TWAS hub - DPEP3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0133	0.0056	4.4e-06	0.006	0.017	0.012	0.015	0.011	0.0048	2.8e-06	8.4e-05	7.7e-06	0.00015
2	TCGA	Prostate Adenocarcinoma	0.0386	0.0268	3.5e-03	0.025	0.026	0.024	NA	0.020	0.0011	9.0e-04	1.5e-03	NA	0.00290

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
HDL Cholesterol	40.1	66.8	84.3	-9.2	-7.0
Lung FEV1/FVC ratio	14.8	75.3	97.5	-7.3	-9.9
Medication: Seretide 50 evohaler	13.8	15.9	18.4	4.3	3.7
Blood Red Count	13.1	126.7	134.6	-11.6	-10.9
Ovarian Cancer	9.2	12.2	14.2	3.8	3.2
Fasting Glucose	7.3	8.8	10.4	3.2	2.7
Hypothyroidism (self reported)	7.1	16.3	25.9	-2.6	-5.1
Schizophrenia (2014)	6.2	13.6	16.8	-3.2	-4.1
Bipolar Disorder or Schizophrenia	5.8	14.2	19.9	-2.9	-4.5
Schizophrenia (2018)	5.4	11.3	16.4	-2.5	-4.1
Emphysema/chronic bronchitis	5.4	6.1	9.2	3.0	1.7
Primary Biliary Cirrhosis	5.3	7.6	11.0	-3.3	-2.1
Bipolar Disorder (2011)	5.1	4.9	6.8	-1.8	-2.6
Birth weight	5.1	11.1	13.7	3.7	2.9
Average weekly champagne plus white wine intake	4.9	6.8	8.7	-2.9	-2.2
Hypothyroidism/myxoedema (self-reported)	4.7	9.1	15.3	-1.7	-3.9
Number of full brothers	4.5	5.7	6.6	2.6	2.2
Bilateral oophorectomy (both ovaries removed)	4.1	4.7	7.3	-2.7	-1.5
Hair/balding pattern: Pattern 4	4.1	9.9	19.7	-0.4	4.4
Ever unenthusiastic/disinterested for a whole week	3.9	4.8	6.8	-1.6	-2.6
Average weekly spirits intake	3.8	4.7	6.4	2.5	1.7
Chest pain or discomfort	3.7	5.4	9.4	3.1	1.1
Deep venous thrombosis (DVT) (self-reported)	3.7	4.8	4.9	-2.2	-2.2
Frequency of tenseness / restlessness in last 2 weeks	3.5	5.4	6.6	-2.1	-2.6
Average weekly red wine intake	3.4	5.1	8.0	2.8	1.5
Schizophrenia vs Biploar Disorder	3.3	4.4	6.7	-2.6	-1.4
Lupus	3.3	5.0	5.5	-2.1	-2.3
Intelligence (Savage-Jansen 2018)	3.2	9.7	16.2	1.8	4.0
Blood clot in the leg (DVT)	3.2	4.1	4.3	-2.1	-2.0
Comparative body size at age 10	3.2	8.9	17.9	-4.2	0.0
Pulse wave peak to peak time	3.2	3.8	4.9	2.2	1.6
Pulse wave Arterial Stiffness index	3.1	3.6	6.0	-2.4	-1.1
Mood swings	3.1	5.6	7.8	-1.9	-2.8
Asthma (self-reported)	3.1	6.3	10.4	3.2	1.5
Allergy or Eczema	3.0	7.9	13.1	3.6	1.6
Chronotype (morning person)	3.0	7.0	13.6	0.7	3.7
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.4	4.9	1.4	2.2
Respiratory disease	2.9	6.4	10.3	3.2	1.6
Fluid intelligence score	2.9	6.0	9.8	1.5	3.1
Falls in the last year	2.9	3.9	4.6	1.8	2.1
Prospective memory result	2.9	3.5	4.4	-2.1	-1.6
Asthma	2.7	5.4	9.4	3.1	1.2
Suffer from ‘nerves’	2.7	4.2	8.1	-0.6	-2.9
Stomach or abdominal pain in last month	2.6	3.2	3.6	-1.7	-1.9
Forced vital capacity (FVC)	2.6	10.2	18.3	1.5	4.3
Eye problems/disorders: None of the above	2.6	3.0	3.6	1.6	1.9
Osteoporosis (self-reported)	2.6	3.2	4.7	2.2	1.3
Irritability	2.6	4.5	5.6	-1.8	-2.4
Verbal and Numeric Reasoning (VNR)	2.5	5.9	9.2	1.6	3.0
Ever depressed for a whole week	2.5	3.1	3.9	-2.0	-1.5
