Hub : Genes

SLC7A6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0890	0.0430	1.3e-03	-0.004	NA	0.005	NA	0.001	9.1e-01	NA	1.4e-01	NA	2.7e-01
2	GTEx	Lung	0.0751	0.0296	3.0e-05	0.088	NA	0.063	NA	0.076	2.8e-07	NA	1.3e-05	NA	1.9e-06
3	GTEx	Small Intestine Terminal Ileum	0.4100	0.1550	2.1e-04	0.162	NA	0.193	NA	0.205	1.9e-04	NA	4.2e-05	NA	2.3e-05
4	GTEx	Thyroid	0.1680	0.0440	5.9e-14	0.258	NA	0.251	NA	0.262	8.6e-20	NA	3.1e-19	NA	4.0e-20
5	NTR	Blood	0.0290	0.0100	1.8e-09	0.034	0.029	0.031	0.028	0.033	3.8e-11	1.1e-09	2.3e-10	1.4e-09	5.9e-11
6	YFS	Blood	0.2019	0.0402	0.0e+00	0.251	0.237	0.259	0.255	0.263	1.4e-81	2.6e-76	1.8e-84	4.4e-83	6.1e-86
7	TCGA	Colon Adenocarcinoma	0.0490	0.0350	6.4e-03	0.035	0.012	0.022	NA	0.019	3.9e-03	6.0e-02	2.0e-02	NA	2.6e-02
8	TCGA	Brain Lower Grade Glioma	0.0486	0.0279	9.0e-06	0.048	0.053	0.032	NA	0.053	3.3e-06	1.0e-06	1.5e-04	NA	1.1e-06
9	TCGA	Testicular Germ Cell Tumors	0.0880	0.0570	4.9e-03	0.099	0.073	0.085	NA	0.088	2.4e-04	1.4e-03	6.5e-04	NA	4.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	3.3	5.2	8.8	-1.1	-2.6	-3.0	1.6	-2.1	-2.5	-2.8	-2.5	-1.5
Bipolar Disorder or Schizophrenia	2.8	6.9	13.4	-0.9	-3.7	-3.3	1.4	-2.5	-2.8	-3.3	-2.9	-1.3
Depressed Affect (Nagel 2018)	0.7	1.4	2.3	0.8	1.0	1.2	-1.2	0.9	1.5	1.4	1.4	1.2
Depression (Nagel 2018)	0.9	1.4	3.0	1.0	0.7	1.1	-1.3	0.7	1.7	1.2	1.2	1.3
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	-1.0	1.1	-0.6	0.9	-0.6	-0.6	-0.7	-0.8	-0.8
Neuroticism (Nagel 2018)	1.2	2.7	4.2	1.1	1.0	1.4	-1.9	1.4	1.9	1.8	1.8	2.0
Schizophrenia (2018)	1.2	2.6	6.8	-0.3	-2.6	-2.0	0.6	-1.5	-1.5	-2.0	-1.7	-0.5
Schizophrenia vs Biploar Disorder	2.4	3.2	5.9	-2.4	-2.1	-1.4	1.6	-2.2	-1.4	-1.7	-1.6	-1.5
Worry (Nagel 2018)	1.2	2.6	5.0	1.1	1.2	1.0	-2.1	1.3	1.8	1.6	1.7	2.2
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	0.7	-0.2	-0.1	0.5	0.3	0.0	0.2	0.0	-0.6
Alzheimer’s Disease (in father)	0.3	0.3	0.9	-0.3	0.1	0.6	-0.9	0.2	0.2	0.4	0.6	0.9
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	0.7	0.3	0.7	-0.3	0.8	0.5	0.7	0.8	0.2
Crohns Disease (2017)	0.1	0.1	0.4	-0.3	0.5	0.1	0.1	0.6	0.0	0.3	0.4	-0.0
Irritable Bowel Disease (IBD)	0.9	2.2	6.1	2.0	1.3	1.0	-0.8	2.5	1.3	1.3	1.4	0.9
Ulcerative Colitis (UC)	1.2	2.2	8.4	2.9	0.8	0.7	-0.7	2.4	1.2	1.0	1.0	0.8
Major Depression (MDD)	2.7	3.3	4.4	-1.6	-2.1	-1.9	1.5	-1.9	-2.0	-2.1	-1.6	-1.6
Reaction Time	0.5	1.0	2.1	-1.4	-0.8	-1.5	0.9	-1.0	-0.9	-0.8	-0.6	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-0.6	0.4	-0.3	0.9	-0.8	-0.8	-0.8	-0.8	-1.0
Breast Cancer	1.1	2.6	3.9	0.8	2.0	2.0	-1.3	1.1	1.7	1.9	1.9	1.3
Ovarian Cancer	7.2	9.5	13.0	3.2	3.6	3.2	-2.7	3.0	3.2	3.1	3.0	2.6
Prostate Cancer	3.9	5.4	10.8	3.3	2.4	2.5	-1.7	2.3	2.3	2.3	2.1	1.6
Age at First Birth	1.1	1.6	2.8	-1.1	-0.9	-1.2	1.1	-1.4	-1.7	-1.5	-1.1	-1.4
Bipolar Disorder (2011)	6.8	6.6	12.0	-2.3	-2.9	-3.5	1.6	-2.4	-2.9	-2.9	-2.6	-1.5
Body Mass Index (BMI) (2010)	4.6	6.3	9.6	-3.1	-2.5	-2.0	2.5	-2.6	-2.6	-2.3	-2.4	-2.5
Coronary Artery Disease (CAD)	0.3	0.4	1.1	1.1	0.9	-0.1	-0.3	0.6	0.6	0.6	0.3	0.4
Crohns Disease (2012)	0.6	1.0	2.0	0.0	-0.8	-0.8	1.4	-0.2	-1.1	-1.1	-1.1	-1.4
Mean Putamen Volume	0.9	1.0	2.8	1.2	0.5	0.1	-1.6	0.9	0.6	0.6	0.7	1.7
Fasting Glucose	3.3	4.0	7.7	1.1	2.8	2.3	-1.3	1.9	1.9	2.4	2.2	1.4
HbA1C	4.7	5.2	6.5	-2.4	-1.9	-2.6	2.3	-2.3	-2.4	-2.3	-2.0	-2.3
HDL Cholesterol	7.4	12.3	29.2	-1.4	-5.4	-4.0	3.4	-2.9	-3.3	-3.2	-3.2	-3.4
LDL Cholesterol	0.8	1.2	2.0	0.4	1.0	1.0	-1.2	1.1	1.2	1.2	1.4	1.2
Lupus	0.3	0.4	2.1	-1.5	-0.6	0.3	0.1	-1.0	-0.1	-0.3	-0.3	-0.1
Neuroticism (2016)	1.0	1.4	2.8	1.4	0.3	1.0	-1.4	1.0	1.0	1.0	1.3	1.7
Primary Biliary Cirrhosis	1.5	2.1	3.5	0.1	-1.9	-1.5	1.7	-1.2	-1.2	-1.5	-1.6	-1.7
