TWAS hub - AQP5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0440	4.3e-03	0.061	0.000	0.032	0.025	0.039	6.5e-08	0.28000	7.2e-05	0.00046	1.4e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0393	0.0189	2.0e-03	0.031	0.016	0.004	NA	0.013	1.8e-04	0.00600	1.2e-01	NA	1.2e-02
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.1370	0.0520	4.6e-04	0.070	0.043	0.049	NA	0.054	1.7e-05	0.00071	3.1e-04	NA	1.5e-04
4	TCGA	Prostate Adenocarcinoma	0.0577	0.0295	7.7e-03	0.037	0.004	0.013	NA	0.026	9.1e-05	0.11000	1.3e-02	NA	8.9e-04
5	TCGA	Thyroid Carcinoma	0.1250	0.0400	1.1e-05	0.042	0.028	0.034	NA	0.027	6.1e-05	0.00085	2.6e-04	NA	1.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Allergy or Eczema	7.0	18.3	35.2	-3.7	-5.9	-4.3	-4.3	-2.4
Systolic Blood Pressure	6.4	32.2	39.6	-6.0	-3.9	-6.3	-6.2	-5.6
Diastolic blood pressure, automated reading	6.1	18.8	23.5	-4.4	-2.6	-4.8	-4.7	-4.7
Hayfever, allergic rhinitis or eczema	6.0	12.9	33.8	-2.2	-5.8	-3.5	-3.5	-1.3
Ever had prostate specific antigen (PSA) test	5.9	6.8	10.9	2.5	1.2	3.2	3.3	2.4
Allergy	5.3	12.2	28.5	2.3	5.3	3.6	3.6	1.2
High blood pressure	4.4	12.3	19.0	-3.6	-0.6	-3.8	-3.8	-4.4
Age at First Birth	4.3	6.3	15.9	-2.1	-4.0	-2.1	-2.1	-1.5
Alzheimer’s Disease (in father)	4.2	4.6	6.1	2.4	1.2	2.5	2.5	1.9
Systolic blood pressure, automated reading	4.2	12.3	16.1	-3.6	-1.8	-4.0	-3.9	-3.7
High blood pressure (mother)	4.0	5.6	7.4	-2.7	-1.2	-2.6	-2.6	-2.3
Illnesses of father: High blood pressure	4.0	5.0	8.8	-1.9	-0.3	-2.6	-2.4	-3.0
High blood pressure (siblings)	3.8	5.5	13.5	-1.3	-3.7	-2.1	-2.1	-1.9
Hypertension (Self-reported)	3.8	10.5	15.6	-3.2	-1.2	-3.6	-3.5	-4.0
Vascular/heart problems diagnosed by doctor	3.7	10.2	14.9	3.4	0.7	3.5	3.4	3.9
Number of incorrect matches in round	3.6	6.1	7.8	2.8	0.5	2.8	2.8	2.6
Asthma (self-reported)	3.6	7.1	9.2	-2.3	-2.9	-3.0	-3.0	-1.9
Prospective memory result	3.4	4.2	6.4	2.5	1.2	2.2	2.2	1.8
Serious illness, injury or assault to yourself	3.3	3.9	4.8	2.0	1.3	2.1	2.1	2.2
Cardiovascular Disease	3.2	10.5	13.3	-3.7	-1.6	-3.5	-3.6	-3.4
Asthma	3.2	6.3	8.4	-2.0	-2.8	-2.9	-2.8	-1.7
Emphysema/chronic bronchitis	2.9	3.3	6.2	2.5	0.4	1.8	1.8	1.8
Eye problems/disorders: Cataract	2.9	3.4	5.8	1.6	1.1	2.4	2.4	1.2
Alcohol drinker status: Previous	2.9	3.3	6.8	-2.2	-0.1	-1.5	-1.6	-2.6
Respiratory disease	2.8	6.3	8.5	-2.1	-2.1	-2.9	-2.8	-2.4
Financial difficulties in last 2 years	2.8	3.7	7.2	-1.7	-1.4	-2.6	-2.7	-0.2
Handedness (chirality/laterality): Left-handed	2.8	3.3	4.3	-2.0	-1.9	-2.0	-2.1	-0.6
Average weekly champagne plus white wine intake	2.6	3.5	5.6	1.6	1.6	1.9	1.8	2.4
Medication: Ramipril	2.5	3.2	5.5	-1.8	-1.4	-1.6	-1.6	-2.4
Medication: Amlodipine	2.5	3.5	4.8	-1.1	-1.7	-2.1	-2.1	-2.2
Pain type(s) experienced in last month: Hip pain	2.5	3.2	9.9	1.4	3.1	1.3	1.3	0.8
