitis (UC)	0.9	1.7	3.1	-1.7	-1.2	-0.7
Major Depression (MDD)	1.8	2.2	6.7	0.1	2.6	-0.2
Reaction Time	0.9	1.7	3.7	-1.9	-0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.2	3.1	1.8	0.5	-0.5
Breast Cancer	1.2	2.8	6.2	-2.5	-1.3	-0.8
Ovarian Cancer	1.0	1.3	3.2	1.8	0.8	0.4
Prostate Cancer	7.4	10.4	20.3	3.2	0.8	-4.5
Age at First Birth	2.6	3.9	6.8	-2.2	-2.6	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	0.5	1.4	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.0	0.3	0.8
Crohns Disease (2012)	0.1	0.2	0.5	-0.7	-0.0	0.0
Mean Putamen Volume	0.9	1.0	2.0	-0.6	-1.4	-0.8
Fasting Glucose	0.7	0.8	1.9	-1.4	-0.4	-0.6
HbA1C	0.3	0.3	0.6	0.8	0.3	-0.6
HDL Cholesterol	0.2	0.4	1.0	1.0	0.0	-0.4
LDL Cholesterol	0.2	0.4	0.7	-0.5	0.9	-0.2
Lupus	0.2	0.3	0.4	-0.6	0.3	-0.6
Neuroticism (2016)	0.4	0.5	1.4	-0.1	1.2	-0.4
Primary Biliary Cirrhosis	0.3	0.4	1.0	-1.0	0.0	-0.6
Rheumatoid Arthritis	0.4	0.6	1.3	0.1	1.1	-0.7
Schizophrenia (2014)	2.3	5.1	10.3	-3.2	-2.0	-1.0
Triglycerides	1.8	2.9	4.8	0.5	2.2	1.9
Type 2 Diabetes (T2D) (2012)	2.9	3.3	9.2	0.7	-0.3	-3.0
Ulcerative Colitis	1.0	1.4	3.0	-1.7	-1.0	0.5
Blood Eosinophil Count	0.1	0.5	1.2	1.1	0.5	0.1
Blood Platelet Count	1.5	17.3	31.4	5.6	4.2	1.6
Blood Red Count	2.8	26.8	50.4	5.3	7.1	-1.5
Blood White Count	1.3	9.3	18.6	2.8	4.3	1.2
Heel T-Score	2.7	21.3	51.3	-2.2	-7.2	-2.8
BMI	0.9	5.1	10.4	2.1	3.2	-0.5
Height	0.3	6.5	9.7	-2.0	-2.4	-3.1
Waist Hip Ratio (WHR)	0.4	2.0	4.2	-1.2	0.6	2.0
Systolic Blood Pressure	2.3	11.7	16.6	2.1	4.1	3.7
Smoking Status	3.8	9.2	15.7	-4.0	-3.3	-1.0
Allergy or Eczema	0.9	2.3	5.2	-1.3	-2.3	-0.3
Cardiovascular Disease	3.7	12.3	19.3	1.2	4.4	4.0
Hypothyroidism (self reported)	1.5	3.5	9.7	-0.1	-1.0	-3.1
Respiratory disease	0.0	0.1	0.3	-0.0	-0.1	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.1	0.6	0.9
Lung FEV1/FVC ratio	0.5	2.5	4.5	1.4	-2.1	-1.1
Lung FVC	0.7	3.7	6.5	1.6	1.3	-2.5
Neuroticism	0.1	0.3	0.6	-0.3	-0.4	-0.8
Chronotype (morning person)	2.2	5.0	5.4	2.1	2.3	2.3
Hair Pigment	0.0	0.1	0.2	0.5	-0.3	-0.4
Tanning	0.3	3.5	7.9	-1.6	-2.8	0.0
Hand grip strength (left)	0.3	0.9	1.9	-0.5	-0.6	-1.4
Number of treatments/medications taken	0.5	0.9	1.7	0.7	1.3	0.6
Average weekly spirits intake	2.0	2.4	3.3	-1.5	-1.4	-1.8
Sensitivity / hurt feelings	0.4	0.6	0.8	-0.7	0.9	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	-0.8	0.3	0.9
Hearing difficulty/problems: Yes	1.3	1.9	5.5	-2.3	0.6	0.1
Relative age of first facial hair	0.3	0.6	1.4	1.2	0.6	-0.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.7	1.0	1.3	-1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.4	0.7	0.4	-1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	0.9	1.0	-0.5
Systolic blood pressure, automated reading	1.3	3.7	6.0	0.6	2.4	2.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.1	1.1	-0.1	-0.0
Angina	0.4	0.6	1.1	-1.0	-0.7	-0.3
Medication for hormone replacement therapy	1.8	2.0	3.6	-1.9	-1.3	-0.8
Vitamin and mineral supplements	1.2	1.7	3.0	-1.3	-0.6	1.7
