Hub : Genes

PITPNM3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.165	0.0340	1.6e-10	0.059	0.115	0.131	0.126	0.130	9.1e-08	6.9e-14	1.2e-15	4.0e-15	1.4e-15
2	GTEx	Brain Cerebellum	0.243	0.0930	7.9e-03	0.196	NA	0.098	NA	0.168	1.8e-06	NA	8.0e-04	NA	1.1e-05
3	GTEx	Testis	0.414	0.0730	1.1e-07	0.310	NA	0.324	NA	0.344	2.7e-14	NA	5.4e-15	NA	5.2e-16
4	ROSMAP	Brain Pre-frontal Cortex	0.104	0.0324	7.4e-04	0.010	0.042	0.024	0.047	0.016	1.7e-02	3.9e-06	4.3e-04	1.1e-06	3.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.0	1.6	2.1	1.4	-1.2	1.0	1.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.3	-0.1	0.3	1.2	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	1.9	-0.4	-0.3	-0.4	1.4
Depression (Nagel 2018)	0.3	0.4	1.0	0.0	0.2	-1.0	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.4	-0.3	-0.1	1.8	-0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.4	0.7	-0.8	0.2
Schizophrenia (2018)	0.4	0.9	1.9	-1.0	1.4	0.7	0.4
Schizophrenia vs Biploar Disorder	1.2	1.5	3.0	-1.7	1.6	-0.5	-0.5
Worry (Nagel 2018)	0.1	0.2	0.6	0.0	0.0	-0.1	-0.8
Alzheimer’s Disease (in mother)	2.1	2.5	6.5	2.5	-1.1	-1.4	0.5
Alzheimer’s Disease (in father)	1.4	1.5	4.7	0.3	-0.2	-1.1	2.2
Alzheimer’s Disease (including proxy)	1.3	1.9	3.3	1.8	-1.3	-0.8	1.5
Crohns Disease (2017)	0.1	0.3	1.0	-0.2	0.0	1.0	0.0
Irritable Bowel Disease (IBD)	0.9	2.1	6.9	0.4	-0.9	2.6	-0.6
Ulcerative Colitis (UC)	1.6	3.1	8.4	0.9	-1.6	2.9	-0.7
Major Depression (MDD)	1.4	1.7	2.9	0.5	-1.6	1.7	1.0
Reaction Time	2.3	4.5	7.1	2.5	-2.1	-2.7	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.3	0.7	-1.2	1.1	-0.5
Breast Cancer	0.5	1.2	2.4	-0.1	-0.5	1.5	-1.4
Ovarian Cancer	0.7	0.9	2.7	0.7	-1.6	0.4	0.4
Prostate Cancer	0.1	0.1	0.4	0.6	-0.2	0.1	-0.1
Age at First Birth	1.0	1.5	3.8	-0.8	0.8	2.0	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.4	1.0	-1.5	-0.6	-0.2
Coronary Artery Disease (CAD)	1.3	1.5	3.2	0.9	-1.3	-0.4	1.8
Crohns Disease (2012)	0.3	0.5	0.8	-0.5	0.9	0.4	0.9
Mean Putamen Volume	0.1	0.1	0.1	0.3	-0.4	0.4	0.0
Fasting Glucose	1.6	1.9	4.0	-0.6	-0.3	1.8	-2.0
HbA1C	0.2	0.2	0.7	0.8	-0.2	0.1	-0.2
HDL Cholesterol	0.7	1.2	2.9	-0.8	1.7	-0.8	-0.8
LDL Cholesterol	1.6	2.5	4.4	2.1	-2.0	-0.9	1.0
Lupus	0.5	0.7	2.3	0.2	0.1	-0.8	1.5
Neuroticism (2016)	0.2	0.4	0.7	0.1	0.8	-0.4	-0.8
Primary Biliary Cirrhosis	0.5	0.7	1.3	1.1	-1.1	-0.2	-0.3
Rheumatoid Arthritis	1.6	2.3	4.1	-1.1	-0.1	2.0	-2.0
Schizophrenia (2014)	0.1	0.3	0.6	-0.2	0.8	0.6	0.6
Triglycerides	0.5	0.8	1.8	1.3	-1.3	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	0.7	-0.4	0.8	-0.3
Ulcerative Colitis	0.5	0.8	1.9	1.4	-1.0	0.3	0.3
