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chr10:102,864,652-105,910,221

Best TWAS P=1.12e-22 · Best GWAS P=1.28e-22 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C10orf32	0.06	0.06	blup	54	0.08	1.2e-07	8.53	-9.8	1.1e-22	-0.80	0.36	0.64	TRUE
30	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-4.20	-9.7	2.3e-22	-0.58	0.03	0.57	TRUE
85	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	8.55	-8.7	4.9e-18	-0.79	0.16	0.83	TRUE
59	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	9.41	-8.0	9.0e-16	-0.77	0.05	0.95	TRUE
50	NTR	Blood	AS3MT	0.03	0.01	bslmm	351	0.02	4.4e-06	8.62	-7.8	4.4e-15	-0.54	0.77	0.20	TRUE
7	GTEx	Adipose Visceral Omentum	WBP1L	0.08	0.00	enet	13	0.01	8.1e-02	7.49	7.1	1.1e-12	0.38	0.14	0.09	TRUE
8	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	-2.66	-7.1	1.5e-12	-0.76	0.07	0.80	TRUE
38	GTEx	Nerve Tibial	RP11-18I14.10	0.05	0.01	enet	8	0.02	1.4e-02	6.65	-5.4	6.7e-08	-0.14	0.17	0.03	TRUE
93	The Cancer Genome Atlas	Skin Cutaneous Melanoma	BTRC	0.16	0.07	blup	89	0.09	2.2e-03	3.78	-5.2	2.3e-07	-0.01	0.09	0.25	TRUE
91	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	8.55	-9.8	1.2e-22	-0.83	0.03	0.64	FALSE
2	CommonMind	Brain Pre-frontal Cortex	AS3MT	0.17	0.16	lasso	9	0.15	4.5e-18	8.62	-9.6	1.0e-21	-0.71	0.96	0.04	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	9.34	-9.5	2.3e-21	-0.82	0.06	0.94	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	9.41	-9.4	6.1e-21	-0.82	0.03	0.96	FALSE
14	GTEx	Brain Cerebellar Hemisphere	NT5C2	0.15	0.10	enet	8	0.07	9.2e-03	9.04	-9.2	2.8e-20	-0.70	0.10	0.34	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	AS3MT	0.34	0.38	lasso	6	0.38	4.4e-46	8.53	-9.2	3.1e-20	-0.77	0.82	0.18	FALSE
46	METSIM	Adipose	AS3MT	0.24	0.28	lasso	12	0.28	6.1e-43	8.63	-9.1	7.3e-20	-0.75	1.00	0.00	FALSE
51	NTR	Blood	C10orf32	0.02	0.03	lasso	6	0.02	1.7e-08	8.63	-9.1	1.4e-19	-0.71	0.93	0.07	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C10orf32	0.21	0.21	enet	11	0.25	3.1e-28	8.62	-9.1	1.4e-19	-0.76	0.98	0.02	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C10orf32	0.11	0.16	lasso	4	0.15	1.4e-16	8.53	-9.1	1.4e-19	-0.75	0.91	0.09	FALSE
6	GTEx	Adipose Visceral Omentum	NT5C2	0.13	0.07	enet	12	0.08	5.0e-05	7.56	9.0	2.0e-19	0.54	0.82	0.12	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C10orf32	0.08	0.07	blup	54	0.07	4.2e-04	8.62	-9.0	2.1e-19	-0.70	0.22	0.33	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf32	0.27	0.27	enet	13	0.29	1.3e-28	8.53	-9.0	3.0e-19	-0.66	0.98	0.02	FALSE
64	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	8.53	-8.9	4.9e-19	-0.79	0.03	0.95	FALSE
3	CommonMind	Brain Pre-frontal Cortex	C10orf32	0.43	0.54	bslmm	348	0.54	2.2e-78	8.53	-8.8	1.5e-18	-0.66	1.00	0.00	FALSE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf32	0.18	0.19	lasso	4	0.19	4.1e-19	8.53	-8.8	1.7e-18	-0.70	0.98	0.02	FALSE
4	GTEx	Adipose Subcutaneous	NT5C2	0.09	0.05	lasso	2	0.04	6.5e-04	8.73	8.8	1.9e-18	0.51	0.95	0.01	FALSE
11	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	8.55	-8.8	1.9e-18	-0.77	0.07	0.80	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	C10orf32	0.27	0.09	lasso	8	0.17	7.3e-06	7.17	-8.7	4.5e-18	-0.65	0.08	0.74	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	C10orf32	0.14	0.21	enet	12	0.21	5.0e-24	8.62	-8.7	4.7e-18	-0.66	0.98	0.02	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	AS3MT	0.15	0.21	lasso	2	0.19	1.4e-08	8.62	-8.6	6.8e-18	-0.67	0.47	0.52	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	C10orf32	0.19	0.21	lasso	2	0.20	1.8e-14	8.53	-8.6	8.0e-18	-0.67	0.98	0.02	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf32	0.12	0.14	enet	6	0.14	8.2e-27	8.53	-8.6	1.0e-17	-0.66	0.98	0.02	FALSE
