TWAS hub - PRPF6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.218	0.0680	6.1e-04	0.007	NA	0.005	NA	0.024	1.3e-01	NA	1.6e-01	NA	2.2e-02
2	GTEx	Breast Mammary Tissue (Male)	0.226	0.1087	4.3e-02	0.020	NA	0.133	NA	0.079	1.1e-01	NA	5.5e-04	NA	7.0e-03
3	GTEx	Breast Mammary Tissue (Female)	0.103	0.0873	1.7e-01	-0.010	NA	-0.009	NA	-0.010	1.0e+00	NA	7.8e-01	NA	8.9e-01
4	GTEx	Cells EBV-transformed lymphocytes	0.267	0.0890	5.0e-03	0.189	NA	0.042	NA	0.133	9.3e-07	NA	1.6e-02	NA	4.1e-05
5	GTEx	Esophagus Mucosa	0.156	0.0540	1.6e-03	-0.004	NA	-0.004	NA	-0.004	7.8e-01	NA	9.6e-01	NA	9.8e-01
6	GTEx	Muscle Skeletal	0.146	0.0421	3.3e-05	0.002	NA	0.002	NA	0.009	2.0e-01	NA	1.7e-01	NA	3.6e-02
7	ROSMAP	Brain Pre-frontal Cortex	0.154	0.0359	3.0e-07	0.054	0.072	0.117	0.1	0.113	1.8e-07	1.4e-09	7.5e-15	9.4e-13	2.6e-14
8	TCGA	Lung Squamous Cell Carcinoma	0.056	0.0340	4.2e-03	0.013	0.019	0.018	NA	0.011	1.1e-02	2.8e-03	3.7e-03	NA	1.6e-02
9	TCGA	Prostate Adenocarcinoma	0.106	0.0425	8.1e-04	0.009	0.038	0.036	NA	0.021	3.8e-02	7.7e-05	9.9e-05	NA	2.7e-03
10	TCGA	Thyroid Carcinoma	0.050	0.0260	4.1e-03	0.001	0.022	0.003	NA	0.008	2.8e-01	2.6e-03	1.4e-01	NA	4.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Medication: Levothyroxine sodium	4.0	6.7	17.7	-1.5	-0.4	-2.5	-2.4	-1.0	2.5	0.6	-4.2	-3.4	-4.0
Number of operations (self-reported)	4.0	5.9	14.7	0.6	2.3	-2.1	-3.4	0.5	3.3	2.7	0.1	3.8	2.1
High cholesterol (Self-reported)	3.4	6.0	17.6	-0.4	-3.2	0.0	1.1	-3.2	-0.1	-1.2	-4.2	-3.1	-3.0
Diabetes (mother)	3.3	4.2	12.6	-1.8	-0.9	-1.1	-1.1	-1.9	1.0	-1.4	-3.3	-2.4	-3.5
Illness, injury, bereavement, stress in last 2 years	2.8	3.5	13.4	-1.4	-2.9	0.4	0.9	-0.7	-0.6	0.8	-0.7	-3.7	-2.8
Rheumatoid Arthritis	2.6	3.6	14.6	-0.3	-0.6	1.9	1.3	1.5	-1.8	0.2	3.8	1.2	2.9
Medication: Lansoprazole	2.6	2.9	9.3	0.1	0.7	1.0	-2.8	-0.7	3.0	1.7	-2.0	-0.3	-1.8
Length of working week for main job	2.5	2.7	10.0	-0.2	-1.6	-0.1	1.6	0.7	-0.8	-1.1	3.2	1.8	2.6
Illnesses of siblings	2.4	3.4	9.6	-0.7	0.4	-0.2	2.2	1.9	-1.4	-2.1	2.7	1.1	3.1
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	12.9	-0.7	-0.1	-1.4	-1.6	-1.0	1.6	0.4	-3.5	-3.6	-3.6
Shortness of breath walking on level ground	2.4	2.8	6.5	0.4	0.2	0.8	2.0	0.3	-1.6	-1.6	2.6	2.4	2.5
Prospective memory result	2.3	2.8	6.3	-1.3	-2.2	2.4	2.5	-0.1	-1.6	-1.8	1.7	-0.9	0.0
Loud music exposure frequency	2.3	2.5	8.5	-1.1	-1.0	0.1	0.9	0.8	-0.6	0.1	2.9	2.4	2.5
Heart disease (mother)	2.3	2.8	7.1	-0.5	-2.2	-0.6	0.6	-2.7	0.6	-1.1	-1.9	-2.3	-2.2
Diastolic blood pressure, automated reading	2.3	7.0	19.5	-2.2	-4.4	-0.1	0.4	-2.5	-0.2	1.9	-3.5	-2.6	-4.0
Medication: Metformin	2.2	3.1	10.1	-0.2	-0.1	-0.1	-2.4	-2.9	3.2	1.6	-2.0	0.3	-0.6
Had major operations	2.2	2.6	4.5	1.6	1.6	-1.3	-2.0	1.8	2.1	1.2	-0.4	2.1	1.1
Diabetes diagnosed by doctor	2.2	3.6	10.4	0.5	1.0	-0.4	-2.4	-2.8	3.0	0.9	-3.2	0.1	-1.0
Basal cell carcinoma (self-reported)	2.2	2.6	7.4	2.7	1.7	1.3	-2.5	-0.5	2.3	0.1	-1.1	0.9	-0.5
Neuroticism (2016)	2.1	3.0	7.9	-1.3	0.2	-2.8	-1.1	0.8	0.4	0.8	-2.4	-2.2	-2.7
Long-standing illness, disability or infirmity	2.1	3.1	10.9	0.4	0.7	-0.2	-2.2	-1.6	3.1	0.5	-3.3	-0.0	-1.6
Bipolar Disorder (2018)	2.0	3.2	9.2	1.6	2.8	1.1	-3.0	0.6	2.3	0.8	0.6	1.6	1.1
Relative age voice broke	2.0	3.0	9.4	0.4	-2.2	-0.2	0.3	-0.9	-0.1	0.8	-2.3	-3.0	-3.1
Hypothyroidism (self reported)	1.9	4.4	14.2	0.4	0.7	-1.8	-1.6	-1.3	1.2	-0.6	-3.8	-3.0	-3.3
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.6	1.9	-0.1	0.5	1.2	1.8	-1.0	-0.6	2.0	2.2	1.9
Medication: Simvastatin	1.9	2.8	13.3	0.5	-1.7	1.2	-0.2	-1.5	0.9	-0.0	-3.6	-1.8	-2.0
Pulse rate	1.9	3.3	14.6	0.5	-1.4	3.8	0.8	-0.4	-1.1	0.3	-0.5	-3.0	-2.2
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	14.4	0.7	1.7	1.8	-0.0	0.9	-0.1	-0.4	3.8	1.7	2.6
Breast cancer (self-reported)	1.9	2.2	8.8	2.3	3.0	0.5	-1.4	2.2	0.5	0.7	0.0	-0.4	-0.2
Cardiovascular Disease	1.8	5.9	21.8	-0.3	-3.4	-1.7	-0.2	-3.2	0.2	2.0	-4.7	-0.4	-2.8
