[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr12:47,671,905-51,912,062

Best TWAS P=1.33e-23 · Best GWAS P=2.72e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AQP5	0.09	0.06	lasso	1	0.04	1.4e-05	6.0	-6.0	1.8e-09	-0.24	0.99	0.01	TRUE
2	CommonMind	Brain Pre-frontal Cortex	DIP2B	0.11	0.10	enet	16	0.13	2.6e-15	7.5	7.0	2.0e-12	0.64	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAIM2	0.09	0.00	bslmm	336	0.03	3.7e-04	-1.9	-5.5	4.0e-08	-0.07	0.26	0.03	FALSE
4	CommonMind	Brain Pre-frontal Cortex	FMNL3	0.03	0.03	bslmm	343	0.03	3.2e-04	-4.2	6.6	3.9e-11	-0.03	0.76	0.01	TRUE
5	CommonMind	Brain Pre-frontal Cortex	SENP1	0.05	0.02	blup	555	0.04	1.7e-05	6.6	-7.6	2.9e-14	-0.07	0.03	0.97	TRUE
6	CommonMind	Brain Pre-frontal Cortex	TMEM106C	0.13	0.06	enet	21	0.11	3.2e-13	5.6	5.2	1.5e-07	0.03	0.79	0.20	FALSE
7	CommonMind	Brain Pre-frontal Cortex	ZNF641	0.03	0.01	blup	489	0.02	6.4e-04	7.1	5.2	2.2e-07	0.06	0.03	0.94	FALSE
8	GTEx	Adipose Subcutaneous	ZNF641	0.10	0.10	lasso	4	0.10	2.8e-08	7.2	7.2	5.9e-13	0.08	0.01	0.99	FALSE
9	GTEx	Adipose Subcutaneous	RP1-228P16.1	0.20	0.20	lasso	8	0.22	4.7e-18	5.9	-6.3	2.2e-10	-0.06	0.54	0.46	FALSE
10	GTEx	Adipose Visceral Omentum	ZNF641	0.14	0.09	lasso	4	0.08	3.7e-05	7.2	6.3	3.7e-10	0.07	0.01	0.99	FALSE
11	GTEx	Adipose Visceral Omentum	ASB8	0.10	0.00	lasso	6	0.00	6.8e-01	6.1	6.2	5.1e-10	0.04	0.07	0.79	FALSE
12	GTEx	Adipose Visceral Omentum	RP1-228P16.1	0.18	0.13	lasso	4	0.15	2.3e-08	5.6	-5.9	4.2e-09	-0.08	0.41	0.59	FALSE
13	GTEx	Adrenal Gland	ZNF641	0.31	0.18	lasso	3	0.21	4.2e-08	7.0	6.3	3.2e-10	0.05	0.02	0.98	FALSE
14	GTEx	Adrenal Gland	RP1-228P16.1	0.19	0.20	lasso	5	0.15	4.4e-06	5.7	-5.7	1.3e-08	-0.03	0.17	0.82	FALSE
15	GTEx	Artery Aorta	ATF1	0.26	0.29	lasso	2	0.28	1.5e-15	-5.6	-5.7	1.4e-08	-0.52	1.00	0.00	FALSE
16	GTEx	Artery Aorta	ZNF641	0.22	0.13	enet	30	0.18	4.9e-10	6.6	5.6	1.7e-08	0.08	0.01	0.99	FALSE
17	GTEx	Artery Aorta	RP1-228P16.1	0.16	0.05	enet	28	0.11	1.7e-06	6.6	-5.3	9.3e-08	-0.08	0.15	0.85	FALSE
18	GTEx	Artery Coronary	ATF1	0.20	0.09	lasso	4	0.05	1.2e-02	-5.4	-5.2	2.4e-07	-0.50	0.22	0.19	FALSE
19	GTEx	Artery Coronary	RP1-228P16.1	0.12	0.06	lasso	2	0.03	2.6e-02	5.7	-6.0	2.6e-09	-0.04	0.20	0.62	FALSE
20	GTEx	Artery Tibial	ATF1	0.24	0.26	lasso	7	0.25	2.7e-19	-5.6	-5.5	3.1e-08	-0.51	1.00	0.00	FALSE
21	GTEx	Artery Tibial	ZNF641	0.19	0.16	lasso	5	0.16	1.6e-12	7.2	7.2	6.3e-13	0.08	0.01	0.99	FALSE
22	GTEx	Artery Tibial	RP1-228P16.1	0.16	0.14	lasso	14	0.15	5.9e-12	5.7	-6.0	2.4e-09	-0.05	0.72	0.28	FALSE