18	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	7.09	8.6	1.2e-17	0.70	0.06	0.83	FALSE
68	The Cancer Genome Atlas	Esophageal Carcinoma	C10orf32	0.19	0.25	enet	7	0.23	8.1e-08	8.63	-8.5	1.3e-17	-0.64	0.82	0.14	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C10orf32	0.18	0.16	enet	9	0.17	8.0e-19	8.53	-8.5	1.4e-17	-0.71	0.97	0.03	FALSE
13	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	8.55	8.5	1.5e-17	0.73	0.61	0.30	FALSE
82	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C10orf32	0.09	0.10	lasso	2	0.10	2.2e-07	8.53	-8.5	1.5e-17	-0.67	0.87	0.08	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	9.34	-8.5	1.7e-17	-0.77	0.07	0.93	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	C10orf32	0.21	0.19	lasso	6	0.19	2.2e-21	8.63	-8.5	2.3e-17	-0.60	0.98	0.02	FALSE
86	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C10orf32	0.30	0.29	lasso	3	0.28	1.8e-11	8.62	-8.5	2.7e-17	-0.67	0.94	0.06	FALSE
17	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	7.09	8.4	4.4e-17	0.58	0.08	0.83	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	8.39	-8.4	4.8e-17	-0.77	0.06	0.32	FALSE
84	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C10orf32	0.36	0.32	enet	10	0.32	8.3e-14	8.53	-8.3	1.2e-16	-0.60	0.98	0.02	FALSE
10	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	-0.25	8.2	1.6e-16	0.39	0.06	0.11	FALSE
16	GTEx	Brain Cerebellum	NT5C2	0.23	0.15	lasso	4	0.09	1.4e-03	9.04	-8.2	1.6e-16	-0.71	0.14	0.52	FALSE
19	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	6.69	8.2	2.0e-16	0.77	0.04	0.73	FALSE
12	GTEx	Artery Tibial	WBP1L	0.07	0.06	lasso	5	0.03	9.7e-04	7.51	8.2	2.4e-16	0.63	0.69	0.06	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	NT5C2	0.14	0.13	lasso	5	0.12	4.4e-12	8.78	-8.1	6.3e-16	-0.76	0.99	0.01	FALSE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	8.53	-8.1	6.4e-16	-0.82	0.02	0.75	FALSE
34	GTEx	Muscle Skeletal	SFXN2	0.07	0.02	lasso	3	0.03	4.6e-04	7.51	8.0	1.9e-15	0.52	0.28	0.06	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	8.39	-7.9	2.0e-15	-0.78	0.16	0.84	FALSE
47	METSIM	Adipose	C10orf32	0.20	0.24	lasso	6	0.26	2.2e-38	8.63	-7.8	4.2e-15	-0.67	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	9.41	-7.8	4.2e-15	-0.72	0.05	0.95	FALSE
28	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-3.11	-7.8	6.1e-15	-0.57	0.34	0.41	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	AS3MT	0.44	0.40	enet	15	0.45	2.1e-63	8.62	-7.8	8.9e-15	-0.66	1.00	0.00	FALSE
41	GTEx	Pancreas	CYP17A1-AS1	0.11	0.06	lasso	5	0.06	1.1e-03	9.41	7.7	1.6e-14	0.73	0.06	0.60	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	7.09	7.6	2.8e-14	0.64	0.07	0.63	FALSE
27	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-4.36	-7.6	3.3e-14	-0.42	0.62	0.18	FALSE
44	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	-3.44	-7.4	1.5e-13	-0.32	0.07	0.08	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	6.94	7.3	2.8e-13	0.62	0.22	0.13	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	C10orf32	0.34	0.25	blup	54	0.32	1.1e-18	8.53	-7.2	4.2e-13	-0.47	0.99	0.01	FALSE
45	METSIM	Adipose	ARL3	0.04	0.00	bslmm	364	0.01	1.4e-02	3.29	7.1	1.1e-12	0.18	0.14	0.11	FALSE
33	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	6.94	7.1	1.2e-12	0.65	0.70	0.10	FALSE