Supplements: Zinc	0.8	0.9	1.4	-0.7	-1.2	-0.9
Medication: Co-codamol	1.2	1.4	3.1	1.1	1.8	0.0
Medication: Metformin	0.4	0.6	1.3	0.6	1.1	0.3
Diabetes (father)	0.1	0.1	0.2	-0.3	0.3	-0.4
Diabetes (mother)	0.2	0.3	0.6	0.8	-0.5	0.3
Severe depression (siblings)	0.1	0.1	0.3	0.2	-0.0	-0.5
Pack years adult smoking proportion	2.1	3.3	6.8	-0.4	1.7	2.6
Impedance of leg (right)	0.3	1.4	2.7	-1.3	0.1	1.7
Leg fat-free mass (left)	0.3	1.8	5.2	-0.4	-0.0	-2.3
Trunk fat percentage	0.1	0.3	0.6	-0.8	0.6	-0.0
Hand grip strength (right)	0.1	0.3	0.7	-0.3	-0.3	-0.8
Townsend deprivation index at recruitment	0.3	0.4	1.1	0.2	1.1	0.5
Current tobacco smoking	1.3	2.0	4.8	-2.2	-1.1	0.4
Average weekly fortified wine intake	0.5	0.6	0.9	-0.8	-0.9	-0.5
Maternal smoking around birth	2.7	3.9	8.8	-3.0	-1.6	0.7
Fed-up feelings	0.1	0.1	0.2	0.0	0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.8	-0.3	0.4	0.9
Relative age voice broke	0.5	0.8	2.1	0.3	-0.6	-1.5
Taking other prescription medications	0.4	0.7	1.9	0.2	1.4	-0.1
Age when periods started (menarche)	0.5	1.1	1.9	0.8	1.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	0.6	1.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.3	17.0	-0.9	-4.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.3	0.6	0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.6	0.8	0.2	-0.7
Serious illness, injury or assault to yourself	0.3	0.4	0.6	0.8	0.4	-0.7
High blood pressure	2.2	6.2	10.1	0.3	3.2	2.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.3	-0.9	-1.5	0.3
Multivitamins +/- minerals	0.6	0.8	2.3	0.1	0.1	-1.5
Stomach or abdominal pain in last month	1.1	1.3	3.2	-0.6	0.6	1.8
Supplements: Glucosamine	0.7	0.9	1.3	0.6	1.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-1.1	-0.5	-0.7
Medication: Atenolol	0.3	0.3	0.5	0.6	0.7	0.4
Medication: Levothyroxine sodium	1.7	2.9	7.8	-0.3	-0.9	-2.8
Sitting height	0.2	1.6	4.2	-2.1	-0.6	-0.5
Chronic bronchitis/emphysema (father)	1.4	1.6	1.7	-1.2	-1.2	1.3
High blood pressure (mother)	1.6	2.3	2.7	1.4	1.6	1.5
Body mass index (BMI)	0.3	1.2	1.9	0.7	1.4	-1.0
Impedance of leg (left)	0.2	1.1	2.7	-0.9	0.1	1.6
Leg predicted mass (left)	0.3	1.8	5.2	-0.4	-0.1	-2.3
Trunk fat mass	0.1	0.5	0.7	-0.8	0.6	-0.8
Waist circumference	0.2	0.8	1.6	-0.6	0.6	-1.3
Number of incorrect matches in round	0.3	0.5	1.5	-1.2	0.2	0.3
Past tobacco smoking	2.5	4.7	8.8	3.0	2.2	0.6
Alcohol usually taken with meals	0.1	0.2	0.5	-0.3	-0.7	-0.4
Nervous feelings	0.2	0.3	0.6	0.3	0.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.2	0.7	0.3
Hearing difficulty/problems with background noise	3.3	5.3	11.8	-3.4	-0.2	2.0
Hair/balding pattern: Pattern 2	1.7	2.1	5.5	0.7	-0.7	-2.4
Had menopause	0.9	1.2	1.9	1.4	0.5	-1.1
Had other major operations	0.9	1.1	3.1	-1.8	-0.0	-0.5
Forced vital capacity (FVC)	0.1	0.3	0.4	0.6	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	11.0	-0.6	-3.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	3.0	-0.3	1.7	0.3
Qualifications: None of the above	0.3	0.5	1.0	-0.6	1.0	0.5
