Hub : Genes

PARD6A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.465	0.1253	0.0016	0.000	NA	0.019	NA	0.024	0.32000	NA	0.110	NA	0.08800
2	GTEx	Breast Mammary Tissue (Male)	0.151	0.0966	0.0480	0.025	NA	-0.012	NA	0.031	0.08600	NA	0.750	NA	0.06600
3	GTEx	Pancreas	0.084	0.0470	0.0028	0.092	NA	0.041	NA	0.078	0.00011	NA	0.008	NA	0.00033

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	3.6	-0.1	0.0	-1.9
Bipolar Disorder or Schizophrenia	2.9	7.0	13.7	-2.4	1.2	-3.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.5	0.6	0.8	-1.2
Depression (Nagel 2018)	0.9	1.3	2.7	-1.0	0.3	-1.7
Intelligence (Savage-Jansen 2018)	1.1	3.2	8.6	1.0	-0.2	2.9
Neuroticism (Nagel 2018)	0.8	1.9	5.2	0.5	0.5	-2.3
Schizophrenia (2018)	3.5	7.3	10.3	-3.0	1.6	-3.2
Schizophrenia vs Biploar Disorder	0.7	0.9	1.0	-0.8	1.0	-1.0
Worry (Nagel 2018)	1.1	2.3	6.7	-0.1	0.6	-2.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-1.0	-0.8	0.2
Alzheimer’s Disease (in father)	0.9	1.0	2.9	0.2	-0.2	-1.7
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.4	-0.8	-0.7
Crohns Disease (2017)	1.3	2.9	4.8	1.4	-1.4	2.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	0.3	-1.0	0.7
Ulcerative Colitis (UC)	0.5	0.9	1.3	-1.2	0.3	-1.2
Major Depression (MDD)	0.3	0.4	0.9	-0.4	-0.9	-0.4
Reaction Time	0.4	0.7	1.0	-1.0	-0.8	-0.7
Verbal and Numeric Reasoning (VNR)	1.4	3.3	6.8	1.7	-0.5	2.6
Breast Cancer	0.4	0.9	2.6	-0.4	0.1	1.6
Ovarian Cancer	4.0	5.3	12.7	1.7	-0.4	3.6
Prostate Cancer	1.6	2.3	5.7	0.6	-0.9	2.4
Age at First Birth	0.2	0.3	0.6	-0.6	-0.0	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.1	-0.1	-0.0
Coronary Artery Disease (CAD)	1.7	2.0	3.5	1.1	-1.1	1.9
Crohns Disease (2012)	0.9	1.5	3.0	0.8	-0.9	1.7
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.5	0.1
Fasting Glucose	3.6	4.3	6.9	1.8	-1.7	2.6
HbA1C	0.2	0.2	0.5	0.1	-0.7	0.3
HDL Cholesterol	24.5	40.8	74.1	-7.0	-0.1	-8.6
LDL Cholesterol	0.2	0.4	0.9	-0.9	-0.5	-0.2
Lupus	2.7	4.1	5.5	-2.4	1.5	-2.1
Neuroticism (2016)	0.6	0.9	2.5	0.2	0.1	-1.6
Primary Biliary Cirrhosis	1.2	1.6	3.4	-1.2	0.0	-1.9
Rheumatoid Arthritis	0.7	0.9	2.8	1.7	-0.1	0.1
Schizophrenia (2014)	2.6	5.7	9.0	-2.6	1.1	-3.0
Triglycerides	0.3	0.5	1.3	0.4	-0.1	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	1.1	-0.5	0.7
Ulcerative Colitis	0.2	0.3	0.4	-0.7	-0.5	-0.5
Blood Eosinophil Count	0.1	0.8	1.4	1.2	-0.6	-0.9
Blood Platelet Count	0.2	2.5	4.4	0.7	-2.1	1.6
Blood Red Count	6.0	57.9	125.4	-5.7	3.9	-11.2
Blood White Count	1.1	8.3	17.1	1.1	-4.1	2.5
Heel T-Score	2.7	21.2	36.6	-6.0	4.2	-3.1
BMI	0.2	1.3	2.1	1.4	-1.0	-0.8
Height	0.5	10.0	18.3	1.8	-2.9	4.3
Waist Hip Ratio (WHR)	1.2	5.5	13.5	0.3	-1.7	3.7
Systolic Blood Pressure	0.1	0.7	1.3	1.1	0.8	-0.4
Smoking Status	0.2	0.5	1.0	0.2	0.7	-1.0
