Hub : Genes

MYH10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0220	0.00240	0.029	0.019	0.010	0.015	0.012	1.7e-04	0.0018	0.0190	0.0059	0.0120
2	YFS	Blood	0.0262	0.0098	0.00045	0.000	0.008	0.000	0.007	-0.001	3.9e-01	0.0011	0.4200	0.0023	0.9000
3	TCGA	Thyroid Carcinoma	0.1590	0.0610	0.00350	0.043	0.004	0.022	NA	0.019	4.8e-05	0.1300	0.0028	NA	0.0058

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.2	1.9	4.3	2.1	-0.8	-0.9
Bipolar Disorder or Schizophrenia	1.5	3.7	7.4	2.7	-1.2	1.5
Depressed Affect (Nagel 2018)	0.8	1.8	3.2	-0.3	1.4	1.8
Depression (Nagel 2018)	0.2	0.4	0.5	-0.5	0.6	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	1.2	-0.9	-0.2
Neuroticism (Nagel 2018)	0.8	1.9	4.6	-0.6	0.8	2.1
Schizophrenia (2018)	1.6	3.3	5.9	1.8	-0.9	2.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.8	-0.6	0.2
Worry (Nagel 2018)	0.6	1.3	1.4	-1.2	1.1	1.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	-0.2	0.0
Alzheimer’s Disease (in father)	0.7	0.8	2.0	1.4	0.0	-0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	0.7	0.4	-0.4
Crohns Disease (2017)	0.4	0.9	1.1	-0.8	1.0	-1.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.2	0.7	-0.5
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.6	-0.3	0.0
Major Depression (MDD)	1.5	1.9	4.0	-1.0	2.0	-0.7
Reaction Time	0.1	0.2	0.6	-0.0	-0.8	0.1
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.0	2.2	-0.5	-1.3
Breast Cancer	0.4	1.0	2.0	-0.2	-0.9	1.4
Ovarian Cancer	1.1	1.4	4.0	-0.2	-0.5	2.0
Prostate Cancer	0.8	1.1	3.0	1.7	-0.6	-0.0
Age at First Birth	1.0	1.5	2.8	1.7	0.9	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	-0.4	-0.4	0.0
Coronary Artery Disease (CAD)	1.0	1.2	2.4	0.9	-1.6	0.5
Crohns Disease (2012)	0.3	0.4	0.7	0.9	-0.2	-0.7
Mean Putamen Volume	0.6	0.7	1.0	-1.0	0.8	0.6
Fasting Glucose	1.4	1.7	4.7	-0.6	2.2	0.2
HbA1C	1.3	1.4	4.2	2.0	0.1	-0.1
HDL Cholesterol	0.9	1.5	4.3	0.1	-2.1	-0.5
LDL Cholesterol	4.5	7.2	10.7	3.3	-2.7	1.8
Lupus	0.3	0.4	0.5	-0.7	-0.7	-0.6
Neuroticism (2016)	0.2	0.3	0.8	0.4	0.1	0.9
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.8	-0.3	0.0
Rheumatoid Arthritis	1.5	2.1	3.0	1.7	-0.7	-1.7
Schizophrenia (2014)	0.6	1.4	2.7	1.2	0.0	1.6
Triglycerides	0.3	0.6	0.9	0.3	0.9	0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.7	0.2	0.2
Ulcerative Colitis	0.1	0.1	0.3	0.5	-0.2	0.0
Blood Eosinophil Count	0.7	5.6	9.7	-2.7	3.1	-0.1
Blood Platelet Count	0.0	0.2	0.4	-0.4	-0.6	-0.0
Blood Red Count	1.3	12.8	30.8	2.2	-5.5	-1.6
Blood White Count	1.5	11.0	21.7	-4.7	3.4	-0.0
Heel T-Score	0.7	5.3	14.0	1.3	-3.7	-0.1
BMI	0.7	3.8	6.4	-2.5	-0.2	2.2
Height	0.2	2.9	5.5	2.4	1.0	1.5
Waist Hip Ratio (WHR)	1.3	5.7	13.5	1.8	-3.7	-0.5
Systolic Blood Pressure	1.1	5.3	9.6	-3.1	2.2	-1.1
