Hub : Genes

PITPNM3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.165 0.0340 1.6e-10 0.059 0.115 0.131 0.126 0.130 9.1e-08 6.9e-14 1.2e-15 4.0e-15 1.4e-15
2 GTEx Brain Cerebellum 0.243 0.0930 7.9e-03 0.196 NA 0.098 NA 0.168 1.8e-06 NA 8.0e-04 NA 1.1e-05
3 GTEx Testis 0.414 0.0730 1.1e-07 0.310 NA 0.324 NA 0.344 2.7e-14 NA 5.4e-15 NA 5.2e-16
4 ROSMAP Brain Pre-frontal Cortex 0.104 0.0324 7.4e-04 0.010 0.042 0.024 0.047 0.016 1.7e-02 3.9e-06 4.3e-04 1.1e-06 3.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.0 1.6 2.1 1.4 -1.2 1.0 1.3
Bipolar Disorder or Schizophrenia 0.3 0.7 1.3 -0.1 0.3 1.2 1.1
Depressed Affect (Nagel 2018) 0.3 0.6 1.9 -0.4 -0.3 -0.4 1.4
Depression (Nagel 2018) 0.3 0.4 1.0 0.0 0.2 -1.0 0.8
Intelligence (Savage-Jansen 2018) 0.3 0.9 3.4 -0.3 -0.1 1.8 -0.4
Neuroticism (Nagel 2018) 0.1 0.3 0.6 -0.4 0.7 -0.8 0.2
Schizophrenia (2018) 0.4 0.9 1.9 -1.0 1.4 0.7 0.4
Schizophrenia vs Biploar Disorder 1.2 1.5 3.0 -1.7 1.6 -0.5 -0.5
Worry (Nagel 2018) 0.1 0.2 0.6 0.0 0.0 -0.1 -0.8
Alzheimer’s Disease (in mother) 2.1 2.5 6.5 2.5 -1.1 -1.4 0.5
Alzheimer’s Disease (in father) 1.4 1.5 4.7 0.3 -0.2 -1.1 2.2
Alzheimer’s Disease (including proxy) 1.3 1.9 3.3 1.8 -1.3 -0.8 1.5
Crohns Disease (2017) 0.1 0.3 1.0 -0.2 0.0 1.0 0.0
Irritable Bowel Disease (IBD) 0.9 2.1 6.9 0.4 -0.9 2.6 -0.6
Ulcerative Colitis (UC) 1.6 3.1 8.4 0.9 -1.6 2.9 -0.7
Major Depression (MDD) 1.4 1.7 2.9 0.5 -1.6 1.7 1.0
Reaction Time 2.3 4.5 7.1 2.5 -2.1 -2.7 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.3 0.7 -1.2 1.1 -0.5
Breast Cancer 0.5 1.2 2.4 -0.1 -0.5 1.5 -1.4
Ovarian Cancer 0.7 0.9 2.7 0.7 -1.6 0.4 0.4
Prostate Cancer 0.1 0.1 0.4 0.6 -0.2 0.1 -0.1
Age at First Birth 1.0 1.5 3.8 -0.8 0.8 2.0 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 2.4 1.0 -1.5 -0.6 -0.2
Coronary Artery Disease (CAD) 1.3 1.5 3.2 0.9 -1.3 -0.4 1.8
Crohns Disease (2012) 0.3 0.5 0.8 -0.5 0.9 0.4 0.9
Mean Putamen Volume 0.1 0.1 0.1 0.3 -0.4 0.4 0.0
Fasting Glucose 1.6 1.9 4.0 -0.6 -0.3 1.8 -2.0
HbA1C 0.2 0.2 0.7 0.8 -0.2 0.1 -0.2
HDL Cholesterol 0.7 1.2 2.9 -0.8 1.7 -0.8 -0.8
LDL Cholesterol 1.6 2.5 4.4 2.1 -2.0 -0.9 1.0
Lupus 0.5 0.7 2.3 0.2 0.1 -0.8 1.5
Neuroticism (2016) 0.2 0.4 0.7 0.1 0.8 -0.4 -0.8
Primary Biliary Cirrhosis 0.5 0.7 1.3 1.1 -1.1 -0.2 -0.3
Rheumatoid Arthritis 1.6 2.3 4.1 -1.1 -0.1 2.0 -2.0
Schizophrenia (2014) 0.1 0.3 0.6 -0.2 0.8 0.6 0.6
Triglycerides 0.5 0.8 1.8 1.3 -1.3 -0.2 0.0
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.6 0.7 -0.4 0.8 -0.3
Ulcerative Colitis 0.5 0.8 1.9 1.4 -1.0 0.3 0.3
Blood Eosinophil Count 0.5 3.5 8.2 2.0 -2.9 1.3 0.1
