Hub : Genes

MYH10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0560 0.0220 0.00240 0.029 0.019 0.010 0.015 0.012 1.7e-04 0.0018 0.0190 0.0059 0.0120
2 YFS Blood 0.0262 0.0098 0.00045 0.000 0.008 0.000 0.007 -0.001 3.9e-01 0.0011 0.4200 0.0023 0.9000
3 TCGA Thyroid Carcinoma 0.1590 0.0610 0.00350 0.043 0.004 0.022 NA 0.019 4.8e-05 0.1300 0.0028 NA 0.0058

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.2 1.9 4.3 2.1 -0.8 -0.9
Bipolar Disorder or Schizophrenia 1.5 3.7 7.4 2.7 -1.2 1.5
Depressed Affect (Nagel 2018) 0.8 1.8 3.2 -0.3 1.4 1.8
Depression (Nagel 2018) 0.2 0.4 0.5 -0.5 0.6 0.7
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 1.2 -0.9 -0.2
Neuroticism (Nagel 2018) 0.8 1.9 4.6 -0.6 0.8 2.1
Schizophrenia (2018) 1.6 3.3 5.9 1.8 -0.9 2.4
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 -0.8 -0.6 0.2
Worry (Nagel 2018) 0.6 1.3 1.4 -1.2 1.1 1.2
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 -0.1 -0.2 0.0
Alzheimer’s Disease (in father) 0.7 0.8 2.0 1.4 0.0 -0.6
Alzheimer’s Disease (including proxy) 0.2 0.3 0.4 0.7 0.4 -0.4
Crohns Disease (2017) 0.4 0.9 1.1 -0.8 1.0 -1.1
Irritable Bowel Disease (IBD) 0.1 0.3 0.5 0.2 0.7 -0.5
Ulcerative Colitis (UC) 0.1 0.2 0.4 0.6 -0.3 0.0
Major Depression (MDD) 1.5 1.9 4.0 -1.0 2.0 -0.7
Reaction Time 0.1 0.2 0.6 -0.0 -0.8 0.1
Verbal and Numeric Reasoning (VNR) 1.0 2.3 5.0 2.2 -0.5 -1.3
Breast Cancer 0.4 1.0 2.0 -0.2 -0.9 1.4
Ovarian Cancer 1.1 1.4 4.0 -0.2 -0.5 2.0
Prostate Cancer 0.8 1.1 3.0 1.7 -0.6 -0.0
Age at First Birth 1.0 1.5 2.8 1.7 0.9 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 -0.4 -0.4 0.0
Coronary Artery Disease (CAD) 1.0 1.2 2.4 0.9 -1.6 0.5
Crohns Disease (2012) 0.3 0.4 0.7 0.9 -0.2 -0.7
Mean Putamen Volume 0.6 0.7 1.0 -1.0 0.8 0.6
Fasting Glucose 1.4 1.7 4.7 -0.6 2.2 0.2
HbA1C 1.3 1.4 4.2 2.0 0.1 -0.1
HDL Cholesterol 0.9 1.5 4.3 0.1 -2.1 -0.5
LDL Cholesterol 4.5 7.2 10.7 3.3 -2.7 1.8
Lupus 0.3 0.4 0.5 -0.7 -0.7 -0.6
Neuroticism (2016) 0.2 0.3 0.8 0.4 0.1 0.9
Primary Biliary Cirrhosis 0.2 0.2 0.6 0.8 -0.3 0.0
Rheumatoid Arthritis 1.5 2.1 3.0 1.7 -0.7 -1.7
Schizophrenia (2014) 0.6 1.4 2.7 1.2 0.0 1.6
Triglycerides 0.3 0.6 0.9 0.3 0.9 0.9
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.5 -0.7 0.2 0.2
Ulcerative Colitis 0.1 0.1 0.3 0.5 -0.2 0.0
Blood Eosinophil Count 0.7 5.6 9.7 -2.7 3.1 -0.1
Blood Platelet Count 0.0 0.2 0.4 -0.4 -0.6 -0.0
Blood Red Count 1.3 12.8 30.8 2.2 -5.5 -1.6
Blood White Count 1.5 11.0 21.7 -4.7 3.4 -0.0
Heel T-Score 0.7 5.3 14.0 1.3 -3.7 -0.1
BMI 0.7 3.8 6.4 -2.5 -0.2 2.2
Height 0.2 2.9 5.5 2.4 1.0 1.5
Waist Hip Ratio (WHR) 1.3 5.7 13.5 1.8 -3.7 -0.5
Systolic Blood Pressure 1.1 5.3 9.6 -3.1 2.2 -1.1
Smoking Status 1.0 2.3 6.6 -2.6 0.5 0.1