Blood Eosinophil Count	0.5	3.5	8.2	2.0	-2.9	1.3	0.1
Blood Platelet Count	0.1	0.7	1.8	0.9	-1.3	0.2	-0.4
Blood Red Count	0.2	2.2	4.7	0.8	-2.2	1.5	1.1
Blood White Count	0.5	4.0	8.4	2.1	-2.9	1.6	0.6
Heel T-Score	0.2	1.5	4.0	-0.3	1.4	-2.0	-0.1
BMI	0.9	5.3	10.0	3.2	-2.4	-1.8	1.4
Height	0.7	12.6	38.2	-2.4	0.9	6.2	-2.4
Waist Hip Ratio (WHR)	1.0	4.4	13.2	1.0	-1.8	3.6	-0.3
Systolic Blood Pressure	2.1	10.6	37.0	0.2	-1.3	6.1	-1.9
Smoking Status	0.7	1.6	5.5	2.3	-0.6	-0.6	0.4
Allergy or Eczema	0.1	0.4	0.8	0.9	0.3	-0.3	0.7
Cardiovascular Disease	0.3	1.0	1.9	-0.4	-1.4	1.2	0.4
Hypothyroidism (self reported)	0.1	0.3	0.5	0.4	-0.7	-0.1	-0.7
Respiratory disease	0.1	0.3	0.5	0.2	-0.7	0.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.9	1.8	3.7	1.9	-1.6	0.5	0.7
Lung FEV1/FVC ratio	2.2	10.9	26.1	3.1	-1.2	-5.1	2.6
Lung FVC	0.9	4.5	9.7	-0.2	1.9	-3.1	2.1
Neuroticism	0.3	0.8	1.7	-1.0	1.3	0.1	-0.7
Chronotype (morning person)	1.2	2.8	4.4	-2.1	1.6	1.3	-1.6
Hair Pigment	0.0	0.6	2.0	-0.3	-0.5	0.2	-1.4
Tanning	0.2	2.1	4.0	1.1	-1.7	2.0	0.4
Hand grip strength (left)	1.4	3.6	11.7	0.5	0.7	-3.4	1.4
Number of treatments/medications taken	0.2	0.3	0.6	0.0	-0.8	-0.5	-0.5
Average weekly spirits intake	0.4	0.5	1.3	-0.0	0.8	-1.2	0.2
Sensitivity / hurt feelings	0.2	0.3	0.8	-0.2	0.9	-0.7	-0.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.4	1.1	-0.7	0.4
Hearing difficulty/problems: Yes	0.7	1.1	1.6	1.1	-0.9	0.7	-1.3
Relative age of first facial hair	0.3	0.7	1.6	0.2	-0.4	-1.0	-1.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.8	-0.5	0.2	-0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.2	0.2	-0.1	0.5	-1.8
Ever had hysterectomy (womb removed)	1.0	1.1	2.2	0.4	1.4	-0.4	1.5
Systolic blood pressure, automated reading	1.1	3.3	7.5	1.1	-1.2	2.7	-1.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.2	2.5	1.6	-0.7	-0.4	1.2
Angina	0.4	0.5	1.8	-0.5	0.1	1.3	0.0
Medication for hormone replacement therapy	0.3	0.3	0.6	0.8	0.0	-0.6	-0.6
Vitamin and mineral supplements	0.3	0.5	1.3	0.7	-0.1	1.1	-0.3
Supplements: Zinc	0.6	0.7	2.2	0.2	-0.6	0.0	1.5
Medication: Co-codamol	0.4	0.5	1.7	0.0	0.4	1.3	0.1
Medication: Metformin	0.1	0.2	0.3	0.6	0.3	-0.5	0.2
Diabetes (father)	0.5	0.6	1.8	0.2	0.1	-1.3	0.8
Diabetes (mother)	1.2	1.6	2.8	-0.4	-0.9	1.7	-1.6
Severe depression (siblings)	1.1	1.2	2.6	-1.1	1.6	0.5	-0.9
Pack years adult smoking proportion	0.6	0.9	1.8	-1.1	1.4	0.2	-0.6
Impedance of leg (right)	0.1	0.5	1.3	-0.1	-0.2	1.2	-0.7
Leg fat-free mass (left)	0.3	1.8	6.3	-0.6	-0.4	2.5	-0.5
Trunk fat percentage	0.8	3.3	6.7	0.9	-2.2	2.6	-0.8
Hand grip strength (right)	1.2	3.4	10.6	0.7	0.4	-3.3	1.5
