Hub : Genes

SLC25A35

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0214	0.0097	1.0e-02	0.010	0.003	0.008	0.005	0.007	2.1e-04	3.6e-02	7.5e-04	0.0059	1.3e-03
2	TCGA	Breast Invasive Carcinoma	0.0293	0.0166	1.4e-03	0.005	0.014	0.006	NA	0.008	3.1e-02	5.6e-04	2.1e-02	NA	6.7e-03
3	TCGA	Lung Adenocarcinoma	0.0217	0.0127	6.1e-03	0.009	0.015	0.001	NA	0.013	2.9e-02	6.7e-03	2.2e-01	NA	1.0e-02
4	TCGA	Prostate Adenocarcinoma	0.0933	0.0317	7.5e-09	0.060	0.103	0.106	NA	0.105	6.9e-07	7.3e-11	3.9e-11	NA	4.5e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	2.0	3.5	-1.9	1.3	0.9	1.3
Bipolar Disorder or Schizophrenia	1.1	2.7	3.6	-1.0	1.9	1.9	1.6
Depressed Affect (Nagel 2018)	1.5	3.1	6.4	2.5	-0.7	-2.4	0.0
Depression (Nagel 2018)	0.8	1.2	3.8	1.9	0.6	-0.1	0.9
Intelligence (Savage-Jansen 2018)	1.6	4.8	10.4	0.4	-3.2	-0.7	-2.8
Neuroticism (Nagel 2018)	1.5	3.5	10.2	1.9	-0.5	-3.2	-0.1
Schizophrenia (2018)	0.7	1.4	2.6	0.2	1.4	1.6	1.0
Schizophrenia vs Biploar Disorder	0.3	0.5	1.1	1.0	0.3	-0.8	0.2
Worry (Nagel 2018)	0.8	1.7	5.6	0.3	0.8	-2.4	0.6
Alzheimer’s Disease (in mother)	1.3	1.5	2.3	-0.9	1.3	1.5	1.1
Alzheimer’s Disease (in father)	1.1	1.2	2.0	1.4	-1.1	-1.0	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.1	0.4	0.4	0.6
Crohns Disease (2017)	0.1	0.3	0.7	0.5	-0.3	-0.9	0.5
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.2	0.0	-0.3	0.6
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.5	0.4	0.3	0.4
Major Depression (MDD)	0.6	0.7	1.6	1.2	0.8	-0.7	0.2
Reaction Time	0.4	0.7	1.6	1.2	-0.0	-0.8	0.9
Verbal and Numeric Reasoning (VNR)	3.8	9.2	17.9	0.1	-4.1	-1.4	-4.2
Breast Cancer	0.5	1.2	3.2	1.8	-0.6	1.0	-0.6
Ovarian Cancer	0.3	0.4	1.3	1.1	-0.6	0.1	-0.2
Prostate Cancer	1.2	1.6	5.2	1.0	0.5	2.3	0.4
Age at First Birth	0.0	0.1	0.1	-0.3	-0.3	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	1.9	0.8	-0.5	-0.9	-1.4
Coronary Artery Disease (CAD)	1.4	1.7	2.5	-0.1	1.6	1.5	1.4
Crohns Disease (2012)	0.4	0.7	1.9	1.4	-0.7	-0.1	0.5
Mean Putamen Volume	2.0	2.3	4.1	1.2	-1.4	-2.0	-1.2
Fasting Glucose	1.7	2.1	6.0	0.5	-0.8	-2.4	-1.2
HbA1C	1.6	1.8	3.5	-1.5	0.9	1.9	0.7
HDL Cholesterol	0.6	0.9	2.2	0.3	-1.5	0.2	-1.2
LDL Cholesterol	2.8	4.4	15.4	-1.5	0.1	3.9	0.2
Lupus	0.7	1.1	1.5	-0.0	1.1	1.2	1.2
Neuroticism (2016)	0.5	0.7	1.1	-1.1	0.9	-0.3	0.8
Primary Biliary Cirrhosis	0.6	0.9	1.9	-0.5	1.4	1.1	0.6
Rheumatoid Arthritis	0.5	0.7	2.1	-0.2	0.6	1.5	0.6
Schizophrenia (2014)	0.0	0.1	0.4	0.0	0.6	0.1	0.2
Triglycerides	0.4	0.7	2.0	0.3	1.4	0.1	0.9
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.5	-0.3	1.9	0.8	1.5
Ulcerative Colitis	1.3	1.9	2.7	-1.7	1.4	1.0	1.3