Blood Platelet Count 0.1 0.7 1.8 0.9 -1.3 0.2 -0.4
Blood Red Count 0.2 2.2 4.7 0.8 -2.2 1.5 1.1
Blood White Count 0.5 4.0 8.4 2.1 -2.9 1.6 0.6
Heel T-Score 0.2 1.5 4.0 -0.3 1.4 -2.0 -0.1
BMI 0.9 5.3 10.0 3.2 -2.4 -1.8 1.4
Height 0.7 12.6 38.2 -2.4 0.9 6.2 -2.4
Waist Hip Ratio (WHR) 1.0 4.4 13.2 1.0 -1.8 3.6 -0.3
Systolic Blood Pressure 2.1 10.6 37.0 0.2 -1.3 6.1 -1.9
Smoking Status 0.7 1.6 5.5 2.3 -0.6 -0.6 0.4
Allergy or Eczema 0.1 0.4 0.8 0.9 0.3 -0.3 0.7
Cardiovascular Disease 0.3 1.0 1.9 -0.4 -1.4 1.2 0.4
Hypothyroidism (self reported) 0.1 0.3 0.5 0.4 -0.7 -0.1 -0.7
Respiratory disease 0.1 0.3 0.5 0.2 -0.7 0.6 -0.2
Type 2 Diabetes (T2D) (2018) 0.9 1.8 3.7 1.9 -1.6 0.5 0.7
Lung FEV1/FVC ratio 2.2 10.9 26.1 3.1 -1.2 -5.1 2.6
Lung FVC 0.9 4.5 9.7 -0.2 1.9 -3.1 2.1
Neuroticism 0.3 0.8 1.7 -1.0 1.3 0.1 -0.7
Chronotype (morning person) 1.2 2.8 4.4 -2.1 1.6 1.3 -1.6
Hair Pigment 0.0 0.6 2.0 -0.3 -0.5 0.2 -1.4
Tanning 0.2 2.1 4.0 1.1 -1.7 2.0 0.4
Hand grip strength (left) 1.4 3.6 11.7 0.5 0.7 -3.4 1.4
Number of treatments/medications taken 0.2 0.3 0.6 0.0 -0.8 -0.5 -0.5
Average weekly spirits intake 0.4 0.5 1.3 -0.0 0.8 -1.2 0.2
Sensitivity / hurt feelings 0.2 0.3 0.8 -0.2 0.9 -0.7 -0.1
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 -0.4 1.1 -0.7 0.4
Hearing difficulty/problems: Yes 0.7 1.1 1.6 1.1 -0.9 0.7 -1.3
Relative age of first facial hair 0.3 0.7 1.6 0.2 -0.4 -1.0 -1.2
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.8 0.8 -0.5 0.2 -0.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 3.2 0.2 -0.1 0.5 -1.8
Ever had hysterectomy (womb removed) 1.0 1.1 2.2 0.4 1.4 -0.4 1.5
Systolic blood pressure, automated reading 1.1 3.3 7.5 1.1 -1.2 2.7 -1.7
Eye problems/disorders: Diabetes related eye disease 1.0 1.2 2.5 1.6 -0.7 -0.4 1.2
Angina 0.4 0.5 1.8 -0.5 0.1 1.3 0.0
Medication for hormone replacement therapy 0.3 0.3 0.6 0.8 0.0 -0.6 -0.6
Vitamin and mineral supplements 0.3 0.5 1.3 0.7 -0.1 1.1 -0.3
Supplements: Zinc 0.6 0.7 2.2 0.2 -0.6 0.0 1.5
Medication: Co-codamol 0.4 0.5 1.7 0.0 0.4 1.3 0.1
Medication: Metformin 0.1 0.2 0.3 0.6 0.3 -0.5 0.2
Diabetes (father) 0.5 0.6 1.8 0.2 0.1 -1.3 0.8
Diabetes (mother) 1.2 1.6 2.8 -0.4 -0.9 1.7 -1.6
Severe depression (siblings) 1.1 1.2 2.6 -1.1 1.6 0.5 -0.9
Pack years adult smoking proportion 0.6 0.9 1.8 -1.1 1.4 0.2 -0.6
Impedance of leg (right) 0.1 0.5 1.3 -0.1 -0.2 1.2 -0.7
Leg fat-free mass (left) 0.3 1.8 6.3 -0.6 -0.4 2.5 -0.5
Trunk fat percentage 0.8 3.3 6.7 0.9 -2.2 2.6 -0.8
Hand grip strength (right) 1.2 3.4 10.6 0.7 0.4 -3.3 1.5