Falls in the last year	2.4	3.2	4.8	1.6	1.9	2.1	2.2	0.8
Number of live births	2.4	3.4	10.6	1.1	3.3	1.2	1.2	1.5
Medication: Blood pressure	2.4	4.6	6.6	-2.0	-0.8	-2.6	-2.6	-2.3
Illnesses of siblings	2.3	3.3	4.3	1.7	1.8	1.8	1.7	2.1
Smoking status: Previous	2.3	3.5	5.5	-2.3	-1.2	-1.6	-1.6	-2.3
Number of self-reported non-cancer illnesses	2.3	3.9	5.4	-1.9	-1.0	-2.3	-2.3	-2.0
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	6.6	-1.5	-2.6	-1.7	-1.8	-0.1
Medication: Blood pressure	2.2	3.8	4.6	-2.1	-1.3	-2.1	-2.1	-2.0
Severe depression (siblings)	2.1	2.3	3.1	1.4	1.6	1.7	1.8	1.1
Alcohol usually taken with meals	2.0	3.2	4.9	1.6	0.9	2.0	1.9	2.2
Pulse wave reflection index	1.9	2.3	3.9	-1.3	-1.1	-1.6	-1.5	-2.0
Number of treatments/medications taken	1.8	3.3	5.0	-1.8	0.1	-2.1	-2.0	-2.2
Birth weight of first child	1.8	3.2	5.1	1.0	1.0	2.2	2.1	2.2
Medication for cholesterol	1.8	2.8	4.0	1.6	0.4	2.0	2.0	1.8
Medication: Bendroflumethiazide	1.8	2.7	3.7	-1.7	-1.3	-1.9	-1.9	-1.2
Average weekly beer plus cider intake	1.8	2.6	4.1	-1.3	-1.4	-2.0	-2.0	-1.2
Lung FEV1/FVC ratio	1.7	8.8	21.3	1.7	4.6	2.7	2.7	2.3
Illnesses of mother	1.7	2.1	4.2	1.4	-0.2	1.4	1.4	2.1
Irritable Bowel Disease (IBD)	1.6	3.9	5.6	1.6	2.4	2.0	1.9	1.9
Medication: Aspirin	1.6	2.1	3.5	-1.4	-0.6	-1.5	-1.6	-1.9
Pack years of smoking	1.6	2.3	4.4	2.1	1.3	1.6	1.6	0.3
Trunk fat percentage	1.5	6.0	9.3	-2.2	-0.5	-3.0	-3.0	-2.6
Medication: Simvastatin	1.5	2.2	2.8	-1.7	-1.3	-1.6	-1.6	-1.3
Hair/balding pattern: Pattern 3	1.5	2.2	6.0	1.0	-1.5	1.0	0.9	2.4
Lung cancer (father)	1.5	1.7	2.5	-1.6	1.1	-1.2	-1.1	-1.5
Hair/balding pattern: Pattern 4	1.5	3.6	7.0	1.5	2.6	1.9	2.0	1.0
Worry too long after embarrassment	1.5	2.5	3.6	1.9	-0.2	1.8	1.9	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	2.9	-1.7	1.1	-1.3	-1.2	-1.2
Myopia	1.5	2.2	4.4	-1.0	-2.1	-1.4	-1.3	-1.4
Ulcerative Colitis (UC)	1.4	2.7	4.8	1.3	2.2	1.7	1.6	1.1
Impedance of leg (right)	1.4	6.7	18.2	-1.6	-4.3	-2.4	-2.3	-1.3
Happiness	1.4	1.7	2.4	1.1	-1.2	1.3	1.4	1.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.5	-1.6	-1.0	-1.4	-1.3	-1.3
Comparative body size at age 10	1.4	4.0	10.8	0.4	3.0	0.3	0.2	3.3
Medication: Aspirin	1.4	1.8	3.8	-1.3	-0.4	-1.2	-1.3	-1.9
Medication: Gliclazide	1.4	1.5	3.1	1.3	1.8	1.0	1.0	0.9
Alzheimer’s Disease (including proxy)	1.3	1.8	3.4	1.4	0.5	1.8	1.8	0.6
Townsend deprivation index at recruitment	1.3	1.8	2.8	1.4	0.1	1.4	1.4	1.7
Chronic bronchitis/emphysema (father)	1.3	1.5	3.0	1.1	1.7	1.1	1.1	0.8
Trunk fat mass	1.3	5.5	9.2	-2.4	-0.2	-2.9	-3.0	-2.1
Qualifications: None of the above	1.3	2.8	11.3	0.5	3.4	1.2	1.1	0.1
Blood clot in the leg (DVT)	1.3	1.7	2.9	0.9	1.5	1.1	1.1	1.7
Gout (self-reported)	1.3	1.8	2.7	-1.5	-0.5	-1.6	-1.6	-1.1
Body fat percentage	1.3	5.0	7.9	-2.2	-0.1	-2.7	-2.8	-2.3
