Hub : Genes

PARD6A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hippocampus 0.465 0.1253 0.0016 0.000 NA 0.019 NA 0.024 0.32000 NA 0.110 NA 0.08800
2 GTEx Breast Mammary Tissue (Male) 0.151 0.0966 0.0480 0.025 NA -0.012 NA 0.031 0.08600 NA 0.750 NA 0.06600
3 GTEx Pancreas 0.084 0.0470 0.0028 0.092 NA 0.041 NA 0.078 0.00011 NA 0.008 NA 0.00033

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.2 3.6 -0.1 0.0 -1.9
Bipolar Disorder or Schizophrenia 2.9 7.0 13.7 -2.4 1.2 -3.7
Depressed Affect (Nagel 2018) 0.4 0.9 1.5 0.6 0.8 -1.2
Depression (Nagel 2018) 0.9 1.3 2.7 -1.0 0.3 -1.7
Intelligence (Savage-Jansen 2018) 1.1 3.2 8.6 1.0 -0.2 2.9
Neuroticism (Nagel 2018) 0.8 1.9 5.2 0.5 0.5 -2.3
Schizophrenia (2018) 3.5 7.3 10.3 -3.0 1.6 -3.2
Schizophrenia vs Biploar Disorder 0.7 0.9 1.0 -0.8 1.0 -1.0
Worry (Nagel 2018) 1.1 2.3 6.7 -0.1 0.6 -2.6
Alzheimer’s Disease (in mother) 0.5 0.6 1.0 -1.0 -0.8 0.2
Alzheimer’s Disease (in father) 0.9 1.0 2.9 0.2 -0.2 -1.7
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 -0.4 -0.8 -0.7
Crohns Disease (2017) 1.3 2.9 4.8 1.4 -1.4 2.2
Irritable Bowel Disease (IBD) 0.2 0.5 1.0 0.3 -1.0 0.7
Ulcerative Colitis (UC) 0.5 0.9 1.3 -1.2 0.3 -1.2
Major Depression (MDD) 0.3 0.4 0.9 -0.4 -0.9 -0.4
Reaction Time 0.4 0.7 1.0 -1.0 -0.8 -0.7
Verbal and Numeric Reasoning (VNR) 1.4 3.3 6.8 1.7 -0.5 2.6
Breast Cancer 0.4 0.9 2.6 -0.4 0.1 1.6
Ovarian Cancer 4.0 5.3 12.7 1.7 -0.4 3.6
Prostate Cancer 1.6 2.3 5.7 0.6 -0.9 2.4
Age at First Birth 0.2 0.3 0.6 -0.6 -0.0 0.8
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 0.1 -0.1 -0.0
Coronary Artery Disease (CAD) 1.7 2.0 3.5 1.1 -1.1 1.9
Crohns Disease (2012) 0.9 1.5 3.0 0.8 -0.9 1.7
Mean Putamen Volume 0.2 0.2 0.4 0.6 0.5 0.1
Fasting Glucose 3.6 4.3 6.9 1.8 -1.7 2.6
HbA1C 0.2 0.2 0.5 0.1 -0.7 0.3
HDL Cholesterol 24.5 40.8 74.1 -7.0 -0.1 -8.6
LDL Cholesterol 0.2 0.4 0.9 -0.9 -0.5 -0.2
Lupus 2.7 4.1 5.5 -2.4 1.5 -2.1
Neuroticism (2016) 0.6 0.9 2.5 0.2 0.1 -1.6
Primary Biliary Cirrhosis 1.2 1.6 3.4 -1.2 0.0 -1.9
Rheumatoid Arthritis 0.7 0.9 2.8 1.7 -0.1 0.1
Schizophrenia (2014) 2.6 5.7 9.0 -2.6 1.1 -3.0
Triglycerides 0.3 0.5 1.3 0.4 -0.1 1.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.3 1.1 -0.5 0.7
Ulcerative Colitis 0.2 0.3 0.4 -0.7 -0.5 -0.5
Blood Eosinophil Count 0.1 0.8 1.4 1.2 -0.6 -0.9
Blood Platelet Count 0.2 2.5 4.4 0.7 -2.1 1.6
Blood Red Count 6.0 57.9 125.4 -5.7 3.9 -11.2
Blood White Count 1.1 8.3 17.1 1.1 -4.1 2.5
Heel T-Score 2.7 21.2 36.6 -6.0 4.2 -3.1
BMI 0.2 1.3 2.1 1.4 -1.0 -0.8
Height 0.5 10.0 18.3 1.8 -2.9 4.3
Waist Hip Ratio (WHR) 1.2 5.5 13.5 0.3 -1.7 3.7
Systolic Blood Pressure 0.1 0.7 1.3 1.1 0.8 -0.4
Smoking Status 0.2 0.5 1.0 0.2 0.7 -1.0
Allergy or Eczema 0.7 1.7 3.0 1.5 0.3 1.7