36	GTEx	Nerve Tibial	SFXN2	0.30	0.22	lasso	11	0.22	1.7e-15	7.05	7.1	1.7e-12	0.37	1.00	0.00	FALSE
37	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	6.96	7.0	2.8e-12	0.63	0.45	0.30	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C10orf32	0.36	0.21	blup	54	0.23	1.6e-13	8.53	-6.9	3.9e-12	-0.49	0.98	0.02	FALSE
31	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-4.23	-6.9	5.6e-12	-0.46	0.64	0.20	FALSE
92	The Cancer Genome Atlas	Soft Tissue Sarcoma	C10orf32	0.07	0.03	blup	52	0.03	6.4e-03	8.53	-6.8	1.3e-11	-0.57	0.05	0.20	FALSE
40	GTEx	Pancreas	TRIM8	0.32	0.17	lasso	6	0.19	1.9e-08	7.49	-6.5	8.1e-11	-0.41	0.94	0.00	FALSE
32	GTEx	Liver	CALHM2	0.20	0.01	enet	34	0.08	2.9e-03	8.72	-6.5	8.7e-11	-0.59	0.04	0.43	FALSE
48	METSIM	Adipose	PDCD11	0.04	0.02	bslmm	367	0.02	9.4e-04	-4.48	6.3	3.0e-10	0.33	0.20	0.13	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	SFXN2	0.05	0.04	lasso	2	0.05	1.3e-06	7.29	6.3	3.7e-10	0.51	0.58	0.11	FALSE
15	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	-5.33	6.2	5.1e-10	0.51	0.10	0.19	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	7.09	6.2	6.2e-10	0.63	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	5.04	6.2	7.9e-10	0.26	0.02	0.57	FALSE
5	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	-3.89	5.7	1.3e-08	0.27	0.10	0.21	FALSE
21	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	6.68	5.7	1.3e-08	0.59	0.14	0.27	FALSE
42	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-4.57	5.7	1.4e-08	0.34	0.91	0.01	FALSE
58	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-3.90	5.7	1.4e-08	0.29	1.00	0.00	FALSE
24	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	2.36	5.7	1.5e-08	0.56	0.07	0.14	FALSE
23	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-3.87	-5.6	2.4e-08	-0.28	0.20	0.37	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-4.25	5.5	3.5e-08	0.37	0.21	0.12	FALSE
43	GTEx	Thyroid	SFXN2	0.28	0.06	enet	32	0.15	1.1e-11	-2.45	-5.5	4.3e-08	-0.58	1.00	0.00	FALSE
52	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	-3.11	5.5	4.7e-08	0.34	0.78	0.01	FALSE
65	The Cancer Genome Atlas	Colon Adenocarcinoma	AS3MT	0.09	0.02	lasso	3	0.01	8.1e-02	2.77	-5.5	4.9e-08	-0.61	0.08	0.58	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRIM8	0.06	0.03	lasso	6	0.06	1.9e-06	-2.86	-5.4	6.0e-08	-0.30	0.48	0.32	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-2.70	5.4	6.1e-08	0.50	0.55	0.05	FALSE
39	GTEx	Pancreas	SFXN2	0.66	0.32	enet	54	0.33	8.7e-15	-1.56	5.4	7.8e-08	0.11	1.00	0.00	FALSE
49	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-3.11	5.3	9.0e-08	0.41	1.00	0.00	FALSE
35	GTEx	Muscle Skeletal	WBP1L	0.04	0.00	enet	26	0.02	1.8e-03	7.56	5.3	1.1e-07	0.47	0.09	0.19	FALSE
57	YFS	Blood	ARL3	0.39	0.14	enet	30	0.20	7.0e-63	1.59	5.3	1.1e-07	0.44	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AS3MT	0.04	0.02	enet	6	0.02	1.9e-03	2.73	-5.3	1.2e-07	-0.66	0.02	0.70	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-5.19	-5.3	1.3e-07	-0.39	0.91	0.00	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	INA	0.12	0.05	lasso	6	0.06	2.3e-08	-1.91	-5.2	1.5e-07	-0.13	1.00	0.00	FALSE
22	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-5.09	5.2	2.0e-07	0.49	0.04	0.05	FALSE
9	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	-3.44	-5.2	2.3e-07	-0.36	0.19	0.29	FALSE
29	GTEx	Heart Atrial Appendage	MIR1307	0.61	0.62	enet	7	0.63	2.0e-35	-4.36	-5.1	3.0e-07	-0.20	1.00	0.00	FALSE