Smoking Status	1.0	2.3	6.6	-2.6	0.5	0.1
Allergy or Eczema	0.5	1.3	3.3	-0.1	-0.7	-1.8
Cardiovascular Disease	0.9	2.9	6.0	-2.5	0.9	1.4
Hypothyroidism (self reported)	0.1	0.3	0.6	0.4	0.5	0.8
Respiratory disease	0.7	1.5	3.3	-1.0	-0.3	-1.8
Type 2 Diabetes (T2D) (2018)	0.9	1.8	2.3	-0.9	-1.5	1.5
Lung FEV1/FVC ratio	0.5	2.6	4.2	-1.7	0.8	2.0
Lung FVC	0.5	2.4	5.0	2.2	-1.5	-0.1
Neuroticism	1.2	2.9	5.7	-1.0	2.4	1.4
Chronotype (morning person)	0.2	0.4	0.7	0.7	-0.8	-0.4
Hair Pigment	0.0	0.1	0.1	0.3	-0.3	-0.3
Tanning	0.1	1.0	1.9	-1.4	-0.3	-1.0
Hand grip strength (left)	0.5	1.2	2.7	1.6	0.7	-0.7
Number of treatments/medications taken	0.5	0.9	2.6	-1.6	0.0	0.1
Average weekly spirits intake	0.2	0.2	0.4	-0.4	-0.3	0.6
Sensitivity / hurt feelings	0.5	0.9	1.4	-1.0	0.5	1.2
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.1	-1.4	1.4	0.8
Hearing difficulty/problems: Yes	1.5	2.3	5.8	-0.0	2.4	1.0
Relative age of first facial hair	0.8	1.5	4.4	2.1	0.3	-0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	-0.2	-0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.2	2.4	-1.5	0.5	-1.0
Ever had hysterectomy (womb removed)	1.6	1.8	4.7	-0.1	0.8	-2.2
Systolic blood pressure, automated reading	1.1	3.1	5.3	-1.5	2.3	-1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.6	-0.5	-1.6	0.4
Angina	0.2	0.3	0.8	-0.9	0.1	0.0
Medication for hormone replacement therapy	1.1	1.2	2.3	-1.5	0.4	-1.1
Vitamin and mineral supplements	1.8	2.4	3.8	1.3	-1.4	-2.0
Supplements: Zinc	2.2	2.4	5.4	-1.4	2.3	-0.2
Medication: Co-codamol	0.3	0.3	0.7	0.4	0.2	0.8
Medication: Metformin	2.7	3.9	8.4	-1.7	-2.9	-0.5
Diabetes (father)	0.2	0.2	0.4	-0.6	0.2	0.4
Diabetes (mother)	0.4	0.5	1.5	0.1	-0.2	1.2
Severe depression (siblings)	0.7	0.8	2.3	0.5	-1.5	-0.2
Pack years adult smoking proportion	2.9	4.5	7.8	-2.8	2.3	-0.6
Impedance of leg (right)	0.3	1.4	2.9	-0.1	-1.7	-1.1
Leg fat-free mass (left)	0.4	2.1	5.6	0.3	0.8	2.4
Trunk fat percentage	0.6	2.4	5.2	-0.2	-2.3	1.4
Hand grip strength (right)	0.3	0.8	1.7	1.3	-0.4	0.7
Townsend deprivation index at recruitment	0.7	1.0	1.6	-0.8	1.2	-1.0
Current tobacco smoking	2.3	3.8	8.8	-1.6	3.0	0.2
Average weekly fortified wine intake	0.2	0.2	0.5	0.7	0.4	0.1
Maternal smoking around birth	0.0	0.0	0.1	-0.1	0.3	-0.0
Fed-up feelings	0.5	1.0	1.7	-0.1	1.1	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.0	-0.5	1.4	1.3
Relative age voice broke	0.9	1.4	3.0	0.8	1.7	-0.8
Taking other prescription medications	0.7	1.0	2.6	-0.6	1.6	0.4
Age when periods started (menarche)	0.2	0.4	1.0	0.4	-0.4	1.0
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	8.3	-0.5	2.9	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.1	0.1	-2.0	-0.9
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.2	-1.6	2.0	-0.1