Cardiovascular Disease 0.1 0.5 1.2 -0.4 -1.1 -0.1
Hypothyroidism (self reported) 3.2 7.4 15.6 -1.2 2.3 -4.0
Respiratory disease 0.5 1.1 2.6 0.2 -0.8 1.6
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.3 0.3 -0.6 0.2
Lung FEV1/FVC ratio 7.5 38.2 92.4 -2.1 4.2 -9.6
Lung FVC 1.1 5.5 12.1 0.8 -1.9 3.5
Neuroticism 1.0 2.5 6.3 0.4 1.0 -2.5
Chronotype (morning person) 3.0 7.0 8.4 2.2 -2.8 2.9
Hair Pigment 0.4 11.5 23.8 -2.8 1.7 -4.9
Tanning 0.0 0.4 0.6 -0.8 -0.4 0.7
Hand grip strength (left) 0.3 0.9 2.5 1.6 0.1 0.3
Number of treatments/medications taken 0.7 1.3 3.3 -1.8 -0.3 -0.8
Average weekly spirits intake 1.5 1.9 4.1 1.2 -0.2 2.0
Sensitivity / hurt feelings 0.2 0.3 0.7 -0.4 -0.9 -0.4
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.9 -0.8 0.6 -1.7
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.4 -0.4 0.6
Relative age of first facial hair 0.1 0.1 0.3 -0.4 0.5 -0.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 0.6 -0.2 -0.8 0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.7 0.9 -0.8 -0.7 1.0
Ever had hysterectomy (womb removed) 0.7 0.8 1.3 1.1 -1.1 0.0
Systolic blood pressure, automated reading 0.3 0.8 2.3 1.5 0.4 0.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.2 -1.5 0.4 0.3
Angina 0.6 0.8 1.8 1.3 -0.7 0.3
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.6 -0.2 -0.1
Vitamin and mineral supplements 1.1 1.5 1.7 1.0 -1.3 1.3
Supplements: Zinc 1.5 1.6 4.5 0.2 0.4 -2.1
Medication: Co-codamol 0.4 0.5 0.8 -0.7 0.2 -0.9
Medication: Metformin 0.1 0.2 0.5 0.4 0.7 0.0
Diabetes (father) 1.0 1.3 3.0 -0.0 1.7 -0.9
Diabetes (mother) 0.2 0.3 0.5 -0.1 -0.5 -0.7
Severe depression (siblings) 0.6 0.7 2.1 1.4 0.1 -0.2
Pack years adult smoking proportion 1.0 1.5 2.8 0.4 -1.2 1.7
Impedance of leg (right) 0.5 2.3 3.7 -1.4 -1.9 1.1
Leg fat-free mass (left) 0.4 2.2 4.2 2.1 -0.8 1.3
Trunk fat percentage 0.3 1.1 2.9 -0.5 -1.7 -0.3
Hand grip strength (right) 0.4 1.0 2.1 1.4 1.0 -0.3
Townsend deprivation index at recruitment 0.5 0.7 1.5 -0.3 -0.7 1.2
Current tobacco smoking 0.9 1.5 1.7 1.3 -1.1 1.3
Average weekly fortified wine intake 0.7 0.8 1.9 1.4 0.7 -0.1
Maternal smoking around birth 0.2 0.3 0.7 -0.8 -0.4 0.2
Fed-up feelings 0.3 0.6 0.9 0.9 -0.3 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.1 -1.0 0.9 -1.4
Relative age voice broke 0.0 0.1 0.1 -0.0 0.4 0.3
Taking other prescription medications 0.5 0.7 1.5 -1.2 -0.6 -0.5
Age when periods started (menarche) 0.2 0.5 1.0 -1.0 -0.6 -0.3
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.2 -0.9 -0.4 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.2 8.6 -2.9 2.0 -0.2
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.4 -0.7 1.5 -1.2
Qualifications: CSEs or equivalent 2.4 3.1 5.9 -0.0 1.9 -2.4