Fractured/broken bones in last 5 years	1.3	1.7	3.3	-1.2	-1.8	-1.2	-1.3	-0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.9	1.4	1.3	1.1	1.0	1.7
Past tobacco smoking	1.2	2.3	3.0	1.7	1.7	1.2	1.2	1.6
Pain all over the body in last month	1.2	1.3	2.3	1.1	1.2	0.9	0.8	1.5
Father’s age at death	1.2	1.6	2.2	1.5	-1.0	1.2	1.2	1.5
Mouth/teeth dental problems: Dentures	1.2	2.1	3.6	1.2	1.5	1.8	1.9	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	6.4	-0.7	0.3	-0.4	-0.2	-2.5
Medication: Allopurinol	1.2	1.6	2.5	-1.6	-0.3	-1.6	-1.5	-0.8
Medication: Seretide 50 evohaler	1.2	1.4	2.4	1.5	0.8	1.0	0.9	1.6
Whole body fat mass	1.2	4.8	8.0	-2.3	0.1	-2.7	-2.8	-1.9
Leg pain on walking	1.2	1.5	2.6	1.4	0.9	1.5	1.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.9	0.9	1.7	0.9	1.0	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	3.5	-1.9	-0.2	-1.7	-1.6	-1.8
Heart attack	1.1	1.5	2.4	1.3	1.1	1.0	1.0	1.6
Arm fat percentage (right)	1.1	4.3	6.8	-1.9	0.0	-2.5	-2.6	-2.2
Birth weight	1.1	2.4	5.5	1.7	-0.9	1.3	1.1	2.4
Leg fat mass (right)	1.1	4.4	6.9	-2.4	0.6	-2.5	-2.6	-1.6
Ever had bowel cancer screening	1.1	1.3	2.2	1.2	0.1	1.4	1.5	0.9
Mother’s age at death	1.1	1.4	2.0	-0.9	-1.2	-1.4	-1.3	-1.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	4.3	0.7	2.1	0.7	0.8	0.7
Pack years adult smoking proportion	1.0	1.6	2.8	1.7	1.5	1.2	1.2	-0.3
Multivitamins +/- minerals	1.0	1.3	2.9	-1.7	-0.8	-1.1	-1.1	-0.9
Hip circumference	1.0	4.3	7.4	-2.1	-0.5	-2.6	-2.7	-1.6
Depression (self-reported)	1.0	1.2	3.9	0.8	0.7	0.6	0.6	2.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	1.9	1.3	1.3	1.3	1.3	1.4
Leg fat percentage (right)	1.0	3.6	5.5	-2.1	0.4	-2.2	-2.3	-1.8
Arm fat percentage (left)	1.0	3.9	5.9	-1.9	0.3	-2.3	-2.4	-2.2
Average weekly red wine intake	1.0	1.4	1.9	-1.4	0.1	-1.4	-1.3	-1.3
Mean Putamen Volume	0.9	1.0	3.1	-0.8	-1.7	-1.1	0.0	-0.1
Fasting Glucose	0.9	1.1	2.6	1.1	1.6	0.7	0.7	0.8
Rheumatoid Arthritis	0.9	1.2	1.9	1.2	1.4	1.1	0.0	1.2
Average weekly spirits intake	0.9	1.2	5.0	-0.6	0.5	-0.4	-0.3	-2.2
Arm fat mass (right)	0.9	3.7	5.9	-2.0	0.2	-2.3	-2.4	-1.7
Neck or shoulder pain in last month	0.9	1.3	1.7	-1.1	-0.6	-1.3	-1.3	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	1.6	1.0	1.3	1.1	1.2	0.4
Diabetes diagnosed by doctor	0.9	1.5	4.2	-0.3	2.1	-0.8	-0.8	-1.3
Mineral and other dietary supplements	0.9	1.1	1.7	1.3	0.8	1.3	1.3	0.2
Breast cancer (self-reported)	0.9	1.0	3.3	-1.1	1.8	-0.4	-0.4	-0.6
Commuting to job workplace: Public transport	0.9	1.1	3.0	0.8	-0.1	1.0	0.9	1.7
Unable to work because of sickness or disability	0.9	1.2	4.4	0.4	2.1	0.7	0.7	0.7
Basal cell carcinoma (self-reported)	0.9	1.0	2.8	-1.7	0.9	-0.8	-0.9	0.2
Leg fat mass (left)	0.9	3.7	6.1	-2.1	0.7	-2.3	-2.5	-1.4
Depressed Affect (Nagel 2018)	0.8	1.8	3.7	1.1	1.9	1.2	1.2	1.1
Alzheimer’s Disease (in mother)	0.8	0.9	1.9	1.4	0.3	1.1	1.1	0.1