Had other major operations	1.8	2.2	3.6	-0.9	1.6	-1.0	-1.9	1.0	1.7	1.9	1.4	1.4	1.5
Medication: Allopurinol	1.8	2.4	5.7	-1.2	1.4	-2.4	0.0	2.3	-0.9	-0.3	-1.9	-1.7	-1.3
Number of full sisters	1.8	2.2	5.2	-0.1	0.4	0.3	-2.1	-0.6	1.6	2.3	-2.1	-1.0	-2.0
Alcohol drinker status: Never	1.8	2.2	4.6	-1.8	-1.8	0.5	2.1	-0.7	-1.8	-1.4	0.6	-2.2	-0.6
Angina	1.7	2.2	10.8	-0.1	0.2	-2.4	-0.8	-0.1	0.2	0.3	-3.3	-0.5	-2.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	5.2	-0.3	-0.4	-0.4	2.3	0.5	-2.0	-1.6	2.0	0.2	1.2
Medication: Cholesterol lowering	1.7	2.7	15.2	0.3	-1.1	-1.8	-0.6	-1.1	0.8	0.1	-3.9	-1.2	-1.8
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	5.7	2.0	1.3	-1.8	-2.4	0.5	1.5	2.3	-0.2	1.8	0.9
Exposure to tobacco smoke outside home	1.7	2.3	13.0	1.0	-0.9	3.6	1.7	0.2	-1.0	-1.1	0.8	-1.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.6	1.7	1.9	-0.5	1.5	1.1	-1.2	-1.7	1.1	1.9	1.7
Angina (self-reported)	1.7	2.3	11.0	-0.2	-0.0	-2.4	-0.7	-0.3	0.1	0.5	-3.3	-0.6	-2.2
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.8	0.9	1.8	-1.3	-2.0	1.3	1.5	1.7	-0.3	1.7	0.8
Myopia	1.7	2.5	13.1	1.7	3.6	1.2	-0.6	1.1	-0.6	-1.5	0.9	0.9	1.3
Type 2 Diabetes (T2D) (2018)	1.6	3.0	10.6	0.4	1.1	-0.6	-2.0	-2.5	2.5	0.2	-3.2	0.5	-0.9
Systolic blood pressure, automated reading	1.6	4.5	21.5	-0.4	-1.7	-1.1	0.4	-2.3	-0.3	0.6	-4.6	-1.3	-3.4
Townsend deprivation index at recruitment	1.6	2.3	6.2	0.8	0.5	1.7	-2.5	-0.9	2.2	2.1	-0.5	1.5	0.1
Taking other prescription medications	1.6	2.5	6.4	-1.5	0.5	-1.0	-1.7	-1.8	2.2	-0.4	-2.5	-1.0	-1.7
Number of live births	1.6	2.3	7.0	-0.1	-1.7	0.2	1.2	-2.7	-0.5	-0.9	-1.7	-2.2	-1.7
Asthma	1.6	3.1	14.2	0.4	-1.9	-0.2	-1.5	-3.8	2.8	0.8	-0.9	-1.0	-0.9
Asthma (self-reported)	1.6	3.2	12.8	0.2	-1.6	-0.2	-1.7	-3.6	2.9	0.9	-1.2	-1.2	-1.2
Eye problems/disorders: Glaucoma	1.6	1.9	7.5	-0.2	0.1	-0.6	1.9	-0.8	-1.9	-2.7	-0.7	-1.3	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	11.7	0.0	0.0	-1.3	-2.3	-0.0	3.4	1.1	-0.7	0.6	0.8
Vitamin and mineral supplements	1.5	2.0	4.8	-1.3	0.9	1.1	-1.7	-1.5	1.4	-0.4	-2.2	-1.2	-1.7
Multivitamins +/- minerals	1.5	1.9	4.4	1.5	-1.5	-1.2	1.7	1.3	-1.0	0.2	2.1	1.1	1.1
Allergy	1.5	3.5	15.6	-1.4	-0.4	1.0	2.8	1.4	-4.0	-0.3	0.7	-1.9	-1.6
Diabetes (self-reported)	1.5	2.3	6.2	1.1	1.7	0.3	-2.0	-1.4	2.5	0.4	-2.4	0.4	-0.5
Medication: Ramipril	1.5	1.9	7.5	0.2	-1.6	-0.8	-0.9	-1.3	1.4	0.1	-2.7	-1.1	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.2	1.0	1.6	-0.3	-0.6	1.3	-0.1	0.4	1.5	2.3	1.9
Illnesses of mother	1.5	1.9	5.7	1.1	-0.0	0.7	0.6	1.8	-0.8	0.5	2.4	1.6	2.1
Medication: Ventolin 100micrograms inhaler	1.5	2.0	11.4	-0.4	-1.7	-0.6	0.9	-3.4	0.6	-1.6	0.1	-1.1	-0.2
Wheeze or whistling in the chest in last year	1.5	2.7	6.8	-1.7	-2.6	0.4	-1.1	-2.4	2.4	2.0	0.1	0.3	-0.2
Vascular/heart problems diagnosed by doctor	1.5	4.2	19.0	-0.2	1.4	2.3	0.7	0.8	0.0	-2.2	4.4	0.7	3.1
Breast Cancer	1.4	3.4	10.2	-1.1	-3.2	-2.6	0.7	0.1	0.8	0.7	-2.6	-1.7	-2.2
Crohns Disease (2012)	1.4	2.3	9.3	-1.1	-0.4	0.3	-1.8	-2.5	3.0	1.2	0.4	0.5	0.7
Respiratory disease	1.4	3.0	14.5	0.5	-2.0	0.5	-1.2	-3.8	2.7	1.4	-0.5	0.3	-0.3
Lung FVC	1.4	7.1	48.9	-0.9	2.8	-1.6	-0.4	7.0	-1.9	1.2	0.4	-2.1	-1.2
Current tobacco smoking	1.4	2.3	11.3	-3.4	-0.7	-1.0	-1.0	0.5	1.6	1.7	-1.1	-0.7	-1.4
Qualifications: CSEs or equivalent	1.4	1.8	8.2	-0.9	-2.9	-1.3	0.5	-1.8	0.2	1.7	0.9	0.6	0.2
Forced vital capacity (FVC)	1.4	5.4	29.3	1.3	3.5	-2.1	-1.1	5.4	-0.9	1.6	0.7	0.7	0.3
Blood clot in the leg (DVT)	1.4	1.7	9.1	-0.2	0.2	-1.5	-2.0	0.2	3.0	0.8	-0.8	0.5	0.7
Gout (self-reported)	1.4	2.0	6.0	-0.6	0.1	-2.2	-0.1	0.4	-0.2	-0.7	-2.4	-2.0	-2.0
Age at first live birth	1.4	2.4	4.7	2.2	0.7	-0.0	1.5	1.7	-1.1	-1.8	1.9	1.4	2.0
Chest pain or discomfort	1.4	2.0	5.8	-0.6	0.4	-0.5	-2.2	-1.4	2.4	1.6	-1.6	1.2	-0.4
Medication: Aspirin	1.4	1.8	9.6	1.1	-0.0	-0.4	-1.2	-0.1	1.1	1.8	-3.1	-0.1	-1.1
