Hub : Genes

SLC25A35

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0214 0.0097 1.0e-02 0.010 0.003 0.008 0.005 0.007 2.1e-04 3.6e-02 7.5e-04 0.0059 1.3e-03
2 TCGA Breast Invasive Carcinoma 0.0293 0.0166 1.4e-03 0.005 0.014 0.006 NA 0.008 3.1e-02 5.6e-04 2.1e-02 NA 6.7e-03
3 TCGA Lung Adenocarcinoma 0.0217 0.0127 6.1e-03 0.009 0.015 0.001 NA 0.013 2.9e-02 6.7e-03 2.2e-01 NA 1.0e-02
4 TCGA Prostate Adenocarcinoma 0.0933 0.0317 7.5e-09 0.060 0.103 0.106 NA 0.105 6.9e-07 7.3e-11 3.9e-11 NA 4.5e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.2 2.0 3.5 -1.9 1.3 0.9 1.3
Bipolar Disorder or Schizophrenia 1.1 2.7 3.6 -1.0 1.9 1.9 1.6
Depressed Affect (Nagel 2018) 1.5 3.1 6.4 2.5 -0.7 -2.4 0.0
Depression (Nagel 2018) 0.8 1.2 3.8 1.9 0.6 -0.1 0.9
Intelligence (Savage-Jansen 2018) 1.6 4.8 10.4 0.4 -3.2 -0.7 -2.8
Neuroticism (Nagel 2018) 1.5 3.5 10.2 1.9 -0.5 -3.2 -0.1
Schizophrenia (2018) 0.7 1.4 2.6 0.2 1.4 1.6 1.0
Schizophrenia vs Biploar Disorder 0.3 0.5 1.1 1.0 0.3 -0.8 0.2
Worry (Nagel 2018) 0.8 1.7 5.6 0.3 0.8 -2.4 0.6
Alzheimer’s Disease (in mother) 1.3 1.5 2.3 -0.9 1.3 1.5 1.1
Alzheimer’s Disease (in father) 1.1 1.2 2.0 1.4 -1.1 -1.0 -0.8
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.1 0.4 0.4 0.6
Crohns Disease (2017) 0.1 0.3 0.7 0.5 -0.3 -0.9 0.5
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 -0.2 0.0 -0.3 0.6
Ulcerative Colitis (UC) 0.1 0.2 0.3 -0.5 0.4 0.3 0.4
Major Depression (MDD) 0.6 0.7 1.6 1.2 0.8 -0.7 0.2
Reaction Time 0.4 0.7 1.6 1.2 -0.0 -0.8 0.9
Verbal and Numeric Reasoning (VNR) 3.8 9.2 17.9 0.1 -4.1 -1.4 -4.2
Breast Cancer 0.5 1.2 3.2 1.8 -0.6 1.0 -0.6
Ovarian Cancer 0.3 0.4 1.3 1.1 -0.6 0.1 -0.2
Prostate Cancer 1.2 1.6 5.2 1.0 0.5 2.3 0.4
Age at First Birth 0.0 0.1 0.1 -0.3 -0.3 -0.3 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 0.9 1.9 0.8 -0.5 -0.9 -1.4
Coronary Artery Disease (CAD) 1.4 1.7 2.5 -0.1 1.6 1.5 1.4
Crohns Disease (2012) 0.4 0.7 1.9 1.4 -0.7 -0.1 0.5
Mean Putamen Volume 2.0 2.3 4.1 1.2 -1.4 -2.0 -1.2
Fasting Glucose 1.7 2.1 6.0 0.5 -0.8 -2.4 -1.2
HbA1C 1.6 1.8 3.5 -1.5 0.9 1.9 0.7
HDL Cholesterol 0.6 0.9 2.2 0.3 -1.5 0.2 -1.2
LDL Cholesterol 2.8 4.4 15.4 -1.5 0.1 3.9 0.2
Lupus 0.7 1.1 1.5 -0.0 1.1 1.2 1.2
Neuroticism (2016) 0.5 0.7 1.1 -1.1 0.9 -0.3 0.8
Primary Biliary Cirrhosis 0.6 0.9 1.9 -0.5 1.4 1.1 0.6
Rheumatoid Arthritis 0.5 0.7 2.1 -0.2 0.6 1.5 0.6
Schizophrenia (2014) 0.0 0.1 0.4 0.0 0.6 0.1 0.2
Triglycerides 0.4 0.7 2.0 0.3 1.4 0.1 0.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 3.5 -0.3 1.9 0.8 1.5
Ulcerative Colitis 1.3 1.9 2.7 -1.7 1.4 1.0 1.3