Allergy or Eczema 0.5 1.3 3.3 -0.1 -0.7 -1.8
Cardiovascular Disease 0.9 2.9 6.0 -2.5 0.9 1.4
Hypothyroidism (self reported) 0.1 0.3 0.6 0.4 0.5 0.8
Respiratory disease 0.7 1.5 3.3 -1.0 -0.3 -1.8
Type 2 Diabetes (T2D) (2018) 0.9 1.8 2.3 -0.9 -1.5 1.5
Lung FEV1/FVC ratio 0.5 2.6 4.2 -1.7 0.8 2.0
Lung FVC 0.5 2.4 5.0 2.2 -1.5 -0.1
Neuroticism 1.2 2.9 5.7 -1.0 2.4 1.4
Chronotype (morning person) 0.2 0.4 0.7 0.7 -0.8 -0.4
Hair Pigment 0.0 0.1 0.1 0.3 -0.3 -0.3
Tanning 0.1 1.0 1.9 -1.4 -0.3 -1.0
Hand grip strength (left) 0.5 1.2 2.7 1.6 0.7 -0.7
Number of treatments/medications taken 0.5 0.9 2.6 -1.6 0.0 0.1
Average weekly spirits intake 0.2 0.2 0.4 -0.4 -0.3 0.6
Sensitivity / hurt feelings 0.5 0.9 1.4 -1.0 0.5 1.2
Frequency of depressed mood in last 2 weeks 1.1 1.5 2.1 -1.4 1.4 0.8
Hearing difficulty/problems: Yes 1.5 2.3 5.8 -0.0 2.4 1.0
Relative age of first facial hair 0.8 1.5 4.4 2.1 0.3 -0.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.4 -0.2 -0.2
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.4 -1.5 0.5 -1.0
Ever had hysterectomy (womb removed) 1.6 1.8 4.7 -0.1 0.8 -2.2
Systolic blood pressure, automated reading 1.1 3.1 5.3 -1.5 2.3 -1.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.6 -0.5 -1.6 0.4
Angina 0.2 0.3 0.8 -0.9 0.1 0.0
Medication for hormone replacement therapy 1.1 1.2 2.3 -1.5 0.4 -1.1
Vitamin and mineral supplements 1.8 2.4 3.8 1.3 -1.4 -2.0
Supplements: Zinc 2.2 2.4 5.4 -1.4 2.3 -0.2
Medication: Co-codamol 0.3 0.3 0.7 0.4 0.2 0.8
Medication: Metformin 2.7 3.9 8.4 -1.7 -2.9 -0.5
Diabetes (father) 0.2 0.2 0.4 -0.6 0.2 0.4
Diabetes (mother) 0.4 0.5 1.5 0.1 -0.2 1.2
Severe depression (siblings) 0.7 0.8 2.3 0.5 -1.5 -0.2
Pack years adult smoking proportion 2.9 4.5 7.8 -2.8 2.3 -0.6
Impedance of leg (right) 0.3 1.4 2.9 -0.1 -1.7 -1.1
Leg fat-free mass (left) 0.4 2.1 5.6 0.3 0.8 2.4
Trunk fat percentage 0.6 2.4 5.2 -0.2 -2.3 1.4
Hand grip strength (right) 0.3 0.8 1.7 1.3 -0.4 0.7
Townsend deprivation index at recruitment 0.7 1.0 1.6 -0.8 1.2 -1.0
Current tobacco smoking 2.3 3.8 8.8 -1.6 3.0 0.2
Average weekly fortified wine intake 0.2 0.2 0.5 0.7 0.4 0.1
Maternal smoking around birth 0.0 0.0 0.1 -0.1 0.3 -0.0
Fed-up feelings 0.5 1.0 1.7 -0.1 1.1 1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.0 -0.5 1.4 1.3
Relative age voice broke 0.9 1.4 3.0 0.8 1.7 -0.8
Taking other prescription medications 0.7 1.0 2.6 -0.6 1.6 0.4
Age when periods started (menarche) 0.2 0.4 1.0 0.4 -0.4 1.0
Bilateral oophorectomy (both ovaries removed) 2.6 3.0 8.3 -0.5 2.9 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 4.1 0.1 -2.0 -0.9
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 4.2 -1.6 2.0 -0.1