Allergy or Eczema	0.7	1.7	3.0	1.5	0.3	1.7
Cardiovascular Disease	0.1	0.5	1.2	-0.4	-1.1	-0.1
Hypothyroidism (self reported)	3.2	7.4	15.6	-1.2	2.3	-4.0
Respiratory disease	0.5	1.1	2.6	0.2	-0.8	1.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	0.3	-0.6	0.2
Lung FEV1/FVC ratio	7.5	38.2	92.4	-2.1	4.2	-9.6
Lung FVC	1.1	5.5	12.1	0.8	-1.9	3.5
Neuroticism	1.0	2.5	6.3	0.4	1.0	-2.5
Chronotype (morning person)	3.0	7.0	8.4	2.2	-2.8	2.9
Hair Pigment	0.4	11.5	23.8	-2.8	1.7	-4.9
Tanning	0.0	0.4	0.6	-0.8	-0.4	0.7
Hand grip strength (left)	0.3	0.9	2.5	1.6	0.1	0.3
Number of treatments/medications taken	0.7	1.3	3.3	-1.8	-0.3	-0.8
Average weekly spirits intake	1.5	1.9	4.1	1.2	-0.2	2.0
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.4	-0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.9	-0.8	0.6	-1.7
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.4	-0.4	0.6
Relative age of first facial hair	0.1	0.1	0.3	-0.4	0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	-0.2	-0.8	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	0.9	-0.8	-0.7	1.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	1.1	-1.1	0.0
Systolic blood pressure, automated reading	0.3	0.8	2.3	1.5	0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.2	-1.5	0.4	0.3
Angina	0.6	0.8	1.8	1.3	-0.7	0.3
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.6	-0.2	-0.1
Vitamin and mineral supplements	1.1	1.5	1.7	1.0	-1.3	1.3
Supplements: Zinc	1.5	1.6	4.5	0.2	0.4	-2.1
Medication: Co-codamol	0.4	0.5	0.8	-0.7	0.2	-0.9
Medication: Metformin	0.1	0.2	0.5	0.4	0.7	0.0
Diabetes (father)	1.0	1.3	3.0	-0.0	1.7	-0.9
Diabetes (mother)	0.2	0.3	0.5	-0.1	-0.5	-0.7
Severe depression (siblings)	0.6	0.7	2.1	1.4	0.1	-0.2
Pack years adult smoking proportion	1.0	1.5	2.8	0.4	-1.2	1.7
Impedance of leg (right)	0.5	2.3	3.7	-1.4	-1.9	1.1
Leg fat-free mass (left)	0.4	2.2	4.2	2.1	-0.8	1.3
Trunk fat percentage	0.3	1.1	2.9	-0.5	-1.7	-0.3
Hand grip strength (right)	0.4	1.0	2.1	1.4	1.0	-0.3
Townsend deprivation index at recruitment	0.5	0.7	1.5	-0.3	-0.7	1.2
Current tobacco smoking	0.9	1.5	1.7	1.3	-1.1	1.3
Average weekly fortified wine intake	0.7	0.8	1.9	1.4	0.7	-0.1
Maternal smoking around birth	0.2	0.3	0.7	-0.8	-0.4	0.2
Fed-up feelings	0.3	0.6	0.9	0.9	-0.3	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.1	-1.0	0.9	-1.4
Relative age voice broke	0.0	0.1	0.1	-0.0	0.4	0.3
Taking other prescription medications	0.5	0.7	1.5	-1.2	-0.6	-0.5
Age when periods started (menarche)	0.2	0.5	1.0	-1.0	-0.6	-0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.2	-0.9	-0.4	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.2	8.6	-2.9	2.0	-0.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	-0.7	1.5	-1.2
Qualifications: CSEs or equivalent	2.4	3.1	5.9	-0.0	1.9	-2.4