Rheumatoid Arthritis	1.8	2.5	4.8	0.3	1.5	2.2	-1.4	1.6	1.5	1.8	1.9	1.4
Schizophrenia (2014)	2.1	4.7	9.2	-0.5	-3.0	-2.6	1.4	-2.0	-2.1	-2.8	-2.4	-1.3
Triglycerides	0.1	0.1	0.4	-0.6	0.6	0.3	-0.4	0.1	0.2	0.1	0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.9	1.1	-0.4	-1.3	-0.3	-0.8	-0.6	-1.4	-1.0	0.4
Ulcerative Colitis	3.0	4.3	9.2	3.0	1.7	2.0	-1.6	2.8	2.0	1.7	1.8	1.7
Blood Eosinophil Count	4.5	34.5	106.1	10.3	3.8	4.5	-4.0	7.4	5.5	5.2	5.2	3.9
Blood Platelet Count	0.4	4.6	20.1	-4.5	-0.8	0.2	2.3	-2.6	-1.3	-0.8	-1.1	-2.3
Blood Red Count	7.2	69.5	108.2	-7.4	-10.4	-9.2	6.6	-8.6	-9.0	-8.4	-8.0	-6.5
Blood White Count	0.5	3.4	14.6	3.8	1.4	1.4	-0.3	2.1	1.6	1.8	1.5	0.3
Heel T-Score	0.4	2.9	5.3	-1.0	-2.2	-2.2	0.2	-2.3	-1.9	-1.9	-1.9	-0.2
BMI	2.4	13.8	18.1	-3.4	-3.6	-3.0	3.6	-3.7	-4.2	-4.2	-4.0	-3.5
Height	0.3	6.2	18.0	-3.1	-0.8	-1.8	4.2	-1.4	-1.5	-0.7	-1.2	-4.2
Waist Hip Ratio (WHR)	3.0	13.5	26.4	5.1	3.9	3.2	-1.9	4.3	4.1	3.9	3.5	1.9
Systolic Blood Pressure	0.2	0.9	4.5	-0.5	-0.7	-2.1	0.6	-0.6	-1.2	-0.5	-0.6	-0.6
Smoking Status	0.0	0.1	0.2	0.4	-0.4	0.0	0.3	0.3	0.1	-0.4	-0.4	-0.3
Allergy or Eczema	1.4	3.6	11.6	3.4	1.8	1.0	-2.0	2.0	1.4	1.0	1.0	2.0
Cardiovascular Disease	0.1	0.2	0.4	0.4	-0.5	-0.6	0.5	-0.4	-0.4	-0.6	-0.6	-0.4
Hypothyroidism (self reported)	2.1	4.8	12.1	-0.4	-3.5	-2.6	0.7	-1.6	-2.4	-3.0	-2.4	-0.8
Respiratory disease	1.0	2.2	5.4	2.3	1.6	1.0	-1.7	1.3	1.1	0.8	1.1	1.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	1.1	0.2	1.0	-0.3	0.7	0.5	0.7	0.6	0.2
Lung FEV1/FVC ratio	5.8	29.2	48.8	-5.6	-7.0	-5.1	3.0	-6.3	-5.5	-6.1	-5.7	-2.9
Lung FVC	0.1	0.6	1.2	0.4	0.0	-0.6	1.0	-0.0	-0.9	-1.0	-1.1	-0.9
Neuroticism	1.3	3.2	4.5	0.8	1.5	1.8	-2.0	1.4	2.1	1.8	2.0	2.1
Chronotype (morning person)	0.2	0.4	1.0	-1.0	0.6	0.1	1.0	-0.1	-0.2	-0.1	-0.2	-0.9
Hair Pigment	0.2	6.9	9.1	-2.5	-2.9	-3.0	2.0	-2.6	-2.8	-3.0	-2.6	-2.0
Tanning	0.0	0.6	1.2	0.1	-0.8	-0.7	0.8	-0.4	-0.6	-1.0	-1.1	-0.7
Hand grip strength (left)	0.0	0.1	0.2	-0.5	0.0	-0.0	0.5	0.1	0.0	0.2	0.3	-0.4
Number of treatments/medications taken	0.3	0.6	1.9	1.4	0.0	1.2	-0.5	0.8	0.6	0.2	0.3	0.6
Average weekly spirits intake	2.7	3.4	4.6	2.1	2.1	2.0	-1.2	2.0	1.7	2.1	1.8	1.2
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.9	-0.4	-0.2	0.8	-0.6	-0.3	-0.6	-0.6	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.4	0.1	0.6	-0.7	0.2	0.6	0.4	0.4	0.7
Hearing difficulty/problems: Yes	2.0	3.1	4.4	1.4	2.1	1.7	-2.0	1.3	2.0	1.5	1.6	2.1
Relative age of first facial hair	0.2	0.4	0.8	-0.7	-0.3	0.1	0.8	-0.7	-0.6	-0.3	-0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	-0.2	-0.3	0.2	0.1	-0.4	-0.4	-0.7	-0.7	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.2	-0.2	-0.0	0.5	-0.4	-0.3	-0.4	-0.4	-0.4
Ever had hysterectomy (womb removed)	0.5	0.5	1.1	-0.3	-0.7	-0.4	0.8	-0.8	-0.8	-0.9	-1.0	-0.6
Systolic blood pressure, automated reading	0.7	2.2	4.5	-1.5	-1.1	-2.1	1.2	-1.1	-1.7	-1.5	-1.5	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.3	-0.4	-0.0	0.6	-0.2	-0.4	-0.4	-0.6	-0.5
Angina	0.3	0.4	0.8	0.4	0.5	0.9	-0.7	0.5	0.7	0.5	0.6	0.7
Medication for hormone replacement therapy	0.8	0.9	1.8	-0.2	-0.8	-0.3	1.3	-0.7	-1.0	-0.9	-1.1	-1.3
Vitamin and mineral supplements	0.2	0.3	0.6	0.8	0.5	-0.7	0.6	0.5	-0.1	0.1	0.1	-0.6
Supplements: Zinc	0.3	0.3	0.9	-0.1	0.2	0.5	-0.9	0.2	0.6	0.4	0.4	0.9
Medication: Co-codamol	0.7	0.9	1.7	-1.0	-1.0	-0.6	0.5	-1.3	-0.8	-1.0	-1.1	-0.6
Medication: Metformin	0.4	0.5	1.3	1.1	0.3	0.8	-0.7	0.7	0.6	0.8	0.6	0.6
Diabetes (father)	1.6	2.0	2.9	-1.1	-1.7	-1.4	1.5	-1.0	-1.4	-1.3	-1.4	-1.6
Diabetes (mother)	4.4	5.6	8.4	1.3	2.1	2.4	-2.8	1.7	2.9	2.6	2.3	2.7