Verbal and Numeric Reasoning (VNR)	1.3	3.2	9.0	2.6	1.2	0.2	-2.7	-0.5	3.0	1.5	-1.9	-0.3	-1.0
Ovarian Cancer	1.3	1.8	6.2	-2.0	-1.2	0.8	-0.2	-0.4	0.6	0.7	-0.3	-2.1	-2.5
HbA1C	1.3	1.4	4.2	0.3	-1.2	0.2	-0.9	-0.5	0.8	1.0	-2.1	-1.4	-1.9
Mouth/teeth dental problems: Dentures	1.3	2.2	4.4	-2.1	-1.6	1.7	-0.8	-1.2	1.0	1.6	-0.6	-1.8	-1.6
Impedance of arm (left)	1.3	6.2	15.2	3.9	2.9	3.2	-2.4	-1.5	2.4	-2.8	-2.1	-1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.4	0.6	0.2	-1.3	-1.2	-1.0	1.0	2.1	-1.7	-0.8	-1.4
Medication: Aspirin	1.3	1.7	8.8	1.4	-0.2	-0.3	-1.1	-0.3	1.2	1.7	-3.0	0.2	-0.9
Illnesses of father: Heart disease	1.3	1.8	7.7	0.3	-1.2	-0.6	-0.8	0.1	1.2	0.8	-2.8	-0.9	-2.1
Average weekly red wine intake	1.3	1.9	4.7	0.7	0.9	-0.6	-2.1	0.2	1.4	1.6	-1.9	-0.5	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	6.1	2.5	0.7	2.1	0.3	-0.3	-0.1	-1.2	-0.7	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	9.3	-1.4	-3.0	-0.1	1.1	-1.5	0.1	0.3	0.6	-1.2	-0.2
Ever smoked	1.3	2.2	6.2	-1.1	2.3	-1.2	-1.8	1.4	0.7	2.5	-1.0	1.3	-0.1
Waist Hip Ratio (WHR)	1.2	5.2	15.6	1.9	-0.5	1.7	0.4	-3.9	0.2	-1.8	-3.5	-2.3	-2.9
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.7	0.4	1.6	-2.2	-0.3	1.4	0.6	1.0	-0.3	1.8	1.1
Supplements: Zinc	1.2	1.3	7.1	1.4	-0.0	0.2	-1.1	-0.0	0.7	2.7	-0.9	-0.5	-0.8
High blood pressure	1.2	3.3	11.5	0.1	-1.8	-2.0	-0.5	-0.9	-0.3	2.6	-3.4	-0.1	-2.5
Hayfever, allergic rhinitis or eczema	1.2	2.6	7.9	1.6	1.4	-1.0	-2.3	-0.3	2.8	-0.0	-0.5	2.0	1.7
Stomach or abdominal pain in last month	1.2	1.4	3.7	1.9	0.1	-0.7	-1.0	1.0	1.1	1.8	0.8	1.4	1.1
Past tobacco smoking	1.2	2.2	7.6	0.2	-2.8	1.3	1.5	-1.4	-0.2	-2.2	0.6	-1.7	-0.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	22.3	0.5	2.2	-2.1	-0.0	4.7	-1.7	1.2	1.6	1.0	0.9
Headache pain in last month	1.2	2.1	6.6	2.6	-0.8	1.5	-0.9	0.1	0.9	2.0	1.3	1.8	1.2
Birth weight	1.2	2.7	14.7	-1.7	3.8	-1.1	-0.4	1.8	0.2	-2.0	-0.0	-0.3	0.6
Medication: Blood pressure	1.2	2.0	5.9	-0.9	-1.3	-1.8	-0.7	0.8	0.2	1.8	-2.4	-0.6	-2.0
Medication: Omeprazole	1.2	1.4	3.6	0.5	0.1	0.7	1.1	-0.3	-0.5	-1.5	1.7	1.7	1.9
Pulse rate, automated reading	1.2	3.8	26.5	0.4	-0.7	5.2	1.2	-0.8	-1.0	-0.5	0.1	-2.5	-1.2
Age at last live birth	1.2	1.8	4.9	2.1	0.2	-0.3	0.5	1.0	-0.6	-0.8	1.6	1.9	2.2
Leg pain on walking	1.2	1.6	6.4	0.6	0.4	0.2	0.8	0.8	-0.4	0.7	1.5	2.5	2.1
Smoking status: Previous	1.2	1.8	6.6	0.4	2.6	-1.6	-1.3	1.1	-0.3	1.8	-0.6	1.1	0.3
Medication: Blood pressure	1.2	2.3	6.5	-0.6	-2.0	-2.1	-0.5	-1.6	0.5	1.4	-2.5	0.3	-1.7
Ever depressed for a whole week	1.2	1.4	4.9	1.3	0.5	-2.2	-0.8	0.9	0.9	1.1	-0.8	1.8	0.5
Cholesterol lowering medication	1.2	1.8	7.4	1.1	-1.3	1.0	0.8	-1.4	-0.1	-1.0	-2.7	-1.0	-1.5
Schizophrenia (2018)	1.1	2.4	7.0	1.0	1.0	0.4	0.7	-1.0	-1.2	-2.6	-1.6	-2.4	-1.9
Crohns Disease (2017)	1.1	2.5	8.2	-1.5	-1.5	1.0	-1.3	-2.5	2.9	1.5	-0.6	-0.5	-0.6
Allergy or Eczema	1.1	2.9	7.6	2.0	1.3	-1.1	-1.9	-1.2	2.8	-0.1	-0.9	2.2	1.9
Medication for hormone replacement therapy	1.1	1.2	4.2	1.1	1.3	-1.1	-0.8	2.0	0.4	1.7	-0.5	0.1	0.1
Heart attack	1.1	1.4	4.7	0.6	0.2	-2.2	-0.8	1.5	-0.3	1.8	-1.4	0.9	0.2
Impedance of arm (right)	1.1	5.2	12.5	3.5	2.1	3.3	-2.1	-1.9	2.3	-2.5	-1.7	-0.9	-0.4
Pulse wave peak to peak time	1.1	1.3	2.5	-1.4	0.2	-1.1	1.4	0.9	-1.2	-1.2	1.3	0.5	1.6
Emphysema/chronic bronchitis	1.1	1.2	4.5	-0.2	-1.3	2.1	1.2	-0.2	-0.8	-0.3	1.4	0.9	1.2
Hypertension (Self-reported)	1.1	2.9	9.9	-0.2	-1.9	-2.1	-0.2	-0.9	-0.6	2.1	-3.1	-0.2	-2.4
Illnesses of siblings: Diabetes	1.1	1.4	3.2	1.6	-0.5	1.4	-1.1	-1.8	1.0	0.7	-1.3	-0.4	-1.1
Illnesses of father: None of the above (group 1)	1.1	1.4	5.2	0.0	1.1	-0.4	0.6	1.3	-1.6	0.3	2.3	0.3	1.6
Irritability	1.1	1.9	6.9	0.3	1.7	-0.9	-2.6	-0.8	2.6	0.6	-0.6	-0.1	-0.6
Risk taking	1.1	1.6	3.5	1.5	-0.6	1.9	-1.2	-0.5	1.9	1.5	-0.2	0.8	1.2
Pain experienced in last month	1.1	1.8	5.9	0.9	2.4	-1.2	-0.3	1.0	-0.2	-2.4	-1.8	-0.4	-0.7