Financial difficulties in last 2 years	0.6	0.8	2.2	0.1	0.4	1.5
Mouth/teeth dental problems	1.2	1.8	2.6	-1.6	1.2	1.1
Heart attack	1.2	1.5	3.8	-1.9	-0.8	-0.2
Allergy	0.3	0.7	0.8	0.9	0.7	-0.9
Pain all over the body in last month	1.5	1.6	2.9	1.7	1.3	0.3
Diabetes (self-reported)	0.2	0.3	0.4	0.7	0.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.9	-0.2	-0.9	-0.9
Medication: Ramipril	0.4	0.5	1.4	0.1	1.2	0.5
Medication: Simvastatin	0.7	1.0	2.0	0.7	0.6	1.4
Fluid intelligence score	0.1	0.1	0.2	0.4	0.2	0.5
Illnesses of siblings	1.1	1.6	2.5	-1.5	-1.6	-0.2
Neuroticism score	0.1	0.3	0.6	-0.2	-0.3	-0.8
Weight	0.2	1.2	3.1	-0.2	0.7	-1.8
Impedance of arm (right)	1.3	5.9	6.5	-2.6	-2.4	2.3
Arm fat percentage (right)	0.1	0.2	0.6	-0.8	0.0	-0.2
Trunk fat-free mass	0.5	3.1	8.3	-0.8	-0.5	-2.9
Hip circumference	0.3	1.5	4.4	-0.1	0.3	-2.1
Time employed in main current job	1.2	1.4	2.2	1.5	-0.3	-1.4
Alcohol intake versus 10 years previously	0.8	1.2	2.6	0.2	1.6	0.9
Father’s age at death	1.0	1.4	2.2	0.6	-1.3	-1.5
Worrier / anxious feelings	0.1	0.1	0.2	-0.4	-0.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	-0.1	0.7	-0.7
Falls in the last year	0.9	1.3	1.9	-1.3	-1.4	-0.1
Hair/balding pattern: Pattern 3	1.4	2.2	4.3	0.5	2.1	1.4
Number of live births	1.6	2.2	3.8	-1.1	2.0	1.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.7	1.3	0.9	-0.5
Pulse rate	0.2	0.3	0.5	0.7	-0.3	-0.6
Happiness	0.5	0.6	0.9	1.0	-0.0	-0.9
Noisy workplace	3.4	4.2	9.8	3.1	1.6	0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.2	1.7	0.9	-1.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	1.2	-1.0	0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	1.0	0.0	0.5
Asthma	0.3	0.6	1.6	0.2	-0.3	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	4.5	-0.6	-2.1	0.2
Medication: Cholesterol lowering	0.2	0.4	1.0	-0.3	0.0	1.0
Depression (self-reported)	0.4	0.5	0.8	0.4	0.9	0.7
Medication: Lansoprazole	0.3	0.3	0.4	0.7	0.1	0.6
Prospective memory result	0.3	0.4	0.8	-0.5	0.4	0.9
Lung cancer (father)	0.7	0.9	1.6	1.3	1.0	-0.2
Illnesses of mother	1.0	1.2	3.2	0.1	-0.6	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	1.0	0.2	-1.1
Pulse wave Arterial Stiffness index	1.5	1.8	4.7	2.2	0.7	-0.5
Impedance of arm (left)	0.8	3.7	4.7	-1.9	-1.6	2.2
Arm fat mass (right)	0.1	0.4	0.8	-0.4	0.4	-0.9
Trunk predicted mass	0.6	3.2	8.6	-0.8	-0.5	-2.9
Standing height	0.3	3.3	5.4	-2.3	-1.4	-1.6
Length of working week for main job	0.4	0.4	1.2	0.3	0.1	1.1
Exposure to tobacco smoke at home	0.5	0.6	0.9	-0.9	0.2	-0.9
Breastfed as a baby	0.3	0.4	0.7	0.6	-0.8	-0.5
Tense / ‘highly strung’	0.3	0.5	1.2	1.1	0.4	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	0.2	1.3	-1.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	-0.4	0.1	-0.0
Birth weight of first child	0.5	0.9	1.7	1.0	1.3	-0.4
Peak expiratory flow (PEF)	0.2	0.5	1.3	-0.2	0.5	1.1
Pulse wave reflection index	2.1	2.6	4.0	2.0	1.2	1.6
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.3	-1.2	-1.8	-0.5
