Hub : Genes

PRPF6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.218	0.0680	6.1e-04	0.007	NA	0.005	NA	0.024	1.3e-01	NA	1.6e-01	NA	2.2e-02
2	GTEx	Breast Mammary Tissue (Male)	0.226	0.1087	4.3e-02	0.020	NA	0.133	NA	0.079	1.1e-01	NA	5.5e-04	NA	7.0e-03
3	GTEx	Breast Mammary Tissue (Female)	0.103	0.0873	1.7e-01	-0.010	NA	-0.009	NA	-0.010	1.0e+00	NA	7.8e-01	NA	8.9e-01
4	GTEx	Cells EBV-transformed lymphocytes	0.267	0.0890	5.0e-03	0.189	NA	0.042	NA	0.133	9.3e-07	NA	1.6e-02	NA	4.1e-05
5	GTEx	Esophagus Mucosa	0.156	0.0540	1.6e-03	-0.004	NA	-0.004	NA	-0.004	7.8e-01	NA	9.6e-01	NA	9.8e-01
6	GTEx	Muscle Skeletal	0.146	0.0421	3.3e-05	0.002	NA	0.002	NA	0.009	2.0e-01	NA	1.7e-01	NA	3.6e-02
7	ROSMAP	Brain Pre-frontal Cortex	0.154	0.0359	3.0e-07	0.054	0.072	0.117	0.1	0.113	1.8e-07	1.4e-09	7.5e-15	9.4e-13	2.6e-14
8	TCGA	Lung Squamous Cell Carcinoma	0.056	0.0340	4.2e-03	0.013	0.019	0.018	NA	0.011	1.1e-02	2.8e-03	3.7e-03	NA	1.6e-02
9	TCGA	Prostate Adenocarcinoma	0.106	0.0425	8.1e-04	0.009	0.038	0.036	NA	0.021	3.8e-02	7.7e-05	9.9e-05	NA	2.7e-03
10	TCGA	Thyroid Carcinoma	0.050	0.0260	4.1e-03	0.001	0.022	0.003	NA	0.008	2.8e-01	2.6e-03	1.4e-01	NA	4.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	2.0	3.2	9.2	1.6	2.8	1.1	-3.0	0.6	2.3	0.8	0.6	1.6	1.1
Bipolar Disorder or Schizophrenia	0.7	1.6	6.5	1.8	2.5	1.0	-1.4	-0.5	0.5	-1.5	-0.5	-0.7	-0.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.9	-1.0	-1.7	-1.1	-0.0	-1.2	0.9	0.2	-1.1	-0.3	-1.3
Depression (Nagel 2018)	0.7	1.1	2.8	-1.7	-0.9	-1.7	1.1	-0.9	-0.4	-1.4	-0.4	0.1	0.1
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.0	2.2	2.5	0.1	-2.6	1.0	2.0	1.9	-0.6	-0.6	-0.4
Neuroticism (Nagel 2018)	0.4	0.9	5.1	-0.8	-0.9	-2.3	-0.4	-0.7	0.7	0.3	-1.0	-0.2	-0.8
Schizophrenia (2018)	1.1	2.4	7.0	1.0	1.0	0.4	0.7	-1.0	-1.2	-2.6	-1.6	-2.4	-1.9
Schizophrenia vs Biploar Disorder	0.4	0.6	2.4	0.4	-0.6	-0.3	1.6	-0.4	-0.8	-1.4	0.0	0.0	0.0
Worry (Nagel 2018)	0.3	0.6	2.7	-0.0	-0.8	-1.6	0.4	0.2	-0.3	-0.6	-0.7	-1.1	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.6	-0.0	-0.9	1.2	0.2	-0.8	0.2	-0.3	0.4	0.1	0.7
Alzheimer’s Disease (in father)	0.7	0.7	2.0	-1.1	-1.4	-0.4	1.4	0.4	-0.7	0.0	0.6	0.8	0.8
Alzheimer’s Disease (including proxy)	0.2	0.4	0.9	-0.4	-0.8	0.8	0.5	-0.3	-0.2	-0.1	0.8	0.6	1.0
Crohns Disease (2017)	1.1	2.5	8.2	-1.5	-1.5	1.0	-1.3	-2.5	2.9	1.5	-0.6	-0.5	-0.6
Irritable Bowel Disease (IBD)	0.8	1.9	7.0	-2.0	-1.3	1.5	-0.9	-1.1	2.6	0.8	0.7	-0.6	0.2
Ulcerative Colitis (UC)	0.7	1.4	3.8	-1.4	-0.9	1.6	-0.2	1.0	1.5	0.7	1.9	-0.3	1.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.4	1.7	0.1	0.1	0.7	-0.0	0.3	-0.5	-1.1	-0.6	1.3	-0.0
Verbal and Numeric Reasoning (VNR)	1.3	3.2	9.0	2.6	1.2	0.2	-2.7	-0.5	3.0	1.5	-1.9	-0.3	-1.0
Breast Cancer	1.4	3.4	10.2	-1.1	-3.2	-2.6	0.7	0.1	0.8	0.7	-2.6	-1.7	-2.2
Ovarian Cancer	1.3	1.8	6.2	-2.0	-1.2	0.8	-0.2	-0.4	0.6	0.7	-0.3	-2.1	-2.5
Prostate Cancer	0.9	1.2	3.6	0.7	-0.3	-1.9	-0.7	-1.1	0.9	1.8	0.1	1.4	0.6
Age at First Birth	0.5	0.7	2.8	1.7	1.1	0.3	0.3	0.3	-0.3	-1.2	0.2	1.0	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-1.3	-0.9	1.0	1.3	0.4	-0.8	-0.9	0.9	-0.4	-0.1
Coronary Artery Disease (CAD)	1.0	1.2	5.6	-1.8	-2.4	-1.3	0.7	-0.7	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.4	2.3	9.3	-1.1	-0.4	0.3	-1.8	-2.5	3.0	1.2	0.4	0.5	0.7
Mean Putamen Volume	0.8	1.0	3.2	0.7	1.8	1.1	0.6	-0.0	-1.2	-1.5	-0.5	0.4	0.5
Fasting Glucose	0.9	1.0	3.5	0.6	1.4	-1.9	-0.9	1.2	-0.4	0.9	-1.0	0.1	-0.5
HbA1C	1.3	1.4	4.2	0.3	-1.2	0.2	-0.9	-0.5	0.8	1.0	-2.1	-1.4	-1.9
HDL Cholesterol	0.8	1.4	3.7	0.6	1.8	-0.7	0.3	1.9	-1.2	0.7	1.7	0.1	1.0
LDL Cholesterol	0.6	0.9	2.3	1.5	0.3	-0.8	0.6	0.4	-0.9	-1.5	-1.5	0.0	-0.9
Lupus	0.5	0.8	3.5	-0.4	1.9	-1.0	-0.5	1.2	-0.2	0.2	-0.3	1.0	0.3
Neuroticism (2016)	2.1	3.0	7.9	-1.3	0.2	-2.8	-1.1	0.8	0.4	0.8	-2.4	-2.2	-2.7
Primary Biliary Cirrhosis	0.4	0.6	2.4	-0.5	-0.7	0.3	0.2	0.1	0.1	0.3	0.4	1.5	1.5