Diabetes (father)	2.4	2.9	4.3	-2.1	-1.3
Neck or shoulder pain in last month	2.4	3.4	4.1	-2.0	-1.6
Myopia	2.3	3.4	5.2	-1.3	-2.3
Alcohol drinker status: Previous	2.3	2.7	3.1	-1.5	-1.8
Waist Hip Ratio (WHR)	2.2	9.7	14.8	2.1	3.9
Medication: Levothyroxine sodium	2.2	3.7	7.2	-0.5	-2.7
Medication: Lisinopril	2.2	2.9	4.7	1.0	2.2
Bipolar Disorder (2018)	2.1	3.3	4.1	-1.6	-2.0
Lung FVC	2.1	10.4	14.6	2.5	3.8
Qualifications: CSEs or equivalent	2.1	2.8	5.5	-0.4	-2.3
Medication: Atenolol	2.1	2.6	5.0	-2.2	0.5
Basal cell carcinoma (self-reported)	2.1	2.5	3.8	1.9	1.1
Migraine (self-reported)	2.0	2.5	4.7	-2.2	-0.5
Smoking status: Previous	2.0	3.0	5.9	0.4	-2.4
Diabetes (mother)	1.9	2.4	4.6	-0.5	-2.1
Forced vital capacity (FVC), Best measure	1.9	7.1	12.7	1.2	3.6
Qualifications: College or University degree	1.9	6.1	12.1	-0.2	3.5
Osteoarthritis (self-reported)	1.9	2.4	2.6	-1.6	-1.5
Medication: Co-codamol	1.8	2.1	2.2	-1.4	-1.5
Trunk fat percentage	1.8	7.1	13.8	-3.7	-0.6
Trunk fat mass	1.8	7.8	15.3	-3.9	0.6
Alcohol usually taken with meals	1.8	3.0	4.2	-1.3	-2.0
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.5	2.1	0.3
Chronic bronchitis/emphysema (mother)	1.8	2.1	3.3	0.9	-1.8
Wheeze or whistling in the chest in last year	1.8	3.3	6.4	2.5	0.4
Had major operations	1.8	2.1	2.7	1.2	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	4.2	-0.1	2.1
Eye problems/disorders: Cataract	1.8	2.1	2.5	-1.3	-1.6
Illnesses of father: High blood pressure	1.8	2.2	2.7	-1.3	-1.6
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.3	-1.1	-1.8
Worry (Nagel 2018)	1.7	3.6	6.9	-0.5	-2.6
Breast Cancer	1.7	4.0	4.2	2.0	2.0
Supplements: Glucosamine	1.7	2.2	4.2	0.4	2.0
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	4.5	2.1	0.2
Hair/balding pattern: Pattern 3	1.7	2.6	4.2	2.1	1.0
Gout (self-reported)	1.7	2.4	4.0	2.0	-0.9
Whole body fat mass	1.7	7.3	14.4	-3.8	0.4
Hearing aid user	1.7	2.0	2.2	1.5	1.3
Leg fat mass (left)	1.7	6.5	12.7	-3.6	0.5
Prostate Cancer	1.6	2.2	2.7	1.6	1.3
Nervous feelings	1.6	3.1	5.9	0.4	-2.4
Time employed in main current job	1.6	1.8	3.6	0.0	-1.9
Alcohol intake versus 10 years previously	1.6	2.3	3.8	-0.9	1.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.0	-2.0	-0.5
Arm fat mass (left)	1.6	6.4	12.6	-3.5	0.4
Medication: Blood pressure	1.6	3.1	4.8	-2.2	-1.2
Number of operations (self-reported)	1.6	2.3	2.6	-1.6	-1.4
Pain experienced in last month	1.6	2.7	3.9	2.0	1.2
Depression (Nagel 2018)	1.5	2.2	3.5	-0.9	-1.9
Neuroticism (Nagel 2018)	1.5	3.6	6.5	-0.8	-2.5
Crohns Disease (2017)	1.5	3.3	4.9	1.3	2.2
Allergy	1.5	3.5	7.0	-2.6	0.1
Arm fat mass (right)	1.5	6.0	11.8	-3.4	0.4
Standing height	1.5	14.4	22.6	-2.5	4.8
Body fat percentage	1.5	6.0	11.7	-3.4	-0.5
Alcohol intake frequency.	1.5	3.5	5.8	-1.1	-2.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.4	-0.6	-1.9
Ever smoked	1.5	2.7	3.9	-1.2	-2.0