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.6	0.9	0.4	-1.9	-1.0	1.5	-0.2	1.8	-1.5	0.9	0.2
Alcohol drinker status: Previous	1.1	1.2	3.6	1.1	-0.3	0.7	-1.6	-1.3	1.9	0.4	-1.1	-0.4	-1.0
Coronary Artery Disease (CAD)	1.0	1.2	5.6	-1.8	-2.4	-1.3	0.7	-0.7	0.0	0.0	0.0	0.0	0.0
Hand grip strength (left)	1.0	2.7	10.8	-2.0	-0.6	-3.3	2.1	0.7	-2.4	1.1	0.2	0.6	-0.1
Maternal smoking around birth	1.0	1.4	5.2	-1.2	-2.3	-0.2	1.8	-1.6	-0.6	-0.7	-0.1	-0.5	-0.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.9	-1.5	-0.1	-2.2	0.1	-0.4	-0.1	1.4	-0.7	-0.2	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	6.5	-2.1	-2.5	0.0	-0.1	-1.4	0.8	0.1	-0.5	-1.1	-0.8
Hair/balding pattern: Pattern 2	1.0	1.3	2.7	-1.2	0.5	-1.6	-1.7	-1.3	1.6	-0.0	-0.9	-0.3	-0.9
Pain all over the body in last month	1.0	1.1	3.7	-1.3	-1.9	0.6	0.9	-1.2	0.2	0.2	-0.7	-0.8	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	12.1	0.2	1.8	-3.0	-0.7	3.5	-1.0	1.3	1.2	1.3	0.8
Pulse wave Arterial Stiffness index	1.0	1.2	2.0	1.3	-0.2	0.7	-1.3	-1.0	1.1	1.2	-1.3	-0.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	4.5	0.6	1.1	-2.1	-0.2	2.1	0.0	0.9	-0.3	2.1	0.5
High blood pressure (siblings)	1.0	1.5	5.6	0.6	0.2	-0.7	-1.0	-0.7	0.3	1.6	-1.8	-1.0	-2.4
Forced vital capacity (FVC), Best measure	1.0	3.8	14.3	0.8	2.6	-3.3	-1.2	3.8	-0.6	1.2	0.7	1.0	0.4
Leg fat percentage (right)	1.0	3.7	7.7	-2.8	-1.5	2.7	0.8	-2.6	-0.3	-0.9	-1.2	-1.5	-2.7
Worry too long after embarrassment	1.0	1.6	9.7	-2.2	0.8	-3.1	-0.5	0.7	0.1	-0.0	-0.6	0.2	-0.2
Medication for cholesterol	1.0	1.6	7.8	-0.4	1.1	1.6	0.7	0.6	-1.2	-0.9	2.8	-0.1	1.1
Smoking status: Current	1.0	1.6	8.2	-2.9	-0.8	-1.0	-0.6	0.6	1.2	1.5	-0.7	-0.4	-1.0
Leg fat percentage (left)	1.0	3.7	9.2	-2.5	-1.8	2.8	1.3	-3.0	-0.7	-1.3	-0.7	-1.2	-2.0
Age started oral contraceptive pill	1.0	1.3	2.4	1.2	-1.6	1.0	1.3	-1.4	-1.2	-0.9	1.2	-0.5	0.7
Impedance of whole body	1.0	5.3	14.5	3.7	1.4	3.8	-1.1	-2.0	1.1	-2.5	-2.0	-2.1	-1.2
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.0	2.2	2.5	0.1	-2.6	1.0	2.0	1.9	-0.6	-0.6	-0.4
Prostate Cancer	0.9	1.2	3.6	0.7	-0.3	-1.9	-0.7	-1.1	0.9	1.8	0.1	1.4	0.6
Fasting Glucose	0.9	1.0	3.5	0.6	1.4	-1.9	-0.9	1.2	-0.4	0.9	-1.0	0.1	-0.5
Smoking Status	0.9	2.3	5.1	-1.9	0.3	-1.8	-2.0	0.1	2.0	2.3	-1.2	0.2	-0.9
Age when periods started (menarche)	0.9	2.2	8.5	2.9	-0.3	2.5	0.7	0.3	-1.2	0.7	1.7	0.6	1.3
Serious illness, injury or assault to yourself	0.9	1.1	4.1	1.2	2.0	-0.2	-0.6	1.2	0.0	-0.3	-0.1	1.9	0.6
Trunk fat-free mass	0.9	5.0	23.8	-2.1	-0.2	-4.9	0.6	0.8	-0.1	1.5	1.8	3.3	2.1
Trunk predicted mass	0.9	5.0	23.8	-2.0	-0.1	-4.9	0.6	0.8	-0.1	1.4	1.8	3.4	2.1
Medication: Amlodipine	0.9	1.2	3.5	1.2	0.1	0.0	-1.2	1.9	0.5	1.6	-1.1	0.3	-1.2
Chronic bronchitis/emphysema (mother)	0.9	1.0	4.8	0.4	0.2	0.1	-0.1	-2.2	0.9	-1.8	-0.8	-0.2	-0.9
Comparative body size at age 10	0.9	2.5	6.1	-2.5	0.4	-0.4	2.3	1.2	-2.3	-2.5	0.5	0.2	0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.8	-1.9	-0.2	-1.8	-0.4	-1.2	1.1	-0.7	-0.8	0.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.5	0.1	-1.9	1.2	0.0	-1.8	1.4	-0.2	0.2	-0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	8.5	0.8	0.6	-2.9	-1.2	0.4	1.6	0.0	0.8	2.0	1.2
Commuting to job workplace: Walk	0.9	1.0	3.2	0.1	1.4	-0.7	-1.8	-0.4	1.3	0.5	-1.5	-0.1	-0.5
Osteoporosis (self-reported)	0.9	1.1	4.7	-0.7	1.6	-1.0	-0.1	-0.0	-0.0	-2.2	0.4	1.0	0.6
Medication: Gliclazide	0.9	1.0	5.2	-0.3	0.6	-0.9	-0.5	-0.4	0.6	0.8	-2.3	-0.8	-1.2
Number of self-reported non-cancer illnesses	0.9	1.5	6.0	-0.5	-0.8	-1.7	-0.0	-1.7	1.1	0.1	-2.4	0.8	-0.8
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.4	-1.4	-1.1	0.9	1.4	-0.1	-0.1	-2.1	1.0	-0.5	0.3
Average weekly beer plus cider intake	0.9	1.3	4.4	-1.0	-0.3	0.1	1.2	-0.1	-0.5	-0.7	1.7	1.4	2.1
Irritable Bowel Disease (IBD)	0.8	1.9	7.0	-2.0	-1.3	1.5	-0.9	-1.1	2.6	0.8	0.7	-0.6	0.2
Mean Putamen Volume	0.8	1.0	3.2	0.7	1.8	1.1	0.6	-0.0	-1.2	-1.5	-0.5	0.4	0.5