Blood Eosinophil Count	1.6	12.6	20.3	2.6	-3.9	-4.5	-2.8
Blood Platelet Count	0.4	5.1	6.4	-2.5	2.5	1.9	2.0
Blood Red Count	3.9	37.2	84.6	-2.6	5.1	9.2	5.6
Blood White Count	1.0	7.3	18.5	2.2	1.1	-4.3	2.2
Heel T-Score	0.2	1.9	5.5	-0.9	0.6	2.3	1.0
BMI	0.3	1.8	3.3	0.4	1.0	-1.6	1.8
Height	2.2	42.3	82.4	1.4	-8.3	-4.1	-9.1
Waist Hip Ratio (WHR)	0.3	1.5	4.4	-1.1	-0.2	2.1	0.8
Systolic Blood Pressure	2.9	14.5	27.8	-1.2	5.3	2.2	4.9
Smoking Status	2.3	5.5	13.2	1.4	2.6	-0.2	3.6
Allergy or Eczema	1.3	3.4	6.5	-0.1	2.5	1.0	2.5
Cardiovascular Disease	1.4	4.8	8.2	-1.3	2.9	1.5	2.6
Hypothyroidism (self reported)	1.2	2.7	7.0	1.8	-0.6	-2.6	0.3
Respiratory disease	0.3	0.8	1.4	1.2	-1.0	-0.6	-0.3
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.3	0.3	0.3	0.1
Lung FEV1/FVC ratio	0.8	4.2	7.6	1.6	-1.8	-2.8	-1.8
Lung FVC	2.8	14.4	23.4	-2.8	3.9	4.8	3.3
Neuroticism	1.2	2.8	10.1	1.0	0.3	-3.2	0.2
Chronotype (morning person)	1.1	2.5	4.3	2.1	1.4	1.0	1.7
Hair Pigment	0.1	1.9	2.9	-0.2	1.4	1.6	1.7
Tanning	0.2	2.9	5.7	1.2	2.0	0.7	2.4
Hand grip strength (left)	0.2	0.4	0.9	0.8	-0.1	0.9	-0.4
Number of treatments/medications taken	3.4	6.2	11.2	-0.3	3.3	1.6	3.3
Average weekly spirits intake	0.6	0.7	1.7	-0.6	0.3	0.9	1.3
Sensitivity / hurt feelings	0.3	0.6	0.8	-0.1	0.9	-0.9	0.8
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.5	1.6	-0.1	-0.9	0.6
Hearing difficulty/problems: Yes	0.8	1.2	3.2	1.3	-0.1	-1.8	-0.2
Relative age of first facial hair	1.4	2.9	7.3	-0.1	-2.7	-0.9	-1.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	0.9	-0.0	-0.3	0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.5	1.1	1.2	0.3	1.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.2	0.1	0.0	-0.6
Systolic blood pressure, automated reading	0.8	2.3	5.0	-0.5	2.2	0.8	1.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.2	-0.7	-0.3	-0.5
Angina	0.6	0.8	1.6	-0.1	1.0	0.7	1.3
Medication for hormone replacement therapy	0.4	0.4	1.0	1.0	-0.1	-0.8	0.2
Vitamin and mineral supplements	1.3	1.7	6.0	-2.4	-0.0	-0.4	-0.8
Supplements: Zinc	0.7	0.7	1.4	0.0	1.1	0.5	1.2
Medication: Co-codamol	0.3	0.4	0.9	1.0	0.2	0.2	0.7
Medication: Metformin	0.5	0.7	1.3	-0.7	0.7	1.1	0.9
Diabetes (father)	2.2	2.7	4.8	-0.5	2.2	1.2	2.0
Diabetes (mother)	3.0	3.8	6.4	-1.3	1.8	2.0	2.5
Severe depression (siblings)	3.3	3.7	6.2	-2.5	1.7	1.8	1.6
Pack years adult smoking proportion	1.4	2.2	6.9	0.7	-1.2	-2.6	-0.2
Impedance of leg (right)	0.3	1.5	3.9	-1.3	-0.6	2.0	-0.5
Leg fat-free mass (left)	1.5	7.9	12.2	1.4	-2.8	-3.5	-3.0
Trunk fat percentage	0.2	0.6	1.0	0.5	-0.7	-1.0	-0.9
Hand grip strength (right)	0.3	0.7	1.4	1.0	-0.5	1.2	-0.5