Qualifications: CSEs or equivalent	0.4	0.6	1.1	-0.1	-0.8	1.0
Serious illness, injury or assault to yourself	1.8	2.2	4.8	-1.1	2.2	0.8
High blood pressure	1.0	2.8	5.7	-2.4	1.6	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.6	-0.2	-0.3	-1.6
Multivitamins +/- minerals	0.8	1.0	1.2	-1.0	0.9	1.1
Stomach or abdominal pain in last month	0.6	0.8	1.5	-1.2	-0.5	0.8
Supplements: Glucosamine	0.5	0.6	1.2	-0.2	1.1	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	-0.1	0.3	-1.1
Medication: Atenolol	0.8	1.0	2.2	-0.5	1.5	-0.7
Medication: Levothyroxine sodium	0.7	1.2	1.9	1.4	0.5	1.2
Sitting height	0.3	2.5	6.0	0.1	1.2	2.5
Chronic bronchitis/emphysema (father)	2.6	3.0	6.9	1.2	-2.6	0.8
High blood pressure (mother)	1.0	1.3	3.3	-0.7	1.8	-0.5
Body mass index (BMI)	0.3	1.4	3.1	-0.3	-0.9	1.8
Impedance of leg (left)	0.4	1.7	3.0	0.6	-1.4	-1.7
Leg predicted mass (left)	0.4	2.2	5.7	0.3	0.9	2.4
Trunk fat mass	0.5	2.2	3.8	0.1	-1.6	2.0
Waist circumference	0.6	2.3	3.6	0.3	-1.9	1.8
Number of incorrect matches in round	2.1	3.6	5.0	-2.2	1.2	-2.1
Past tobacco smoking	1.1	2.1	5.4	2.3	0.3	-0.9
Alcohol usually taken with meals	0.3	0.5	0.9	-0.8	-0.2	0.9
Nervous feelings	0.8	1.5	2.8	-1.7	1.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.7	-1.6	1.6	0.6
Hearing difficulty/problems with background noise	1.0	1.5	2.1	0.9	1.3	1.5
Hair/balding pattern: Pattern 2	1.0	1.2	2.2	-1.5	-0.6	1.0
Had menopause	0.3	0.4	1.0	0.4	-1.0	0.3
Had other major operations	2.0	2.4	7.1	-2.7	-0.4	0.0
Forced vital capacity (FVC)	0.5	1.8	4.6	2.1	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.9	1.0	-2.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.3	-0.1	-0.6
Qualifications: None of the above	0.2	0.3	0.7	-0.8	-0.3	-0.4
Financial difficulties in last 2 years	2.3	3.1	9.0	-0.3	3.0	-0.4
Mouth/teeth dental problems	0.2	0.4	0.9	0.9	0.4	0.3
Heart attack	0.2	0.2	0.5	0.7	0.3	0.4
Allergy	0.4	1.0	3.0	0.2	-0.1	1.7
Pain all over the body in last month	0.3	0.3	0.7	0.0	0.4	0.8
Diabetes (self-reported)	1.1	1.7	2.7	-1.7	-1.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.5	-0.8	-1.2	-0.9
Medication: Ramipril	0.7	0.9	2.1	-0.7	-0.3	-1.5
Medication: Simvastatin	0.2	0.3	1.0	0.1	-1.0	0.0
Fluid intelligence score	0.7	1.4	2.2	1.5	1.5	0.1
Illnesses of siblings	0.2	0.3	0.5	0.5	-0.7	-0.4
Neuroticism score	0.8	1.7	3.8	0.0	2.0	1.1
Weight	0.5	2.4	6.8	0.6	-0.5	2.6
Impedance of arm (right)	0.2	0.9	2.3	-0.7	-0.1	-1.5
Arm fat percentage (right)	0.3	1.3	2.0	-0.6	-1.4	1.3
Trunk fat-free mass	0.5	3.0	5.7	0.5	1.7	2.4
Hip circumference	0.5	1.9	5.5	-0.5	0.3	2.3
Time employed in main current job	1.1	1.3	2.6	1.6	-1.1	-0.2
Alcohol intake versus 10 years previously	1.0	1.5	2.1	-0.6	1.4	-1.5