Townsend deprivation index at recruitment	0.2	0.3	1.0	-0.3	0.4	-0.0	-1.0
Current tobacco smoking	1.0	1.6	4.2	2.1	-0.5	-0.6	1.2
Average weekly fortified wine intake	0.2	0.3	0.7	-0.4	0.4	-0.8	-0.1
Maternal smoking around birth	0.2	0.3	0.5	-0.7	-0.2	0.1	-0.7
Fed-up feelings	0.4	0.7	1.1	-0.5	0.6	-1.1	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.6	-1.4	1.6	-1.0	0.0
Relative age voice broke	0.7	1.1	1.7	-0.8	0.7	-1.3	-1.3
Taking other prescription medications	0.8	1.2	2.7	1.6	-1.4	-0.4	-0.4
Age when periods started (menarche)	2.1	5.1	8.4	-2.6	2.9	-0.0	-2.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.0	1.4	-0.7	-0.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	-0.5	0.9	-0.5	0.9
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.2	-1.2	0.1	-1.5	0.7
Qualifications: CSEs or equivalent	0.3	0.3	1.1	-0.2	0.4	-0.1	-1.1
Serious illness, injury or assault to yourself	0.8	1.0	2.7	0.8	-1.6	-0.7	-0.3
High blood pressure	0.4	1.2	3.0	0.3	-1.0	1.7	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	1.0	-0.3	-0.2	0.7
Multivitamins +/- minerals	0.4	0.6	1.6	-0.1	-0.7	-1.2	0.5
Stomach or abdominal pain in last month	1.5	1.9	4.8	-0.9	0.3	1.3	-2.2
Supplements: Glucosamine	0.6	0.8	2.0	-0.6	0.7	0.6	-1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	0.0	-1.3	0.5	0.1
Medication: Atenolol	0.4	0.6	1.1	-0.4	-0.9	1.1	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.0	-0.7	-0.6	-0.1
Sitting height	0.5	3.3	11.5	-1.1	-0.2	3.4	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.2	-0.5	-0.3
High blood pressure (mother)	0.7	1.0	3.1	-0.9	0.3	1.8	-0.1
Body mass index (BMI)	0.5	2.0	5.0	1.6	-2.2	0.3	0.5
Impedance of leg (left)	0.1	0.5	1.4	0.0	-0.7	1.2	-0.2
Leg predicted mass (left)	0.3	1.7	6.2	-0.6	-0.4	2.5	-0.5
Trunk fat mass	0.8	3.2	7.6	0.8	-2.1	2.8	-0.7
Waist circumference	1.5	5.6	10.3	1.7	-3.0	3.2	-0.5
Number of incorrect matches in round	1.3	2.1	5.2	-2.3	0.2	0.9	-1.5
Past tobacco smoking	0.4	0.8	2.1	-1.4	0.6	0.5	-0.7
Alcohol usually taken with meals	0.4	0.7	2.6	0.1	-0.4	1.6	0.1
Nervous feelings	0.9	1.7	3.0	1.7	-1.5	-0.0	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	4.0	-1.4	1.1	0.4	-2.0
Hearing difficulty/problems with background noise	0.6	0.9	3.4	0.5	0.1	0.0	-1.8
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	-1.0	1.1	-0.4	0.5
Had menopause	0.5	0.7	1.3	-0.4	0.6	-0.9	-1.1
Had other major operations	0.7	0.9	1.6	0.6	-1.2	-1.3	0.3
Forced vital capacity (FVC)	0.3	1.3	3.2	-0.3	1.8	-0.1	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	-0.6	1.7	-1.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.8	-1.2	1.3	0.4	-0.7
