Hub : Genes

PRPF6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue 0.218 0.0680 6.1e-04 0.007 NA 0.005 NA 0.024 1.3e-01 NA 1.6e-01 NA 2.2e-02
2 GTEx Breast Mammary Tissue (Male) 0.226 0.1087 4.3e-02 0.020 NA 0.133 NA 0.079 1.1e-01 NA 5.5e-04 NA 7.0e-03
3 GTEx Breast Mammary Tissue (Female) 0.103 0.0873 1.7e-01 -0.010 NA -0.009 NA -0.010 1.0e+00 NA 7.8e-01 NA 8.9e-01
4 GTEx Cells EBV-transformed lymphocytes 0.267 0.0890 5.0e-03 0.189 NA 0.042 NA 0.133 9.3e-07 NA 1.6e-02 NA 4.1e-05
5 GTEx Esophagus Mucosa 0.156 0.0540 1.6e-03 -0.004 NA -0.004 NA -0.004 7.8e-01 NA 9.6e-01 NA 9.8e-01
6 GTEx Muscle Skeletal 0.146 0.0421 3.3e-05 0.002 NA 0.002 NA 0.009 2.0e-01 NA 1.7e-01 NA 3.6e-02
7 ROSMAP Brain Pre-frontal Cortex 0.154 0.0359 3.0e-07 0.054 0.072 0.117 0.1 0.113 1.8e-07 1.4e-09 7.5e-15 9.4e-13 2.6e-14
8 TCGA Lung Squamous Cell Carcinoma 0.056 0.0340 4.2e-03 0.013 0.019 0.018 NA 0.011 1.1e-02 2.8e-03 3.7e-03 NA 1.6e-02
9 TCGA Prostate Adenocarcinoma 0.106 0.0425 8.1e-04 0.009 0.038 0.036 NA 0.021 3.8e-02 7.7e-05 9.9e-05 NA 2.7e-03
10 TCGA Thyroid Carcinoma 0.050 0.0260 4.1e-03 0.001 0.022 0.003 NA 0.008 2.8e-01 2.6e-03 1.4e-01 NA 4.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 2.0 3.2 9.2 1.6 2.8 1.1 -3.0 0.6 2.3 0.8 0.6 1.6 1.1
Bipolar Disorder or Schizophrenia 0.7 1.6 6.5 1.8 2.5 1.0 -1.4 -0.5 0.5 -1.5 -0.5 -0.7 -0.6
Depressed Affect (Nagel 2018) 0.5 1.0 2.9 -1.0 -1.7 -1.1 -0.0 -1.2 0.9 0.2 -1.1 -0.3 -1.3
Depression (Nagel 2018) 0.7 1.1 2.8 -1.7 -0.9 -1.7 1.1 -0.9 -0.4 -1.4 -0.4 0.1 0.1
Intelligence (Savage-Jansen 2018) 0.9 2.8 7.0 2.2 2.5 0.1 -2.6 1.0 2.0 1.9 -0.6 -0.6 -0.4
Neuroticism (Nagel 2018) 0.4 0.9 5.1 -0.8 -0.9 -2.3 -0.4 -0.7 0.7 0.3 -1.0 -0.2 -0.8
Schizophrenia (2018) 1.1 2.4 7.0 1.0 1.0 0.4 0.7 -1.0 -1.2 -2.6 -1.6 -2.4 -1.9
Schizophrenia vs Biploar Disorder 0.4 0.6 2.4 0.4 -0.6 -0.3 1.6 -0.4 -0.8 -1.4 0.0 0.0 0.0
Worry (Nagel 2018) 0.3 0.6 2.7 -0.0 -0.8 -1.6 0.4 0.2 -0.3 -0.6 -0.7 -1.1 -0.6
Alzheimer’s Disease (in mother) 0.3 0.4 1.6 -0.0 -0.9 1.2 0.2 -0.8 0.2 -0.3 0.4 0.1 0.7
Alzheimer’s Disease (in father) 0.7 0.7 2.0 -1.1 -1.4 -0.4 1.4 0.4 -0.7 0.0 0.6 0.8 0.8
Alzheimer’s Disease (including proxy) 0.2 0.4 0.9 -0.4 -0.8 0.8 0.5 -0.3 -0.2 -0.1 0.8 0.6 1.0
Crohns Disease (2017) 1.1 2.5 8.2 -1.5 -1.5 1.0 -1.3 -2.5 2.9 1.5 -0.6 -0.5 -0.6
Irritable Bowel Disease (IBD) 0.8 1.9 7.0 -2.0 -1.3 1.5 -0.9 -1.1 2.6 0.8 0.7 -0.6 0.2
Ulcerative Colitis (UC) 0.7 1.4 3.8 -1.4 -0.9 1.6 -0.2 1.0 1.5 0.7 1.9 -0.3 1.0
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.2 0.4 1.7 0.1 0.1 0.7 -0.0 0.3 -0.5 -1.1 -0.6 1.3 -0.0
Verbal and Numeric Reasoning (VNR) 1.3 3.2 9.0 2.6 1.2 0.2 -2.7 -0.5 3.0 1.5 -1.9 -0.3 -1.0
Breast Cancer 1.4 3.4 10.2 -1.1 -3.2 -2.6 0.7 0.1 0.8 0.7 -2.6 -1.7 -2.2
Ovarian Cancer 1.3 1.8 6.2 -2.0 -1.2 0.8 -0.2 -0.4 0.6 0.7 -0.3 -2.1 -2.5
Prostate Cancer 0.9 1.2 3.6 0.7 -0.3 -1.9 -0.7 -1.1 0.9 1.8 0.1 1.4 0.6
Age at First Birth 0.5 0.7 2.8 1.7 1.1 0.3 0.3 0.3 -0.3 -1.2 0.2 1.0 0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 -1.3 -0.9 1.0 1.3 0.4 -0.8 -0.9 0.9 -0.4 -0.1
Coronary Artery Disease (CAD) 1.0 1.2 5.6 -1.8 -2.4 -1.3 0.7 -0.7 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.4 2.3 9.3 -1.1 -0.4 0.3 -1.8 -2.5 3.0 1.2 0.4 0.5 0.7
Mean Putamen Volume 0.8 1.0 3.2 0.7 1.8 1.1 0.6 -0.0 -1.2 -1.5 -0.5 0.4 0.5
Fasting Glucose 0.9 1.0 3.5 0.6 1.4 -1.9 -0.9 1.2 -0.4 0.9 -1.0 0.1 -0.5
HbA1C 1.3 1.4 4.2 0.3 -1.2 0.2 -0.9 -0.5 0.8 1.0 -2.1 -1.4 -1.9
HDL Cholesterol 0.8 1.4 3.7 0.6 1.8 -0.7 0.3 1.9 -1.2 0.7 1.7 0.1 1.0
LDL Cholesterol 0.6 0.9 2.3 1.5 0.3 -0.8 0.6 0.4 -0.9 -1.5 -1.5 0.0 -0.9
Lupus 0.5 0.8 3.5 -0.4 1.9 -1.0 -0.5 1.2 -0.2 0.2 -0.3 1.0 0.3
Neuroticism (2016) 2.1 3.0 7.9 -1.3 0.2 -2.8 -1.1 0.8 0.4 0.8 -2.4 -2.2 -2.7
Primary Biliary Cirrhosis 0.4 0.6 2.4 -0.5 -0.7 0.3 0.2 0.1 0.1 0.3 0.4 1.5 1.5