HDL Cholesterol	0.8	1.4	3.7	0.6	1.8	-0.7	0.3	1.9	-1.2	0.7	1.7	0.1	1.0
Blood White Count	0.8	6.1	20.2	2.1	-1.2	1.2	-1.4	-2.3	1.4	1.8	1.6	4.5	4.3
Impedance of leg (right)	0.8	3.8	10.2	1.6	0.3	3.2	-0.6	-1.9	0.4	-0.2	-2.4	-2.7	-2.8
Had menopause	0.8	1.0	3.7	-0.1	-0.3	0.1	1.5	-0.2	-0.9	-1.9	-0.4	-1.7	-0.2
Fluid intelligence score	0.8	1.6	7.1	2.7	0.4	0.3	-1.4	0.4	1.6	0.4	-1.4	-1.1	-0.9
Depression (self-reported)	0.8	0.9	2.4	1.5	1.4	-1.2	-0.1	0.7	-0.0	-1.1	-1.1	-0.1	-0.5
Birth weight of first child	0.8	1.5	3.3	-1.4	1.8	-0.2	-1.4	0.7	1.7	0.3	1.5	0.9	1.3
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.9	0.1	0.8	0.5	0.8	0.6	-1.2	0.9	1.4	1.7	0.6
Medication: Paracetamol	0.8	1.3	6.0	0.8	0.7	0.4	-0.2	2.5	-0.4	1.6	1.3	0.9	0.1
Glaucoma (self-reported)	0.8	0.9	3.7	-1.0	1.0	-0.8	0.7	-0.6	-1.2	-1.9	-0.4	-0.1	-0.0
Body fat percentage	0.8	3.1	8.5	-2.0	-1.2	2.9	0.4	-2.9	0.5	-1.8	-1.2	-1.2	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	5.6	-0.2	0.6	0.5	0.3	0.5	0.1	-0.4	1.1	2.4	1.5
Arm predicted mass (right)	0.8	4.1	15.7	-2.3	-0.7	-4.0	1.7	0.7	-1.0	0.7	1.8	2.7	1.9
Overall health rating	0.8	1.6	3.6	-1.0	-0.7	1.6	-1.1	-1.2	1.8	0.6	-1.9	-0.4	-1.5
Whole body fat-free mass	0.8	4.5	18.6	-1.9	-0.1	-4.3	0.7	0.8	-0.1	0.8	2.0	3.5	2.4
Leg fat-free mass (right)	0.8	4.1	13.6	-1.1	0.2	-3.4	0.5	0.5	0.3	-0.3	2.2	3.7	3.0
Loneliness, isolation	0.8	1.0	5.2	-0.6	-1.2	-0.0	-0.0	-2.3	1.1	-0.7	-1.2	0.4	-0.3
Mineral and other dietary supplements	0.8	1.0	5.7	1.0	2.4	0.4	-0.0	1.5	-1.0	-0.5	-0.1	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	10.6	0.3	0.7	-0.7	-0.0	3.3	-1.5	0.6	1.7	0.3	0.0
Whole body water mass	0.8	4.7	19.7	-1.9	-0.1	-4.4	0.7	0.8	-0.0	0.8	2.0	3.5	2.4
Leg predicted mass (right)	0.8	4.1	14.0	-1.1	0.2	-3.4	0.5	0.6	0.3	-0.3	2.2	3.7	3.0
Financial situation satisfaction	0.8	0.9	2.9	1.3	-0.2	0.3	0.7	1.1	-1.2	0.9	0.4	1.7	0.7
Medication: Paracetamol	0.8	1.2	6.3	0.4	1.2	0.7	-0.6	2.5	0.0	1.5	1.1	0.3	-0.1
Arm fat-free mass (left)	0.8	4.1	13.8	-2.3	-0.9	-3.7	1.6	0.2	-0.9	1.0	1.9	3.0	2.0
Commuting to job workplace: Cycle	0.8	1.0	2.8	1.4	1.2	1.2	-0.1	1.7	-0.8	0.7	0.4	0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.7	-0.2	-1.5	1.1	1.1	-1.6	0.1	-1.4	0.8	0.1	0.4
Heart disease (siblings)	0.8	0.9	3.5	-0.4	-0.5	-0.7	-1.3	-0.2	1.3	0.8	-1.9	-0.2	-0.8
Arm predicted mass (left)	0.8	4.1	12.5	-2.3	-0.8	-3.5	1.8	0.4	-1.0	0.7	2.1	3.1	2.0
Bipolar Disorder or Schizophrenia	0.7	1.6	6.5	1.8	2.5	1.0	-1.4	-0.5	0.5	-1.5	-0.5	-0.7	-0.6
Depression (Nagel 2018)	0.7	1.1	2.8	-1.7	-0.9	-1.7	1.1	-0.9	-0.4	-1.4	-0.4	0.1	0.1
Alzheimer’s Disease (in father)	0.7	0.7	2.0	-1.1	-1.4	-0.4	1.4	0.4	-0.7	0.0	0.6	0.8	0.8
Ulcerative Colitis (UC)	0.7	1.4	3.8	-1.4	-0.9	1.6	-0.2	1.0	1.5	0.7	1.9	-0.3	1.0
Triglycerides	0.7	1.2	2.9	1.4	-1.3	1.7	0.3	-1.4	0.4	-0.3	-1.2	-0.3	-1.2
Heel T-Score	0.7	5.6	20.3	1.5	1.5	-0.2	-3.6	3.3	1.4	4.5	-1.6	1.6	-0.0
Systolic Blood Pressure	0.7	3.8	17.8	-0.1	-2.1	-2.6	0.3	-0.6	-0.5	1.4	-4.2	0.6	-2.3
Lung FEV1/FVC ratio	0.7	3.6	10.0	-2.6	-2.2	-0.2	2.8	1.5	-3.2	0.3	1.7	-0.6	0.2
Trunk fat percentage	0.7	2.9	8.5	-1.4	-1.0	2.8	0.1	-2.9	1.0	-2.0	-1.2	-1.1	-1.4
Hand grip strength (right)	0.7	1.9	6.8	-0.9	-0.7	-2.6	1.8	0.8	-2.1	1.2	0.4	0.8	-0.1
Medication: Atenolol	0.7	0.8	3.1	-1.2	-0.5	-1.8	0.4	-0.1	-0.8	-0.4	-1.4	0.5	-0.6
Impedance of leg (left)	0.7	3.5	10.1	2.2	-0.2	3.2	-0.0	-2.3	-0.2	-0.9	-1.8	-2.5	-2.0
Father’s age at death	0.7	1.0	4.1	-0.6	-1.1	0.3	0.4	-1.3	0.4	-0.9	-0.7	-2.0	-0.9
Falls in the last year	0.7	1.0	4.6	-0.4	-0.3	0.9	-0.9	-2.2	1.0	0.4	-1.3	0.1	-0.6
Happiness	0.7	0.9	2.0	-0.1	-0.9	0.5	0.7	1.4	-0.7	1.4	1.1	0.8	0.8
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.1	0.7	-0.4	-2.0	-1.6	-1.4	1.2	1.8	-0.7	-0.6	-0.7
Breastfed as a baby	0.7	0.9	3.8	0.0	-0.0	-0.4	-1.0	-1.9	0.9	0.6	-1.1	-0.9	-0.6
Arm fat-free mass (right)	0.7	3.6	15.1	-2.3	-0.6	-3.9	1.3	0.8	-0.7	1.1	1.6	2.5	1.6