Qualifications: None of the above	0.2	0.5	1.6	0.1	-0.1	-1.3	0.6
Financial difficulties in last 2 years	2.1	2.8	9.8	-0.4	1.1	-0.1	-3.1
Mouth/teeth dental problems	0.6	0.9	2.2	-0.5	-0.9	1.5	0.6
Heart attack	0.7	0.9	3.1	-0.6	-0.5	0.2	-1.8
Allergy	1.0	2.2	3.6	-1.8	1.9	0.8	-1.1
Pain all over the body in last month	0.3	0.4	1.4	-0.2	-0.0	1.2	-0.0
Diabetes (self-reported)	0.7	1.0	2.1	1.1	-1.5	0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.3	-0.5	0.3	-0.0
Medication: Ramipril	0.2	0.3	1.0	0.0	0.1	-1.0	0.3
Medication: Simvastatin	0.6	0.9	1.6	0.8	-1.3	0.4	1.1
Fluid intelligence score	0.7	1.5	3.7	0.4	-0.6	1.9	-1.2
Illnesses of siblings	0.4	0.6	1.7	0.3	-0.1	0.8	1.3
Neuroticism score	0.5	1.1	3.0	-1.1	1.7	-0.1	-0.4
Weight	0.5	2.7	6.5	0.7	-1.9	2.5	-0.4
Impedance of arm (right)	0.3	1.6	2.7	-0.9	0.9	1.6	-1.4
Arm fat percentage (right)	0.4	1.7	3.7	1.4	-1.9	1.0	-0.0
Trunk fat-free mass	0.1	0.8	3.1	-0.3	-0.3	1.8	-0.1
Hip circumference	0.5	2.0	3.5	0.9	-1.9	1.8	-0.6
Time employed in main current job	2.1	2.4	3.9	-1.7	2.0	0.9	-1.5
Alcohol intake versus 10 years previously	1.3	1.9	4.5	1.4	-2.1	0.0	1.2
Father’s age at death	1.9	2.6	5.5	-1.2	2.4	-0.8	-1.6
Worrier / anxious feelings	1.6	3.0	6.3	-1.7	1.6	-0.3	-2.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.9	0.3	0.1	-1.7	-0.3
Falls in the last year	0.3	0.4	0.8	-0.4	-0.3	0.9	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	-0.8	-0.6	0.3	-1.2
Number of live births	0.3	0.4	0.6	-0.8	0.7	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	0.2	1.6	-0.9	1.5
Pulse rate	1.0	1.7	3.6	1.9	-0.7	-1.3	0.9
Happiness	0.1	0.2	0.3	0.2	0.1	-0.5	0.6
Noisy workplace	0.4	0.5	1.5	-0.2	0.6	-1.2	-0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.1	1.8	-1.2	1.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	5.3	-1.2	1.3	1.2	-2.3
Mouth/teeth dental problems: Dentures	0.3	0.6	2.0	0.3	-0.4	-0.1	-1.4
Asthma	0.3	0.5	1.4	0.0	-1.2	-0.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.9	-1.2	1.7	0.1	-0.9
Medication: Cholesterol lowering	0.3	0.4	0.9	0.4	-0.7	0.2	-1.0
Depression (self-reported)	0.6	0.7	1.4	0.7	-0.7	0.5	1.2
Medication: Lansoprazole	1.0	1.1	3.9	0.1	0.4	-2.0	0.6
Prospective memory result	0.5	0.6	1.3	0.4	-0.5	1.1	-0.9
Lung cancer (father)	0.8	1.0	3.0	0.8	0.3	-1.7	0.5
Illnesses of mother	1.4	1.7	5.1	0.5	-0.2	-2.3	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.5	1.2	0.9	-1.3	2.1
Pulse wave Arterial Stiffness index	0.8	1.0	2.7	0.2	-0.2	1.6	-1.1
Impedance of arm (left)	0.5	2.2	3.9	-0.8	0.9	1.8	-2.0
Arm fat mass (right)	0.4	1.6	3.2	1.0	-1.8	1.5	-0.1
