TWAS hub - GIMAP7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.0740	0.0330	3.8e-03	0.013	NA	0.016	NA	0.009	3.0e-02	NA	2.0e-02	NA	6.4e-02
2	YFS	Blood	0.0677	0.0191	3.2e-12	0.043	0.05	0.057	0.055	0.050	6.1e-14	4.5e-16	6.7e-18	1.5e-17	5.6e-16
3	TCGA	Prostate Adenocarcinoma	0.0670	0.0452	4.0e-03	0.014	0.02	0.010	NA	0.012	1.2e-02	2.8e-03	2.8e-02	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Diastolic blood pressure, automated reading	7.8	24.3	41.2	4.1	6.4	3.8
Mouth/teeth dental problems: Mouth ulcers	7.0	11.2	12.2	3.1	3.4	3.5
Systolic Blood Pressure	5.9	29.3	54.3	4.6	7.4	3.6
Systolic blood pressure, automated reading	5.8	16.9	23.9	4.5	4.9	2.6
Tinnitus: Yes, but not now, but have in the past	5.6	6.0	9.2	2.6	3.0	1.5
Impedance of leg (left)	4.9	23.7	34.6	-5.2	-5.9	-3.1
Impedance of leg (right)	4.6	22.3	33.4	-4.6	-5.8	-3.5
Ovarian Cancer	4.5	5.9	9.9	3.1	2.4	1.5
Allergy or Eczema	4.0	10.5	12.6	-2.6	-3.5	-3.6
Blood Eosinophil Count	3.3	25.8	43.3	-6.6	-5.0	-3.1
Waist Hip Ratio (WHR)	3.1	13.8	15.4	-3.4	-3.8	-3.9
Tinnitus: Yes, now most or all of the time	3.1	3.6	5.1	-1.4	-2.2	-1.9
Number of incorrect matches in round	3.0	5.0	6.6	-2.6	-2.6	-1.3
High blood pressure	2.8	7.9	17.6	1.4	4.2	2.0
High blood pressure (mother)	2.8	3.9	8.7	1.0	3.0	1.5
Age started oral contraceptive pill	2.8	3.6	6.1	-0.5	-2.5	-2.1
Impedance of whole body	2.8	14.2	18.6	-4.3	-4.2	-2.6
Bipolar Disorder (2011)	2.7	2.6	3.3	1.8	1.3	-1.7
Vascular/heart problems diagnosed by doctor	2.7	7.4	16.7	-1.3	-4.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	7.2	-2.0	-2.7	-0.9
Pain all over the body in last month	2.6	2.7	5.4	1.6	2.3	0.7
Ever had prostate specific antigen (PSA) test	2.6	3.0	3.8	1.6	1.6	1.9
Cardiovascular Disease	2.5	8.2	20.7	0.7	4.5	1.9
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	5.8	0.5	1.4	2.4
Qualifications: CSEs or equivalent	2.4	3.1	6.4	0.3	2.5	1.7
Hayfever, allergic rhinitis or eczema	2.4	5.1	6.6	-2.2	-2.0	-2.6
Hypertension (Self-reported)	2.4	6.7	14.6	1.2	3.8	2.0
Alcohol drinker status: Never	2.3	2.8	7.3	2.7	0.7	0.7
Qualifications: O levels/GCSEs or equivalent	2.2	3.4	6.0	-0.4	-2.0	-2.5
Medication: Amlodipine	2.2	3.1	7.3	1.2	2.7	0.8
Commuting to job workplace: Car/motor vehicle	2.2	2.6	3.5	1.6	1.2	1.9
Reaction Time	2.1	4.1	6.5	-2.5	-1.3	-2.0
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	3.0	-1.6	-1.7	-1.6
Pulse wave reflection index	2.0	2.4	5.0	2.2	1.1	1.0
Loud music exposure frequency	2.0	2.1	3.4	-1.6	-0.7	-1.8
Headache pain in last month	2.0	3.4	6.6	0.3	1.8	2.6
Eye problems/disorders: Cataract	2.0	2.3	3.1	-1.4	-1.8	-1.4
Bipolar Disorder (2018)	1.9	3.0	8.9	0.1	0.3	-3.0
Illnesses of mother	1.9	2.3	4.1	0.4	-1.7	-2.0
High blood pressure (siblings)	1.9	2.7	5.9	0.7	2.4	1.3
