Hub : Genes

PIK3R6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.3970	0.0660	1.7e-08	0.350	NA	0.385	NA	0.391	2.5e-16	NA	3.4e-18	NA	1.6e-18
2	TCGA	Breast Invasive Carcinoma	0.0360	0.0163	7.9e-04	0.002	0.008	0.000	NA	0.005	9.9e-02	8.8e-03	3.2e-01	NA	2.2e-02
3	TCGA	Lung Adenocarcinoma	0.0687	0.0317	1.7e-03	0.010	0.034	0.015	NA	0.014	2.4e-02	6.1e-05	6.9e-03	NA	8.4e-03
4	TCGA	Lung Squamous Cell Carcinoma	0.0799	0.0352	8.1e-04	0.006	0.027	0.019	NA	0.027	5.6e-02	4.7e-04	2.9e-03	NA	4.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.4	0.8	0.9	-0.6	0.6	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.2	0.5	-1.1	-0.0	0.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	-0.2	0.6	-1.1	0.9
Depression (Nagel 2018)	1.2	1.8	5.1	0.6	2.3	1.1	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.2	0.8	0.6	-1.1	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.5	-0.2	0.0	-1.1	1.2
Schizophrenia (2018)	0.2	0.4	1.1	-0.1	-1.1	-0.5	0.4
Schizophrenia vs Biploar Disorder	0.5	0.7	2.2	0.0	-0.5	-1.5	-0.4
Worry (Nagel 2018)	0.3	0.6	1.3	-0.1	0.2	-1.1	1.1
Alzheimer’s Disease (in mother)	0.8	0.9	2.5	-1.6	0.4	-0.3	1.0
Alzheimer’s Disease (in father)	2.6	2.8	5.9	2.4	-0.5	-0.2	-2.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.1	-0.2	0.5	0.2
Crohns Disease (2017)	0.0	0.0	0.1	0.1	0.2	-0.2	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.3	0.3	-0.3	0.7
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.1	0.2	-0.3	0.7
Major Depression (MDD)	0.8	1.0	2.5	0.0	-1.2	-1.6	-0.1
Reaction Time	0.1	0.3	0.5	0.7	-0.2	-0.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.4	1.6	-0.0	-1.8	-1.6
Breast Cancer	0.6	1.4	3.5	-0.3	1.9	1.4	-0.3
Ovarian Cancer	0.3	0.4	1.0	1.0	-0.0	-0.1	-0.7
Prostate Cancer	0.5	0.8	1.7	0.9	-0.4	0.6	-1.3
Age at First Birth	0.6	0.9	3.0	1.7	-0.3	0.7	0.1
Bipolar Disorder (2011)	0.6	0.6	2.5	1.6	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.1	-0.1	0.0	-0.6
Coronary Artery Disease (CAD)	1.0	1.2	4.0	0.3	0.3	-2.0	-0.7
Crohns Disease (2012)	0.8	1.2	2.4	1.5	-1.6	-0.4	-0.3
Mean Putamen Volume	0.2	0.2	0.7	0.0	-0.4	0.8	0.2
Fasting Glucose	1.0	1.2	2.6	1.1	-1.0	0.2	-1.6
HbA1C	1.6	1.8	4.8	0.3	-1.6	-2.2	0.1
HDL Cholesterol	0.3	0.5	1.7	-0.3	1.3	0.1	0.4
LDL Cholesterol	0.4	0.6	2.2	1.5	0.2	0.0	-0.2
Lupus	0.5	0.8	1.3	-0.8	-0.4	1.1	1.0
Neuroticism (2016)	0.1	0.2	0.3	0.6	-0.6	-0.2	-0.2
Primary Biliary Cirrhosis	0.4	0.6	1.0	-0.6	0.7	1.0	0.7
Rheumatoid Arthritis	0.1	0.2	0.3	0.4	-0.3	0.4	-0.6
Schizophrenia (2014)	0.2	0.4	1.5	-0.2	-1.2	-0.2	0.4
Triglycerides	1.0	1.7	2.7	1.7	-0.9	-1.1	-1.4
Type 2 Diabetes (T2D) (2012)	1.8	2.0	5.6	-0.3	-2.4	-0.2	1.5