Townsend deprivation index at recruitment	0.9	1.3	3.3	-0.4	1.2	0.6	1.8
Current tobacco smoking	1.2	2.0	5.1	2.2	0.6	-0.6	1.5
Average weekly fortified wine intake	0.9	1.1	3.5	-1.9	-0.5	-0.1	-0.8
Maternal smoking around birth	0.4	0.6	1.7	1.3	0.4	0.4	0.4
Fed-up feelings	1.3	2.4	4.4	2.1	-1.1	-2.0	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.5	1.9	-0.4	-0.4	0.5
Relative age voice broke	1.2	1.8	3.4	-0.2	-1.9	-0.9	-1.7
Taking other prescription medications	1.1	1.7	3.8	-0.2	1.6	-0.5	1.9
Age when periods started (menarche)	0.1	0.4	1.0	-0.0	-1.0	0.3	-0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	0.8	0.0	-1.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.8	-0.3	0.2	0.6	1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	-0.8	1.1	-0.1	1.3
Qualifications: CSEs or equivalent	6.0	7.9	11.7	-0.8	3.1	3.1	3.4
Serious illness, injury or assault to yourself	0.6	0.7	1.7	1.0	-0.5	-1.3	-0.0
High blood pressure	0.9	2.5	5.9	-0.8	2.4	0.4	1.8
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.1	0.1	2.0	1.0	2.0
Multivitamins +/- minerals	0.1	0.2	0.4	0.7	-0.2	0.4	0.3
Stomach or abdominal pain in last month	0.6	0.8	1.8	0.9	-0.5	-1.3	-0.3
Supplements: Glucosamine	0.4	0.5	1.4	0.3	0.6	0.0	1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-0.4	-0.9	-0.9	-0.4
Medication: Atenolol	0.5	0.6	1.5	-0.7	1.2	0.4	0.7
Medication: Levothyroxine sodium	1.0	1.6	3.6	1.9	-0.9	-1.5	0.1
Sitting height	2.0	14.1	25.1	0.0	-4.5	-3.3	-5.0
Chronic bronchitis/emphysema (father)	1.1	1.3	2.6	-0.3	0.4	1.6	1.6
High blood pressure (mother)	0.3	0.4	1.4	-0.1	-0.1	-1.2	-0.3
Body mass index (BMI)	0.1	0.5	1.7	-0.2	0.3	-1.3	0.3
Impedance of leg (left)	0.4	1.9	5.5	-1.4	-0.1	2.4	-0.3
Leg predicted mass (left)	1.5	7.9	12.5	1.3	-2.9	-3.5	-3.0
Trunk fat mass	0.6	2.4	3.4	0.7	-1.6	-1.8	-1.9
Waist circumference	0.1	0.5	1.7	-0.2	-0.3	-1.3	-0.5
Number of incorrect matches in round	3.5	5.8	8.5	-2.5	2.9	0.4	2.9
Past tobacco smoking	3.3	6.1	14.1	0.3	-3.2	-0.3	-3.8
Alcohol usually taken with meals	1.3	2.2	4.2	-1.6	2.0	0.8	1.1
Nervous feelings	0.9	1.7	3.0	-0.3	1.7	-1.2	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	6.4	0.9	-0.0	-2.5	-0.0
Hearing difficulty/problems with background noise	0.2	0.4	1.5	0.1	1.2	-0.1	0.1
Hair/balding pattern: Pattern 2	0.8	1.0	3.7	-0.0	0.3	-1.9	0.4
Had menopause	0.2	0.3	0.9	-0.2	0.4	0.9	-0.1
Had other major operations	2.3	2.8	3.8	1.9	-1.5	-1.9	-1.3
Forced vital capacity (FVC)	0.2	0.7	1.8	-0.6	-0.3	1.3	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.7	-0.4	0.5	1.0	1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	-0.1	1.3	0.7	0.3