Medication for hormone replacement therapy	0.8	0.9	1.3	-0.8	0.7	-0.9	-1.0	-1.1
Medication: Co-codamol	0.8	0.9	2.3	1.0	1.5	0.7	0.8	0.1
Diabetes (mother)	0.8	1.1	2.3	0.6	1.5	0.8	0.8	1.2
Impedance of leg (left)	0.8	3.9	12.6	-0.7	-3.5	-1.7	-1.7	-0.8
Number of children fathered	0.8	0.9	3.0	-0.7	1.7	-0.4	-0.4	-0.8
Age at first live birth	0.8	1.5	6.2	0.2	-2.5	-0.6	-0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.7	0.6	0.6	1.1	1.1	1.3
Arm fat mass (left)	0.8	3.4	5.7	-1.9	0.1	-2.2	-2.4	-1.6
High cholesterol (Self-reported)	0.8	1.3	1.7	-1.3	-1.3	-1.2	-1.2	-0.8
Neuroticism (Nagel 2018)	0.7	1.6	2.1	1.3	1.4	1.3	1.4	0.8
Crohns Disease (2017)	0.7	1.6	2.9	0.8	1.7	1.1	1.0	1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	6.4	-0.1	2.5	-0.1	-0.2	-0.4
Relative age of first facial hair	0.7	1.4	2.7	1.6	-0.8	1.3	1.4	0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.6	0.4	0.9	0.4	0.5	-1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.0	-1.4	0.0	-1.3	-1.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.7	0.7	1.3	0.9	1.0	1.1
Worrier / anxious feelings	0.7	1.3	2.3	-1.0	-0.1	-1.5	-1.3	-1.2
Medication: Lansoprazole	0.7	0.8	4.0	-0.1	2.0	0.1	0.2	0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.0	-0.7	0.3	-1.4	-1.4	-0.5
Migraine (self-reported)	0.7	0.8	3.0	0.7	1.7	0.5	0.7	0.2
Loneliness, isolation	0.7	1.0	1.8	-0.2	1.3	1.0	1.0	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.0	1.0	-0.3	1.0	1.0	1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.7	1.3	0.8	0.9	1.0	0.1
Medication: Lisinopril	0.7	0.9	1.4	-1.2	0.6	-0.9	-1.0	-1.0
Bipolar Disorder (2018)	0.6	1.0	4.9	-0.3	-2.2	-0.2	0.0	0.0
Ulcerative Colitis	0.6	0.8	2.8	0.8	1.7	0.9	0.0	0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.0	-0.9	-0.1	-0.9	-1.0	-0.8
Medication: Metformin	0.6	0.8	2.9	1.1	1.7	0.2	0.1	0.2
Supplements: Glucosamine	0.6	0.8	2.3	-0.7	-1.5	-0.6	-0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	1.2	0.4	1.0	0.9	0.1
Body mass index (BMI)	0.6	2.4	2.7	-1.6	1.5	-1.5	-1.6	-1.5
Diabetes (self-reported)	0.6	1.0	3.6	0.2	1.9	-0.4	-0.4	-0.8
Weight	0.6	3.2	5.8	-2.0	0.0	-2.3	-2.4	-1.0
Headache pain in last month	0.6	1.1	1.2	-1.1	-0.9	-1.1	-1.1	-1.0
Heart disease (mother)	0.6	0.7	1.5	-0.8	-0.7	-0.8	-0.8	-1.2
Supplements: Vitamin C	0.6	0.7	1.5	0.8	1.2	0.8	0.6	0.6
Commuting to job workplace: Walk	0.6	0.7	2.6	0.2	0.0	-0.6	-0.7	1.6
Osteoarthritis (self-reported)	0.6	0.8	1.9	0.8	1.4	0.8	0.9	0.4
Hearing aid user	0.6	0.6	1.4	-1.2	0.4	-0.6	-0.6	-1.0
Leg fat percentage (left)	0.6	2.3	3.6	-1.6	0.8	-1.8	-1.9	-1.4
Impedance of whole body	0.6	3.0	10.2	-0.2	-3.2	-1.4	-1.3	-1.0
Depression (Nagel 2018)	0.5	0.7	1.4	0.7	1.2	0.8	0.8	0.7
Intelligence (Savage-Jansen 2018)	0.5	1.5	4.4	-0.4	0.8	-1.1	-1.0	-2.1
Primary Biliary Cirrhosis	0.5	0.7	1.2	-0.5	-1.1	-0.8	0.0	-1.1