Supplements: Zinc	1.4	1.6	2.9	-0.5	-1.7
Hayfever, allergic rhinitis or eczema	1.4	3.1	6.2	2.5	0.2
Neuroticism (2016)	1.3	1.9	3.2	-0.8	-1.8
Rheumatoid Arthritis	1.3	1.8	2.5	1.6	1.0
Frequency of depressed mood in last 2 weeks	1.3	1.9	3.0	-0.9	-1.7
Hearing difficulty/problems: Yes	1.3	2.0	3.8	2.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	3.3	-0.5	-1.8
Heart attack	1.3	1.6	2.6	-0.8	-1.6
Weight	1.3	6.2	8.9	-3.0	1.9
Arm fat percentage (right)	1.3	5.0	9.4	-3.1	-0.8
Trunk fat-free mass	1.3	7.7	12.1	-1.8	3.5
Father’s age at death	1.3	1.8	2.2	-1.5	-1.1
Trunk predicted mass	1.3	7.6	12.2	-1.8	3.5
Medication: Blood pressure	1.3	2.3	3.5	1.1	1.9
Leg fat mass (right)	1.3	5.2	9.7	-3.1	0.9
Comparative height size at age 10	1.3	7.1	7.7	-2.8	2.5
Leg fat percentage (left)	1.3	4.6	8.8	-3.0	-0.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.5	-0.2	-1.6
Multivitamins +/- minerals	1.2	1.5	1.8	-1.0	-1.4
Waist circumference	1.2	4.3	5.3	-1.8	2.3
Had other major operations	1.2	1.4	2.4	-0.6	-1.6
Arm fat percentage (left)	1.2	4.8	9.4	-3.1	-0.6
High cholesterol (Self-reported)	1.2	2.0	2.7	-1.2	-1.6
Basal metabolic rate	1.2	6.5	7.6	-2.4	2.8
Arm fat-free mass (left)	1.2	6.3	6.3	-2.5	2.5
Arm predicted mass (left)	1.2	6.1	6.1	-2.5	2.5
Heel T-Score	1.1	8.5	16.1	-0.9	-4.0
Neuroticism	1.1	2.7	4.7	-0.8	-2.2
Serious illness, injury or assault to yourself	1.1	1.3	2.6	0.2	1.6
Hair/balding pattern: Pattern 2	1.1	1.4	2.7	-1.6	-0.2
Neuroticism score	1.1	2.4	4.7	-0.0	-2.2
Ever highly irritable/argumentative for 2 days	1.1	1.4	2.6	-1.6	-0.4
Arm fat-free mass (right)	1.1	5.4	6.4	-2.1	2.5
Medication: Allopurinol	1.1	1.5	3.0	1.7	0.1
Heart disease (mother)	1.1	1.4	2.3	-1.5	-0.7
Arm predicted mass (right)	1.1	5.8	5.9	-2.4	2.4
Supplements: Vitamin C	1.1	1.2	2.3	-0.4	-1.5
Whole body fat-free mass	1.1	6.1	8.0	-2.1	2.8
Medication for cholesterol	1.1	1.7	2.9	1.7	0.7
Back pain experienced in last month	1.1	1.6	2.7	-1.6	-0.7
Mineral and other dietary supplements	1.1	1.5	2.8	-0.3	-1.7
Average weekly beer plus cider intake	1.1	1.6	1.7	1.3	1.2
Diastolic blood pressure, automated reading	1.1	3.4	6.0	-2.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.6	-1.6	-0.1
Height	1.0	19.4	26.6	-3.5	5.2
Current tobacco smoking	1.0	1.6	2.9	-0.5	1.7
Medication: Simvastatin	1.0	1.5	2.6	-1.6	-0.5
Mouth/teeth dental problems: Dentures	1.0	1.6	2.7	1.6	-0.7
Qualifications: nursing, teaching	1.0	1.5	2.4	-0.8	-1.5
Whole body water mass	1.0	6.0	7.4	-2.1	2.7
Mother’s age at death	1.0	1.2	2.2	-1.5	-0.5
Alcohol drinker status: Never	1.0	1.2	1.7	1.3	-0.8
Major Depression (MDD)	0.9	1.1	2.3	-1.5	0.1
Coronary Artery Disease (CAD)	0.9	1.0	1.3	0.9	1.1
Lung cancer (father)	0.9	1.1	1.3	-0.9	-1.1
Tense / ‘highly strung’	0.9	1.4	2.2	-0.8	-1.5
Age at last live birth	0.9	1.2	1.8	-1.4	0.8
Family relationship satisfaction	0.9	1.1	1.5	-0.9	1.2
Smoking status: Current	0.9	1.4	2.6	-0.3	1.6