Qualifications: None of the above	1.3	2.8	4.8	-0.8	2.0	1.3	2.2
Financial difficulties in last 2 years	0.4	0.5	1.0	-0.2	0.6	-1.0	0.8
Mouth/teeth dental problems	0.3	0.5	1.2	0.3	-0.8	0.3	-1.1
Heart attack	1.2	1.6	2.8	-0.3	1.2	1.7	1.3
Allergy	0.5	1.1	2.2	-0.8	-1.1	-0.5	-1.5
Pain all over the body in last month	1.3	1.3	3.5	-1.9	1.4	-0.1	0.3
Diabetes (self-reported)	0.1	0.1	0.2	-0.1	0.4	0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	-0.3	0.7	0.2	-0.1
Medication: Ramipril	0.7	0.9	1.7	-0.6	1.3	0.5	1.2
Medication: Simvastatin	1.7	2.5	4.1	-0.3	1.9	2.0	1.6
Fluid intelligence score	4.7	9.7	17.7	0.3	-4.2	-2.3	-4.0
Illnesses of siblings	0.4	0.6	1.4	0.3	-1.2	-0.5	-0.8
Neuroticism score	1.4	2.8	8.7	1.5	-0.5	-3.0	-0.4
Weight	1.0	4.9	7.2	0.3	-2.3	-2.6	-2.7
Impedance of arm (right)	0.6	2.6	3.9	2.0	-1.8	-0.8	-1.6
Arm fat percentage (right)	0.3	1.2	3.4	0.9	-0.6	-1.8	-0.5
Trunk fat-free mass	1.2	7.0	11.8	0.5	-2.7	-3.0	-3.4
Hip circumference	0.8	3.2	8.7	1.0	-1.0	-2.9	-1.5
Time employed in main current job	0.9	1.0	2.4	-1.6	0.4	1.2	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.1	-0.3	-0.7	0.3
Father’s age at death	1.0	1.4	2.3	1.4	-1.5	-0.9	-0.8
Worrier / anxious feelings	1.4	2.7	6.9	2.0	0.2	-2.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.1	1.0	1.0	0.4	2.0
Falls in the last year	0.9	1.2	3.6	-1.9	0.4	-1.0	0.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.7	-0.1	0.6	0.7
Number of live births	2.4	3.5	5.5	-1.7	2.3	-0.2	2.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	-0.4	-0.6	0.4	-0.8
Pulse rate	0.9	1.5	3.6	-0.6	-1.0	-0.9	-1.9
Happiness	0.7	0.8	1.5	0.3	-0.5	-1.2	-1.2
Noisy workplace	4.4	5.4	10.9	0.0	2.9	1.6	3.3
Qualifications: A levels/AS levels or equivalent	2.6	5.8	10.7	1.3	-3.0	-1.3	-3.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	0.4	-0.7	0.0	0.2
Mouth/teeth dental problems: Dentures	1.0	1.7	4.1	1.1	1.1	0.4	2.0
Asthma	0.1	0.1	0.4	0.1	-0.3	0.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	0.5	0.8	-0.5	1.0
Medication: Cholesterol lowering	2.3	3.7	5.1	-0.8	2.2	2.2	2.0
Depression (self-reported)	1.0	1.2	3.7	0.5	0.9	0.5	1.9
Medication: Lansoprazole	2.7	3.1	7.8	-2.8	1.4	1.2	1.0
Prospective memory result	2.6	3.2	5.5	-0.7	2.4	1.2	2.3
Lung cancer (father)	3.7	4.3	4.8	2.2	-2.2	-2.1	-1.8
Illnesses of mother	3.1	3.9	6.4	0.8	-2.5	-1.9	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.0	-1.4	0.1	0.4	-0.4
Pulse wave Arterial Stiffness index	2.2	2.5	3.6	-0.8	1.8	1.9	1.7
Impedance of arm (left)	0.7	3.2	5.0	2.2	-2.0	-0.7	-1.8
Arm fat mass (right)	0.5	2.1	4.6	0.5	-1.3	-2.1	-1.4
