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chr2:26,592,429-29,344,127

Best TWAS P=2.72e-25 · Best GWAS P=2.25e-46 conditioned to 3.73e-17

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C2orf16	0.03	0.00	lasso	5	0.02	3.3e-03	-4.46	6.3	3.1e-10	-0.08	0.14	0.14	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	-7.03	7.5	7.2e-14	-0.12	0.19	0.81	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	-7.98	-8.6	9.7e-18	0.11	0.06	0.94	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PPM1G	0.03	0.01	bslmm	305	0.00	8.7e-02	-8.09	-7.1	1.4e-12	0.12	0.05	0.92	FALSE
5	GTEx	Adipose Subcutaneous	NRBP1	0.07	0.04	lasso	5	0.05	6.9e-05	-7.96	7.7	2.1e-14	-0.11	0.48	0.49	FALSE
6	GTEx	Adipose Subcutaneous	PPM1G	0.04	0.05	lasso	2	0.04	4.9e-04	-7.91	7.9	2.1e-15	-0.11	0.28	0.55	FALSE
7	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	-9.00	8.4	4.0e-17	-0.11	0.01	0.99	FALSE
8	GTEx	Adipose Visceral Omentum	NRBP1	0.05	0.05	lasso	4	0.04	2.5e-03	-7.91	8.0	1.4e-15	-0.12	0.19	0.48	FALSE
9	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	-7.91	8.5	2.1e-17	-0.11	0.03	0.81	FALSE
10	GTEx	Adipose Visceral Omentum	KRTCAP3	0.10	0.07	lasso	4	0.06	5.2e-04	-7.03	-7.1	1.4e-12	0.12	0.36	0.52	FALSE
11	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	-7.85	7.8	5.4e-15	-0.13	0.43	0.53	FALSE
12	GTEx	Adrenal Gland	KRTCAP3	0.11	0.16	lasso	4	0.15	4.9e-06	-8.10	-8.1	6.1e-16	0.11	0.09	0.90	FALSE
13	GTEx	Artery Aorta	NRBP1	0.06	0.07	enet	8	0.06	2.6e-04	-7.45	7.5	9.2e-14	-0.11	0.04	0.92	FALSE
14	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	-7.85	7.8	5.2e-15	-0.13	0.09	0.67	FALSE
15	GTEx	Artery Aorta	RP11-373D23.3	0.23	0.12	enet	12	0.06	2.5e-04	-13.20	10.4	2.7e-25	-0.80	0.14	0.79	TRUE
16	GTEx	Artery Coronary	NRBP1	0.09	0.01	enet	14	0.03	4.4e-02	-4.51	6.4	1.7e-10	-0.09	0.14	0.46	FALSE
17	GTEx	Artery Coronary	AC074117.10	0.13	0.17	enet	9	0.12	5.4e-05	-5.05	5.8	8.5e-09	-0.06	0.11	0.72	FALSE
18	GTEx	Artery Tibial	NRBP1	0.07	0.03	lasso	11	0.05	1.3e-04	-7.87	7.4	1.6e-13	-0.13	0.02	0.96	FALSE
19	GTEx	Artery Tibial	SNX17	0.11	0.07	enet	31	0.04	3.3e-04	-7.87	7.2	7.6e-13	-0.11	0.72	0.26	FALSE
20	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	-7.01	7.6	3.4e-14	-0.12	0.17	0.48	FALSE
21	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	-7.85	8.5	2.6e-17	-0.12	0.03	0.97	FALSE
22	GTEx	Brain Caudate basal ganglia	RP11-373D23.2	0.25	-0.01	lasso	6	0.00	3.6e-01	-0.24	-6.4	1.2e-10	0.50	0.05	0.33	FALSE
23	GTEx	Brain Cerebellum	AC074117.10	0.13	0.08	enet	6	0.07	4.4e-03	-7.95	-8.1	6.3e-16	0.12	0.03	0.82	FALSE
24	GTEx	Brain Cortex	KRTCAP3	0.19	0.10	lasso	2	0.12	3.7e-04	-7.81	-7.4	1.0e-13	0.13	0.26	0.30	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	-8.10	8.4	6.3e-17	-0.10	0.03	0.95	FALSE
26	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	-7.85	7.6	2.1e-14	-0.13	0.17	0.83	FALSE