Townsend deprivation index at recruitment 0.2 0.3 1.0 -0.3 0.4 -0.0 -1.0
Current tobacco smoking 1.0 1.6 4.2 2.1 -0.5 -0.6 1.2
Average weekly fortified wine intake 0.2 0.3 0.7 -0.4 0.4 -0.8 -0.1
Maternal smoking around birth 0.2 0.3 0.5 -0.7 -0.2 0.1 -0.7
Fed-up feelings 0.4 0.7 1.1 -0.5 0.6 -1.1 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 2.6 -1.4 1.6 -1.0 0.0
Relative age voice broke 0.7 1.1 1.7 -0.8 0.7 -1.3 -1.3
Taking other prescription medications 0.8 1.2 2.7 1.6 -1.4 -0.4 -0.4
Age when periods started (menarche) 2.1 5.1 8.4 -2.6 2.9 -0.0 -2.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.0 1.4 -0.7 -0.1 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.8 -0.5 0.9 -0.5 0.9
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 2.2 -1.2 0.1 -1.5 0.7
Qualifications: CSEs or equivalent 0.3 0.3 1.1 -0.2 0.4 -0.1 -1.1
Serious illness, injury or assault to yourself 0.8 1.0 2.7 0.8 -1.6 -0.7 -0.3
High blood pressure 0.4 1.2 3.0 0.3 -1.0 1.7 -0.7
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 1.0 -0.3 -0.2 0.7
Multivitamins +/- minerals 0.4 0.6 1.6 -0.1 -0.7 -1.2 0.5
Stomach or abdominal pain in last month 1.5 1.9 4.8 -0.9 0.3 1.3 -2.2
Supplements: Glucosamine 0.6 0.8 2.0 -0.6 0.7 0.6 -1.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.6 0.0 -1.3 0.5 0.1
Medication: Atenolol 0.4 0.6 1.1 -0.4 -0.9 1.1 0.3
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.0 -0.7 -0.6 -0.1
Sitting height 0.5 3.3 11.5 -1.1 -0.2 3.4 -0.5
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.2 0.2 -0.5 -0.3
High blood pressure (mother) 0.7 1.0 3.1 -0.9 0.3 1.8 -0.1
Body mass index (BMI) 0.5 2.0 5.0 1.6 -2.2 0.3 0.5
Impedance of leg (left) 0.1 0.5 1.4 0.0 -0.7 1.2 -0.2
Leg predicted mass (left) 0.3 1.7 6.2 -0.6 -0.4 2.5 -0.5
Trunk fat mass 0.8 3.2 7.6 0.8 -2.1 2.8 -0.7
Waist circumference 1.5 5.6 10.3 1.7 -3.0 3.2 -0.5
Number of incorrect matches in round 1.3 2.1 5.2 -2.3 0.2 0.9 -1.5
Past tobacco smoking 0.4 0.8 2.1 -1.4 0.6 0.5 -0.7
Alcohol usually taken with meals 0.4 0.7 2.6 0.1 -0.4 1.6 0.1
Nervous feelings 0.9 1.7 3.0 1.7 -1.5 -0.0 1.2
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 4.0 -1.4 1.1 0.4 -2.0
Hearing difficulty/problems with background noise 0.6 0.9 3.4 0.5 0.1 0.0 -1.8
Hair/balding pattern: Pattern 2 0.5 0.6 1.1 -1.0 1.1 -0.4 0.5
Had menopause 0.5 0.7 1.3 -0.4 0.6 -0.9 -1.1
Had other major operations 0.7 0.9 1.6 0.6 -1.2 -1.3 0.3
Forced vital capacity (FVC) 0.3 1.3 3.2 -0.3 1.8 -0.1 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.0 -0.6 1.7 -1.2 0.8
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.8 -1.2 1.3 0.4 -0.7