Rheumatoid Arthritis 2.6 3.6 14.6 -0.3 -0.6 1.9 1.3 1.5 -1.8 0.2 3.8 1.2 2.9
Schizophrenia (2014) 0.5 1.2 2.8 1.0 1.6 0.4 -0.4 -0.1 -0.1 -1.7 -0.9 -1.7 -1.2
Triglycerides 0.7 1.2 2.9 1.4 -1.3 1.7 0.3 -1.4 0.4 -0.3 -1.2 -0.3 -1.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 4.0 -0.7 -1.0 0.5 -0.1 -2.0 0.0 0.1 0.0 0.0 0.0
Ulcerative Colitis 0.5 0.7 3.1 -1.8 -0.8 0.2 -0.2 -0.7 1.1 -0.8 -0.0 -0.9 -0.2
Blood Eosinophil Count 0.5 3.9 15.0 1.4 1.2 1.9 -0.7 -3.9 1.9 -1.9 -0.1 1.9 2.4
Blood Platelet Count 0.3 3.2 21.8 -0.0 -2.3 -1.6 -0.1 -4.7 1.2 -0.6 -0.7 0.0 0.6
Blood Red Count 0.2 2.2 5.6 1.6 2.0 2.4 -0.4 -0.0 -1.2 -1.1 -1.6 -0.5 -2.1
Blood White Count 0.8 6.1 20.2 2.1 -1.2 1.2 -1.4 -2.3 1.4 1.8 1.6 4.5 4.3
Heel T-Score 0.7 5.6 20.3 1.5 1.5 -0.2 -3.6 3.3 1.4 4.5 -1.6 1.6 -0.0
BMI 0.3 1.9 8.9 -3.0 -2.0 0.5 1.1 -1.3 -0.9 0.5 1.3 0.7 -0.3
Height 0.3 5.2 21.4 1.2 1.8 -4.6 -1.9 -1.8 3.3 -0.7 -2.0 1.6 0.6
Waist Hip Ratio (WHR) 1.2 5.2 15.6 1.9 -0.5 1.7 0.4 -3.9 0.2 -1.8 -3.5 -2.3 -2.9
Systolic Blood Pressure 0.7 3.8 17.8 -0.1 -2.1 -2.6 0.3 -0.6 -0.5 1.4 -4.2 0.6 -2.3
Smoking Status 0.9 2.3 5.1 -1.9 0.3 -1.8 -2.0 0.1 2.0 2.3 -1.2 0.2 -0.9
Allergy or Eczema 1.1 2.9 7.6 2.0 1.3 -1.1 -1.9 -1.2 2.8 -0.1 -0.9 2.2 1.9
Cardiovascular Disease 1.8 5.9 21.8 -0.3 -3.4 -1.7 -0.2 -3.2 0.2 2.0 -4.7 -0.4 -2.8
Hypothyroidism (self reported) 1.9 4.4 14.2 0.4 0.7 -1.8 -1.6 -1.3 1.2 -0.6 -3.8 -3.0 -3.3
Respiratory disease 1.4 3.0 14.5 0.5 -2.0 0.5 -1.2 -3.8 2.7 1.4 -0.5 0.3 -0.3
Type 2 Diabetes (T2D) (2018) 1.6 3.0 10.6 0.4 1.1 -0.6 -2.0 -2.5 2.5 0.2 -3.2 0.5 -0.9
Lung FEV1/FVC ratio 0.7 3.6 10.0 -2.6 -2.2 -0.2 2.8 1.5 -3.2 0.3 1.7 -0.6 0.2
Lung FVC 1.4 7.1 48.9 -0.9 2.8 -1.6 -0.4 7.0 -1.9 1.2 0.4 -2.1 -1.2
Neuroticism 0.6 1.5 9.4 -1.4 0.1 -3.1 -0.5 -0.2 0.2 -0.3 -1.3 -0.3 -1.3
Chronotype (morning person) 0.4 0.9 2.2 -0.8 1.5 -1.5 -0.2 0.1 -0.4 -0.8 -1.0 -1.0 -0.8
Hair Pigment 0.1 3.0 8.8 -3.0 -1.5 1.4 2.3 -1.4 -1.8 -0.7 2.2 -0.4 0.9
Tanning 0.1 0.9 3.0 0.5 -0.9 -1.7 1.2 1.0 -1.3 0.1 0.7 0.3 0.2
Hand grip strength (left) 1.0 2.7 10.8 -2.0 -0.6 -3.3 2.1 0.7 -2.4 1.1 0.2 0.6 -0.1
Number of treatments/medications taken 0.6 1.1 2.8 -0.8 -0.1 -0.0 -1.4 -0.5 1.6 1.2 -1.7 -0.1 -1.1
Average weekly spirits intake 0.3 0.4 0.9 -0.7 0.2 0.8 1.0 -0.1 -1.0 -0.3 0.4 0.8 0.7
Sensitivity / hurt feelings 0.5 0.8 2.8 -0.4 1.6 -1.7 -0.6 0.5 0.2 -0.3 -0.9 1.0 -0.2
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.6 -0.5 -0.7 -0.7 1.1 0.5 0.2 -1.0 0.3 1.3 1.2
Hearing difficulty/problems: Yes 0.3 0.5 2.2 -0.4 -0.4 -1.2 -0.2 -0.6 -0.2 1.5 0.4 0.4 0.6
Relative age of first facial hair 0.5 1.1 4.8 1.3 -2.2 0.3 0.7 -0.2 -0.2 0.1 -0.6 -1.4 -1.1
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 4.7 0.4 1.6 -2.2 -0.3 1.4 0.6 1.0 -0.3 1.8 1.1
Ever used hormone-replacement therapy (HRT) 0.2 0.3 1.1 0.2 0.4 1.0 -0.1 -0.1 -0.1 0.5 0.2 1.1 0.5
Ever had hysterectomy (womb removed) 0.3 0.4 2.6 -0.4 0.6 -0.4 0.0 -0.4 -0.5 1.6 -0.1 0.1 -0.5
Systolic blood pressure, automated reading 1.6 4.5 21.5 -0.4 -1.7 -1.1 0.4 -2.3 -0.3 0.6 -4.6 -1.3 -3.4
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.4 1.3 -0.2 0.1 0.1 -0.1 0.4 0.0 0.0 1.5 1.1
Angina 1.7 2.2 10.8 -0.1 0.2 -2.4 -0.8 -0.1 0.2 0.3 -3.3 -0.5 -2.2
Medication for hormone replacement therapy 1.1 1.2 4.2 1.1 1.3 -1.1 -0.8 2.0 0.4 1.7 -0.5 0.1 0.1
Vitamin and mineral supplements 1.5 2.0 4.8 -1.3 0.9 1.1 -1.7 -1.5 1.4 -0.4 -2.2 -1.2 -1.7
Supplements: Zinc 1.2 1.3 7.1 1.4 -0.0 0.2 -1.1 -0.0 0.7 2.7 -0.9 -0.5 -0.8
Medication: Co-codamol 0.5 0.5 1.1 0.5 0.9 0.9 -0.5 0.7 0.4 0.7 -1.0 -0.2 -1.0
Medication: Metformin 2.2 3.1 10.1 -0.2 -0.1 -0.1 -2.4 -2.9 3.2 1.6 -2.0 0.3 -0.6
Diabetes (father) 0.3 0.4 1.7 -0.4 -0.0 1.0 0.4 -1.3 -0.1 -0.9 0.4 0.2 0.0
Diabetes (mother) 3.3 4.2 12.6 -1.8 -0.9 -1.1 -1.1 -1.9 1.0 -1.4 -3.3 -2.4 -3.5
Severe depression (siblings) 0.6 0.6 4.5 0.6 -0.3 0.5 -0.1 -2.1 0.7 0.2 -0.2 0.7 0.3
