Hub : Genes

EIF4A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1120 0.0470 0.0078 0.003 NA 0.019 NA 0.008 0.1900 NA 0.01400 NA 0.0810
2 ROSMAP Brain Pre-frontal Cortex 0.0705 0.0312 0.0062 0.018 0.014 0.022 0.01 0.016 0.0017 0.0055 0.00064 0.018 0.0029

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.3 3.6 6.1 1.1 2.5
Bipolar Disorder or Schizophrenia 0.7 1.6 2.8 -0.6 1.7
Depressed Affect (Nagel 2018) 0.3 0.5 1.0 0.1 -1.0
Depression (Nagel 2018) 1.3 1.9 2.3 -1.3 -1.5
Intelligence (Savage-Jansen 2018) 1.0 3.0 4.3 2.1 1.3
Neuroticism (Nagel 2018) 0.2 0.5 0.6 0.7 -0.6
Schizophrenia (2018) 0.7 1.4 2.7 -1.6 0.2
Schizophrenia vs Biploar Disorder 1.4 1.8 2.7 -1.6 -1.0
Worry (Nagel 2018) 0.0 0.1 0.2 0.1 0.4
Alzheimer’s Disease (in mother) 2.1 2.5 2.7 -1.6 -1.5
Alzheimer’s Disease (in father) 1.0 1.1 2.2 0.1 -1.5
Alzheimer’s Disease (including proxy) 1.9 2.7 5.0 -0.7 -2.2
Crohns Disease (2017) 1.3 2.9 4.5 1.1 -2.1
Irritable Bowel Disease (IBD) 0.8 2.0 3.8 0.4 -2.0
Ulcerative Colitis (UC) 0.5 1.0 2.0 -0.2 -1.4
Major Depression (MDD) 1.5 1.8 2.2 -1.5 -1.2
Reaction Time 1.1 2.2 4.3 -0.2 -2.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.0 0.4 1.0
Breast Cancer 0.1 0.2 0.3 -0.5 0.5
Ovarian Cancer 0.4 0.6 0.9 1.0 -0.5
Prostate Cancer 1.4 2.0 2.2 -1.3 -1.5
Age at First Birth 1.4 2.0 4.0 0.0 2.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.1 1.5 2.7 -0.5 -1.6
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.0 1.6 3.3 1.8 -0.0
Mean Putamen Volume 0.4 0.4 0.8 0.3 0.9
Fasting Glucose 0.9 1.1 1.6 1.3 0.8
HbA1C 0.2 0.2 0.3 -0.5 0.4
HDL Cholesterol 1.6 2.6 5.0 -0.5 2.2
LDL Cholesterol 0.5 0.8 1.4 -0.3 -1.2
Lupus 0.3 0.4 0.7 0.3 -0.9
Neuroticism (2016) 0.3 0.5 0.9 -0.9 -0.2
Primary Biliary Cirrhosis 0.8 1.1 1.6 -0.8 1.3
Rheumatoid Arthritis 0.2 0.3 0.5 0.7 -0.4
Schizophrenia (2014) 0.4 1.0 1.0 -1.0 1.0
Triglycerides 0.3 0.5 1.1 -0.1 -1.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.3 0.6 -0.4
Ulcerative Colitis 0.1 0.1 0.1 0.3 -0.2
Blood Eosinophil Count 0.7 5.5 8.5 -2.9 -1.6
Blood Platelet Count 1.3 14.5 29.1 -0.1 -5.4
Blood Red Count 0.1 1.1 1.2 -1.0 1.1
Blood White Count 0.2 1.7 3.0 -0.6 -1.7
Heel T-Score 0.1 0.6 0.7 0.8 -0.7
BMI 1.5 8.7 10.5 -3.2 -2.6
Height 0.6 11.3 12.1 3.2 3.5
Waist Hip Ratio (WHR) 0.0 0.2 0.4 0.0 -0.6
Systolic Blood Pressure 2.5 12.3 13.7 -3.3 -3.7
Smoking Status 0.4 0.9 1.7 -0.2 1.3
Allergy or Eczema 0.5 1.3 2.4 0.4 -1.6
Cardiovascular Disease 2.1 7.0 10.2 -1.9 -3.2
Hypothyroidism (self reported) 0.2 0.4 0.7 0.8 -0.4
Respiratory disease 0.0 0.0 0.0 0.2 -0.1
Type 2 Diabetes (T2D) (2018) 2.0 3.8 6.5 -1.1 -2.5
Lung FEV1/FVC ratio 0.2 1.0 1.9 -0.3 -1.4
Lung FVC 0.3 1.3 2.6 -0.2 -1.6
Neuroticism 0.0 0.0 0.1 0.3 -0.0
Chronotype (morning person) 0.0 0.0 0.0 -0.1 0.2
Hair Pigment 0.0 0.7 0.8 0.8 0.9
Tanning 0.3 3.2 5.7 0.8 2.4
Hand grip strength (left) 1.6 4.3 4.8 1.9 2.2
Number of treatments/medications taken 1.0 1.8 2.4 -1.1 -1.6