Serious illness, injury or assault to yourself 0.8 1.0 2.4 -0.4 -0.6 1.5
High blood pressure 0.2 0.5 1.3 -1.2 -0.3 0.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.6 1.3 0.7 0.3
Multivitamins +/- minerals 0.5 0.7 1.6 -0.1 0.6 -1.3
Stomach or abdominal pain in last month 1.7 2.1 4.8 0.6 1.0 -2.2
Supplements: Glucosamine 1.1 1.4 4.0 -0.2 0.4 2.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.3 -1.1 0.3 -0.4
Medication: Atenolol 0.3 0.3 0.6 0.2 -0.6 -0.8
Medication: Levothyroxine sodium 1.2 2.1 3.8 0.7 1.4 -1.9
Sitting height 0.1 0.6 1.4 0.4 -0.4 1.2
Chronic bronchitis/emphysema (father) 0.6 0.7 1.6 -1.3 0.2 0.7
High blood pressure (mother) 0.7 1.0 2.3 -0.8 0.2 -1.5
Body mass index (BMI) 0.0 0.1 0.1 0.2 -0.4 -0.3
Impedance of leg (left) 0.6 3.0 6.0 -2.5 -1.7 0.3
Leg predicted mass (left) 0.4 2.2 4.1 2.0 -0.8 1.3
Trunk fat mass 0.3 1.4 4.0 0.1 -2.0 0.6
Waist circumference 0.8 2.9 5.2 -0.3 -1.9 2.3
Number of incorrect matches in round 1.2 2.0 5.1 -2.3 0.5 -0.9
Past tobacco smoking 1.0 1.8 3.8 1.9 -0.7 1.0
Alcohol usually taken with meals 2.0 3.3 5.4 0.4 2.1 -2.3
Nervous feelings 1.4 2.5 5.5 -0.3 1.4 -2.3
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 8.5 -0.6 1.7 -2.9
Hearing difficulty/problems with background noise 0.6 0.9 1.4 -1.2 -1.1 0.2
Hair/balding pattern: Pattern 2 0.4 0.5 0.8 -0.7 0.1 -0.9
Had menopause 0.2 0.3 0.5 -0.5 -0.7 -0.1
Had other major operations 0.8 1.0 2.9 0.1 -0.4 -1.7
Forced vital capacity (FVC) 2.4 9.2 14.2 2.2 -3.0 3.8
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 6.0 -2.5 2.1 -0.1
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 3.4 -1.1 -0.0 -1.8
Qualifications: None of the above 0.2 0.4 0.6 -0.6 -0.7 0.6
Financial difficulties in last 2 years 0.7 1.0 2.4 -0.6 -1.6 -0.4
Mouth/teeth dental problems 0.2 0.4 0.6 -0.0 -0.8 0.7
Heart attack 1.1 1.4 3.3 -0.9 0.2 -1.8
Allergy 0.2 0.4 0.9 -0.9 -0.6 0.0
Pain all over the body in last month 0.4 0.4 1.1 -0.3 -1.1 -0.2
Diabetes (self-reported) 0.1 0.2 0.5 0.7 0.2 -0.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 0.5 -0.2 1.0
Medication: Ramipril 0.1 0.1 0.2 0.5 -0.0 0.4
Medication: Simvastatin 0.2 0.3 0.5 -0.7 -0.2 -0.4
Fluid intelligence score 2.1 4.4 10.2 1.6 -0.7 3.2
Illnesses of siblings 0.5 0.7 1.7 1.3 0.2 -0.7
Neuroticism score 1.2 2.5 4.7 1.0 1.3 -2.2
Weight 0.4 2.0 2.9 0.9 -1.5 1.7
Impedance of arm (right) 0.2 1.0 2.6 -1.6 -0.4 -0.4
Arm fat percentage (right) 0.1 0.5 0.8 -0.7 -0.9 -0.4
Trunk fat-free mass 0.9 4.9 7.8 2.1 -1.6 2.8
Hip circumference 0.1 0.6 0.9 -0.0 -0.9 1.0
Time employed in main current job 1.6 1.9 3.0 -0.7 1.5 -1.7
Alcohol intake versus 10 years previously 1.1 1.7 3.4 -0.2 -1.2 1.8
Father’s age at death 1.2 1.6 3.5 -0.5 1.9 -1.0