Blood Eosinophil Count 1.6 12.6 20.3 2.6 -3.9 -4.5 -2.8
Blood Platelet Count 0.4 5.1 6.4 -2.5 2.5 1.9 2.0
Blood Red Count 3.9 37.2 84.6 -2.6 5.1 9.2 5.6
Blood White Count 1.0 7.3 18.5 2.2 1.1 -4.3 2.2
Heel T-Score 0.2 1.9 5.5 -0.9 0.6 2.3 1.0
BMI 0.3 1.8 3.3 0.4 1.0 -1.6 1.8
Height 2.2 42.3 82.4 1.4 -8.3 -4.1 -9.1
Waist Hip Ratio (WHR) 0.3 1.5 4.4 -1.1 -0.2 2.1 0.8
Systolic Blood Pressure 2.9 14.5 27.8 -1.2 5.3 2.2 4.9
Smoking Status 2.3 5.5 13.2 1.4 2.6 -0.2 3.6
Allergy or Eczema 1.3 3.4 6.5 -0.1 2.5 1.0 2.5
Cardiovascular Disease 1.4 4.8 8.2 -1.3 2.9 1.5 2.6
Hypothyroidism (self reported) 1.2 2.7 7.0 1.8 -0.6 -2.6 0.3
Respiratory disease 0.3 0.8 1.4 1.2 -1.0 -0.6 -0.3
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 -0.3 0.3 0.3 0.1
Lung FEV1/FVC ratio 0.8 4.2 7.6 1.6 -1.8 -2.8 -1.8
Lung FVC 2.8 14.4 23.4 -2.8 3.9 4.8 3.3
Neuroticism 1.2 2.8 10.1 1.0 0.3 -3.2 0.2
Chronotype (morning person) 1.1 2.5 4.3 2.1 1.4 1.0 1.7
Hair Pigment 0.1 1.9 2.9 -0.2 1.4 1.6 1.7
Tanning 0.2 2.9 5.7 1.2 2.0 0.7 2.4
Hand grip strength (left) 0.2 0.4 0.9 0.8 -0.1 0.9 -0.4
Number of treatments/medications taken 3.4 6.2 11.2 -0.3 3.3 1.6 3.3
Average weekly spirits intake 0.6 0.7 1.7 -0.6 0.3 0.9 1.3
Sensitivity / hurt feelings 0.3 0.6 0.8 -0.1 0.9 -0.9 0.8
Frequency of depressed mood in last 2 weeks 0.7 0.9 2.5 1.6 -0.1 -0.9 0.6
Hearing difficulty/problems: Yes 0.8 1.2 3.2 1.3 -0.1 -1.8 -0.2
Relative age of first facial hair 1.4 2.9 7.3 -0.1 -2.7 -0.9 -1.8
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 0.9 -0.0 -0.3 0.5
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.5 1.1 1.2 0.3 1.2
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.2 0.1 0.0 -0.6
Systolic blood pressure, automated reading 0.8 2.3 5.0 -0.5 2.2 0.8 1.9
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 -0.2 -0.7 -0.3 -0.5
Angina 0.6 0.8 1.6 -0.1 1.0 0.7 1.3
Medication for hormone replacement therapy 0.4 0.4 1.0 1.0 -0.1 -0.8 0.2
Vitamin and mineral supplements 1.3 1.7 6.0 -2.4 -0.0 -0.4 -0.8
Supplements: Zinc 0.7 0.7 1.4 0.0 1.1 0.5 1.2
Medication: Co-codamol 0.3 0.4 0.9 1.0 0.2 0.2 0.7
Medication: Metformin 0.5 0.7 1.3 -0.7 0.7 1.1 0.9
Diabetes (father) 2.2 2.7 4.8 -0.5 2.2 1.2 2.0
Diabetes (mother) 3.0 3.8 6.4 -1.3 1.8 2.0 2.5
Severe depression (siblings) 3.3 3.7 6.2 -2.5 1.7 1.8 1.6
Pack years adult smoking proportion 1.4 2.2 6.9 0.7 -1.2 -2.6 -0.2
Impedance of leg (right) 0.3 1.5 3.9 -1.3 -0.6 2.0 -0.5
Leg fat-free mass (left) 1.5 7.9 12.2 1.4 -2.8 -3.5 -3.0
Trunk fat percentage 0.2 0.6 1.0 0.5 -0.7 -1.0 -0.9
Hand grip strength (right) 0.3 0.7 1.4 1.0 -0.5 1.2 -0.5
