Hub : Genes

PIK3R5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0841 0.0327 4.4e-03 0.002 NA -0.003 NA -0.003 1.9e-01 NA 8.6e-01 NA 8.9e-01
2 GTEx Testis 0.4220 0.0740 1.8e-07 0.399 NA 0.381 NA 0.402 6.1e-19 NA 5.6e-18 NA 3.9e-19
3 GTEx Vagina 0.4830 0.1250 2.4e-03 0.012 NA 0.002 NA 0.008 1.7e-01 NA 2.8e-01 NA 2.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.3 3.0 -1.7 -0.3 0.9
Bipolar Disorder or Schizophrenia 1.2 2.9 8.5 -2.9 -0.5 -0.1
Depressed Affect (Nagel 2018) 0.8 1.7 3.8 -0.9 -1.9 0.6
Depression (Nagel 2018) 1.7 2.6 4.1 -0.5 -1.9 2.0
Intelligence (Savage-Jansen 2018) 0.8 2.6 4.0 2.0 0.1 1.9
Neuroticism (Nagel 2018) 0.8 1.8 3.9 -0.5 -1.1 2.0
Schizophrenia (2018) 1.0 2.0 5.1 -2.3 -0.5 -0.8
Schizophrenia vs Biploar Disorder 0.5 0.6 1.2 0.5 -1.1 -0.6
Worry (Nagel 2018) 0.4 0.8 2.3 -0.2 0.1 1.5
Alzheimer’s Disease (in mother) 0.9 1.0 2.6 0.5 1.6 -0.6
Alzheimer’s Disease (in father) 1.5 1.7 3.3 -1.2 -1.8 0.4
Alzheimer’s Disease (including proxy) 0.4 0.6 1.6 -1.2 0.3 0.3
Crohns Disease (2017) 0.8 1.7 2.6 1.3 0.8 1.6
Irritable Bowel Disease (IBD) 0.2 0.4 1.0 1.0 0.3 -0.0
Ulcerative Colitis (UC) 0.5 0.9 1.9 0.6 -0.7 -1.4
Major Depression (MDD) 0.4 0.5 1.5 1.2 -0.1 0.3
Reaction Time 0.1 0.1 0.2 0.0 -0.4 0.5
Verbal and Numeric Reasoning (VNR) 1.2 2.8 6.3 1.4 -0.1 2.5
Breast Cancer 0.1 0.2 0.3 0.0 0.6 -0.6
Ovarian Cancer 0.9 1.2 2.5 1.6 1.0 0.1
Prostate Cancer 0.7 1.0 1.5 1.2 -1.1 -0.5
Age at First Birth 0.4 0.6 1.0 -0.9 -1.0 0.1
Bipolar Disorder (2011) 1.7 1.6 3.5 -1.1 -0.5 1.9
Body Mass Index (BMI) (2010) 0.4 0.5 0.8 0.3 -0.9 -0.7
Coronary Artery Disease (CAD) 0.9 1.1 2.4 -1.6 -0.0 0.9
Crohns Disease (2012) 2.7 4.3 11.8 1.0 -0.3 3.4
Mean Putamen Volume 0.3 0.4 0.5 0.6 0.7 -0.5
Fasting Glucose 1.5 1.8 4.4 -0.2 -2.1 0.9
HbA1C 1.8 2.0 4.2 -2.0 1.2 -0.6
HDL Cholesterol 0.1 0.2 0.6 0.7 0.0 0.1
LDL Cholesterol 0.5 0.9 1.7 -0.1 -1.3 -0.9
Lupus 0.1 0.2 0.3 -0.5 0.1 -0.5
Neuroticism (2016) 1.1 1.7 2.0 -1.4 -1.1 1.3
Primary Biliary Cirrhosis 1.2 1.7 4.1 -0.9 0.4 2.0
Rheumatoid Arthritis 0.7 0.9 1.8 -0.7 -1.3 0.7
Schizophrenia (2014) 1.0 2.1 5.0 -2.2 -0.7 -0.9
Triglycerides 0.2 0.3 0.4 -0.6 -0.3 -0.7
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 0.3 0.1 -0.5
Ulcerative Colitis 0.0 0.1 0.2 -0.2 -0.1 -0.4
Blood Eosinophil Count 2.2 17.3 34.8 -0.7 5.9 -4.1
Blood Platelet Count 0.2 2.3 5.2 1.2 -2.3 0.4
Blood Red Count 0.1 1.3 2.8 1.7 0.9 -0.7
Blood White Count 0.3 2.0 3.9 1.3 0.6 -2.0
Heel T-Score 0.1 1.1 2.7 1.6 -0.5 0.6
BMI 0.2 1.4 3.3 0.5 0.7 -1.8
Height 0.0 0.5 1.3 0.3 1.2 -0.4
Waist Hip Ratio (WHR) 0.2 1.0 1.4 -0.7 -1.2 -1.0
Systolic Blood Pressure 0.1 0.7 1.8 1.3 0.3 0.5
Smoking Status 0.5 1.1 3.1 1.8 -0.6 0.1
Allergy or Eczema 0.4 1.1 2.0 -0.7 -1.0 1.4