Serious illness, injury or assault to yourself	0.8	1.0	2.4	-0.4	-0.6	1.5
High blood pressure	0.2	0.5	1.3	-1.2	-0.3	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	1.3	0.7	0.3
Multivitamins +/- minerals	0.5	0.7	1.6	-0.1	0.6	-1.3
Stomach or abdominal pain in last month	1.7	2.1	4.8	0.6	1.0	-2.2
Supplements: Glucosamine	1.1	1.4	4.0	-0.2	0.4	2.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	-1.1	0.3	-0.4
Medication: Atenolol	0.3	0.3	0.6	0.2	-0.6	-0.8
Medication: Levothyroxine sodium	1.2	2.1	3.8	0.7	1.4	-1.9
Sitting height	0.1	0.6	1.4	0.4	-0.4	1.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-1.3	0.2	0.7
High blood pressure (mother)	0.7	1.0	2.3	-0.8	0.2	-1.5
Body mass index (BMI)	0.0	0.1	0.1	0.2	-0.4	-0.3
Impedance of leg (left)	0.6	3.0	6.0	-2.5	-1.7	0.3
Leg predicted mass (left)	0.4	2.2	4.1	2.0	-0.8	1.3
Trunk fat mass	0.3	1.4	4.0	0.1	-2.0	0.6
Waist circumference	0.8	2.9	5.2	-0.3	-1.9	2.3
Number of incorrect matches in round	1.2	2.0	5.1	-2.3	0.5	-0.9
Past tobacco smoking	1.0	1.8	3.8	1.9	-0.7	1.0
Alcohol usually taken with meals	2.0	3.3	5.4	0.4	2.1	-2.3
Nervous feelings	1.4	2.5	5.5	-0.3	1.4	-2.3
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	8.5	-0.6	1.7	-2.9
Hearing difficulty/problems with background noise	0.6	0.9	1.4	-1.2	-1.1	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.8	-0.7	0.1	-0.9
Had menopause	0.2	0.3	0.5	-0.5	-0.7	-0.1
Had other major operations	0.8	1.0	2.9	0.1	-0.4	-1.7
Forced vital capacity (FVC)	2.4	9.2	14.2	2.2	-3.0	3.8
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	6.0	-2.5	2.1	-0.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.4	-1.1	-0.0	-1.8
Qualifications: None of the above	0.2	0.4	0.6	-0.6	-0.7	0.6
Financial difficulties in last 2 years	0.7	1.0	2.4	-0.6	-1.6	-0.4
Mouth/teeth dental problems	0.2	0.4	0.6	-0.0	-0.8	0.7
Heart attack	1.1	1.4	3.3	-0.9	0.2	-1.8
Allergy	0.2	0.4	0.9	-0.9	-0.6	0.0
Pain all over the body in last month	0.4	0.4	1.1	-0.3	-1.1	-0.2
Diabetes (self-reported)	0.1	0.2	0.5	0.7	0.2	-0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	0.5	-0.2	1.0
Medication: Ramipril	0.1	0.1	0.2	0.5	-0.0	0.4
Medication: Simvastatin	0.2	0.3	0.5	-0.7	-0.2	-0.4
Fluid intelligence score	2.1	4.4	10.2	1.6	-0.7	3.2
Illnesses of siblings	0.5	0.7	1.7	1.3	0.2	-0.7
Neuroticism score	1.2	2.5	4.7	1.0	1.3	-2.2
Weight	0.4	2.0	2.9	0.9	-1.5	1.7
Impedance of arm (right)	0.2	1.0	2.6	-1.6	-0.4	-0.4
Arm fat percentage (right)	0.1	0.5	0.8	-0.7	-0.9	-0.4
Trunk fat-free mass	0.9	4.9	7.8	2.1	-1.6	2.8
Hip circumference	0.1	0.6	0.9	-0.0	-0.9	1.0
Time employed in main current job	1.6	1.9	3.0	-0.7	1.5	-1.7
Alcohol intake versus 10 years previously	1.1	1.7	3.4	-0.2	-1.2	1.8
Father’s age at death	1.2	1.6	3.5	-0.5	1.9	-1.0