Rheumatoid Arthritis	2.6	3.6	14.6	-0.3	-0.6	1.9	1.3	1.5	-1.8	0.2	3.8	1.2	2.9
Schizophrenia (2014)	0.5	1.2	2.8	1.0	1.6	0.4	-0.4	-0.1	-0.1	-1.7	-0.9	-1.7	-1.2
Triglycerides	0.7	1.2	2.9	1.4	-1.3	1.7	0.3	-1.4	0.4	-0.3	-1.2	-0.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	4.0	-0.7	-1.0	0.5	-0.1	-2.0	0.0	0.1	0.0	0.0	0.0
Ulcerative Colitis	0.5	0.7	3.1	-1.8	-0.8	0.2	-0.2	-0.7	1.1	-0.8	-0.0	-0.9	-0.2
Blood Eosinophil Count	0.5	3.9	15.0	1.4	1.2	1.9	-0.7	-3.9	1.9	-1.9	-0.1	1.9	2.4
Blood Platelet Count	0.3	3.2	21.8	-0.0	-2.3	-1.6	-0.1	-4.7	1.2	-0.6	-0.7	0.0	0.6
Blood Red Count	0.2	2.2	5.6	1.6	2.0	2.4	-0.4	-0.0	-1.2	-1.1	-1.6	-0.5	-2.1
Blood White Count	0.8	6.1	20.2	2.1	-1.2	1.2	-1.4	-2.3	1.4	1.8	1.6	4.5	4.3
Heel T-Score	0.7	5.6	20.3	1.5	1.5	-0.2	-3.6	3.3	1.4	4.5	-1.6	1.6	-0.0
BMI	0.3	1.9	8.9	-3.0	-2.0	0.5	1.1	-1.3	-0.9	0.5	1.3	0.7	-0.3
Height	0.3	5.2	21.4	1.2	1.8	-4.6	-1.9	-1.8	3.3	-0.7	-2.0	1.6	0.6
Waist Hip Ratio (WHR)	1.2	5.2	15.6	1.9	-0.5	1.7	0.4	-3.9	0.2	-1.8	-3.5	-2.3	-2.9
Systolic Blood Pressure	0.7	3.8	17.8	-0.1	-2.1	-2.6	0.3	-0.6	-0.5	1.4	-4.2	0.6	-2.3
Smoking Status	0.9	2.3	5.1	-1.9	0.3	-1.8	-2.0	0.1	2.0	2.3	-1.2	0.2	-0.9
Allergy or Eczema	1.1	2.9	7.6	2.0	1.3	-1.1	-1.9	-1.2	2.8	-0.1	-0.9	2.2	1.9
Cardiovascular Disease	1.8	5.9	21.8	-0.3	-3.4	-1.7	-0.2	-3.2	0.2	2.0	-4.7	-0.4	-2.8
Hypothyroidism (self reported)	1.9	4.4	14.2	0.4	0.7	-1.8	-1.6	-1.3	1.2	-0.6	-3.8	-3.0	-3.3
Respiratory disease	1.4	3.0	14.5	0.5	-2.0	0.5	-1.2	-3.8	2.7	1.4	-0.5	0.3	-0.3
Type 2 Diabetes (T2D) (2018)	1.6	3.0	10.6	0.4	1.1	-0.6	-2.0	-2.5	2.5	0.2	-3.2	0.5	-0.9
Lung FEV1/FVC ratio	0.7	3.6	10.0	-2.6	-2.2	-0.2	2.8	1.5	-3.2	0.3	1.7	-0.6	0.2
Lung FVC	1.4	7.1	48.9	-0.9	2.8	-1.6	-0.4	7.0	-1.9	1.2	0.4	-2.1	-1.2
Neuroticism	0.6	1.5	9.4	-1.4	0.1	-3.1	-0.5	-0.2	0.2	-0.3	-1.3	-0.3	-1.3
Chronotype (morning person)	0.4	0.9	2.2	-0.8	1.5	-1.5	-0.2	0.1	-0.4	-0.8	-1.0	-1.0	-0.8
Hair Pigment	0.1	3.0	8.8	-3.0	-1.5	1.4	2.3	-1.4	-1.8	-0.7	2.2	-0.4	0.9
Tanning	0.1	0.9	3.0	0.5	-0.9	-1.7	1.2	1.0	-1.3	0.1	0.7	0.3	0.2
Hand grip strength (left)	1.0	2.7	10.8	-2.0	-0.6	-3.3	2.1	0.7	-2.4	1.1	0.2	0.6	-0.1
Number of treatments/medications taken	0.6	1.1	2.8	-0.8	-0.1	-0.0	-1.4	-0.5	1.6	1.2	-1.7	-0.1	-1.1
Average weekly spirits intake	0.3	0.4	0.9	-0.7	0.2	0.8	1.0	-0.1	-1.0	-0.3	0.4	0.8	0.7
Sensitivity / hurt feelings	0.5	0.8	2.8	-0.4	1.6	-1.7	-0.6	0.5	0.2	-0.3	-0.9	1.0	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-0.5	-0.7	-0.7	1.1	0.5	0.2	-1.0	0.3	1.3	1.2
Hearing difficulty/problems: Yes	0.3	0.5	2.2	-0.4	-0.4	-1.2	-0.2	-0.6	-0.2	1.5	0.4	0.4	0.6
Relative age of first facial hair	0.5	1.1	4.8	1.3	-2.2	0.3	0.7	-0.2	-0.2	0.1	-0.6	-1.4	-1.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.7	0.4	1.6	-2.2	-0.3	1.4	0.6	1.0	-0.3	1.8	1.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	0.2	0.4	1.0	-0.1	-0.1	-0.1	0.5	0.2	1.1	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	2.6	-0.4	0.6	-0.4	0.0	-0.4	-0.5	1.6	-0.1	0.1	-0.5
Systolic blood pressure, automated reading	1.6	4.5	21.5	-0.4	-1.7	-1.1	0.4	-2.3	-0.3	0.6	-4.6	-1.3	-3.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.4	1.3	-0.2	0.1	0.1	-0.1	0.4	0.0	0.0	1.5	1.1
Angina	1.7	2.2	10.8	-0.1	0.2	-2.4	-0.8	-0.1	0.2	0.3	-3.3	-0.5	-2.2
Medication for hormone replacement therapy	1.1	1.2	4.2	1.1	1.3	-1.1	-0.8	2.0	0.4	1.7	-0.5	0.1	0.1
Vitamin and mineral supplements	1.5	2.0	4.8	-1.3	0.9	1.1	-1.7	-1.5	1.4	-0.4	-2.2	-1.2	-1.7
Supplements: Zinc	1.2	1.3	7.1	1.4	-0.0	0.2	-1.1	-0.0	0.7	2.7	-0.9	-0.5	-0.8
Medication: Co-codamol	0.5	0.5	1.1	0.5	0.9	0.9	-0.5	0.7	0.4	0.7	-1.0	-0.2	-1.0
Medication: Metformin	2.2	3.1	10.1	-0.2	-0.1	-0.1	-2.4	-2.9	3.2	1.6	-2.0	0.3	-0.6
Diabetes (father)	0.3	0.4	1.7	-0.4	-0.0	1.0	0.4	-1.3	-0.1	-0.9	0.4	0.2	0.0
Diabetes (mother)	3.3	4.2	12.6	-1.8	-0.9	-1.1	-1.1	-1.9	1.0	-1.4	-3.3	-2.4	-3.5