Cardiovascular Disease 0.7 2.2 2.8 1.3 1.7 -1.5
Hypothyroidism (self reported) 3.0 6.8 10.3 -1.2 -2.9 3.2
Respiratory disease 0.3 0.7 1.0 1.0 -1.0 -0.2
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.1 1.1 0.6 -0.0
Lung FEV1/FVC ratio 0.1 0.3 0.5 -0.2 0.6 -0.7
Lung FVC 0.5 2.4 4.7 -1.2 -1.1 2.2
Neuroticism 0.7 1.6 2.5 -1.1 -1.0 1.6
Chronotype (morning person) 0.6 1.3 1.9 -0.9 -1.4 1.1
Hair Pigment 0.0 1.1 1.8 1.0 -1.4 0.7
Tanning 0.2 2.7 7.4 -0.2 -0.8 -2.7
Hand grip strength (left) 0.8 2.2 3.5 -1.9 1.7 -0.6
Number of treatments/medications taken 0.3 0.5 1.1 0.2 -1.0 -0.5
Average weekly spirits intake 0.4 0.5 1.1 0.2 1.1 -0.5
Sensitivity / hurt feelings 1.6 2.7 5.4 -1.6 0.0 2.3
Frequency of depressed mood in last 2 weeks 0.9 1.2 3.0 -0.0 -1.7 0.8
Hearing difficulty/problems: Yes 0.6 0.9 2.0 -1.4 -0.5 0.7
Relative age of first facial hair 0.6 1.3 3.6 -1.9 -0.2 0.3
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.2 -1.3 -1.5 0.1
Ever used hormone-replacement therapy (HRT) 1.3 1.7 3.8 2.0 -1.0 0.4
Ever had hysterectomy (womb removed) 0.8 0.9 2.5 0.2 -0.5 -1.6
Systolic blood pressure, automated reading 0.5 1.5 2.5 1.4 0.3 1.6
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 1.3 -0.1 0.6
Angina 0.2 0.3 0.5 0.7 -0.3 -0.6
Medication for hormone replacement therapy 1.2 1.3 2.2 1.5 -1.1 0.8
Vitamin and mineral supplements 0.7 1.0 2.6 -1.6 0.1 0.6
Supplements: Zinc 1.0 1.1 1.4 1.0 1.2 0.9
Medication: Co-codamol 0.6 0.7 1.3 -0.8 -1.1 -0.5
Medication: Metformin 0.9 1.3 2.3 1.5 -0.1 -1.2
Diabetes (father) 0.5 0.6 1.2 0.5 0.5 1.1
Diabetes (mother) 2.2 2.8 6.2 2.5 -1.5 -0.4
Severe depression (siblings) 2.3 2.5 2.9 1.4 -1.6 1.7
Pack years adult smoking proportion 0.4 0.6 1.0 -0.1 1.0 -0.8
Impedance of leg (right) 0.1 0.5 1.4 -0.4 -0.0 1.2
Leg fat-free mass (left) 0.3 1.6 4.2 0.8 0.1 -2.0
Trunk fat percentage 0.2 1.0 2.3 0.7 -1.5 -0.4
Hand grip strength (right) 0.3 0.9 1.1 -0.9 0.9 -1.1
Townsend deprivation index at recruitment 0.3 0.4 1.0 -0.2 -0.1 -1.0
Current tobacco smoking 0.3 0.5 0.7 -0.4 0.8 -0.7
Average weekly fortified wine intake 0.3 0.3 0.6 -0.8 0.4 -0.5
Maternal smoking around birth 0.4 0.6 1.3 1.1 0.0 -0.6
Fed-up feelings 0.5 0.8 1.4 -1.2 -1.0 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.8 -0.7 -1.3 0.3
Relative age voice broke 0.7 1.1 2.2 -1.5 0.6 -0.9
Taking other prescription medications 0.5 0.7 1.4 -1.2 -0.8 -0.4
Age when periods started (menarche) 0.5 1.2 2.3 -0.2 1.1 -1.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.9 -0.2 -0.6 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.3 1.0 -0.3 1.1
Tinnitus: Yes, but not now, but have in the past 2.1 2.2 5.1 -0.9 2.3 -0.9
Qualifications: CSEs or equivalent 0.7 0.9 1.2 -1.1 0.7 -1.0