Father’s age at death	1.2	1.6	4.6	0.2	0.3	-2.1
Worrier / anxious feelings	0.9	1.7	4.8	-2.2	0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.1	0.7	0.6	1.0
Falls in the last year	0.4	0.5	1.4	-0.5	1.2	-0.2
Hair/balding pattern: Pattern 3	0.8	1.1	2.3	0.8	0.7	-1.5
Number of live births	0.7	1.0	1.4	-1.2	0.3	1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.9	1.4	-0.7	0.2
Pulse rate	0.3	0.5	0.9	0.8	0.2	0.9
Happiness	0.4	0.4	0.7	0.8	0.8	-0.1
Noisy workplace	1.5	1.9	5.0	-2.2	0.7	-0.0
Qualifications: A levels/AS levels or equivalent	1.2	2.5	4.9	2.2	-0.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.7	-0.3	0.7	-1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	2.6	-0.7	1.6	0.2
Asthma	0.4	0.8	1.2	-1.1	-0.3	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.5	-2.1	0.8	0.3
Medication: Cholesterol lowering	0.4	0.6	1.4	0.1	-0.6	-1.2
Depression (self-reported)	0.9	1.1	1.9	-1.1	0.0	1.4
Medication: Lansoprazole	0.1	0.1	0.2	0.4	-0.5	-0.1
Prospective memory result	0.6	0.7	1.5	-0.4	-1.2	-0.7
Lung cancer (father)	2.0	2.3	2.8	-1.3	-1.6	1.7
Illnesses of mother	0.0	0.0	0.0	-0.1	0.2	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.1	1.0	-0.7	0.7
Pulse wave Arterial Stiffness index	2.1	2.5	6.4	0.2	-1.0	2.5
Impedance of arm (left)	0.1	0.6	1.4	-0.4	-0.6	-1.2
Arm fat mass (right)	0.4	1.5	3.5	-0.1	-1.0	1.9
Trunk predicted mass	0.5	3.0	5.8	0.5	1.7	2.4
Standing height	0.2	2.3	3.0	1.7	1.0	1.7
Length of working week for main job	0.3	0.3	0.4	-0.7	-0.4	-0.5
Exposure to tobacco smoke at home	1.0	1.2	2.9	-0.6	0.4	-1.7
Breastfed as a baby	0.6	0.8	1.0	0.7	1.0	-0.9
Tense / ‘highly strung’	2.4	3.9	5.1	-2.3	1.9	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.7	0.9	0.3
Hair/balding pattern: Pattern 4	0.2	0.6	0.9	-0.6	0.9	0.7
Birth weight of first child	0.1	0.2	0.6	-0.8	-0.1	0.2
Peak expiratory flow (PEF)	0.3	0.7	1.8	0.3	-1.4	-0.0
Pulse wave reflection index	0.5	0.6	1.4	0.2	-0.5	1.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	1.2	-0.2	-1.0
Loud music exposure frequency	0.2	0.2	0.3	-0.6	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	4.7	2.1	-2.2	-0.0
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	5.7	-2.4	0.6	0.2
Blood clot in the leg (DVT)	0.8	1.1	1.8	-1.1	1.3	-0.4
Medication: Paracetamol	0.4	0.6	0.7	-0.9	0.8	-0.7
Headache pain in last month	0.3	0.5	0.8	-0.0	-0.8	-0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	0.0	-0.4	1.3
Glaucoma (self-reported)	3.3	3.8	9.4	-1.3	3.1	0.7
Gout (self-reported)	0.5	0.6	1.8	-1.3	-0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.9	0.1	0.6
Medication: Amlodipine	0.2	0.3	0.6	0.0	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.3	1.6	4.3	0.7	0.4	-2.1
Birth weight	0.8	1.7	5.0	0.2	2.2	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.3	-0.8	0.4