Loud music exposure frequency	0.9	1.0	1.7	-1.2	0.1	-1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.2	1.2	-0.0	-1.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.4	1.5	-0.9	-1.5
Blood clot in the leg (DVT)	0.3	0.4	1.0	0.2	1.0	-0.5
Medication: Paracetamol	0.7	1.2	2.6	0.9	1.6	0.5
Headache pain in last month	0.1	0.2	0.3	0.4	-0.5	0.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	1.5	-0.2	0.1
Glaucoma (self-reported)	1.5	1.8	3.2	1.3	1.8	-0.6
Gout (self-reported)	0.8	1.0	1.6	1.2	0.2	-1.3
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	11.0	0.2	-1.0	-3.3
Medication: Amlodipine	0.4	0.5	1.4	-0.3	1.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	0.4	0.4
Birth weight	1.0	2.1	5.1	0.5	-1.0	-2.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.0	-1.7	-1.0	0.5
High blood pressure (siblings)	1.9	2.7	5.1	2.2	1.8	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.2	0.5	0.2	-1.1
Body fat percentage	0.1	0.4	1.1	-0.3	1.0	-0.2
Leg fat percentage (right)	0.4	1.4	4.1	0.4	2.0	0.3
Arm fat-free mass (right)	0.8	3.9	10.2	0.7	1.1	-3.2
Exposure to tobacco smoke outside home	0.2	0.3	0.4	-0.6	-0.5	-0.6
Comparative body size at age 10	1.8	4.8	10.6	1.0	-1.7	-3.3
Number of full brothers	0.4	0.5	0.8	0.7	0.5	0.9
Worry too long after embarrassment	0.2	0.3	0.5	0.0	-0.7	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.9	0.5	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.2	0.1	-0.7
Number of children fathered	0.1	0.2	0.2	-0.2	-0.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.3	4.6	-1.3	2.1	1.9
Age at first live birth	1.0	1.7	2.7	-1.6	-1.5	-0.5
Pulse wave peak to peak time	1.7	2.0	5.4	-2.3	-0.7	0.3
Health satisfaction	1.0	1.3	2.5	-1.2	-1.6	-0.2
Shortness of breath walking on level ground	0.7	0.9	2.1	-0.5	-1.5	-0.4
Qualifications: College or University degree	0.3	0.9	2.0	-0.5	-1.4	-0.8
Eye problems/disorders: None of the above	1.8	2.1	4.7	-2.2	-1.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	-0.6	-1.2	-0.2
Emphysema/chronic bronchitis	1.2	1.4	2.0	-1.4	-0.9	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.2	-0.2	-0.9
Neck or shoulder pain in last month	1.3	1.8	4.2	-2.0	0.6	1.0
Medication: Blood pressure	0.5	0.8	2.4	-1.5	-0.1	-0.1
Angina (self-reported)	0.4	0.5	1.3	-1.1	-0.4	-0.2
Migraine (self-reported)	0.1	0.1	0.1	0.3	0.3	0.1
Medication: Ibuprofen	0.8	0.9	2.2	-0.6	-1.5	0.5
Medication: Allopurinol	0.8	1.0	2.3	0.2	0.8	-1.5
Medication: Omeprazole	2.7	3.2	5.3	1.1	1.8	2.3
Medication: Seretide 50 evohaler	1.7	1.9	3.6	-0.5	-1.4	-1.9
Mean time to correctly identify matches	1.2	2.3	4.3	-2.1	-1.4	-0.6
Heart disease (mother)	1.5	1.9	2.9	0.4	1.6	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	0.9	0.4	1.1
Whole body fat mass	0.2	0.7	1.2	-0.4	0.7	-1.1
Leg fat mass (right)	0.2	1.0	2.2	-0.0	1.5	-0.8
Arm predicted mass (right)	0.6	3.3	8.6	0.2	1.1	-2.9
Pulse rate, automated reading	0.1	0.3	0.9	-0.1	1.0	0.2
Alcohol intake frequency.	4.1	9.5	18.3	4.3	2.7	-1.7