23	GTEx	Artery Tibial	RP4-605O3.4	0.04	0.01	lasso	4	0.00	3.2e-01	9.9	7.8	4.8e-15	0.96	0.02	0.94	TRUE
24	GTEx	Brain Caudate basal ganglia	LIMA1	0.18	0.12	lasso	5	0.07	3.9e-03	6.2	5.6	2.3e-08	0.86	0.02	0.85	FALSE
25	GTEx	Brain Caudate basal ganglia	ASB8	0.18	0.02	lasso	4	0.04	2.1e-02	5.3	5.6	1.9e-08	0.03	0.06	0.58	FALSE
26	GTEx	Brain Caudate basal ganglia	RP1-228P16.1	0.14	0.12	lasso	4	0.11	5.7e-04	5.6	-5.8	7.0e-09	-0.06	0.06	0.81	FALSE
27	GTEx	Brain Cerebellar Hemisphere	RP1-228P16.1	0.30	0.21	lasso	7	0.28	6.5e-08	5.9	-5.9	3.4e-09	-0.04	0.31	0.68	FALSE
28	GTEx	Brain Cerebellar Hemisphere	RP4-605O3.4	0.18	0.12	enet	14	0.10	1.5e-03	9.9	8.2	2.6e-16	0.91	0.02	0.90	TRUE
29	GTEx	Brain Cortex	ASB8	0.28	0.19	lasso	7	0.20	3.3e-06	5.3	5.7	1.5e-08	0.04	0.09	0.88	FALSE
30	GTEx	Brain Frontal Cortex BA9	ASB8	0.24	0.16	lasso	6	0.07	7.1e-03	5.3	5.4	8.4e-08	0.03	0.25	0.32	FALSE
31	GTEx	Brain Nucleus accumbens basal ganglia	ASB8	0.20	0.04	lasso	4	0.02	7.7e-02	5.6	5.4	8.4e-08	0.07	0.06	0.61	FALSE
32	GTEx	Brain Putamen basal ganglia	RP1-228P16.1	0.21	0.24	lasso	6	0.24	2.1e-06	7.2	-6.6	3.9e-11	-0.07	0.01	0.98	FALSE
33	GTEx	Breast Mammary Tissue	RP1-228P16.1	0.22	0.14	lasso	8	0.20	1.3e-10	4.9	-6.0	2.0e-09	-0.07	0.18	0.82	FALSE
34	GTEx	Breast Mammary Tissue (Male)	RP1-228P16.1	0.13	0.00	lasso	6	0.01	1.8e-01	5.2	-5.9	3.5e-09	-0.05	0.06	0.42	FALSE
35	GTEx	Breast Mammary Tissue (Female)	ZNF641	0.04	0.01	lasso	1	-0.01	6.0e-01	5.2	5.2	2.1e-07	0.06	0.04	0.24	FALSE
36	GTEx	Breast Mammary Tissue (Female)	RP1-228P16.1	0.07	-0.01	enet	2	-0.01	5.9e-01	5.9	-6.0	1.8e-09	-0.07	0.04	0.38	FALSE
37	GTEx	Cells EBV-transformed lymphocytes	RP1-228P16.1	0.33	0.20	lasso	9	0.29	6.3e-10	5.7	-6.6	4.7e-11	-0.07	0.53	0.46	FALSE
38	GTEx	Cells Transformed fibroblasts	SMARCD1	0.08	0.07	enet	5	0.07	9.3e-06	6.3	-6.3	3.5e-10	-0.87	0.12	0.88	FALSE
39	GTEx	Cells Transformed fibroblasts	RP1-228P16.1	0.09	0.03	lasso	3	0.04	8.1e-04	5.7	-6.0	1.6e-09	-0.08	0.08	0.88	FALSE
40	GTEx	Colon Sigmoid	RP1-228P16.1	0.16	0.18	lasso	6	0.13	2.6e-05	4.9	-5.6	1.8e-08	-0.08	0.36	0.32	FALSE
41	GTEx	Colon Transverse	RP1-228P16.1	0.24	0.18	lasso	5	0.18	4.9e-09	5.6	-5.6	2.0e-08	-0.07	0.37	0.63	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	ATF1	0.15	0.15	lasso	4	0.14	7.8e-06	-5.7	-5.7	1.0e-08	-0.53	0.52	0.26	FALSE
43	GTEx	Esophagus Gastroesophageal Junction	RP1-228P16.1	0.23	0.25	enet	17	0.23	6.8e-09	5.6	-5.7	1.1e-08	-0.04	0.81	0.18	FALSE