Townsend deprivation index at recruitment 0.9 1.3 3.3 -0.4 1.2 0.6 1.8
Current tobacco smoking 1.2 2.0 5.1 2.2 0.6 -0.6 1.5
Average weekly fortified wine intake 0.9 1.1 3.5 -1.9 -0.5 -0.1 -0.8
Maternal smoking around birth 0.4 0.6 1.7 1.3 0.4 0.4 0.4
Fed-up feelings 1.3 2.4 4.4 2.1 -1.1 -2.0 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 3.5 1.9 -0.4 -0.4 0.5
Relative age voice broke 1.2 1.8 3.4 -0.2 -1.9 -0.9 -1.7
Taking other prescription medications 1.1 1.7 3.8 -0.2 1.6 -0.5 1.9
Age when periods started (menarche) 0.1 0.4 1.0 -0.0 -1.0 0.3 -0.6
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.7 0.8 0.0 -1.3 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.8 -0.3 0.2 0.6 1.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.6 -0.8 1.1 -0.1 1.3
Qualifications: CSEs or equivalent 6.0 7.9 11.7 -0.8 3.1 3.1 3.4
Serious illness, injury or assault to yourself 0.6 0.7 1.7 1.0 -0.5 -1.3 -0.0
High blood pressure 0.9 2.5 5.9 -0.8 2.4 0.4 1.8
Hayfever, allergic rhinitis or eczema 1.0 2.2 4.1 0.1 2.0 1.0 2.0
Multivitamins +/- minerals 0.1 0.2 0.4 0.7 -0.2 0.4 0.3
Stomach or abdominal pain in last month 0.6 0.8 1.8 0.9 -0.5 -1.3 -0.3
Supplements: Glucosamine 0.4 0.5 1.4 0.3 0.6 0.0 1.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 -0.4 -0.9 -0.9 -0.4
Medication: Atenolol 0.5 0.6 1.5 -0.7 1.2 0.4 0.7
Medication: Levothyroxine sodium 1.0 1.6 3.6 1.9 -0.9 -1.5 0.1
Sitting height 2.0 14.1 25.1 0.0 -4.5 -3.3 -5.0
Chronic bronchitis/emphysema (father) 1.1 1.3 2.6 -0.3 0.4 1.6 1.6
High blood pressure (mother) 0.3 0.4 1.4 -0.1 -0.1 -1.2 -0.3
Body mass index (BMI) 0.1 0.5 1.7 -0.2 0.3 -1.3 0.3
Impedance of leg (left) 0.4 1.9 5.5 -1.4 -0.1 2.4 -0.3
Leg predicted mass (left) 1.5 7.9 12.5 1.3 -2.9 -3.5 -3.0
Trunk fat mass 0.6 2.4 3.4 0.7 -1.6 -1.8 -1.9
Waist circumference 0.1 0.5 1.7 -0.2 -0.3 -1.3 -0.5
Number of incorrect matches in round 3.5 5.8 8.5 -2.5 2.9 0.4 2.9
Past tobacco smoking 3.3 6.1 14.1 0.3 -3.2 -0.3 -3.8
Alcohol usually taken with meals 1.3 2.2 4.2 -1.6 2.0 0.8 1.1
Nervous feelings 0.9 1.7 3.0 -0.3 1.7 -1.2 1.5
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 6.4 0.9 -0.0 -2.5 -0.0
Hearing difficulty/problems with background noise 0.2 0.4 1.5 0.1 1.2 -0.1 0.1
Hair/balding pattern: Pattern 2 0.8 1.0 3.7 -0.0 0.3 -1.9 0.4
Had menopause 0.2 0.3 0.9 -0.2 0.4 0.9 -0.1
Had other major operations 2.3 2.8 3.8 1.9 -1.5 -1.9 -1.3
Forced vital capacity (FVC) 0.2 0.7 1.8 -0.6 -0.3 1.3 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 1.7 -0.4 0.5 1.0 1.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 -0.1 1.3 0.7 0.3
