Hub : Genes

PIK3R5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.0841	0.0327	4.4e-03	0.002	NA	-0.003	NA	-0.003	1.9e-01	NA	8.6e-01	NA	8.9e-01
2	GTEx	Testis	0.4220	0.0740	1.8e-07	0.399	NA	0.381	NA	0.402	6.1e-19	NA	5.6e-18	NA	3.9e-19
3	GTEx	Vagina	0.4830	0.1250	2.4e-03	0.012	NA	0.002	NA	0.008	1.7e-01	NA	2.8e-01	NA	2.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	3.0	-1.7	-0.3	0.9
Bipolar Disorder or Schizophrenia	1.2	2.9	8.5	-2.9	-0.5	-0.1
Depressed Affect (Nagel 2018)	0.8	1.7	3.8	-0.9	-1.9	0.6
Depression (Nagel 2018)	1.7	2.6	4.1	-0.5	-1.9	2.0
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.0	2.0	0.1	1.9
Neuroticism (Nagel 2018)	0.8	1.8	3.9	-0.5	-1.1	2.0
Schizophrenia (2018)	1.0	2.0	5.1	-2.3	-0.5	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	0.5	-1.1	-0.6
Worry (Nagel 2018)	0.4	0.8	2.3	-0.2	0.1	1.5
Alzheimer’s Disease (in mother)	0.9	1.0	2.6	0.5	1.6	-0.6
Alzheimer’s Disease (in father)	1.5	1.7	3.3	-1.2	-1.8	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.2	0.3	0.3
Crohns Disease (2017)	0.8	1.7	2.6	1.3	0.8	1.6
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	1.0	0.3	-0.0
Ulcerative Colitis (UC)	0.5	0.9	1.9	0.6	-0.7	-1.4
Major Depression (MDD)	0.4	0.5	1.5	1.2	-0.1	0.3
Reaction Time	0.1	0.1	0.2	0.0	-0.4	0.5
Verbal and Numeric Reasoning (VNR)	1.2	2.8	6.3	1.4	-0.1	2.5
Breast Cancer	0.1	0.2	0.3	0.0	0.6	-0.6
Ovarian Cancer	0.9	1.2	2.5	1.6	1.0	0.1
Prostate Cancer	0.7	1.0	1.5	1.2	-1.1	-0.5
Age at First Birth	0.4	0.6	1.0	-0.9	-1.0	0.1
Bipolar Disorder (2011)	1.7	1.6	3.5	-1.1	-0.5	1.9
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	0.3	-0.9	-0.7
Coronary Artery Disease (CAD)	0.9	1.1	2.4	-1.6	-0.0	0.9
Crohns Disease (2012)	2.7	4.3	11.8	1.0	-0.3	3.4
Mean Putamen Volume	0.3	0.4	0.5	0.6	0.7	-0.5
Fasting Glucose	1.5	1.8	4.4	-0.2	-2.1	0.9
HbA1C	1.8	2.0	4.2	-2.0	1.2	-0.6
HDL Cholesterol	0.1	0.2	0.6	0.7	0.0	0.1
LDL Cholesterol	0.5	0.9	1.7	-0.1	-1.3	-0.9
Lupus	0.1	0.2	0.3	-0.5	0.1	-0.5
Neuroticism (2016)	1.1	1.7	2.0	-1.4	-1.1	1.3
Primary Biliary Cirrhosis	1.2	1.7	4.1	-0.9	0.4	2.0
Rheumatoid Arthritis	0.7	0.9	1.8	-0.7	-1.3	0.7
Schizophrenia (2014)	1.0	2.1	5.0	-2.2	-0.7	-0.9
Triglycerides	0.2	0.3	0.4	-0.6	-0.3	-0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.3	0.1	-0.5
Ulcerative Colitis	0.0	0.1	0.2	-0.2	-0.1	-0.4
Blood Eosinophil Count	2.2	17.3	34.8	-0.7	5.9	-4.1
Blood Platelet Count	0.2	2.3	5.2	1.2	-2.3	0.4
Blood Red Count	0.1	1.3	2.8	1.7	0.9	-0.7
Blood White Count	0.3	2.0	3.9	1.3	0.6	-2.0
Heel T-Score	0.1	1.1	2.7	1.6	-0.5	0.6
BMI	0.2	1.4	3.3	0.5	0.7	-1.8
Height	0.0	0.5	1.3	0.3	1.2	-0.4
Waist Hip Ratio (WHR)	0.2	1.0	1.4	-0.7	-1.2	-1.0
Systolic Blood Pressure	0.1	0.7	1.8	1.3	0.3	0.5
Smoking Status	0.5	1.1	3.1	1.8	-0.6	0.1