Illnesses of father: High blood pressure	1.9	2.4	4.7	0.9	2.2	1.3
Cholesterol lowering medication	1.9	2.8	7.7	-2.8	0.0	-0.8
HDL Cholesterol	1.8	3.1	3.6	1.9	1.9	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.8	0.4	0.4	2.6
Alcohol usually taken with meals	1.8	2.9	6.6	-1.4	-2.6	-0.4
Age at first live birth	1.8	3.2	7.5	-2.7	-1.4	0.6
Financial situation satisfaction	1.8	2.2	2.5	-1.6	-1.4	-1.5
Medication: Blood pressure	1.8	3.3	9.2	0.1	3.0	0.9
Schizophrenia vs Biploar Disorder	1.7	2.2	5.6	0.8	0.7	2.4
Medication: Atenolol	1.7	2.1	5.3	-0.3	1.0	2.3
Hair/balding pattern: Pattern 2	1.7	2.2	3.5	0.8	1.6	1.9
Pain type(s) experienced in last month: Hip pain	1.7	2.2	2.9	1.6	1.7	1.0
Pain experienced in last month	1.7	2.9	5.4	-1.0	-1.5	-2.3
Lupus	1.6	2.4	3.6	-0.3	-1.8	-1.9
Birth weight	1.6	3.4	6.1	-0.2	-2.5	-2.0
Pulse wave peak to peak time	1.6	1.8	3.2	-1.8	-0.4	-1.5
Health satisfaction	1.6	2.1	3.8	-2.0	-1.2	-1.0
Medication for cholesterol	1.6	2.4	3.7	0.7	-1.9	-1.8
Medication: Gliclazide	1.6	1.8	3.1	-1.8	-0.5	-1.4
HbA1C	1.5	1.6	3.6	0.8	1.9	0.8
Diabetes (mother)	1.5	1.9	3.5	-1.9	-1.2	-0.8
Hand grip strength (right)	1.5	4.2	7.3	-0.5	-2.2	-2.7
Hearing difficulty/problems with background noise	1.5	2.4	5.6	0.5	2.4	1.2
Noisy workplace	1.5	1.9	2.2	-1.1	-1.5	-1.5
Medication: Allopurinol	1.5	2.0	4.6	-2.2	-1.0	-0.5
Had major operations	1.5	1.8	4.9	-0.6	-2.2	-0.1
Miserableness	1.5	2.6	5.1	-2.3	-1.5	-0.6
Guilty feelings	1.5	2.3	3.4	-1.4	-1.8	-1.2
Hand grip strength (left)	1.4	3.7	6.2	-0.4	-2.2	-2.5
Ever had hysterectomy (womb removed)	1.4	1.6	3.1	-1.8	-1.2	-0.3
Supplements: Glucosamine	1.4	1.8	4.9	-0.1	-0.8	2.2
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	1.7	1.2	1.3	1.3
Lung FEV1/FVC ratio	1.3	6.6	7.6	-2.5	-2.8	-2.4
Diabetes (self-reported)	1.3	1.9	3.0	-1.1	-1.3	-1.7
Pulse wave Arterial Stiffness index	1.3	1.5	3.2	1.8	0.2	1.1
Birth weight of first child	1.3	2.4	4.4	-0.8	-1.5	-2.1
Shortness of breath walking on level ground	1.3	1.6	2.7	-1.6	-1.4	0.0
Heart disease (mother)	1.3	1.6	2.9	0.9	1.0	1.7
Age at last live birth	1.3	1.9	2.9	-0.4	1.7	1.7
Diabetes diagnosed by doctor	1.3	2.1	3.3	-1.5	-0.7	-1.8
Friendships satisfaction	1.3	1.6	3.8	-1.9	-0.3	-1.0
Alcohol drinker status: Previous	1.3	1.4	3.5	-1.9	-0.9	0.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.7	-0.7	-0.0	-1.9
Mouth/teeth dental problems	1.2	1.9	3.3	-1.1	-1.8	-1.1
Depression (self-reported)	1.2	1.4	2.6	-1.6	-1.2	-0.6
Leg fat-free mass (right)	1.2	6.4	10.2	3.2	2.8	0.9
Mother’s age at death	1.2	1.5	3.2	-0.8	-1.8	-0.9
Risk taking	1.2	1.8	2.9	-1.6	-1.7	-0.1
Supplements: Calcium	1.2	1.3	3.6	1.9	-0.6	-0.2
Alzheimer’s Disease (in father)	1.1	1.2	3.3	-0.4	-1.8	0.3
BMI	1.1	6.3	10.8	2.2	3.3	1.8