Severe depression (siblings)	0.6	0.6	4.5	0.6	-0.3	0.5	-0.1	-2.1	0.7	0.2	-0.2	0.7	0.3
Pack years adult smoking proportion	0.4	0.6	1.6	-1.1	-1.3	0.7	1.1	0.6	0.0	0.2	0.7	0.4	0.6
Impedance of leg (right)	0.8	3.8	10.2	1.6	0.3	3.2	-0.6	-1.9	0.4	-0.2	-2.4	-2.7	-2.8
Leg fat-free mass (left)	0.6	3.3	10.9	-1.7	0.4	-3.2	0.2	0.5	0.7	-0.1	1.6	3.3	2.3
Trunk fat percentage	0.7	2.9	8.5	-1.4	-1.0	2.8	0.1	-2.9	1.0	-2.0	-1.2	-1.1	-1.4
Hand grip strength (right)	0.7	1.9	6.8	-0.9	-0.7	-2.6	1.8	0.8	-2.1	1.2	0.4	0.8	-0.1
Townsend deprivation index at recruitment	1.6	2.3	6.2	0.8	0.5	1.7	-2.5	-0.9	2.2	2.1	-0.5	1.5	0.1
Current tobacco smoking	1.4	2.3	11.3	-3.4	-0.7	-1.0	-1.0	0.5	1.6	1.7	-1.1	-0.7	-1.4
Average weekly fortified wine intake	0.6	0.7	2.1	-1.5	-1.0	-0.2	1.2	-0.7	-1.1	-0.2	-0.1	-0.4	-0.5
Maternal smoking around birth	1.0	1.4	5.2	-1.2	-2.3	-0.2	1.8	-1.6	-0.6	-0.7	-0.1	-0.5	-0.3
Fed-up feelings	0.4	0.7	2.7	-0.8	-1.1	0.1	-0.6	-0.5	1.0	1.6	-0.4	0.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.2	-0.5	0.2	-1.5	-0.1	0.2	0.3	-0.6	-0.6	0.6	-0.1
Relative age voice broke	2.0	3.0	9.4	0.4	-2.2	-0.2	0.3	-0.9	-0.1	0.8	-2.3	-3.0	-3.1
Taking other prescription medications	1.6	2.5	6.4	-1.5	0.5	-1.0	-1.7	-1.8	2.2	-0.4	-2.5	-1.0	-1.7
Age when periods started (menarche)	0.9	2.2	8.5	2.9	-0.3	2.5	0.7	0.3	-1.2	0.7	1.7	0.6	1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.9	-1.5	-0.1	-2.2	0.1	-0.4	-0.1	1.4	-0.7	-0.2	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	6.5	0.6	-0.9	-0.4	-1.2	-0.6	0.7	2.5	-0.9	-0.0	-0.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	5.2	-0.3	-0.4	-0.4	2.3	0.5	-2.0	-1.6	2.0	0.2	1.2
Qualifications: CSEs or equivalent	1.4	1.8	8.2	-0.9	-2.9	-1.3	0.5	-1.8	0.2	1.7	0.9	0.6	0.2
Serious illness, injury or assault to yourself	0.9	1.1	4.1	1.2	2.0	-0.2	-0.6	1.2	0.0	-0.3	-0.1	1.9	0.6
High blood pressure	1.2	3.3	11.5	0.1	-1.8	-2.0	-0.5	-0.9	-0.3	2.6	-3.4	-0.1	-2.5
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.9	1.6	1.4	-1.0	-2.3	-0.3	2.8	-0.0	-0.5	2.0	1.7
Multivitamins +/- minerals	1.5	1.9	4.4	1.5	-1.5	-1.2	1.7	1.3	-1.0	0.2	2.1	1.1	1.1
Stomach or abdominal pain in last month	1.2	1.4	3.7	1.9	0.1	-0.7	-1.0	1.0	1.1	1.8	0.8	1.4	1.1
Supplements: Glucosamine	0.5	0.7	2.8	-0.5	-1.7	0.3	0.8	-1.1	-0.3	0.2	0.9	0.9	0.6
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.6	1.9	-0.1	0.5	1.2	1.8	-1.0	-0.6	2.0	2.2	1.9
Medication: Atenolol	0.7	0.8	3.1	-1.2	-0.5	-1.8	0.4	-0.1	-0.8	-0.4	-1.4	0.5	-0.6
Medication: Levothyroxine sodium	4.0	6.7	17.7	-1.5	-0.4	-2.5	-2.4	-1.0	2.5	0.6	-4.2	-3.4	-4.0
Sitting height	0.6	4.0	13.2	1.2	1.9	-3.6	-1.2	1.8	1.2	0.9	0.9	3.1	2.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.6	-0.6	0.4	0.6	-0.1	-1.6	0.2	-0.8	-0.6	-0.6	-0.9
High blood pressure (mother)	0.4	0.5	1.0	1.0	0.5	-0.4	-1.0	-0.8	0.3	0.9	-0.2	0.9	-0.4
Body mass index (BMI)	0.4	1.6	9.4	-3.1	-1.6	0.7	1.2	-1.0	-0.6	-0.3	0.4	0.0	-0.7
Impedance of leg (left)	0.7	3.5	10.1	2.2	-0.2	3.2	-0.0	-2.3	-0.2	-0.9	-1.8	-2.5	-2.0
Leg predicted mass (left)	0.6	3.3	11.2	-1.6	0.4	-3.1	0.3	0.4	0.6	-0.2	1.7	3.4	2.4
Trunk fat mass	0.4	1.7	6.3	-2.0	-1.0	1.2	0.4	-2.5	0.8	-1.7	-0.6	-0.2	-0.8
Waist circumference	0.5	1.7	7.5	-2.1	-1.3	0.6	0.9	-2.7	0.2	-1.0	-0.8	0.2	-1.0
Number of incorrect matches in round	0.5	0.8	2.4	-0.3	-0.4	-0.6	0.9	1.3	-1.5	0.2	1.2	-0.7	0.3
Past tobacco smoking	1.2	2.2	7.6	0.2	-2.8	1.3	1.5	-1.4	-0.2	-2.2	0.6	-1.7	-0.5
Alcohol usually taken with meals	0.2	0.4	1.0	0.7	-0.9	0.3	-0.4	0.8	-0.1	1.0	-0.1	0.8	0.3
Nervous feelings	0.3	0.5	1.3	0.8	0.5	-0.8	-0.1	0.4	-0.5	-0.5	-0.7	-1.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	6.5	-2.1	-2.5	0.0	-0.1	-1.4	0.8	0.1	-0.5	-1.1	-0.8
Hearing difficulty/problems with background noise	0.2	0.4	2.4	0.2	-0.5	-1.5	-0.5	-0.5	0.4	0.0	-0.2	-0.5	-0.4
Hair/balding pattern: Pattern 2	1.0	1.3	2.7	-1.2	0.5	-1.6	-1.7	-1.3	1.6	-0.0	-0.9	-0.3	-0.9
