Hub : Genes

LOC284023

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1010 0.0330 3.5e-04 0.072 0.042 0.052 0.068 0.063 3.7e-09 6.4e-06 5.5e-07 1.1e-08 3.6e-08
2 TCGA Lung Squamous Cell Carcinoma 0.0909 0.0391 5.2e-04 0.013 0.026 0.020 NA 0.007 1.1e-02 5.5e-04 1.9e-03 NA 4.5e-02
3 TCGA Prostate Adenocarcinoma 0.1802 0.0602 2.4e-05 0.058 0.047 0.056 NA 0.069 1.1e-06 9.8e-06 1.5e-06 NA 1.1e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.5 1.5 0.3 1.2 0.1
Bipolar Disorder or Schizophrenia 0.9 2.3 5.6 -2.4 -0.9 -0.7
Depressed Affect (Nagel 2018) 0.2 0.3 1.0 -1.0 0.1 0.2
Depression (Nagel 2018) 0.4 0.6 1.7 -1.3 0.4 0.2
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.5 1.6 0.2 0.1
Neuroticism (Nagel 2018) 0.1 0.3 0.9 -0.9 -0.2 0.3
Schizophrenia (2018) 2.6 5.5 11.1 -3.3 -2.1 -0.9
Schizophrenia vs Biploar Disorder 5.3 7.0 11.2 -3.3 -2.5 -1.9
Worry (Nagel 2018) 0.3 0.7 1.5 0.5 -0.5 -1.2
Alzheimer’s Disease (in mother) 0.3 0.3 0.4 -0.6 -0.6 0.5
Alzheimer’s Disease (in father) 0.1 0.1 0.3 0.3 0.0 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.0 0.4 0.5
Crohns Disease (2017) 0.8 1.7 2.7 -1.7 -0.5 1.5
Irritable Bowel Disease (IBD) 1.0 2.3 4.9 -2.2 -1.3 0.4
Ulcerative Colitis (UC) 0.9 1.7 3.1 -1.7 -1.2 -0.7
Major Depression (MDD) 1.8 2.2 6.7 0.1 2.6 -0.2
Reaction Time 0.9 1.7 3.7 -1.9 -0.9 0.8
Verbal and Numeric Reasoning (VNR) 0.5 1.2 3.1 1.8 0.5 -0.5
Breast Cancer 1.2 2.8 6.2 -2.5 -1.3 -0.8
Ovarian Cancer 1.0 1.3 3.2 1.8 0.8 0.4
Prostate Cancer 7.4 10.4 20.3 3.2 0.8 -4.5
Age at First Birth 2.6 3.9 6.8 -2.2 -2.6 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.1 0.5 1.4 -0.1
Coronary Artery Disease (CAD) 0.2 0.2 0.6 -0.0 0.3 0.8
Crohns Disease (2012) 0.1 0.2 0.5 -0.7 -0.0 0.0
Mean Putamen Volume 0.9 1.0 2.0 -0.6 -1.4 -0.8
Fasting Glucose 0.7 0.8 1.9 -1.4 -0.4 -0.6
HbA1C 0.3 0.3 0.6 0.8 0.3 -0.6
HDL Cholesterol 0.2 0.4 1.0 1.0 0.0 -0.4
LDL Cholesterol 0.2 0.4 0.7 -0.5 0.9 -0.2
Lupus 0.2 0.3 0.4 -0.6 0.3 -0.6
Neuroticism (2016) 0.4 0.5 1.4 -0.1 1.2 -0.4
Primary Biliary Cirrhosis 0.3 0.4 1.0 -1.0 0.0 -0.6
Rheumatoid Arthritis 0.4 0.6 1.3 0.1 1.1 -0.7
Schizophrenia (2014) 2.3 5.1 10.3 -3.2 -2.0 -1.0
Triglycerides 1.8 2.9 4.8 0.5 2.2 1.9
Type 2 Diabetes (T2D) (2012) 2.9 3.3 9.2 0.7 -0.3 -3.0
Ulcerative Colitis 1.0 1.4 3.0 -1.7 -1.0 0.5
Blood Eosinophil Count 0.1 0.5 1.2 1.1 0.5 0.1
Blood Platelet Count 1.5 17.3 31.4 5.6 4.2 1.6
Blood Red Count 2.8 26.8 50.4 5.3 7.1 -1.5
Blood White Count 1.3 9.3 18.6 2.8 4.3 1.2
Heel T-Score 2.7 21.3 51.3 -2.2 -7.2 -2.8
BMI 0.9 5.1 10.4 2.1 3.2 -0.5
Height 0.3 6.5 9.7 -2.0 -2.4 -3.1
Waist Hip Ratio (WHR) 0.4 2.0 4.2 -1.2 0.6 2.0
Systolic Blood Pressure 2.3 11.7 16.6 2.1 4.1 3.7
Smoking Status 3.8 9.2 15.7 -4.0 -3.3 -1.0