Ulcerative Colitis	0.3	0.5	1.0	0.4	-1.0	-0.5	0.7
Blood Eosinophil Count	2.2	16.8	37.8	-6.2	-1.7	-2.0	4.7
Blood Platelet Count	0.1	1.3	3.8	1.9	0.9	-0.4	-0.6
Blood Red Count	0.1	1.3	1.7	-1.1	1.3	-0.9	1.2
Blood White Count	0.2	1.2	3.6	0.8	-0.8	-1.9	0.0
Heel T-Score	0.5	3.9	11.2	1.0	-0.8	-3.3	-1.6
BMI	0.3	1.9	4.3	-1.0	-2.1	-1.2	1.0
Height	0.0	0.6	1.8	-0.1	-0.3	1.4	-0.6
Waist Hip Ratio (WHR)	0.3	1.2	2.5	0.6	1.0	1.6	-0.8
Systolic Blood Pressure	0.5	2.4	5.2	-1.4	-1.4	0.8	2.3
Smoking Status	0.1	0.2	0.7	0.0	0.8	0.3	0.1
Allergy or Eczema	0.4	1.0	2.7	-1.0	1.6	-0.7	-0.2
Cardiovascular Disease	0.7	2.2	3.2	-1.4	-1.8	-1.5	1.1
Hypothyroidism (self reported)	2.6	6.1	18.5	4.3	-0.3	0.0	-2.4
Respiratory disease	0.8	1.8	4.1	0.0	1.1	2.0	1.4
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.1	-1.3	-1.4	-0.8	1.2
Lung FEV1/FVC ratio	0.3	1.7	4.9	-2.2	-1.0	-0.3	1.0
Lung FVC	0.3	1.6	2.2	1.4	1.0	1.5	-1.1
Neuroticism	0.4	0.9	1.9	-0.6	0.3	-1.4	1.1
Chronotype (morning person)	0.5	1.2	2.8	0.3	1.3	1.7	-0.3
Hair Pigment	0.0	0.1	0.3	0.3	0.5	-0.3	0.1
Tanning	0.0	0.5	1.3	-0.1	1.1	-0.7	0.1
Hand grip strength (left)	1.2	3.3	5.6	-2.2	-1.5	0.7	2.4
Number of treatments/medications taken	0.4	0.8	2.1	-0.7	0.1	-1.5	0.6
Average weekly spirits intake	0.7	0.9	3.0	-0.2	-1.7	-0.6	-0.6
Sensitivity / hurt feelings	0.6	1.1	1.7	-1.3	-1.1	-0.9	0.7
Frequency of depressed mood in last 2 weeks	1.8	2.6	7.8	-0.7	2.8	0.7	1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.2	-0.0	0.9	0.5
Relative age of first facial hair	0.1	0.3	1.0	1.0	-0.3	0.3	0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	2.0	1.4	0.3	-0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.5	0.0	1.6	0.1	0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.2	0.5	-0.5	-0.7
Systolic blood pressure, automated reading	0.2	0.5	0.9	-0.1	-0.8	0.9	0.8
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	5.0	1.5	2.2	0.5	-2.0
Angina	0.1	0.2	0.4	-0.7	0.1	-0.5	-0.0
Medication for hormone replacement therapy	0.6	0.6	1.6	-0.4	1.3	0.7	-0.5
Vitamin and mineral supplements	0.4	0.6	1.1	0.1	-1.0	-1.1	-0.4
Supplements: Zinc	0.4	0.5	1.1	1.1	-0.5	-0.1	-0.7
Medication: Co-codamol	1.0	1.2	4.1	0.3	-2.0	0.0	-0.7
Medication: Metformin	1.2	1.6	3.2	-1.4	0.7	-1.8	1.0
Diabetes (father)	0.7	0.9	1.9	-0.4	-0.0	1.4	1.2
Diabetes (mother)	0.3	0.4	1.1	-0.2	-1.1	0.0	0.8
Severe depression (siblings)	0.3	0.3	0.9	0.4	0.9	-0.2	0.2
Pack years adult smoking proportion	0.6	1.0	2.1	-1.4	-0.4	0.1	1.3
Impedance of leg (right)	0.0	0.1	0.3	-0.3	0.5	0.3	0.1
Leg fat-free mass (left)	0.0	0.1	0.2	-0.2	-0.4	-0.4	0.3