Allergy or Eczema	0.4	1.1	2.0	-0.7	-1.0	1.4
Cardiovascular Disease	0.7	2.2	2.8	1.3	1.7	-1.5
Hypothyroidism (self reported)	3.0	6.8	10.3	-1.2	-2.9	3.2
Respiratory disease	0.3	0.7	1.0	1.0	-1.0	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	1.1	0.6	-0.0
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.2	0.6	-0.7
Lung FVC	0.5	2.4	4.7	-1.2	-1.1	2.2
Neuroticism	0.7	1.6	2.5	-1.1	-1.0	1.6
Chronotype (morning person)	0.6	1.3	1.9	-0.9	-1.4	1.1
Hair Pigment	0.0	1.1	1.8	1.0	-1.4	0.7
Tanning	0.2	2.7	7.4	-0.2	-0.8	-2.7
Hand grip strength (left)	0.8	2.2	3.5	-1.9	1.7	-0.6
Number of treatments/medications taken	0.3	0.5	1.1	0.2	-1.0	-0.5
Average weekly spirits intake	0.4	0.5	1.1	0.2	1.1	-0.5
Sensitivity / hurt feelings	1.6	2.7	5.4	-1.6	0.0	2.3
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.0	-0.0	-1.7	0.8
Hearing difficulty/problems: Yes	0.6	0.9	2.0	-1.4	-0.5	0.7
Relative age of first facial hair	0.6	1.3	3.6	-1.9	-0.2	0.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.2	-1.3	-1.5	0.1
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.8	2.0	-1.0	0.4
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	0.2	-0.5	-1.6
Systolic blood pressure, automated reading	0.5	1.5	2.5	1.4	0.3	1.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	1.3	-0.1	0.6
Angina	0.2	0.3	0.5	0.7	-0.3	-0.6
Medication for hormone replacement therapy	1.2	1.3	2.2	1.5	-1.1	0.8
Vitamin and mineral supplements	0.7	1.0	2.6	-1.6	0.1	0.6
Supplements: Zinc	1.0	1.1	1.4	1.0	1.2	0.9
Medication: Co-codamol	0.6	0.7	1.3	-0.8	-1.1	-0.5
Medication: Metformin	0.9	1.3	2.3	1.5	-0.1	-1.2
Diabetes (father)	0.5	0.6	1.2	0.5	0.5	1.1
Diabetes (mother)	2.2	2.8	6.2	2.5	-1.5	-0.4
Severe depression (siblings)	2.3	2.5	2.9	1.4	-1.6	1.7
Pack years adult smoking proportion	0.4	0.6	1.0	-0.1	1.0	-0.8
Impedance of leg (right)	0.1	0.5	1.4	-0.4	-0.0	1.2
Leg fat-free mass (left)	0.3	1.6	4.2	0.8	0.1	-2.0
Trunk fat percentage	0.2	1.0	2.3	0.7	-1.5	-0.4
Hand grip strength (right)	0.3	0.9	1.1	-0.9	0.9	-1.1
Townsend deprivation index at recruitment	0.3	0.4	1.0	-0.2	-0.1	-1.0
Current tobacco smoking	0.3	0.5	0.7	-0.4	0.8	-0.7
Average weekly fortified wine intake	0.3	0.3	0.6	-0.8	0.4	-0.5
Maternal smoking around birth	0.4	0.6	1.3	1.1	0.0	-0.6
Fed-up feelings	0.5	0.8	1.4	-1.2	-1.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.8	-0.7	-1.3	0.3
Relative age voice broke	0.7	1.1	2.2	-1.5	0.6	-0.9
Taking other prescription medications	0.5	0.7	1.4	-1.2	-0.8	-0.4
Age when periods started (menarche)	0.5	1.2	2.3	-0.2	1.1	-1.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.9	-0.2	-0.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.3	1.0	-0.3	1.1
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	5.1	-0.9	2.3	-0.9