Average weekly spirits intake 0.2 0.2 0.2 0.5 -0.4
Sensitivity / hurt feelings 0.3 0.6 1.1 1.1 0.2
Frequency of depressed mood in last 2 weeks 0.8 1.1 1.4 -0.9 -1.2
Hearing difficulty/problems: Yes 0.3 0.4 0.7 0.4 -0.9
Relative age of first facial hair 0.1 0.2 0.2 0.5 0.5
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.7 0.2 -1.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 -0.7 -0.2
Ever had hysterectomy (womb removed) 2.2 2.5 4.3 -2.1 -0.8
Systolic blood pressure, automated reading 3.0 8.8 11.0 -3.3 -2.6
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 3.0 1.3 -1.7
Angina 0.2 0.3 0.5 -0.3 0.7
Medication for hormone replacement therapy 0.3 0.4 0.6 0.3 0.8
Vitamin and mineral supplements 0.1 0.2 0.2 0.4 -0.4
Supplements: Zinc 0.3 0.3 0.6 -0.2 0.8
Medication: Co-codamol 0.1 0.1 0.1 -0.3 -0.3
Medication: Metformin 3.1 4.4 7.9 -0.9 -2.8
Diabetes (father) 0.7 0.9 1.7 -1.3 -0.2
Diabetes (mother) 1.1 1.4 2.7 0.1 -1.6
Severe depression (siblings) 0.1 0.1 0.3 -0.0 0.5
Pack years adult smoking proportion 0.1 0.2 0.3 0.6 0.1
Impedance of leg (right) 0.7 3.5 4.7 2.2 1.5
Leg fat-free mass (left) 0.3 1.4 2.7 -1.6 0.2
Trunk fat percentage 0.7 3.0 5.4 -2.3 -0.8
Hand grip strength (right) 2.4 6.5 7.2 2.4 2.7
Townsend deprivation index at recruitment 0.2 0.2 0.4 -0.6 0.2
Current tobacco smoking 2.6 4.3 7.5 2.7 1.1
Average weekly fortified wine intake 0.1 0.1 0.2 0.2 0.4
Maternal smoking around birth 0.1 0.1 0.2 0.4 0.2
Fed-up feelings 0.4 0.8 0.9 0.8 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 0.9 -1.0 -0.9
Relative age voice broke 0.6 1.0 1.9 -0.3 1.4
Taking other prescription medications 1.3 2.0 2.6 -1.6 -1.2
Age when periods started (menarche) 0.1 0.3 0.4 0.6 0.5
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 1.9 0.1 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.3 -0.5 0.1
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 0.8 -0.8 -0.9
Qualifications: CSEs or equivalent 0.1 0.1 0.2 0.2 -0.4
Serious illness, injury or assault to yourself 0.1 0.1 0.1 0.1 -0.3
High blood pressure 2.6 7.2 7.8 -2.6 -2.8
Hayfever, allergic rhinitis or eczema 1.1 2.5 5.0 0.0 -2.2
Multivitamins +/- minerals 1.7 2.2 2.6 -1.3 1.6
Stomach or abdominal pain in last month 0.5 0.6 0.7 0.8 0.7
Supplements: Glucosamine 0.5 0.7 1.4 -1.2 0.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 1.7 1.3 0.9
Medication: Atenolol 5.2 6.5 8.2 -2.9 -2.2
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.1 -0.4
Sitting height 0.1 0.4 0.8 0.9 -0.1
Chronic bronchitis/emphysema (father) 0.6 0.7 1.3 0.4 -1.1
High blood pressure (mother) 0.0 0.1 0.1 0.3 -0.1
Body mass index (BMI) 1.2 5.3 7.3 -2.7 -1.8
Impedance of leg (left) 1.0 5.0 6.6 2.6 1.9
Leg predicted mass (left) 0.2 1.3 2.5 -1.6 0.2
Trunk fat mass 0.7 2.9 5.5 -2.4 -0.5
Waist circumference 1.0 3.7 5.6 -2.4 -1.4
Number of incorrect matches in round 0.0 0.1 0.1 0.3 0.2