Maternal smoking around birth	0.5	0.7	1.3	-0.5	-1.2	-0.6	-0.7	1.1
Fed-up feelings	0.5	1.0	2.0	0.9	1.4	0.7	0.7	1.1
Relative age voice broke	0.5	0.8	3.6	0.4	-1.9	0.0	0.1	0.2
Medication: Atenolol	0.5	0.6	1.1	1.0	0.4	1.0	1.0	-0.3
Impedance of arm (right)	0.5	2.2	8.9	0.2	-3.0	-0.9	-0.9	-0.7
Exposure to tobacco smoke at home	0.5	0.5	0.9	0.3	0.8	1.0	0.9	0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.8	0.7	1.3	0.4	0.4	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.3	-0.5	-1.5	-0.7	-0.8	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.8	-0.8	0.6	-0.8	-0.9	-0.6
Health satisfaction	0.5	0.7	1.4	0.5	1.2	0.8	0.8	-0.6
Had major operations	0.5	0.6	2.0	-0.7	-1.4	-0.5	-0.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.5	0.0	1.6	0.1	0.1	0.3
Qualifications: nursing, teaching	0.5	0.8	3.2	0.3	-1.8	0.4	0.4	0.7
Osteoporosis (self-reported)	0.5	0.6	1.4	-0.4	-0.4	-1.1	-1.2	0.1
Smoking status: Current	0.5	0.8	2.0	1.4	0.2	0.9	0.9	0.6
Ever taken oral contraceptive pill	0.5	0.6	1.4	-0.3	0.2	-1.1	-1.2	-0.6
Eye problems/disorders: Glaucoma	0.5	0.6	2.0	-0.1	-1.4	-0.6	-0.6	-0.5
Alcohol drinker status: Never	0.5	0.6	1.1	0.5	0.6	1.1	1.1	-0.0
Ever smoked	0.5	0.8	2.6	-0.6	-1.6	-0.4	-0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.9	0.1	1.7	0.1	0.2	-0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-1.1	0.0	-1.1	0.0	0.0
Ovarian Cancer	0.4	0.6	2.1	-0.0	-1.4	-0.6	-0.5	0.0
Bipolar Disorder (2011)	0.4	0.4	1.3	-1.2	0.0	-0.9	0.0	0.0
Neuroticism (2016)	0.4	0.5	1.0	-0.8	-0.8	-1.0	0.0	0.5
Blood Platelet Count	0.4	4.9	7.0	1.8	2.3	2.6	2.6	1.5
Hearing difficulty/problems: Yes	0.4	0.6	1.5	0.5	0.1	1.2	1.2	0.1
Average weekly fortified wine intake	0.4	0.5	0.9	-0.3	-0.8	-0.9	-0.9	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.6	-0.6	-0.5	-0.8	-0.8	0.4
Sitting height	0.4	2.9	7.0	-1.0	-2.6	-1.8	-1.8	-0.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	0.1	-1.0	-0.3	-0.3	-1.0
Had other major operations	0.4	0.5	0.5	-0.7	0.6	-0.7	-0.7	-0.7
Forced vital capacity (FVC)	0.4	1.5	2.8	-0.7	-1.7	-1.4	-1.3	-0.5
Noisy workplace	0.4	0.4	1.7	-0.6	1.3	0.0	-0.0	-0.5
Impedance of arm (left)	0.4	2.1	7.8	0.1	-2.8	-1.0	-0.9	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.8	0.9	0.5	0.8	0.8	0.7
Medication: Omeprazole	0.4	0.4	2.1	0.2	1.5	0.1	0.1	0.0
Overall health rating	0.4	0.9	1.8	-0.6	0.4	-1.1	-1.1	-1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.9	-0.2	-1.0	0.6	0.6	-0.7
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.1	-1.1	0.0	-0.9	-0.9	-0.1
Irritability	0.4	0.7	2.0	-0.5	0.5	-0.7	-0.7	-1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.0	0.3	1.4	0.2	0.3	-1.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-1.0	0.2	-1.1	0.0	-0.2
Coronary Artery Disease (CAD)	0.3	0.3	0.9	0.9	0.0	0.8	0.0	0.0
LDL Cholesterol	0.3	0.5	2.2	0.5	0.1	1.5	0.0	0.0