Severe depression (siblings)	0.4	0.5	0.9	0.8	0.6	0.1	-1.0	0.3	0.8	0.4	0.5	1.0
Pack years adult smoking proportion	0.9	1.4	2.8	1.7	1.3	1.0	-0.8	1.1	1.3	1.3	1.3	0.8
Impedance of leg (right)	1.6	7.6	11.2	2.9	2.5	2.4	-1.9	3.3	3.3	3.1	2.9	1.9
Leg fat-free mass (left)	1.7	9.2	14.6	-2.7	-2.4	-2.5	3.8	-2.8	-3.2	-2.9	-2.8	-3.7
Trunk fat percentage	0.6	2.2	5.5	-1.0	-1.7	-0.5	2.3	-0.9	-1.4	-1.1	-1.2	-2.3
Hand grip strength (right)	0.2	0.4	1.2	-0.7	-0.5	-0.6	1.1	-0.2	-0.6	-0.3	-0.2	-1.0
Townsend deprivation index at recruitment	0.7	0.9	3.3	1.8	0.4	0.7	-1.0	0.8	0.6	0.7	0.8	1.0
Current tobacco smoking	0.2	0.3	0.5	0.7	0.3	0.6	0.4	0.5	0.5	0.5	0.4	-0.5
Average weekly fortified wine intake	0.1	0.2	0.4	0.2	0.5	0.1	-0.5	0.6	0.3	0.4	0.5	0.4
Maternal smoking around birth	0.1	0.2	1.0	1.0	-0.1	0.7	0.4	0.3	-0.1	-0.1	-0.0	-0.3
Fed-up feelings	1.0	1.8	2.6	1.1	1.0	1.6	-1.5	1.0	1.5	1.4	1.4	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.4	5.1	1.6	1.6	2.1	-2.0	1.5	2.3	1.8	1.7	1.9
Relative age voice broke	1.3	2.0	3.4	-1.6	-0.9	-1.0	1.1	-1.8	-1.5	-1.4	-1.7	-1.1
Taking other prescription medications	2.8	4.3	7.0	2.7	1.3	1.9	-2.4	2.0	2.1	1.4	1.7	2.5
Age when periods started (menarche)	0.5	1.1	2.0	-1.2	-0.8	-0.9	0.9	-1.4	-1.0	-1.1	-1.2	-0.9
Bilateral oophorectomy (both ovaries removed)	5.7	6.6	8.9	-2.5	-2.4	-2.3	2.4	-2.8	-2.5	-2.8	-3.0	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	5.2	-0.9	-1.7	-1.1	1.0	-2.3	-1.8	-1.7	-1.9	-1.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.2	0.0	0.5	-0.4	0.4	0.3	0.5	0.1	0.4
Qualifications: CSEs or equivalent	0.5	0.6	1.7	-0.6	-1.3	-0.8	0.1	-0.7	-0.9	-1.0	-0.9	-0.0
Serious illness, injury or assault to yourself	0.3	0.4	1.4	0.2	0.8	1.2	0.5	0.4	0.5	0.4	0.1	-0.5
High blood pressure	0.0	0.1	0.1	0.3	-0.0	-0.3	0.3	-0.1	-0.2	-0.3	-0.2	-0.3
Hayfever, allergic rhinitis or eczema	1.4	3.1	9.4	3.1	1.4	1.0	-2.1	1.8	1.4	0.9	0.9	2.1
Multivitamins +/- minerals	0.5	0.6	2.0	-1.4	-1.0	0.3	-0.0	-1.0	-0.7	-0.7	-0.7	0.0
Stomach or abdominal pain in last month	0.4	0.5	2.4	-1.5	-0.8	-0.7	0.1	-0.8	-0.5	-0.5	-0.4	-0.0
Supplements: Glucosamine	0.3	0.3	1.3	-0.3	0.2	0.3	1.2	0.3	-0.3	0.0	-0.2	-1.2
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.0	0.7	1.9	0.9	-1.9	1.0	1.8	1.3	1.5	2.0
Medication: Atenolol	2.2	2.7	3.6	-1.9	-1.5	-1.3	1.8	-1.5	-1.7	-1.6	-1.7	-1.8
Medication: Levothyroxine sodium	0.6	1.0	2.5	-0.4	-1.6	-1.0	-0.5	-0.9	-1.0	-1.4	-1.1	0.5
Sitting height	1.7	12.1	20.3	-2.8	-3.0	-4.5	3.9	-2.6	-3.5	-3.5	-3.2	-3.8
Chronic bronchitis/emphysema (father)	0.4	0.4	0.8	0.8	-0.7	-0.3	0.9	0.0	-0.6	-0.7	-0.5	-0.9
High blood pressure (mother)	0.5	0.7	1.4	0.4	0.5	1.2	-1.1	0.4	0.9	0.8	0.6	1.0
Body mass index (BMI)	1.4	6.0	7.7	-2.3	-2.4	-1.5	2.8	-2.5	-2.8	-2.5	-2.5	-2.7
Impedance of leg (left)	1.0	4.8	8.0	2.1	1.9	1.8	-1.6	2.6	2.8	2.6	2.3	1.5
Leg predicted mass (left)	1.7	8.9	14.4	-2.6	-2.4	-2.4	3.8	-2.8	-3.2	-2.9	-2.8	-3.7
Trunk fat mass	1.2	5.3	11.6	-1.9	-2.1	-1.3	3.4	-1.7	-2.2	-1.9	-2.0	-3.3
Waist circumference	0.7	2.5	7.6	-0.6	-1.0	-0.5	2.8	-1.1	-1.4	-1.1	-1.4	-2.7
Number of incorrect matches in round	0.6	0.9	2.1	0.2	1.0	0.4	-1.0	0.7	1.5	1.1	0.9	1.1
Past tobacco smoking	0.1	0.1	0.7	-0.8	0.1	-0.1	0.4	-0.1	-0.2	0.3	0.4	-0.4
Alcohol usually taken with meals	1.9	3.0	5.2	-1.4	-2.2	-2.3	1.0	-1.5	-2.0	-1.9	-1.7	-1.1
Nervous feelings	1.5	2.8	6.7	0.7	1.4	1.0	-2.5	1.2	1.9	1.2	1.4	2.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.7	0.8	0.4	1.2	-1.0	0.9	1.3	0.9	1.1	1.0
Hearing difficulty/problems with background noise	0.7	1.0	2.4	1.1	1.2	0.0	-1.4	0.6	1.0	0.5	0.8	1.5
Hair/balding pattern: Pattern 2	3.5	4.4	5.3	-1.9	-2.2	-2.1	1.9	-2.3	-2.3	-2.0	-2.2	-1.9