Had menopause	0.8	1.0	3.7	-0.1	-0.3	0.1	1.5	-0.2	-0.9	-1.9	-0.4	-1.7	-0.2
Had other major operations	1.8	2.2	3.6	-0.9	1.6	-1.0	-1.9	1.0	1.7	1.9	1.4	1.4	1.5
Forced vital capacity (FVC)	1.4	5.4	29.3	1.3	3.5	-2.1	-1.1	5.4	-0.9	1.6	0.7	0.7	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	4.2	0.4	-1.0	-0.8	-0.7	0.0	0.6	2.0	-0.5	-0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.2	-0.3	0.7	-1.3	-0.6	0.0	0.6	0.3	0.0	1.8	0.7
Qualifications: None of the above	0.6	1.4	4.7	-1.5	-0.7	2.2	1.4	0.3	-1.4	-1.3	0.4	-0.3	-0.2
Financial difficulties in last 2 years	0.2	0.3	1.1	-0.6	0.2	0.9	0.3	-0.7	0.3	-0.5	0.1	1.0	0.4
Mouth/teeth dental problems	0.6	1.0	3.9	1.0	0.9	-1.1	0.5	2.0	-0.6	0.1	-0.1	1.2	0.8
Heart attack	1.1	1.4	4.7	0.6	0.2	-2.2	-0.8	1.5	-0.3	1.8	-1.4	0.9	0.2
Allergy	1.5	3.5	15.6	-1.4	-0.4	1.0	2.8	1.4	-4.0	-0.3	0.7	-1.9	-1.6
Pain all over the body in last month	1.0	1.1	3.7	-1.3	-1.9	0.6	0.9	-1.2	0.2	0.2	-0.7	-0.8	-1.3
Diabetes (self-reported)	1.5	2.3	6.2	1.1	1.7	0.3	-2.0	-1.4	2.5	0.4	-2.4	0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.4	-0.8	-1.6	-0.0	1.0	-1.2	0.3	-1.4	-0.1	-0.4	0.1
Medication: Ramipril	1.5	1.9	7.5	0.2	-1.6	-0.8	-0.9	-1.3	1.4	0.1	-2.7	-1.1	-1.7
Medication: Simvastatin	1.9	2.8	13.3	0.5	-1.7	1.2	-0.2	-1.5	0.9	-0.0	-3.6	-1.8	-2.0
Fluid intelligence score	0.8	1.6	7.1	2.7	0.4	0.3	-1.4	0.4	1.6	0.4	-1.4	-1.1	-0.9
Illnesses of siblings	2.4	3.4	9.6	-0.7	0.4	-0.2	2.2	1.9	-1.4	-2.1	2.7	1.1	3.1
Neuroticism score	0.2	0.5	2.4	-0.5	0.3	-1.6	-0.6	-0.2	0.6	-0.3	-0.8	0.2	-0.7
Weight	0.3	1.4	5.3	-2.3	-0.6	-1.3	0.9	-1.0	0.1	-0.8	0.7	1.7	0.8
Impedance of arm (right)	1.1	5.2	12.5	3.5	2.1	3.3	-2.1	-1.9	2.3	-2.5	-1.7	-0.9	-0.4
Arm fat percentage (right)	0.6	2.3	6.3	-1.8	-1.0	2.5	0.2	-2.5	0.8	-1.5	-0.9	-0.8	-1.5
Trunk fat-free mass	0.9	5.0	23.8	-2.1	-0.2	-4.9	0.6	0.8	-0.1	1.5	1.8	3.3	2.1
Hip circumference	0.3	1.2	8.0	-2.8	-0.9	-0.5	0.3	-1.0	0.5	-0.1	0.7	0.9	0.2
Time employed in main current job	0.6	0.7	1.8	-0.9	-0.6	-0.8	0.9	-0.1	-0.8	-1.3	1.1	0.3	0.6
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-0.6	-0.8	0.8	0.5	-0.5	-0.9	-0.6	0.9	0.5	0.3
Father’s age at death	0.7	1.0	4.1	-0.6	-1.1	0.3	0.4	-1.3	0.4	-0.9	-0.7	-2.0	-0.9
Worrier / anxious feelings	0.2	0.3	1.0	0.4	1.0	-0.7	-0.2	0.8	-0.2	-0.7	-0.6	0.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.5	-0.5	0.4	0.6	-1.2	-0.1	1.4	0.7	-0.9	1.9	-0.0
Falls in the last year	0.7	1.0	4.6	-0.4	-0.3	0.9	-0.9	-2.2	1.0	0.4	-1.3	0.1	-0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-0.7	0.3	-0.3	-1.2	0.5	1.0	0.4	0.1	-0.5	-0.4
Number of live births	1.6	2.3	7.0	-0.1	-1.7	0.2	1.2	-2.7	-0.5	-0.9	-1.7	-2.2	-1.7
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	22.3	0.5	2.2	-2.1	-0.0	4.7	-1.7	1.2	1.6	1.0	0.9
Pulse rate	1.9	3.3	14.6	0.5	-1.4	3.8	0.8	-0.4	-1.1	0.3	-0.5	-3.0	-2.2
Happiness	0.7	0.9	2.0	-0.1	-0.9	0.5	0.7	1.4	-0.7	1.4	1.1	0.8	0.8
Noisy workplace	0.3	0.4	1.7	0.2	0.2	0.6	0.5	0.1	-0.3	-0.4	0.9	1.3	0.8
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.1	0.7	-0.4	-2.0	-1.6	-1.4	1.2	1.8	-0.7	-0.6	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.2	1.0	1.6	-0.3	-0.6	1.3	-0.1	0.4	1.5	2.3	1.9
Mouth/teeth dental problems: Dentures	1.3	2.2	4.4	-2.1	-1.6	1.7	-0.8	-1.2	1.0	1.6	-0.6	-1.8	-1.6
Asthma	1.6	3.1	14.2	0.4	-1.9	-0.2	-1.5	-3.8	2.8	0.8	-0.9	-1.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.9	-0.1	0.4	0.8	0.1	0.4	-0.4	-0.1	0.5	1.4	-0.1
Medication: Cholesterol lowering	1.7	2.7	15.2	0.3	-1.1	-1.8	-0.6	-1.1	0.8	0.1	-3.9	-1.2	-1.8
Depression (self-reported)	0.8	0.9	2.4	1.5	1.4	-1.2	-0.1	0.7	-0.0	-1.1	-1.1	-0.1	-0.5
Medication: Lansoprazole	2.6	2.9	9.3	0.1	0.7	1.0	-2.8	-0.7	3.0	1.7	-2.0	-0.3	-1.8
Prospective memory result	2.3	2.8	6.3	-1.3	-2.2	2.4	2.5	-0.1	-1.6	-1.8	1.7	-0.9	0.0
Lung cancer (father)	0.5	0.6	3.0	0.3	-0.1	-0.6	0.1	0.7	-0.9	1.7	0.5	-0.8	-0.3