Qualifications: None of the above 1.3 2.8 4.8 -0.8 2.0 1.3 2.2
Financial difficulties in last 2 years 0.4 0.5 1.0 -0.2 0.6 -1.0 0.8
Mouth/teeth dental problems 0.3 0.5 1.2 0.3 -0.8 0.3 -1.1
Heart attack 1.2 1.6 2.8 -0.3 1.2 1.7 1.3
Allergy 0.5 1.1 2.2 -0.8 -1.1 -0.5 -1.5
Pain all over the body in last month 1.3 1.3 3.5 -1.9 1.4 -0.1 0.3
Diabetes (self-reported) 0.1 0.1 0.2 -0.1 0.4 0.3 0.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 -0.3 0.7 0.2 -0.1
Medication: Ramipril 0.7 0.9 1.7 -0.6 1.3 0.5 1.2
Medication: Simvastatin 1.7 2.5 4.1 -0.3 1.9 2.0 1.6
Fluid intelligence score 4.7 9.7 17.7 0.3 -4.2 -2.3 -4.0
Illnesses of siblings 0.4 0.6 1.4 0.3 -1.2 -0.5 -0.8
Neuroticism score 1.4 2.8 8.7 1.5 -0.5 -3.0 -0.4
Weight 1.0 4.9 7.2 0.3 -2.3 -2.6 -2.7
Impedance of arm (right) 0.6 2.6 3.9 2.0 -1.8 -0.8 -1.6
Arm fat percentage (right) 0.3 1.2 3.4 0.9 -0.6 -1.8 -0.5
Trunk fat-free mass 1.2 7.0 11.8 0.5 -2.7 -3.0 -3.4
Hip circumference 0.8 3.2 8.7 1.0 -1.0 -2.9 -1.5
Time employed in main current job 0.9 1.0 2.4 -1.6 0.4 1.2 -0.2
Alcohol intake versus 10 years previously 0.1 0.2 0.5 0.1 -0.3 -0.7 0.3
Father’s age at death 1.0 1.4 2.3 1.4 -1.5 -0.9 -0.8
Worrier / anxious feelings 1.4 2.7 6.9 2.0 0.2 -2.6 0.1
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 4.1 1.0 1.0 0.4 2.0
Falls in the last year 0.9 1.2 3.6 -1.9 0.4 -1.0 0.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.5 0.7 -0.1 0.6 0.7
Number of live births 2.4 3.5 5.5 -1.7 2.3 -0.2 2.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.6 -0.4 -0.6 0.4 -0.8
Pulse rate 0.9 1.5 3.6 -0.6 -1.0 -0.9 -1.9
Happiness 0.7 0.8 1.5 0.3 -0.5 -1.2 -1.2
Noisy workplace 4.4 5.4 10.9 0.0 2.9 1.6 3.3
Qualifications: A levels/AS levels or equivalent 2.6 5.8 10.7 1.3 -3.0 -1.3 -3.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 0.4 -0.7 0.0 0.2
Mouth/teeth dental problems: Dentures 1.0 1.7 4.1 1.1 1.1 0.4 2.0
Asthma 0.1 0.1 0.4 0.1 -0.3 0.6 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.0 0.5 0.8 -0.5 1.0
Medication: Cholesterol lowering 2.3 3.7 5.1 -0.8 2.2 2.2 2.0
Depression (self-reported) 1.0 1.2 3.7 0.5 0.9 0.5 1.9
Medication: Lansoprazole 2.7 3.1 7.8 -2.8 1.4 1.2 1.0
Prospective memory result 2.6 3.2 5.5 -0.7 2.4 1.2 2.3
Lung cancer (father) 3.7 4.3 4.8 2.2 -2.2 -2.1 -1.8
Illnesses of mother 3.1 3.9 6.4 0.8 -2.5 -1.9 -2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.0 -1.4 0.1 0.4 -0.4
Pulse wave Arterial Stiffness index 2.2 2.5 3.6 -0.8 1.8 1.9 1.7
Impedance of arm (left) 0.7 3.2 5.0 2.2 -2.0 -0.7 -1.8
Arm fat mass (right) 0.5 2.1 4.6 0.5 -1.3 -2.1 -1.4