Had menopause	0.6	0.8	2.0	1.4	0.8	-0.0	-1.0	0.8	1.0	0.7	0.7	1.0
Had other major operations	0.2	0.3	0.6	-0.5	-0.7	0.1	-0.1	-0.8	-0.4	-0.6	-0.7	0.2
Forced vital capacity (FVC)	0.1	0.4	1.3	-0.3	0.6	-0.3	1.2	0.5	-0.5	-0.1	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	2.6	-0.4	-0.9	-0.8	0.4	-1.6	-1.2	-1.1	-1.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.4	-0.3	0.3	-0.2	0.0	0.1	-0.1	-0.1	0.3
Qualifications: None of the above	2.4	5.2	6.5	2.2	2.0	2.2	-2.0	2.5	2.5	2.5	2.5	2.0
Financial difficulties in last 2 years	0.2	0.2	0.7	0.5	0.1	0.1	0.8	0.3	0.2	0.4	0.2	-0.8
Mouth/teeth dental problems	1.3	2.1	5.2	-0.5	-1.2	-1.2	2.2	-0.4	-1.5	-1.2	-1.2	-2.3
Heart attack	1.9	2.4	3.6	1.4	1.0	1.1	-1.8	1.5	1.7	1.4	1.8	1.9
Allergy	1.6	3.6	11.2	-3.4	-1.5	-0.9	2.2	-2.0	-1.5	-1.0	-1.1	-2.2
Pain all over the body in last month	1.9	2.0	2.7	1.5	1.1	1.4	-1.4	1.3	1.6	1.5	1.4	1.4
Diabetes (self-reported)	0.1	0.2	0.9	0.9	-0.0	0.1	-0.2	0.5	0.3	0.5	0.4	0.0
Hayfever/allergic rhinitis (self-reported)	5.2	6.9	9.3	3.0	2.8	2.4	-2.3	2.5	2.9	2.8	2.6	2.3
Medication: Ramipril	0.5	0.6	1.0	0.5	0.8	0.9	-1.0	0.6	0.9	0.6	0.6	1.0
Medication: Simvastatin	0.4	0.6	1.2	0.8	-1.1	-0.3	0.6	-0.6	-0.6	-0.9	-1.1	-0.7
Fluid intelligence score	0.2	0.5	1.7	-0.3	0.8	-0.1	1.2	-0.2	-0.4	-0.4	-0.4	-1.3
Illnesses of siblings	0.1	0.2	1.1	-1.0	-0.2	-0.4	-0.3	0.3	-0.1	-0.1	0.3	0.2
Neuroticism score	2.5	5.3	7.1	1.3	2.0	2.6	-2.4	2.1	2.7	2.4	2.5	2.4
Weight	1.9	9.1	17.0	-2.9	-2.4	-2.1	4.1	-2.6	-3.0	-2.7	-2.8	-4.0
Impedance of arm (right)	0.8	3.8	7.2	2.3	1.1	1.7	-1.4	2.7	2.1	2.2	2.1	1.4
Arm fat percentage (right)	1.3	5.2	7.9	-1.9	-2.5	-1.2	2.8	-2.1	-2.5	-2.2	-2.3	-2.7
Trunk fat-free mass	2.0	11.5	18.9	-3.3	-2.2	-3.1	4.3	-3.1	-3.3	-3.2	-3.2	-4.2
Hip circumference	0.9	3.8	6.6	-1.8	-1.7	-1.1	2.6	-1.8	-2.1	-1.8	-1.9	-2.4
Time employed in main current job	0.2	0.2	0.4	-0.6	-0.0	0.0	-0.4	0.5	0.1	0.4	0.7	0.4
Alcohol intake versus 10 years previously	0.8	1.2	3.8	-0.7	-0.7	-0.0	1.9	-0.9	-0.9	-0.7	-0.8	-1.9
Father’s age at death	0.5	0.7	1.4	-1.2	-0.6	-1.1	0.7	-0.4	-0.7	-1.0	-0.8	-0.7
Worrier / anxious feelings	0.9	1.6	2.3	0.6	1.3	1.4	-1.4	0.8	1.5	1.2	1.3	1.5
Frequency of tiredness / lethargy in last 2 weeks	3.2	5.2	10.9	3.3	1.8	2.8	-2.0	2.1	2.4	1.8	1.9	2.0
Falls in the last year	1.3	1.8	3.8	1.5	2.0	1.1	-0.8	1.5	1.3	1.3	1.4	0.8
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	-0.4	0.8	0.5	-1.0	0.4	0.3	0.3	0.6	0.9
Number of live births	0.1	0.2	0.4	0.3	-0.6	-0.5	-0.1	-0.6	-0.3	-0.3	-0.2	0.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	4.6	-2.1	-1.7	-2.0	2.0	-1.5	-2.1	-1.9	-1.9	-1.9
Pulse rate	0.2	0.3	0.8	-0.2	-0.5	-0.8	0.9	-0.3	-0.3	-0.2	-0.2	-0.9
Happiness	0.2	0.2	0.3	-0.5	0.6	0.4	0.4	-0.3	0.4	0.5	0.4	-0.4
Noisy workplace	0.8	0.9	4.7	-0.4	0.6	2.2	-0.7	0.1	0.9	1.0	0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	-0.0	0.3	-0.6	0.1	-0.2	-0.3	-0.6	-0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.5	1.9	1.1	1.4	-0.6	1.0	0.9	1.1	0.8	0.6
Mouth/teeth dental problems: Dentures	3.9	6.5	7.8	2.7	2.3	2.3	-2.8	2.4	2.6	2.6	2.6	2.8
Asthma	1.0	2.0	4.0	2.0	1.7	1.1	-1.7	1.0	1.1	0.8	1.0	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	1.1	0.3	0.7	-0.2	1.1	0.6	0.7	0.8	0.2
Medication: Cholesterol lowering	0.5	0.7	1.9	1.4	0.2	0.7	-0.8	1.1	0.8	0.7	0.8	0.8
Depression (self-reported)	1.9	2.3	4.7	2.2	1.6	0.8	-1.4	1.7	1.8	1.3	1.2	1.4
Medication: Lansoprazole	0.1	0.2	0.4	0.5	-0.7	-0.2	0.4	-0.2	-0.3	-0.4	-0.5	-0.3
Prospective memory result	0.3	0.4	1.3	-0.7	-1.1	-0.1	0.5	-0.9	-0.6	-0.3	-0.5	-0.4
Lung cancer (father)	0.6	0.7	1.4	-1.2	-1.1	-0.5	0.3	-1.1	-0.9	-0.8	-0.7	-0.1