Qualifications: CSEs or equivalent	0.7	0.9	1.2	-1.1	0.7	-1.0
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-1.2	-0.0	-0.4
High blood pressure	0.6	1.7	3.2	1.8	0.3	-1.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.7	-0.2	0.1
Multivitamins +/- minerals	0.3	0.4	0.5	0.7	0.3	-0.7
Stomach or abdominal pain in last month	0.8	1.0	2.9	-0.5	-0.1	-1.7
Supplements: Glucosamine	1.0	1.3	3.6	-0.2	-1.9	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	-0.4	-0.8	0.1
Medication: Atenolol	0.7	0.9	2.4	-0.6	1.6	-0.0
Medication: Levothyroxine sodium	2.1	3.6	4.8	-1.4	-1.9	2.2
Sitting height	0.1	0.9	1.1	0.9	1.1	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.1	-0.7	-0.4
High blood pressure (mother)	0.5	0.7	1.9	0.3	-1.4	-0.4
Body mass index (BMI)	0.1	0.5	0.7	0.2	-0.9	-0.9
Impedance of leg (left)	0.1	0.7	1.8	-0.6	-0.2	1.3
Leg predicted mass (left)	0.3	1.7	4.2	0.9	0.1	-2.1
Trunk fat mass	0.2	0.7	1.0	0.6	-1.0	-0.9
Waist circumference	0.5	1.9	4.2	0.5	-1.1	-2.0
Number of incorrect matches in round	0.5	0.8	2.0	0.4	1.4	-0.5
Past tobacco smoking	1.7	3.1	6.1	-2.5	1.7	-0.7
Alcohol usually taken with meals	0.4	0.7	1.1	1.1	-0.3	0.9
Nervous feelings	0.7	1.4	3.3	0.7	0.6	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	-0.2	-0.9	-0.6
Hearing difficulty/problems with background noise	2.2	3.6	10.4	-3.2	0.6	-0.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.5	-0.6	-0.4	-1.2
Had menopause	0.6	0.8	1.9	1.4	-0.6	0.2
Had other major operations	2.5	3.1	6.3	1.6	0.7	-2.5
Forced vital capacity (FVC)	0.1	0.3	0.4	-0.5	0.5	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	0.9	0.2	1.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	0.0	-0.0	-0.2
Qualifications: None of the above	0.5	1.0	2.9	0.2	-1.7	-0.2
Financial difficulties in last 2 years	1.1	1.5	1.7	-1.3	-1.3	1.1
Mouth/teeth dental problems	0.6	1.0	1.7	-1.3	-0.9	0.5
Heart attack	0.0	0.0	0.1	-0.2	-0.2	-0.2
Allergy	0.6	1.4	4.0	0.3	2.0	0.1
Pain all over the body in last month	0.6	0.6	1.7	0.3	-0.3	1.3
Diabetes (self-reported)	0.7	1.1	3.1	1.8	-0.5	0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	0.2	1.3	0.1
Medication: Ramipril	0.4	0.5	1.3	0.5	1.1	0.1
Medication: Simvastatin	0.5	0.8	2.2	0.5	-1.5	0.1
Fluid intelligence score	2.0	4.2	12.0	0.8	0.0	3.5
Illnesses of siblings	0.9	1.3	2.4	-1.1	1.5	0.5
Neuroticism score	0.8	1.6	1.9	-1.4	-1.1	1.3
Weight	0.2	0.9	2.6	0.3	-0.1	-1.6
Impedance of arm (right)	0.1	0.3	0.5	-0.1	-0.7	0.6
Arm fat percentage (right)	0.1	0.5	1.4	0.1	-1.2	-0.2
Trunk fat-free mass	0.3	1.7	3.7	0.2	1.1	-1.9
Hip circumference	0.2	0.7	1.5	0.7	0.5	-1.2
Time employed in main current job	0.7	0.8	2.0	-1.4	0.1	0.7
Alcohol intake versus 10 years previously	0.6	0.9	1.4	-0.8	-0.8	-1.2