Qualifications: CSEs or equivalent 0.4 0.6 1.1 -0.1 -0.8 1.0
Serious illness, injury or assault to yourself 1.8 2.2 4.8 -1.1 2.2 0.8
High blood pressure 1.0 2.8 5.7 -2.4 1.6 -0.2
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.6 -0.2 -0.3 -1.6
Multivitamins +/- minerals 0.8 1.0 1.2 -1.0 0.9 1.1
Stomach or abdominal pain in last month 0.6 0.8 1.5 -1.2 -0.5 0.8
Supplements: Glucosamine 0.5 0.6 1.2 -0.2 1.1 0.8
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.2 -0.1 0.3 -1.1
Medication: Atenolol 0.8 1.0 2.2 -0.5 1.5 -0.7
Medication: Levothyroxine sodium 0.7 1.2 1.9 1.4 0.5 1.2
Sitting height 0.3 2.5 6.0 0.1 1.2 2.5
Chronic bronchitis/emphysema (father) 2.6 3.0 6.9 1.2 -2.6 0.8
High blood pressure (mother) 1.0 1.3 3.3 -0.7 1.8 -0.5
Body mass index (BMI) 0.3 1.4 3.1 -0.3 -0.9 1.8
Impedance of leg (left) 0.4 1.7 3.0 0.6 -1.4 -1.7
Leg predicted mass (left) 0.4 2.2 5.7 0.3 0.9 2.4
Trunk fat mass 0.5 2.2 3.8 0.1 -1.6 2.0
Waist circumference 0.6 2.3 3.6 0.3 -1.9 1.8
Number of incorrect matches in round 2.1 3.6 5.0 -2.2 1.2 -2.1
Past tobacco smoking 1.1 2.1 5.4 2.3 0.3 -0.9
Alcohol usually taken with meals 0.3 0.5 0.9 -0.8 -0.2 0.9
Nervous feelings 0.8 1.5 2.8 -1.7 1.2 0.5
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 2.7 -1.6 1.6 0.6
Hearing difficulty/problems with background noise 1.0 1.5 2.1 0.9 1.3 1.5
Hair/balding pattern: Pattern 2 1.0 1.2 2.2 -1.5 -0.6 1.0
Had menopause 0.3 0.4 1.0 0.4 -1.0 0.3
Had other major operations 2.0 2.4 7.1 -2.7 -0.4 0.0
Forced vital capacity (FVC) 0.5 1.8 4.6 2.1 -0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 4.9 1.0 -2.2 0.6
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.4 -0.3 -0.1 -0.6
Qualifications: None of the above 0.2 0.3 0.7 -0.8 -0.3 -0.4
Financial difficulties in last 2 years 2.3 3.1 9.0 -0.3 3.0 -0.4
Mouth/teeth dental problems 0.2 0.4 0.9 0.9 0.4 0.3
Heart attack 0.2 0.2 0.5 0.7 0.3 0.4
Allergy 0.4 1.0 3.0 0.2 -0.1 1.7
Pain all over the body in last month 0.3 0.3 0.7 0.0 0.4 0.8
Diabetes (self-reported) 1.1 1.7 2.7 -1.7 -1.4 0.6
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.5 -0.8 -1.2 -0.9
Medication: Ramipril 0.7 0.9 2.1 -0.7 -0.3 -1.5
Medication: Simvastatin 0.2 0.3 1.0 0.1 -1.0 0.0
Fluid intelligence score 0.7 1.4 2.2 1.5 1.5 0.1
Illnesses of siblings 0.2 0.3 0.5 0.5 -0.7 -0.4
Neuroticism score 0.8 1.7 3.8 0.0 2.0 1.1
Weight 0.5 2.4 6.8 0.6 -0.5 2.6
Impedance of arm (right) 0.2 0.9 2.3 -0.7 -0.1 -1.5
Arm fat percentage (right) 0.3 1.3 2.0 -0.6 -1.4 1.3
Trunk fat-free mass 0.5 3.0 5.7 0.5 1.7 2.4
Hip circumference 0.5 1.9 5.5 -0.5 0.3 2.3
Time employed in main current job 1.1 1.3 2.6 1.6 -1.1 -0.2
Alcohol intake versus 10 years previously 1.0 1.5 2.1 -0.6 1.4 -1.5
Father’s age at death 1.2 1.6 4.6 0.2 0.3 -2.1