Illnesses of mother	0.8	0.9	2.2	-1.0	-0.7	-1.5	0.6	-1.0	-1.1	-1.1	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	4.9	-2.2	-1.7	-1.7	2.0	-1.7	-2.2	-1.9	-1.9	-1.9
Pulse wave Arterial Stiffness index	1.0	1.1	2.5	-0.4	-1.6	-1.4	1.1	-0.7	-0.9	-1.1	-0.9	-1.0
Impedance of arm (left)	1.0	4.6	8.6	2.4	1.4	2.0	-1.6	2.9	2.3	2.4	2.3	1.5
Arm fat mass (right)	2.2	8.9	14.7	-2.5	-2.8	-1.9	3.8	-2.7	-3.2	-2.8	-2.9	-3.7
Trunk predicted mass	1.9	11.0	18.3	-3.2	-2.2	-3.1	4.3	-3.1	-3.3	-3.1	-3.1	-4.1
Standing height	0.5	4.5	14.0	-1.8	-0.6	-1.9	3.7	-0.8	-1.3	-1.1	-1.3	-3.7
Length of working week for main job	0.1	0.1	0.5	-0.5	-0.2	0.1	0.7	-0.1	-0.1	0.0	-0.2	-0.5
Exposure to tobacco smoke at home	1.4	1.6	3.0	1.0	1.0	1.1	-1.6	0.6	1.4	1.1	1.3	1.7
Breastfed as a baby	0.1	0.1	0.2	0.3	-0.2	-0.1	-0.3	-0.1	-0.2	-0.4	-0.3	0.2
Tense / ‘highly strung’	1.4	2.3	3.2	1.7	1.2	1.4	-1.6	1.6	1.8	1.3	1.4	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	1.0	0.4	-0.0	-0.6	0.4	0.7	-0.1	0.1	0.7
Hair/balding pattern: Pattern 4	0.7	1.7	6.9	0.3	0.2	-1.1	2.6	0.2	-0.3	-0.1	-0.6	-2.6
Birth weight of first child	1.4	2.5	3.7	1.2	1.2	1.9	-1.8	1.5	1.6	1.5	1.6	1.8
Peak expiratory flow (PEF)	3.1	7.1	8.6	-2.9	-2.7	-2.7	2.3	-2.7	-2.9	-2.8	-2.7	-2.2
Pulse wave reflection index	0.4	0.5	1.0	-0.3	-1.0	-0.6	0.6	-0.5	-0.7	-0.9	-0.8	-0.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.6	0.6	0.6	1.1	0.1	1.3	1.1	1.1	1.0	0.0
Loud music exposure frequency	0.3	0.4	0.9	-0.7	-0.5	-0.2	0.9	-0.4	-0.7	-0.4	-0.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-0.1	-0.7	-0.9	0.6	-0.6	-0.9	-0.9	-0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	4.9	-2.2	-1.2	-0.8	0.9	-1.8	-1.0	-0.9	-1.1	-0.7
Blood clot in the leg (DVT)	0.5	0.7	1.9	-1.2	-1.3	-1.4	0.3	-0.6	-0.5	-0.6	-0.3	-0.3
Medication: Paracetamol	0.2	0.4	1.4	0.4	0.2	1.2	0.2	0.6	0.6	0.7	0.6	-0.1
Headache pain in last month	0.4	0.7	1.4	-1.2	-0.9	0.2	1.0	-0.9	-0.8	-0.9	-0.6	-0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.0	-0.9	-0.6	-0.6	0.9	-0.9	-0.7	-0.8	-0.8	-1.0
Glaucoma (self-reported)	0.1	0.1	0.5	-0.0	0.2	-0.1	-0.0	0.7	0.3	0.2	0.4	0.1
Gout (self-reported)	4.9	6.7	8.4	2.5	2.2	2.2	-2.9	2.7	2.6	2.5	2.5	2.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	5.9	-0.4	-2.4	-1.7	0.3	-1.0	-1.6	-2.1	-1.7	-0.3
Medication: Amlodipine	0.2	0.3	0.9	0.7	0.4	0.3	-0.9	-0.0	0.2	-0.3	0.0	0.9
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.4	1.8	0.8	0.0	-1.5	0.8	0.6	0.3	0.6	1.5
Birth weight	6.8	14.8	22.3	2.6	4.7	4.0	-3.4	3.8	4.3	4.0	4.1	3.4
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.0	1.2	1.2	1.5	-1.7	0.7	1.6	1.3	1.6	1.6
High blood pressure (siblings)	1.2	1.7	2.8	-0.7	-0.9	-0.9	1.5	-1.5	-1.3	-1.4	-1.7	-1.5
Forced vital capacity (FVC), Best measure	0.2	0.6	1.8	-0.6	0.0	-0.6	1.3	-0.1	-0.9	-0.6	-0.6	-1.2
Body fat percentage	0.5	2.2	5.2	-1.1	-1.6	-0.5	2.3	-1.0	-1.4	-1.0	-1.3	-2.2
Leg fat percentage (right)	0.2	0.9	2.7	-0.8	-0.8	0.2	1.6	-0.6	-0.7	-0.5	-0.7	-1.5
Arm fat-free mass (right)	1.9	9.5	14.7	-3.0	-2.1	-2.9	3.8	-3.0	-3.0	-3.0	-2.9	-3.7
Exposure to tobacco smoke outside home	2.1	2.7	4.5	1.1	1.4	1.5	-1.8	1.5	1.8	1.8	2.1	1.8
Comparative body size at age 10	6.2	17.2	20.9	-4.4	-4.1	-3.2	4.6	-4.4	-4.1	-3.9	-4.0	-4.4
Number of full brothers	2.2	2.8	4.0	1.8	1.7	1.3	-1.7	1.3	1.6	2.0	1.7	1.7
Worry too long after embarrassment	1.2	2.1	3.3	1.0	1.4	1.4	-1.6	1.2	1.8	1.4	1.3	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.8	0.7	0.6	-0.7	0.3	0.7	0.5	0.3	0.8
Wheeze or whistling in the chest in last year	5.3	9.4	18.8	4.3	2.9	2.1	-3.0	3.2	3.0	2.7	2.9	3.0
Number of children fathered	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.1	-0.3	-0.2	-0.2	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.7	-0.4	-0.5	-0.5	0.8	-0.7	-0.7	-0.5	-0.7	-0.8