Height	1.1	22.0	42.8	1.2	-6.5	-4.7
Number of treatments/medications taken	1.1	2.0	3.9	0.8	1.2	2.0
Leg fat-free mass (left)	1.1	5.7	9.7	3.1	2.6	0.6
Body mass index (BMI)	1.1	4.7	7.7	1.8	2.8	1.8
Leg predicted mass (left)	1.1	5.9	10.4	3.2	2.7	0.6
Heart attack	1.1	1.4	1.9	1.3	1.4	0.8
Impedance of arm (right)	1.1	5.0	8.8	-3.0	-2.1	-1.3
Alcohol intake versus 10 years previously	1.1	1.7	3.7	-1.1	-0.4	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	4.3	0.6	-2.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.4	-1.0	-1.6	-0.8
Leg predicted mass (right)	1.1	6.0	9.6	3.1	2.8	0.8
Commuting to job workplace: Public transport	1.1	1.3	2.1	-1.2	-0.5	-1.4
Irritability	1.1	1.8	4.0	-2.0	-0.8	-0.8
Verbal and Numeric Reasoning (VNR)	1.0	2.3	6.5	0.3	-0.6	-2.5
Coronary Artery Disease (CAD)	1.0	1.1	1.7	0.5	1.2	1.3
LDL Cholesterol	1.0	1.6	4.1	-0.9	0.3	2.0
Neuroticism (2016)	1.0	1.5	2.6	-1.3	-1.6	0.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.6	-1.6	-0.6	0.6
Hip circumference	1.0	4.3	5.8	2.4	2.4	1.2
Impedance of arm (left)	1.0	4.7	9.8	-3.1	-1.6	-1.4
Neck or shoulder pain in last month	1.0	1.4	3.3	0.4	0.9	1.8
Ever had bowel cancer screening	1.0	1.2	3.3	1.8	0.5	0.1
Commuting to job workplace: Walk	1.0	1.1	2.2	-0.9	1.5	0.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.1	-1.8	-0.6	-0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.2	1.9	1.1	1.4	0.7
Ulcerative Colitis	0.9	1.3	2.5	1.2	-0.1	1.6
Average weekly spirits intake	0.9	1.1	2.0	1.1	-0.2	-1.4
Medication for hormone replacement therapy	0.9	1.0	2.6	-0.2	0.6	1.6
Medication: Ramipril	0.9	1.2	1.8	-1.4	-0.6	-1.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.1	2.5	0.0	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	-1.6	-0.8	-0.0
Medication: Paracetamol	0.9	1.4	1.9	0.7	1.4	1.4
Gout (self-reported)	0.9	1.2	2.5	-1.6	-0.8	0.6
Number of children fathered	0.9	1.1	1.4	-1.0	-0.9	-1.2
Eye problems/disorders: None of the above	0.9	1.1	1.6	0.8	1.3	0.9
Knee pain experienced in last month	0.9	1.5	2.0	-1.4	-1.3	-0.8
Long-standing illness, disability or infirmity	0.9	1.4	3.8	-0.6	0.4	1.9
Osteoporosis (self-reported)	0.9	1.1	2.2	1.5	0.1	1.0
Eye problems/disorders: Glaucoma	0.9	1.1	1.4	1.1	0.9	1.2
Medication: Bendroflumethiazide	0.9	1.3	3.9	0.0	2.0	0.1
Commuting to job workplace: Cycle	0.9	1.1	2.0	-1.1	-0.4	-1.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	-0.3	-0.3	-1.6
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.8	-1.7	-0.8	0.4
Diabetes (father)	0.8	1.0	1.3	0.8	-1.1	-1.0
Financial difficulties in last 2 years	0.8	1.1	2.3	0.1	1.0	-1.5
Mouth/teeth dental problems: Dentures	0.8	1.3	2.8	0.5	1.0	-1.7
Prospective memory result	0.8	0.9	1.5	-1.2	-0.7	-0.9
Trunk predicted mass	0.8	4.5	12.0	3.5	1.1	-0.3