Serious illness, injury or assault to yourself 0.4 0.5 1.4 -1.2 -0.0 -0.4
High blood pressure 0.6 1.7 3.2 1.8 0.3 -1.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 -0.7 -0.2 0.1
Multivitamins +/- minerals 0.3 0.4 0.5 0.7 0.3 -0.7
Stomach or abdominal pain in last month 0.8 1.0 2.9 -0.5 -0.1 -1.7
Supplements: Glucosamine 1.0 1.3 3.6 -0.2 -1.9 0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.6 -0.4 -0.8 0.1
Medication: Atenolol 0.7 0.9 2.4 -0.6 1.6 -0.0
Medication: Levothyroxine sodium 2.1 3.6 4.8 -1.4 -1.9 2.2
Sitting height 0.1 0.9 1.1 0.9 1.1 -0.8
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 -0.1 -0.7 -0.4
High blood pressure (mother) 0.5 0.7 1.9 0.3 -1.4 -0.4
Body mass index (BMI) 0.1 0.5 0.7 0.2 -0.9 -0.9
Impedance of leg (left) 0.1 0.7 1.8 -0.6 -0.2 1.3
Leg predicted mass (left) 0.3 1.7 4.2 0.9 0.1 -2.1
Trunk fat mass 0.2 0.7 1.0 0.6 -1.0 -0.9
Waist circumference 0.5 1.9 4.2 0.5 -1.1 -2.0
Number of incorrect matches in round 0.5 0.8 2.0 0.4 1.4 -0.5
Past tobacco smoking 1.7 3.1 6.1 -2.5 1.7 -0.7
Alcohol usually taken with meals 0.4 0.7 1.1 1.1 -0.3 0.9
Nervous feelings 0.7 1.4 3.3 0.7 0.6 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.9 -0.2 -0.9 -0.6
Hearing difficulty/problems with background noise 2.2 3.6 10.4 -3.2 0.6 -0.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.5 -0.6 -0.4 -1.2
Had menopause 0.6 0.8 1.9 1.4 -0.6 0.2
Had other major operations 2.5 3.1 6.3 1.6 0.7 -2.5
Forced vital capacity (FVC) 0.1 0.3 0.4 -0.5 0.5 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.1 0.9 0.2 1.0
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.1 0.0 -0.0 -0.2
Qualifications: None of the above 0.5 1.0 2.9 0.2 -1.7 -0.2
Financial difficulties in last 2 years 1.1 1.5 1.7 -1.3 -1.3 1.1
Mouth/teeth dental problems 0.6 1.0 1.7 -1.3 -0.9 0.5
Heart attack 0.0 0.0 0.1 -0.2 -0.2 -0.2
Allergy 0.6 1.4 4.0 0.3 2.0 0.1
Pain all over the body in last month 0.6 0.6 1.7 0.3 -0.3 1.3
Diabetes (self-reported) 0.7 1.1 3.1 1.8 -0.5 0.1
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.8 0.2 1.3 0.1
Medication: Ramipril 0.4 0.5 1.3 0.5 1.1 0.1
Medication: Simvastatin 0.5 0.8 2.2 0.5 -1.5 0.1
Fluid intelligence score 2.0 4.2 12.0 0.8 0.0 3.5
Illnesses of siblings 0.9 1.3 2.4 -1.1 1.5 0.5
Neuroticism score 0.8 1.6 1.9 -1.4 -1.1 1.3
Weight 0.2 0.9 2.6 0.3 -0.1 -1.6
Impedance of arm (right) 0.1 0.3 0.5 -0.1 -0.7 0.6
Arm fat percentage (right) 0.1 0.5 1.4 0.1 -1.2 -0.2
Trunk fat-free mass 0.3 1.7 3.7 0.2 1.1 -1.9
Hip circumference 0.2 0.7 1.5 0.7 0.5 -1.2
Time employed in main current job 0.7 0.8 2.0 -1.4 0.1 0.7
Alcohol intake versus 10 years previously 0.6 0.9 1.4 -0.8 -0.8 -1.2
Father’s age at death 1.1 1.5 2.1 -0.9 -1.3 1.4