High blood pressure (siblings)	0.6	0.8	1.8	-1.3	0.7	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.5	3.7	1.9	-0.7	0.7
Body fat percentage	0.6	2.4	5.0	-0.3	-2.2	1.4
Leg fat percentage (right)	0.7	2.4	4.0	-0.4	-2.0	1.7
Arm fat-free mass (right)	0.4	2.2	5.5	0.9	0.3	2.3
Exposure to tobacco smoke outside home	1.3	1.7	2.9	1.7	-1.5	-0.2
Comparative body size at age 10	0.0	0.0	0.1	-0.3	0.1	-0.1
Number of full brothers	0.7	0.9	1.8	0.9	0.3	1.4
Worry too long after embarrassment	0.5	0.8	1.5	-0.5	0.7	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.3	0.7	0.0	1.1
Wheeze or whistling in the chest in last year	0.4	0.6	1.7	0.4	1.3	-0.2
Number of children fathered	1.1	1.2	3.5	-1.9	0.4	0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	1.6	-1.2	-1.3	0.8
Age at first live birth	1.1	1.9	2.7	1.5	-1.6	-0.8
Pulse wave peak to peak time	2.1	2.5	6.0	-0.1	1.2	-2.5
Health satisfaction	0.1	0.1	0.2	0.0	0.4	-0.5
Shortness of breath walking on level ground	1.1	1.3	1.9	1.4	-1.0	0.9
Qualifications: College or University degree	0.2	0.8	1.5	0.2	1.2	0.9
Eye problems/disorders: None of the above	0.9	1.1	1.7	-0.5	-1.1	-1.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.2	-0.5	0.3
Emphysema/chronic bronchitis	0.3	0.3	0.9	0.1	-0.1	0.9
Medication for pain relief, constipation, heartburn	1.0	1.7	4.3	2.1	-0.9	0.0
Neck or shoulder pain in last month	0.7	1.0	1.9	0.6	-0.9	1.4
Medication: Blood pressure	0.2	0.4	0.9	-0.4	0.2	-1.0
Angina (self-reported)	0.2	0.2	0.7	-0.8	-0.1	0.1
Migraine (self-reported)	0.3	0.4	0.6	-0.8	0.5	-0.6
Medication: Ibuprofen	0.5	0.6	1.9	-1.4	0.0	0.0
Medication: Allopurinol	0.0	0.1	0.1	0.4	-0.2	0.0
Medication: Omeprazole	1.0	1.1	1.9	-1.1	1.4	-0.5
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.0	-1.0	0.1
Mean time to correctly identify matches	0.1	0.2	0.4	0.4	-0.7	-0.4
Heart disease (mother)	0.9	1.1	3.2	1.8	-0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.9	-1.7	0.7	-1.6
Whole body fat mass	0.5	2.2	3.8	-0.1	-1.7	2.0
Leg fat mass (right)	0.5	2.1	3.8	-0.1	-1.6	1.9
Arm predicted mass (right)	0.6	2.9	7.1	1.2	0.3	2.7
Pulse rate, automated reading	0.7	2.2	3.5	1.7	-1.9	0.5
Alcohol intake frequency.	0.3	0.7	1.2	-1.1	0.8	-0.4
Comparative height size at age 10	0.8	4.1	7.2	-0.2	2.7	2.3
Number of full sisters	1.4	1.7	2.4	-1.5	1.5	-0.6
Suffer from ‘nerves’	0.8	1.2	1.9	-1.4	1.3	-0.3
Overall health rating	0.8	1.8	4.7	-0.8	2.2	-0.4
Chest pain or discomfort	0.3	0.4	0.6	-0.6	0.8	0.5
Had major operations	0.7	0.8	2.2	-0.6	-0.1	-1.5
Age at last live birth	0.5	0.7	1.6	0.7	-1.3	-0.1
Family relationship satisfaction	0.2	0.3	0.4	0.1	-0.7	-0.7
Leg pain on walking	0.0	0.0	0.1	0.2	-0.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.0	0.8	-0.0