Pack years adult smoking proportion 0.4 0.6 1.6 -1.1 -1.3 0.7 1.1 0.6 0.0 0.2 0.7 0.4 0.6
Impedance of leg (right) 0.8 3.8 10.2 1.6 0.3 3.2 -0.6 -1.9 0.4 -0.2 -2.4 -2.7 -2.8
Leg fat-free mass (left) 0.6 3.3 10.9 -1.7 0.4 -3.2 0.2 0.5 0.7 -0.1 1.6 3.3 2.3
Trunk fat percentage 0.7 2.9 8.5 -1.4 -1.0 2.8 0.1 -2.9 1.0 -2.0 -1.2 -1.1 -1.4
Hand grip strength (right) 0.7 1.9 6.8 -0.9 -0.7 -2.6 1.8 0.8 -2.1 1.2 0.4 0.8 -0.1
Townsend deprivation index at recruitment 1.6 2.3 6.2 0.8 0.5 1.7 -2.5 -0.9 2.2 2.1 -0.5 1.5 0.1
Current tobacco smoking 1.4 2.3 11.3 -3.4 -0.7 -1.0 -1.0 0.5 1.6 1.7 -1.1 -0.7 -1.4
Average weekly fortified wine intake 0.6 0.7 2.1 -1.5 -1.0 -0.2 1.2 -0.7 -1.1 -0.2 -0.1 -0.4 -0.5
Maternal smoking around birth 1.0 1.4 5.2 -1.2 -2.3 -0.2 1.8 -1.6 -0.6 -0.7 -0.1 -0.5 -0.3
Fed-up feelings 0.4 0.7 2.7 -0.8 -1.1 0.1 -0.6 -0.5 1.0 1.6 -0.4 0.5 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 2.2 -0.5 0.2 -1.5 -0.1 0.2 0.3 -0.6 -0.6 0.6 -0.1
Relative age voice broke 2.0 3.0 9.4 0.4 -2.2 -0.2 0.3 -0.9 -0.1 0.8 -2.3 -3.0 -3.1
Taking other prescription medications 1.6 2.5 6.4 -1.5 0.5 -1.0 -1.7 -1.8 2.2 -0.4 -2.5 -1.0 -1.7
Age when periods started (menarche) 0.9 2.2 8.5 2.9 -0.3 2.5 0.7 0.3 -1.2 0.7 1.7 0.6 1.3
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 4.9 -1.5 -0.1 -2.2 0.1 -0.4 -0.1 1.4 -0.7 -0.2 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 6.5 0.6 -0.9 -0.4 -1.2 -0.6 0.7 2.5 -0.9 -0.0 -0.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 5.2 -0.3 -0.4 -0.4 2.3 0.5 -2.0 -1.6 2.0 0.2 1.2
Qualifications: CSEs or equivalent 1.4 1.8 8.2 -0.9 -2.9 -1.3 0.5 -1.8 0.2 1.7 0.9 0.6 0.2
Serious illness, injury or assault to yourself 0.9 1.1 4.1 1.2 2.0 -0.2 -0.6 1.2 0.0 -0.3 -0.1 1.9 0.6
High blood pressure 1.2 3.3 11.5 0.1 -1.8 -2.0 -0.5 -0.9 -0.3 2.6 -3.4 -0.1 -2.5
Hayfever, allergic rhinitis or eczema 1.2 2.6 7.9 1.6 1.4 -1.0 -2.3 -0.3 2.8 -0.0 -0.5 2.0 1.7
Multivitamins +/- minerals 1.5 1.9 4.4 1.5 -1.5 -1.2 1.7 1.3 -1.0 0.2 2.1 1.1 1.1
Stomach or abdominal pain in last month 1.2 1.4 3.7 1.9 0.1 -0.7 -1.0 1.0 1.1 1.8 0.8 1.4 1.1
Supplements: Glucosamine 0.5 0.7 2.8 -0.5 -1.7 0.3 0.8 -1.1 -0.3 0.2 0.9 0.9 0.6
Diverticular disease/diverticulitis (self-reported) 1.9 2.3 4.6 1.9 -0.1 0.5 1.2 1.8 -1.0 -0.6 2.0 2.2 1.9
Medication: Atenolol 0.7 0.8 3.1 -1.2 -0.5 -1.8 0.4 -0.1 -0.8 -0.4 -1.4 0.5 -0.6
Medication: Levothyroxine sodium 4.0 6.7 17.7 -1.5 -0.4 -2.5 -2.4 -1.0 2.5 0.6 -4.2 -3.4 -4.0
Sitting height 0.6 4.0 13.2 1.2 1.9 -3.6 -1.2 1.8 1.2 0.9 0.9 3.1 2.1
Chronic bronchitis/emphysema (father) 0.5 0.6 2.6 -0.6 0.4 0.6 -0.1 -1.6 0.2 -0.8 -0.6 -0.6 -0.9
High blood pressure (mother) 0.4 0.5 1.0 1.0 0.5 -0.4 -1.0 -0.8 0.3 0.9 -0.2 0.9 -0.4
Body mass index (BMI) 0.4 1.6 9.4 -3.1 -1.6 0.7 1.2 -1.0 -0.6 -0.3 0.4 0.0 -0.7
Impedance of leg (left) 0.7 3.5 10.1 2.2 -0.2 3.2 -0.0 -2.3 -0.2 -0.9 -1.8 -2.5 -2.0
Leg predicted mass (left) 0.6 3.3 11.2 -1.6 0.4 -3.1 0.3 0.4 0.6 -0.2 1.7 3.4 2.4
Trunk fat mass 0.4 1.7 6.3 -2.0 -1.0 1.2 0.4 -2.5 0.8 -1.7 -0.6 -0.2 -0.8
Waist circumference 0.5 1.7 7.5 -2.1 -1.3 0.6 0.9 -2.7 0.2 -1.0 -0.8 0.2 -1.0
Number of incorrect matches in round 0.5 0.8 2.4 -0.3 -0.4 -0.6 0.9 1.3 -1.5 0.2 1.2 -0.7 0.3
Past tobacco smoking 1.2 2.2 7.6 0.2 -2.8 1.3 1.5 -1.4 -0.2 -2.2 0.6 -1.7 -0.5
Alcohol usually taken with meals 0.2 0.4 1.0 0.7 -0.9 0.3 -0.4 0.8 -0.1 1.0 -0.1 0.8 0.3
Nervous feelings 0.3 0.5 1.3 0.8 0.5 -0.8 -0.1 0.4 -0.5 -0.5 -0.7 -1.2 -1.0
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 6.5 -2.1 -2.5 0.0 -0.1 -1.4 0.8 0.1 -0.5 -1.1 -0.8
Hearing difficulty/problems with background noise 0.2 0.4 2.4 0.2 -0.5 -1.5 -0.5 -0.5 0.4 0.0 -0.2 -0.5 -0.4
Hair/balding pattern: Pattern 2 1.0 1.3 2.7 -1.2 0.5 -1.6 -1.7 -1.3 1.6 -0.0 -0.9 -0.3 -0.9
Had menopause 0.8 1.0 3.7 -0.1 -0.3 0.1 1.5 -0.2 -0.9 -1.9 -0.4 -1.7 -0.2