Worrier / anxious feelings 0.1 0.2 0.4 0.6 -0.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.2 -0.4 0.1 0.2
Falls in the last year 1.2 1.6 4.1 -0.6 0.5 2.0
Hair/balding pattern: Pattern 3 2.1 3.1 5.4 2.3 1.8 0.8
Number of live births 0.4 0.5 0.9 1.0 0.1 -0.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.4 1.5 -1.3 0.3
Pulse rate 0.3 0.4 1.0 -1.0 -0.5 -0.3
Happiness 1.0 1.2 2.2 -0.9 -0.7 1.5
Noisy workplace 0.9 1.1 1.6 -1.3 1.1 -0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.3 0.7 0.8 1.5
Serious illness, injury or assault of a close relative in last 2 years 2.7 3.0 5.1 1.3 -1.5 2.2
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 1.1 0.5 0.2
Asthma 0.4 0.8 1.3 -1.0 -0.4 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.4 -0.4 -0.7 -0.0
Medication: Cholesterol lowering 1.2 1.9 3.6 -1.2 0.8 -1.9
Depression (self-reported) 0.6 0.8 1.8 0.5 -1.4 0.5
Medication: Lansoprazole 0.4 0.4 0.9 -0.9 0.7 -0.1
Prospective memory result 0.8 0.9 2.2 -0.6 -0.5 -1.5
Lung cancer (father) 0.3 0.3 0.9 0.0 0.3 -1.0
Illnesses of mother 1.0 1.2 1.6 1.2 1.0 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.5 1.0 -1.2 0.5
Pulse wave Arterial Stiffness index 3.5 4.1 11.2 -1.0 -3.3 -0.2
Impedance of arm (left) 0.1 0.5 0.9 -1.0 -0.4 -0.6
Arm fat mass (right) 0.1 0.6 1.6 -0.1 -1.3 0.4
Trunk predicted mass 0.9 4.9 8.0 2.0 -1.6 2.8
Standing height 1.0 9.7 18.7 1.9 -2.6 4.3
Length of working week for main job 1.4 1.5 3.5 -1.1 -1.9 -0.0
Exposure to tobacco smoke at home 0.1 0.2 0.4 0.6 -0.3 -0.0
Breastfed as a baby 0.1 0.2 0.5 0.7 0.0 0.2
Tense / ‘highly strung’ 1.1 1.8 3.5 -0.7 1.2 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.5 -1.2 -0.7 0.3
Hair/balding pattern: Pattern 4 5.2 12.7 21.3 -0.1 -4.1 4.6
Birth weight of first child 0.0 0.1 0.1 0.2 0.4 0.0
Peak expiratory flow (PEF) 0.4 0.9 1.7 1.3 -0.3 -0.9
Pulse wave reflection index 1.9 2.3 6.5 -0.4 -2.5 -0.5
Ever highly irritable/argumentative for 2 days 2.0 2.4 4.7 -1.5 -2.2 -0.5
Loud music exposure frequency 1.1 1.3 3.0 0.8 -1.7 0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.7 1.3 0.2 0.3
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 2.3 -1.5 -0.1 -1.5
Blood clot in the leg (DVT) 0.8 1.0 2.4 0.6 0.4 -1.6
Medication: Paracetamol 0.6 1.0 1.9 0.1 -1.4 1.0
Headache pain in last month 0.7 1.2 2.6 0.2 -1.0 -1.6
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 0.1 0.5 0.5
Glaucoma (self-reported) 0.5 0.6 1.3 0.1 -0.7 1.1
Gout (self-reported) 1.1 1.5 3.5 0.9 1.9 -0.6
Hypothyroidism/myxoedema (self-reported) 2.8 5.4 11.1 -0.9 2.1 -3.3
Medication: Amlodipine 0.8 1.1 1.7 -0.5 1.2 -1.3
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 1.0 -0.3 0.2
Birth weight 1.4 3.0 8.4 -0.5 0.5 2.9