Father’s age at death	1.1	1.5	2.1	-0.9	-1.3	1.4
Worrier / anxious feelings	0.6	1.1	2.7	1.6	-0.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	5.3	-2.3	-1.3	0.8
Falls in the last year	0.9	1.3	2.1	-1.3	0.4	-1.4
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	0.7	-0.4	-1.2
Number of live births	0.7	0.9	1.8	0.7	1.3	-0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.4	-0.6	0.4	-0.6
Pulse rate	0.2	0.3	0.7	-0.4	-0.4	-0.8
Happiness	0.7	0.9	1.6	-1.0	-1.3	0.0
Noisy workplace	2.2	2.7	8.0	-0.2	0.3	-2.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	0.1	0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	1.4	0.0	-0.1
Mouth/teeth dental problems: Dentures	1.0	1.7	3.8	2.0	-1.1	0.3
Asthma	1.8	3.6	4.4	2.1	-1.5	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.3	0.4	1.1	-0.8
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.1	0.0	-0.5
Depression (self-reported)	2.1	2.5	5.5	1.0	-0.9	2.4
Medication: Lansoprazole	1.2	1.4	2.2	-0.9	-1.1	1.5
Prospective memory result	0.7	0.9	1.7	-0.8	0.3	-1.3
Lung cancer (father)	0.6	0.7	1.9	0.4	-0.1	-1.4
Illnesses of mother	0.5	0.7	1.2	1.1	0.9	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	-0.8	0.2	-0.2
Pulse wave Arterial Stiffness index	1.1	1.3	1.6	1.2	-0.9	1.2
Impedance of arm (left)	0.0	0.2	0.3	0.0	-0.5	0.5
Arm fat mass (right)	0.1	0.4	0.7	0.3	-0.9	-0.7
Trunk predicted mass	0.3	1.6	3.4	0.2	1.1	-1.8
Standing height	0.2	1.8	3.1	0.3	1.4	-1.8
Length of working week for main job	0.4	0.5	0.9	0.2	0.7	-0.9
Exposure to tobacco smoke at home	1.3	1.4	2.0	1.3	-1.4	0.8
Breastfed as a baby	1.1	1.4	2.2	-1.5	1.3	-0.4
Tense / ‘highly strung’	0.3	0.6	0.9	0.5	0.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	0.9	-1.0	-0.4
Hair/balding pattern: Pattern 4	0.5	1.1	3.0	0.0	1.7	-0.6
Birth weight of first child	0.3	0.6	1.6	0.0	1.3	-0.4
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.1	-0.5	0.4
Pulse wave reflection index	0.3	0.3	0.9	0.1	0.2	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	0.1	-1.4	-0.3
Loud music exposure frequency	0.7	0.7	2.0	-0.3	-1.4	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	-0.3	1.4	0.1
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.5	2.1	0.7	0.3
Blood clot in the leg (DVT)	1.3	1.7	3.5	1.1	-1.9	-0.6
Medication: Paracetamol	0.5	0.8	1.9	-1.4	0.6	-0.4
Headache pain in last month	0.4	0.6	1.8	-0.2	-1.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.3	-0.1	-0.1
Glaucoma (self-reported)	1.1	1.3	2.4	-0.2	1.2	-1.6
Gout (self-reported)	2.6	3.6	7.6	-0.2	1.7	-2.8
Hypothyroidism/myxoedema (self-reported)	3.0	5.8	9.4	-0.9	-3.1	2.7
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.1	-0.7
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.6	0.0	-1.9	1.0