Trunk fat percentage	0.3	1.2	1.8	1.1	-1.3	-1.2	-0.7
Hand grip strength (right)	1.7	4.5	8.0	-2.8	-1.1	1.6	2.5
Townsend deprivation index at recruitment	0.5	0.7	1.4	-1.0	0.4	1.2	0.5
Current tobacco smoking	0.7	1.2	2.5	-0.5	-0.9	1.6	1.1
Average weekly fortified wine intake	0.5	0.6	1.6	0.6	1.3	0.6	0.1
Maternal smoking around birth	0.5	0.7	1.5	-0.0	1.2	-0.5	1.0
Fed-up feelings	0.3	0.5	1.3	-0.5	0.5	-1.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.5	0.2	1.9	1.4	0.3
Relative age voice broke	0.2	0.3	0.8	0.1	-0.9	0.5	0.4
Taking other prescription medications	0.4	0.6	1.5	0.6	-1.2	-0.6	0.5
Age when periods started (menarche)	0.2	0.4	0.9	-0.8	0.2	-0.9	0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.0	-0.6	2.0	0.9	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.6	1.0	-1.0	-2.4	-0.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.8	-0.8	-1.2	0.9	1.4
Qualifications: CSEs or equivalent	0.7	1.0	1.5	-1.1	-1.2	-0.2	1.1
Serious illness, injury or assault to yourself	2.3	2.8	6.6	-0.3	-1.0	1.9	2.6
High blood pressure	0.2	0.6	1.6	-0.3	-0.7	-1.2	-0.1
Hayfever, allergic rhinitis or eczema	0.7	1.4	3.6	-1.3	1.9	-0.2	0.7
Multivitamins +/- minerals	0.5	0.6	1.0	-1.0	0.5	0.8	0.7
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.0	-0.4	-0.8	0.1
Supplements: Glucosamine	0.2	0.3	1.0	0.4	-1.0	0.3	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.0	1.0	0.5	0.6	0.3
Medication: Atenolol	0.4	0.4	0.9	-0.8	-0.4	-0.2	0.9
Medication: Levothyroxine sodium	1.8	3.1	10.4	3.2	-0.6	-0.1	-1.3
Sitting height	0.2	1.3	3.3	-1.8	-0.4	-0.2	1.3
Chronic bronchitis/emphysema (father)	0.9	1.0	2.0	0.5	0.1	-1.4	-1.4
High blood pressure (mother)	0.7	1.0	3.5	0.4	-1.9	-0.1	0.7
Body mass index (BMI)	0.2	0.7	1.3	0.8	-0.9	-1.1	-0.5
Impedance of leg (left)	0.0	0.1	0.3	-0.0	0.6	0.1	-0.5
Leg predicted mass (left)	0.0	0.1	0.3	-0.2	-0.5	-0.4	0.3
Trunk fat mass	0.2	0.9	1.5	0.7	-1.2	-1.2	-0.4
Waist circumference	0.3	1.1	1.6	1.1	-0.3	-1.3	-1.3
Number of incorrect matches in round	0.2	0.3	0.7	-0.8	-0.5	-0.6	-0.2
Past tobacco smoking	0.6	1.1	2.2	-0.9	-1.0	0.3	1.5
Alcohol usually taken with meals	0.8	1.2	2.4	-0.3	0.2	1.6	1.5
Nervous feelings	0.1	0.2	0.5	0.1	-0.0	-0.7	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	7.1	-0.4	2.7	0.2	1.9
Hearing difficulty/problems with background noise	0.2	0.4	1.0	0.4	0.3	1.0	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	-1.0	-0.1	-0.2	0.4
Had menopause	0.9	1.1	3.0	1.7	0.7	0.8	-0.5
Had other major operations	0.6	0.8	2.2	-1.5	0.7	-0.3	0.5
Forced vital capacity (FVC)	0.1	0.2	0.5	-0.7	0.1	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.9	0.8	-0.7	-2.2	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.0	1.0	1.4	0.2	0.5