Number of full brothers	0.7	0.9	1.5	0.3	0.7	0.8	-1.2	-1.2	1.2	1.1	-0.8	-0.8	-0.8
Supplements: Vitamin C	0.7	0.8	3.2	0.9	-1.2	-1.1	0.8	-0.1	-0.7	1.8	-0.1	-0.2	0.3
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.2	-0.1	-0.8	-1.4	1.1	-0.0	-0.7	-0.2	1.2	-0.0	1.5
Miserableness	0.7	1.3	6.3	0.6	0.8	-1.1	-0.9	1.3	0.9	0.4	0.3	2.5	0.7
Medication: Bendroflumethiazide	0.7	1.1	4.8	-1.1	-1.5	-2.2	0.8	-0.5	-0.6	-0.0	-0.8	-0.0	-0.9
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-1.3	-0.9	1.0	1.3	0.4	-0.8	-0.9	0.9	-0.4	-0.1
LDL Cholesterol	0.6	0.9	2.3	1.5	0.3	-0.8	0.6	0.4	-0.9	-1.5	-1.5	0.0	-0.9
Neuroticism	0.6	1.5	9.4	-1.4	0.1	-3.1	-0.5	-0.2	0.2	-0.3	-1.3	-0.3	-1.3
Number of treatments/medications taken	0.6	1.1	2.8	-0.8	-0.1	-0.0	-1.4	-0.5	1.6	1.2	-1.7	-0.1	-1.1
Severe depression (siblings)	0.6	0.6	4.5	0.6	-0.3	0.5	-0.1	-2.1	0.7	0.2	-0.2	0.7	0.3
Leg fat-free mass (left)	0.6	3.3	10.9	-1.7	0.4	-3.2	0.2	0.5	0.7	-0.1	1.6	3.3	2.3
Average weekly fortified wine intake	0.6	0.7	2.1	-1.5	-1.0	-0.2	1.2	-0.7	-1.1	-0.2	-0.1	-0.4	-0.5
Sitting height	0.6	4.0	13.2	1.2	1.9	-3.6	-1.2	1.8	1.2	0.9	0.9	3.1	2.1
Leg predicted mass (left)	0.6	3.3	11.2	-1.6	0.4	-3.1	0.3	0.4	0.6	-0.2	1.7	3.4	2.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.2	-0.3	0.7	-1.3	-0.6	0.0	0.6	0.3	0.0	1.8	0.7
Qualifications: None of the above	0.6	1.4	4.7	-1.5	-0.7	2.2	1.4	0.3	-1.4	-1.3	0.4	-0.3	-0.2
Mouth/teeth dental problems	0.6	1.0	3.9	1.0	0.9	-1.1	0.5	2.0	-0.6	0.1	-0.1	1.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.4	-0.8	-1.6	-0.0	1.0	-1.2	0.3	-1.4	-0.1	-0.4	0.1
Arm fat percentage (right)	0.6	2.3	6.3	-1.8	-1.0	2.5	0.2	-2.5	0.8	-1.5	-0.9	-0.8	-1.5
Time employed in main current job	0.6	0.7	1.8	-0.9	-0.6	-0.8	0.9	-0.1	-0.8	-1.3	1.1	0.3	0.6
Standing height	0.6	5.6	21.8	1.4	1.5	-4.7	-0.4	-0.3	1.4	-1.0	1.1	3.8	3.3
Peak expiratory flow (PEF)	0.6	1.4	3.7	-0.6	1.1	-1.9	-0.4	1.9	-0.3	1.2	0.9	1.1	1.1
Health satisfaction	0.6	0.8	3.4	-0.0	1.8	0.8	0.5	1.5	-0.9	0.1	-0.2	0.4	0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	3.5	1.0	1.0	-0.2	0.3	-0.3	-0.6	-1.9	1.3	-0.0	1.5
Comparative height size at age 10	0.6	3.1	22.2	-1.1	0.8	-4.7	0.6	-0.8	0.6	-1.7	-0.7	1.3	0.8
Arm fat percentage (left)	0.6	2.2	6.7	-1.7	-0.6	2.6	0.1	-2.2	0.8	-1.8	-1.0	-0.9	-1.5
Ever taken oral contraceptive pill	0.6	0.7	3.3	0.6	0.1	1.8	-0.8	0.0	0.2	1.0	-0.6	0.1	-0.9
Hearing aid user	0.6	0.7	1.7	0.3	0.1	0.9	-0.8	-1.2	0.6	0.5	-1.3	-0.6	-1.0
Mother’s age at death	0.6	0.7	2.4	1.2	-0.3	0.8	0.3	-1.6	0.6	-0.8	0.5	0.4	1.1
Tinnitus: Yes, now most or all of the time	0.6	0.8	4.1	0.8	0.1	-2.0	0.8	0.8	-0.7	0.1	-0.2	0.9	0.3
Medication: Atorvastatin	0.6	0.7	2.8	0.7	-0.7	-1.4	-0.2	0.3	-0.3	0.3	-1.7	-0.3	-1.1
Basal metabolic rate	0.6	3.5	13.4	-2.1	-0.2	-3.7	0.7	0.2	0.1	0.5	1.7	3.1	2.0
Supplements: Calcium	0.6	0.7	2.3	1.3	-0.2	-1.5	-0.3	-1.0	1.1	-0.1	-0.6	0.4	0.2
Depressed Affect (Nagel 2018)	0.5	1.0	2.9	-1.0	-1.7	-1.1	-0.0	-1.2	0.9	0.2	-1.1	-0.3	-1.3
Age at First Birth	0.5	0.7	2.8	1.7	1.1	0.3	0.3	0.3	-0.3	-1.2	0.2	1.0	0.6
Lupus	0.5	0.8	3.5	-0.4	1.9	-1.0	-0.5	1.2	-0.2	0.2	-0.3	1.0	0.3
Schizophrenia (2014)	0.5	1.2	2.8	1.0	1.6	0.4	-0.4	-0.1	-0.1	-1.7	-0.9	-1.7	-1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	4.0	-0.7	-1.0	0.5	-0.1	-2.0	0.0	0.1	0.0	0.0	0.0
Ulcerative Colitis	0.5	0.7	3.1	-1.8	-0.8	0.2	-0.2	-0.7	1.1	-0.8	-0.0	-0.9	-0.2
Blood Eosinophil Count	0.5	3.9	15.0	1.4	1.2	1.9	-0.7	-3.9	1.9	-1.9	-0.1	1.9	2.4
Sensitivity / hurt feelings	0.5	0.8	2.8	-0.4	1.6	-1.7	-0.6	0.5	0.2	-0.3	-0.9	1.0	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-0.5	-0.7	-0.7	1.1	0.5	0.2	-1.0	0.3	1.3	1.2
Relative age of first facial hair	0.5	1.1	4.8	1.3	-2.2	0.3	0.7	-0.2	-0.2	0.1	-0.6	-1.4	-1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.4	1.3	-0.2	0.1	0.1	-0.1	0.4	0.0	0.0	1.5	1.1