Age at first live birth	1.7	3.0	4.1	-1.6	-1.2	-2.0	1.6	-1.6	-1.8	-2.0	-1.9	-1.6
Pulse wave peak to peak time	0.7	0.8	2.3	0.4	1.5	1.3	-0.7	0.7	0.8	1.0	0.8	0.6
Health satisfaction	0.0	0.1	0.2	-0.1	0.3	0.4	0.2	-0.2	0.4	0.2	0.1	-0.1
Shortness of breath walking on level ground	1.0	1.2	2.3	1.5	1.2	0.5	-0.7	1.0	1.3	1.2	1.2	0.8
Qualifications: College or University degree	1.4	4.3	7.9	-1.1	-1.1	-1.9	2.7	-1.5	-2.1	-2.2	-2.2	-2.8
Eye problems/disorders: None of the above	0.8	1.0	1.8	0.0	1.4	0.9	-1.0	0.9	0.9	1.0	1.2	1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	1.2	0.2	0.8	-0.9	0.6	0.7	0.7	0.8	0.9
Emphysema/chronic bronchitis	5.0	5.6	9.5	3.1	2.7	2.3	-2.0	2.4	2.4	2.1	2.0	2.1
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	-1.2	-0.2	-1.3	0.2	-1.1	-1.0	-0.9	-1.0	-0.3
Neck or shoulder pain in last month	0.8	1.1	2.6	-0.6	-1.6	-0.5	0.6	-1.5	-1.0	-1.3	-1.2	-0.6
Medication: Blood pressure	0.1	0.1	0.5	0.1	0.7	-0.0	-0.1	0.4	0.3	0.2	0.4	0.2
Angina (self-reported)	0.3	0.4	0.8	0.3	0.5	0.9	-0.9	0.5	0.7	0.5	0.6	0.9
Migraine (self-reported)	7.8	9.6	13.2	-3.6	-3.0	-2.8	3.1	-3.0	-3.3	-3.0	-3.1	-3.1
Medication: Ibuprofen	0.4	0.4	1.6	1.3	0.1	0.4	-0.4	1.0	0.4	0.4	0.6	0.5
Medication: Allopurinol	3.8	5.0	5.9	1.6	2.1	2.3	-2.3	2.3	2.3	2.2	2.4	2.4
Medication: Omeprazole	0.1	0.2	0.6	0.8	-0.5	0.2	0.4	-0.3	-0.1	-0.2	-0.3	-0.3
Medication: Seretide 50 evohaler	6.1	7.0	12.5	3.5	2.9	2.6	-1.8	3.0	2.3	2.6	2.7	1.8
Mean time to correctly identify matches	0.2	0.5	1.6	-1.3	-0.4	-1.0	0.1	-1.0	-0.4	-0.6	-0.3	-0.0
Heart disease (mother)	0.8	1.0	1.7	-0.5	-1.2	-1.3	0.7	-1.0	-1.0	-1.2	-1.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.2	-0.4	0.3	0.3	-1.4	-0.4	0.5	0.5	0.4	1.5
Whole body fat mass	1.4	5.7	11.6	-2.1	-2.2	-1.3	3.4	-2.0	-2.3	-2.0	-2.1	-3.3
Leg fat mass (right)	1.4	5.5	11.6	-1.8	-2.1	-1.3	3.4	-2.0	-2.3	-2.0	-2.2	-3.3
Arm predicted mass (right)	2.3	11.6	17.5	-3.2	-2.4	-3.3	4.2	-3.3	-3.4	-3.3	-3.2	-4.1
Pulse rate, automated reading	0.1	0.4	1.3	0.8	0.3	0.6	0.1	1.2	0.5	0.5	0.7	-0.1
Alcohol intake frequency.	0.0	0.1	0.4	-0.3	-0.7	0.4	0.1	-0.4	-0.2	-0.2	-0.2	-0.1
Comparative height size at age 10	0.4	2.1	8.0	-0.9	-0.6	-0.8	2.8	-0.1	-0.6	-0.7	-0.8	-2.8
Number of full sisters	1.1	1.3	3.6	1.3	1.0	1.9	-0.6	1.0	1.2	1.2	1.2	0.6
Suffer from ‘nerves’	1.7	2.6	6.5	0.7	1.1	0.8	-2.5	0.9	1.7	1.5	1.5	2.5
Overall health rating	0.7	1.5	2.2	1.4	0.8	0.9	-1.1	1.1	1.5	1.4	1.5	1.1
Chest pain or discomfort	8.0	11.5	22.1	4.7	3.2	2.7	-3.3	3.4	3.5	3.0	3.1	3.3
Had major operations	1.2	1.4	2.5	1.0	1.4	1.6	-0.9	1.6	1.0	1.0	1.0	0.9
Age at last live birth	1.4	2.0	2.7	-1.2	-1.1	-1.3	1.5	-1.4	-1.4	-1.6	-1.6	-1.5
Family relationship satisfaction	0.5	0.7	2.2	0.1	-0.3	-0.2	1.5	-0.6	-0.5	-0.6	-0.8	-1.4
Leg pain on walking	0.5	0.6	1.3	1.2	0.9	0.3	-0.4	0.9	1.0	0.9	0.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.1	-2.0	-0.6	-0.3	1.4	-1.6	-0.9	-0.6	-0.7	-1.3
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.5	0.7	-0.0	-0.3	0.3	-0.6	-0.2	-0.4	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	2.1	-1.4	-0.1	-0.6	-0.2	0.0	-0.5	-0.5	-0.1	0.2
Medication: Aspirin	0.4	0.5	1.4	1.2	0.2	0.8	0.1	1.1	0.7	0.6	0.6	-0.1
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	-0.2	-0.0	-0.3	0.0	0.1	0.2	0.2	0.3
Knee pain experienced in last month	0.6	1.0	2.2	1.5	0.6	1.1	-0.9	1.0	1.1	0.8	0.8	1.0
Hypertension (Self-reported)	0.1	0.2	0.3	0.0	-0.3	-0.5	0.3	-0.4	-0.5	-0.6	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	0.8	0.1	0.0	-0.0	0.1	0.0	-0.2	-0.3	0.1
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.2	0.7	0.8	0.1	0.0	0.5	0.1	-0.1	-0.1