Qualifications: None of the above 0.2 0.5 1.6 0.1 -0.1 -1.3 0.6
Financial difficulties in last 2 years 2.1 2.8 9.8 -0.4 1.1 -0.1 -3.1
Mouth/teeth dental problems 0.6 0.9 2.2 -0.5 -0.9 1.5 0.6
Heart attack 0.7 0.9 3.1 -0.6 -0.5 0.2 -1.8
Allergy 1.0 2.2 3.6 -1.8 1.9 0.8 -1.1
Pain all over the body in last month 0.3 0.4 1.4 -0.2 -0.0 1.2 -0.0
Diabetes (self-reported) 0.7 1.0 2.1 1.1 -1.5 0.6 0.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 0.3 -0.5 0.3 -0.0
Medication: Ramipril 0.2 0.3 1.0 0.0 0.1 -1.0 0.3
Medication: Simvastatin 0.6 0.9 1.6 0.8 -1.3 0.4 1.1
Fluid intelligence score 0.7 1.5 3.7 0.4 -0.6 1.9 -1.2
Illnesses of siblings 0.4 0.6 1.7 0.3 -0.1 0.8 1.3
Neuroticism score 0.5 1.1 3.0 -1.1 1.7 -0.1 -0.4
Weight 0.5 2.7 6.5 0.7 -1.9 2.5 -0.4
Impedance of arm (right) 0.3 1.6 2.7 -0.9 0.9 1.6 -1.4
Arm fat percentage (right) 0.4 1.7 3.7 1.4 -1.9 1.0 -0.0
Trunk fat-free mass 0.1 0.8 3.1 -0.3 -0.3 1.8 -0.1
Hip circumference 0.5 2.0 3.5 0.9 -1.9 1.8 -0.6
Time employed in main current job 2.1 2.4 3.9 -1.7 2.0 0.9 -1.5
Alcohol intake versus 10 years previously 1.3 1.9 4.5 1.4 -2.1 0.0 1.2
Father’s age at death 1.9 2.6 5.5 -1.2 2.4 -0.8 -1.6
Worrier / anxious feelings 1.6 3.0 6.3 -1.7 1.6 -0.3 -2.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.9 0.3 0.1 -1.7 -0.3
Falls in the last year 0.3 0.4 0.8 -0.4 -0.3 0.9 -0.7
Hair/balding pattern: Pattern 3 0.4 0.6 1.3 -0.8 -0.6 0.3 -1.2
Number of live births 0.3 0.4 0.6 -0.8 0.7 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.4 0.2 1.6 -0.9 1.5
Pulse rate 1.0 1.7 3.6 1.9 -0.7 -1.3 0.9
Happiness 0.1 0.2 0.3 0.2 0.1 -0.5 0.6
Noisy workplace 0.4 0.5 1.5 -0.2 0.6 -1.2 -0.4
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.1 1.8 -1.2 1.3 0.2
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.5 5.3 -1.2 1.3 1.2 -2.3
Mouth/teeth dental problems: Dentures 0.3 0.6 2.0 0.3 -0.4 -0.1 -1.4
Asthma 0.3 0.5 1.4 0.0 -1.2 -0.3 0.7
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.9 -1.2 1.7 0.1 -0.9
Medication: Cholesterol lowering 0.3 0.4 0.9 0.4 -0.7 0.2 -1.0
Depression (self-reported) 0.6 0.7 1.4 0.7 -0.7 0.5 1.2
Medication: Lansoprazole 1.0 1.1 3.9 0.1 0.4 -2.0 0.6
Prospective memory result 0.5 0.6 1.3 0.4 -0.5 1.1 -0.9
Lung cancer (father) 0.8 1.0 3.0 0.8 0.3 -1.7 0.5
Illnesses of mother 1.4 1.7 5.1 0.5 -0.2 -2.3 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 4.5 1.2 0.9 -1.3 2.1
Pulse wave Arterial Stiffness index 0.8 1.0 2.7 0.2 -0.2 1.6 -1.1
Impedance of arm (left) 0.5 2.2 3.9 -0.8 0.9 1.8 -2.0
Arm fat mass (right) 0.4 1.6 3.2 1.0 -1.8 1.5 -0.1
Trunk predicted mass 0.1 0.8 3.1 -0.2 -0.4 1.8 -0.1