Allergy or Eczema 0.9 2.3 5.2 -1.3 -2.3 -0.3
Cardiovascular Disease 3.7 12.3 19.3 1.2 4.4 4.0
Hypothyroidism (self reported) 1.5 3.5 9.7 -0.1 -1.0 -3.1
Respiratory disease 0.0 0.1 0.3 -0.0 -0.1 0.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.8 0.1 0.6 0.9
Lung FEV1/FVC ratio 0.5 2.5 4.5 1.4 -2.1 -1.1
Lung FVC 0.7 3.7 6.5 1.6 1.3 -2.5
Neuroticism 0.1 0.3 0.6 -0.3 -0.4 -0.8
Chronotype (morning person) 2.2 5.0 5.4 2.1 2.3 2.3
Hair Pigment 0.0 0.1 0.2 0.5 -0.3 -0.4
Tanning 0.3 3.5 7.9 -1.6 -2.8 0.0
Hand grip strength (left) 0.3 0.9 1.9 -0.5 -0.6 -1.4
Number of treatments/medications taken 0.5 0.9 1.7 0.7 1.3 0.6
Average weekly spirits intake 2.0 2.4 3.3 -1.5 -1.4 -1.8
Sensitivity / hurt feelings 0.4 0.6 0.8 -0.7 0.9 0.8
Frequency of depressed mood in last 2 weeks 0.4 0.5 0.9 -0.8 0.3 0.9
Hearing difficulty/problems: Yes 1.3 1.9 5.5 -2.3 0.6 0.1
Relative age of first facial hair 0.3 0.6 1.4 1.2 0.6 -0.1
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 1.7 1.0 1.3 -1.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.4 0.7 0.4 -1.2
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 0.9 1.0 -0.5
Systolic blood pressure, automated reading 1.3 3.7 6.0 0.6 2.4 2.1
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.1 1.1 -0.1 -0.0
Angina 0.4 0.6 1.1 -1.0 -0.7 -0.3
Medication for hormone replacement therapy 1.8 2.0 3.6 -1.9 -1.3 -0.8
Vitamin and mineral supplements 1.2 1.7 3.0 -1.3 -0.6 1.7
Supplements: Zinc 0.8 0.9 1.4 -0.7 -1.2 -0.9
Medication: Co-codamol 1.2 1.4 3.1 1.1 1.8 0.0
Medication: Metformin 0.4 0.6 1.3 0.6 1.1 0.3
Diabetes (father) 0.1 0.1 0.2 -0.3 0.3 -0.4
Diabetes (mother) 0.2 0.3 0.6 0.8 -0.5 0.3
Severe depression (siblings) 0.1 0.1 0.3 0.2 -0.0 -0.5
Pack years adult smoking proportion 2.1 3.3 6.8 -0.4 1.7 2.6
Impedance of leg (right) 0.3 1.4 2.7 -1.3 0.1 1.7
Leg fat-free mass (left) 0.3 1.8 5.2 -0.4 -0.0 -2.3
Trunk fat percentage 0.1 0.3 0.6 -0.8 0.6 -0.0
Hand grip strength (right) 0.1 0.3 0.7 -0.3 -0.3 -0.8
Townsend deprivation index at recruitment 0.3 0.4 1.1 0.2 1.1 0.5
Current tobacco smoking 1.3 2.0 4.8 -2.2 -1.1 0.4
Average weekly fortified wine intake 0.5 0.6 0.9 -0.8 -0.9 -0.5
Maternal smoking around birth 2.7 3.9 8.8 -3.0 -1.6 0.7
Fed-up feelings 0.1 0.1 0.2 0.0 0.4 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 0.8 -0.3 0.4 0.9
Relative age voice broke 0.5 0.8 2.1 0.3 -0.6 -1.5
Taking other prescription medications 0.4 0.7 1.9 0.2 1.4 -0.1
Age when periods started (menarche) 0.5 1.1 1.9 0.8 1.4 0.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 0.6 1.6 0.1
Heel bone mineral density (BMD) T-score, automated (left) 2.8 6.3 17.0 -0.9 -4.1 -1.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 -0.3 0.6 0.2