Trunk predicted mass 1.3 7.5 12.5 0.6 -2.8 -3.0 -3.5
Standing height 2.1 20.8 41.1 1.1 -5.5 -3.2 -6.4
Length of working week for main job 0.3 0.3 1.0 0.3 -1.0 0.0 -0.1
Exposure to tobacco smoke at home 1.5 1.6 2.5 -1.6 0.8 1.2 1.3
Breastfed as a baby 0.1 0.2 0.4 -0.3 0.3 0.6 0.3
Tense / ‘highly strung’ 1.2 2.0 7.7 -0.5 0.4 -2.8 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.9 -0.9 0.4 -0.9 0.2
Hair/balding pattern: Pattern 4 0.5 1.1 2.4 -0.6 1.5 0.3 1.3
Birth weight of first child 1.4 2.5 4.1 -1.3 -1.1 -1.7 -2.0
Peak expiratory flow (PEF) 0.2 0.4 0.9 0.5 0.5 0.9 0.3
Pulse wave reflection index 1.2 1.5 2.5 -1.3 1.0 1.6 1.0
Ever highly irritable/argumentative for 2 days 6.0 7.2 9.8 -3.1 2.9 1.8 2.7
Loud music exposure frequency 0.8 0.9 1.8 0.0 -0.6 -1.2 -1.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.4 0.6 -0.7 1.1 -1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.7 0.2 -0.3 -1.6 -0.7
Blood clot in the leg (DVT) 0.4 0.5 0.8 0.9 0.3 -0.5 0.8
Medication: Paracetamol 4.1 6.7 12.4 -1.2 3.5 1.0 3.5
Headache pain in last month 1.6 2.7 4.0 -2.0 1.4 1.1 1.9
Medication for cholesterol, blood pressure or diabetes 2.0 3.4 5.5 0.7 -2.3 -2.1 -1.7
Glaucoma (self-reported) 0.5 0.6 1.4 0.4 -0.1 -1.2 -0.9
Gout (self-reported) 0.1 0.1 0.4 0.1 0.2 0.1 0.6
Hypothyroidism/myxoedema (self-reported) 0.5 1.1 2.5 1.1 0.1 -1.6 0.7
Medication: Amlodipine 1.4 2.0 2.6 -1.1 1.6 1.5 1.4
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.2 1.5 -0.3 0.1 0.4
Birth weight 0.2 0.3 0.7 -0.9 0.3 -0.6 -0.3
Chronic bronchitis/emphysema (mother) 3.4 3.9 6.1 0.3 2.2 2.5 2.2
High blood pressure (siblings) 1.4 2.0 3.2 -1.2 1.8 0.8 1.6
Forced vital capacity (FVC), Best measure 0.4 1.4 2.9 -1.7 0.4 1.6 -0.2
Body fat percentage 0.1 0.3 0.8 0.3 -0.5 -0.9 -0.5
Leg fat percentage (right) 0.1 0.2 0.6 -0.8 -0.3 -0.3 -0.2
Arm fat-free mass (right) 0.8 4.0 7.5 -0.0 -2.1 -2.0 -2.7
Exposure to tobacco smoke outside home 1.5 2.0 5.4 -1.1 0.5 2.3 1.1
Comparative body size at age 10 0.0 0.0 0.1 0.3 -0.1 -0.2 -0.1
Number of full brothers 1.6 2.0 4.4 0.1 2.1 1.4 1.3
Worry too long after embarrassment 1.4 2.4 7.6 0.8 -0.7 -2.8 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 2.9 -0.8 1.1 1.4 1.7
Wheeze or whistling in the chest in last year 1.9 3.4 4.7 2.2 -2.2 -1.7 -1.2
Number of children fathered 0.7 0.8 2.4 0.3 -0.8 -1.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 1.9 -0.4 1.3 1.2 1.4
Age at first live birth 0.4 0.7 0.9 -0.5 -0.9 1.0 -0.9
Pulse wave peak to peak time 3.4 4.0 5.7 1.1 -2.2 -2.4 -2.1
Health satisfaction 0.8 1.1 2.2 0.1 1.5 -0.1 1.4