Medication: Co-codamol	0.5	0.5	1.1	0.5	0.9	0.9	-0.5	0.7	0.4	0.7	-1.0	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	6.5	0.6	-0.9	-0.4	-1.2	-0.6	0.7	2.5	-0.9	-0.0	-0.6
Supplements: Glucosamine	0.5	0.7	2.8	-0.5	-1.7	0.3	0.8	-1.1	-0.3	0.2	0.9	0.9	0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	2.6	-0.6	0.4	0.6	-0.1	-1.6	0.2	-0.8	-0.6	-0.6	-0.9
Waist circumference	0.5	1.7	7.5	-2.1	-1.3	0.6	0.9	-2.7	0.2	-1.0	-0.8	0.2	-1.0
Number of incorrect matches in round	0.5	0.8	2.4	-0.3	-0.4	-0.6	0.9	1.3	-1.5	0.2	1.2	-0.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	3.5	-0.5	0.4	0.6	-1.2	-0.1	1.4	0.7	-0.9	1.9	-0.0
Lung cancer (father)	0.5	0.6	3.0	0.3	-0.1	-0.6	0.1	0.7	-0.9	1.7	0.5	-0.8	-0.3
Pulse wave reflection index	0.5	0.6	1.6	1.3	-0.4	-1.1	-0.6	-0.6	0.6	0.8	0.1	0.9	0.1
Alcohol intake frequency.	0.5	1.2	3.8	1.8	0.1	2.0	-0.1	0.2	-0.3	-1.4	1.1	1.0	0.7
Family relationship satisfaction	0.5	0.7	3.6	1.2	0.2	-0.4	-0.0	0.6	-0.1	0.7	-0.1	1.9	0.8
Knee pain experienced in last month	0.5	0.7	2.4	-0.9	-0.1	0.3	-0.4	-0.6	0.8	1.2	0.7	1.6	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	0.9	0.8	0.7	-0.8	1.5	0.4	1.3	0.9	0.1	0.0
Commuting to job workplace: Public transport	0.5	0.6	2.9	0.3	-1.7	-0.7	0.0	-1.3	0.6	0.3	0.3	0.3	0.4
Medication: Lisinopril	0.5	0.6	2.2	-0.8	-0.6	-1.1	0.7	1.5	-0.1	0.1	-0.4	1.1	-0.0
Fractured/broken bones in last 5 years	0.5	0.7	2.8	-0.1	0.6	-0.7	1.3	-0.6	-1.0	-1.7	0.4	0.3	0.1
Unable to work because of sickness or disability	0.5	0.7	2.2	1.5	0.0	1.1	-0.2	-0.6	1.3	-0.4	-0.4	0.8	0.5
Neuroticism (Nagel 2018)	0.4	0.9	5.1	-0.8	-0.9	-2.3	-0.4	-0.7	0.7	0.3	-1.0	-0.2	-0.8
Schizophrenia vs Biploar Disorder	0.4	0.6	2.4	0.4	-0.6	-0.3	1.6	-0.4	-0.8	-1.4	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.4	0.6	2.4	-0.5	-0.7	0.3	0.2	0.1	0.1	0.3	0.4	1.5	1.5
Chronotype (morning person)	0.4	0.9	2.2	-0.8	1.5	-1.5	-0.2	0.1	-0.4	-0.8	-1.0	-1.0	-0.8
Pack years adult smoking proportion	0.4	0.6	1.6	-1.1	-1.3	0.7	1.1	0.6	0.0	0.2	0.7	0.4	0.6
Fed-up feelings	0.4	0.7	2.7	-0.8	-1.1	0.1	-0.6	-0.5	1.0	1.6	-0.4	0.5	-0.9
High blood pressure (mother)	0.4	0.5	1.0	1.0	0.5	-0.4	-1.0	-0.8	0.3	0.9	-0.2	0.9	-0.4
Body mass index (BMI)	0.4	1.6	9.4	-3.1	-1.6	0.7	1.2	-1.0	-0.6	-0.3	0.4	0.0	-0.7
Trunk fat mass	0.4	1.7	6.3	-2.0	-1.0	1.2	0.4	-2.5	0.8	-1.7	-0.6	-0.2	-0.8
Exposure to tobacco smoke at home	0.4	0.5	2.0	-0.9	-0.2	1.4	0.7	0.0	-0.6	0.2	0.9	-0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	0.3	0.0	-0.7	0.6	-1.1	-0.8	-0.6	1.1	-0.1	0.7
Qualifications: College or University degree	0.4	1.1	4.1	2.0	0.7	-0.5	-1.7	0.7	1.7	0.2	0.1	-0.3	0.3
Neck or shoulder pain in last month	0.4	0.6	1.5	-1.2	0.3	-0.9	-1.1	0.3	1.1	1.0	0.2	0.5	-0.2
Whole body fat mass	0.4	1.8	5.8	-2.4	-1.5	1.0	0.8	-2.4	0.4	-1.2	-0.3	-0.1	-0.8
Leg fat mass (right)	0.4	1.6	8.0	-2.8	-1.4	0.9	1.0	-1.7	-0.1	-0.7	-0.2	-0.0	-1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.1	0.1	0.4	0.8	-0.0	-0.4	-1.2	0.9	0.8	0.6
Friendships satisfaction	0.4	0.5	2.1	1.1	-0.7	-0.2	-0.0	-0.6	-0.5	1.4	0.4	0.3	0.0
Qualifications: nursing, teaching	0.4	0.7	1.5	1.2	-0.1	-1.2	0.0	0.8	0.3	1.0	0.5	0.6	1.2
Back pain experienced in last month	0.4	0.6	1.4	-0.9	-0.1	0.1	-0.1	0.8	0.1	0.9	1.2	1.2	1.0
Average weekly champagne plus white wine intake	0.4	0.6	2.5	-1.5	0.3	-1.6	-0.1	-0.8	-0.3	-0.1	-0.3	-0.4	-0.3
Pack years of smoking	0.4	0.5	1.7	-1.1	-1.2	1.3	0.8	0.4	0.3	0.2	0.1	-0.0	0.1
Leg fat mass (left)	0.4	1.7	7.2	-2.7	-1.5	1.0	1.1	-1.9	-0.3	-0.9	0.1	0.2	-0.8
Worry (Nagel 2018)	0.3	0.6	2.7	-0.0	-0.8	-1.6	0.4	0.2	-0.3	-0.6	-0.7	-1.1	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.6	-0.0	-0.9	1.2	0.2	-0.8	0.2	-0.3	0.4	0.1	0.7
Blood Platelet Count	0.3	3.2	21.8	-0.0	-2.3	-1.6	-0.1	-4.7	1.2	-0.6	-0.7	0.0	0.6
BMI	0.3	1.9	8.9	-3.0	-2.0	0.5	1.1	-1.3	-0.9	0.5	1.3	0.7	-0.3
Height	0.3	5.2	21.4	1.2	1.8	-4.6	-1.9	-1.8	3.3	-0.7	-2.0	1.6	0.6
Average weekly spirits intake	0.3	0.4	0.9	-0.7	0.2	0.8	1.0	-0.1	-1.0	-0.3	0.4	0.8	0.7