Supplements: Calcium	0.9	1.0	2.0	1.4	0.2
Mean Putamen Volume	0.8	1.0	1.4	1.2	-0.7
Number of treatments/medications taken	0.8	1.5	1.8	-1.4	-1.1
Sensitivity / hurt feelings	0.8	1.3	2.4	-1.6	-0.5
Leg fat-free mass (left)	0.8	4.4	5.3	-1.9	2.3
Leg predicted mass (left)	0.8	4.4	5.2	-1.9	2.3
Exposure to tobacco smoke at home	0.8	0.8	1.1	1.1	-0.8
Number of full sisters	0.8	1.0	1.8	0.4	1.3
Illnesses of siblings: Diabetes	0.8	1.0	1.7	1.3	-0.6
Loneliness, isolation	0.8	1.1	2.1	-0.4	-1.4
Medication: Aspirin	0.8	1.0	1.0	-1.0	-1.0
Medication: Bendroflumethiazide	0.8	1.3	1.4	-1.1	1.2
Depressed Affect (Nagel 2018)	0.7	1.6	2.7	-0.6	-1.6
Irritable Bowel Disease (IBD)	0.7	1.7	1.8	1.3	1.4
Body Mass Index (BMI) (2010)	0.7	1.0	2.0	-1.4	-0.1
BMI	0.7	4.0	7.9	-2.8	-0.1
Vitamin and mineral supplements	0.7	0.9	1.7	0.3	1.3
Fed-up feelings	0.7	1.2	2.4	-0.1	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	0.9	1.0	-0.9
Sitting height	0.7	4.7	8.5	-2.9	0.9
High blood pressure (mother)	0.7	1.0	1.7	-0.5	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.2	-1.1	-1.0
Birth weight of first child	0.7	1.2	2.4	1.6	0.2
Leg fat percentage (right)	0.7	2.6	5.3	-2.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	1.4	0.6	-1.2
Leg fat-free mass (right)	0.7	3.5	3.6	-1.9	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.5	1.2	0.4
Leg predicted mass (right)	0.7	3.6	3.6	-1.9	1.9
Wears glasses or contact lenses	0.7	0.8	1.3	-1.1	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.9	0.9	0.9	-0.9
Cholesterol lowering medication	0.7	1.0	1.4	-1.2	-0.8
Average weekly fortified wine intake	0.6	0.8	1.4	1.2	0.3
Past tobacco smoking	0.6	1.1	2.3	-0.1	1.5
Medication: Cholesterol lowering	0.6	1.0	1.6	-0.6	-1.3
Headache pain in last month	0.6	1.1	2.2	-1.5	-0.1
Medication: Amlodipine	0.6	0.8	1.2	1.1	-0.6
Medication: Ibuprofen	0.6	0.7	1.3	-0.3	-1.1
Medication: Omeprazole	0.6	0.7	1.5	-1.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.0	-0.8	1.4
Breast cancer (self-reported)	0.6	0.7	0.9	0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.8	-1.3	-0.9
Age at First Birth	0.5	0.7	0.9	0.7	0.9
HbA1C	0.5	0.5	1.0	-1.0	0.2
Triglycerides	0.5	0.9	1.0	0.8	1.0
Blood Platelet Count	0.5	6.2	6.3	-2.5	2.5
Hair Pigment	0.5	12.9	17.9	-2.8	-4.2
Pack years adult smoking proportion	0.5	0.8	1.3	0.5	1.1
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.2	-0.0
Taking other prescription medications	0.5	0.8	1.6	0.1	-1.2
Body mass index (BMI)	0.5	2.3	4.6	-2.1	-0.3
Mouth/teeth dental problems	0.5	0.7	1.0	-1.0	0.7
Hip circumference	0.5	2.3	4.1	-2.0	0.7
Pulse rate	0.5	0.8	1.3	-1.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.1	0.5	1.4
Peak expiratory flow (PEF)	0.5	1.2	1.9	-1.4	-0.7
Medication: Paracetamol	0.5	0.8	1.4	-0.5	1.2
Worry too long after embarrassment	0.5	0.9	1.8	0.2	-1.3
Shortness of breath walking on level ground	0.5	0.6	0.7	0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	0.7	0.8	0.8