Trunk predicted mass	1.3	7.5	12.5	0.6	-2.8	-3.0	-3.5
Standing height	2.1	20.8	41.1	1.1	-5.5	-3.2	-6.4
Length of working week for main job	0.3	0.3	1.0	0.3	-1.0	0.0	-0.1
Exposure to tobacco smoke at home	1.5	1.6	2.5	-1.6	0.8	1.2	1.3
Breastfed as a baby	0.1	0.2	0.4	-0.3	0.3	0.6	0.3
Tense / ‘highly strung’	1.2	2.0	7.7	-0.5	0.4	-2.8	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	0.4	-0.9	0.2
Hair/balding pattern: Pattern 4	0.5	1.1	2.4	-0.6	1.5	0.3	1.3
Birth weight of first child	1.4	2.5	4.1	-1.3	-1.1	-1.7	-2.0
Peak expiratory flow (PEF)	0.2	0.4	0.9	0.5	0.5	0.9	0.3
Pulse wave reflection index	1.2	1.5	2.5	-1.3	1.0	1.6	1.0
Ever highly irritable/argumentative for 2 days	6.0	7.2	9.8	-3.1	2.9	1.8	2.7
Loud music exposure frequency	0.8	0.9	1.8	0.0	-0.6	-1.2	-1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	0.6	-0.7	1.1	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.7	0.2	-0.3	-1.6	-0.7
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.9	0.3	-0.5	0.8
Medication: Paracetamol	4.1	6.7	12.4	-1.2	3.5	1.0	3.5
Headache pain in last month	1.6	2.7	4.0	-2.0	1.4	1.1	1.9
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	5.5	0.7	-2.3	-2.1	-1.7
Glaucoma (self-reported)	0.5	0.6	1.4	0.4	-0.1	-1.2	-0.9
Gout (self-reported)	0.1	0.1	0.4	0.1	0.2	0.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	2.5	1.1	0.1	-1.6	0.7
Medication: Amlodipine	1.4	2.0	2.6	-1.1	1.6	1.5	1.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.2	1.5	-0.3	0.1	0.4
Birth weight	0.2	0.3	0.7	-0.9	0.3	-0.6	-0.3
Chronic bronchitis/emphysema (mother)	3.4	3.9	6.1	0.3	2.2	2.5	2.2
High blood pressure (siblings)	1.4	2.0	3.2	-1.2	1.8	0.8	1.6
Forced vital capacity (FVC), Best measure	0.4	1.4	2.9	-1.7	0.4	1.6	-0.2
Body fat percentage	0.1	0.3	0.8	0.3	-0.5	-0.9	-0.5
Leg fat percentage (right)	0.1	0.2	0.6	-0.8	-0.3	-0.3	-0.2
Arm fat-free mass (right)	0.8	4.0	7.5	-0.0	-2.1	-2.0	-2.7
Exposure to tobacco smoke outside home	1.5	2.0	5.4	-1.1	0.5	2.3	1.1
Comparative body size at age 10	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.1
Number of full brothers	1.6	2.0	4.4	0.1	2.1	1.4	1.3
Worry too long after embarrassment	1.4	2.4	7.6	0.8	-0.7	-2.8	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.9	-0.8	1.1	1.4	1.7
Wheeze or whistling in the chest in last year	1.9	3.4	4.7	2.2	-2.2	-1.7	-1.2
Number of children fathered	0.7	0.8	2.4	0.3	-0.8	-1.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	1.9	-0.4	1.3	1.2	1.4
Age at first live birth	0.4	0.7	0.9	-0.5	-0.9	1.0	-0.9
Pulse wave peak to peak time	3.4	4.0	5.7	1.1	-2.2	-2.4	-2.1
Health satisfaction	0.8	1.1	2.2	0.1	1.5	-0.1	1.4