Worrier / anxious feelings 0.6 1.1 2.7 1.6 -0.5 0.5
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 5.3 -2.3 -1.3 0.8
Falls in the last year 0.9 1.3 2.1 -1.3 0.4 -1.4
Hair/balding pattern: Pattern 3 0.5 0.7 1.5 0.7 -0.4 -1.2
Number of live births 0.7 0.9 1.8 0.7 1.3 -0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.4 -0.6 0.4 -0.6
Pulse rate 0.2 0.3 0.7 -0.4 -0.4 -0.8
Happiness 0.7 0.9 1.6 -1.0 -1.3 0.0
Noisy workplace 2.2 2.7 8.0 -0.2 0.3 -2.8
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.1 0.1 0.5 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.0 1.4 0.0 -0.1
Mouth/teeth dental problems: Dentures 1.0 1.7 3.8 2.0 -1.1 0.3
Asthma 1.8 3.6 4.4 2.1 -1.5 -2.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.3 0.4 1.1 -0.8
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.1 0.0 -0.5
Depression (self-reported) 2.1 2.5 5.5 1.0 -0.9 2.4
Medication: Lansoprazole 1.2 1.4 2.2 -0.9 -1.1 1.5
Prospective memory result 0.7 0.9 1.7 -0.8 0.3 -1.3
Lung cancer (father) 0.6 0.7 1.9 0.4 -0.1 -1.4
Illnesses of mother 0.5 0.7 1.2 1.1 0.9 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.7 -0.8 0.2 -0.2
Pulse wave Arterial Stiffness index 1.1 1.3 1.6 1.2 -0.9 1.2
Impedance of arm (left) 0.0 0.2 0.3 0.0 -0.5 0.5
Arm fat mass (right) 0.1 0.4 0.7 0.3 -0.9 -0.7
Trunk predicted mass 0.3 1.6 3.4 0.2 1.1 -1.8
Standing height 0.2 1.8 3.1 0.3 1.4 -1.8
Length of working week for main job 0.4 0.5 0.9 0.2 0.7 -0.9
Exposure to tobacco smoke at home 1.3 1.4 2.0 1.3 -1.4 0.8
Breastfed as a baby 1.1 1.4 2.2 -1.5 1.3 -0.4
Tense / ‘highly strung’ 0.3 0.6 0.9 0.5 0.7 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.0 0.9 -1.0 -0.4
Hair/balding pattern: Pattern 4 0.5 1.1 3.0 0.0 1.7 -0.6
Birth weight of first child 0.3 0.6 1.6 0.0 1.3 -0.4
Peak expiratory flow (PEF) 0.1 0.2 0.3 -0.1 -0.5 0.4
Pulse wave reflection index 0.3 0.3 0.9 0.1 0.2 1.0
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.0 0.1 -1.4 -0.3
Loud music exposure frequency 0.7 0.7 2.0 -0.3 -1.4 0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.9 -0.3 1.4 0.1
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 4.5 2.1 0.7 0.3
Blood clot in the leg (DVT) 1.3 1.7 3.5 1.1 -1.9 -0.6
Medication: Paracetamol 0.5 0.8 1.9 -1.4 0.6 -0.4
Headache pain in last month 0.4 0.6 1.8 -0.2 -1.3 -0.1
Medication for cholesterol, blood pressure or diabetes 0.0 0.0 0.1 0.3 -0.1 -0.1
Glaucoma (self-reported) 1.1 1.3 2.4 -0.2 1.2 -1.6
Gout (self-reported) 2.6 3.6 7.6 -0.2 1.7 -2.8
Hypothyroidism/myxoedema (self-reported) 3.0 5.8 9.4 -0.9 -3.1 2.7
Medication: Amlodipine 0.2 0.3 0.5 -0.7 -0.1 -0.7
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.6 0.0 -1.9 1.0
Birth weight 0.5 1.0 2.0 -0.3 0.9 -1.4