Chronic bronchitis/emphysema (mother) 1.5 1.7 3.3 -1.8 0.7 -1.1
High blood pressure (siblings) 1.0 1.4 3.8 -1.9 0.4 0.4
Forced vital capacity (FVC), Best measure 1.8 6.6 10.6 1.8 -2.4 3.3
Body fat percentage 0.3 1.1 3.0 -0.4 -1.7 -0.2
Leg fat percentage (right) 0.3 1.1 3.0 -0.3 -1.7 0.3
Arm fat-free mass (right) 0.6 3.0 3.4 1.8 -1.5 1.8
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.4 -0.2 -0.8
Comparative body size at age 10 0.1 0.3 0.9 -0.9 -0.3 -0.3
Number of full brothers 1.4 1.8 4.6 0.6 -0.6 2.1
Worry too long after embarrassment 0.7 1.2 1.7 0.7 1.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.7 0.6 -0.7 0.8
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 0.4 -0.7 0.9
Number of children fathered 0.4 0.5 0.8 0.8 0.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 0.4 -0.8 0.0
Age at first live birth 0.2 0.3 0.8 -0.9 -0.1 0.1
Pulse wave peak to peak time 2.7 3.1 7.8 1.0 2.8 0.8
Health satisfaction 0.6 0.8 2.1 -0.4 -1.5 0.2
Shortness of breath walking on level ground 1.7 2.0 3.2 0.2 -1.6 1.8
Qualifications: College or University degree 1.2 3.9 10.0 1.1 -0.6 3.2
Eye problems/disorders: None of the above 0.9 1.0 1.7 1.3 0.3 1.1
Mouth/teeth dental problems: Loose teeth 0.6 0.7 0.9 -0.7 0.9 -0.9
Emphysema/chronic bronchitis 1.4 1.6 4.6 0.5 0.1 2.1
Medication for pain relief, constipation, heartburn 0.0 0.1 0.2 0.4 -0.2 0.1
Neck or shoulder pain in last month 0.7 0.9 1.9 -0.9 -0.3 -1.4
Medication: Blood pressure 0.3 0.5 1.0 0.2 -0.7 1.0
Angina (self-reported) 0.6 0.8 1.7 1.3 -0.8 0.4
Migraine (self-reported) 1.0 1.3 2.8 0.5 -0.9 -1.7
Medication: Ibuprofen 0.3 0.4 0.6 -0.8 -0.1 -0.7
Medication: Allopurinol 0.5 0.7 1.2 0.9 1.1 0.0
Medication: Omeprazole 0.6 0.7 2.2 -0.1 -1.5 0.1
Medication: Seretide 50 evohaler 7.2 8.3 16.5 2.7 -1.1 4.1
Mean time to correctly identify matches 0.7 1.4 1.9 -1.4 -0.9 -1.1
Heart disease (mother) 0.6 0.8 1.4 -1.0 -1.2 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 2.4 -1.3 1.5 -0.9
Whole body fat mass 0.3 1.2 3.3 0.1 -1.8 0.4
Leg fat mass (right) 0.3 1.2 3.3 0.0 -1.8 0.7
Arm predicted mass (right) 0.5 2.6 3.0 1.7 -1.3 1.7
Pulse rate, automated reading 0.1 0.2 0.2 -0.4 -0.4 -0.4
Alcohol intake frequency. 0.6 1.4 2.7 -1.2 0.1 -1.7
Comparative height size at age 10 0.9 5.2 8.1 -0.6 -2.7 2.8
Number of full sisters 1.8 2.1 4.4 -0.2 -2.1 1.4
Suffer from ‘nerves’ 2.1 3.4 6.7 -1.0 1.6 -2.6
Overall health rating 0.0 0.1 0.2 0.1 -0.4 0.1
Chest pain or discomfort 2.1 3.0 4.2 2.1 -0.8 2.0
Had major operations 2.1 2.5 3.0 1.7 -1.4 1.6
Age at last live birth 0.1 0.2 0.2 -0.4 -0.5 -0.4
Family relationship satisfaction 1.0 1.2 1.5 -1.1 -0.9 1.2
Leg pain on walking 1.2 1.4 2.1 -1.5 -0.7 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.2 0.8 -1.5 1.2