Hearing difficulty/problems: Yes	0.3	0.5	2.2	-0.4	-0.4	-1.2	-0.2	-0.6	-0.2	1.5	0.4	0.4	0.6
Ever had hysterectomy (womb removed)	0.3	0.4	2.6	-0.4	0.6	-0.4	0.0	-0.4	-0.5	1.6	-0.1	0.1	-0.5
Diabetes (father)	0.3	0.4	1.7	-0.4	-0.0	1.0	0.4	-1.3	-0.1	-0.9	0.4	0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.2	-0.5	0.2	-1.5	-0.1	0.2	0.3	-0.6	-0.6	0.6	-0.1
Nervous feelings	0.3	0.5	1.3	0.8	0.5	-0.8	-0.1	0.4	-0.5	-0.5	-0.7	-1.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	4.2	0.4	-1.0	-0.8	-0.7	0.0	0.6	2.0	-0.5	-0.2	-0.3
Weight	0.3	1.4	5.3	-2.3	-0.6	-1.3	0.9	-1.0	0.1	-0.8	0.7	1.7	0.8
Hip circumference	0.3	1.2	8.0	-2.8	-0.9	-0.5	0.3	-1.0	0.5	-0.1	0.7	0.9	0.2
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-0.6	-0.8	0.8	0.5	-0.5	-0.9	-0.6	0.9	0.5	0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-0.7	0.3	-0.3	-1.2	0.5	1.0	0.4	0.1	-0.5	-0.4
Noisy workplace	0.3	0.4	1.7	0.2	0.2	0.6	0.5	0.1	-0.3	-0.4	0.9	1.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.9	-0.1	0.4	0.8	0.1	0.4	-0.4	-0.1	0.5	1.4	-0.1
Arm fat mass (right)	0.3	1.2	4.9	-2.2	-0.9	0.7	0.7	-1.8	0.2	-1.1	0.0	0.5	-0.4
Number of children fathered	0.3	0.3	1.0	-1.0	-0.6	-1.0	0.5	-0.0	-0.4	0.2	-0.2	-0.2	-0.3
Medication: Ibuprofen	0.3	0.3	0.9	-0.9	0.5	1.0	0.1	0.3	-0.5	-0.5	-0.0	0.1	-0.9
Suffer from ‘nerves’	0.3	0.4	2.0	-0.4	0.3	-0.5	0.5	0.2	-0.4	-1.4	0.7	0.6	0.7
Ever had bowel cancer screening	0.3	0.3	0.9	0.9	0.1	0.0	-0.6	-0.7	0.5	0.1	-1.0	-0.4	-0.3
Eye problems/disorders: Cataract	0.3	0.3	1.5	0.5	0.2	0.6	-0.4	0.9	1.2	0.3	0.0	0.1	0.0
Osteoarthritis (self-reported)	0.3	0.4	3.0	-1.7	0.2	0.8	0.6	0.3	-0.3	-0.2	-0.0	-0.3	-0.3
Arm fat mass (left)	0.3	1.2	5.6	-2.4	-1.0	0.7	0.7	-1.7	0.3	-1.2	-0.1	0.3	-0.5
Wears glasses or contact lenses	0.3	0.4	1.4	0.7	0.5	-0.5	1.2	0.6	-0.6	-0.8	-0.0	-0.2	0.4
Alzheimer’s Disease (including proxy)	0.2	0.4	0.9	-0.4	-0.8	0.8	0.5	-0.3	-0.2	-0.1	0.8	0.6	1.0
Reaction Time	0.2	0.4	1.7	0.1	0.1	0.7	-0.0	0.3	-0.5	-1.1	-0.6	1.3	-0.0
Blood Red Count	0.2	2.2	5.6	1.6	2.0	2.4	-0.4	-0.0	-1.2	-1.1	-1.6	-0.5	-2.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	0.2	0.4	1.0	-0.1	-0.1	-0.1	0.5	0.2	1.1	0.5
Alcohol usually taken with meals	0.2	0.4	1.0	0.7	-0.9	0.3	-0.4	0.8	-0.1	1.0	-0.1	0.8	0.3
Hearing difficulty/problems with background noise	0.2	0.4	2.4	0.2	-0.5	-1.5	-0.5	-0.5	0.4	0.0	-0.2	-0.5	-0.4
Financial difficulties in last 2 years	0.2	0.3	1.1	-0.6	0.2	0.9	0.3	-0.7	0.3	-0.5	0.1	1.0	0.4
Neuroticism score	0.2	0.5	2.4	-0.5	0.3	-1.6	-0.6	-0.2	0.6	-0.3	-0.8	0.2	-0.7
Worrier / anxious feelings	0.2	0.3	1.0	0.4	1.0	-0.7	-0.2	0.8	-0.2	-0.7	-0.6	0.1	-0.1
Tense / ‘highly strung’	0.2	0.3	0.9	-0.1	-0.6	-1.0	0.0	-0.4	0.2	0.0	0.4	0.9	1.0
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	0.7	0.7	1.1	-0.1	1.3	-0.6	1.1	0.1	0.3	0.0
Eye problems/disorders: None of the above	0.2	0.3	1.9	-0.2	0.1	0.5	-0.0	-0.2	-1.4	0.4	0.3	0.5	-0.1
Migraine (self-reported)	0.2	0.2	1.0	-0.3	-0.1	-0.5	-0.1	-0.3	-0.5	-0.4	-0.6	1.0	-0.4
Medication: Seretide 50 evohaler	0.2	0.3	1.5	-1.2	0.0	-0.6	-0.1	0.0	-0.0	-0.3	0.7	-0.3	0.2
Mood swings	0.2	0.4	2.3	1.5	-0.5	0.1	0.4	-0.2	0.3	-0.4	-0.6	0.5	-0.3
Guilty feelings	0.2	0.3	1.0	0.1	-0.7	0.3	0.2	-1.0	-0.7	-0.2	-0.4	-0.4	-0.5
Illnesses of father: High blood pressure	0.2	0.3	1.6	0.4	-0.1	0.5	-0.4	-1.3	0.1	0.1	-0.1	0.5	0.1
Hair Pigment	0.1	3.0	8.8	-3.0	-1.5	1.4	2.3	-1.4	-1.8	-0.7	2.2	-0.4	0.9
Tanning	0.1	0.9	3.0	0.5	-0.9	-1.7	1.2	1.0	-1.3	0.1	0.7	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.3	-0.1	-0.7	-0.1	0.6	0.1	-0.6	0.0	-0.4	0.1
Mean time to correctly identify matches	0.1	0.3	0.7	-0.3	-0.0	0.6	0.3	0.1	-0.8	-0.8	-0.7	0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	0.3	-0.3	-0.7	0.2	0.7	0.2	0.3	-0.2	0.1	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

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Trait associations