Qualifications: None of the above	1.3	2.8	5.1	1.2	1.4	-1.7	-2.2
Financial difficulties in last 2 years	0.4	0.6	1.2	0.6	-0.7	1.1	-0.5
Mouth/teeth dental problems	0.7	1.0	3.1	-0.4	-0.5	1.8	0.8
Heart attack	0.1	0.1	0.5	-0.2	-0.0	-0.7	-0.0
Allergy	0.3	0.6	1.8	-0.1	-1.4	0.7	0.0
Pain all over the body in last month	1.0	1.1	3.0	1.7	-0.1	0.9	-0.6
Diabetes (self-reported)	0.6	0.9	1.8	-1.3	0.4	-1.0	0.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	5.9	-2.4	0.3	0.8	0.6
Medication: Ramipril	1.0	1.3	3.8	-0.9	-2.0	-0.5	0.7
Medication: Simvastatin	0.5	0.8	1.5	-0.6	1.1	-1.2	0.1
Fluid intelligence score	0.5	1.0	2.8	1.7	0.0	1.0	0.1
Illnesses of siblings	0.4	0.6	1.6	-1.3	0.0	0.2	-0.8
Neuroticism score	0.5	1.0	2.6	-0.0	0.9	-1.6	0.7
Weight	0.1	0.3	0.6	0.2	-0.8	-0.8	-0.3
Impedance of arm (right)	0.1	0.5	1.3	-0.0	-0.1	1.2	0.7
Arm fat percentage (right)	0.2	0.8	1.9	0.8	-1.4	-0.9	-0.1
Trunk fat-free mass	0.1	0.4	1.2	-1.1	0.0	-0.3	0.7
Hip circumference	0.3	1.1	2.1	0.7	-1.1	-1.4	-0.9
Time employed in main current job	0.4	0.4	0.8	0.8	0.0	0.5	-0.9
Alcohol intake versus 10 years previously	0.6	1.0	1.7	-1.3	-0.5	1.0	0.9
Father’s age at death	1.1	1.5	4.3	0.5	1.0	0.6	-2.1
Worrier / anxious feelings	1.6	3.0	6.0	-1.8	0.5	-1.6	2.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.1	0.0	1.8	-0.5	0.4
Falls in the last year	0.6	0.8	1.3	0.7	0.5	-1.0	-1.1
Hair/balding pattern: Pattern 3	0.3	0.4	0.7	0.8	0.9	-0.1	-0.6
Number of live births	1.0	1.4	2.1	0.8	-1.5	-1.2	-1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.2	-1.1	-0.4	0.6	0.7
Pulse rate	1.1	1.9	5.8	0.2	2.4	-0.8	-1.0
Happiness	0.9	1.1	2.8	-0.2	1.7	1.0	0.7
Noisy workplace	2.3	2.9	5.4	-2.3	1.1	1.3	1.8
Qualifications: A levels/AS levels or equivalent	0.9	2.1	5.2	1.7	0.0	2.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.4	-0.6	-0.1	-0.3
Mouth/teeth dental problems: Dentures	1.8	3.0	5.0	2.2	0.1	-2.1	-1.6
Asthma	0.5	1.1	3.1	0.1	1.8	0.6	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	-0.7	-0.5	-0.5	0.7
Medication: Cholesterol lowering	0.6	1.0	2.9	-1.7	-0.1	-0.8	0.6
Depression (self-reported)	1.8	2.2	3.9	1.8	0.2	-2.0	-1.3
Medication: Lansoprazole	0.6	0.7	1.5	1.2	0.2	0.0	-1.1
Prospective memory result	0.2	0.2	0.4	-0.7	0.5	0.2	0.4
Lung cancer (father)	0.1	0.1	0.2	0.2	0.1	-0.2	-0.4
Illnesses of mother	0.8	1.0	2.2	-0.3	1.3	0.2	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	-0.8	0.3	0.4	0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.6	-0.3	-0.1	0.3
Impedance of arm (left)	0.1	0.6	1.6	-0.4	-0.5	1.3	0.8