Blood White Count	0.3	2.4	6.5	1.0	2.5	1.5	1.5	0.5
Heel T-Score	0.3	2.3	3.5	-1.9	-1.6	-1.5	-1.5	-0.9
BMI	0.3	1.9	2.7	-1.6	1.6	-1.4	-1.6	-0.1
Lung FVC	0.3	1.6	2.9	1.7	-0.1	1.5	1.6	0.2
Neuroticism	0.3	0.8	1.1	1.1	0.8	0.9	1.0	0.6
Hand grip strength (left)	0.3	0.7	1.6	0.8	-1.1	0.2	0.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-0.2	1.2	0.3	0.4	-0.2
Current tobacco smoking	0.3	0.5	1.4	1.2	0.5	0.7	0.7	-0.1
Leg predicted mass (left)	0.3	1.4	2.4	-1.5	0.7	-1.4	-1.6	-0.1
Waist circumference	0.3	1.2	1.8	-1.1	1.0	-1.2	-1.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.4	-0.7	-0.1	-0.1	-1.1
Pulse rate	0.3	0.5	1.0	-0.8	-1.0	-0.6	-0.7	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.8	-0.3	-1.7	0.2	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.7	0.1	-1.3	-0.2	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	0.1	-1.0	0.6	0.5	0.6
Medication: Cholesterol lowering	0.3	0.5	1.2	-1.1	-0.6	-0.4	-0.4	-0.9
Standing height	0.3	3.2	7.9	-1.1	-2.8	-1.6	-1.7	1.1
Length of working week for main job	0.3	0.3	0.5	0.3	-0.4	0.7	0.6	0.7
Loud music exposure frequency	0.3	0.3	1.2	-0.5	-1.1	-0.2	-0.2	0.1
Medication: Paracetamol	0.3	0.5	2.2	-0.4	1.5	-0.4	-0.4	-0.1
Arm fat-free mass (right)	0.3	1.5	3.2	-1.8	0.2	-1.4	-1.5	0.2
Exposure to tobacco smoke outside home	0.3	0.5	2.0	0.2	1.4	0.4	0.3	-0.1
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-0.4	-0.0	-1.0	-0.9	-0.8
Qualifications: College or University degree	0.3	0.8	1.9	0.5	-1.4	0.5	0.6	1.2
Eye problems/disorders: None of the above	0.3	0.4	0.9	-0.3	-0.1	-0.9	-1.0	-0.4
Angina (self-reported)	0.3	0.4	0.4	0.6	0.7	0.6	0.6	-0.4
Arm predicted mass (right)	0.3	1.5	3.1	-1.8	0.3	-1.4	-1.5	0.1
Suffer from ‘nerves’	0.3	0.5	1.0	0.5	-0.6	0.9	1.0	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	-0.5	-0.0	-0.8	-0.9	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	-0.0	0.7	0.4	0.4	-1.0
Illnesses of father: Heart disease	0.3	0.4	1.8	-0.2	0.1	-0.2	-0.2	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	0.4	0.0	0.8	0.9	0.8
Miserableness	0.3	0.5	1.4	0.6	0.2	0.5	0.6	1.2
Basal metabolic rate	0.3	1.5	2.7	-1.6	0.2	-1.5	-1.7	0.1
Number of operations (self-reported)	0.3	0.4	1.2	-0.8	-1.1	-0.3	-0.3	-0.1
Risk taking	0.3	0.4	1.1	1.0	-0.0	0.8	0.7	-0.1
Commuting to job workplace: Cycle	0.3	0.4	0.9	-0.6	-0.9	-0.6	-0.6	0.2
Arm predicted mass (left)	0.3	1.6	2.8	-1.7	-0.1	-1.5	-1.7	0.4
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	-0.6	-1.2	-0.5	0.0	0.0
Major Depression (MDD)	0.2	0.2	0.4	-0.6	0.6	-0.4	0.0	0.0
Reaction Time	0.2	0.3	1.4	0.3	1.2	-0.0	0.0	0.1
HbA1C	0.2	0.2	0.4	0.3	0.5	0.5	0.7	-0.3
Schizophrenia (2014)	0.2	0.4	1.2	-0.7	-0.4	-1.1	0.0	0.0
Triglycerides	0.2	0.3	0.6	0.6	0.8	0.6	0.0	0.0
Height	0.2	4.0	11.1	-1.0	-3.3	-2.0	-2.0	0.2
Waist Hip Ratio (WHR)	0.2	1.0	1.7	0.4	1.3	1.3	1.3	0.5