Worrier / anxious feelings 0.9 1.7 4.8 -2.2 0.2 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.1 0.7 0.6 1.0
Falls in the last year 0.4 0.5 1.4 -0.5 1.2 -0.2
Hair/balding pattern: Pattern 3 0.8 1.1 2.3 0.8 0.7 -1.5
Number of live births 0.7 1.0 1.4 -1.2 0.3 1.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.9 1.4 -0.7 0.2
Pulse rate 0.3 0.5 0.9 0.8 0.2 0.9
Happiness 0.4 0.4 0.7 0.8 0.8 -0.1
Noisy workplace 1.5 1.9 5.0 -2.2 0.7 -0.0
Qualifications: A levels/AS levels or equivalent 1.2 2.5 4.9 2.2 -0.3 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.7 -0.3 0.7 -1.3
Mouth/teeth dental problems: Dentures 0.6 1.0 2.6 -0.7 1.6 0.2
Asthma 0.4 0.8 1.2 -1.1 -0.3 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.5 -2.1 0.8 0.3
Medication: Cholesterol lowering 0.4 0.6 1.4 0.1 -0.6 -1.2
Depression (self-reported) 0.9 1.1 1.9 -1.1 0.0 1.4
Medication: Lansoprazole 0.1 0.1 0.2 0.4 -0.5 -0.1
Prospective memory result 0.6 0.7 1.5 -0.4 -1.2 -0.7
Lung cancer (father) 2.0 2.3 2.8 -1.3 -1.6 1.7
Illnesses of mother 0.0 0.0 0.0 -0.1 0.2 0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.1 1.0 -0.7 0.7
Pulse wave Arterial Stiffness index 2.1 2.5 6.4 0.2 -1.0 2.5
Impedance of arm (left) 0.1 0.6 1.4 -0.4 -0.6 -1.2
Arm fat mass (right) 0.4 1.5 3.5 -0.1 -1.0 1.9
Trunk predicted mass 0.5 3.0 5.8 0.5 1.7 2.4
Standing height 0.2 2.3 3.0 1.7 1.0 1.7
Length of working week for main job 0.3 0.3 0.4 -0.7 -0.4 -0.5
Exposure to tobacco smoke at home 1.0 1.2 2.9 -0.6 0.4 -1.7
Breastfed as a baby 0.6 0.8 1.0 0.7 1.0 -0.9
Tense / ‘highly strung’ 2.4 3.9 5.1 -2.3 1.9 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.7 0.9 0.3
Hair/balding pattern: Pattern 4 0.2 0.6 0.9 -0.6 0.9 0.7
Birth weight of first child 0.1 0.2 0.6 -0.8 -0.1 0.2
Peak expiratory flow (PEF) 0.3 0.7 1.8 0.3 -1.4 -0.0
Pulse wave reflection index 0.5 0.6 1.4 0.2 -0.5 1.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.5 1.2 -0.2 -1.0
Loud music exposure frequency 0.2 0.2 0.3 -0.6 0.3 0.3
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 4.7 2.1 -2.2 -0.0
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 5.7 -2.4 0.6 0.2
Blood clot in the leg (DVT) 0.8 1.1 1.8 -1.1 1.3 -0.4
Medication: Paracetamol 0.4 0.6 0.7 -0.9 0.8 -0.7
Headache pain in last month 0.3 0.5 0.8 -0.0 -0.8 -0.9
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.7 0.0 -0.4 1.3
Glaucoma (self-reported) 3.3 3.8 9.4 -1.3 3.1 0.7
Gout (self-reported) 0.5 0.6 1.8 -1.3 -0.4 -0.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 0.9 0.1 0.6
Medication: Amlodipine 0.2 0.3 0.6 0.0 -0.8 -0.5
Medication: Ventolin 100micrograms inhaler 1.3 1.6 4.3 0.7 0.4 -2.1
Birth weight 0.8 1.7 5.0 0.2 2.2 0.1