Qualifications: CSEs or equivalent 0.3 0.4 0.6 0.8 0.2 -0.7
Serious illness, injury or assault to yourself 0.3 0.4 0.6 0.8 0.4 -0.7
High blood pressure 2.2 6.2 10.1 0.3 3.2 2.9
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.3 -0.9 -1.5 0.3
Multivitamins +/- minerals 0.6 0.8 2.3 0.1 0.1 -1.5
Stomach or abdominal pain in last month 1.1 1.3 3.2 -0.6 0.6 1.8
Supplements: Glucosamine 0.7 0.9 1.3 0.6 1.1 -0.9
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.1 -1.1 -0.5 -0.7
Medication: Atenolol 0.3 0.3 0.5 0.6 0.7 0.4
Medication: Levothyroxine sodium 1.7 2.9 7.8 -0.3 -0.9 -2.8
Sitting height 0.2 1.6 4.2 -2.1 -0.6 -0.5
Chronic bronchitis/emphysema (father) 1.4 1.6 1.7 -1.2 -1.2 1.3
High blood pressure (mother) 1.6 2.3 2.7 1.4 1.6 1.5
Body mass index (BMI) 0.3 1.2 1.9 0.7 1.4 -1.0
Impedance of leg (left) 0.2 1.1 2.7 -0.9 0.1 1.6
Leg predicted mass (left) 0.3 1.8 5.2 -0.4 -0.1 -2.3
Trunk fat mass 0.1 0.5 0.7 -0.8 0.6 -0.8
Waist circumference 0.2 0.8 1.6 -0.6 0.6 -1.3
Number of incorrect matches in round 0.3 0.5 1.5 -1.2 0.2 0.3
Past tobacco smoking 2.5 4.7 8.8 3.0 2.2 0.6
Alcohol usually taken with meals 0.1 0.2 0.5 -0.3 -0.7 -0.4
Nervous feelings 0.2 0.3 0.6 0.3 0.4 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.4 -0.2 0.7 0.3
Hearing difficulty/problems with background noise 3.3 5.3 11.8 -3.4 -0.2 2.0
Hair/balding pattern: Pattern 2 1.7 2.1 5.5 0.7 -0.7 -2.4
Had menopause 0.9 1.2 1.9 1.4 0.5 -1.1
Had other major operations 0.9 1.1 3.1 -1.8 -0.0 -0.5
Forced vital capacity (FVC) 0.1 0.3 0.4 0.6 0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.9 11.0 -0.6 -3.3 -0.7
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 3.0 -0.3 1.7 0.3
Qualifications: None of the above 0.3 0.5 1.0 -0.6 1.0 0.5
Financial difficulties in last 2 years 0.6 0.8 2.2 0.1 0.4 1.5
Mouth/teeth dental problems 1.2 1.8 2.6 -1.6 1.2 1.1
Heart attack 1.2 1.5 3.8 -1.9 -0.8 -0.2
Allergy 0.3 0.7 0.8 0.9 0.7 -0.9
Pain all over the body in last month 1.5 1.6 2.9 1.7 1.3 0.3
Diabetes (self-reported) 0.2 0.3 0.4 0.7 0.6 0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 0.9 -0.2 -0.9 -0.9
Medication: Ramipril 0.4 0.5 1.4 0.1 1.2 0.5
Medication: Simvastatin 0.7 1.0 2.0 0.7 0.6 1.4
Fluid intelligence score 0.1 0.1 0.2 0.4 0.2 0.5
Illnesses of siblings 1.1 1.6 2.5 -1.5 -1.6 -0.2
Neuroticism score 0.1 0.3 0.6 -0.2 -0.3 -0.8
Weight 0.2 1.2 3.1 -0.2 0.7 -1.8
Impedance of arm (right) 1.3 5.9 6.5 -2.6 -2.4 2.3
Arm fat percentage (right) 0.1 0.2 0.6 -0.8 0.0 -0.2
Trunk fat-free mass 0.5 3.1 8.3 -0.8 -0.5 -2.9
Hip circumference 0.3 1.5 4.4 -0.1 0.3 -2.1
Time employed in main current job 1.2 1.4 2.2 1.5 -0.3 -1.4
Alcohol intake versus 10 years previously 0.8 1.2 2.6 0.2 1.6 0.9