Trunk predicted mass	0.1	0.8	3.1	-0.2	-0.4	1.8	-0.1
Standing height	0.9	8.7	26.7	-1.8	0.7	5.2	-2.1
Length of working week for main job	0.8	0.9	3.5	-0.1	0.3	-0.1	1.9
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.4	-0.1	0.1	-0.6
Breastfed as a baby	3.3	4.1	8.7	3.0	-1.7	-2.1	0.7
Tense / ‘highly strung’	0.3	0.6	0.9	-0.9	0.6	-1.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	5.6	0.5	-0.7	2.4	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.2	-0.6	1.0	0.0
Birth weight of first child	0.1	0.1	0.3	-0.0	0.0	-0.5	0.5
Peak expiratory flow (PEF)	0.7	1.6	3.8	1.3	-0.2	-0.9	1.9
Pulse wave reflection index	1.3	1.6	2.5	-1.6	0.2	1.3	-1.4
Ever highly irritable/argumentative for 2 days	2.6	3.2	4.8	-2.1	1.8	-0.4	-2.2
Loud music exposure frequency	0.9	0.9	2.7	1.6	-0.5	-0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.7	-0.1	0.5	-0.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.6	0.5	1.3	-2.1	0.7
Blood clot in the leg (DVT)	2.7	3.5	4.6	2.1	-1.9	-1.8	1.6
Medication: Paracetamol	0.3	0.6	1.7	-0.7	0.4	-0.2	-1.3
Headache pain in last month	0.4	0.8	1.3	-0.8	1.2	-0.0	-1.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.3	0.5	-0.8	0.2
Glaucoma (self-reported)	1.7	2.0	4.8	-0.6	1.0	-2.2	1.4
Gout (self-reported)	0.2	0.3	0.8	-0.9	0.6	0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.1	1.0	-1.0	-0.2	-0.8
Medication: Amlodipine	1.3	1.8	3.7	1.2	-1.2	-0.9	1.9
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.1	-1.4	0.7	0.9	-1.3
Birth weight	0.4	0.9	2.3	-0.6	1.0	-1.5	-0.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	3.6	-0.2	-0.6	1.9	-0.8
High blood pressure (siblings)	1.2	1.7	3.8	-1.1	0.4	-1.2	-1.9
Forced vital capacity (FVC), Best measure	0.3	1.1	3.2	0.7	0.8	-0.1	1.8
Body fat percentage	0.8	3.1	6.2	1.2	-2.5	2.1	-0.6
Leg fat percentage (right)	0.9	3.4	8.8	1.9	-3.0	1.0	-0.3
Arm fat-free mass (right)	0.2	1.1	3.4	0.0	-0.9	1.9	0.3
Exposure to tobacco smoke outside home	1.9	2.5	4.8	-2.2	1.7	-1.6	0.1
Comparative body size at age 10	0.3	0.7	2.0	0.4	0.8	-1.4	-0.1
Number of full brothers	2.1	2.6	4.5	2.1	-2.1	-1.1	0.6
Worry too long after embarrassment	1.7	2.8	5.9	-1.5	2.4	-1.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	9.2	-1.1	-0.3	3.0	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-0.2	-1.0	-0.1	-0.9
Number of children fathered	1.7	1.9	4.6	1.4	-2.1	0.4	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	-0.1	1.0	-0.7	1.3
Age at first live birth	0.9	1.6	4.1	-0.1	0.6	2.0	-1.4
Pulse wave peak to peak time	0.5	0.6	1.4	-0.4	0.5	-1.2	0.8
Health satisfaction	0.3	0.3	0.5	0.6	-0.6	-0.0	0.7