Standing height 0.9 8.7 26.7 -1.8 0.7 5.2 -2.1
Length of working week for main job 0.8 0.9 3.5 -0.1 0.3 -0.1 1.9
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.4 -0.1 0.1 -0.6
Breastfed as a baby 3.3 4.1 8.7 3.0 -1.7 -2.1 0.7
Tense / ‘highly strung’ 0.3 0.6 0.9 -0.9 0.6 -1.0 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 5.6 0.5 -0.7 2.4 0.2
Hair/balding pattern: Pattern 4 0.1 0.3 1.0 -0.2 -0.6 1.0 0.0
Birth weight of first child 0.1 0.1 0.3 -0.0 0.0 -0.5 0.5
Peak expiratory flow (PEF) 0.7 1.6 3.8 1.3 -0.2 -0.9 1.9
Pulse wave reflection index 1.3 1.6 2.5 -1.6 0.2 1.3 -1.4
Ever highly irritable/argumentative for 2 days 2.6 3.2 4.8 -2.1 1.8 -0.4 -2.2
Loud music exposure frequency 0.9 0.9 2.7 1.6 -0.5 -0.9 -0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 0.7 -0.1 0.5 -0.7
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 4.6 0.5 1.3 -2.1 0.7
Blood clot in the leg (DVT) 2.7 3.5 4.6 2.1 -1.9 -1.8 1.6
Medication: Paracetamol 0.3 0.6 1.7 -0.7 0.4 -0.2 -1.3
Headache pain in last month 0.4 0.8 1.3 -0.8 1.2 -0.0 -1.0
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.7 0.3 0.5 -0.8 0.2
Glaucoma (self-reported) 1.7 2.0 4.8 -0.6 1.0 -2.2 1.4
Gout (self-reported) 0.2 0.3 0.8 -0.9 0.6 0.2 -0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.1 1.0 -1.0 -0.2 -0.8
Medication: Amlodipine 1.3 1.8 3.7 1.2 -1.2 -0.9 1.9
Medication: Ventolin 100micrograms inhaler 1.0 1.3 2.1 -1.4 0.7 0.9 -1.3
Birth weight 0.4 0.9 2.3 -0.6 1.0 -1.5 -0.2
Chronic bronchitis/emphysema (mother) 1.0 1.2 3.6 -0.2 -0.6 1.9 -0.8
High blood pressure (siblings) 1.2 1.7 3.8 -1.1 0.4 -1.2 -1.9
Forced vital capacity (FVC), Best measure 0.3 1.1 3.2 0.7 0.8 -0.1 1.8
Body fat percentage 0.8 3.1 6.2 1.2 -2.5 2.1 -0.6
Leg fat percentage (right) 0.9 3.4 8.8 1.9 -3.0 1.0 -0.3
Arm fat-free mass (right) 0.2 1.1 3.4 0.0 -0.9 1.9 0.3
Exposure to tobacco smoke outside home 1.9 2.5 4.8 -2.2 1.7 -1.6 0.1
Comparative body size at age 10 0.3 0.7 2.0 0.4 0.8 -1.4 -0.1
Number of full brothers 2.1 2.6 4.5 2.1 -2.1 -1.1 0.6
Worry too long after embarrassment 1.7 2.8 5.9 -1.5 2.4 -1.6 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 9.2 -1.1 -0.3 3.0 -0.6
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 -0.2 -1.0 -0.1 -0.9
Number of children fathered 1.7 1.9 4.6 1.4 -2.1 0.4 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.8 -0.1 1.0 -0.7 1.3
Age at first live birth 0.9 1.6 4.1 -0.1 0.6 2.0 -1.4
Pulse wave peak to peak time 0.5 0.6 1.4 -0.4 0.5 -1.2 0.8
Health satisfaction 0.3 0.3 0.5 0.6 -0.6 -0.0 0.7