Birth weight	0.5	1.0	2.0	-0.3	0.9	-1.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.3	-0.2	0.5
High blood pressure (siblings)	1.2	1.7	5.1	2.2	-0.2	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	1.4	-1.2	0.9	-0.3
Body fat percentage	0.2	0.9	2.5	0.4	-1.6	0.1
Leg fat percentage (right)	0.2	0.7	1.7	0.1	-1.3	0.7
Arm fat-free mass (right)	0.3	1.5	3.3	0.9	0.5	-1.8
Exposure to tobacco smoke outside home	0.7	0.9	1.7	-0.2	-1.0	1.3
Comparative body size at age 10	0.5	1.4	4.3	2.1	-0.1	0.0
Number of full brothers	0.7	0.9	2.3	-1.5	-0.7	0.1
Worry too long after embarrassment	0.7	1.2	3.1	-0.7	0.3	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.3	0.7	-1.1	1.1
Wheeze or whistling in the chest in last year	0.5	0.9	2.7	-0.2	-1.6	-0.3
Number of children fathered	1.6	1.8	3.1	1.8	-0.8	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	5.2	2.3	0.6	0.3
Age at first live birth	0.1	0.1	0.4	0.1	0.0	0.6
Pulse wave peak to peak time	1.0	1.2	1.6	-1.3	1.0	-1.1
Health satisfaction	0.7	0.9	2.0	-1.4	0.3	-0.7
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.3	0.0	-0.8
Qualifications: College or University degree	0.1	0.2	0.3	0.6	0.4	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.4	0.1	1.2	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.4	-0.4	0.7
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.2	-0.5	-0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.2	-0.4	0.5
Neck or shoulder pain in last month	0.6	0.9	2.2	-1.5	-0.1	0.5
Medication: Blood pressure	0.2	0.3	0.8	-0.3	0.0	-0.9
Angina (self-reported)	0.3	0.4	0.6	0.8	-0.6	-0.5
Migraine (self-reported)	0.0	0.1	0.1	-0.2	-0.3	0.3
Medication: Ibuprofen	1.4	1.6	4.3	0.1	0.8	-2.1
Medication: Allopurinol	2.4	3.1	7.1	-1.0	1.2	-2.7
Medication: Omeprazole	0.5	0.5	1.5	1.2	-0.2	-0.2
Medication: Seretide 50 evohaler	4.4	5.0	7.2	2.7	-2.0	2.0
Mean time to correctly identify matches	0.1	0.2	0.4	0.1	-0.6	-0.4
Heart disease (mother)	0.5	0.7	1.1	-1.1	-0.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.3	-0.1	-0.3
Whole body fat mass	0.2	0.6	1.0	0.6	-1.0	-0.7
Leg fat mass (right)	0.1	0.4	1.0	0.5	-1.0	-0.3
Arm predicted mass (right)	0.2	1.3	2.9	0.6	0.7	-1.7
Pulse rate, automated reading	0.2	0.6	1.7	-0.5	-0.1	-1.3
Alcohol intake frequency.	0.7	1.6	4.5	-0.1	-2.1	-0.6
Comparative height size at age 10	0.1	0.6	1.3	-0.5	1.1	-0.5
Number of full sisters	0.4	0.5	0.9	0.3	0.8	-0.9
Suffer from ‘nerves’	0.2	0.3	0.7	0.2	0.8	0.4
Overall health rating	0.4	0.9	1.4	-1.0	-1.2	0.4
Chest pain or discomfort	0.8	1.1	1.8	1.4	0.7	-1.1
Had major operations	0.7	0.9	1.4	1.1	-1.2	0.2
Age at last live birth	0.1	0.2	0.3	0.6	-0.1	0.5
Family relationship satisfaction	0.7	0.9	1.2	-0.8	-1.1	-0.9
Leg pain on walking	0.4	0.5	0.9	0.1	-0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.2	-1.8	-0.0	-0.6