Shortness of breath walking on level ground	1.6	1.9	2.9	0.4	-1.7	1.4	-1.6
Qualifications: College or University degree	0.8	2.5	9.4	-0.9	-0.0	3.1	-0.1
Eye problems/disorders: None of the above	0.8	0.9	2.2	-1.5	1.0	0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.1	-1.1	0.4	0.3	-0.8
Emphysema/chronic bronchitis	0.3	0.4	0.6	0.5	-0.5	-0.7	0.8
Medication for pain relief, constipation, heartburn	0.4	0.6	1.6	0.7	-0.6	1.3	0.2
Neck or shoulder pain in last month	2.8	4.0	6.2	-2.2	2.5	0.4	-2.2
Medication: Blood pressure	0.5	0.9	2.9	0.1	-0.8	1.7	0.1
Angina (self-reported)	0.3	0.3	1.0	-0.3	-0.1	1.0	0.5
Migraine (self-reported)	1.1	1.3	2.9	-0.7	1.1	0.9	-1.7
Medication: Ibuprofen	0.3	0.3	0.4	-0.6	0.5	0.7	-0.4
Medication: Allopurinol	0.8	1.1	2.0	-1.4	0.8	0.8	-1.1
Medication: Omeprazole	0.6	0.7	1.6	-0.8	0.5	-0.6	-1.3
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.3	0.6	1.0	-1.4
Mean time to correctly identify matches	2.7	5.2	13.5	2.0	-1.8	-3.7	0.1
Heart disease (mother)	1.3	1.6	4.9	-0.7	0.2	2.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.7	-0.8	0.5	-0.6
Whole body fat mass	0.7	3.0	5.9	1.0	-2.1	2.4	-0.7
Leg fat mass (right)	0.6	2.3	4.8	0.9	-2.2	1.8	-0.5
Arm predicted mass (right)	0.2	1.2	4.0	-0.2	-0.8	2.0	0.1
Pulse rate, automated reading	0.4	1.3	2.0	1.4	-1.1	-1.2	0.6
Alcohol intake frequency.	0.2	0.5	1.5	0.1	-0.4	-1.2	-0.5
Comparative height size at age 10	0.5	2.7	4.2	-2.1	1.4	1.7	-1.4
Number of full sisters	3.5	4.3	9.7	3.1	-0.8	-1.8	1.9
Suffer from ‘nerves’	0.6	1.0	1.6	0.9	-1.3	1.1	-0.6
Overall health rating	0.1	0.3	0.4	-0.6	-0.6	-0.6	0.1
Chest pain or discomfort	0.3	0.4	0.7	0.5	-0.7	-0.8	-0.3
Had major operations	0.3	0.3	0.6	0.5	-0.5	-0.8	-0.2
Age at last live birth	0.9	1.4	3.6	-0.3	1.2	0.5	-1.9
Family relationship satisfaction	0.7	0.9	2.3	-0.0	1.5	-1.0	-0.5
Leg pain on walking	0.9	1.2	3.6	-0.9	0.3	0.4	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.7	1.0	1.3	-0.6	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.1	-0.9	0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	-1.0	0.7	1.3	1.6
Medication: Aspirin	0.5	0.6	1.5	-0.3	-0.7	-0.6	1.2
Supplements: Vitamin C	0.1	0.1	0.3	-0.1	0.2	-0.5	0.1
Knee pain experienced in last month	0.7	1.2	3.1	-0.2	1.7	-0.9	-0.9
Hypertension (Self-reported)	0.5	1.3	3.3	0.4	-1.2	1.8	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	6.4	-1.3	0.4	-2.5	-1.3
Illnesses of father: Heart disease	1.4	1.9	3.6	0.3	-1.8	1.9	0.9
Illnesses of siblings: Diabetes	0.5	0.6	2.1	0.2	-0.3	-0.3	-1.4
Smoking status: Previous	0.5	0.7	1.4	0.8	-0.3	-1.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.6	-1.3	-0.1	2.4	0.1