Father’s age at death 1.0 1.4 2.2 0.6 -1.3 -1.5
Worrier / anxious feelings 0.1 0.1 0.2 -0.4 -0.4 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.5 -0.1 0.7 -0.7
Falls in the last year 0.9 1.3 1.9 -1.3 -1.4 -0.1
Hair/balding pattern: Pattern 3 1.4 2.2 4.3 0.5 2.1 1.4
Number of live births 1.6 2.2 3.8 -1.1 2.0 1.3
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.7 1.3 0.9 -0.5
Pulse rate 0.2 0.3 0.5 0.7 -0.3 -0.6
Happiness 0.5 0.6 0.9 1.0 -0.0 -0.9
Noisy workplace 3.4 4.2 9.8 3.1 1.6 0.2
Qualifications: A levels/AS levels or equivalent 0.6 1.2 1.7 0.9 -1.3 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.4 1.2 -1.0 0.2
Mouth/teeth dental problems: Dentures 0.2 0.4 1.1 1.0 0.0 0.5
Asthma 0.3 0.6 1.6 0.2 -0.3 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 4.5 -0.6 -2.1 0.2
Medication: Cholesterol lowering 0.2 0.4 1.0 -0.3 0.0 1.0
Depression (self-reported) 0.4 0.5 0.8 0.4 0.9 0.7
Medication: Lansoprazole 0.3 0.3 0.4 0.7 0.1 0.6
Prospective memory result 0.3 0.4 0.8 -0.5 0.4 0.9
Lung cancer (father) 0.7 0.9 1.6 1.3 1.0 -0.2
Illnesses of mother 1.0 1.2 3.2 0.1 -0.6 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.2 1.0 0.2 -1.1
Pulse wave Arterial Stiffness index 1.5 1.8 4.7 2.2 0.7 -0.5
Impedance of arm (left) 0.8 3.7 4.7 -1.9 -1.6 2.2
Arm fat mass (right) 0.1 0.4 0.8 -0.4 0.4 -0.9
Trunk predicted mass 0.6 3.2 8.6 -0.8 -0.5 -2.9
Standing height 0.3 3.3 5.4 -2.3 -1.4 -1.6
Length of working week for main job 0.4 0.4 1.2 0.3 0.1 1.1
Exposure to tobacco smoke at home 0.5 0.6 0.9 -0.9 0.2 -0.9
Breastfed as a baby 0.3 0.4 0.7 0.6 -0.8 -0.5
Tense / ‘highly strung’ 0.3 0.5 1.2 1.1 0.4 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.6 0.2 1.3 -1.1
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 -0.4 0.1 -0.0
Birth weight of first child 0.5 0.9 1.7 1.0 1.3 -0.4
Peak expiratory flow (PEF) 0.2 0.5 1.3 -0.2 0.5 1.1
Pulse wave reflection index 2.1 2.6 4.0 2.0 1.2 1.6
Ever highly irritable/argumentative for 2 days 1.4 1.7 3.3 -1.2 -1.8 -0.5
Loud music exposure frequency 0.9 1.0 1.7 -1.2 0.1 -1.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.2 1.2 -0.0 -1.5
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 2.4 1.5 -0.9 -1.5
Blood clot in the leg (DVT) 0.3 0.4 1.0 0.2 1.0 -0.5
Medication: Paracetamol 0.7 1.2 2.6 0.9 1.6 0.5
Headache pain in last month 0.1 0.2 0.3 0.4 -0.5 0.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.3 1.5 -0.2 0.1
Glaucoma (self-reported) 1.5 1.8 3.2 1.3 1.8 -0.6
Gout (self-reported) 0.8 1.0 1.6 1.2 0.2 -1.3
Hypothyroidism/myxoedema (self-reported) 2.1 4.0 11.0 0.2 -1.0 -3.3
Medication: Amlodipine 0.4 0.5 1.4 -0.3 1.2 -0.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.9 0.4 0.4
Birth weight 1.0 2.1 5.1 0.5 -1.0 -2.3