Illnesses of mother	1.5	1.9	5.7	1.1	-0.0	0.7	0.6	1.8	-0.8	0.5	2.4	1.6	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	12.1	0.2	1.8	-3.0	-0.7	3.5	-1.0	1.3	1.2	1.3	0.8
Pulse wave Arterial Stiffness index	1.0	1.2	2.0	1.3	-0.2	0.7	-1.3	-1.0	1.1	1.2	-1.3	-0.3	-1.4
Impedance of arm (left)	1.3	6.2	15.2	3.9	2.9	3.2	-2.4	-1.5	2.4	-2.8	-2.1	-1.2	-0.6
Arm fat mass (right)	0.3	1.2	4.9	-2.2	-0.9	0.7	0.7	-1.8	0.2	-1.1	0.0	0.5	-0.4
Trunk predicted mass	0.9	5.0	23.8	-2.0	-0.1	-4.9	0.6	0.8	-0.1	1.4	1.8	3.4	2.1
Standing height	0.6	5.6	21.8	1.4	1.5	-4.7	-0.4	-0.3	1.4	-1.0	1.1	3.8	3.3
Length of working week for main job	2.5	2.7	10.0	-0.2	-1.6	-0.1	1.6	0.7	-0.8	-1.1	3.2	1.8	2.6
Exposure to tobacco smoke at home	0.4	0.5	2.0	-0.9	-0.2	1.4	0.7	0.0	-0.6	0.2	0.9	-0.3	0.3
Breastfed as a baby	0.7	0.9	3.8	0.0	-0.0	-0.4	-1.0	-1.9	0.9	0.6	-1.1	-0.9	-0.6
Tense / ‘highly strung’	0.2	0.3	0.9	-0.1	-0.6	-1.0	0.0	-0.4	0.2	0.0	0.4	0.9	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.5	0.6	1.1	-2.1	-0.2	2.1	0.0	0.9	-0.3	2.1	0.5
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	0.7	0.7	1.1	-0.1	1.3	-0.6	1.1	0.1	0.3	0.0
Birth weight of first child	0.8	1.5	3.3	-1.4	1.8	-0.2	-1.4	0.7	1.7	0.3	1.5	0.9	1.3
Peak expiratory flow (PEF)	0.6	1.4	3.7	-0.6	1.1	-1.9	-0.4	1.9	-0.3	1.2	0.9	1.1	1.1
Pulse wave reflection index	0.5	0.6	1.6	1.3	-0.4	-1.1	-0.6	-0.6	0.6	0.8	0.1	0.9	0.1
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.9	0.1	0.8	0.5	0.8	0.6	-1.2	0.9	1.4	1.7	0.6
Loud music exposure frequency	2.3	2.5	8.5	-1.1	-1.0	0.1	0.9	0.8	-0.6	0.1	2.9	2.4	2.5
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.7	2.0	1.3	-1.8	-2.4	0.5	1.5	2.3	-0.2	1.8	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	0.3	0.0	-0.7	0.6	-1.1	-0.8	-0.6	1.1	-0.1	0.7
Blood clot in the leg (DVT)	1.4	1.7	9.1	-0.2	0.2	-1.5	-2.0	0.2	3.0	0.8	-0.8	0.5	0.7
Medication: Paracetamol	0.8	1.3	6.0	0.8	0.7	0.4	-0.2	2.5	-0.4	1.6	1.3	0.9	0.1
Headache pain in last month	1.2	2.1	6.6	2.6	-0.8	1.5	-0.9	0.1	0.9	2.0	1.3	1.8	1.2
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	14.4	0.7	1.7	1.8	-0.0	0.9	-0.1	-0.4	3.8	1.7	2.6
Glaucoma (self-reported)	0.8	0.9	3.7	-1.0	1.0	-0.8	0.7	-0.6	-1.2	-1.9	-0.4	-0.1	-0.0
Gout (self-reported)	1.4	2.0	6.0	-0.6	0.1	-2.2	-0.1	0.4	-0.2	-0.7	-2.4	-2.0	-2.0
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	12.9	-0.7	-0.1	-1.4	-1.6	-1.0	1.6	0.4	-3.5	-3.6	-3.6
Medication: Amlodipine	0.9	1.2	3.5	1.2	0.1	0.0	-1.2	1.9	0.5	1.6	-1.1	0.3	-1.2
Medication: Ventolin 100micrograms inhaler	1.5	2.0	11.4	-0.4	-1.7	-0.6	0.9	-3.4	0.6	-1.6	0.1	-1.1	-0.2
Birth weight	1.2	2.7	14.7	-1.7	3.8	-1.1	-0.4	1.8	0.2	-2.0	-0.0	-0.3	0.6
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.8	0.4	0.2	0.1	-0.1	-2.2	0.9	-1.8	-0.8	-0.2	-0.9
High blood pressure (siblings)	1.0	1.5	5.6	0.6	0.2	-0.7	-1.0	-0.7	0.3	1.6	-1.8	-1.0	-2.4
Forced vital capacity (FVC), Best measure	1.0	3.8	14.3	0.8	2.6	-3.3	-1.2	3.8	-0.6	1.2	0.7	1.0	0.4
Body fat percentage	0.8	3.1	8.5	-2.0	-1.2	2.9	0.4	-2.9	0.5	-1.8	-1.2	-1.2	-1.7
Leg fat percentage (right)	1.0	3.7	7.7	-2.8	-1.5	2.7	0.8	-2.6	-0.3	-0.9	-1.2	-1.5	-2.7
Arm fat-free mass (right)	0.7	3.6	15.1	-2.3	-0.6	-3.9	1.3	0.8	-0.7	1.1	1.6	2.5	1.6
Exposure to tobacco smoke outside home	1.7	2.3	13.0	1.0	-0.9	3.6	1.7	0.2	-1.0	-1.1	0.8	-1.1	-0.8
Comparative body size at age 10	0.9	2.5	6.1	-2.5	0.4	-0.4	2.3	1.2	-2.3	-2.5	0.5	0.2	0.7
Number of full brothers	0.7	0.9	1.5	0.3	0.7	0.8	-1.2	-1.2	1.2	1.1	-0.8	-0.8	-0.8
Worry too long after embarrassment	1.0	1.6	9.7	-2.2	0.8	-3.1	-0.5	0.7	0.1	-0.0	-0.6	0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.6	1.7	1.9	-0.5	1.5	1.1	-1.2	-1.7	1.1	1.9	1.7
Wheeze or whistling in the chest in last year	1.5	2.7	6.8	-1.7	-2.6	0.4	-1.1	-2.4	2.4	2.0	0.1	0.3	-0.2
Number of children fathered	0.3	0.3	1.0	-1.0	-0.6	-1.0	0.5	-0.0	-0.4	0.2	-0.2	-0.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.3	-0.1	-0.7	-0.1	0.6	0.1	-0.6	0.0	-0.4	0.1