Shortness of breath walking on level ground	0.3	0.3	0.7	0.1	-0.4	0.7	0.8
Qualifications: College or University degree	3.6	11.2	16.1	2.4	-3.5	-3.3	-4.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	0.1	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.3	-0.2	0.3	0.6
Emphysema/chronic bronchitis	1.4	1.5	5.9	2.4	0.2	0.3	0.3
Medication for pain relief, constipation, heartburn	2.8	4.8	9.6	0.8	-3.1	-0.3	-2.9
Neck or shoulder pain in last month	0.9	1.3	1.7	-0.5	1.3	1.3	1.2
Medication: Blood pressure	0.9	1.5	2.9	-0.1	1.7	1.2	1.3
Angina (self-reported)	0.6	0.8	1.6	0.1	0.9	0.9	1.3
Migraine (self-reported)	0.8	1.0	3.2	-1.8	0.5	0.8	0.3
Medication: Ibuprofen	0.2	0.2	0.5	0.3	0.4	-0.7	0.3
Medication: Allopurinol	0.1	0.2	0.7	0.8	-0.3	0.1	-0.0
Medication: Omeprazole	0.8	0.9	2.1	0.7	0.9	-1.5	0.5
Medication: Seretide 50 evohaler	2.0	2.3	4.0	-2.0	1.1	1.8	0.9
Mean time to correctly identify matches	0.2	0.3	0.9	-0.1	0.6	-0.1	1.0
Heart disease (mother)	0.3	0.3	0.6	0.6	-0.6	-0.8	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.5	1.2	0.3	-1.9	0.4
Whole body fat mass	0.4	1.8	3.0	0.5	-1.3	-1.7	-1.5
Leg fat mass (right)	0.3	1.0	1.7	-0.6	-1.0	-1.3	-1.0
Arm predicted mass (right)	0.8	4.3	8.2	0.2	-2.3	-1.9	-2.9
Pulse rate, automated reading	1.6	5.2	10.2	-1.0	-2.9	-1.3	-3.2
Alcohol intake frequency.	0.5	1.1	2.7	-0.9	0.8	-0.6	1.6
Comparative height size at age 10	2.1	11.5	20.2	0.4	-3.5	-3.6	-4.5
Number of full sisters	1.4	1.7	3.8	0.1	1.8	-0.2	2.0
Suffer from ‘nerves’	0.8	1.3	4.1	1.1	-0.1	-2.0	-0.3
Overall health rating	1.0	2.1	3.8	0.6	1.8	-1.1	1.9
Chest pain or discomfort	0.6	0.8	2.2	0.7	-1.5	-0.5	-0.6
Had major operations	0.1	0.1	0.4	0.3	0.2	0.3	0.6
Age at last live birth	0.2	0.2	0.6	-0.8	-0.2	0.5	0.3
Family relationship satisfaction	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.1
Leg pain on walking	2.9	3.6	8.8	-0.3	2.2	0.9	3.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.4	-0.5	1.0	0.6	1.5
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.8	0.4	0.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	0.1	0.7	1.4	0.0
Medication: Aspirin	1.5	2.0	4.2	0.3	1.7	0.9	2.0
Supplements: Vitamin C	0.9	1.1	2.0	0.5	0.9	1.2	1.4
Knee pain experienced in last month	3.0	4.7	9.0	-1.0	2.9	0.6	3.0
Hypertension (Self-reported)	0.7	2.1	4.9	-0.7	2.2	0.4	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	4.1	-1.6	2.0	0.3	1.1
Illnesses of father: Heart disease	1.5	2.0	5.4	-2.3	-0.7	0.5	-1.4
Illnesses of siblings: Diabetes	0.5	0.6	1.3	0.4	1.1	-0.0	0.9
Smoking status: Previous	2.7	4.0	7.7	-0.9	2.8	0.5	2.7