Commuting to job workplace: Car/motor vehicle	2.3	2.6	4.6	-1.8	0.3	2.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.5	1.6	-1.4	-0.2
Medication: Aspirin	0.7	0.9	1.1	-1.0	0.9	1.0
Supplements: Vitamin C	0.3	0.4	1.0	-0.3	0.3	1.0
Knee pain experienced in last month	0.2	0.4	0.6	0.4	-0.8	0.6
Hypertension (Self-reported)	1.1	3.1	6.1	-2.5	1.8	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	0.3	0.5	0.9
Illnesses of father: Heart disease	1.9	2.6	5.5	2.4	-1.6	-0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.4	-0.6	0.2	-0.2
Smoking status: Previous	1.0	1.4	1.8	-1.2	-1.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.4	0.5	0.5
Whole body fat-free mass	0.5	2.7	5.9	0.5	1.4	2.4
Leg fat-free mass (right)	0.4	2.2	4.2	0.8	1.3	2.0
Arm fat percentage (left)	0.5	1.8	2.7	-0.5	-1.6	1.6
Average weekly red wine intake	0.5	0.7	1.4	-0.8	0.2	1.2
Handedness (chirality/laterality): Left-handed	2.2	2.7	7.6	-2.8	0.5	0.5
Mood swings	0.6	1.1	2.7	-0.7	1.6	-0.2
Loneliness, isolation	2.3	3.2	5.4	-0.6	2.3	1.9
Long-standing illness, disability or infirmity	0.2	0.4	0.7	0.2	0.6	0.8
Ever had bowel cancer screening	0.3	0.3	0.4	-0.6	0.6	0.6
Diabetes diagnosed by doctor	0.9	1.4	2.4	-0.7	-1.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.2	0.4	0.5
Friendships satisfaction	0.3	0.4	0.8	0.5	0.3	0.9
Qualifications: nursing, teaching	0.7	1.1	2.1	1.0	-1.4	0.5
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.3	-0.7	-0.9
Eye problems/disorders: Cataract	0.4	0.4	1.0	1.0	0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	-0.4	-1.4	0.5
Medication for cholesterol	1.1	1.6	3.6	1.9	-1.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	3.1	-1.8	-1.7	0.5
Back pain experienced in last month	1.2	1.7	3.5	1.3	-0.3	1.9
Mineral and other dietary supplements	1.0	1.4	2.9	1.1	-1.7	-0.1
Breast cancer (self-reported)	0.7	0.9	2.3	-1.5	-0.5	0.2
Asthma (self-reported)	0.5	0.9	1.6	-1.3	-0.1	-1.1
Osteoporosis (self-reported)	1.0	1.3	2.4	-1.1	-1.6	0.5
Osteoarthritis (self-reported)	0.5	0.7	1.5	-0.5	1.2	-0.4
Medication: Aspirin	0.5	0.6	1.1	-0.4	0.8	1.0
Medication: Gliclazide	1.7	1.9	4.7	-0.1	-2.2	-1.0
Illnesses of father: None of the above (group 1)	1.9	2.3	5.3	-0.5	2.3	1.1
Smoking status: Current	2.2	3.5	7.9	-1.6	2.8	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	-0.1	-1.1	-0.4
Whole body water mass	0.5	2.8	6.0	0.6	1.4	2.4
Leg predicted mass (right)	0.4	2.1	4.1	0.9	1.3	2.0
Arm fat mass (left)	0.5	1.9	4.6	0.0	-1.1	2.2
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	-1.2	0.1	-0.9
Average weekly champagne plus white wine intake	1.5	2.0	3.6	-1.9	0.2	1.6
Miserableness	2.0	3.4	7.2	-0.6	1.7	2.7
Guilty feelings	0.5	0.7	1.9	-0.4	0.2	1.4