Past tobacco smoking 0.2 0.3 0.6 0.2 -0.8
Alcohol usually taken with meals 2.5 4.0 6.7 2.6 1.1
Nervous feelings 0.1 0.2 0.4 0.1 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.8 0.1 0.9
Hearing difficulty/problems with background noise 1.8 2.9 5.7 0.4 -2.4
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 0.4 -0.8
Had menopause 0.6 0.8 1.5 1.2 -0.2
Had other major operations 2.2 2.7 4.8 -2.2 -0.8
Forced vital capacity (FVC) 0.8 3.0 5.4 2.3 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 -0.6 0.1
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.1 -0.3 0.1
Qualifications: None of the above 0.9 2.0 2.3 -1.3 -1.5
Financial difficulties in last 2 years 1.4 1.9 2.0 -1.4 1.3
Mouth/teeth dental problems 1.5 2.3 2.6 -1.6 -1.4
Heart attack 2.1 2.7 3.9 1.2 2.0
Allergy 2.0 4.7 9.2 0.3 3.0
Pain all over the body in last month 1.1 1.2 1.4 -1.2 -1.0
Diabetes (self-reported) 2.8 4.4 7.4 -1.2 -2.7
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.3 0.1 -0.5
Medication: Ramipril 0.8 1.0 1.7 -1.3 -0.6
Medication: Simvastatin 0.7 1.1 1.8 -0.5 -1.4
Fluid intelligence score 0.2 0.3 0.4 0.5 0.7
Illnesses of siblings 3.6 5.0 5.1 2.3 2.2
Neuroticism score 0.1 0.2 0.4 0.2 0.6
Weight 0.3 1.6 3.1 -1.8 -0.3
Impedance of arm (right) 0.6 2.7 4.8 -0.8 2.2
Arm fat percentage (right) 1.8 7.1 13.2 -3.6 -1.0
Trunk fat-free mass 0.1 0.3 0.6 -0.2 0.8
Hip circumference 0.6 2.5 4.9 -2.2 0.1
Time employed in main current job 1.0 1.2 2.2 1.5 -0.4
Alcohol intake versus 10 years previously 1.1 1.6 3.1 -0.5 -1.8
Father’s age at death 0.1 0.1 0.2 -0.5 0.2
Worrier / anxious feelings 0.3 0.6 1.2 1.1 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.8 -0.9 -0.3
Falls in the last year 0.1 0.2 0.3 -0.2 0.5
Hair/balding pattern: Pattern 3 0.9 1.4 2.6 0.4 -1.6
Number of live births 0.2 0.3 0.6 0.1 -0.8
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 4.7 2.2 0.6
Pulse rate 0.8 1.3 2.5 1.6 -0.3
Happiness 2.7 3.2 3.6 -1.9 -1.7
Noisy workplace 2.8 3.4 6.6 -0.6 -2.6
Qualifications: A levels/AS levels or equivalent 1.4 3.1 3.7 1.9 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.1 -0.6
Mouth/teeth dental problems: Dentures 1.7 2.9 3.1 1.6 1.7
Asthma 0.2 0.4 0.7 -0.2 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 1.3 1.0 -1.1
Medication: Cholesterol lowering 0.0 0.0 0.1 0.1 0.2
Depression (self-reported) 0.3 0.4 0.4 -0.6 0.6
Medication: Lansoprazole 0.1 0.1 0.2 -0.2 -0.4
Prospective memory result 0.1 0.1 0.1 0.3 0.2
Lung cancer (father) 1.5 1.8 3.1 -0.7 1.8
Illnesses of mother 0.5 0.6 0.9 0.6 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 5.7 2.4 0.2
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 0.7 -0.2
Impedance of arm (left) 0.5 2.1 4.0 -0.5 2.0
Arm fat mass (right) 1.4 5.8 10.4 -3.2 -1.1
Trunk predicted mass 0.1 0.3 0.6 -0.1 0.8
Standing height 0.8 8.0 10.7 2.3 3.3
Length of working week for main job 1.5 1.7 2.2 1.1 1.5