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	0.7	0.8
Guilty feelings	0.5	0.7	1.4	1.2	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	1.1	-0.2
Commuting to job workplace: Public transport	0.5	0.7	1.1	-0.4	1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.1	1.0	0.4
Pack years of smoking	0.5	0.7	1.3	0.4	1.1
Reaction Time	0.4	0.8	1.6	-1.3	0.0
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.8	0.4
Number of incorrect matches in round	0.4	0.6	1.0	-0.4	-1.0
Happiness	0.4	0.5	1.0	-0.3	1.0
Medication: Lansoprazole	0.4	0.4	0.8	-0.9	-0.3
Illnesses of mother	0.4	0.5	0.9	0.9	0.4
Exposure to tobacco smoke outside home	0.4	0.6	0.9	0.5	-0.9
Number of children fathered	0.4	0.4	0.6	0.8	0.6
Age at first live birth	0.4	0.8	1.5	0.0	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	0.5	-0.9
Angina (self-reported)	0.4	0.5	0.6	0.8	0.6
Leg pain on walking	0.4	0.5	0.8	0.3	0.9
Knee pain experienced in last month	0.4	0.6	1.1	-0.4	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.6	0.7	0.7
Ever had bowel cancer screening	0.4	0.5	0.6	0.6	0.7
Medication: Gliclazide	0.4	0.5	1.0	-0.3	-1.0
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.9	-0.0
Alzheimer’s Disease (in father)	0.3	0.4	0.7	0.3	-0.8
Crohns Disease (2012)	0.3	0.6	1.1	0.2	1.0
Blood Eosinophil Count	0.3	2.0	3.8	0.4	-1.9
Blood White Count	0.3	2.3	4.5	0.3	2.1
Angina	0.3	0.4	0.5	0.7	0.6
Severe depression (siblings)	0.3	0.3	0.5	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.7	-0.7	-0.8
Qualifications: None of the above	0.3	0.7	1.3	1.1	-0.4
Worrier / anxious feelings	0.3	0.5	1.1	0.0	-1.0
Number of live births	0.3	0.4	0.6	-0.8	-0.4
Breastfed as a baby	0.3	0.3	0.6	0.8	0.2
Pulse wave reflection index	0.3	0.3	0.5	-0.7	-0.4
Mean time to correctly identify matches	0.3	0.6	0.8	-0.9	-0.6
Medication: Aspirin	0.3	0.4	0.4	-0.7	-0.5
Risk taking	0.3	0.4	0.8	0.1	0.9
Fractured/broken bones in last 5 years	0.3	0.3	0.4	-0.5	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.2	-0.5	0.4
Ulcerative Colitis	0.2	0.3	0.6	0.8	0.1
Smoking Status	0.2	0.6	0.7	-0.7	-0.8
Cardiovascular Disease	0.2	0.5	0.7	-0.8	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.7	0.2
Maternal smoking around birth	0.2	0.3	0.5	-0.0	0.7
Impedance of leg (left)	0.2	0.8	1.2	-1.1	-0.6
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	0.3
Impedance of arm (right)	0.2	0.9	0.9	-0.9	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.6	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.8	-0.9	0.8
Noisy workplace	0.2	0.2	0.4	-0.2	-0.6
Loud music exposure frequency	0.2	0.2	0.4	-0.6	-0.1
High blood pressure (siblings)	0.2	0.3	0.6	-0.8	-0.0
Overall health rating	0.2	0.5	0.6	-0.8	-0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.3	-0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	-0.7	-0.2