Shortness of breath walking on level ground 0.3 0.3 0.7 0.1 -0.4 0.7 0.8
Qualifications: College or University degree 3.6 11.2 16.1 2.4 -3.5 -3.3 -4.0
Eye problems/disorders: None of the above 0.1 0.1 0.1 -0.3 0.1 -0.2 -0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.4 -0.3 -0.2 0.3 0.6
Emphysema/chronic bronchitis 1.4 1.5 5.9 2.4 0.2 0.3 0.3
Medication for pain relief, constipation, heartburn 2.8 4.8 9.6 0.8 -3.1 -0.3 -2.9
Neck or shoulder pain in last month 0.9 1.3 1.7 -0.5 1.3 1.3 1.2
Medication: Blood pressure 0.9 1.5 2.9 -0.1 1.7 1.2 1.3
Angina (self-reported) 0.6 0.8 1.6 0.1 0.9 0.9 1.3
Migraine (self-reported) 0.8 1.0 3.2 -1.8 0.5 0.8 0.3
Medication: Ibuprofen 0.2 0.2 0.5 0.3 0.4 -0.7 0.3
Medication: Allopurinol 0.1 0.2 0.7 0.8 -0.3 0.1 -0.0
Medication: Omeprazole 0.8 0.9 2.1 0.7 0.9 -1.5 0.5
Medication: Seretide 50 evohaler 2.0 2.3 4.0 -2.0 1.1 1.8 0.9
Mean time to correctly identify matches 0.2 0.3 0.9 -0.1 0.6 -0.1 1.0
Heart disease (mother) 0.3 0.3 0.6 0.6 -0.6 -0.8 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.5 1.2 0.3 -1.9 0.4
Whole body fat mass 0.4 1.8 3.0 0.5 -1.3 -1.7 -1.5
Leg fat mass (right) 0.3 1.0 1.7 -0.6 -1.0 -1.3 -1.0
Arm predicted mass (right) 0.8 4.3 8.2 0.2 -2.3 -1.9 -2.9
Pulse rate, automated reading 1.6 5.2 10.2 -1.0 -2.9 -1.3 -3.2
Alcohol intake frequency. 0.5 1.1 2.7 -0.9 0.8 -0.6 1.6
Comparative height size at age 10 2.1 11.5 20.2 0.4 -3.5 -3.6 -4.5
Number of full sisters 1.4 1.7 3.8 0.1 1.8 -0.2 2.0
Suffer from ‘nerves’ 0.8 1.3 4.1 1.1 -0.1 -2.0 -0.3
Overall health rating 1.0 2.1 3.8 0.6 1.8 -1.1 1.9
Chest pain or discomfort 0.6 0.8 2.2 0.7 -1.5 -0.5 -0.6
Had major operations 0.1 0.1 0.4 0.3 0.2 0.3 0.6
Age at last live birth 0.2 0.2 0.6 -0.8 -0.2 0.5 0.3
Family relationship satisfaction 0.1 0.1 0.2 0.4 -0.2 -0.4 -0.1
Leg pain on walking 2.9 3.6 8.8 -0.3 2.2 0.9 3.0
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.4 -0.5 1.0 0.6 1.5
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.6 -0.8 0.4 0.2 0.7
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 2.0 0.1 0.7 1.4 0.0
Medication: Aspirin 1.5 2.0 4.2 0.3 1.7 0.9 2.0
Supplements: Vitamin C 0.9 1.1 2.0 0.5 0.9 1.2 1.4
Knee pain experienced in last month 3.0 4.7 9.0 -1.0 2.9 0.6 3.0
Hypertension (Self-reported) 0.7 2.1 4.9 -0.7 2.2 0.4 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 4.1 -1.6 2.0 0.3 1.1
Illnesses of father: Heart disease 1.5 2.0 5.4 -2.3 -0.7 0.5 -1.4
Illnesses of siblings: Diabetes 0.5 0.6 1.3 0.4 1.1 -0.0 0.9
Smoking status: Previous 2.7 4.0 7.7 -0.9 2.8 0.5 2.7