Arm fat mass (right)	0.2	0.7	1.3	0.5	-1.1	-1.1	-0.5
Trunk predicted mass	0.1	0.5	1.3	-1.1	0.0	-0.2	0.7
Standing height	0.1	0.8	2.4	-1.6	0.1	0.6	0.5
Length of working week for main job	1.8	2.0	3.8	-1.2	1.9	1.7	-0.0
Exposure to tobacco smoke at home	4.5	5.0	11.2	1.7	2.4	0.5	-3.3
Breastfed as a baby	0.9	1.1	3.4	0.4	0.9	0.2	-1.8
Tense / ‘highly strung’	0.6	1.0	2.9	-0.8	0.3	-0.7	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.1	0.7	0.4	-2.0	0.0
Hair/balding pattern: Pattern 4	1.4	3.4	7.3	-1.6	-1.5	1.2	2.7
Birth weight of first child	1.2	2.2	3.2	-1.7	-1.8	-0.5	1.5
Peak expiratory flow (PEF)	0.5	1.1	2.0	-1.2	-0.1	1.4	1.0
Pulse wave reflection index	0.5	0.6	1.3	-0.5	-1.1	0.7	0.6
Ever highly irritable/argumentative for 2 days	1.8	2.1	4.2	2.1	0.1	-1.5	-1.4
Loud music exposure frequency	1.4	1.5	2.0	-0.5	1.3	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.7	-0.7	-0.4	1.0	1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.8	0.0	0.7	-1.3	-0.8
Blood clot in the leg (DVT)	1.0	1.3	2.3	0.8	-0.8	-1.5	-1.2
Medication: Paracetamol	0.7	1.2	2.6	-1.2	0.9	-1.6	-0.2
Headache pain in last month	0.6	1.0	2.8	0.3	1.7	-0.9	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.8	0.6	0.6	1.3	-0.1
Glaucoma (self-reported)	2.3	2.7	4.8	-0.9	-2.2	-1.7	1.6
Gout (self-reported)	4.6	6.4	11.3	-2.5	-3.4	-0.3	2.8
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	16.4	4.1	0.3	0.2	-1.8
Medication: Amlodipine	0.5	0.7	1.7	-0.7	-1.3	0.3	0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	1.1	0.9	0.0	0.2
Birth weight	0.6	1.4	3.0	0.3	-1.7	-1.4	0.8
Chronic bronchitis/emphysema (mother)	1.0	1.2	4.0	0.8	2.0	0.1	-0.0
High blood pressure (siblings)	0.3	0.5	1.7	0.3	-0.3	-0.3	1.3
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	-0.8	0.2	0.1	0.6
Body fat percentage	0.3	1.1	1.4	1.2	-1.1	-1.1	-0.7
Leg fat percentage (right)	0.2	0.8	1.4	1.2	-0.9	-0.9	-0.5
Arm fat-free mass (right)	0.0	0.2	0.5	-0.7	-0.0	-0.6	-0.0
Exposure to tobacco smoke outside home	0.3	0.3	1.0	-0.0	1.0	-0.6	-0.3
Comparative body size at age 10	0.5	1.4	2.5	1.5	-0.8	-0.2	-1.6
Number of full brothers	0.2	0.2	0.5	0.4	-0.7	-0.2	-0.3
Worry too long after embarrassment	0.7	1.2	3.5	-0.6	0.1	0.9	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	1.0	0.6	-0.4	0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.4	0.2	0.2	0.6
Number of children fathered	0.7	0.8	1.8	-1.3	-0.8	-0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.1	-1.5	-0.5	1.0	1.8
Age at first live birth	1.8	3.2	9.2	-0.8	1.5	3.0	0.8
Pulse wave peak to peak time	0.1	0.1	0.2	0.5	0.2	0.2	-0.3