Age at first live birth	1.4	2.4	4.7	2.2	0.7	-0.0	1.5	1.7	-1.1	-1.8	1.9	1.4	2.0
Pulse wave peak to peak time	1.1	1.3	2.5	-1.4	0.2	-1.1	1.4	0.9	-1.2	-1.2	1.3	0.5	1.6
Health satisfaction	0.6	0.8	3.4	-0.0	1.8	0.8	0.5	1.5	-0.9	0.1	-0.2	0.4	0.1
Shortness of breath walking on level ground	2.4	2.8	6.5	0.4	0.2	0.8	2.0	0.3	-1.6	-1.6	2.6	2.4	2.5
Qualifications: College or University degree	0.4	1.1	4.1	2.0	0.7	-0.5	-1.7	0.7	1.7	0.2	0.1	-0.3	0.3
Eye problems/disorders: None of the above	0.2	0.3	1.9	-0.2	0.1	0.5	-0.0	-0.2	-1.4	0.4	0.3	0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.8	-1.9	-0.2	-1.8	-0.4	-1.2	1.1	-0.7	-0.8	0.0	0.3
Emphysema/chronic bronchitis	1.1	1.2	4.5	-0.2	-1.3	2.1	1.2	-0.2	-0.8	-0.3	1.4	0.9	1.2
Medication for pain relief, constipation, heartburn	0.6	1.0	3.5	1.0	1.0	-0.2	0.3	-0.3	-0.6	-1.9	1.3	-0.0	1.5
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	0.3	-0.9	-1.1	0.3	1.1	1.0	0.2	0.5	-0.2
Medication: Blood pressure	1.2	2.0	5.9	-0.9	-1.3	-1.8	-0.7	0.8	0.2	1.8	-2.4	-0.6	-2.0
Angina (self-reported)	1.7	2.3	11.0	-0.2	-0.0	-2.4	-0.7	-0.3	0.1	0.5	-3.3	-0.6	-2.2
Migraine (self-reported)	0.2	0.2	1.0	-0.3	-0.1	-0.5	-0.1	-0.3	-0.5	-0.4	-0.6	1.0	-0.4
Medication: Ibuprofen	0.3	0.3	0.9	-0.9	0.5	1.0	0.1	0.3	-0.5	-0.5	-0.0	0.1	-0.9
Medication: Allopurinol	1.8	2.4	5.7	-1.2	1.4	-2.4	0.0	2.3	-0.9	-0.3	-1.9	-1.7	-1.3
Medication: Omeprazole	1.2	1.4	3.6	0.5	0.1	0.7	1.1	-0.3	-0.5	-1.5	1.7	1.7	1.9
Medication: Seretide 50 evohaler	0.2	0.3	1.5	-1.2	0.0	-0.6	-0.1	0.0	-0.0	-0.3	0.7	-0.3	0.2
Mean time to correctly identify matches	0.1	0.3	0.7	-0.3	-0.0	0.6	0.3	0.1	-0.8	-0.8	-0.7	0.6	-0.3
Heart disease (mother)	2.3	2.8	7.1	-0.5	-2.2	-0.6	0.6	-2.7	0.6	-1.1	-1.9	-2.3	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	5.6	-0.2	0.6	0.5	0.3	0.5	0.1	-0.4	1.1	2.4	1.5
Whole body fat mass	0.4	1.8	5.8	-2.4	-1.5	1.0	0.8	-2.4	0.4	-1.2	-0.3	-0.1	-0.8
Leg fat mass (right)	0.4	1.6	8.0	-2.8	-1.4	0.9	1.0	-1.7	-0.1	-0.7	-0.2	-0.0	-1.1
Arm predicted mass (right)	0.8	4.1	15.7	-2.3	-0.7	-4.0	1.7	0.7	-1.0	0.7	1.8	2.7	1.9
Pulse rate, automated reading	1.2	3.8	26.5	0.4	-0.7	5.2	1.2	-0.8	-1.0	-0.5	0.1	-2.5	-1.2
Alcohol intake frequency.	0.5	1.2	3.8	1.8	0.1	2.0	-0.1	0.2	-0.3	-1.4	1.1	1.0	0.7
Comparative height size at age 10	0.6	3.1	22.2	-1.1	0.8	-4.7	0.6	-0.8	0.6	-1.7	-0.7	1.3	0.8
Number of full sisters	1.8	2.2	5.2	-0.1	0.4	0.3	-2.1	-0.6	1.6	2.3	-2.1	-1.0	-2.0
Suffer from ‘nerves’	0.3	0.4	2.0	-0.4	0.3	-0.5	0.5	0.2	-0.4	-1.4	0.7	0.6	0.7
Overall health rating	0.8	1.6	3.6	-1.0	-0.7	1.6	-1.1	-1.2	1.8	0.6	-1.9	-0.4	-1.5
Chest pain or discomfort	1.4	2.0	5.8	-0.6	0.4	-0.5	-2.2	-1.4	2.4	1.6	-1.6	1.2	-0.4
Had major operations	2.2	2.6	4.5	1.6	1.6	-1.3	-2.0	1.8	2.1	1.2	-0.4	2.1	1.1
Age at last live birth	1.2	1.8	4.9	2.1	0.2	-0.3	0.5	1.0	-0.6	-0.8	1.6	1.9	2.2
Family relationship satisfaction	0.5	0.7	3.6	1.2	0.2	-0.4	-0.0	0.6	-0.1	0.7	-0.1	1.9	0.8
Leg pain on walking	1.2	1.6	6.4	0.6	0.4	0.2	0.8	0.8	-0.4	0.7	1.5	2.5	2.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.4	0.6	0.2	-1.3	-1.2	-1.0	1.0	2.1	-1.7	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.1	0.1	0.4	0.8	-0.0	-0.4	-1.2	0.9	0.8	0.6
Illness, injury, bereavement, stress in last 2 years	2.8	3.5	13.4	-1.4	-2.9	0.4	0.9	-0.7	-0.6	0.8	-0.7	-3.7	-2.8
Medication: Aspirin	1.3	1.7	8.8	1.4	-0.2	-0.3	-1.1	-0.3	1.2	1.7	-3.0	0.2	-0.9
Supplements: Vitamin C	0.7	0.8	3.2	0.9	-1.2	-1.1	0.8	-0.1	-0.7	1.8	-0.1	-0.2	0.3
Knee pain experienced in last month	0.5	0.7	2.4	-0.9	-0.1	0.3	-0.4	-0.6	0.8	1.2	0.7	1.6	0.9
Hypertension (Self-reported)	1.1	2.9	9.9	-0.2	-1.9	-2.1	-0.2	-0.9	-0.6	2.1	-3.1	-0.2	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.5	0.1	-1.9	1.2	0.0	-1.8	1.4	-0.2	0.2	-0.9	-0.2
Illnesses of father: Heart disease	1.3	1.8	7.7	0.3	-1.2	-0.6	-0.8	0.1	1.2	0.8	-2.8	-0.9	-2.1