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.3 -0.3 -0.2 0.5
High blood pressure (siblings) 1.2 1.7 5.1 2.2 -0.2 -0.2
Forced vital capacity (FVC), Best measure 0.2 0.8 1.4 -1.2 0.9 -0.3
Body fat percentage 0.2 0.9 2.5 0.4 -1.6 0.1
Leg fat percentage (right) 0.2 0.7 1.7 0.1 -1.3 0.7
Arm fat-free mass (right) 0.3 1.5 3.3 0.9 0.5 -1.8
Exposure to tobacco smoke outside home 0.7 0.9 1.7 -0.2 -1.0 1.3
Comparative body size at age 10 0.5 1.4 4.3 2.1 -0.1 0.0
Number of full brothers 0.7 0.9 2.3 -1.5 -0.7 0.1
Worry too long after embarrassment 0.7 1.2 3.1 -0.7 0.3 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 1.3 0.7 -1.1 1.1
Wheeze or whistling in the chest in last year 0.5 0.9 2.7 -0.2 -1.6 -0.3
Number of children fathered 1.6 1.8 3.1 1.8 -0.8 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 5.2 2.3 0.6 0.3
Age at first live birth 0.1 0.1 0.4 0.1 0.0 0.6
Pulse wave peak to peak time 1.0 1.2 1.6 -1.3 1.0 -1.1
Health satisfaction 0.7 0.9 2.0 -1.4 0.3 -0.7
Shortness of breath walking on level ground 0.2 0.3 0.7 -0.3 0.0 -0.8
Qualifications: College or University degree 0.1 0.2 0.3 0.6 0.4 0.2
Eye problems/disorders: None of the above 0.5 0.6 1.4 0.1 1.2 0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 0.4 -0.4 0.7
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.2 -0.5 -0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 0.2 -0.4 0.5
Neck or shoulder pain in last month 0.6 0.9 2.2 -1.5 -0.1 0.5
Medication: Blood pressure 0.2 0.3 0.8 -0.3 0.0 -0.9
Angina (self-reported) 0.3 0.4 0.6 0.8 -0.6 -0.5
Migraine (self-reported) 0.0 0.1 0.1 -0.2 -0.3 0.3
Medication: Ibuprofen 1.4 1.6 4.3 0.1 0.8 -2.1
Medication: Allopurinol 2.4 3.1 7.1 -1.0 1.2 -2.7
Medication: Omeprazole 0.5 0.5 1.5 1.2 -0.2 -0.2
Medication: Seretide 50 evohaler 4.4 5.0 7.2 2.7 -2.0 2.0
Mean time to correctly identify matches 0.1 0.2 0.4 0.1 -0.6 -0.4
Heart disease (mother) 0.5 0.7 1.1 -1.1 -0.9 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.1 -0.3 -0.1 -0.3
Whole body fat mass 0.2 0.6 1.0 0.6 -1.0 -0.7
Leg fat mass (right) 0.1 0.4 1.0 0.5 -1.0 -0.3
Arm predicted mass (right) 0.2 1.3 2.9 0.6 0.7 -1.7
Pulse rate, automated reading 0.2 0.6 1.7 -0.5 -0.1 -1.3
Alcohol intake frequency. 0.7 1.6 4.5 -0.1 -2.1 -0.6
Comparative height size at age 10 0.1 0.6 1.3 -0.5 1.1 -0.5
Number of full sisters 0.4 0.5 0.9 0.3 0.8 -0.9
Suffer from ‘nerves’ 0.2 0.3 0.7 0.2 0.8 0.4
Overall health rating 0.4 0.9 1.4 -1.0 -1.2 0.4
Chest pain or discomfort 0.8 1.1 1.8 1.4 0.7 -1.1
Had major operations 0.7 0.9 1.4 1.1 -1.2 0.2
Age at last live birth 0.1 0.2 0.3 0.6 -0.1 0.5
Family relationship satisfaction 0.7 0.9 1.2 -0.8 -1.1 -0.9
Leg pain on walking 0.4 0.5 0.9 0.1 -0.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.2 -1.8 -0.0 -0.6