Exposure to tobacco smoke at home 0.3 0.3 0.5 -0.7 0.4
Breastfed as a baby 1.9 2.3 2.5 -1.6 -1.4
Tense / ‘highly strung’ 0.4 0.7 1.3 -1.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 1.3 -1.1 -1.1
Hair/balding pattern: Pattern 4 0.9 2.3 2.5 1.6 1.4
Birth weight of first child 0.2 0.4 0.4 -0.6 0.6
Peak expiratory flow (PEF) 1.8 4.1 7.0 2.6 1.1
Pulse wave reflection index 1.4 1.7 3.4 0.2 1.9
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.4 -0.6 0.4
Loud music exposure frequency 1.2 1.3 2.5 -0.3 1.6
Qualifications: O levels/GCSEs or equivalent 1.7 2.7 3.9 1.2 2.0
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 -0.9 -0.3
Blood clot in the leg (DVT) 2.3 3.0 5.9 -0.2 -2.4
Medication: Paracetamol 0.5 0.8 1.5 1.2 -0.5
Headache pain in last month 1.0 1.8 3.0 1.7 -0.8
Medication for cholesterol, blood pressure or diabetes 2.4 4.0 4.8 2.2 1.8
Glaucoma (self-reported) 0.9 1.0 2.1 -1.4 -0.1
Gout (self-reported) 0.3 0.4 0.6 -0.3 -0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 0.3 -1.0
Medication: Amlodipine 5.4 7.6 10.8 -2.1 -3.3
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 -0.2 -0.4
Birth weight 1.8 3.9 4.5 -1.8 2.1
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.3 -1.1 -0.6
High blood pressure (siblings) 1.8 2.6 4.0 -1.1 -2.0
Forced vital capacity (FVC), Best measure 0.9 3.4 6.5 2.5 0.5
Body fat percentage 0.8 3.2 5.9 -2.4 -0.8
Leg fat percentage (right) 0.9 3.2 4.7 -2.2 -1.3
Arm fat-free mass (right) 0.0 0.0 0.0 -0.0 -0.1
Exposure to tobacco smoke outside home 0.0 0.1 0.1 0.2 -0.3
Comparative body size at age 10 0.6 1.7 3.4 -0.1 1.8
Number of full brothers 0.0 0.0 0.0 -0.2 -0.2
Worry too long after embarrassment 0.8 1.3 1.8 1.4 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.4 0.6 0.6
Wheeze or whistling in the chest in last year 0.1 0.2 0.2 -0.4 -0.3
Number of children fathered 0.4 0.5 1.0 1.0 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.0 -0.5
Age at first live birth 0.6 1.0 2.1 -0.0 1.4
Pulse wave peak to peak time 0.2 0.2 0.2 -0.4 0.5
Health satisfaction 0.6 0.7 1.1 -1.1 -0.6
Shortness of breath walking on level ground 0.1 0.1 0.1 -0.3 -0.4
Qualifications: College or University degree 0.8 2.6 3.7 1.2 1.9
Eye problems/disorders: None of the above 1.5 1.7 3.4 -0.3 1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 -0.8 0.2
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.2 0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 0.3 0.6
Neck or shoulder pain in last month 0.6 0.9 1.5 1.2 -0.6
Medication: Blood pressure 4.3 7.6 10.5 -3.2 -2.2
Angina (self-reported) 0.2 0.3 0.5 -0.2 0.7
Migraine (self-reported) 0.2 0.3 0.6 0.2 0.8
Medication: Ibuprofen 1.5 1.8 3.1 0.7 -1.8
Medication: Allopurinol 1.0 1.3 2.1 -0.7 -1.4
Medication: Omeprazole 0.7 0.8 1.5 -0.3 1.2
Medication: Seretide 50 evohaler 1.3 1.5 2.9 -1.7 0.4
Mean time to correctly identify matches 1.8 3.4 6.9 0.0 -2.6