Commuting to job workplace: Car/motor vehicle	2.6	3.0	6.7	1.4	0.5	2.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	-0.2	1.3	-1.8
Medication: Aspirin	0.3	0.4	0.7	0.5	-0.8	0.5
Supplements: Vitamin C	1.1	1.3	3.4	1.9	-0.1	0.7
Knee pain experienced in last month	0.7	1.1	1.3	-1.1	-1.0	-1.0
Hypertension (Self-reported)	0.4	1.1	1.8	1.4	0.2	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.8	0.0	-1.3	-1.1
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.2	-1.0	0.7
Illnesses of siblings: Diabetes	0.7	0.9	2.3	0.6	-1.5	0.3
Smoking status: Previous	1.8	2.7	4.6	2.1	-1.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	0.9	0.8	-0.4	-1.0
Whole body fat-free mass	0.3	1.6	4.0	0.4	0.8	-2.0
Leg fat-free mass (right)	0.3	1.4	4.0	0.5	0.1	-2.0
Arm fat percentage (left)	0.1	0.5	1.4	0.3	-1.2	-0.0
Average weekly red wine intake	0.6	0.9	1.7	0.4	-0.9	1.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.3	-1.0	1.1	0.3
Mood swings	0.0	0.1	0.1	-0.0	0.3	-0.2
Loneliness, isolation	0.2	0.3	0.8	0.1	-0.9	0.2
Long-standing illness, disability or infirmity	0.5	0.8	1.6	-0.5	-1.3	0.8
Ever had bowel cancer screening	0.4	0.5	0.7	0.5	-0.7	-0.8
Diabetes diagnosed by doctor	0.7	1.2	2.1	1.5	-0.9	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.5	0.6	0.6	-1.2
Friendships satisfaction	0.7	0.9	2.2	-1.5	-0.3	-0.6
Qualifications: nursing, teaching	0.3	0.5	1.3	0.3	-0.4	1.2
Commuting to job workplace: Walk	0.6	0.6	0.9	0.3	0.9	-0.9
Eye problems/disorders: Cataract	1.0	1.1	2.9	-0.3	-1.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.2	-0.7	2.1	-1.2
Medication for cholesterol	1.5	2.3	4.9	-2.2	1.5	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.1	-0.0	-0.6
Back pain experienced in last month	1.5	2.2	5.4	-2.3	-0.1	-1.0
Mineral and other dietary supplements	0.6	0.8	2.3	-0.3	-0.2	1.5
Breast cancer (self-reported)	0.1	0.1	0.4	-0.2	-0.6	0.1
Asthma (self-reported)	1.6	3.3	4.9	1.9	-1.2	-2.2
Osteoporosis (self-reported)	0.8	1.0	2.1	1.4	0.2	-0.9
Osteoarthritis (self-reported)	0.6	0.8	1.4	-0.1	-1.2	1.0
Medication: Aspirin	0.2	0.3	0.7	-0.4	-0.8	0.2
Medication: Gliclazide	0.5	0.6	1.2	1.1	-0.6	-0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	-0.4	1.3	-0.1
Smoking status: Current	0.3	0.4	0.7	-0.7	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.7	-1.5	0.2	-1.6
Whole body water mass	0.3	1.5	3.9	0.5	0.6	-2.0
Leg predicted mass (right)	0.2	1.3	3.7	0.4	0.1	-1.9
Arm fat mass (left)	0.1	0.3	0.5	0.4	-0.6	-0.7
Number of self-reported non-cancer illnesses	0.5	0.9	2.3	0.6	-1.5	-0.2
Average weekly champagne plus white wine intake	1.5	2.0	4.3	1.3	2.1	-0.3
Miserableness	0.4	0.7	1.3	-0.7	-1.1	0.7
Guilty feelings	1.0	1.4	2.8	0.8	-0.9	1.7