Hair/balding pattern: Pattern 4	0.8	1.9	2.1	-1.4	-1.3	-1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	-0.0	-1.6	-1.1
Whole body fat-free mass	0.8	4.8	11.2	3.3	1.8	0.1
Whole body water mass	0.8	4.5	10.8	3.3	1.6	-0.0
Heart disease (siblings)	0.8	1.0	2.1	1.4	0.9	-0.0
Major Depression (MDD)	0.7	0.9	1.4	-0.3	-1.2	-1.1
Hearing difficulty/problems: Yes	0.7	1.1	1.7	0.3	1.3	1.2
Vitamin and mineral supplements	0.7	1.0	2.0	0.5	1.4	-0.8
Townsend deprivation index at recruitment	0.7	1.0	1.6	0.8	1.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	2.4	-0.6	-1.6	-1.5
Nervous feelings	0.7	1.2	1.7	-1.3	-0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.5	-0.3	-1.6	-1.5
Trunk fat-free mass	0.7	4.3	11.6	3.4	1.1	-0.4
Pulse rate	0.7	1.1	2.9	0.3	1.7	0.6
Asthma	0.7	1.4	2.8	-0.8	-1.7	-0.9
Exposure to tobacco smoke at home	0.7	0.7	1.9	-0.1	1.4	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	-1.4	-0.6	-0.1
Family relationship satisfaction	0.7	0.8	1.6	-1.3	0.1	-0.9
Supplements: Vitamin C	0.7	0.9	2.0	1.4	-0.6	-0.5
Arm fat percentage (left)	0.7	2.6	5.7	0.6	2.4	1.4
High cholesterol (Self-reported)	0.7	1.3	2.3	-1.5	0.4	-1.1
Basal metabolic rate	0.7	3.6	8.3	2.9	1.6	0.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.9	-0.3	1.2
Body Mass Index (BMI) (2010)	0.6	0.9	1.2	0.7	1.1	0.9
Crohns Disease (2012)	0.6	1.0	3.1	0.0	1.8	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.0	-0.9	-0.8	-1.4
Chronotype (morning person)	0.6	1.4	1.8	1.1	-1.1	-1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.9	-0.9	-0.5	-1.0
Supplements: Zinc	0.6	0.7	1.0	0.8	-1.0	-0.7
Medication: Simvastatin	0.6	0.9	1.7	-1.3	-0.9	-0.2
Arm fat percentage (right)	0.6	2.5	4.5	0.8	2.1	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.9	1.4	0.5	0.3
Lung cancer (father)	0.6	0.7	1.8	-0.3	-0.1	1.4
Standing height	0.6	6.2	9.3	1.7	-2.5	-3.0
Length of working week for main job	0.6	0.6	1.0	0.8	-1.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.7	-1.3	0.4	0.5
Emphysema/chronic bronchitis	0.6	0.7	1.4	1.2	0.7	0.3
Medication: Ibuprofen	0.6	0.7	2.0	1.4	0.0	0.2
Comparative height size at age 10	0.6	3.4	6.2	2.5	-0.9	-1.7
Number of full sisters	0.6	0.7	1.4	0.1	1.2	0.9
Illnesses of father: Heart disease	0.6	0.8	2.3	-1.5	0.1	-0.4
Mineral and other dietary supplements	0.6	0.8	1.7	0.4	1.3	-0.6
Ever taken oral contraceptive pill	0.6	0.6	1.5	0.3	-1.2	0.6
Medication: Lisinopril	0.6	0.7	1.2	1.0	0.2	1.1
Medication: Atorvastatin	0.6	0.8	1.5	-0.5	1.2	-0.7
Fractured/broken bones in last 5 years	0.6	0.8	2.5	-1.6	0.2	-0.2
Unable to work because of sickness or disability	0.6	0.8	1.2	-1.1	0.2	-1.0
Myopia	0.6	0.9	2.1	-0.7	-1.4	-0.3
Bipolar Disorder or Schizophrenia	0.5	1.2	2.8	0.3	0.8	-1.7