27	GTEx	Cells Transformed fibroblasts	PPM1G	0.06	0.00	lasso	4	0.01	3.2e-02	-7.99	7.2	5.9e-13	-0.07	0.02	0.91	FALSE
28	GTEx	Cells Transformed fibroblasts	IFT172	0.04	0.04	lasso	2	0.02	8.1e-03	-7.85	-8.0	1.6e-15	0.11	0.17	0.36	FALSE
29	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	-9.00	9.1	6.9e-20	-0.09	0.00	1.00	TRUE
30	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	-7.85	7.8	5.9e-15	-0.13	0.07	0.92	FALSE
31	GTEx	Colon Transverse	NRBP1	0.08	0.03	enet	14	0.00	2.0e-01	-7.45	7.5	4.3e-14	-0.12	0.04	0.80	FALSE
32	GTEx	Colon Transverse	AC074117.10	0.13	0.13	enet	16	0.14	2.3e-07	-7.03	7.1	1.2e-12	-0.14	0.09	0.90	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	NRBP1	0.11	0.01	enet	23	0.02	7.7e-02	-5.11	6.7	1.7e-11	-0.13	0.04	0.74	FALSE
34	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	-7.91	7.4	1.6e-13	-0.13	0.03	0.95	FALSE
35	GTEx	Esophagus Gastroesophageal Junction	RP11-373D23.3	0.17	0.01	enet	15	0.04	1.2e-02	-14.30	6.5	9.7e-11	-0.64	0.02	0.80	FALSE
36	GTEx	Esophagus Mucosa	NRBP1	0.13	0.06	enet	13	0.06	4.1e-05	-9.00	8.0	1.8e-15	-0.09	0.01	0.99	FALSE
37	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	-9.00	8.6	7.0e-18	-0.08	0.01	0.99	FALSE
38	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	-9.00	8.4	3.1e-17	-0.10	0.00	0.99	FALSE
39	GTEx	Esophagus Muscularis	PPM1G	0.06	0.10	lasso	2	0.07	3.7e-05	-8.09	8.1	5.3e-16	-0.11	0.11	0.86	FALSE
40	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	-9.00	8.7	4.5e-18	-0.11	0.00	1.00	FALSE
41	GTEx	Lung	NRBP1	0.05	0.05	enet	9	0.05	1.7e-04	-7.01	7.5	5.0e-14	-0.14	0.07	0.92	FALSE
42	GTEx	Lung	AC074117.10	0.07	0.06	lasso	6	0.05	6.6e-05	-7.01	7.7	1.3e-14	-0.13	0.16	0.84	FALSE
43	GTEx	Muscle Skeletal	SNX17	0.18	0.24	lasso	6	0.26	6.2e-26	-7.91	8.0	9.7e-16	-0.13	0.90	0.10	FALSE
44	GTEx	Muscle Skeletal	KRTCAP3	0.08	0.06	lasso	4	0.04	3.1e-05	-8.09	-8.0	1.1e-15	0.11	0.82	0.18	FALSE
45	GTEx	Muscle Skeletal	SLC4A1AP	0.04	0.02	lasso	4	0.01	1.5e-02	6.59	-6.0	1.7e-09	0.07	0.17	0.03	FALSE
46	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	5.73	5.4	5.5e-08	-0.07	0.28	0.07	FALSE
47	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	-9.00	7.2	4.6e-13	-0.11	0.01	0.99	FALSE
48	GTEx	Nerve Tibial	PPM1G	0.09	0.06	lasso	4	0.05	1.2e-04	-6.77	6.8	8.5e-12	-0.13	0.06	0.92	FALSE
49	GTEx	Nerve Tibial	SLC5A6	0.16	0.16	lasso	8	0.16	4.3e-11	-5.00	5.2	1.5e-07	-0.09	1.00	0.00	FALSE
50	GTEx	Nerve Tibial	AC074117.10	0.04	0.05	lasso	2	0.04	7.7e-04	-7.85	7.8	6.5e-15	-0.12	0.17	0.48	FALSE
51	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	-7.91	8.1	6.5e-16	-0.10	0.07	0.65	FALSE
52	GTEx	Pituitary	AC074117.10	0.23	0.23	lasso	8	0.29	5.6e-08	-6.77	7.5	7.1e-14	-0.13	0.17	0.79	FALSE
53	GTEx	Prostate	AC074117.10	0.14	0.01	lasso	5	0.02	8.8e-02	-9.00	8.6	7.5e-18	-0.10	0.02	0.84	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	NRBP1	0.19	0.15	lasso	7	0.16	6.0e-09	-7.01	7.5	6.6e-14	-0.12	0.11	0.89	FALSE