44	GTEx	Esophagus Mucosa	ZNF641	0.08	0.00	enet	23	0.01	1.0e-01	7.2	5.4	5.7e-08	0.02	0.02	0.96	FALSE
45	GTEx	Esophagus Mucosa	RP1-228P16.1	0.19	0.18	lasso	4	0.21	8.7e-14	5.6	-5.8	6.4e-09	-0.06	0.95	0.05	FALSE
46	GTEx	Esophagus Muscularis	ATF1	0.15	0.17	lasso	2	0.16	7.5e-10	-5.6	-5.7	1.1e-08	-0.53	0.98	0.02	FALSE
47	GTEx	Esophagus Muscularis	TMBIM6	0.16	0.00	enet	19	0.06	1.7e-04	-2.5	7.2	7.2e-13	0.26	0.06	0.14	FALSE
48	GTEx	Esophagus Muscularis	RP1-228P16.1	0.20	0.17	enet	14	0.17	1.2e-10	5.6	-5.5	3.6e-08	-0.03	0.93	0.07	FALSE
49	GTEx	Heart Atrial Appendage	CERS5	0.14	0.03	lasso	6	0.02	4.2e-02	9.9	6.3	2.1e-10	0.87	0.04	0.93	FALSE
50	GTEx	Heart Atrial Appendage	RP1-228P16.1	0.16	0.02	enet	14	0.02	3.2e-02	5.2	-5.8	6.5e-09	-0.05	0.10	0.69	FALSE
51	GTEx	Heart Left Ventricle	RP1-228P16.1	0.26	0.14	lasso	16	0.17	1.9e-09	5.6	-6.0	1.5e-09	-0.03	0.20	0.80	FALSE
52	GTEx	Liver	RP1-228P16.1	0.19	0.08	lasso	7	0.06	7.1e-03	5.1	-5.2	2.0e-07	-0.07	0.16	0.31	FALSE
53	GTEx	Lung	ZNF641	0.08	0.10	lasso	2	0.08	8.0e-07	7.1	7.2	8.5e-13	0.08	0.01	0.99	FALSE
54	GTEx	Lung	RP1-228P16.1	0.18	0.20	enet	21	0.21	7.0e-16	5.6	-6.3	3.3e-10	-0.06	0.62	0.38	FALSE
55	GTEx	Muscle Skeletal	DIP2B	0.03	0.04	lasso	6	0.04	1.1e-04	-5.6	-5.6	2.6e-08	-0.53	0.79	0.12	FALSE
56	GTEx	Muscle Skeletal	ATF1	0.09	0.06	lasso	5	0.07	5.0e-07	-5.6	-6.2	4.1e-10	-0.60	0.18	0.82	FALSE
57	GTEx	Muscle Skeletal	RP1-228P16.1	0.12	0.10	lasso	9	0.09	7.4e-09	5.6	-5.6	1.9e-08	-0.04	0.96	0.04	FALSE
58	GTEx	Nerve Tibial	CERS5	0.31	0.28	enet	20	0.36	2.2e-26	9.9	7.8	7.5e-15	0.90	0.00	1.00	FALSE
59	GTEx	Nerve Tibial	ZNF641	0.14	0.11	lasso	4	0.08	2.3e-06	7.2	7.3	2.9e-13	0.08	0.00	1.00	FALSE
60	GTEx	Nerve Tibial	ASB8	0.09	0.08	lasso	4	0.07	1.8e-05	5.7	5.7	1.1e-08	0.04	0.70	0.15	FALSE
61	GTEx	Nerve Tibial	RP1-228P16.1	0.18	0.21	enet	22	0.21	4.9e-15	5.9	-5.8	4.8e-09	-0.05	0.99	0.01	FALSE
62	GTEx	Nerve Tibial	RP4-605O3.4	0.11	0.00	lasso	3	0.00	1.7e-01	9.9	9.8	9.9e-23	0.83	0.01	0.93	FALSE
63	GTEx	Pancreas	RP1-228P16.1	0.12	0.05	enet	10	0.05	5.0e-03	4.2	-5.7	1.2e-08	-0.03	0.35	0.18	FALSE
64	GTEx	Pituitary	RP1-228P16.1	0.20	0.15	lasso	6	0.16	1.1e-04	5.6	-6.6	3.2e-11	-0.07	0.04	0.90	FALSE
65	GTEx	Prostate	CERS5	0.19	0.08	lasso	4	0.02	1.2e-01	9.9	9.5	3.1e-21	0.97	0.02	0.75	FALSE
66	GTEx	Skin Not Sun Exposed Suprapubic	ZNF641	0.15	0.11	enet	30	0.10	3.1e-06	7.2	6.7	1.7e-11	0.08	0.01	0.99	FALSE
67	GTEx	Skin Not Sun Exposed Suprapubic	RP1-228P16.1	0.17	0.10	enet	23	0.16	4.1e-09	6.6	-7.0	1.8e-12	-0.03	0.08	0.92	FALSE