Health satisfaction	0.3	0.4	1.3	0.1	0.2	-0.5	1.1
Shortness of breath walking on level ground	0.3	0.4	0.8	0.9	0.1	0.1	0.9
Qualifications: College or University degree	0.0	0.0	0.1	0.0	-0.0	-0.3	-0.0
Eye problems/disorders: None of the above	1.1	1.3	1.8	-1.1	1.3	-1.2	0.8
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.5	1.3	1.6	-0.8	-1.2
Emphysema/chronic bronchitis	0.8	0.8	1.4	1.0	0.6	-1.2	-0.9
Medication for pain relief, constipation, heartburn	0.8	1.4	4.5	0.8	-0.5	2.1	0.2
Neck or shoulder pain in last month	1.4	2.0	4.1	-0.5	-1.6	-2.0	-1.1
Medication: Blood pressure	0.2	0.3	1.2	0.0	-0.3	-1.1	-0.0
Angina (self-reported)	0.2	0.2	0.5	-0.7	0.2	-0.6	0.1
Migraine (self-reported)	1.7	2.1	5.2	1.2	2.3	0.3	-1.3
Medication: Ibuprofen	0.8	1.0	2.2	-1.0	-0.2	-1.5	0.8
Medication: Allopurinol	2.5	3.3	8.9	-0.8	-3.0	-0.8	1.8
Medication: Omeprazole	0.2	0.2	0.6	0.3	-0.8	-0.3	0.2
Medication: Seretide 50 evohaler	1.3	1.5	3.1	1.8	1.0	1.2	-0.5
Mean time to correctly identify matches	0.2	0.4	1.0	1.0	-0.1	-0.2	-0.7
Heart disease (mother)	0.7	0.8	1.6	1.0	-0.7	-1.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.6	0.2	0.4	0.7
Whole body fat mass	0.2	0.7	1.2	0.5	-1.0	-1.1	-0.5
Leg fat mass (right)	0.2	0.8	1.4	0.8	-0.8	-1.2	-0.7
Arm predicted mass (right)	0.0	0.2	0.4	-0.6	-0.1	-0.4	-0.0
Pulse rate, automated reading	0.7	2.3	8.1	-0.9	2.8	0.0	0.4
Alcohol intake frequency.	0.1	0.2	0.5	-0.4	0.3	-0.7	0.0
Comparative height size at age 10	0.3	1.8	3.4	-1.8	-0.1	1.2	1.5
Number of full sisters	0.8	1.0	1.4	-1.0	0.0	-1.2	1.2
Suffer from ‘nerves’	0.3	0.5	1.5	-0.5	0.7	-0.1	1.2
Overall health rating	0.8	1.7	5.2	2.3	0.8	-0.6	-0.8
Chest pain or discomfort	0.4	0.5	1.0	0.8	-0.6	-1.0	0.1
Had major operations	0.7	0.8	1.7	0.7	-0.6	-1.3	-0.8
Age at last live birth	1.8	2.6	8.6	-0.9	0.5	2.9	0.8
Family relationship satisfaction	2.7	3.3	9.7	0.7	3.1	-1.4	-1.0
Leg pain on walking	0.4	0.6	2.2	0.1	1.5	0.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.7	-0.8	-0.1	1.3	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	-0.0	-0.9	0.9	0.8
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.3	-0.7	1.1	-1.5	-0.6
Medication: Aspirin	0.8	1.1	4.3	-0.1	-0.0	-2.1	-0.0
Supplements: Vitamin C	0.8	0.9	2.5	1.1	0.2	1.6	0.0
Knee pain experienced in last month	0.4	0.6	1.9	0.3	0.2	-1.4	-0.5
Hypertension (Self-reported)	0.2	0.6	1.5	-0.7	-0.6	-1.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.1	1.5	-0.2	-1.0	-1.3
Illnesses of father: Heart disease	0.3	0.5	1.1	0.1	-0.9	1.1	-0.1
Illnesses of siblings: Diabetes	0.7	0.8	1.8	1.2	0.0	1.3	-0.2