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 4.0 0.2 -1.9 -1.6 -2.0
Whole body fat-free mass 1.2 7.1 10.9 0.7 -2.7 -3.1 -3.3
Leg fat-free mass (right) 1.4 7.4 11.7 1.3 -2.6 -3.4 -3.0
Arm fat percentage (left) 0.3 1.3 3.2 0.9 -0.8 -1.8 -0.7
Average weekly red wine intake 0.5 0.7 1.6 -0.5 1.0 0.2 1.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 0.3 0.7 0.3 1.3
Mood swings 0.8 1.4 3.6 1.9 -0.3 -1.3 0.1
Loneliness, isolation 1.0 1.4 3.1 -0.4 -0.9 -1.8 -1.2
Long-standing illness, disability or infirmity 0.5 0.7 1.2 -0.7 1.0 0.2 1.1
Ever had bowel cancer screening 0.8 0.9 1.7 0.8 -0.8 -1.3 -0.9
Diabetes diagnosed by doctor 0.0 0.0 0.2 0.0 0.0 0.4 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.3 -1.5 0.9 0.5 1.1
Friendships satisfaction 0.4 0.5 0.9 -1.0 0.6 -0.8 -0.3
Qualifications: nursing, teaching 1.2 1.9 3.5 0.9 -1.9 -0.5 -1.7
Commuting to job workplace: Walk 1.6 1.8 3.1 -1.0 1.5 0.9 1.8
Eye problems/disorders: Cataract 0.9 1.1 2.6 -0.6 0.4 1.6 1.0
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.9 -1.0 0.0 -0.6 -0.4
Medication for cholesterol 0.6 0.9 2.0 0.3 -1.1 -0.1 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.4 -1.2 0.5 -0.6 0.2
Back pain experienced in last month 0.2 0.2 0.8 0.9 0.3 0.1 0.0
Mineral and other dietary supplements 1.2 1.6 2.2 1.1 -1.5 -0.8 -1.5
Breast cancer (self-reported) 1.2 1.4 2.7 -1.1 1.3 0.5 1.6
Asthma (self-reported) 0.0 0.1 0.3 0.2 -0.5 0.1 0.0
Osteoporosis (self-reported) 1.2 1.4 2.7 0.3 1.5 0.7 1.7
Osteoarthritis (self-reported) 0.3 0.4 0.7 0.2 0.6 -0.8 0.7
Medication: Aspirin 1.3 1.8 4.0 0.3 1.5 0.9 2.0
Medication: Gliclazide 1.7 1.9 3.6 -0.8 0.8 1.9 1.6
Illnesses of father: None of the above (group 1) 2.3 2.9 4.2 1.8 -1.5 -2.0 -1.4
Smoking status: Current 1.4 2.3 5.9 2.4 0.6 -0.3 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.6 6.6 -2.3 2.6 2.5 2.0
Whole body water mass 1.2 6.7 10.0 0.7 -2.6 -3.1 -3.2
Leg predicted mass (right) 1.3 7.2 11.5 1.4 -2.6 -3.4 -2.9
Arm fat mass (left) 0.6 2.4 4.5 0.8 -1.5 -2.1 -1.5
Number of self-reported non-cancer illnesses 1.9 3.2 6.2 -1.4 2.5 1.0 1.9
Average weekly champagne plus white wine intake 0.3 0.4 0.7 0.7 0.8 -0.5 0.6
Miserableness 1.1 1.9 4.2 2.0 -0.2 -1.9 0.3
Guilty feelings 1.0 1.5 4.2 1.1 -0.5 -2.0 -0.6
Wears glasses or contact lenses 0.2 0.2 0.6 -0.2 0.8 -0.3 0.2
Ever taken oral contraceptive pill 0.9 1.0 1.9 -0.5 1.2 0.6 1.4
Hearing aid user 0.7 0.7 2.3 0.5 0.3 0.5 1.5
Mother’s age at death 0.8 1.0 3.7 1.9 -0.2 -0.4 -0.2
Financial situation satisfaction 2.5 3.1 5.3 -1.5 2.3 1.1 1.8
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.0 0.7 0.8 -1.0 0.5