Had other major operations 1.8 2.2 3.6 -0.9 1.6 -1.0 -1.9 1.0 1.7 1.9 1.4 1.4 1.5
Forced vital capacity (FVC) 1.4 5.4 29.3 1.3 3.5 -2.1 -1.1 5.4 -0.9 1.6 0.7 0.7 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 4.2 0.4 -1.0 -0.8 -0.7 0.0 0.6 2.0 -0.5 -0.2 -0.3
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 3.2 -0.3 0.7 -1.3 -0.6 0.0 0.6 0.3 0.0 1.8 0.7
Qualifications: None of the above 0.6 1.4 4.7 -1.5 -0.7 2.2 1.4 0.3 -1.4 -1.3 0.4 -0.3 -0.2
Financial difficulties in last 2 years 0.2 0.3 1.1 -0.6 0.2 0.9 0.3 -0.7 0.3 -0.5 0.1 1.0 0.4
Mouth/teeth dental problems 0.6 1.0 3.9 1.0 0.9 -1.1 0.5 2.0 -0.6 0.1 -0.1 1.2 0.8
Heart attack 1.1 1.4 4.7 0.6 0.2 -2.2 -0.8 1.5 -0.3 1.8 -1.4 0.9 0.2
Allergy 1.5 3.5 15.6 -1.4 -0.4 1.0 2.8 1.4 -4.0 -0.3 0.7 -1.9 -1.6
Pain all over the body in last month 1.0 1.1 3.7 -1.3 -1.9 0.6 0.9 -1.2 0.2 0.2 -0.7 -0.8 -1.3
Diabetes (self-reported) 1.5 2.3 6.2 1.1 1.7 0.3 -2.0 -1.4 2.5 0.4 -2.4 0.4 -0.5
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 2.4 -0.8 -1.6 -0.0 1.0 -1.2 0.3 -1.4 -0.1 -0.4 0.1
Medication: Ramipril 1.5 1.9 7.5 0.2 -1.6 -0.8 -0.9 -1.3 1.4 0.1 -2.7 -1.1 -1.7
Medication: Simvastatin 1.9 2.8 13.3 0.5 -1.7 1.2 -0.2 -1.5 0.9 -0.0 -3.6 -1.8 -2.0
Fluid intelligence score 0.8 1.6 7.1 2.7 0.4 0.3 -1.4 0.4 1.6 0.4 -1.4 -1.1 -0.9
Illnesses of siblings 2.4 3.4 9.6 -0.7 0.4 -0.2 2.2 1.9 -1.4 -2.1 2.7 1.1 3.1
Neuroticism score 0.2 0.5 2.4 -0.5 0.3 -1.6 -0.6 -0.2 0.6 -0.3 -0.8 0.2 -0.7
Weight 0.3 1.4 5.3 -2.3 -0.6 -1.3 0.9 -1.0 0.1 -0.8 0.7 1.7 0.8
Impedance of arm (right) 1.1 5.2 12.5 3.5 2.1 3.3 -2.1 -1.9 2.3 -2.5 -1.7 -0.9 -0.4
Arm fat percentage (right) 0.6 2.3 6.3 -1.8 -1.0 2.5 0.2 -2.5 0.8 -1.5 -0.9 -0.8 -1.5
Trunk fat-free mass 0.9 5.0 23.8 -2.1 -0.2 -4.9 0.6 0.8 -0.1 1.5 1.8 3.3 2.1
Hip circumference 0.3 1.2 8.0 -2.8 -0.9 -0.5 0.3 -1.0 0.5 -0.1 0.7 0.9 0.2
Time employed in main current job 0.6 0.7 1.8 -0.9 -0.6 -0.8 0.9 -0.1 -0.8 -1.3 1.1 0.3 0.6
Alcohol intake versus 10 years previously 0.3 0.5 0.9 -0.6 -0.8 0.8 0.5 -0.5 -0.9 -0.6 0.9 0.5 0.3
Father’s age at death 0.7 1.0 4.1 -0.6 -1.1 0.3 0.4 -1.3 0.4 -0.9 -0.7 -2.0 -0.9
Worrier / anxious feelings 0.2 0.3 1.0 0.4 1.0 -0.7 -0.2 0.8 -0.2 -0.7 -0.6 0.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 3.5 -0.5 0.4 0.6 -1.2 -0.1 1.4 0.7 -0.9 1.9 -0.0
Falls in the last year 0.7 1.0 4.6 -0.4 -0.3 0.9 -0.9 -2.2 1.0 0.4 -1.3 0.1 -0.6
Hair/balding pattern: Pattern 3 0.3 0.4 1.3 -0.7 0.3 -0.3 -1.2 0.5 1.0 0.4 0.1 -0.5 -0.4
Number of live births 1.6 2.3 7.0 -0.1 -1.7 0.2 1.2 -2.7 -0.5 -0.9 -1.7 -2.2 -1.7
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 22.3 0.5 2.2 -2.1 -0.0 4.7 -1.7 1.2 1.6 1.0 0.9
Pulse rate 1.9 3.3 14.6 0.5 -1.4 3.8 0.8 -0.4 -1.1 0.3 -0.5 -3.0 -2.2
Happiness 0.7 0.9 2.0 -0.1 -0.9 0.5 0.7 1.4 -0.7 1.4 1.1 0.8 0.8
Noisy workplace 0.3 0.4 1.7 0.2 0.2 0.6 0.5 0.1 -0.3 -0.4 0.9 1.3 0.8
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.1 0.7 -0.4 -2.0 -1.6 -1.4 1.2 1.8 -0.7 -0.6 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 5.2 1.0 1.6 -0.3 -0.6 1.3 -0.1 0.4 1.5 2.3 1.9
Mouth/teeth dental problems: Dentures 1.3 2.2 4.4 -2.1 -1.6 1.7 -0.8 -1.2 1.0 1.6 -0.6 -1.8 -1.6
Asthma 1.6 3.1 14.2 0.4 -1.9 -0.2 -1.5 -3.8 2.8 0.8 -0.9 -1.0 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 1.9 -0.1 0.4 0.8 0.1 0.4 -0.4 -0.1 0.5 1.4 -0.1
Medication: Cholesterol lowering 1.7 2.7 15.2 0.3 -1.1 -1.8 -0.6 -1.1 0.8 0.1 -3.9 -1.2 -1.8
Depression (self-reported) 0.8 0.9 2.4 1.5 1.4 -1.2 -0.1 0.7 -0.0 -1.1 -1.1 -0.1 -0.5
Medication: Lansoprazole 2.6 2.9 9.3 0.1 0.7 1.0 -2.8 -0.7 3.0 1.7 -2.0 -0.3 -1.8
Prospective memory result 2.3 2.8 6.3 -1.3 -2.2 2.4 2.5 -0.1 -1.6 -1.8 1.7 -0.9 0.0
Lung cancer (father) 0.5 0.6 3.0 0.3 -0.1 -0.6 0.1 0.7 -0.9 1.7 0.5 -0.8 -0.3