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	4.0	0.2	-1.9	-1.6	-2.0
Whole body fat-free mass	1.2	7.1	10.9	0.7	-2.7	-3.1	-3.3
Leg fat-free mass (right)	1.4	7.4	11.7	1.3	-2.6	-3.4	-3.0
Arm fat percentage (left)	0.3	1.3	3.2	0.9	-0.8	-1.8	-0.7
Average weekly red wine intake	0.5	0.7	1.6	-0.5	1.0	0.2	1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	0.3	0.7	0.3	1.3
Mood swings	0.8	1.4	3.6	1.9	-0.3	-1.3	0.1
Loneliness, isolation	1.0	1.4	3.1	-0.4	-0.9	-1.8	-1.2
Long-standing illness, disability or infirmity	0.5	0.7	1.2	-0.7	1.0	0.2	1.1
Ever had bowel cancer screening	0.8	0.9	1.7	0.8	-0.8	-1.3	-0.9
Diabetes diagnosed by doctor	0.0	0.0	0.2	0.0	0.0	0.4	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.3	-1.5	0.9	0.5	1.1
Friendships satisfaction	0.4	0.5	0.9	-1.0	0.6	-0.8	-0.3
Qualifications: nursing, teaching	1.2	1.9	3.5	0.9	-1.9	-0.5	-1.7
Commuting to job workplace: Walk	1.6	1.8	3.1	-1.0	1.5	0.9	1.8
Eye problems/disorders: Cataract	0.9	1.1	2.6	-0.6	0.4	1.6	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	-1.0	0.0	-0.6	-0.4
Medication for cholesterol	0.6	0.9	2.0	0.3	-1.1	-0.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	-1.2	0.5	-0.6	0.2
Back pain experienced in last month	0.2	0.2	0.8	0.9	0.3	0.1	0.0
Mineral and other dietary supplements	1.2	1.6	2.2	1.1	-1.5	-0.8	-1.5
Breast cancer (self-reported)	1.2	1.4	2.7	-1.1	1.3	0.5	1.6
Asthma (self-reported)	0.0	0.1	0.3	0.2	-0.5	0.1	0.0
Osteoporosis (self-reported)	1.2	1.4	2.7	0.3	1.5	0.7	1.7
Osteoarthritis (self-reported)	0.3	0.4	0.7	0.2	0.6	-0.8	0.7
Medication: Aspirin	1.3	1.8	4.0	0.3	1.5	0.9	2.0
Medication: Gliclazide	1.7	1.9	3.6	-0.8	0.8	1.9	1.6
Illnesses of father: None of the above (group 1)	2.3	2.9	4.2	1.8	-1.5	-2.0	-1.4
Smoking status: Current	1.4	2.3	5.9	2.4	0.6	-0.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	6.6	-2.3	2.6	2.5	2.0
Whole body water mass	1.2	6.7	10.0	0.7	-2.6	-3.1	-3.2
Leg predicted mass (right)	1.3	7.2	11.5	1.4	-2.6	-3.4	-2.9
Arm fat mass (left)	0.6	2.4	4.5	0.8	-1.5	-2.1	-1.5
Number of self-reported non-cancer illnesses	1.9	3.2	6.2	-1.4	2.5	1.0	1.9
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.7	0.8	-0.5	0.6
Miserableness	1.1	1.9	4.2	2.0	-0.2	-1.9	0.3
Guilty feelings	1.0	1.5	4.2	1.1	-0.5	-2.0	-0.6
Wears glasses or contact lenses	0.2	0.2	0.6	-0.2	0.8	-0.3	0.2
Ever taken oral contraceptive pill	0.9	1.0	1.9	-0.5	1.2	0.6	1.4
Hearing aid user	0.7	0.7	2.3	0.5	0.3	0.5	1.5
Mother’s age at death	0.8	1.0	3.7	1.9	-0.2	-0.4	-0.2
Financial situation satisfaction	2.5	3.1	5.3	-1.5	2.3	1.1	1.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	0.7	0.8	-1.0	0.5