Depression (Nagel 2018)	0.5	0.7	1.1	0.1	-1.0	1.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.2	0.3	-0.1	-2.0
Age at First Birth	0.5	0.7	1.8	-0.1	0.5	1.3
Respiratory disease	0.5	1.1	2.9	-0.5	-1.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	-0.5	-1.3	-0.4
Relative age voice broke	0.5	0.8	1.3	-1.1	-0.5	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.5	1.1	1.0	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	-1.1	0.7	0.2
Qualifications: None of the above	0.5	1.0	1.7	0.1	1.1	1.3
Allergy	0.5	1.2	2.1	0.7	1.0	1.5
Weight	0.5	2.4	5.1	2.3	1.4	0.2
Number of live births	0.5	0.7	1.5	1.2	0.6	0.5
Arm fat mass (right)	0.5	2.1	3.5	1.4	1.9	1.0
Breastfed as a baby	0.5	0.6	1.2	1.1	0.5	0.6
Blood clot in the leg (DVT)	0.5	0.6	0.8	0.6	0.9	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	-0.1	0.0	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.8	-0.0	-1.3	0.3
Medication: Blood pressure	0.5	0.9	1.6	-1.2	0.3	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.2	-1.2	0.6
Loneliness, isolation	0.5	0.7	1.3	0.5	1.1	0.7
Breast cancer (self-reported)	0.5	0.5	0.7	0.8	0.6	0.8
Asthma (self-reported)	0.5	0.9	1.9	-0.8	-1.4	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	-0.8	-0.8	-0.7
Arm fat mass (left)	0.5	2.2	3.9	1.4	2.0	0.9
Arm fat-free mass (left)	0.5	2.5	7.2	2.7	0.5	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	0.9	0.6	-1.0	0.7
Arm predicted mass (left)	0.5	2.5	7.0	2.6	0.4	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	0.6	-0.6	1.1
Crohns Disease (2017)	0.4	0.9	2.0	-0.4	1.4	-0.7
Primary Biliary Cirrhosis	0.4	0.5	1.2	0.6	1.1	0.1
Rheumatoid Arthritis	0.4	0.5	0.7	0.6	0.9	0.7
Blood Red Count	0.4	4.3	7.0	0.7	-2.3	-2.6
Medication: Metformin	0.4	0.6	1.0	-0.9	-0.2	-1.0
Past tobacco smoking	0.4	0.7	1.0	-1.0	-1.0	0.0
Had menopause	0.4	0.5	0.8	0.9	-0.4	-0.8
Forced vital capacity (FVC)	0.4	1.6	4.1	2.0	-0.3	-0.8
Illnesses of siblings	0.4	0.5	0.8	-0.9	-0.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	0.6	-0.4	-1.2
Happiness	0.4	0.5	0.8	-0.8	0.9	-0.3
Medication: Lansoprazole	0.4	0.5	0.9	0.4	-1.0	-0.5
Forced vital capacity (FVC), Best measure	0.4	1.4	3.2	1.8	-0.4	-1.0
Arm fat-free mass (right)	0.4	2.0	5.5	2.4	0.6	-0.5
Worry too long after embarrassment	0.4	0.7	1.1	-0.9	-1.0	-0.3
Arm predicted mass (right)	0.4	2.1	5.8	2.4	0.5	-0.6
Alcohol intake frequency.	0.4	0.8	2.4	0.2	1.6	-0.2
Chest pain or discomfort	0.4	0.6	1.0	0.5	1.0	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	-1.1	-0.4	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.2	-1.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	0.5	0.8	0.7
Breast Cancer	0.3	0.8	1.4	0.2	1.0	-1.2
Mean Putamen Volume	0.3	0.4	0.7	0.8	0.4	0.4
Blood Platelet Count	0.3	3.3	5.4	2.3	0.3	-2.1
Heel T-Score	0.3	2.2	5.5	-0.3	-2.3	-1.0