Chronic bronchitis/emphysema (mother) 1.2 1.4 3.0 -1.7 -1.0 0.5
High blood pressure (siblings) 1.9 2.7 5.1 2.2 1.8 -0.2
Forced vital capacity (FVC), Best measure 0.1 0.5 1.2 0.5 0.2 -1.1
Body fat percentage 0.1 0.4 1.1 -0.3 1.0 -0.2
Leg fat percentage (right) 0.4 1.4 4.1 0.4 2.0 0.3
Arm fat-free mass (right) 0.8 3.9 10.2 0.7 1.1 -3.2
Exposure to tobacco smoke outside home 0.2 0.3 0.4 -0.6 -0.5 -0.6
Comparative body size at age 10 1.8 4.8 10.6 1.0 -1.7 -3.3
Number of full brothers 0.4 0.5 0.8 0.7 0.5 0.9
Worry too long after embarrassment 0.2 0.3 0.5 0.0 -0.7 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.9 -0.9 0.5 0.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.2 0.1 -0.7
Number of children fathered 0.1 0.2 0.2 -0.2 -0.4 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 2.9 3.3 4.6 -1.3 2.1 1.9
Age at first live birth 1.0 1.7 2.7 -1.6 -1.5 -0.5
Pulse wave peak to peak time 1.7 2.0 5.4 -2.3 -0.7 0.3
Health satisfaction 1.0 1.3 2.5 -1.2 -1.6 -0.2
Shortness of breath walking on level ground 0.7 0.9 2.1 -0.5 -1.5 -0.4
Qualifications: College or University degree 0.3 0.9 2.0 -0.5 -1.4 -0.8
Eye problems/disorders: None of the above 1.8 2.1 4.7 -2.2 -1.1 -0.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.4 -0.6 -1.2 -0.2
Emphysema/chronic bronchitis 1.2 1.4 2.0 -1.4 -0.9 -1.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.8 0.2 -0.2 -0.9
Neck or shoulder pain in last month 1.3 1.8 4.2 -2.0 0.6 1.0
Medication: Blood pressure 0.5 0.8 2.4 -1.5 -0.1 -0.1
Angina (self-reported) 0.4 0.5 1.3 -1.1 -0.4 -0.2
Migraine (self-reported) 0.1 0.1 0.1 0.3 0.3 0.1
Medication: Ibuprofen 0.8 0.9 2.2 -0.6 -1.5 0.5
Medication: Allopurinol 0.8 1.0 2.3 0.2 0.8 -1.5
Medication: Omeprazole 2.7 3.2 5.3 1.1 1.8 2.3
Medication: Seretide 50 evohaler 1.7 1.9 3.6 -0.5 -1.4 -1.9
Mean time to correctly identify matches 1.2 2.3 4.3 -2.1 -1.4 -0.6
Heart disease (mother) 1.5 1.9 2.9 0.4 1.6 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.1 0.9 0.4 1.1
Whole body fat mass 0.2 0.7 1.2 -0.4 0.7 -1.1
Leg fat mass (right) 0.2 1.0 2.2 -0.0 1.5 -0.8
Arm predicted mass (right) 0.6 3.3 8.6 0.2 1.1 -2.9
Pulse rate, automated reading 0.1 0.3 0.9 -0.1 1.0 0.2
Alcohol intake frequency. 4.1 9.5 18.3 4.3 2.7 -1.7
Comparative height size at age 10 1.1 6.1 9.6 -2.9 -3.1 -0.5
Number of full sisters 0.5 0.6 0.9 -0.3 0.9 0.9
Suffer from ‘nerves’ 0.1 0.2 0.6 0.1 0.7 0.1
Overall health rating 0.2 0.4 1.1 -1.1 -0.0 -0.4
Chest pain or discomfort 0.4 0.5 1.5 0.4 1.2 0.2
Had major operations 0.7 0.8 1.2 0.7 0.9 -1.1
Age at last live birth 1.9 2.7 4.0 -2.0 -1.8 -1.0
Family relationship satisfaction 2.4 2.9 6.5 -2.5 -1.5 -0.1