Commuting to job workplace: Car/motor vehicle 2.6 3.0 6.7 1.4 0.5 2.6
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.2 -0.2 1.3 -1.8
Medication: Aspirin 0.3 0.4 0.7 0.5 -0.8 0.5
Supplements: Vitamin C 1.1 1.3 3.4 1.9 -0.1 0.7
Knee pain experienced in last month 0.7 1.1 1.3 -1.1 -1.0 -1.0
Hypertension (Self-reported) 0.4 1.1 1.8 1.4 0.2 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.8 0.0 -1.3 -1.1
Illnesses of father: Heart disease 0.4 0.5 0.9 -0.2 -1.0 0.7
Illnesses of siblings: Diabetes 0.7 0.9 2.3 0.6 -1.5 0.3
Smoking status: Previous 1.8 2.7 4.6 2.1 -1.8 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 0.9 0.8 -0.4 -1.0
Whole body fat-free mass 0.3 1.6 4.0 0.4 0.8 -2.0
Leg fat-free mass (right) 0.3 1.4 4.0 0.5 0.1 -2.0
Arm fat percentage (left) 0.1 0.5 1.4 0.3 -1.2 -0.0
Average weekly red wine intake 0.6 0.9 1.7 0.4 -0.9 1.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.3 -1.0 1.1 0.3
Mood swings 0.0 0.1 0.1 -0.0 0.3 -0.2
Loneliness, isolation 0.2 0.3 0.8 0.1 -0.9 0.2
Long-standing illness, disability or infirmity 0.5 0.8 1.6 -0.5 -1.3 0.8
Ever had bowel cancer screening 0.4 0.5 0.7 0.5 -0.7 -0.8
Diabetes diagnosed by doctor 0.7 1.2 2.1 1.5 -0.9 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.5 0.6 0.6 -1.2
Friendships satisfaction 0.7 0.9 2.2 -1.5 -0.3 -0.6
Qualifications: nursing, teaching 0.3 0.5 1.3 0.3 -0.4 1.2
Commuting to job workplace: Walk 0.6 0.6 0.9 0.3 0.9 -0.9
Eye problems/disorders: Cataract 1.0 1.1 2.9 -0.3 -1.7 -0.6
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 4.2 -0.7 2.1 -1.2
Medication for cholesterol 1.5 2.3 4.9 -2.2 1.5 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 -0.1 -0.0 -0.6
Back pain experienced in last month 1.5 2.2 5.4 -2.3 -0.1 -1.0
Mineral and other dietary supplements 0.6 0.8 2.3 -0.3 -0.2 1.5
Breast cancer (self-reported) 0.1 0.1 0.4 -0.2 -0.6 0.1
Asthma (self-reported) 1.6 3.3 4.9 1.9 -1.2 -2.2
Osteoporosis (self-reported) 0.8 1.0 2.1 1.4 0.2 -0.9
Osteoarthritis (self-reported) 0.6 0.8 1.4 -0.1 -1.2 1.0
Medication: Aspirin 0.2 0.3 0.7 -0.4 -0.8 0.2
Medication: Gliclazide 0.5 0.6 1.2 1.1 -0.6 -0.3
Illnesses of father: None of the above (group 1) 0.5 0.6 1.8 -0.4 1.3 -0.1
Smoking status: Current 0.3 0.4 0.7 -0.7 0.8 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 2.7 -1.5 0.2 -1.6
Whole body water mass 0.3 1.5 3.9 0.5 0.6 -2.0
Leg predicted mass (right) 0.2 1.3 3.7 0.4 0.1 -1.9
Arm fat mass (left) 0.1 0.3 0.5 0.4 -0.6 -0.7
Number of self-reported non-cancer illnesses 0.5 0.9 2.3 0.6 -1.5 -0.2
Average weekly champagne plus white wine intake 1.5 2.0 4.3 1.3 2.1 -0.3
Miserableness 0.4 0.7 1.3 -0.7 -1.1 0.7
Guilty feelings 1.0 1.4 2.8 0.8 -0.9 1.7