Lung FVC	0.3	1.3	1.9	1.4	1.0	1.0
Medication: Co-codamol	0.3	0.3	0.9	-0.4	-0.1	0.9
Severe depression (siblings)	0.3	0.4	1.1	-0.1	-0.2	1.0
Fed-up feelings	0.3	0.6	1.3	-1.1	-0.2	-0.7
Multivitamins +/- minerals	0.3	0.4	0.7	-0.6	-0.3	0.8
Sitting height	0.3	1.8	2.4	1.0	-1.6	-1.4
Fluid intelligence score	0.3	0.6	0.7	0.7	0.7	-0.8
Time employed in main current job	0.3	0.3	0.4	0.7	0.5	0.6
Worrier / anxious feelings	0.3	0.5	0.8	-0.7	-0.9	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	1.0	0.3	-0.0
Tense / ‘highly strung’	0.3	0.5	0.7	0.0	0.9	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.6	0.4	0.8
Number of full brothers	0.3	0.4	1.0	0.0	0.3	-1.0
Mean time to correctly identify matches	0.3	0.6	1.1	-0.7	-0.5	-1.0
Pulse rate, automated reading	0.3	1.1	2.2	-0.9	1.5	0.6
Suffer from ‘nerves’	0.3	0.5	1.4	-1.2	0.3	0.3
Overall health rating	0.3	0.6	1.4	-0.4	0.5	1.2
Leg pain on walking	0.3	0.4	1.2	-1.1	0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	-0.7	-0.1	-0.8
Average weekly red wine intake	0.3	0.5	1.2	-0.4	-0.4	1.1
Mood swings	0.3	0.6	1.0	-0.8	-0.4	1.0
Qualifications: nursing, teaching	0.3	0.4	1.2	1.1	0.2	0.1
Osteoarthritis (self-reported)	0.3	0.4	0.5	-0.7	-0.4	0.6
Hearing aid user	0.3	0.4	1.1	0.2	1.0	0.1
Ever smoked	0.3	0.5	0.8	0.9	0.6	-0.6
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.0	0.8	-0.8
Fasting Glucose	0.2	0.2	0.3	-0.5	-0.5	0.2
Triglycerides	0.2	0.3	0.5	0.7	0.6	0.1
Smoking Status	0.2	0.5	1.0	-0.1	1.0	-0.6
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.8	-0.1	0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.3	-0.8	0.3
Average weekly fortified wine intake	0.2	0.2	0.3	0.6	-0.5	-0.0
Age when periods started (menarche)	0.2	0.6	1.5	0.5	0.1	1.2
Stomach or abdominal pain in last month	0.2	0.3	0.4	0.6	0.6	-0.0
Medication: Levothyroxine sodium	0.2	0.3	0.8	0.0	0.9	0.0
Waist circumference	0.2	0.8	1.3	1.1	1.0	-0.3
Had other major operations	0.2	0.2	0.4	-0.4	-0.6	0.4
Neuroticism score	0.2	0.5	1.3	-1.1	-0.5	-0.1
Falls in the last year	0.2	0.3	0.4	-0.6	0.7	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.2	0.6	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.5	0.4	-0.7	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.8	-0.3	-0.3
Glaucoma (self-reported)	0.2	0.2	0.3	0.6	0.4	0.5
Exposure to tobacco smoke outside home	0.2	0.3	0.8	0.0	0.9	0.0
Comparative body size at age 10	0.2	0.7	2.0	-1.4	-0.2	0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.5	0.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.7	-0.1	0.4
Qualifications: College or University degree	0.2	0.8	1.1	0.3	-1.1	-1.0
Angina (self-reported)	0.2	0.2	0.5	-0.7	-0.2	-0.4
Medication: Omeprazole	0.2	0.2	0.6	-0.8	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.4	-0.7	0.4