Smoking status: Previous	1.6	2.5	3.6	1.3	1.6	-1.4	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.0	0.3	0.0	-0.3
Whole body fat-free mass	0.0	0.2	0.6	-0.8	-0.1	-0.3	0.4
Leg fat-free mass (right)	0.0	0.1	0.2	-0.1	-0.5	-0.3	0.1
Arm fat percentage (left)	0.2	0.8	2.0	0.7	-1.4	-0.8	-0.1
Average weekly red wine intake	0.1	0.1	0.4	0.0	0.1	-0.0	0.7
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.4	-0.4	-0.5	0.1
Mood swings	0.4	0.7	1.1	-1.0	0.5	-1.1	0.7
Loneliness, isolation	1.3	1.8	7.1	0.2	2.7	-0.4	-0.0
Long-standing illness, disability or infirmity	0.8	1.3	2.4	1.3	1.6	-0.4	-0.9
Ever had bowel cancer screening	0.9	1.0	1.7	0.6	0.9	-1.1	-1.3
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.3	0.2	-0.7	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.2	-0.1	-0.3	1.1	0.4
Friendships satisfaction	1.2	1.4	4.7	0.8	2.2	0.7	0.1
Qualifications: nursing, teaching	0.2	0.3	1.1	-0.0	-0.3	1.0	-0.2
Commuting to job workplace: Walk	0.8	0.9	2.4	-0.4	0.2	-1.6	-1.0
Eye problems/disorders: Cataract	1.4	1.6	2.8	1.1	-1.7	0.9	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.3	-1.4	-0.4	1.0	1.5
Medication for cholesterol	0.3	0.4	1.0	-0.2	-0.2	1.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	-0.6	-0.3	-1.1	1.0
Back pain experienced in last month	0.1	0.2	0.6	-0.2	0.3	-0.8	-0.4
Mineral and other dietary supplements	0.2	0.2	0.4	0.5	0.5	0.1	-0.6
Breast cancer (self-reported)	0.4	0.5	0.7	0.4	-0.8	0.8	0.8
Asthma (self-reported)	0.7	1.4	4.0	-0.3	2.0	0.7	1.1
Osteoporosis (self-reported)	0.9	1.2	2.6	-1.0	0.7	-1.6	0.7
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.3
Medication: Aspirin	1.1	1.5	5.6	-0.4	-0.3	-2.4	-0.2
Medication: Gliclazide	0.2	0.2	0.5	-0.7	0.0	-0.3	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	0.9	-0.2	-0.4	0.0
Smoking status: Current	1.2	2.0	4.3	-0.8	-0.8	2.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.7	-1.6	0.1	-0.4	0.4
Whole body water mass	0.0	0.2	0.4	-0.7	-0.1	-0.3	0.2
Leg predicted mass (right)	0.0	0.1	0.3	-0.1	-0.5	-0.4	0.0
Arm fat mass (left)	0.1	0.6	1.4	0.3	-1.2	-0.9	-0.2
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	0.4	-0.1	-1.0	-0.5
Average weekly champagne plus white wine intake	0.6	0.8	1.8	-1.3	-1.0	0.2	0.7
Miserableness	0.1	0.2	0.3	-0.6	0.2	-0.2	0.5
Guilty feelings	0.7	1.1	2.1	1.4	0.0	-1.3	-0.8
Wears glasses or contact lenses	0.3	0.4	0.8	0.4	-0.6	-0.9	0.5
Ever taken oral contraceptive pill	0.5	0.6	1.0	-0.7	-0.7	-1.0	0.6
Hearing aid user	1.9	2.1	5.7	-0.9	-2.4	-1.2	0.8
Mother’s age at death	1.6	2.0	3.9	-1.0	-1.4	1.0	2.0
Financial situation satisfaction	1.1	1.4	2.8	-1.2	0.1	1.2	1.7
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.6	-1.3	0.2	0.0	-0.3