Illnesses of siblings: Diabetes	1.1	1.4	3.2	1.6	-0.5	1.4	-1.1	-1.8	1.0	0.7	-1.3	-0.4	-1.1
Smoking status: Previous	1.2	1.8	6.6	0.4	2.6	-1.6	-1.3	1.1	-0.3	1.8	-0.6	1.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	8.5	0.8	0.6	-2.9	-1.2	0.4	1.6	0.0	0.8	2.0	1.2
Whole body fat-free mass	0.8	4.5	18.6	-1.9	-0.1	-4.3	0.7	0.8	-0.1	0.8	2.0	3.5	2.4
Leg fat-free mass (right)	0.8	4.1	13.6	-1.1	0.2	-3.4	0.5	0.5	0.3	-0.3	2.2	3.7	3.0
Arm fat percentage (left)	0.6	2.2	6.7	-1.7	-0.6	2.6	0.1	-2.2	0.8	-1.8	-1.0	-0.9	-1.5
Average weekly red wine intake	1.3	1.9	4.7	0.7	0.9	-0.6	-2.1	0.2	1.4	1.6	-1.9	-0.5	-2.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.2	-0.1	-0.8	-1.4	1.1	-0.0	-0.7	-0.2	1.2	-0.0	1.5
Mood swings	0.2	0.4	2.3	1.5	-0.5	0.1	0.4	-0.2	0.3	-0.4	-0.6	0.5	-0.3
Loneliness, isolation	0.8	1.0	5.2	-0.6	-1.2	-0.0	-0.0	-2.3	1.1	-0.7	-1.2	0.4	-0.3
Long-standing illness, disability or infirmity	2.1	3.1	10.9	0.4	0.7	-0.2	-2.2	-1.6	3.1	0.5	-3.3	-0.0	-1.6
Ever had bowel cancer screening	0.3	0.3	0.9	0.9	0.1	0.0	-0.6	-0.7	0.5	0.1	-1.0	-0.4	-0.3
Diabetes diagnosed by doctor	2.2	3.6	10.4	0.5	1.0	-0.4	-2.4	-2.8	3.0	0.9	-3.2	0.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	6.1	2.5	0.7	2.1	0.3	-0.3	-0.1	-1.2	-0.7	-0.4	0.1
Friendships satisfaction	0.4	0.5	2.1	1.1	-0.7	-0.2	-0.0	-0.6	-0.5	1.4	0.4	0.3	0.0
Qualifications: nursing, teaching	0.4	0.7	1.5	1.2	-0.1	-1.2	0.0	0.8	0.3	1.0	0.5	0.6	1.2
Commuting to job workplace: Walk	0.9	1.0	3.2	0.1	1.4	-0.7	-1.8	-0.4	1.3	0.5	-1.5	-0.1	-0.5
Eye problems/disorders: Cataract	0.3	0.3	1.5	0.5	0.2	0.6	-0.4	0.9	1.2	0.3	0.0	0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	0.9	0.8	0.7	-0.8	1.5	0.4	1.3	0.9	0.1	0.0
Medication for cholesterol	1.0	1.6	7.8	-0.4	1.1	1.6	0.7	0.6	-1.2	-0.9	2.8	-0.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	0.3	-0.3	-0.7	0.2	0.7	0.2	0.3	-0.2	0.1	-0.2
Back pain experienced in last month	0.4	0.6	1.4	-0.9	-0.1	0.1	-0.1	0.8	0.1	0.9	1.2	1.2	1.0
Mineral and other dietary supplements	0.8	1.0	5.7	1.0	2.4	0.4	-0.0	1.5	-1.0	-0.5	-0.1	-0.0	-0.2
Breast cancer (self-reported)	1.9	2.2	8.8	2.3	3.0	0.5	-1.4	2.2	0.5	0.7	0.0	-0.4	-0.2
Asthma (self-reported)	1.6	3.2	12.8	0.2	-1.6	-0.2	-1.7	-3.6	2.9	0.9	-1.2	-1.2	-1.2
Osteoporosis (self-reported)	0.9	1.1	4.7	-0.7	1.6	-1.0	-0.1	-0.0	-0.0	-2.2	0.4	1.0	0.6
Osteoarthritis (self-reported)	0.3	0.4	3.0	-1.7	0.2	0.8	0.6	0.3	-0.3	-0.2	-0.0	-0.3	-0.3
Medication: Aspirin	1.4	1.8	9.6	1.1	-0.0	-0.4	-1.2	-0.1	1.1	1.8	-3.1	-0.1	-1.1
Medication: Gliclazide	0.9	1.0	5.2	-0.3	0.6	-0.9	-0.5	-0.4	0.6	0.8	-2.3	-0.8	-1.2
Illnesses of father: None of the above (group 1)	1.1	1.4	5.2	0.0	1.1	-0.4	0.6	1.3	-1.6	0.3	2.3	0.3	1.6
Smoking status: Current	1.0	1.6	8.2	-2.9	-0.8	-1.0	-0.6	0.6	1.2	1.5	-0.7	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	10.6	0.3	0.7	-0.7	-0.0	3.3	-1.5	0.6	1.7	0.3	0.0
Whole body water mass	0.8	4.7	19.7	-1.9	-0.1	-4.4	0.7	0.8	-0.0	0.8	2.0	3.5	2.4
Leg predicted mass (right)	0.8	4.1	14.0	-1.1	0.2	-3.4	0.5	0.6	0.3	-0.3	2.2	3.7	3.0
Arm fat mass (left)	0.3	1.2	5.6	-2.4	-1.0	0.7	0.7	-1.7	0.3	-1.2	-0.1	0.3	-0.5
Number of self-reported non-cancer illnesses	0.9	1.5	6.0	-0.5	-0.8	-1.7	-0.0	-1.7	1.1	0.1	-2.4	0.8	-0.8
Average weekly champagne plus white wine intake	0.4	0.6	2.5	-1.5	0.3	-1.6	-0.1	-0.8	-0.3	-0.1	-0.3	-0.4	-0.3
Miserableness	0.7	1.3	6.3	0.6	0.8	-1.1	-0.9	1.3	0.9	0.4	0.3	2.5	0.7
Guilty feelings	0.2	0.3	1.0	0.1	-0.7	0.3	0.2	-1.0	-0.7	-0.2	-0.4	-0.4	-0.5
Wears glasses or contact lenses	0.3	0.4	1.4	0.7	0.5	-0.5	1.2	0.6	-0.6	-0.8	-0.0	-0.2	0.4
Ever taken oral contraceptive pill	0.6	0.7	3.3	0.6	0.1	1.8	-0.8	0.0	0.2	1.0	-0.6	0.1	-0.9
Hearing aid user	0.6	0.7	1.7	0.3	0.1	0.9	-0.8	-1.2	0.6	0.5	-1.3	-0.6	-1.0
Mother’s age at death	0.6	0.7	2.4	1.2	-0.3	0.8	0.3	-1.6	0.6	-0.8	0.5	0.4	1.1