Medication: Aspirin	0.2	0.3	0.6	-0.8	0.0	0.6
Smoking status: Previous	0.2	0.4	0.7	0.8	0.5	-0.4
Medication: Aspirin	0.2	0.2	0.4	-0.7	-0.4	-0.2
Smoking status: Current	0.2	0.3	0.4	-0.6	0.4	-0.5
Wears glasses or contact lenses	0.2	0.3	0.4	0.6	-0.6	-0.4
Medication: Paracetamol	0.2	0.3	0.5	0.1	0.7	0.5
Ever depressed for a whole week	0.2	0.3	0.8	-0.0	-0.1	-0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.1	-0.1	0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.7	-0.5	0.4
Schizophrenia (2018)	0.1	0.3	0.7	0.2	0.8	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	-0.5	0.7	-0.1
Ulcerative Colitis (UC)	0.1	0.1	0.1	-0.4	-0.3	0.3
Prostate Cancer	0.1	0.2	0.2	-0.5	-0.3	0.5
Neuroticism	0.1	0.1	0.2	-0.5	-0.2	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.5	-0.1	0.6
Relative age of first facial hair	0.1	0.1	0.2	-0.5	-0.3	-0.3
Angina	0.1	0.2	0.4	-0.7	0.1	-0.2
Current tobacco smoking	0.1	0.2	0.4	-0.3	0.4	-0.6
Maternal smoking around birth	0.1	0.2	0.3	0.2	-0.5	-0.4
Taking other prescription medications	0.1	0.2	0.4	0.4	-0.2	0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.0	-0.1	-0.5
Trunk fat mass	0.1	0.3	0.5	0.7	0.7	0.2
Father’s age at death	0.1	0.1	0.2	0.4	0.0	0.4
Medication: Cholesterol lowering	0.1	0.2	0.4	0.3	0.6	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.1	-0.5	-0.6
Migraine (self-reported)	0.1	0.1	0.1	0.2	-0.4	0.2
Whole body fat mass	0.1	0.5	0.7	0.8	0.8	0.4
Leg fat mass (right)	0.1	0.5	0.9	0.9	0.8	0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.5	-0.2	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	-0.0	0.1	0.6
Back pain experienced in last month	0.1	0.2	0.5	-0.1	-0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.4	-0.6	-0.3
Number of self-reported non-cancer illnesses	0.1	0.3	0.4	-0.2	0.6	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.0	0.4	0.2
Number of operations (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.2
Leg fat mass (left)	0.1	0.5	0.8	0.9	0.8	0.5
Worry (Nagel 2018)	0.0	0.1	0.3	0.1	0.1	0.5
Schizophrenia (2014)	0.0	0.0	0.1	0.0	0.3	-0.1
Blood White Count	0.0	0.3	0.9	0.2	-0.2	-0.9
Hair Pigment	0.0	0.1	0.3	0.3	0.6	-0.0
Tanning	0.0	0.6	1.6	0.2	-1.3	0.4
Pack years adult smoking proportion	0.0	0.1	0.1	-0.4	0.2	-0.1
Trunk fat percentage	0.0	0.2	0.3	-0.5	0.4	0.3
Peak expiratory flow (PEF)	0.0	0.0	0.1	-0.3	0.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.4	0.2	0.0
Body fat percentage	0.0	0.1	0.2	-0.3	0.4	0.3
Leg fat percentage (right)	0.0	0.0	0.0	-0.1	-0.2	-0.0
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.3	0.1	0.0
Leg fat percentage (left)	0.0	0.1	0.1	-0.2	-0.1	0.4
Pack years of smoking	0.0	0.0	0.0	-0.1	0.0	-0.2

Hub : Genes

GIMAP7

Models

Trait associations