Whole body fat-free mass	0.2	1.3	5.0	-0.4	-0.4	2.2	-0.2
Leg fat-free mass (right)	0.3	1.7	6.2	-0.6	-0.4	2.5	-0.4
Arm fat percentage (left)	0.4	1.8	4.1	1.3	-2.0	1.1	-0.2
Average weekly red wine intake	0.1	0.1	0.2	0.3	0.2	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.0	-0.1	0.1	0.1	1.0
Mood swings	0.3	0.5	1.1	-1.0	0.1	-0.8	0.3
Loneliness, isolation	1.4	1.9	4.8	-1.6	2.2	-0.0	-0.2
Long-standing illness, disability or infirmity	0.9	1.4	2.6	1.4	-1.6	1.1	0.3
Ever had bowel cancer screening	0.1	0.1	0.3	0.0	0.2	-0.6	0.0
Diabetes diagnosed by doctor	0.9	1.5	2.8	1.7	-1.7	0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.6	0.6	-0.7	-0.3
Friendships satisfaction	1.2	1.4	3.7	-0.6	1.9	-0.9	-0.9
Qualifications: nursing, teaching	0.0	0.1	0.1	-0.2	0.1	0.3	0.4
Commuting to job workplace: Walk	0.8	0.9	2.3	-0.9	-0.2	-0.5	-1.5
Eye problems/disorders: Cataract	0.8	0.9	2.3	-0.5	-0.2	1.0	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.2	-0.5	1.5	0.4	-0.6
Medication for cholesterol	0.2	0.3	0.6	0.8	0.0	-0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-0.9	1.2	0.0	-0.8
Back pain experienced in last month	3.5	5.0	8.0	-2.7	2.8	-0.7	-2.0
Mineral and other dietary supplements	0.4	0.5	1.2	0.9	-1.1	-0.2	0.3
Breast cancer (self-reported)	1.6	1.9	3.5	1.9	-1.4	-0.9	1.2
Asthma (self-reported)	0.4	0.8	1.9	0.3	-1.4	-0.7	0.9
Osteoporosis (self-reported)	0.3	0.3	0.7	0.4	0.4	-0.6	-0.8
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.3	1.0	0.2	-0.7
Medication: Aspirin	0.7	0.9	1.9	0.0	-1.2	0.1	1.4
Medication: Gliclazide	0.5	0.5	1.1	0.1	-0.3	1.0	-1.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.3	0.4	0.6	1.1	-1.0
Smoking status: Current	0.5	0.8	2.8	1.7	-0.3	0.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.8	-0.3	1.7	-1.7	1.1
Whole body water mass	0.2	1.2	4.4	-0.4	-0.5	2.1	-0.1
Leg predicted mass (right)	0.3	1.8	6.6	-0.6	-0.4	2.6	-0.4
Arm fat mass (left)	0.4	1.8	3.6	1.0	-1.9	1.6	-0.0
Number of self-reported non-cancer illnesses	1.2	2.0	4.0	0.7	-2.0	0.7	-1.7
Average weekly champagne plus white wine intake	0.6	0.8	2.0	-0.3	1.4	-0.9	-0.5
Miserableness	0.5	0.8	2.0	-1.0	1.4	-0.6	-0.2
Guilty feelings	3.3	4.9	9.7	-3.0	3.1	-0.6	-0.6
Wears glasses or contact lenses	1.7	2.0	4.1	-1.1	0.4	1.6	-2.0
Ever taken oral contraceptive pill	0.5	0.5	1.0	-0.6	-0.1	-0.8	-1.0
Hearing aid user	0.2	0.2	0.5	-0.1	0.7	-0.1	-0.5
Mother’s age at death	0.7	0.9	1.5	-0.6	1.2	-0.6	1.1
Financial situation satisfaction	0.8	1.0	1.5	1.2	-1.1	0.3	1.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.6	-0.4	1.0	-0.7	-1.9