Comparative height size at age 10	1.1	6.1	9.6	-2.9	-3.1	-0.5
Number of full sisters	0.5	0.6	0.9	-0.3	0.9	0.9
Suffer from ‘nerves’	0.1	0.2	0.6	0.1	0.7	0.1
Overall health rating	0.2	0.4	1.1	-1.1	-0.0	-0.4
Chest pain or discomfort	0.4	0.5	1.5	0.4	1.2	0.2
Had major operations	0.7	0.8	1.2	0.7	0.9	-1.1
Age at last live birth	1.9	2.7	4.0	-2.0	-1.8	-1.0
Family relationship satisfaction	2.4	2.9	6.5	-2.5	-1.5	-0.1
Leg pain on walking	0.4	0.5	0.7	0.5	0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	0.8	0.9	-0.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.5	1.6	0.3	0.9
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.6	-1.3	-0.4	-1.0
Medication: Aspirin	0.2	0.2	0.3	-0.5	0.6	0.3
Supplements: Vitamin C	0.9	1.1	1.9	1.4	1.2	-0.0
Knee pain experienced in last month	0.8	1.2	3.0	-1.7	-0.4	0.7
Hypertension (Self-reported)	2.0	5.6	9.9	0.0	3.1	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.7	-0.0	0.8	-0.0
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.3	-0.4	-0.7
Illnesses of siblings: Diabetes	0.6	0.8	2.1	0.0	-0.5	-1.5
Smoking status: Previous	2.3	3.4	5.6	-2.4	-2.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.8	-1.3	0.1	-0.3
Whole body fat-free mass	0.4	2.6	7.5	-0.4	-0.2	-2.7
Leg fat-free mass (right)	0.3	1.5	4.5	-0.0	-0.1	-2.1
Arm fat percentage (left)	0.0	0.2	0.4	-0.3	0.6	-0.2
Average weekly red wine intake	3.3	4.9	6.6	-2.4	-1.5	-2.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	0.3	0.9	1.2
Mood swings	0.4	0.7	1.6	-0.1	-1.2	-0.7
Loneliness, isolation	1.5	2.0	5.1	-2.3	-0.9	-0.3
Long-standing illness, disability or infirmity	0.9	1.4	2.7	0.8	0.9	-1.6
Ever had bowel cancer screening	0.5	0.6	1.1	0.9	-0.1	1.1
Diabetes diagnosed by doctor	0.3	0.5	0.7	0.9	0.7	0.5
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	6.7	-2.6	-0.9	1.1
Friendships satisfaction	0.8	1.0	2.7	-1.6	-0.7	0.1
Qualifications: nursing, teaching	1.7	2.7	5.8	0.7	-1.3	-2.4
Commuting to job workplace: Walk	1.2	1.2	2.6	0.8	0.7	-1.6
Eye problems/disorders: Cataract	1.2	1.4	2.1	1.0	1.4	1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	0.6	-0.9	-0.4
Medication for cholesterol	3.2	4.9	7.3	-1.8	-2.7	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.5	-0.1	0.2
Back pain experienced in last month	0.1	0.2	0.3	-0.5	0.3	0.6
Mineral and other dietary supplements	1.6	2.2	3.7	-0.7	-1.5	1.9
Breast cancer (self-reported)	0.7	0.9	2.0	-0.8	-1.4	-0.2
Asthma (self-reported)	0.2	0.5	1.2	0.4	-0.0	1.1
Osteoporosis (self-reported)	1.1	1.3	2.2	1.3	1.5	0.2
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.2	1.1	0.3
Medication: Aspirin	0.4	0.5	1.0	-0.6	1.0	0.4
Medication: Gliclazide	0.6	0.7	1.1	1.1	1.0	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.7	0.1	-0.7
Smoking status: Current	1.2	1.9	4.0	-2.0	-1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.8	1.7	1.0	-1.2
Whole body water mass	0.5	2.6	7.6	-0.5	-0.1	-2.8
Leg predicted mass (right)	0.3	1.5	4.5	-0.1	-0.0	-2.1
Arm fat mass (left)	0.1	0.6	1.4	-0.3	0.5	-1.2