Wears glasses or contact lenses	0.9	1.1	2.0	1.4	0.5	-1.0
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.8	-0.2	-0.2
Hearing aid user	0.3	0.4	0.5	-0.1	0.7	-0.7
Mother’s age at death	0.3	0.4	0.7	-0.7	0.3	0.8
Financial situation satisfaction	0.5	0.7	1.8	-0.4	0.2	-1.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.0	0.5	-0.0
Commuting to job workplace: Public transport	0.9	1.1	2.4	-0.5	-0.7	-1.5
Eye problems/disorders: Glaucoma	2.0	2.3	3.8	-0.3	1.8	-1.9
Medication: Blood pressure	1.1	2.2	4.3	2.1	0.5	-1.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.5	-1.2	-1.2	0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.1	0.8	-0.4	-1.8
High cholesterol (Self-reported)	0.1	0.1	0.2	0.1	-0.4	0.4
Medication: Bendroflumethiazide	0.7	1.0	2.7	-0.4	1.7	-0.5
Medication: Paracetamol	0.6	0.9	1.9	-1.4	0.3	-0.9
Medication: Lisinopril	1.2	1.5	2.1	-1.0	1.3	-1.4
Medication: Atorvastatin	0.1	0.1	0.3	0.0	0.4	0.5
Illnesses of father: High blood pressure	1.6	1.9	4.3	1.0	0.7	-2.1
Alcohol drinker status: Never	0.3	0.4	0.9	-1.0	-0.4	0.0
Ever smoked	1.3	2.2	5.6	2.4	-1.0	-0.2
Basal metabolic rate	0.3	1.5	4.1	0.4	0.5	-2.0
Leg fat percentage (left)	0.2	0.6	1.4	-0.0	-1.2	0.7
Arm fat-free mass (left)	0.3	1.4	3.6	0.4	0.7	-1.9
Number of operations (self-reported)	1.4	2.1	3.0	1.7	-1.2	-1.4
Average weekly beer plus cider intake	0.4	0.5	1.1	0.1	-0.7	-1.1
Irritability	0.2	0.4	1.1	-0.4	-1.0	-0.1
Risk taking	0.3	0.5	1.0	0.5	-0.4	-1.0
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.7	1.7	0.0	-1.4
Fractured/broken bones in last 5 years	0.5	0.6	0.9	0.4	-0.9	-1.0
Age started oral contraceptive pill	0.3	0.4	1.1	-1.1	-0.1	0.2
Diastolic blood pressure, automated reading	0.9	2.7	6.6	2.6	0.5	1.1
Ever depressed for a whole week	0.4	0.5	0.7	0.8	0.3	-0.8
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	-0.3	0.3
Commuting to job workplace: Cycle	0.8	0.9	2.7	-1.6	-0.1	0.3
Myopia	0.6	0.8	1.4	1.2	-0.8	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	-0.9	-0.2	0.9
Cholesterol lowering medication	1.0	1.5	4.0	0.6	-2.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	0.6	-0.1	-0.6
Pain experienced in last month	0.2	0.4	0.9	0.5	1.0	-0.2
Supplements: Calcium	0.3	0.3	0.9	0.9	-0.0	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	-0.3	-0.9	-0.4
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.2	-0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.5	1.5	-1.6	-0.5
Heart disease (siblings)	0.8	1.0	2.4	0.7	-1.6	-0.2
Alcohol drinker status: Previous	1.2	1.4	3.9	2.0	-0.4	0.1
Pack years of smoking	0.2	0.3	0.5	-0.4	0.7	-0.6
Impedance of whole body	0.1	0.8	1.6	-0.3	-0.7	1.3
Leg fat mass (left)	0.1	0.3	0.7	0.3	-0.8	-0.2
Arm predicted mass (left)	0.2	1.1	2.9	0.3	0.6	-1.7