Commuting to job workplace: Public transport	0.5	0.6	1.2	-1.1	0.9	0.5	0.4
Eye problems/disorders: Glaucoma	2.8	3.4	11.0	-0.1	0.4	-3.3	1.5
Medication: Blood pressure	0.3	0.6	1.5	0.3	-1.2	0.9	-0.3
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.6	-1.3	1.4	-0.8	-1.6
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.0	-0.3	1.0	-0.5	0.9
High cholesterol (Self-reported)	0.5	0.9	2.0	-0.8	-0.9	1.4	-0.4
Medication: Bendroflumethiazide	1.0	1.6	2.8	1.0	-1.7	1.5	-0.6
Medication: Paracetamol	0.2	0.4	0.7	-0.6	0.5	-0.3	-0.9
Medication: Lisinopril	0.3	0.4	1.0	0.5	-0.1	1.0	-0.6
Medication: Atorvastatin	0.7	0.9	1.5	0.8	-1.2	0.8	-0.9
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.3	-0.5	-1.0	-0.5
Alcohol drinker status: Never	0.3	0.4	0.7	0.6	-0.1	-0.8	-0.6
Ever smoked	0.9	1.6	4.0	2.0	-1.0	-0.8	1.0
Basal metabolic rate	0.3	1.8	6.4	-0.3	-0.8	2.5	-0.2
Leg fat percentage (left)	1.0	3.6	9.4	2.0	-3.1	1.0	-0.1
Arm fat-free mass (left)	0.2	1.2	3.3	0.2	-1.0	1.8	0.6
Number of operations (self-reported)	3.0	4.5	7.3	2.6	-2.7	-1.1	1.7
Average weekly beer plus cider intake	1.1	1.7	2.5	1.2	-1.6	-0.5	1.5
Irritability	1.8	3.0	7.4	-1.6	1.1	0.7	-2.7
Risk taking	0.8	1.2	1.8	-1.2	1.2	0.2	-1.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	-1.3	1.0	0.4	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.8	-0.7	-0.5	0.4
Age started oral contraceptive pill	0.5	0.7	2.1	-0.0	0.6	-1.4	-0.5
Diastolic blood pressure, automated reading	0.8	2.6	5.1	1.9	-1.2	-2.3	-0.5
Ever depressed for a whole week	0.6	0.8	1.4	-0.7	0.3	1.2	-1.1
Unable to work because of sickness or disability	1.4	1.8	3.8	1.4	-1.2	-0.4	1.9
Commuting to job workplace: Cycle	1.8	2.2	3.0	1.6	-1.7	1.0	1.4
Myopia	0.2	0.3	0.6	-0.3	-0.7	0.6	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.5	0.1	1.2	-1.6	1.1
Cholesterol lowering medication	0.4	0.6	1.7	-0.7	-0.6	1.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.1	-0.3	-0.2	-1.1	0.2
Pain experienced in last month	0.5	0.8	2.2	0.0	-1.0	-0.3	1.5
Supplements: Calcium	0.1	0.1	0.3	-0.1	0.6	-0.1	-0.5
Basal cell carcinoma (self-reported)	0.4	0.4	1.2	-0.4	1.1	0.3	0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.2	-0.5	-0.5	0.1	-1.8
Deep venous thrombosis (DVT) (self-reported)	3.0	3.8	4.5	2.1	-2.1	-1.9	1.8
Heart disease (siblings)	2.1	2.6	6.2	0.8	1.0	-2.5	1.6
Alcohol drinker status: Previous	0.5	0.6	0.9	-1.0	0.5	0.8	-0.8
Pack years of smoking	0.8	1.2	2.2	-1.0	1.5	0.2	-1.2
Impedance of whole body	0.3	1.5	4.1	-0.6	0.2	2.0	-1.3
Leg fat mass (left)	0.6	2.3	4.8	0.9	-2.2	1.8	-0.5
Arm predicted mass (left)	0.2	1.2	3.6	0.3	-0.9	1.9	0.5