Number of self-reported non-cancer illnesses	2.3	4.0	10.2	1.3	3.2	0.1
Average weekly champagne plus white wine intake	1.1	1.6	3.2	-0.4	-1.8	1.2
Miserableness	0.2	0.3	0.8	-0.1	0.9	0.4
Guilty feelings	0.2	0.2	0.4	-0.4	-0.7	0.4
Wears glasses or contact lenses	0.1	0.1	0.2	-0.1	-0.4	-0.0
Ever taken oral contraceptive pill	2.2	2.5	6.0	-0.9	-0.8	2.5
Hearing aid user	0.0	0.0	0.1	-0.1	-0.3	-0.2
Mother’s age at death	0.4	0.5	1.3	0.1	-1.2	-0.4
Financial situation satisfaction	0.2	0.2	0.3	0.3	0.5	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.8	-0.2	-0.3
Commuting to job workplace: Public transport	1.2	1.4	3.8	-1.9	-0.3	-0.5
Eye problems/disorders: Glaucoma	2.0	2.4	6.1	0.7	2.5	0.7
Medication: Blood pressure	6.9	13.1	21.5	2.9	4.6	3.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	2.3	-1.5	0.3	-0.2
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.8	-0.2	1.2	-1.7
High cholesterol (Self-reported)	2.3	4.0	5.0	2.2	1.6	2.1
Medication: Bendroflumethiazide	4.2	6.4	10.3	2.9	3.2	0.7
Medication: Paracetamol	2.0	3.1	6.8	1.2	2.6	1.1
Medication: Lisinopril	0.3	0.4	0.6	-0.7	0.4	0.6
Medication: Atorvastatin	0.1	0.1	0.2	-0.1	0.5	-0.5
Illnesses of father: High blood pressure	0.8	1.0	2.8	0.3	1.7	0.2
Alcohol drinker status: Never	1.3	1.6	4.1	0.8	2.0	0.1
Ever smoked	2.0	3.5	5.0	-2.2	-2.2	-0.9
Basal metabolic rate	0.4	2.1	6.2	-0.4	0.1	-2.5
Leg fat percentage (left)	0.4	1.3	3.5	0.6	1.9	0.2
Arm fat-free mass (left)	0.5	2.7	8.0	-0.1	0.5	-2.8
Number of operations (self-reported)	0.7	1.0	1.4	0.7	1.2	-1.1
Average weekly beer plus cider intake	0.0	0.1	0.2	0.4	0.0	0.2
Irritability	0.9	1.6	2.8	-1.3	-1.7	-0.5
Risk taking	1.3	2.0	5.5	-0.6	-0.2	2.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	0.1	-0.8	-0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.6	0.5	0.3	-0.8
Age started oral contraceptive pill	2.2	2.8	4.5	2.1	1.3	-1.4
Diastolic blood pressure, automated reading	2.0	6.2	15.2	0.3	3.9	1.8
Ever depressed for a whole week	0.7	0.9	1.6	-0.7	-0.8	-1.3
Unable to work because of sickness or disability	2.0	2.6	5.7	-2.4	-1.5	0.2
Commuting to job workplace: Cycle	0.6	0.7	2.2	1.5	-0.1	-0.1
Myopia	1.0	1.5	3.5	0.7	-1.9	0.6
Vascular/heart problems diagnosed by doctor	1.7	4.6	7.7	-0.1	-2.5	-2.8
Cholesterol lowering medication	3.6	5.3	8.2	2.9	2.4	1.4
Medication: Omeprazole (e.g. Zanprol)	4.7	5.7	8.5	1.7	2.9	2.4
Pain experienced in last month	0.3	0.4	1.0	1.0	0.5	0.2
Supplements: Calcium	0.7	0.8	1.2	1.1	1.0	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	-0.4	-0.4	1.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.3	-1.8	-1.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.6	0.6	1.2	-0.4
Heart disease (siblings)	0.8	0.9	1.1	-0.7	1.1	1.1
Alcohol drinker status: Previous	1.3	1.4	2.6	1.3	0.2	-1.6
Pack years of smoking	2.0	3.0	6.9	-0.1	1.5	2.6
Impedance of whole body	0.6	3.0	5.1	-1.7	-1.1	2.3
Leg fat mass (left)	0.2	0.9	2.1	0.0	1.4	-0.8
Arm predicted mass (left)	0.6	2.9	8.5	-0.4	0.2	-2.9