Illnesses of siblings: Diabetes	2.4	2.9	4.4	1.1	1.5	1.8	-2.1	1.2	1.7	1.6	1.9	2.1
Smoking status: Previous	0.2	0.2	0.5	0.5	-0.3	-0.4	-0.7	-0.0	-0.1	-0.6	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.4	-2.1	-0.6	-0.4	1.0	-1.0	-0.8	-0.5	-0.4	-1.0
Whole body fat-free mass	2.0	11.2	17.8	-3.1	-2.4	-3.1	4.2	-3.1	-3.4	-3.2	-3.1	-4.1
Leg fat-free mass (right)	1.7	9.3	13.5	-2.9	-2.4	-2.6	3.7	-3.0	-3.2	-2.9	-2.9	-3.6
Arm fat percentage (left)	1.2	4.9	8.0	-1.9	-2.4	-1.1	2.8	-2.0	-2.4	-2.1	-2.2	-2.7
Average weekly red wine intake	3.2	4.8	5.7	2.2	2.2	2.0	-2.3	2.2	2.0	2.2	2.1	2.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	-0.5	1.0	0.8	-0.9	0.4	0.8	0.3	0.5	0.9
Mood swings	0.1	0.1	0.6	-0.8	-0.5	-0.3	0.0	-0.5	0.0	-0.1	-0.1	-0.0
Loneliness, isolation	1.7	2.3	2.8	1.5	1.0	1.5	-1.7	1.5	1.6	1.5	1.6	1.7
Long-standing illness, disability or infirmity	1.1	1.7	2.2	1.1	1.3	1.0	-1.4	1.3	1.5	1.2	1.4	1.5
Ever had bowel cancer screening	0.4	0.5	1.1	-0.1	1.0	0.8	-0.8	0.4	1.0	0.4	0.3	0.8
Diabetes diagnosed by doctor	0.3	0.5	1.7	1.3	0.2	0.3	-0.4	0.9	0.7	0.8	0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.5	-0.2	-0.4	0.3	-0.0	0.0	-0.2	-0.3	-0.2
Friendships satisfaction	0.1	0.1	0.5	0.2	0.2	-0.7	0.5	-0.2	0.1	-0.1	-0.1	-0.4
Qualifications: nursing, teaching	0.6	1.0	2.2	0.9	-1.0	-1.5	0.4	-0.9	-0.9	-1.2	-1.2	-0.4
Commuting to job workplace: Walk	0.3	0.4	0.9	-0.2	-0.6	-0.5	0.8	-0.2	-0.7	-0.7	-0.5	-0.9
Eye problems/disorders: Cataract	1.2	1.4	2.3	-0.4	-1.5	-1.0	1.2	-1.2	-1.3	-1.1	-1.3	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.7	-2.1	-1.2	-1.0	0.9	-2.2	-1.4	-1.5	-1.7	-0.9
Medication for cholesterol	1.6	2.4	3.7	-0.0	1.6	1.4	-1.8	1.2	1.5	1.7	1.9	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.8	2.0	1.5	1.5	-1.3	1.3	1.7	1.3	1.2	1.3
Back pain experienced in last month	0.1	0.1	0.3	-0.6	-0.5	-0.2	0.5	-0.4	-0.1	-0.2	-0.0	-0.4
Mineral and other dietary supplements	0.2	0.3	0.7	0.9	0.2	0.1	-0.5	0.6	0.6	0.6	0.7	0.5
Breast cancer (self-reported)	0.3	0.4	1.1	0.6	0.1	1.0	-0.6	0.7	0.3	0.6	0.6	0.5
Asthma (self-reported)	1.1	2.1	4.0	2.0	1.8	1.2	-1.7	1.1	1.2	0.8	1.0	1.8
Osteoporosis (self-reported)	1.7	2.1	3.1	1.8	1.5	1.0	-1.4	1.7	1.5	1.3	1.4	1.5
Osteoarthritis (self-reported)	0.7	1.0	1.3	-0.8	-1.2	-0.8	1.1	-0.7	-1.0	-1.0	-1.0	-1.1
Medication: Aspirin	0.4	0.5	1.7	1.3	0.1	0.9	-0.0	1.1	0.7	0.5	0.5	-0.0
Medication: Gliclazide	0.5	0.5	1.6	0.1	0.1	0.0	-1.3	0.5	0.4	0.8	0.7	1.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.5	-0.6	-0.3	-0.7	0.1	-0.2	-0.3	-0.0	0.2	-0.0
Smoking status: Current	0.2	0.3	0.6	0.6	0.4	0.8	0.4	0.6	0.6	0.5	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	4.7	-2.0	-2.1	-1.9	1.6	-2.0	-2.2	-2.1	-2.1	-1.5
Whole body water mass	2.1	12.1	18.6	-3.2	-2.6	-3.2	4.3	-3.3	-3.5	-3.4	-3.3	-4.2
Leg predicted mass (right)	1.7	9.3	13.6	-2.9	-2.4	-2.6	3.7	-2.9	-3.2	-2.9	-2.9	-3.6
Arm fat mass (left)	2.4	9.8	15.8	-2.8	-2.9	-2.0	4.0	-2.8	-3.3	-2.9	-3.0	-3.9
Number of self-reported non-cancer illnesses	1.3	2.3	5.6	2.4	1.4	0.8	-1.8	1.4	1.4	0.9	0.9	1.8
Average weekly champagne plus white wine intake	3.5	4.8	6.2	-1.7	-2.4	-2.5	1.9	-2.3	-2.1	-2.3	-2.4	-1.9
Miserableness	1.2	2.0	3.1	1.0	1.5	1.8	-1.4	1.0	1.7	1.5	1.5	1.3
Guilty feelings	4.4	6.6	8.2	2.1	2.5	2.7	-2.3	2.7	2.8	2.8	2.9	2.3
Wears glasses or contact lenses	0.7	0.9	1.4	-0.9	-0.6	-0.6	1.1	-1.2	-0.9	-0.8	-1.1	-1.0
Ever taken oral contraceptive pill	1.9	2.2	3.1	1.2	1.6	1.6	-1.7	1.3	1.5	1.2	1.2	1.8
Hearing aid user	0.6	0.7	1.7	0.1	1.1	1.3	-0.1	0.8	0.8	1.1	0.9	-0.0
Mother’s age at death	1.3	1.7	2.3	-1.1	-1.5	-1.5	1.2	-1.0	-1.4	-1.4	-1.3	-1.2