Heart disease (mother) 0.1 0.1 0.2 0.3 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.0 0.6 1.0
Whole body fat mass 0.6 2.5 4.8 -2.2 -0.4
Leg fat mass (right) 0.5 2.0 3.5 -1.9 -0.7
Arm predicted mass (right) 0.0 0.0 0.0 0.1 -0.1
Pulse rate, automated reading 0.8 2.5 4.0 2.0 1.0
Alcohol intake frequency. 2.0 4.6 7.7 -1.2 -2.8
Comparative height size at age 10 0.1 0.6 1.0 1.0 0.4
Number of full sisters 0.4 0.5 0.6 -0.8 0.6
Suffer from ‘nerves’ 1.1 1.7 3.4 -0.2 1.9
Overall health rating 1.3 2.7 3.3 -1.5 -1.8
Chest pain or discomfort 0.1 0.1 0.2 0.1 0.5
Had major operations 0.9 1.0 2.0 -1.4 0.3
Age at last live birth 0.3 0.4 0.5 0.7 0.6
Family relationship satisfaction 0.0 0.1 0.1 -0.3 -0.2
Leg pain on walking 4.2 5.3 6.6 -2.0 -2.6
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 2.9 -1.7 1.0
Commuting to job workplace: Car/motor vehicle 0.1 0.2 0.3 0.3 0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 0.7 0.8 -0.6
Medication: Aspirin 2.4 3.1 5.4 -2.3 0.9
Supplements: Vitamin C 0.2 0.3 0.6 0.8 0.1
Knee pain experienced in last month 0.9 1.4 2.6 -0.4 -1.6
Hypertension (Self-reported) 3.4 9.4 12.2 -2.6 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.7 0.5 0.8
Illnesses of father: Heart disease 0.1 0.1 0.2 0.2 0.5
Illnesses of siblings: Diabetes 4.2 5.1 8.3 -2.9 -1.4
Smoking status: Previous 1.0 1.5 2.2 -1.5 0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.6 8.6 0.8 2.9
Whole body fat-free mass 0.1 0.3 0.4 -0.6 0.5
Leg fat-free mass (right) 0.2 1.1 2.1 -1.5 0.4
Arm fat percentage (left) 1.9 7.7 14.1 -3.8 -1.2
Average weekly red wine intake 2.4 3.6 5.3 2.3 1.4
Handedness (chirality/laterality): Left-handed 1.5 1.8 2.7 -1.6 0.9
Mood swings 0.1 0.1 0.2 0.4 -0.0
Loneliness, isolation 0.2 0.2 0.3 -0.4 0.5
Long-standing illness, disability or infirmity 4.1 6.3 10.2 -1.5 -3.2
Ever had bowel cancer screening 0.4 0.5 0.9 0.3 -0.9
Diabetes diagnosed by doctor 2.5 4.2 8.0 -0.6 -2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.9 1.0 0.2
Friendships satisfaction 0.2 0.2 0.4 -0.6 0.3
Qualifications: nursing, teaching 3.1 4.8 6.8 1.7 2.6
Commuting to job workplace: Walk 1.1 1.2 2.3 0.1 1.5
Eye problems/disorders: Cataract 1.4 1.6 2.7 1.7 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 3.7 1.9 -0.8
Medication for cholesterol 2.3 3.5 5.6 1.2 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.7 0.2 -0.8
Back pain experienced in last month 4.3 6.2 11.6 0.9 -3.4
Mineral and other dietary supplements 0.1 0.2 0.3 0.6 -0.1
Breast cancer (self-reported) 1.6 2.0 2.2 1.3 1.5
Asthma (self-reported) 0.3 0.6 1.1 -0.2 -1.1
Osteoporosis (self-reported) 1.3 1.6 3.1 -0.2 1.8
Osteoarthritis (self-reported) 4.1 5.3 9.0 -1.3 -3.0
Medication: Aspirin 1.7 2.2 3.3 -1.8 1.1
Medication: Gliclazide 2.4 2.7 4.5 -1.0 -2.1
Illnesses of father: None of the above (group 1) 0.5 0.6 0.7 0.7 0.8
Smoking status: Current 2.3 3.7 6.3 2.5 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 2.6 -0.8 -1.6