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 0.3 -0.8 0.4
High blood pressure (siblings) 0.6 0.8 1.8 -1.3 0.7 -0.5
Forced vital capacity (FVC), Best measure 0.4 1.5 3.7 1.9 -0.7 0.7
Body fat percentage 0.6 2.4 5.0 -0.3 -2.2 1.4
Leg fat percentage (right) 0.7 2.4 4.0 -0.4 -2.0 1.7
Arm fat-free mass (right) 0.4 2.2 5.5 0.9 0.3 2.3
Exposure to tobacco smoke outside home 1.3 1.7 2.9 1.7 -1.5 -0.2
Comparative body size at age 10 0.0 0.0 0.1 -0.3 0.1 -0.1
Number of full brothers 0.7 0.9 1.8 0.9 0.3 1.4
Worry too long after embarrassment 0.5 0.8 1.5 -0.5 0.7 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.3 0.7 0.0 1.1
Wheeze or whistling in the chest in last year 0.4 0.6 1.7 0.4 1.3 -0.2
Number of children fathered 1.1 1.2 3.5 -1.9 0.4 0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 1.6 -1.2 -1.3 0.8
Age at first live birth 1.1 1.9 2.7 1.5 -1.6 -0.8
Pulse wave peak to peak time 2.1 2.5 6.0 -0.1 1.2 -2.5
Health satisfaction 0.1 0.1 0.2 0.0 0.4 -0.5
Shortness of breath walking on level ground 1.1 1.3 1.9 1.4 -1.0 0.9
Qualifications: College or University degree 0.2 0.8 1.5 0.2 1.2 0.9
Eye problems/disorders: None of the above 0.9 1.1 1.7 -0.5 -1.1 -1.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.2 -0.5 0.3
Emphysema/chronic bronchitis 0.3 0.3 0.9 0.1 -0.1 0.9
Medication for pain relief, constipation, heartburn 1.0 1.7 4.3 2.1 -0.9 0.0
Neck or shoulder pain in last month 0.7 1.0 1.9 0.6 -0.9 1.4
Medication: Blood pressure 0.2 0.4 0.9 -0.4 0.2 -1.0
Angina (self-reported) 0.2 0.2 0.7 -0.8 -0.1 0.1
Migraine (self-reported) 0.3 0.4 0.6 -0.8 0.5 -0.6
Medication: Ibuprofen 0.5 0.6 1.9 -1.4 0.0 0.0
Medication: Allopurinol 0.0 0.1 0.1 0.4 -0.2 0.0
Medication: Omeprazole 1.0 1.1 1.9 -1.1 1.4 -0.5
Medication: Seretide 50 evohaler 0.3 0.3 0.9 -0.0 -1.0 0.1
Mean time to correctly identify matches 0.1 0.2 0.4 0.4 -0.7 -0.4
Heart disease (mother) 0.9 1.1 3.2 1.8 -0.4 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 2.9 -1.7 0.7 -1.6
Whole body fat mass 0.5 2.2 3.8 -0.1 -1.7 2.0
Leg fat mass (right) 0.5 2.1 3.8 -0.1 -1.6 1.9
Arm predicted mass (right) 0.6 2.9 7.1 1.2 0.3 2.7
Pulse rate, automated reading 0.7 2.2 3.5 1.7 -1.9 0.5
Alcohol intake frequency. 0.3 0.7 1.2 -1.1 0.8 -0.4
Comparative height size at age 10 0.8 4.1 7.2 -0.2 2.7 2.3
Number of full sisters 1.4 1.7 2.4 -1.5 1.5 -0.6
Suffer from ‘nerves’ 0.8 1.2 1.9 -1.4 1.3 -0.3
Overall health rating 0.8 1.8 4.7 -0.8 2.2 -0.4
Chest pain or discomfort 0.3 0.4 0.6 -0.6 0.8 0.5
Had major operations 0.7 0.8 2.2 -0.6 -0.1 -1.5
Age at last live birth 0.5 0.7 1.6 0.7 -1.3 -0.1
Family relationship satisfaction 0.2 0.3 0.4 0.1 -0.7 -0.7
Leg pain on walking 0.0 0.0 0.1 0.2 -0.1 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.7 0.0 0.8 -0.0