55	GTEx	Skin Sun Exposed Lower leg	NRBP1	0.10	0.08	lasso	6	0.08	3.6e-07	-7.91	8.7	2.9e-18	-0.11	0.02	0.98	FALSE
56	GTEx	Skin Sun Exposed Lower leg	ATRAID	0.14	0.07	enet	15	0.09	1.3e-07	-4.74	-5.3	9.9e-08	0.10	0.96	0.03	FALSE
57	GTEx	Skin Sun Exposed Lower leg	SLC4A1AP	0.04	0.01	lasso	3	0.02	1.7e-02	-8.09	-7.7	1.2e-14	0.10	0.19	0.22	FALSE
58	GTEx	Spleen	FNDC4	0.41	0.27	lasso	7	0.24	1.0e-06	5.65	-6.0	2.0e-09	0.08	0.93	0.04	FALSE
59	GTEx	Spleen	IFT172	0.17	0.13	lasso	3	0.07	7.8e-03	4.47	-5.2	2.2e-07	0.06	0.15	0.09	FALSE
60	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	-9.00	8.9	7.3e-19	-0.10	0.00	0.99	FALSE
61	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	-8.02	8.1	5.7e-16	-0.10	0.34	0.65	FALSE
62	GTEx	Testis	RP11-195B17.1	0.13	0.00	lasso	4	0.02	4.5e-02	-7.01	6.5	8.9e-11	-0.07	0.05	0.07	FALSE
63	GTEx	Thyroid	CAD	0.07	0.01	enet	15	0.02	6.1e-03	-7.85	7.4	1.3e-13	-0.10	0.45	0.38	FALSE
64	GTEx	Thyroid	NRBP1	0.08	0.07	enet	29	0.04	3.7e-04	-7.81	6.0	1.7e-09	-0.12	0.06	0.93	FALSE
65	GTEx	Thyroid	PPM1G	0.06	0.06	lasso	3	0.06	2.2e-05	-7.91	8.0	9.7e-16	-0.12	0.51	0.45	FALSE
66	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	-7.91	7.8	8.8e-15	-0.13	0.51	0.49	FALSE
67	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	-13.19	8.3	1.0e-16	-0.65	0.08	0.86	FALSE
68	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	-7.81	7.9	2.6e-15	-0.09	0.07	0.61	FALSE
69	GTEx	Whole Blood	NRBP1	0.06	0.00	enet	11	0.00	2.3e-01	-4.74	9.1	7.9e-20	-0.08	0.02	0.67	TRUE
70	GTEx	Whole Blood	KRTCAP3	0.12	0.05	enet	10	0.05	9.9e-06	-7.96	-6.5	6.4e-11	0.09	0.67	0.32	FALSE
71	METSIM	Adipose	ATRAID	0.11	0.09	bslmm	297	0.10	1.4e-14	-5.02	-5.4	5.6e-08	0.09	1.00	0.00	FALSE
72	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	-7.96	-6.3	2.8e-10	0.11	0.78	0.21	FALSE
73	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	-9.00	8.9	4.5e-19	-0.10	0.00	1.00	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	SNX17	0.27	0.35	lasso	10	0.34	7.9e-46	-7.85	-7.9	3.7e-15	0.12	0.93	0.07	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	PPM1G	0.02	0.02	lasso	2	0.01	5.2e-03	5.82	5.8	6.1e-09	-0.06	0.46	0.19	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	-7.85	-7.7	1.1e-14	0.12	0.16	0.81	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	KRTCAP3	0.06	0.05	blup	279	0.05	3.1e-07	-7.91	-5.6	1.7e-08	0.11	0.91	0.09	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	ZNF513	0.04	0.05	blup	280	0.05	1.3e-06	-8.10	7.0	2.3e-12	-0.11	0.88	0.12	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	-9.00	7.8	7.2e-15	-0.09	0.01	0.92	FALSE
80	YFS	Blood	KRTCAP3	0.12	0.18	bslmm	286	0.18	1.0e-55	-7.99	-7.1	9.2e-13	0.10	0.90	0.10	FALSE
81	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	-8.02	8.2	3.4e-16	-0.12	0.04	0.96	FALSE
82	YFS	Blood	SNX17	0.05	0.03	blup	288	0.04	1.0e-11	-7.85	5.5	3.0e-08	-0.12	0.19	0.81	FALSE