Illnesses of mother 1.5 1.9 5.7 1.1 -0.0 0.7 0.6 1.8 -0.8 0.5 2.4 1.6 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 12.1 0.2 1.8 -3.0 -0.7 3.5 -1.0 1.3 1.2 1.3 0.8
Pulse wave Arterial Stiffness index 1.0 1.2 2.0 1.3 -0.2 0.7 -1.3 -1.0 1.1 1.2 -1.3 -0.3 -1.4
Impedance of arm (left) 1.3 6.2 15.2 3.9 2.9 3.2 -2.4 -1.5 2.4 -2.8 -2.1 -1.2 -0.6
Arm fat mass (right) 0.3 1.2 4.9 -2.2 -0.9 0.7 0.7 -1.8 0.2 -1.1 0.0 0.5 -0.4
Trunk predicted mass 0.9 5.0 23.8 -2.0 -0.1 -4.9 0.6 0.8 -0.1 1.4 1.8 3.4 2.1
Standing height 0.6 5.6 21.8 1.4 1.5 -4.7 -0.4 -0.3 1.4 -1.0 1.1 3.8 3.3
Length of working week for main job 2.5 2.7 10.0 -0.2 -1.6 -0.1 1.6 0.7 -0.8 -1.1 3.2 1.8 2.6
Exposure to tobacco smoke at home 0.4 0.5 2.0 -0.9 -0.2 1.4 0.7 0.0 -0.6 0.2 0.9 -0.3 0.3
Breastfed as a baby 0.7 0.9 3.8 0.0 -0.0 -0.4 -1.0 -1.9 0.9 0.6 -1.1 -0.9 -0.6
Tense / ‘highly strung’ 0.2 0.3 0.9 -0.1 -0.6 -1.0 0.0 -0.4 0.2 0.0 0.4 0.9 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 4.5 0.6 1.1 -2.1 -0.2 2.1 0.0 0.9 -0.3 2.1 0.5
Hair/balding pattern: Pattern 4 0.2 0.6 1.8 0.7 0.7 1.1 -0.1 1.3 -0.6 1.1 0.1 0.3 0.0
Birth weight of first child 0.8 1.5 3.3 -1.4 1.8 -0.2 -1.4 0.7 1.7 0.3 1.5 0.9 1.3
Peak expiratory flow (PEF) 0.6 1.4 3.7 -0.6 1.1 -1.9 -0.4 1.9 -0.3 1.2 0.9 1.1 1.1
Pulse wave reflection index 0.5 0.6 1.6 1.3 -0.4 -1.1 -0.6 -0.6 0.6 0.8 0.1 0.9 0.1
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.9 0.1 0.8 0.5 0.8 0.6 -1.2 0.9 1.4 1.7 0.6
Loud music exposure frequency 2.3 2.5 8.5 -1.1 -1.0 0.1 0.9 0.8 -0.6 0.1 2.9 2.4 2.5
Qualifications: O levels/GCSEs or equivalent 1.7 2.7 5.7 2.0 1.3 -1.8 -2.4 0.5 1.5 2.3 -0.2 1.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.2 0.3 0.0 -0.7 0.6 -1.1 -0.8 -0.6 1.1 -0.1 0.7
Blood clot in the leg (DVT) 1.4 1.7 9.1 -0.2 0.2 -1.5 -2.0 0.2 3.0 0.8 -0.8 0.5 0.7
Medication: Paracetamol 0.8 1.3 6.0 0.8 0.7 0.4 -0.2 2.5 -0.4 1.6 1.3 0.9 0.1
Headache pain in last month 1.2 2.1 6.6 2.6 -0.8 1.5 -0.9 0.1 0.9 2.0 1.3 1.8 1.2
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 14.4 0.7 1.7 1.8 -0.0 0.9 -0.1 -0.4 3.8 1.7 2.6
Glaucoma (self-reported) 0.8 0.9 3.7 -1.0 1.0 -0.8 0.7 -0.6 -1.2 -1.9 -0.4 -0.1 -0.0
Gout (self-reported) 1.4 2.0 6.0 -0.6 0.1 -2.2 -0.1 0.4 -0.2 -0.7 -2.4 -2.0 -2.0
Hypothyroidism/myxoedema (self-reported) 2.4 4.6 12.9 -0.7 -0.1 -1.4 -1.6 -1.0 1.6 0.4 -3.5 -3.6 -3.6
Medication: Amlodipine 0.9 1.2 3.5 1.2 0.1 0.0 -1.2 1.9 0.5 1.6 -1.1 0.3 -1.2
Medication: Ventolin 100micrograms inhaler 1.5 2.0 11.4 -0.4 -1.7 -0.6 0.9 -3.4 0.6 -1.6 0.1 -1.1 -0.2
Birth weight 1.2 2.7 14.7 -1.7 3.8 -1.1 -0.4 1.8 0.2 -2.0 -0.0 -0.3 0.6
Chronic bronchitis/emphysema (mother) 0.9 1.0 4.8 0.4 0.2 0.1 -0.1 -2.2 0.9 -1.8 -0.8 -0.2 -0.9
High blood pressure (siblings) 1.0 1.5 5.6 0.6 0.2 -0.7 -1.0 -0.7 0.3 1.6 -1.8 -1.0 -2.4
Forced vital capacity (FVC), Best measure 1.0 3.8 14.3 0.8 2.6 -3.3 -1.2 3.8 -0.6 1.2 0.7 1.0 0.4
Body fat percentage 0.8 3.1 8.5 -2.0 -1.2 2.9 0.4 -2.9 0.5 -1.8 -1.2 -1.2 -1.7
Leg fat percentage (right) 1.0 3.7 7.7 -2.8 -1.5 2.7 0.8 -2.6 -0.3 -0.9 -1.2 -1.5 -2.7
Arm fat-free mass (right) 0.7 3.6 15.1 -2.3 -0.6 -3.9 1.3 0.8 -0.7 1.1 1.6 2.5 1.6
Exposure to tobacco smoke outside home 1.7 2.3 13.0 1.0 -0.9 3.6 1.7 0.2 -1.0 -1.1 0.8 -1.1 -0.8
Comparative body size at age 10 0.9 2.5 6.1 -2.5 0.4 -0.4 2.3 1.2 -2.3 -2.5 0.5 0.2 0.7
Number of full brothers 0.7 0.9 1.5 0.3 0.7 0.8 -1.2 -1.2 1.2 1.1 -0.8 -0.8 -0.8
Worry too long after embarrassment 1.0 1.6 9.7 -2.2 0.8 -3.1 -0.5 0.7 0.1 -0.0 -0.6 0.2 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 3.6 1.7 1.9 -0.5 1.5 1.1 -1.2 -1.7 1.1 1.9 1.7
Wheeze or whistling in the chest in last year 1.5 2.7 6.8 -1.7 -2.6 0.4 -1.1 -2.4 2.4 2.0 0.1 0.3 -0.2
Number of children fathered 0.3 0.3 1.0 -1.0 -0.6 -1.0 0.5 -0.0 -0.4 0.2 -0.2 -0.2 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 -0.3 -0.1 -0.7 -0.1 0.6 0.1 -0.6 0.0 -0.4 0.1