Wears glasses or contact lenses	0.2	0.3	0.7	-0.1	-0.3	0.8
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.5	-0.5	0.1
Hearing aid user	0.4	0.5	1.4	-1.2	0.1	-0.2
Mother’s age at death	0.0	0.0	0.1	0.2	0.2	0.1
Financial situation satisfaction	0.3	0.4	1.1	0.0	0.1	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	-1.0	0.8	0.4
Commuting to job workplace: Public transport	1.7	2.0	4.2	1.1	2.1	-0.9
Eye problems/disorders: Glaucoma	2.8	3.3	7.0	-1.3	2.7	1.1
Medication: Blood pressure	1.4	2.7	6.0	-2.4	1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.6	0.9	0.4	0.8	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.6	-0.2	1.9	0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.3	0.1	0.5
Medication: Bendroflumethiazide	0.7	1.1	2.7	-0.4	1.7	0.7
Medication: Paracetamol	0.7	1.0	1.5	-1.0	1.2	-0.7
Medication: Lisinopril	1.0	1.4	2.8	-1.7	1.1	0.4
Medication: Atorvastatin	0.7	0.9	2.4	0.1	1.5	0.5
Illnesses of father: High blood pressure	2.8	3.4	7.2	-1.8	0.1	-2.7
Alcohol drinker status: Never	0.2	0.2	0.3	0.6	-0.4	0.4
Ever smoked	2.0	3.5	9.0	-3.0	1.1	0.4
Basal metabolic rate	0.5	2.6	6.6	0.5	0.9	2.6
Leg fat percentage (left)	0.5	1.7	3.3	-0.1	-1.8	1.4
Arm fat-free mass (left)	0.5	2.6	6.6	0.9	0.6	2.6
Number of operations (self-reported)	1.4	2.0	4.4	-2.1	0.1	-1.3
Average weekly beer plus cider intake	0.4	0.6	1.0	0.9	0.1	-1.0
Irritability	0.4	0.6	1.5	1.2	0.6	-0.2
Risk taking	0.4	0.6	0.9	0.9	-0.9	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.4	0.3	-0.0
Fractured/broken bones in last 5 years	0.3	0.3	0.9	0.2	-0.1	1.0
Age started oral contraceptive pill	1.7	2.2	3.4	1.9	-0.4	-1.7
Diastolic blood pressure, automated reading	1.2	3.7	7.7	-2.8	1.8	0.0
Ever depressed for a whole week	1.2	1.5	3.8	-0.5	1.9	-0.8
Unable to work because of sickness or disability	4.4	5.7	9.5	-3.1	2.8	0.0
Commuting to job workplace: Cycle	1.4	1.7	4.2	2.0	-0.6	-0.7
Myopia	0.1	0.1	0.4	-0.1	-0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.9	2.6	4.5	1.8	-2.1	0.2
Cholesterol lowering medication	0.6	0.8	2.2	0.0	0.6	1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	-0.8	1.0	-0.5
Pain experienced in last month	0.3	0.5	1.4	-0.4	0.3	-1.2
Supplements: Calcium	2.0	2.2	4.4	-0.3	-2.1	1.4
Basal cell carcinoma (self-reported)	1.5	1.8	3.0	-1.4	1.7	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.8	0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.9	-1.7	1.4	-0.2
Heart disease (siblings)	0.9	1.1	2.0	0.5	-1.0	1.4
Alcohol drinker status: Previous	1.9	2.2	3.3	-1.5	-1.0	-1.8
Pack years of smoking	2.4	3.5	6.3	-2.5	1.9	-0.8
Impedance of whole body	0.3	1.6	3.1	0.1	-1.3	-1.7
Leg fat mass (left)	0.4	1.7	3.0	0.1	-1.4	1.7
Arm predicted mass (left)	0.3	1.8	4.1	0.7	0.8	2.0