Wears glasses or contact lenses 0.9 1.1 2.0 1.4 0.5 -1.0
Ever taken oral contraceptive pill 0.2 0.2 0.6 -0.8 -0.2 -0.2
Hearing aid user 0.3 0.4 0.5 -0.1 0.7 -0.7
Mother’s age at death 0.3 0.4 0.7 -0.7 0.3 0.8
Financial situation satisfaction 0.5 0.7 1.8 -0.4 0.2 -1.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 -0.0 0.5 -0.0
Commuting to job workplace: Public transport 0.9 1.1 2.4 -0.5 -0.7 -1.5
Eye problems/disorders: Glaucoma 2.0 2.3 3.8 -0.3 1.8 -1.9
Medication: Blood pressure 1.1 2.2 4.3 2.1 0.5 -1.4
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.5 -1.2 -1.2 0.3
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.1 0.8 -0.4 -1.8
High cholesterol (Self-reported) 0.1 0.1 0.2 0.1 -0.4 0.4
Medication: Bendroflumethiazide 0.7 1.0 2.7 -0.4 1.7 -0.5
Medication: Paracetamol 0.6 0.9 1.9 -1.4 0.3 -0.9
Medication: Lisinopril 1.2 1.5 2.1 -1.0 1.3 -1.4
Medication: Atorvastatin 0.1 0.1 0.3 0.0 0.4 0.5
Illnesses of father: High blood pressure 1.6 1.9 4.3 1.0 0.7 -2.1
Alcohol drinker status: Never 0.3 0.4 0.9 -1.0 -0.4 0.0
Ever smoked 1.3 2.2 5.6 2.4 -1.0 -0.2
Basal metabolic rate 0.3 1.5 4.1 0.4 0.5 -2.0
Leg fat percentage (left) 0.2 0.6 1.4 -0.0 -1.2 0.7
Arm fat-free mass (left) 0.3 1.4 3.6 0.4 0.7 -1.9
Number of operations (self-reported) 1.4 2.1 3.0 1.7 -1.2 -1.4
Average weekly beer plus cider intake 0.4 0.5 1.1 0.1 -0.7 -1.1
Irritability 0.2 0.4 1.1 -0.4 -1.0 -0.1
Risk taking 0.3 0.5 1.0 0.5 -0.4 -1.0
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.7 1.7 0.0 -1.4
Fractured/broken bones in last 5 years 0.5 0.6 0.9 0.4 -0.9 -1.0
Age started oral contraceptive pill 0.3 0.4 1.1 -1.1 -0.1 0.2
Diastolic blood pressure, automated reading 0.9 2.7 6.6 2.6 0.5 1.1
Ever depressed for a whole week 0.4 0.5 0.7 0.8 0.3 -0.8
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.4 -0.3 0.3
Commuting to job workplace: Cycle 0.8 0.9 2.7 -1.6 -0.1 0.3
Myopia 0.6 0.8 1.4 1.2 -0.8 0.7
Vascular/heart problems diagnosed by doctor 0.2 0.6 0.9 -0.9 -0.2 0.9
Cholesterol lowering medication 1.0 1.5 4.0 0.6 -2.0 0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.4 0.6 -0.1 -0.6
Pain experienced in last month 0.2 0.4 0.9 0.5 1.0 -0.2
Supplements: Calcium 0.3 0.3 0.9 0.9 -0.0 -0.2
Basal cell carcinoma (self-reported) 0.3 0.3 0.7 -0.3 -0.9 -0.4
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 -0.2 -0.3 0.1
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 2.5 1.5 -1.6 -0.5
Heart disease (siblings) 0.8 1.0 2.4 0.7 -1.6 -0.2
Alcohol drinker status: Previous 1.2 1.4 3.9 2.0 -0.4 0.1
Pack years of smoking 0.2 0.3 0.5 -0.4 0.7 -0.6
Impedance of whole body 0.1 0.8 1.6 -0.3 -0.7 1.3
Leg fat mass (left) 0.1 0.3 0.7 0.3 -0.8 -0.2
Arm predicted mass (left) 0.2 1.1 2.9 0.3 0.6 -1.7