Commuting to job workplace: Car/motor vehicle 2.3 2.6 4.6 -1.8 0.3 2.2
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.5 1.6 -1.4 -0.2
Medication: Aspirin 0.7 0.9 1.1 -1.0 0.9 1.0
Supplements: Vitamin C 0.3 0.4 1.0 -0.3 0.3 1.0
Knee pain experienced in last month 0.2 0.4 0.6 0.4 -0.8 0.6
Hypertension (Self-reported) 1.1 3.1 6.1 -2.5 1.8 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.8 0.3 0.5 0.9
Illnesses of father: Heart disease 1.9 2.6 5.5 2.4 -1.6 -0.1
Illnesses of siblings: Diabetes 0.1 0.2 0.4 -0.6 0.2 -0.2
Smoking status: Previous 1.0 1.4 1.8 -1.2 -1.4 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.3 0.4 0.5 0.5
Whole body fat-free mass 0.5 2.7 5.9 0.5 1.4 2.4
Leg fat-free mass (right) 0.4 2.2 4.2 0.8 1.3 2.0
Arm fat percentage (left) 0.5 1.8 2.7 -0.5 -1.6 1.6
Average weekly red wine intake 0.5 0.7 1.4 -0.8 0.2 1.2
Handedness (chirality/laterality): Left-handed 2.2 2.7 7.6 -2.8 0.5 0.5
Mood swings 0.6 1.1 2.7 -0.7 1.6 -0.2
Loneliness, isolation 2.3 3.2 5.4 -0.6 2.3 1.9
Long-standing illness, disability or infirmity 0.2 0.4 0.7 0.2 0.6 0.8
Ever had bowel cancer screening 0.3 0.3 0.4 -0.6 0.6 0.6
Diabetes diagnosed by doctor 0.9 1.4 2.4 -0.7 -1.6 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.2 0.4 0.5
Friendships satisfaction 0.3 0.4 0.8 0.5 0.3 0.9
Qualifications: nursing, teaching 0.7 1.1 2.1 1.0 -1.4 0.5
Commuting to job workplace: Walk 0.4 0.4 0.8 -0.3 -0.7 -0.9
Eye problems/disorders: Cataract 0.4 0.4 1.0 1.0 0.2 0.6
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.9 -0.4 -1.4 0.5
Medication for cholesterol 1.1 1.6 3.6 1.9 -1.1 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 3.1 -1.8 -1.7 0.5
Back pain experienced in last month 1.2 1.7 3.5 1.3 -0.3 1.9
Mineral and other dietary supplements 1.0 1.4 2.9 1.1 -1.7 -0.1
Breast cancer (self-reported) 0.7 0.9 2.3 -1.5 -0.5 0.2
Asthma (self-reported) 0.5 0.9 1.6 -1.3 -0.1 -1.1
Osteoporosis (self-reported) 1.0 1.3 2.4 -1.1 -1.6 0.5
Osteoarthritis (self-reported) 0.5 0.7 1.5 -0.5 1.2 -0.4
Medication: Aspirin 0.5 0.6 1.1 -0.4 0.8 1.0
Medication: Gliclazide 1.7 1.9 4.7 -0.1 -2.2 -1.0
Illnesses of father: None of the above (group 1) 1.9 2.3 5.3 -0.5 2.3 1.1
Smoking status: Current 2.2 3.5 7.9 -1.6 2.8 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 -0.1 -1.1 -0.4
Whole body water mass 0.5 2.8 6.0 0.6 1.4 2.4
Leg predicted mass (right) 0.4 2.1 4.1 0.9 1.3 2.0
Arm fat mass (left) 0.5 1.9 4.6 0.0 -1.1 2.2
Number of self-reported non-cancer illnesses 0.5 0.8 1.5 -1.2 0.1 -0.9
Average weekly champagne plus white wine intake 1.5 2.0 3.6 -1.9 0.2 1.6
Miserableness 2.0 3.4 7.2 -0.6 1.7 2.7
Guilty feelings 0.5 0.7 1.9 -0.4 0.2 1.4