Leg pain on walking 0.4 0.5 0.7 0.5 0.8 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.7 0.8 0.9 -0.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.5 1.6 0.3 0.9
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 1.6 -1.3 -0.4 -1.0
Medication: Aspirin 0.2 0.2 0.3 -0.5 0.6 0.3
Supplements: Vitamin C 0.9 1.1 1.9 1.4 1.2 -0.0
Knee pain experienced in last month 0.8 1.2 3.0 -1.7 -0.4 0.7
Hypertension (Self-reported) 2.0 5.6 9.9 0.0 3.1 2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.7 -0.0 0.8 -0.0
Illnesses of father: Heart disease 0.2 0.3 0.5 -0.3 -0.4 -0.7
Illnesses of siblings: Diabetes 0.6 0.8 2.1 0.0 -0.5 -1.5
Smoking status: Previous 2.3 3.4 5.6 -2.4 -2.0 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.8 -1.3 0.1 -0.3
Whole body fat-free mass 0.4 2.6 7.5 -0.4 -0.2 -2.7
Leg fat-free mass (right) 0.3 1.5 4.5 -0.0 -0.1 -2.1
Arm fat percentage (left) 0.0 0.2 0.4 -0.3 0.6 -0.2
Average weekly red wine intake 3.3 4.9 6.6 -2.4 -1.5 -2.6
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.5 0.3 0.9 1.2
Mood swings 0.4 0.7 1.6 -0.1 -1.2 -0.7
Loneliness, isolation 1.5 2.0 5.1 -2.3 -0.9 -0.3
Long-standing illness, disability or infirmity 0.9 1.4 2.7 0.8 0.9 -1.6
Ever had bowel cancer screening 0.5 0.6 1.1 0.9 -0.1 1.1
Diabetes diagnosed by doctor 0.3 0.5 0.7 0.9 0.7 0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 6.7 -2.6 -0.9 1.1
Friendships satisfaction 0.8 1.0 2.7 -1.6 -0.7 0.1
Qualifications: nursing, teaching 1.7 2.7 5.8 0.7 -1.3 -2.4
Commuting to job workplace: Walk 1.2 1.2 2.6 0.8 0.7 -1.6
Eye problems/disorders: Cataract 1.2 1.4 2.1 1.0 1.4 1.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.8 0.6 -0.9 -0.4
Medication for cholesterol 3.2 4.9 7.3 -1.8 -2.7 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.5 -0.1 0.2
Back pain experienced in last month 0.1 0.2 0.3 -0.5 0.3 0.6
Mineral and other dietary supplements 1.6 2.2 3.7 -0.7 -1.5 1.9
Breast cancer (self-reported) 0.7 0.9 2.0 -0.8 -1.4 -0.2
Asthma (self-reported) 0.2 0.5 1.2 0.4 -0.0 1.1
Osteoporosis (self-reported) 1.1 1.3 2.2 1.3 1.5 0.2
Osteoarthritis (self-reported) 0.4 0.5 1.3 -0.2 1.1 0.3
Medication: Aspirin 0.4 0.5 1.0 -0.6 1.0 0.4
Medication: Gliclazide 0.6 0.7 1.1 1.1 1.0 0.2
Illnesses of father: None of the above (group 1) 0.2 0.3 0.5 0.7 0.1 -0.7
Smoking status: Current 1.2 1.9 4.0 -2.0 -1.3 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 2.8 1.7 1.0 -1.2
Whole body water mass 0.5 2.6 7.6 -0.5 -0.1 -2.8
Leg predicted mass (right) 0.3 1.5 4.5 -0.1 -0.0 -2.1
Arm fat mass (left) 0.1 0.6 1.4 -0.3 0.5 -1.2
Number of self-reported non-cancer illnesses 2.3 4.0 10.2 1.3 3.2 0.1
Average weekly champagne plus white wine intake 1.1 1.6 3.2 -0.4 -1.8 1.2
Miserableness 0.2 0.3 0.8 -0.1 0.9 0.4
Guilty feelings 0.2 0.2 0.4 -0.4 -0.7 0.4