83	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C2orf16	0.05	0.03	lasso	2	0.03	2.2e-03	5.77	5.8	8.2e-09	-0.07	0.01	0.79	FALSE
84	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBP1	0.05	0.06	lasso	2	0.05	6.0e-05	-7.80	7.8	6.3e-15	-0.12	0.26	0.69	FALSE
85	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	-7.95	8.2	1.7e-16	-0.11	0.02	0.76	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	4.85	5.8	6.5e-09	-0.08	0.03	0.87	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	KRTCAP3	0.01	0.00	blup	27	0.00	8.7e-02	-7.81	-7.8	4.0e-15	0.11	0.03	0.52	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBP1	0.03	0.03	blup	29	0.03	1.2e-06	-7.85	8.2	3.1e-16	-0.12	0.27	0.73	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	-2.78	-6.6	3.8e-11	0.05	0.00	0.92	FALSE
90	The Cancer Genome Atlas	Colon Adenocarcinoma	NRBP1	0.03	0.04	lasso	1	0.03	5.2e-03	-8.09	8.1	5.9e-16	-0.10	0.02	0.65	FALSE
91	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	-9.00	9.0	2.4e-19	-0.09	0.00	0.81	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	43	0.02	2.7e-03	-7.85	8.0	1.3e-15	-0.12	0.04	0.66	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC4A1AP	0.02	0.03	lasso	2	0.03	3.7e-04	5.94	-6.2	6.2e-10	0.08	0.01	0.84	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KRTCAP3	0.02	0.01	blup	28	0.01	2.9e-02	-7.99	-7.8	4.2e-15	0.11	0.03	0.63	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBP1	0.06	0.07	lasso	2	0.07	1.1e-08	-7.96	8.0	1.8e-15	-0.10	0.24	0.76	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX17	0.02	0.01	blup	26	0.01	2.1e-02	-7.81	-8.1	4.3e-16	0.12	0.03	0.83	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPN1	0.03	0.04	enet	2	0.04	1.1e-05	5.94	5.9	2.8e-09	-0.06	0.00	0.99	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPM1G	0.03	0.03	blup	32	0.02	9.3e-04	-7.81	7.6	2.8e-14	-0.11	0.28	0.27	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBP1	0.03	0.05	blup	30	0.05	3.7e-06	-7.96	7.8	6.9e-15	-0.11	0.18	0.82	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	44	0.01	1.4e-02	-7.81	7.6	2.2e-14	-0.10	0.05	0.22	FALSE
101	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C2orf28	0.07	0.03	lasso	3	0.06	2.8e-03	-4.74	-5.2	2.1e-07	0.08	0.02	0.63	FALSE
102	The Cancer Genome Atlas	Prostate Adenocarcinoma	C2orf28	0.16	0.11	lasso	7	0.15	2.5e-15	-4.65	-5.4	6.2e-08	0.08	0.03	0.96	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	-7.81	8.4	4.3e-17	-0.12	0.03	0.96	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1G	0.03	0.02	blup	32	0.02	2.4e-03	-7.08	7.9	3.9e-15	-0.13	0.02	0.89	FALSE
105	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SLC4A1AP	0.17	0.05	blup	26	0.08	4.4e-03	4.85	-5.9	3.6e-09	0.07	0.01	0.67	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	KRTCAP3	0.04	0.04	lasso	1	0.03	3.4e-04	-7.81	-7.8	5.9e-15	0.12	0.10	0.21	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	-9.00	8.4	3.2e-17	-0.12	0.01	0.96	FALSE