Shortness of breath walking on level ground 1.6 1.9 2.9 0.4 -1.7 1.4 -1.6
Qualifications: College or University degree 0.8 2.5 9.4 -0.9 -0.0 3.1 -0.1
Eye problems/disorders: None of the above 0.8 0.9 2.2 -1.5 1.0 0.1 -0.6
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.1 -1.1 0.4 0.3 -0.8
Emphysema/chronic bronchitis 0.3 0.4 0.6 0.5 -0.5 -0.7 0.8
Medication for pain relief, constipation, heartburn 0.4 0.6 1.6 0.7 -0.6 1.3 0.2
Neck or shoulder pain in last month 2.8 4.0 6.2 -2.2 2.5 0.4 -2.2
Medication: Blood pressure 0.5 0.9 2.9 0.1 -0.8 1.7 0.1
Angina (self-reported) 0.3 0.3 1.0 -0.3 -0.1 1.0 0.5
Migraine (self-reported) 1.1 1.3 2.9 -0.7 1.1 0.9 -1.7
Medication: Ibuprofen 0.3 0.3 0.4 -0.6 0.5 0.7 -0.4
Medication: Allopurinol 0.8 1.1 2.0 -1.4 0.8 0.8 -1.1
Medication: Omeprazole 0.6 0.7 1.6 -0.8 0.5 -0.6 -1.3
Medication: Seretide 50 evohaler 0.7 0.8 1.8 -0.3 0.6 1.0 -1.4
Mean time to correctly identify matches 2.7 5.2 13.5 2.0 -1.8 -3.7 0.1
Heart disease (mother) 1.3 1.6 4.9 -0.7 0.2 2.2 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.6 0.7 -0.8 0.5 -0.6
Whole body fat mass 0.7 3.0 5.9 1.0 -2.1 2.4 -0.7
Leg fat mass (right) 0.6 2.3 4.8 0.9 -2.2 1.8 -0.5
Arm predicted mass (right) 0.2 1.2 4.0 -0.2 -0.8 2.0 0.1
Pulse rate, automated reading 0.4 1.3 2.0 1.4 -1.1 -1.2 0.6
Alcohol intake frequency. 0.2 0.5 1.5 0.1 -0.4 -1.2 -0.5
Comparative height size at age 10 0.5 2.7 4.2 -2.1 1.4 1.7 -1.4
Number of full sisters 3.5 4.3 9.7 3.1 -0.8 -1.8 1.9
Suffer from ‘nerves’ 0.6 1.0 1.6 0.9 -1.3 1.1 -0.6
Overall health rating 0.1 0.3 0.4 -0.6 -0.6 -0.6 0.1
Chest pain or discomfort 0.3 0.4 0.7 0.5 -0.7 -0.8 -0.3
Had major operations 0.3 0.3 0.6 0.5 -0.5 -0.8 -0.2
Age at last live birth 0.9 1.4 3.6 -0.3 1.2 0.5 -1.9
Family relationship satisfaction 0.7 0.9 2.3 -0.0 1.5 -1.0 -0.5
Leg pain on walking 0.9 1.2 3.6 -0.9 0.3 0.4 -1.9
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.7 1.0 1.3 -0.6 -0.0
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.7 0.1 -0.9 0.1 -0.0
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.7 -1.0 0.7 1.3 1.6
Medication: Aspirin 0.5 0.6 1.5 -0.3 -0.7 -0.6 1.2
Supplements: Vitamin C 0.1 0.1 0.3 -0.1 0.2 -0.5 0.1
Knee pain experienced in last month 0.7 1.2 3.1 -0.2 1.7 -0.9 -0.9
Hypertension (Self-reported) 0.5 1.3 3.3 0.4 -1.2 1.8 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 6.4 -1.3 0.4 -2.5 -1.3
Illnesses of father: Heart disease 1.4 1.9 3.6 0.3 -1.8 1.9 0.9
Illnesses of siblings: Diabetes 0.5 0.6 2.1 0.2 -0.3 -0.3 -1.4
Smoking status: Previous 0.5 0.7 1.4 0.8 -0.3 -1.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 5.6 -1.3 -0.1 2.4 0.1