Age at first live birth 1.4 2.4 4.7 2.2 0.7 -0.0 1.5 1.7 -1.1 -1.8 1.9 1.4 2.0
Pulse wave peak to peak time 1.1 1.3 2.5 -1.4 0.2 -1.1 1.4 0.9 -1.2 -1.2 1.3 0.5 1.6
Health satisfaction 0.6 0.8 3.4 -0.0 1.8 0.8 0.5 1.5 -0.9 0.1 -0.2 0.4 0.1
Shortness of breath walking on level ground 2.4 2.8 6.5 0.4 0.2 0.8 2.0 0.3 -1.6 -1.6 2.6 2.4 2.5
Qualifications: College or University degree 0.4 1.1 4.1 2.0 0.7 -0.5 -1.7 0.7 1.7 0.2 0.1 -0.3 0.3
Eye problems/disorders: None of the above 0.2 0.3 1.9 -0.2 0.1 0.5 -0.0 -0.2 -1.4 0.4 0.3 0.5 -0.1
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.8 -1.9 -0.2 -1.8 -0.4 -1.2 1.1 -0.7 -0.8 0.0 0.3
Emphysema/chronic bronchitis 1.1 1.2 4.5 -0.2 -1.3 2.1 1.2 -0.2 -0.8 -0.3 1.4 0.9 1.2
Medication for pain relief, constipation, heartburn 0.6 1.0 3.5 1.0 1.0 -0.2 0.3 -0.3 -0.6 -1.9 1.3 -0.0 1.5
Neck or shoulder pain in last month 0.4 0.6 1.5 -1.2 0.3 -0.9 -1.1 0.3 1.1 1.0 0.2 0.5 -0.2
Medication: Blood pressure 1.2 2.0 5.9 -0.9 -1.3 -1.8 -0.7 0.8 0.2 1.8 -2.4 -0.6 -2.0
Angina (self-reported) 1.7 2.3 11.0 -0.2 -0.0 -2.4 -0.7 -0.3 0.1 0.5 -3.3 -0.6 -2.2
Migraine (self-reported) 0.2 0.2 1.0 -0.3 -0.1 -0.5 -0.1 -0.3 -0.5 -0.4 -0.6 1.0 -0.4
Medication: Ibuprofen 0.3 0.3 0.9 -0.9 0.5 1.0 0.1 0.3 -0.5 -0.5 -0.0 0.1 -0.9
Medication: Allopurinol 1.8 2.4 5.7 -1.2 1.4 -2.4 0.0 2.3 -0.9 -0.3 -1.9 -1.7 -1.3
Medication: Omeprazole 1.2 1.4 3.6 0.5 0.1 0.7 1.1 -0.3 -0.5 -1.5 1.7 1.7 1.9
Medication: Seretide 50 evohaler 0.2 0.3 1.5 -1.2 0.0 -0.6 -0.1 0.0 -0.0 -0.3 0.7 -0.3 0.2
Mean time to correctly identify matches 0.1 0.3 0.7 -0.3 -0.0 0.6 0.3 0.1 -0.8 -0.8 -0.7 0.6 -0.3
Heart disease (mother) 2.3 2.8 7.1 -0.5 -2.2 -0.6 0.6 -2.7 0.6 -1.1 -1.9 -2.3 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 5.6 -0.2 0.6 0.5 0.3 0.5 0.1 -0.4 1.1 2.4 1.5
Whole body fat mass 0.4 1.8 5.8 -2.4 -1.5 1.0 0.8 -2.4 0.4 -1.2 -0.3 -0.1 -0.8
Leg fat mass (right) 0.4 1.6 8.0 -2.8 -1.4 0.9 1.0 -1.7 -0.1 -0.7 -0.2 -0.0 -1.1
Arm predicted mass (right) 0.8 4.1 15.7 -2.3 -0.7 -4.0 1.7 0.7 -1.0 0.7 1.8 2.7 1.9
Pulse rate, automated reading 1.2 3.8 26.5 0.4 -0.7 5.2 1.2 -0.8 -1.0 -0.5 0.1 -2.5 -1.2
Alcohol intake frequency. 0.5 1.2 3.8 1.8 0.1 2.0 -0.1 0.2 -0.3 -1.4 1.1 1.0 0.7
Comparative height size at age 10 0.6 3.1 22.2 -1.1 0.8 -4.7 0.6 -0.8 0.6 -1.7 -0.7 1.3 0.8
Number of full sisters 1.8 2.2 5.2 -0.1 0.4 0.3 -2.1 -0.6 1.6 2.3 -2.1 -1.0 -2.0
Suffer from ‘nerves’ 0.3 0.4 2.0 -0.4 0.3 -0.5 0.5 0.2 -0.4 -1.4 0.7 0.6 0.7
Overall health rating 0.8 1.6 3.6 -1.0 -0.7 1.6 -1.1 -1.2 1.8 0.6 -1.9 -0.4 -1.5
Chest pain or discomfort 1.4 2.0 5.8 -0.6 0.4 -0.5 -2.2 -1.4 2.4 1.6 -1.6 1.2 -0.4
Had major operations 2.2 2.6 4.5 1.6 1.6 -1.3 -2.0 1.8 2.1 1.2 -0.4 2.1 1.1
Age at last live birth 1.2 1.8 4.9 2.1 0.2 -0.3 0.5 1.0 -0.6 -0.8 1.6 1.9 2.2
Family relationship satisfaction 0.5 0.7 3.6 1.2 0.2 -0.4 -0.0 0.6 -0.1 0.7 -0.1 1.9 0.8
Leg pain on walking 1.2 1.6 6.4 0.6 0.4 0.2 0.8 0.8 -0.4 0.7 1.5 2.5 2.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 4.4 0.6 0.2 -1.3 -1.2 -1.0 1.0 2.1 -1.7 -0.8 -1.4
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.6 -0.1 0.1 0.4 0.8 -0.0 -0.4 -1.2 0.9 0.8 0.6
Illness, injury, bereavement, stress in last 2 years 2.8 3.5 13.4 -1.4 -2.9 0.4 0.9 -0.7 -0.6 0.8 -0.7 -3.7 -2.8
Medication: Aspirin 1.3 1.7 8.8 1.4 -0.2 -0.3 -1.1 -0.3 1.2 1.7 -3.0 0.2 -0.9
Supplements: Vitamin C 0.7 0.8 3.2 0.9 -1.2 -1.1 0.8 -0.1 -0.7 1.8 -0.1 -0.2 0.3
Knee pain experienced in last month 0.5 0.7 2.4 -0.9 -0.1 0.3 -0.4 -0.6 0.8 1.2 0.7 1.6 0.9
Hypertension (Self-reported) 1.1 2.9 9.9 -0.2 -1.9 -2.1 -0.2 -0.9 -0.6 2.1 -3.1 -0.2 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 3.5 0.1 -1.9 1.2 0.0 -1.8 1.4 -0.2 0.2 -0.9 -0.2
Illnesses of father: Heart disease 1.3 1.8 7.7 0.3 -1.2 -0.6 -0.8 0.1 1.2 0.8 -2.8 -0.9 -2.1
Illnesses of siblings: Diabetes 1.1 1.4 3.2 1.6 -0.5 1.4 -1.1 -1.8 1.0 0.7 -1.3 -0.4 -1.1