Whole body water mass 0.1 0.3 0.4 -0.6 0.5
Leg predicted mass (right) 0.2 1.1 2.1 -1.4 0.4
Arm fat mass (left) 1.2 4.8 8.5 -2.9 -1.1
Number of self-reported non-cancer illnesses 1.2 2.0 3.3 -0.8 -1.8
Average weekly champagne plus white wine intake 0.3 0.5 0.6 0.6 0.8
Miserableness 0.2 0.4 0.7 -0.8 -0.3
Guilty feelings 0.4 0.6 1.0 -1.0 -0.3
Wears glasses or contact lenses 1.4 1.6 3.2 1.8 -0.2
Ever taken oral contraceptive pill 1.3 1.5 2.1 -1.5 -0.9
Hearing aid user 0.9 1.1 1.7 -0.7 1.3
Mother’s age at death 0.6 0.7 1.3 -1.1 -0.4
Financial situation satisfaction 1.2 1.5 1.5 -1.2 1.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.3 -0.4
Commuting to job workplace: Public transport 5.0 5.9 8.3 2.9 1.9
Eye problems/disorders: Glaucoma 0.1 0.2 0.2 -0.3 -0.5
Medication: Blood pressure 7.3 13.8 22.8 -2.2 -4.8
Pain type(s) experienced in last month: Hip pain 0.8 0.9 1.6 0.6 -1.3
Supplements: Fish oil (including cod liver oil) 0.9 1.2 1.9 -0.7 -1.4
High cholesterol (Self-reported) 0.2 0.3 0.3 0.6 -0.6
Medication: Bendroflumethiazide 5.2 7.9 9.2 -2.6 -3.0
Medication: Paracetamol 0.7 1.0 1.8 1.4 0.5
Medication: Lisinopril 1.6 2.0 3.3 -1.8 -0.9
Medication: Atorvastatin 1.0 1.2 1.8 1.4 -0.8
Illnesses of father: High blood pressure 3.6 4.5 8.1 -2.9 -0.9
Alcohol drinker status: Never 0.1 0.1 0.3 -0.0 -0.5
Ever smoked 0.2 0.3 0.4 0.6 0.5
Basal metabolic rate 0.1 0.6 0.9 -1.0 0.5
Leg fat percentage (left) 0.8 2.7 3.9 -2.0 -1.2
Arm fat-free mass (left) 0.0 0.1 0.1 0.2 -0.3
Number of operations (self-reported) 0.5 0.7 0.8 -0.9 -0.7
Average weekly beer plus cider intake 2.0 2.9 5.8 -2.4 0.2
Irritability 0.7 1.3 1.9 0.8 1.4
Risk taking 0.6 0.9 1.0 0.9 -1.0
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 0.7 -0.0
Fractured/broken bones in last 5 years 0.0 0.0 0.0 0.2 -0.1
Age started oral contraceptive pill 1.6 2.0 2.4 -1.3 -1.5
Diastolic blood pressure, automated reading 1.7 5.4 9.1 -3.0 -1.3
Ever depressed for a whole week 0.8 0.9 1.6 -1.3 -0.5
Unable to work because of sickness or disability 0.3 0.4 0.7 0.9 0.2
Commuting to job workplace: Cycle 0.5 0.6 0.8 -0.6 -0.9
Myopia 0.6 0.9 1.1 0.8 1.1
Vascular/heart problems diagnosed by doctor 1.9 5.1 5.8 2.4 2.1
Cholesterol lowering medication 0.3 0.5 0.9 0.1 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.0 -0.3 1.4
Pain experienced in last month 0.4 0.8 1.5 -0.1 1.2
Supplements: Calcium 2.5 2.8 4.1 1.2 2.0
Basal cell carcinoma (self-reported) 8.0 9.5 18.1 -0.9 -4.3
Heart attack/myocardial infarction (self-reported) 2.0 2.6 3.3 1.4 1.8
Deep venous thrombosis (DVT) (self-reported) 2.7 3.5 6.8 -0.4 -2.6
Heart disease (siblings) 0.7 0.9 1.6 -1.2 -0.5
Alcohol drinker status: Previous 0.2 0.3 0.4 -0.4 -0.6
Pack years of smoking 0.1 0.2 0.4 0.6 -0.2
Impedance of whole body 0.5 2.4 3.0 1.4 1.7
Leg fat mass (left) 0.5 2.1 3.8 -2.0 -0.6
Arm predicted mass (left) 0.0 0.0 0.1 -0.2 -0.2