Financial situation satisfaction	0.8	0.9	2.9	1.3	-0.2	0.3	0.7	1.1	-1.2	0.9	0.4	1.7	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.8	4.1	0.8	0.1	-2.0	0.8	0.8	-0.7	0.1	-0.2	0.9	0.3
Commuting to job workplace: Public transport	0.5	0.6	2.9	0.3	-1.7	-0.7	0.0	-1.3	0.6	0.3	0.3	0.3	0.4
Eye problems/disorders: Glaucoma	1.6	1.9	7.5	-0.2	0.1	-0.6	1.9	-0.8	-1.9	-2.7	-0.7	-1.3	-0.9
Medication: Blood pressure	1.2	2.3	6.5	-0.6	-2.0	-2.1	-0.5	-1.6	0.5	1.4	-2.5	0.3	-1.7
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.4	-1.4	-1.1	0.9	1.4	-0.1	-0.1	-2.1	1.0	-0.5	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	9.3	-1.4	-3.0	-0.1	1.1	-1.5	0.1	0.3	0.6	-1.2	-0.2
High cholesterol (Self-reported)	3.4	6.0	17.6	-0.4	-3.2	0.0	1.1	-3.2	-0.1	-1.2	-4.2	-3.1	-3.0
Medication: Bendroflumethiazide	0.7	1.1	4.8	-1.1	-1.5	-2.2	0.8	-0.5	-0.6	-0.0	-0.8	-0.0	-0.9
Medication: Paracetamol	0.8	1.2	6.3	0.4	1.2	0.7	-0.6	2.5	0.0	1.5	1.1	0.3	-0.1
Medication: Lisinopril	0.5	0.6	2.2	-0.8	-0.6	-1.1	0.7	1.5	-0.1	0.1	-0.4	1.1	-0.0
Medication: Atorvastatin	0.6	0.7	2.8	0.7	-0.7	-1.4	-0.2	0.3	-0.3	0.3	-1.7	-0.3	-1.1
Illnesses of father: High blood pressure	0.2	0.3	1.6	0.4	-0.1	0.5	-0.4	-1.3	0.1	0.1	-0.1	0.5	0.1
Alcohol drinker status: Never	1.8	2.2	4.6	-1.8	-1.8	0.5	2.1	-0.7	-1.8	-1.4	0.6	-2.2	-0.6
Ever smoked	1.3	2.2	6.2	-1.1	2.3	-1.2	-1.8	1.4	0.7	2.5	-1.0	1.3	-0.1
Basal metabolic rate	0.6	3.5	13.4	-2.1	-0.2	-3.7	0.7	0.2	0.1	0.5	1.7	3.1	2.0
Leg fat percentage (left)	1.0	3.7	9.2	-2.5	-1.8	2.8	1.3	-3.0	-0.7	-1.3	-0.7	-1.2	-2.0
Arm fat-free mass (left)	0.8	4.1	13.8	-2.3	-0.9	-3.7	1.6	0.2	-0.9	1.0	1.9	3.0	2.0
Number of operations (self-reported)	4.0	5.9	14.7	0.6	2.3	-2.1	-3.4	0.5	3.3	2.7	0.1	3.8	2.1
Average weekly beer plus cider intake	0.9	1.3	4.4	-1.0	-0.3	0.1	1.2	-0.1	-0.5	-0.7	1.7	1.4	2.1
Irritability	1.1	1.9	6.9	0.3	1.7	-0.9	-2.6	-0.8	2.6	0.6	-0.6	-0.1	-0.6
Risk taking	1.1	1.6	3.5	1.5	-0.6	1.9	-1.2	-0.5	1.9	1.5	-0.2	0.8	1.2
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.8	0.9	1.8	-1.3	-2.0	1.3	1.5	1.7	-0.3	1.7	0.8
Fractured/broken bones in last 5 years	0.5	0.7	2.8	-0.1	0.6	-0.7	1.3	-0.6	-1.0	-1.7	0.4	0.3	0.1
Age started oral contraceptive pill	1.0	1.3	2.4	1.2	-1.6	1.0	1.3	-1.4	-1.2	-0.9	1.2	-0.5	0.7
Diastolic blood pressure, automated reading	2.3	7.0	19.5	-2.2	-4.4	-0.1	0.4	-2.5	-0.2	1.9	-3.5	-2.6	-4.0
Ever depressed for a whole week	1.2	1.4	4.9	1.3	0.5	-2.2	-0.8	0.9	0.9	1.1	-0.8	1.8	0.5
Unable to work because of sickness or disability	0.5	0.7	2.2	1.5	0.0	1.1	-0.2	-0.6	1.3	-0.4	-0.4	0.8	0.5
Commuting to job workplace: Cycle	0.8	1.0	2.8	1.4	1.2	1.2	-0.1	1.7	-0.8	0.7	0.4	0.9	0.3
Myopia	1.7	2.5	13.1	1.7	3.6	1.2	-0.6	1.1	-0.6	-1.5	0.9	0.9	1.3
Vascular/heart problems diagnosed by doctor	1.5	4.2	19.0	-0.2	1.4	2.3	0.7	0.8	0.0	-2.2	4.4	0.7	3.1
Cholesterol lowering medication	1.2	1.8	7.4	1.1	-1.3	1.0	0.8	-1.4	-0.1	-1.0	-2.7	-1.0	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	-0.2	-1.5	1.1	1.1	-1.6	0.1	-1.4	0.8	0.1	0.4
Pain experienced in last month	1.1	1.8	5.9	0.9	2.4	-1.2	-0.3	1.0	-0.2	-2.4	-1.8	-0.4	-0.7
Supplements: Calcium	0.6	0.7	2.3	1.3	-0.2	-1.5	-0.3	-1.0	1.1	-0.1	-0.6	0.4	0.2
Basal cell carcinoma (self-reported)	2.2	2.6	7.4	2.7	1.7	1.3	-2.5	-0.5	2.3	0.1	-1.1	0.9	-0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.6	0.9	0.4	-1.9	-1.0	1.5	-0.2	1.8	-1.5	0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	11.7	0.0	0.0	-1.3	-2.3	-0.0	3.4	1.1	-0.7	0.6	0.8
Heart disease (siblings)	0.8	0.9	3.5	-0.4	-0.5	-0.7	-1.3	-0.2	1.3	0.8	-1.9	-0.2	-0.8
Alcohol drinker status: Previous	1.1	1.2	3.6	1.1	-0.3	0.7	-1.6	-1.3	1.9	0.4	-1.1	-0.4	-1.0
Pack years of smoking	0.4	0.5	1.7	-1.1	-1.2	1.3	0.8	0.4	0.3	0.2	0.1	-0.0	0.1
Impedance of whole body	1.0	5.3	14.5	3.7	1.4	3.8	-1.1	-2.0	1.1	-2.5	-2.0	-2.1	-1.2
Leg fat mass (left)	0.4	1.7	7.2	-2.7	-1.5	1.0	1.1	-1.9	-0.3	-0.9	0.1	0.2	-0.8
Arm predicted mass (left)	0.8	4.1	12.5	-2.3	-0.8	-3.5	1.8	0.4	-1.0	0.7	2.1	3.1	2.0