Tanning	0.2	3.0	4.8	-2.1	-0.1	-2.1	-2.2	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.6	-0.4
Angina	0.2	0.2	0.6	0.3	0.6	0.3	0.2	-0.8
Vitamin and mineral supplements	0.2	0.2	0.6	0.8	0.4	0.3	0.4	0.5
Leg fat-free mass (left)	0.2	1.2	2.1	-1.4	0.7	-1.3	-1.4	-0.0
Hand grip strength (right)	0.2	0.5	1.4	0.3	-1.2	-0.1	-0.1	1.1
Qualifications: CSEs or equivalent	0.2	0.2	0.6	0.1	0.2	-0.7	-0.7	0.1
Hearing difficulty/problems with background noise	0.2	0.3	0.4	0.5	-0.3	0.7	0.6	0.6
Had menopause	0.2	0.2	0.5	0.1	0.2	0.6	0.7	0.2
Fluid intelligence score	0.2	0.5	0.7	0.8	0.8	0.6	0.7	-0.5
Time employed in main current job	0.2	0.2	0.5	0.6	0.7	0.3	0.3	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.9	-0.5	0.9	-0.6	-0.6	-0.4
Breastfed as a baby	0.2	0.3	0.4	-0.6	0.0	-0.5	-0.5	-0.6
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.5	-0.9	-0.7	-0.7	-0.4
Glaucoma (self-reported)	0.2	0.3	0.7	0.7	-0.9	-0.2	-0.2	0.3
Pulse wave peak to peak time	0.2	0.2	1.1	-0.1	-1.0	0.1	0.1	-0.0
Shortness of breath walking on level ground	0.2	0.2	0.5	0.1	0.0	-0.5	-0.5	-0.7
Medication: Ibuprofen	0.2	0.2	0.7	0.1	-0.9	0.5	0.5	0.1
Mean time to correctly identify matches	0.2	0.4	0.7	0.6	0.8	0.8	0.8	0.0
Comparative height size at age 10	0.2	0.8	1.3	-0.9	-0.9	-0.7	-0.8	1.2
Knee pain experienced in last month	0.2	0.4	1.4	0.2	1.2	-0.5	-0.5	-0.1
Whole body fat-free mass	0.2	0.9	1.7	-1.3	0.2	-1.0	-1.1	0.7
Long-standing illness, disability or infirmity	0.2	0.4	0.7	-0.1	0.5	-0.8	-0.8	-0.6
Friendships satisfaction	0.2	0.3	0.6	-0.1	-0.8	0.5	0.6	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	-0.3	-0.6	0.4	0.4	0.7
Whole body water mass	0.2	0.9	1.8	-1.3	0.2	-1.0	-1.2	0.6
Financial situation satisfaction	0.2	0.2	1.0	0.1	1.0	-0.3	-0.3	-0.3
Medication: Paracetamol	0.2	0.4	1.5	-0.2	1.2	-0.4	-0.4	-0.2
Medication: Atorvastatin	0.2	0.3	0.6	-0.6	0.8	0.4	0.3	0.3
Arm fat-free mass (left)	0.2	1.0	1.8	-1.3	-0.0	-1.1	-1.3	0.6
Age started oral contraceptive pill	0.2	0.3	0.6	-0.4	0.2	0.7	0.8	0.4
Heart disease (siblings)	0.2	0.3	0.6	0.2	-0.2	0.6	0.7	-0.5
Schizophrenia (2018)	0.1	0.1	0.3	-0.5	0.2	-0.5	0.0	0.0
Lupus	0.1	0.1	0.3	-0.3	-0.1	-0.5	0.0	0.2
Blood Eosinophil Count	0.1	1.0	2.0	0.5	1.4	1.1	1.1	0.6
Blood Red Count	0.1	0.9	1.5	-1.2	0.6	-1.1	-1.1	-0.3
Smoking Status	0.1	0.2	0.9	-0.2	-1.0	-0.1	-0.1	-0.3
Chronotype (morning person)	0.1	0.2	0.8	-0.9	-0.0	-0.3	-0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.2	0.6	0.2	0.3	-0.4
Supplements: Zinc	0.1	0.1	0.5	-0.7	0.3	0.0	0.1	-0.2
Diabetes (father)	0.1	0.2	0.8	0.2	-0.9	0.0	0.1	-0.0
Taking other prescription medications	0.1	0.2	0.3	0.1	-0.3	-0.5	-0.6	0.3
Age when periods started (menarche)	0.1	0.4	1.2	1.1	0.4	0.1	0.1	-0.6
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.2	0.4
Nervous feelings	0.1	0.1	0.3	0.3	0.2	0.4	0.6	0.1