68	GTEx	Skin Sun Exposed Lower leg	SMARCD1	0.07	0.02	lasso	2	0.03	1.4e-03	-8.9	-9.6	6.0e-22	-0.69	0.06	0.80	FALSE
69	GTEx	Skin Sun Exposed Lower leg	ZNF641	0.21	0.03	enet	17	0.08	6.5e-07	-1.6	5.8	8.7e-09	0.08	0.06	0.94	FALSE
70	GTEx	Skin Sun Exposed Lower leg	RP1-228P16.1	0.29	0.24	enet	28	0.26	2.0e-21	5.7	-6.4	1.6e-10	-0.04	0.99	0.01	FALSE
71	GTEx	Spleen	ZNF641	0.42	0.21	lasso	11	0.28	5.4e-08	-2.2	5.4	6.9e-08	0.08	0.03	0.95	FALSE
72	GTEx	Spleen	RP1-228P16.1	0.35	0.23	lasso	7	0.19	1.6e-05	5.9	-6.0	2.0e-09	-0.04	0.37	0.55	FALSE
73	GTEx	Stomach	RP1-228P16.1	0.12	0.03	lasso	7	0.05	1.9e-03	5.6	-5.8	8.3e-09	-0.03	0.31	0.63	FALSE
74	GTEx	Testis	SMARCD1	0.22	0.10	enet	22	0.10	2.6e-05	6.7	-8.4	5.3e-17	-0.85	0.01	0.98	FALSE
75	GTEx	Testis	SENP1	0.20	0.13	lasso	5	0.10	2.7e-05	4.9	5.3	1.3e-07	0.10	0.75	0.06	FALSE
76	GTEx	Testis	CERS5	0.12	0.06	lasso	6	0.07	4.0e-04	9.9	10.0	1.3e-23	0.98	0.01	0.94	TRUE
77	GTEx	Testis	ASB8	0.17	0.15	lasso	3	0.13	1.8e-06	4.8	5.4	6.3e-08	0.06	0.48	0.32	FALSE
78	GTEx	Testis	RP1-228P16.1	0.38	0.28	lasso	6	0.31	4.0e-14	5.9	-7.0	2.4e-12	-0.07	0.97	0.03	FALSE
79	GTEx	Thyroid	LIMA1	0.08	0.06	enet	18	0.06	1.7e-05	9.2	7.8	6.9e-15	0.68	0.15	0.56	TRUE
80	GTEx	Thyroid	ZNF641	0.16	0.06	enet	26	0.13	2.0e-10	-3.5	5.8	9.0e-09	0.08	0.07	0.93	FALSE
81	GTEx	Thyroid	ASB8	0.09	0.00	enet	34	0.01	2.8e-02	5.6	6.3	2.7e-10	0.10	0.43	0.36	FALSE
82	GTEx	Thyroid	RP1-228P16.1	0.30	0.30	enet	41	0.33	1.4e-25	5.7	-6.2	6.0e-10	-0.06	0.99	0.01	FALSE
83	GTEx	Vagina	ZNF641	0.23	-0.01	enet	39	0.01	2.2e-01	-4.6	5.2	1.9e-07	0.07	0.03	0.66	FALSE
84	GTEx	Whole Blood	ATF1	0.07	0.09	lasso	4	0.07	3.5e-07	5.2	5.3	1.4e-07	0.46	1.00	0.00	TRUE
85	GTEx	Whole Blood	RP1-228P16.1	0.10	0.06	enet	20	0.09	4.7e-09	4.9	-5.7	1.2e-08	-0.04	0.56	0.43	FALSE
86	GTEx	Whole Blood	RP4-605O3.4	0.04	0.04	lasso	4	0.01	1.5e-02	9.9	9.7	3.2e-22	0.99	0.01	0.97	FALSE
87	METSIM	Adipose	ASB8	0.03	0.00	bslmm	526	0.01	3.8e-02	5.9	6.2	5.8e-10	0.01	0.17	0.10	FALSE
88	METSIM	Adipose	DIP2B	0.04	0.00	enet	16	0.01	4.6e-03	-5.1	5.1	2.9e-07	0.19	0.25	0.03	FALSE
89	METSIM	Adipose	PFKM	0.05	0.01	bslmm	525	0.02	7.3e-04	4.8	-5.1	2.7e-07	-0.01	0.17	0.66	FALSE
90	METSIM	Adipose	ZNF641	0.07	0.03	blup	487	0.06	7.0e-09	-4.6	5.8	4.8e-09	0.06	0.03	0.97	FALSE
91	NTR	Blood	ATF1	0.06	0.07	enet	35	0.07	4.0e-21	7.0	6.7	1.6e-11	0.63	1.00	0.00	FALSE
92	NTR	Blood	FMNL3	0.02	0.02	lasso	3	0.01	1.3e-05	-5.3	5.2	1.5e-07	-0.01	0.97	0.00	FALSE