Wears glasses or contact lenses 0.1 0.1 0.2 -0.1 -0.4 -0.0
Ever taken oral contraceptive pill 2.2 2.5 6.0 -0.9 -0.8 2.5
Hearing aid user 0.0 0.0 0.1 -0.1 -0.3 -0.2
Mother’s age at death 0.4 0.5 1.3 0.1 -1.2 -0.4
Financial situation satisfaction 0.2 0.2 0.3 0.3 0.5 -0.5
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.7 0.8 -0.2 -0.3
Commuting to job workplace: Public transport 1.2 1.4 3.8 -1.9 -0.3 -0.5
Eye problems/disorders: Glaucoma 2.0 2.4 6.1 0.7 2.5 0.7
Medication: Blood pressure 6.9 13.1 21.5 2.9 4.6 3.0
Pain type(s) experienced in last month: Hip pain 0.7 0.8 2.3 -1.5 0.3 -0.2
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.8 -0.2 1.2 -1.7
High cholesterol (Self-reported) 2.3 4.0 5.0 2.2 1.6 2.1
Medication: Bendroflumethiazide 4.2 6.4 10.3 2.9 3.2 0.7
Medication: Paracetamol 2.0 3.1 6.8 1.2 2.6 1.1
Medication: Lisinopril 0.3 0.4 0.6 -0.7 0.4 0.6
Medication: Atorvastatin 0.1 0.1 0.2 -0.1 0.5 -0.5
Illnesses of father: High blood pressure 0.8 1.0 2.8 0.3 1.7 0.2
Alcohol drinker status: Never 1.3 1.6 4.1 0.8 2.0 0.1
Ever smoked 2.0 3.5 5.0 -2.2 -2.2 -0.9
Basal metabolic rate 0.4 2.1 6.2 -0.4 0.1 -2.5
Leg fat percentage (left) 0.4 1.3 3.5 0.6 1.9 0.2
Arm fat-free mass (left) 0.5 2.7 8.0 -0.1 0.5 -2.8
Number of operations (self-reported) 0.7 1.0 1.4 0.7 1.2 -1.1
Average weekly beer plus cider intake 0.0 0.1 0.2 0.4 0.0 0.2
Irritability 0.9 1.6 2.8 -1.3 -1.7 -0.5
Risk taking 1.3 2.0 5.5 -0.6 -0.2 2.4
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 0.1 -0.8 -0.5
Fractured/broken bones in last 5 years 0.2 0.3 0.6 0.5 0.3 -0.8
Age started oral contraceptive pill 2.2 2.8 4.5 2.1 1.3 -1.4
Diastolic blood pressure, automated reading 2.0 6.2 15.2 0.3 3.9 1.8
Ever depressed for a whole week 0.7 0.9 1.6 -0.7 -0.8 -1.3
Unable to work because of sickness or disability 2.0 2.6 5.7 -2.4 -1.5 0.2
Commuting to job workplace: Cycle 0.6 0.7 2.2 1.5 -0.1 -0.1
Myopia 1.0 1.5 3.5 0.7 -1.9 0.6
Vascular/heart problems diagnosed by doctor 1.7 4.6 7.7 -0.1 -2.5 -2.8
Cholesterol lowering medication 3.6 5.3 8.2 2.9 2.4 1.4
Medication: Omeprazole (e.g. Zanprol) 4.7 5.7 8.5 1.7 2.9 2.4
Pain experienced in last month 0.3 0.4 1.0 1.0 0.5 0.2
Supplements: Calcium 0.7 0.8 1.2 1.1 1.0 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.5 -0.4 -0.4 1.2
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.3 -1.8 -1.0 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.6 0.6 1.2 -0.4
Heart disease (siblings) 0.8 0.9 1.1 -0.7 1.1 1.1
Alcohol drinker status: Previous 1.3 1.4 2.6 1.3 0.2 -1.6
Pack years of smoking 2.0 3.0 6.9 -0.1 1.5 2.6
Impedance of whole body 0.6 3.0 5.1 -1.7 -1.1 2.3
Leg fat mass (left) 0.2 0.9 2.1 0.0 1.4 -0.8
Arm predicted mass (left) 0.6 2.9 8.5 -0.4 0.2 -2.9