Smoking status: Previous 1.2 1.8 6.6 0.4 2.6 -1.6 -1.3 1.1 -0.3 1.8 -0.6 1.1 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 2.0 8.5 0.8 0.6 -2.9 -1.2 0.4 1.6 0.0 0.8 2.0 1.2
Whole body fat-free mass 0.8 4.5 18.6 -1.9 -0.1 -4.3 0.7 0.8 -0.1 0.8 2.0 3.5 2.4
Leg fat-free mass (right) 0.8 4.1 13.6 -1.1 0.2 -3.4 0.5 0.5 0.3 -0.3 2.2 3.7 3.0
Arm fat percentage (left) 0.6 2.2 6.7 -1.7 -0.6 2.6 0.1 -2.2 0.8 -1.8 -1.0 -0.9 -1.5
Average weekly red wine intake 1.3 1.9 4.7 0.7 0.9 -0.6 -2.1 0.2 1.4 1.6 -1.9 -0.5 -2.2
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.2 -0.1 -0.8 -1.4 1.1 -0.0 -0.7 -0.2 1.2 -0.0 1.5
Mood swings 0.2 0.4 2.3 1.5 -0.5 0.1 0.4 -0.2 0.3 -0.4 -0.6 0.5 -0.3
Loneliness, isolation 0.8 1.0 5.2 -0.6 -1.2 -0.0 -0.0 -2.3 1.1 -0.7 -1.2 0.4 -0.3
Long-standing illness, disability or infirmity 2.1 3.1 10.9 0.4 0.7 -0.2 -2.2 -1.6 3.1 0.5 -3.3 -0.0 -1.6
Ever had bowel cancer screening 0.3 0.3 0.9 0.9 0.1 0.0 -0.6 -0.7 0.5 0.1 -1.0 -0.4 -0.3
Diabetes diagnosed by doctor 2.2 3.6 10.4 0.5 1.0 -0.4 -2.4 -2.8 3.0 0.9 -3.2 0.1 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.3 6.1 2.5 0.7 2.1 0.3 -0.3 -0.1 -1.2 -0.7 -0.4 0.1
Friendships satisfaction 0.4 0.5 2.1 1.1 -0.7 -0.2 -0.0 -0.6 -0.5 1.4 0.4 0.3 0.0
Qualifications: nursing, teaching 0.4 0.7 1.5 1.2 -0.1 -1.2 0.0 0.8 0.3 1.0 0.5 0.6 1.2
Commuting to job workplace: Walk 0.9 1.0 3.2 0.1 1.4 -0.7 -1.8 -0.4 1.3 0.5 -1.5 -0.1 -0.5
Eye problems/disorders: Cataract 0.3 0.3 1.5 0.5 0.2 0.6 -0.4 0.9 1.2 0.3 0.0 0.1 0.0
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.2 0.9 0.8 0.7 -0.8 1.5 0.4 1.3 0.9 0.1 0.0
Medication for cholesterol 1.0 1.6 7.8 -0.4 1.1 1.6 0.7 0.6 -1.2 -0.9 2.8 -0.1 1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 0.3 -0.3 -0.7 0.2 0.7 0.2 0.3 -0.2 0.1 -0.2
Back pain experienced in last month 0.4 0.6 1.4 -0.9 -0.1 0.1 -0.1 0.8 0.1 0.9 1.2 1.2 1.0
Mineral and other dietary supplements 0.8 1.0 5.7 1.0 2.4 0.4 -0.0 1.5 -1.0 -0.5 -0.1 -0.0 -0.2
Breast cancer (self-reported) 1.9 2.2 8.8 2.3 3.0 0.5 -1.4 2.2 0.5 0.7 0.0 -0.4 -0.2
Asthma (self-reported) 1.6 3.2 12.8 0.2 -1.6 -0.2 -1.7 -3.6 2.9 0.9 -1.2 -1.2 -1.2
Osteoporosis (self-reported) 0.9 1.1 4.7 -0.7 1.6 -1.0 -0.1 -0.0 -0.0 -2.2 0.4 1.0 0.6
Osteoarthritis (self-reported) 0.3 0.4 3.0 -1.7 0.2 0.8 0.6 0.3 -0.3 -0.2 -0.0 -0.3 -0.3
Medication: Aspirin 1.4 1.8 9.6 1.1 -0.0 -0.4 -1.2 -0.1 1.1 1.8 -3.1 -0.1 -1.1
Medication: Gliclazide 0.9 1.0 5.2 -0.3 0.6 -0.9 -0.5 -0.4 0.6 0.8 -2.3 -0.8 -1.2
Illnesses of father: None of the above (group 1) 1.1 1.4 5.2 0.0 1.1 -0.4 0.6 1.3 -1.6 0.3 2.3 0.3 1.6
Smoking status: Current 1.0 1.6 8.2 -2.9 -0.8 -1.0 -0.6 0.6 1.2 1.5 -0.7 -0.4 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 10.6 0.3 0.7 -0.7 -0.0 3.3 -1.5 0.6 1.7 0.3 0.0
Whole body water mass 0.8 4.7 19.7 -1.9 -0.1 -4.4 0.7 0.8 -0.0 0.8 2.0 3.5 2.4
Leg predicted mass (right) 0.8 4.1 14.0 -1.1 0.2 -3.4 0.5 0.6 0.3 -0.3 2.2 3.7 3.0
Arm fat mass (left) 0.3 1.2 5.6 -2.4 -1.0 0.7 0.7 -1.7 0.3 -1.2 -0.1 0.3 -0.5
Number of self-reported non-cancer illnesses 0.9 1.5 6.0 -0.5 -0.8 -1.7 -0.0 -1.7 1.1 0.1 -2.4 0.8 -0.8
Average weekly champagne plus white wine intake 0.4 0.6 2.5 -1.5 0.3 -1.6 -0.1 -0.8 -0.3 -0.1 -0.3 -0.4 -0.3
Miserableness 0.7 1.3 6.3 0.6 0.8 -1.1 -0.9 1.3 0.9 0.4 0.3 2.5 0.7
Guilty feelings 0.2 0.3 1.0 0.1 -0.7 0.3 0.2 -1.0 -0.7 -0.2 -0.4 -0.4 -0.5
Wears glasses or contact lenses 0.3 0.4 1.4 0.7 0.5 -0.5 1.2 0.6 -0.6 -0.8 -0.0 -0.2 0.4
Ever taken oral contraceptive pill 0.6 0.7 3.3 0.6 0.1 1.8 -0.8 0.0 0.2 1.0 -0.6 0.1 -0.9
Hearing aid user 0.6 0.7 1.7 0.3 0.1 0.9 -0.8 -1.2 0.6 0.5 -1.3 -0.6 -1.0
Mother’s age at death 0.6 0.7 2.4 1.2 -0.3 0.8 0.3 -1.6 0.6 -0.8 0.5 0.4 1.1
Financial situation satisfaction 0.8 0.9 2.9 1.3 -0.2 0.3 0.7 1.1 -1.2 0.9 0.4 1.7 0.7