Mouth/teeth dental problems	0.1	0.2	0.3	0.3	0.6	-0.2	-0.3	0.6
Trunk fat-free mass	0.1	0.7	1.3	-1.1	0.1	-0.7	-0.8	1.0
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.6	0.0	0.1	0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.6	0.9	0.3	0.4	0.8
Pulse wave Arterial Stiffness index	0.1	0.2	0.6	-0.0	0.8	-0.3	-0.2	0.1
Trunk predicted mass	0.1	0.7	1.4	-1.2	0.0	-0.7	-0.9	1.0
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	-0.5	-0.1	0.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	0.0	0.3	-0.1	0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.5	0.3	0.1	0.1	0.7
Forced vital capacity (FVC), Best measure	0.1	0.5	1.2	-0.3	-1.1	-0.8	-0.7	-0.2
Number of full brothers	0.1	0.2	0.7	0.3	-0.8	0.0	0.1	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.4	-0.1	0.3	0.4	0.3
Pulse rate, automated reading	0.1	0.3	0.6	-0.8	-0.3	-0.5	-0.5	0.5
Alcohol intake frequency.	0.1	0.3	1.1	-0.6	1.1	-0.1	-0.1	-0.3
Number of full sisters	0.1	0.2	0.3	-0.2	-0.2	-0.5	-0.6	0.4
Chest pain or discomfort	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.1	-0.3
Age at last live birth	0.1	0.1	0.3	0.4	-0.4	-0.3	-0.2	0.5
Family relationship satisfaction	0.1	0.1	0.3	-0.6	-0.5	0.2	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.3	0.4	-0.7	-0.7	0.1
Leg fat-free mass (right)	0.1	0.7	1.3	-0.8	1.1	-0.8	-0.9	0.3
Mood swings	0.1	0.3	0.5	-0.6	0.1	-0.7	-0.6	-0.3
Back pain experienced in last month	0.1	0.1	0.4	-0.2	0.6	-0.1	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.6	0.3	-0.4	-0.3	-0.4
Leg predicted mass (right)	0.1	0.7	1.3	-0.8	1.1	-0.8	-0.9	0.3
Guilty feelings	0.1	0.2	0.5	0.0	0.7	0.4	0.5	-0.3
Wears glasses or contact lenses	0.1	0.1	0.1	0.2	-0.4	0.2	0.3	-0.3
Pain experienced in last month	0.1	0.2	0.6	-0.8	-0.5	-0.4	-0.3	-0.3
Supplements: Calcium	0.1	0.1	0.2	-0.2	-0.1	0.4	0.5	-0.2
Worry (Nagel 2018)	0.0	0.1	0.4	0.0	-0.3	-0.2	0.0	-0.6
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.1	0.1	-0.3	0.2	0.0	0.0
HDL Cholesterol	0.0	0.1	0.2	0.4	0.2	0.4	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.2	-0.4	0.0	0.2	0.0	0.0
Hypothyroidism (self reported)	0.0	0.0	0.1	0.1	0.1	-0.2	-0.3	-0.1
Hair Pigment	0.0	0.2	0.6	0.3	-0.2	0.4	0.4	-0.7
Sensitivity / hurt feelings	0.0	0.0	0.1	-0.1	0.2	-0.0	0.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.3	0.0	0.5	-0.1	-0.1	-0.0
Medication: Levothyroxine sodium	0.0	0.0	0.0	0.0	0.0	0.0	-0.0	-0.2
Neuroticism score	0.0	0.0	0.0	-0.2	0.0	-0.2	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.3	-0.2	-0.3	-0.3	0.4
Medication for pain relief, constipation, heartburn	0.0	0.1	0.3	0.2	-0.5	-0.0	-0.0	0.2
Ever depressed for a whole week	0.0	0.1	0.1	0.1	-0.1	0.2	0.2	0.4
Cholesterol lowering medication	0.0	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.2

Hub : Genes

AQP5

Models

Trait associations