Commuting to job workplace: Public transport 1.2 1.5 2.2 1.5 -0.8 -1.1 -1.3
Eye problems/disorders: Glaucoma 1.3 1.5 2.9 0.4 -0.6 -1.7 -1.6
Medication: Blood pressure 1.0 1.9 4.0 -0.9 2.0 0.1 1.7
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.2 -0.1 0.5 -0.5 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 -0.6 0.9 0.5 0.6
High cholesterol (Self-reported) 1.0 1.7 3.4 -1.3 0.4 1.9 1.2
Medication: Bendroflumethiazide 1.1 1.7 5.0 -0.3 2.2 0.2 1.3
Medication: Paracetamol 2.8 4.3 9.0 -1.0 3.0 0.5 2.6
Medication: Lisinopril 5.1 6.6 13.3 -1.0 3.7 1.1 3.3
Medication: Atorvastatin 0.2 0.3 0.8 -0.4 0.1 0.9 0.4
Illnesses of father: High blood pressure 2.3 2.8 6.2 -1.0 2.5 0.2 2.0
Alcohol drinker status: Never 0.6 0.7 1.4 -0.2 0.3 1.2 1.2
Ever smoked 3.2 5.6 14.0 -0.4 2.9 0.1 3.7
Basal metabolic rate 1.2 6.7 9.7 0.7 -2.6 -3.1 -3.1
Leg fat percentage (left) 0.0 0.2 0.6 -0.8 -0.1 -0.3 -0.1
Arm fat-free mass (left) 0.9 4.5 7.7 0.1 -2.4 -2.1 -2.8
Number of operations (self-reported) 0.1 0.2 0.3 0.6 0.1 -0.5 0.5
Average weekly beer plus cider intake 0.4 0.5 0.9 0.6 0.1 0.9 0.9
Irritability 2.6 4.4 5.7 1.3 -2.4 -2.4 -2.1
Risk taking 0.3 0.5 0.8 -0.3 -0.6 0.9 0.8
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.8 0.9 0.3 -0.1 0.6
Fractured/broken bones in last 5 years 0.5 0.7 1.1 0.7 -1.0 -0.9 -0.7
Age started oral contraceptive pill 1.0 1.2 2.4 -0.9 -1.2 -0.4 -1.6
Diastolic blood pressure, automated reading 0.3 0.8 1.7 -0.4 1.3 -0.6 1.0
Ever depressed for a whole week 1.0 1.3 1.6 1.2 -0.7 -1.2 -1.3
Unable to work because of sickness or disability 2.8 3.6 8.2 0.1 2.3 -1.0 2.9
Commuting to job workplace: Cycle 0.5 0.6 1.0 1.0 -0.8 0.3 -0.9
Myopia 0.3 0.5 1.1 -0.7 -0.2 -0.3 -1.1
Vascular/heart problems diagnosed by doctor 1.2 3.2 7.0 1.0 -2.6 -0.8 -2.0
Cholesterol lowering medication 0.4 0.6 1.1 -0.2 0.5 1.1 1.0
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.6 0.8 0.9 -1.2 0.4
Pain experienced in last month 1.2 2.1 4.0 0.8 -2.0 -0.4 -1.9
Supplements: Calcium 0.2 0.3 0.4 0.6 -0.7 0.5 0.2
Basal cell carcinoma (self-reported) 0.4 0.5 1.3 0.5 -0.5 -1.1 0.2
Heart attack/myocardial infarction (self-reported) 1.4 1.8 2.8 -0.3 1.4 1.7 1.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.5 1.1 0.5 -0.7 1.2
Heart disease (siblings) 0.7 0.9 2.3 0.0 0.8 1.5 0.8
Alcohol drinker status: Previous 2.0 2.2 3.6 -0.9 1.9 1.1 1.9
Pack years of smoking 0.8 1.2 3.9 0.3 -0.9 -2.0 0.1
Impedance of whole body 0.2 0.8 1.3 0.5 -1.1 1.0 -0.9
Leg fat mass (left) 0.2 0.8 1.6 -0.5 -0.8 -1.3 -0.9
Arm predicted mass (left) 0.9 4.6 7.5 -0.1 -2.4 -2.3 -2.7