Tinnitus: Yes, now most or all of the time 0.6 0.8 4.1 0.8 0.1 -2.0 0.8 0.8 -0.7 0.1 -0.2 0.9 0.3
Commuting to job workplace: Public transport 0.5 0.6 2.9 0.3 -1.7 -0.7 0.0 -1.3 0.6 0.3 0.3 0.3 0.4
Eye problems/disorders: Glaucoma 1.6 1.9 7.5 -0.2 0.1 -0.6 1.9 -0.8 -1.9 -2.7 -0.7 -1.3 -0.9
Medication: Blood pressure 1.2 2.3 6.5 -0.6 -2.0 -2.1 -0.5 -1.6 0.5 1.4 -2.5 0.3 -1.7
Pain type(s) experienced in last month: Hip pain 0.9 1.2 4.4 -1.4 -1.1 0.9 1.4 -0.1 -0.1 -2.1 1.0 -0.5 0.3
Supplements: Fish oil (including cod liver oil) 1.3 1.7 9.3 -1.4 -3.0 -0.1 1.1 -1.5 0.1 0.3 0.6 -1.2 -0.2
High cholesterol (Self-reported) 3.4 6.0 17.6 -0.4 -3.2 0.0 1.1 -3.2 -0.1 -1.2 -4.2 -3.1 -3.0
Medication: Bendroflumethiazide 0.7 1.1 4.8 -1.1 -1.5 -2.2 0.8 -0.5 -0.6 -0.0 -0.8 -0.0 -0.9
Medication: Paracetamol 0.8 1.2 6.3 0.4 1.2 0.7 -0.6 2.5 0.0 1.5 1.1 0.3 -0.1
Medication: Lisinopril 0.5 0.6 2.2 -0.8 -0.6 -1.1 0.7 1.5 -0.1 0.1 -0.4 1.1 -0.0
Medication: Atorvastatin 0.6 0.7 2.8 0.7 -0.7 -1.4 -0.2 0.3 -0.3 0.3 -1.7 -0.3 -1.1
Illnesses of father: High blood pressure 0.2 0.3 1.6 0.4 -0.1 0.5 -0.4 -1.3 0.1 0.1 -0.1 0.5 0.1
Alcohol drinker status: Never 1.8 2.2 4.6 -1.8 -1.8 0.5 2.1 -0.7 -1.8 -1.4 0.6 -2.2 -0.6
Ever smoked 1.3 2.2 6.2 -1.1 2.3 -1.2 -1.8 1.4 0.7 2.5 -1.0 1.3 -0.1
Basal metabolic rate 0.6 3.5 13.4 -2.1 -0.2 -3.7 0.7 0.2 0.1 0.5 1.7 3.1 2.0
Leg fat percentage (left) 1.0 3.7 9.2 -2.5 -1.8 2.8 1.3 -3.0 -0.7 -1.3 -0.7 -1.2 -2.0
Arm fat-free mass (left) 0.8 4.1 13.8 -2.3 -0.9 -3.7 1.6 0.2 -0.9 1.0 1.9 3.0 2.0
Number of operations (self-reported) 4.0 5.9 14.7 0.6 2.3 -2.1 -3.4 0.5 3.3 2.7 0.1 3.8 2.1
Average weekly beer plus cider intake 0.9 1.3 4.4 -1.0 -0.3 0.1 1.2 -0.1 -0.5 -0.7 1.7 1.4 2.1
Irritability 1.1 1.9 6.9 0.3 1.7 -0.9 -2.6 -0.8 2.6 0.6 -0.6 -0.1 -0.6
Risk taking 1.1 1.6 3.5 1.5 -0.6 1.9 -1.2 -0.5 1.9 1.5 -0.2 0.8 1.2
Ever had prostate specific antigen (PSA) test 1.7 2.0 3.8 0.9 1.8 -1.3 -2.0 1.3 1.5 1.7 -0.3 1.7 0.8
Fractured/broken bones in last 5 years 0.5 0.7 2.8 -0.1 0.6 -0.7 1.3 -0.6 -1.0 -1.7 0.4 0.3 0.1
Age started oral contraceptive pill 1.0 1.3 2.4 1.2 -1.6 1.0 1.3 -1.4 -1.2 -0.9 1.2 -0.5 0.7
Diastolic blood pressure, automated reading 2.3 7.0 19.5 -2.2 -4.4 -0.1 0.4 -2.5 -0.2 1.9 -3.5 -2.6 -4.0
Ever depressed for a whole week 1.2 1.4 4.9 1.3 0.5 -2.2 -0.8 0.9 0.9 1.1 -0.8 1.8 0.5
Unable to work because of sickness or disability 0.5 0.7 2.2 1.5 0.0 1.1 -0.2 -0.6 1.3 -0.4 -0.4 0.8 0.5
Commuting to job workplace: Cycle 0.8 1.0 2.8 1.4 1.2 1.2 -0.1 1.7 -0.8 0.7 0.4 0.9 0.3
Myopia 1.7 2.5 13.1 1.7 3.6 1.2 -0.6 1.1 -0.6 -1.5 0.9 0.9 1.3
Vascular/heart problems diagnosed by doctor 1.5 4.2 19.0 -0.2 1.4 2.3 0.7 0.8 0.0 -2.2 4.4 0.7 3.1
Cholesterol lowering medication 1.2 1.8 7.4 1.1 -1.3 1.0 0.8 -1.4 -0.1 -1.0 -2.7 -1.0 -1.5
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.7 -0.2 -1.5 1.1 1.1 -1.6 0.1 -1.4 0.8 0.1 0.4
Pain experienced in last month 1.1 1.8 5.9 0.9 2.4 -1.2 -0.3 1.0 -0.2 -2.4 -1.8 -0.4 -0.7
Supplements: Calcium 0.6 0.7 2.3 1.3 -0.2 -1.5 -0.3 -1.0 1.1 -0.1 -0.6 0.4 0.2
Basal cell carcinoma (self-reported) 2.2 2.6 7.4 2.7 1.7 1.3 -2.5 -0.5 2.3 0.1 -1.1 0.9 -0.5
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.6 0.9 0.4 -1.9 -1.0 1.5 -0.2 1.8 -1.5 0.9 0.2
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 11.7 0.0 0.0 -1.3 -2.3 -0.0 3.4 1.1 -0.7 0.6 0.8
Heart disease (siblings) 0.8 0.9 3.5 -0.4 -0.5 -0.7 -1.3 -0.2 1.3 0.8 -1.9 -0.2 -0.8
Alcohol drinker status: Previous 1.1 1.2 3.6 1.1 -0.3 0.7 -1.6 -1.3 1.9 0.4 -1.1 -0.4 -1.0
Pack years of smoking 0.4 0.5 1.7 -1.1 -1.2 1.3 0.8 0.4 0.3 0.2 0.1 -0.0 0.1
Impedance of whole body 1.0 5.3 14.5 3.7 1.4 3.8 -1.1 -2.0 1.1 -2.5 -2.0 -2.1 -1.2
Leg fat mass (left) 0.4 1.7 7.2 -2.7 -1.5 1.0 1.1 -1.9 -0.3 -0.9 0.1 0.2 -0.8
Arm predicted mass (left) 0.8 4.1 12.5 -2.3 -0.8 -3.5 1.8 0.4 -1.0 0.7 2.1 3.1 2.0