Commuting to job workplace: Public transport	2.0	2.4	5.4	0.8	1.0	-2.3	-1.6
Eye problems/disorders: Glaucoma	1.5	1.8	3.1	-1.0	-1.7	-0.9	1.6
Medication: Blood pressure	0.7	1.3	2.6	-1.6	-0.9	0.1	1.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.1	0.4	-1.2	-1.8	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.7	-0.5	-1.0	0.1
High cholesterol (Self-reported)	0.3	0.5	1.6	-0.2	0.4	-1.3	0.1
Medication: Bendroflumethiazide	0.6	1.0	2.2	-1.2	-1.5	-0.5	0.2
Medication: Paracetamol	1.0	1.5	4.2	-1.3	0.0	-2.0	-0.2
Medication: Lisinopril	1.4	1.8	5.0	-2.2	-0.5	-0.9	1.1
Medication: Atorvastatin	0.4	0.4	1.3	-0.4	-0.5	1.2	-0.0
Illnesses of father: High blood pressure	2.5	3.1	7.8	-2.8	0.1	-0.0	2.1
Alcohol drinker status: Never	0.6	0.7	1.8	0.5	-0.5	-0.9	-1.3
Ever smoked	0.2	0.3	0.6	-0.0	0.8	0.5	-0.7
Basal metabolic rate	0.0	0.2	0.3	-0.6	-0.3	-0.5	0.3
Leg fat percentage (left)	0.3	1.0	1.6	1.2	-0.9	-1.0	-0.7
Arm fat-free mass (left)	0.0	0.2	0.4	-0.7	0.4	-0.3	0.1
Number of operations (self-reported)	0.5	0.8	2.2	0.5	0.3	-1.5	-0.7
Average weekly beer plus cider intake	1.0	1.4	2.5	0.8	0.3	-1.6	-1.6
Irritability	0.4	0.7	1.7	0.6	0.8	-1.3	0.2
Risk taking	0.2	0.4	0.8	0.9	0.8	-0.1	-0.1
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.7	0.7	-1.2	-1.6	-0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.3	-0.5	0.3	-0.2
Age started oral contraceptive pill	0.3	0.4	0.6	-0.5	0.7	0.5	-0.6
Diastolic blood pressure, automated reading	0.5	1.6	3.6	-0.4	-0.9	1.3	1.9
Ever depressed for a whole week	1.2	1.5	4.9	-0.1	-0.7	0.8	2.2
Unable to work because of sickness or disability	0.4	0.5	1.5	-0.2	-0.6	-1.2	-0.0
Commuting to job workplace: Cycle	1.3	1.5	3.1	1.5	0.3	0.8	-1.8
Myopia	0.7	0.9	2.0	1.4	0.6	0.4	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.0	0.0	0.9	1.4	0.1
Cholesterol lowering medication	0.4	0.6	1.2	1.0	1.1	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	-0.1	0.2	-0.4
Pain experienced in last month	0.6	1.0	1.3	-1.2	-0.9	1.0	0.9
Supplements: Calcium	1.8	2.0	2.8	-1.1	1.7	1.2	1.6
Basal cell carcinoma (self-reported)	0.7	0.8	1.4	-0.4	0.9	1.2	0.9
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.5	-0.1	0.0	-0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.1	0.5	-0.8	-1.0	-1.0
Heart disease (siblings)	0.7	0.9	3.3	1.8	0.5	-0.0	0.0
Alcohol drinker status: Previous	0.7	0.8	1.9	0.1	1.1	-1.4	0.4
Pack years of smoking	0.5	0.8	1.8	-1.3	-0.4	0.1	1.0
Impedance of whole body	0.0	0.2	0.7	0.1	0.1	0.8	0.0
Leg fat mass (left)	0.2	0.8	1.2	0.8	-0.9	-1.1	-0.7
Arm predicted mass (left)	0.0	0.2	0.4	-0.4	0.3	-0.6	-0.2