Miserableness	0.2	0.3	0.7	0.1	-0.8
Financial situation satisfaction	0.2	0.3	0.6	0.2	0.8
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.7	-0.3
Unable to work because of sickness or disability	0.2	0.2	0.4	0.7	0.0
Heart disease (siblings)	0.2	0.3	0.6	0.1	-0.7
LDL Cholesterol	0.1	0.1	0.2	0.3	-0.4
Tanning	0.1	0.6	1.2	-1.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.3	0.3
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.1	0.7
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	0.2
Medication: Metformin	0.1	0.1	0.1	0.3	-0.3
Hand grip strength (right)	0.1	0.2	0.4	-0.6	-0.2
Relative age voice broke	0.1	0.2	0.3	-0.5	0.3
Age when periods started (menarche)	0.1	0.3	0.7	-0.8	0.1
High blood pressure	0.1	0.2	0.2	-0.3	0.5
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.3	0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.5	-0.4
Had menopause	0.1	0.2	0.4	-0.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.1	-0.6
Pain all over the body in last month	0.1	0.1	0.2	-0.0	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	0.6	-0.6	0.7
Impedance of arm (left)	0.1	0.6	0.9	-0.6	-0.9
Length of working week for main job	0.1	0.1	0.1	-0.3	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.2	-0.4	-0.5
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.3	0.3
Health satisfaction	0.1	0.1	0.3	-0.5	-0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.6	0.2
Pulse rate, automated reading	0.1	0.2	0.4	-0.3	-0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.5	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.3	-0.4
Friendships satisfaction	0.1	0.1	0.3	0.1	0.5
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.1	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.3	-0.5
Medication: Paracetamol	0.1	0.2	0.4	-0.2	0.6
Medication: Atorvastatin	0.1	0.2	0.2	0.3	0.5
Age started oral contraceptive pill	0.1	0.1	0.2	0.5	0.2
Impedance of whole body	0.1	0.5	0.7	-0.6	-0.8
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.1	-0.1
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.2	-0.0
Systolic Blood Pressure	0.0	0.2	0.3	0.3	0.5
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.1	0.3
Hand grip strength (left)	0.0	0.1	0.1	0.1	0.3
Relative age of first facial hair	0.0	0.1	0.1	-0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	-0.2
Impedance of leg (right)	0.0	0.1	0.1	-0.2	0.4
Diabetes (self-reported)	0.0	0.0	0.0	-0.1	0.0
Medication: Ramipril	0.0	0.0	0.1	0.0	0.2
Illnesses of siblings	0.0	0.0	0.0	-0.2	0.2
Depression (self-reported)	0.0	0.0	0.1	0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.2	0.0
Hypertension (Self-reported)	0.0	0.1	0.1	-0.4	0.3
Illnesses of father: Heart disease	0.0	0.1	0.1	-0.3	-0.2
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.0	-0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.5	-0.1

Hub : Genes

DPEP3

Models

Trait associations