Commuting to job workplace: Public transport	1.2	1.5	2.2	1.5	-0.8	-1.1	-1.3
Eye problems/disorders: Glaucoma	1.3	1.5	2.9	0.4	-0.6	-1.7	-1.6
Medication: Blood pressure	1.0	1.9	4.0	-0.9	2.0	0.1	1.7
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.2	-0.1	0.5	-0.5	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	-0.6	0.9	0.5	0.6
High cholesterol (Self-reported)	1.0	1.7	3.4	-1.3	0.4	1.9	1.2
Medication: Bendroflumethiazide	1.1	1.7	5.0	-0.3	2.2	0.2	1.3
Medication: Paracetamol	2.8	4.3	9.0	-1.0	3.0	0.5	2.6
Medication: Lisinopril	5.1	6.6	13.3	-1.0	3.7	1.1	3.3
Medication: Atorvastatin	0.2	0.3	0.8	-0.4	0.1	0.9	0.4
Illnesses of father: High blood pressure	2.3	2.8	6.2	-1.0	2.5	0.2	2.0
Alcohol drinker status: Never	0.6	0.7	1.4	-0.2	0.3	1.2	1.2
Ever smoked	3.2	5.6	14.0	-0.4	2.9	0.1	3.7
Basal metabolic rate	1.2	6.7	9.7	0.7	-2.6	-3.1	-3.1
Leg fat percentage (left)	0.0	0.2	0.6	-0.8	-0.1	-0.3	-0.1
Arm fat-free mass (left)	0.9	4.5	7.7	0.1	-2.4	-2.1	-2.8
Number of operations (self-reported)	0.1	0.2	0.3	0.6	0.1	-0.5	0.5
Average weekly beer plus cider intake	0.4	0.5	0.9	0.6	0.1	0.9	0.9
Irritability	2.6	4.4	5.7	1.3	-2.4	-2.4	-2.1
Risk taking	0.3	0.5	0.8	-0.3	-0.6	0.9	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.9	0.3	-0.1	0.6
Fractured/broken bones in last 5 years	0.5	0.7	1.1	0.7	-1.0	-0.9	-0.7
Age started oral contraceptive pill	1.0	1.2	2.4	-0.9	-1.2	-0.4	-1.6
Diastolic blood pressure, automated reading	0.3	0.8	1.7	-0.4	1.3	-0.6	1.0
Ever depressed for a whole week	1.0	1.3	1.6	1.2	-0.7	-1.2	-1.3
Unable to work because of sickness or disability	2.8	3.6	8.2	0.1	2.3	-1.0	2.9
Commuting to job workplace: Cycle	0.5	0.6	1.0	1.0	-0.8	0.3	-0.9
Myopia	0.3	0.5	1.1	-0.7	-0.2	-0.3	-1.1
Vascular/heart problems diagnosed by doctor	1.2	3.2	7.0	1.0	-2.6	-0.8	-2.0
Cholesterol lowering medication	0.4	0.6	1.1	-0.2	0.5	1.1	1.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.6	0.8	0.9	-1.2	0.4
Pain experienced in last month	1.2	2.1	4.0	0.8	-2.0	-0.4	-1.9
Supplements: Calcium	0.2	0.3	0.4	0.6	-0.7	0.5	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	0.5	-0.5	-1.1	0.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.8	-0.3	1.4	1.7	1.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.5	1.1	0.5	-0.7	1.2
Heart disease (siblings)	0.7	0.9	2.3	0.0	0.8	1.5	0.8
Alcohol drinker status: Previous	2.0	2.2	3.6	-0.9	1.9	1.1	1.9
Pack years of smoking	0.8	1.2	3.9	0.3	-0.9	-2.0	0.1
Impedance of whole body	0.2	0.8	1.3	0.5	-1.1	1.0	-0.9
Leg fat mass (left)	0.2	0.8	1.6	-0.5	-0.8	-1.3	-0.9
Arm predicted mass (left)	0.9	4.6	7.5	-0.1	-2.4	-2.3	-2.7