Whole body fat-free mass 0.2 1.3 5.0 -0.4 -0.4 2.2 -0.2
Leg fat-free mass (right) 0.3 1.7 6.2 -0.6 -0.4 2.5 -0.4
Arm fat percentage (left) 0.4 1.8 4.1 1.3 -2.0 1.1 -0.2
Average weekly red wine intake 0.1 0.1 0.2 0.3 0.2 0.4 0.2
Handedness (chirality/laterality): Left-handed 0.2 0.3 1.0 -0.1 0.1 0.1 1.0
Mood swings 0.3 0.5 1.1 -1.0 0.1 -0.8 0.3
Loneliness, isolation 1.4 1.9 4.8 -1.6 2.2 -0.0 -0.2
Long-standing illness, disability or infirmity 0.9 1.4 2.6 1.4 -1.6 1.1 0.3
Ever had bowel cancer screening 0.1 0.1 0.3 0.0 0.2 -0.6 0.0
Diabetes diagnosed by doctor 0.9 1.5 2.8 1.7 -1.7 0.7 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 0.6 0.6 -0.7 -0.3
Friendships satisfaction 1.2 1.4 3.7 -0.6 1.9 -0.9 -0.9
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.2 0.1 0.3 0.4
Commuting to job workplace: Walk 0.8 0.9 2.3 -0.9 -0.2 -0.5 -1.5
Eye problems/disorders: Cataract 0.8 0.9 2.3 -0.5 -0.2 1.0 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.2 -0.5 1.5 0.4 -0.6
Medication for cholesterol 0.2 0.3 0.6 0.8 0.0 -0.5 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.3 -0.9 1.2 0.0 -0.8
Back pain experienced in last month 3.5 5.0 8.0 -2.7 2.8 -0.7 -2.0
Mineral and other dietary supplements 0.4 0.5 1.2 0.9 -1.1 -0.2 0.3
Breast cancer (self-reported) 1.6 1.9 3.5 1.9 -1.4 -0.9 1.2
Asthma (self-reported) 0.4 0.8 1.9 0.3 -1.4 -0.7 0.9
Osteoporosis (self-reported) 0.3 0.3 0.7 0.4 0.4 -0.6 -0.8
Osteoarthritis (self-reported) 0.3 0.4 1.0 -0.3 1.0 0.2 -0.7
Medication: Aspirin 0.7 0.9 1.9 0.0 -1.2 0.1 1.4
Medication: Gliclazide 0.5 0.5 1.1 0.1 -0.3 1.0 -1.1
Illnesses of father: None of the above (group 1) 0.6 0.7 1.3 0.4 0.6 1.1 -1.0
Smoking status: Current 0.5 0.8 2.8 1.7 -0.3 0.2 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 2.8 -0.3 1.7 -1.7 1.1
Whole body water mass 0.2 1.2 4.4 -0.4 -0.5 2.1 -0.1
Leg predicted mass (right) 0.3 1.8 6.6 -0.6 -0.4 2.6 -0.4
Arm fat mass (left) 0.4 1.8 3.6 1.0 -1.9 1.6 -0.0
Number of self-reported non-cancer illnesses 1.2 2.0 4.0 0.7 -2.0 0.7 -1.7
Average weekly champagne plus white wine intake 0.6 0.8 2.0 -0.3 1.4 -0.9 -0.5
Miserableness 0.5 0.8 2.0 -1.0 1.4 -0.6 -0.2
Guilty feelings 3.3 4.9 9.7 -3.0 3.1 -0.6 -0.6
Wears glasses or contact lenses 1.7 2.0 4.1 -1.1 0.4 1.6 -2.0
Ever taken oral contraceptive pill 0.5 0.5 1.0 -0.6 -0.1 -0.8 -1.0
Hearing aid user 0.2 0.2 0.5 -0.1 0.7 -0.1 -0.5
Mother’s age at death 0.7 0.9 1.5 -0.6 1.2 -0.6 1.1
Financial situation satisfaction 0.8 1.0 1.5 1.2 -1.1 0.3 1.2
Tinnitus: Yes, now most or all of the time 1.1 1.3 3.6 -0.4 1.0 -0.7 -1.9