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 0.0 -0.2 0.2
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.0 1.4 0.8 0.6
Medication: Aspirin 0.7 1.0 2.5 -0.7 1.6 0.0
Supplements: Vitamin C 2.7 3.2 3.9 -1.7 2.0 -1.7
Knee pain experienced in last month 0.3 0.5 1.1 -0.6 0.3 -1.0
Hypertension (Self-reported) 0.1 0.2 0.7 -0.8 -0.1 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.8 -0.6 -0.6 1.3
Illnesses of father: Heart disease 1.4 1.9 5.7 -0.1 2.4 -0.0
Illnesses of siblings: Diabetes 0.0 0.1 0.1 -0.1 -0.3 0.2
Smoking status: Previous 2.5 3.7 4.8 -2.2 1.5 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.4 0.6 -0.5 0.4
Whole body fat-free mass 0.6 3.2 4.2 1.9 -1.3 2.0
Leg fat-free mass (right) 0.2 1.3 2.7 1.6 -0.5 1.0
Arm fat percentage (left) 0.1 0.4 1.1 -0.2 -1.0 -0.4
Average weekly red wine intake 1.0 1.4 3.8 2.0 0.3 0.6
Handedness (chirality/laterality): Left-handed 0.6 0.7 0.9 -0.8 -0.9 0.7
Mood swings 1.5 2.7 5.4 -0.2 1.7 -2.3
Loneliness, isolation 0.6 0.8 2.2 -0.5 0.2 -1.5
Long-standing illness, disability or infirmity 0.2 0.2 0.6 -0.8 -0.3 -0.0
Ever had bowel cancer screening 0.1 0.1 0.2 0.0 0.4 0.0
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.6 0.1 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.7 0.8 -0.3 -0.0
Friendships satisfaction 0.8 1.0 2.3 -1.5 -0.1 0.8
Qualifications: nursing, teaching 1.6 2.5 3.8 -0.8 1.8 -1.9
Commuting to job workplace: Walk 0.9 1.0 3.0 0.1 1.7 0.1
Eye problems/disorders: Cataract 1.1 1.3 2.0 -1.4 0.0 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.4 -0.6 0.2 0.2
Medication for cholesterol 0.6 0.9 2.2 1.5 0.7 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 -0.3 -0.6 0.4
Back pain experienced in last month 0.3 0.4 0.7 0.3 -0.7 -0.8
Mineral and other dietary supplements 0.5 0.7 1.6 -0.4 -0.6 -1.3
Breast cancer (self-reported) 1.2 1.4 2.1 1.4 1.2 -0.8
Asthma (self-reported) 0.4 0.8 2.0 -0.6 -0.4 1.4
Osteoporosis (self-reported) 2.4 3.0 6.5 2.5 0.6 1.5
Osteoarthritis (self-reported) 1.7 2.2 4.2 -2.1 0.5 -1.5
Medication: Aspirin 0.9 1.2 2.9 -0.7 1.7 -0.5
Medication: Gliclazide 0.9 1.0 2.1 0.8 0.5 -1.5
Illnesses of father: None of the above (group 1) 1.9 2.4 6.1 0.7 -2.5 0.7
Smoking status: Current 0.6 1.0 1.5 1.0 -0.8 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.7 -0.3 -0.5 -0.9
Whole body water mass 0.5 2.9 3.8 1.9 -1.2 1.9
Leg predicted mass (right) 0.2 1.3 2.5 1.6 -0.5 1.0
Arm fat mass (left) 0.2 0.7 1.9 -0.1 -1.4 0.4
Number of self-reported non-cancer illnesses 0.3 0.4 0.8 -0.9 0.6 0.3
Average weekly champagne plus white wine intake 0.5 0.7 1.7 -0.6 0.3 -1.3
Miserableness 0.6 1.0 1.6 1.1 1.3 -0.4
Guilty feelings 1.2 1.9 5.1 2.2 -0.7 -0.3
Wears glasses or contact lenses 0.4 0.4 1.0 -1.0 -0.4 -0.2