Financial situation satisfaction	0.3	0.4	0.8	0.8	0.9	0.8	-0.2	0.2	0.9	0.5	0.2	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.6	0.7	0.6	-0.7	0.3	0.7	0.4	0.4	0.7
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.9	-0.2	-0.5	0.4	-0.8	-0.5	-0.9	-1.0	-0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.3	0.2	-0.3	-0.3	-0.2	-0.3
Medication: Blood pressure	0.8	1.6	2.4	-0.1	-1.5	-1.4	1.3	-0.9	-1.3	-1.5	-1.5	-1.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	0.9	-0.1	0.5	-0.9	0.3	0.5	0.0	0.2	1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.1	0.7	1.1	-1.0	0.3	0.6	0.4	0.3	1.1
High cholesterol (Self-reported)	0.3	0.5	3.9	2.0	-0.6	-0.2	-0.3	0.5	0.3	-0.3	-0.3	0.3
Medication: Bendroflumethiazide	1.2	1.8	3.5	0.0	-1.0	-1.9	1.4	-1.1	-1.3	-1.5	-1.7	-1.4
Medication: Paracetamol	0.4	0.7	3.1	0.5	0.6	1.8	-0.5	0.6	0.9	0.8	0.6	0.5
Medication: Lisinopril	0.2	0.2	0.4	0.6	0.6	0.6	0.1	0.6	0.3	0.5	0.4	-0.0
Medication: Atorvastatin	0.6	0.8	1.4	0.5	0.7	0.9	-0.6	1.1	1.0	1.1	1.2	0.6
Illnesses of father: High blood pressure	0.6	0.7	1.7	-0.5	-0.9	-0.8	0.4	-0.8	-1.0	-1.3	-1.2	-0.4
Alcohol drinker status: Never	2.0	2.4	3.3	1.5	1.3	1.4	-1.8	1.8	1.6	1.3	1.5	1.8
Ever smoked	0.3	0.5	1.0	-0.2	-0.9	-0.8	0.3	-0.7	-0.5	-1.0	-1.0	-0.2
Basal metabolic rate	2.1	11.5	19.1	-3.2	-2.5	-2.9	4.4	-3.1	-3.4	-3.1	-3.2	-4.2
Leg fat percentage (left)	0.6	2.1	4.4	-1.4	-1.4	-0.4	2.1	-1.3	-1.3	-1.0	-1.3	-2.0
Arm fat-free mass (left)	2.5	12.5	19.0	-3.3	-2.5	-3.4	4.4	-3.4	-3.5	-3.4	-3.4	-4.2
Number of operations (self-reported)	1.3	1.9	3.2	-0.9	-1.7	-0.7	1.2	-1.4	-1.6	-1.7	-1.8	-1.1
Average weekly beer plus cider intake	2.6	3.7	6.0	1.5	2.0	2.5	-1.6	2.0	1.9	2.1	2.2	1.6
Irritability	0.1	0.1	0.5	0.0	-0.7	0.2	0.3	0.0	0.0	-0.6	-0.4	-0.3
Risk taking	0.5	0.7	1.4	0.5	-0.6	-0.6	1.2	0.1	-0.7	-1.2	-1.0	-1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	0.7	1.0	1.0	-1.2	0.8	0.9	0.6	0.7	1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-1.1	-0.5	-0.4	1.0	-0.4	-0.5	-0.4	-0.4	-0.9
Age started oral contraceptive pill	0.1	0.2	0.7	-0.6	0.0	-0.8	-0.1	-0.3	-0.3	-0.2	-0.1	0.3
Diastolic blood pressure, automated reading	2.4	7.5	10.3	-3.2	-2.4	-3.0	2.6	-2.4	-2.9	-2.8	-2.7	-2.5
Ever depressed for a whole week	0.2	0.3	0.5	-0.3	-0.7	-0.7	0.5	-0.2	-0.4	-0.6	-0.5	-0.5
Unable to work because of sickness or disability	0.6	0.7	1.1	0.7	0.9	0.6	-1.1	0.5	0.9	0.9	1.0	1.0
Commuting to job workplace: Cycle	0.6	0.8	1.5	0.2	0.9	1.1	-0.5	1.2	0.8	1.0	1.1	0.3
Myopia	2.3	3.4	6.9	-2.6	-1.8	-1.5	0.6	-2.0	-2.0	-2.3	-2.0	-0.5
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.5	-0.7	-0.2	0.1	0.1	-0.2	-0.2	0.0	-0.1	-0.2
Cholesterol lowering medication	0.5	0.7	1.6	1.2	-1.2	-0.8	0.6	-0.5	-0.6	-0.9	-1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	-0.0	-1.1	-0.1	1.1	-0.9	-0.7	-0.7	-0.8	-1.0
Pain experienced in last month	0.1	0.2	0.5	0.7	0.5	-0.6	-0.4	0.4	-0.1	0.1	-0.1	0.3
Supplements: Calcium	2.0	2.2	3.6	1.9	1.4	1.0	-1.7	1.5	1.3	1.2	1.3	1.7
Basal cell carcinoma (self-reported)	0.5	0.5	1.4	1.0	1.2	0.6	-0.4	0.3	0.7	1.0	0.5	0.4
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.4	1.5	0.9	1.0	-1.8	1.4	1.7	1.4	1.7	1.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.7	-1.2	-1.2	-1.3	0.1	-0.4	-0.4	-0.5	-0.1	-0.1
Heart disease (siblings)	0.7	0.9	2.0	1.4	0.7	1.3	-0.6	0.6	0.9	1.1	0.9	0.6
Alcohol drinker status: Previous	0.1	0.1	0.2	0.2	-0.4	0.1	0.1	-0.3	-0.0	-0.4	-0.4	-0.2
Pack years of smoking	0.7	1.0	1.9	1.4	1.1	0.9	-0.6	0.9	1.1	1.1	1.1	0.5
Impedance of whole body	1.7	8.5	13.2	3.0	2.3	2.6	-2.3	3.6	3.3	3.3	3.1	2.2
Leg fat mass (left)	1.8	7.2	13.2	-2.3	-2.5	-1.7	3.6	-2.4	-2.7	-2.3	-2.5	-3.5
Arm predicted mass (left)	2.5	12.8	19.2	-3.4	-2.6	-3.4	4.4	-3.5	-3.5	-3.4	-3.5	-4.3