Wears glasses or contact lenses 0.2 0.3 0.7 -0.1 -0.3 0.8
Ever taken oral contraceptive pill 0.2 0.2 0.3 0.5 -0.5 0.1
Hearing aid user 0.4 0.5 1.4 -1.2 0.1 -0.2
Mother’s age at death 0.0 0.0 0.1 0.2 0.2 0.1
Financial situation satisfaction 0.3 0.4 1.1 0.0 0.1 -1.0
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.0 -1.0 0.8 0.4
Commuting to job workplace: Public transport 1.7 2.0 4.2 1.1 2.1 -0.9
Eye problems/disorders: Glaucoma 2.8 3.3 7.0 -1.3 2.7 1.1
Medication: Blood pressure 1.4 2.7 6.0 -2.4 1.0 1.1
Pain type(s) experienced in last month: Hip pain 0.4 0.6 0.9 0.4 0.8 0.9
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.6 -0.2 1.9 0.5
High cholesterol (Self-reported) 0.1 0.1 0.2 -0.3 0.1 0.5
Medication: Bendroflumethiazide 0.7 1.1 2.7 -0.4 1.7 0.7
Medication: Paracetamol 0.7 1.0 1.5 -1.0 1.2 -0.7
Medication: Lisinopril 1.0 1.4 2.8 -1.7 1.1 0.4
Medication: Atorvastatin 0.7 0.9 2.4 0.1 1.5 0.5
Illnesses of father: High blood pressure 2.8 3.4 7.2 -1.8 0.1 -2.7
Alcohol drinker status: Never 0.2 0.2 0.3 0.6 -0.4 0.4
Ever smoked 2.0 3.5 9.0 -3.0 1.1 0.4
Basal metabolic rate 0.5 2.6 6.6 0.5 0.9 2.6
Leg fat percentage (left) 0.5 1.7 3.3 -0.1 -1.8 1.4
Arm fat-free mass (left) 0.5 2.6 6.6 0.9 0.6 2.6
Number of operations (self-reported) 1.4 2.0 4.4 -2.1 0.1 -1.3
Average weekly beer plus cider intake 0.4 0.6 1.0 0.9 0.1 -1.0
Irritability 0.4 0.6 1.5 1.2 0.6 -0.2
Risk taking 0.4 0.6 0.9 0.9 -0.9 -0.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.4 0.3 -0.0
Fractured/broken bones in last 5 years 0.3 0.3 0.9 0.2 -0.1 1.0
Age started oral contraceptive pill 1.7 2.2 3.4 1.9 -0.4 -1.7
Diastolic blood pressure, automated reading 1.2 3.7 7.7 -2.8 1.8 0.0
Ever depressed for a whole week 1.2 1.5 3.8 -0.5 1.9 -0.8
Unable to work because of sickness or disability 4.4 5.7 9.5 -3.1 2.8 0.0
Commuting to job workplace: Cycle 1.4 1.7 4.2 2.0 -0.6 -0.7
Myopia 0.1 0.1 0.4 -0.1 -0.7 -0.1
Vascular/heart problems diagnosed by doctor 0.9 2.6 4.5 1.8 -2.1 0.2
Cholesterol lowering medication 0.6 0.8 2.2 0.0 0.6 1.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.9 -0.8 1.0 -0.5
Pain experienced in last month 0.3 0.5 1.4 -0.4 0.3 -1.2
Supplements: Calcium 2.0 2.2 4.4 -0.3 -2.1 1.4
Basal cell carcinoma (self-reported) 1.5 1.8 3.0 -1.4 1.7 -0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 0.8 0.2 0.6
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 2.9 -1.7 1.4 -0.2
Heart disease (siblings) 0.9 1.1 2.0 0.5 -1.0 1.4
Alcohol drinker status: Previous 1.9 2.2 3.3 -1.5 -1.0 -1.8
Pack years of smoking 2.4 3.5 6.3 -2.5 1.9 -0.8
Impedance of whole body 0.3 1.6 3.1 0.1 -1.3 -1.7
Leg fat mass (left) 0.4 1.7 3.0 0.1 -1.4 1.7
Arm predicted mass (left) 0.3 1.8 4.1 0.7 0.8 2.0