Commuting to job workplace: Public transport 0.5 0.6 1.2 -1.1 0.9 0.5 0.4
Eye problems/disorders: Glaucoma 2.8 3.4 11.0 -0.1 0.4 -3.3 1.5
Medication: Blood pressure 0.3 0.6 1.5 0.3 -1.2 0.9 -0.3
Pain type(s) experienced in last month: Hip pain 1.4 1.7 2.6 -1.3 1.4 -0.8 -1.6
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.0 -0.3 1.0 -0.5 0.9
High cholesterol (Self-reported) 0.5 0.9 2.0 -0.8 -0.9 1.4 -0.4
Medication: Bendroflumethiazide 1.0 1.6 2.8 1.0 -1.7 1.5 -0.6
Medication: Paracetamol 0.2 0.4 0.7 -0.6 0.5 -0.3 -0.9
Medication: Lisinopril 0.3 0.4 1.0 0.5 -0.1 1.0 -0.6
Medication: Atorvastatin 0.7 0.9 1.5 0.8 -1.2 0.8 -0.9
Illnesses of father: High blood pressure 0.3 0.4 1.0 0.3 -0.5 -1.0 -0.5
Alcohol drinker status: Never 0.3 0.4 0.7 0.6 -0.1 -0.8 -0.6
Ever smoked 0.9 1.6 4.0 2.0 -1.0 -0.8 1.0
Basal metabolic rate 0.3 1.8 6.4 -0.3 -0.8 2.5 -0.2
Leg fat percentage (left) 1.0 3.6 9.4 2.0 -3.1 1.0 -0.1
Arm fat-free mass (left) 0.2 1.2 3.3 0.2 -1.0 1.8 0.6
Number of operations (self-reported) 3.0 4.5 7.3 2.6 -2.7 -1.1 1.7
Average weekly beer plus cider intake 1.1 1.7 2.5 1.2 -1.6 -0.5 1.5
Irritability 1.8 3.0 7.4 -1.6 1.1 0.7 -2.7
Risk taking 0.8 1.2 1.8 -1.2 1.2 0.2 -1.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.8 -1.3 1.0 0.4 -0.2
Fractured/broken bones in last 5 years 0.3 0.4 0.6 0.8 -0.7 -0.5 0.4
Age started oral contraceptive pill 0.5 0.7 2.1 -0.0 0.6 -1.4 -0.5
Diastolic blood pressure, automated reading 0.8 2.6 5.1 1.9 -1.2 -2.3 -0.5
Ever depressed for a whole week 0.6 0.8 1.4 -0.7 0.3 1.2 -1.1
Unable to work because of sickness or disability 1.4 1.8 3.8 1.4 -1.2 -0.4 1.9
Commuting to job workplace: Cycle 1.8 2.2 3.0 1.6 -1.7 1.0 1.4
Myopia 0.2 0.3 0.6 -0.3 -0.7 0.6 0.5
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.5 0.1 1.2 -1.6 1.1
Cholesterol lowering medication 0.4 0.6 1.7 -0.7 -0.6 1.3 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.1 -0.3 -0.2 -1.1 0.2
Pain experienced in last month 0.5 0.8 2.2 0.0 -1.0 -0.3 1.5
Supplements: Calcium 0.1 0.1 0.3 -0.1 0.6 -0.1 -0.5
Basal cell carcinoma (self-reported) 0.4 0.4 1.2 -0.4 1.1 0.3 0.6
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.2 -0.5 -0.5 0.1 -1.8
Deep venous thrombosis (DVT) (self-reported) 3.0 3.8 4.5 2.1 -2.1 -1.9 1.8
Heart disease (siblings) 2.1 2.6 6.2 0.8 1.0 -2.5 1.6
Alcohol drinker status: Previous 0.5 0.6 0.9 -1.0 0.5 0.8 -0.8
Pack years of smoking 0.8 1.2 2.2 -1.0 1.5 0.2 -1.2
Impedance of whole body 0.3 1.5 4.1 -0.6 0.2 2.0 -1.3
Leg fat mass (left) 0.6 2.3 4.8 0.9 -2.2 1.8 -0.5
Arm predicted mass (left) 0.2 1.2 3.6 0.3 -0.9 1.9 0.5