93	YFS	Blood	ATF1	0.05	0.07	lasso	9	0.07	2.0e-21	7.1	7.6	3.0e-14	0.69	0.99	0.01	FALSE
94	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMARCD1	0.02	0.03	lasso	1	0.03	3.7e-06	6.1	-6.2	7.8e-10	-0.87	0.15	0.81	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HDAC7	0.05	0.02	blup	85	0.01	7.5e-03	-5.8	-7.5	9.7e-14	-0.06	0.10	0.33	TRUE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB8	0.04	0.03	blup	69	0.03	4.1e-04	6.6	5.4	5.8e-08	0.04	0.01	0.98	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIMA1	0.08	0.10	blup	59	0.10	1.8e-11	9.2	-9.0	1.9e-19	-0.90	0.35	0.65	FALSE
98	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF641	0.09	0.01	blup	50	0.06	7.1e-07	-1.7	5.8	6.2e-09	0.07	0.02	0.85	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB8	0.08	0.01	blup	69	0.04	3.9e-05	5.3	5.4	7.8e-08	0.07	0.14	0.74	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	ATF1	0.03	0.04	lasso	1	0.04	6.3e-05	7.1	-7.1	1.5e-12	-0.62	0.04	0.94	FALSE
101	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AQP5	0.14	0.07	lasso	1	0.05	1.5e-04	6.3	-6.3	3.2e-10	-0.28	0.00	1.00	FALSE
102	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AQP6	0.09	0.05	enet	17	0.04	1.8e-03	6.3	-6.6	3.4e-11	-0.25	0.00	0.99	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	AQP5	0.06	0.04	lasso	2	0.03	8.9e-04	6.3	-6.2	4.9e-10	-0.28	0.00	0.98	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	AQP5	0.12	0.04	enet	19	0.03	2.6e-04	6.0	-5.6	2.2e-08	-0.24	0.00	0.98	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	AQP6	0.07	0.04	blup	43	0.03	7.4e-04	6.3	-6.2	6.4e-10	-0.31	0.00	0.98	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	ASB8	0.04	0.03	lasso	3	0.03	2.3e-04	5.3	5.3	9.8e-08	0.02	0.24	0.59	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf62	0.06	0.02	blup	47	0.05	1.8e-05	-1.9	-5.3	1.2e-07	-0.82	0.04	0.95	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	DIP2B	0.12	0.18	lasso	3	0.18	9.2e-18	-5.5	5.4	6.7e-08	0.20	1.00	0.00	TRUE
109	The Cancer Genome Atlas	Thyroid Carcinoma	FMNL3	0.07	0.08	lasso	2	0.08	7.5e-08	-5.7	6.1	1.4e-09	-0.07	0.01	0.99	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	OR10AD1	0.06	0.03	lasso	3	0.05	7.6e-06	-3.0	5.5	4.9e-08	0.10	0.05	0.85	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	VDR	0.06	0.03	enet	18	0.03	3.1e-04	-2.9	-5.6	1.8e-08	-0.05	0.14	0.17	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF641	0.11	0.12	enet	10	0.12	5.2e-12	7.0	6.8	1.0e-11	0.06	0.02	0.98	FALSE