Ever taken oral contraceptive pill 0.4 0.4 1.1 0.4 1.1 -0.1
Hearing aid user 1.1 1.2 2.3 1.5 0.5 1.0
Mother’s age at death 0.2 0.3 0.6 -0.5 -0.0 -0.8
Financial situation satisfaction 0.4 0.5 0.7 -0.5 -0.9 0.8
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.0 -0.5 1.0 -0.4
Commuting to job workplace: Public transport 1.2 1.4 2.4 -1.1 -0.8 1.5
Eye problems/disorders: Glaucoma 0.4 0.4 0.7 -0.4 -0.8 0.6
Medication: Blood pressure 1.0 1.8 4.2 -2.1 0.4 -1.1
Pain type(s) experienced in last month: Hip pain 1.9 2.4 4.2 -0.8 1.5 -2.1
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.1 1.1 1.4 0.1
High cholesterol (Self-reported) 0.9 1.7 3.2 -1.8 -0.1 -1.3
Medication: Bendroflumethiazide 1.3 2.0 4.2 -2.0 -0.9 0.9
Medication: Paracetamol 0.1 0.1 0.4 0.2 -0.6 0.1
Medication: Lisinopril 0.8 1.1 2.7 -0.1 -0.7 1.6
Medication: Atorvastatin 0.7 0.8 2.2 -0.5 -1.5 0.3
Illnesses of father: High blood pressure 2.2 2.8 6.4 0.5 1.3 -2.5
Alcohol drinker status: Never 1.4 1.7 4.3 2.1 0.2 -0.9
Ever smoked 1.2 2.2 3.5 -1.9 0.3 -1.7
Basal metabolic rate 0.6 3.2 4.4 1.7 -1.4 2.1
Leg fat percentage (left) 0.3 1.2 2.5 -1.0 -1.6 -0.2
Arm fat-free mass (left) 0.5 2.7 4.5 1.0 -1.6 2.1
Number of operations (self-reported) 0.5 0.8 1.1 -1.1 -0.9 -0.6
Average weekly beer plus cider intake 0.4 0.6 1.1 -0.9 0.0 1.0
Irritability 2.2 3.7 6.8 -0.9 1.9 -2.6
Risk taking 0.3 0.5 0.7 0.6 -0.7 0.8
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.0 -1.4 1.0 -0.5
Fractured/broken bones in last 5 years 0.3 0.4 0.6 0.7 -0.8 0.2
Age started oral contraceptive pill 0.2 0.2 0.4 0.4 -0.6 -0.3
Diastolic blood pressure, automated reading 0.1 0.2 0.6 0.3 0.1 -0.7
Ever depressed for a whole week 0.6 0.7 1.2 -1.1 -0.1 -1.0
Unable to work because of sickness or disability 0.6 0.8 2.2 0.2 -1.5 0.2
Commuting to job workplace: Cycle 1.6 1.9 2.5 -1.2 1.6 -1.4
Myopia 3.9 5.6 12.1 -0.8 2.0 -3.5
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.7 0.9 0.6 0.0
Cholesterol lowering medication 0.6 0.9 2.0 -0.6 -1.4 0.5
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 2.0 -0.3 -1.4 0.2
Pain experienced in last month 0.5 0.8 2.1 0.3 0.5 1.5
Supplements: Calcium 0.2 0.2 0.5 0.7 -0.4 -0.0
Basal cell carcinoma (self-reported) 0.9 1.1 3.2 0.0 -0.3 1.8
Heart attack/myocardial infarction (self-reported) 1.2 1.6 3.6 -1.0 0.3 -1.9
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 3.2 0.8 0.0 -1.8
Heart disease (siblings) 0.1 0.1 0.3 0.2 0.6 -0.2
Alcohol drinker status: Previous 2.5 2.8 7.5 -2.7 0.7 -0.7
Pack years of smoking 0.9 1.4 3.1 0.3 -1.0 1.8
Impedance of whole body 0.2 1.3 2.7 -1.6 -1.0 -0.1
Leg fat mass (left) 0.3 1.1 3.1 -0.4 -1.8 0.3
Arm predicted mass (left) 0.5 2.5 4.0 1.1 -1.6 2.0