Worrier / anxious feelings	0.1	0.2	0.4	0.6	-0.2	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	-0.4	0.1	0.2
Falls in the last year	1.2	1.6	4.1	-0.6	0.5	2.0
Hair/balding pattern: Pattern 3	2.1	3.1	5.4	2.3	1.8	0.8
Number of live births	0.4	0.5	0.9	1.0	0.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.4	1.5	-1.3	0.3
Pulse rate	0.3	0.4	1.0	-1.0	-0.5	-0.3
Happiness	1.0	1.2	2.2	-0.9	-0.7	1.5
Noisy workplace	0.9	1.1	1.6	-1.3	1.1	-0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.3	0.7	0.8	1.5
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.0	5.1	1.3	-1.5	2.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	1.1	0.5	0.2
Asthma	0.4	0.8	1.3	-1.0	-0.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.4	-0.7	-0.0
Medication: Cholesterol lowering	1.2	1.9	3.6	-1.2	0.8	-1.9
Depression (self-reported)	0.6	0.8	1.8	0.5	-1.4	0.5
Medication: Lansoprazole	0.4	0.4	0.9	-0.9	0.7	-0.1
Prospective memory result	0.8	0.9	2.2	-0.6	-0.5	-1.5
Lung cancer (father)	0.3	0.3	0.9	0.0	0.3	-1.0
Illnesses of mother	1.0	1.2	1.6	1.2	1.0	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.5	1.0	-1.2	0.5
Pulse wave Arterial Stiffness index	3.5	4.1	11.2	-1.0	-3.3	-0.2
Impedance of arm (left)	0.1	0.5	0.9	-1.0	-0.4	-0.6
Arm fat mass (right)	0.1	0.6	1.6	-0.1	-1.3	0.4
Trunk predicted mass	0.9	4.9	8.0	2.0	-1.6	2.8
Standing height	1.0	9.7	18.7	1.9	-2.6	4.3
Length of working week for main job	1.4	1.5	3.5	-1.1	-1.9	-0.0
Exposure to tobacco smoke at home	0.1	0.2	0.4	0.6	-0.3	-0.0
Breastfed as a baby	0.1	0.2	0.5	0.7	0.0	0.2
Tense / ‘highly strung’	1.1	1.8	3.5	-0.7	1.2	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.5	-1.2	-0.7	0.3
Hair/balding pattern: Pattern 4	5.2	12.7	21.3	-0.1	-4.1	4.6
Birth weight of first child	0.0	0.1	0.1	0.2	0.4	0.0
Peak expiratory flow (PEF)	0.4	0.9	1.7	1.3	-0.3	-0.9
Pulse wave reflection index	1.9	2.3	6.5	-0.4	-2.5	-0.5
Ever highly irritable/argumentative for 2 days	2.0	2.4	4.7	-1.5	-2.2	-0.5
Loud music exposure frequency	1.1	1.3	3.0	0.8	-1.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	1.3	0.2	0.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.3	-1.5	-0.1	-1.5
Blood clot in the leg (DVT)	0.8	1.0	2.4	0.6	0.4	-1.6
Medication: Paracetamol	0.6	1.0	1.9	0.1	-1.4	1.0
Headache pain in last month	0.7	1.2	2.6	0.2	-1.0	-1.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.1	0.5	0.5
Glaucoma (self-reported)	0.5	0.6	1.3	0.1	-0.7	1.1
Gout (self-reported)	1.1	1.5	3.5	0.9	1.9	-0.6
Hypothyroidism/myxoedema (self-reported)	2.8	5.4	11.1	-0.9	2.1	-3.3
Medication: Amlodipine	0.8	1.1	1.7	-0.5	1.2	-1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	1.0	-0.3	0.2
Birth weight	1.4	3.0	8.4	-0.5	0.5	2.9
Chronic bronchitis/emphysema (mother)	1.5	1.7	3.3	-1.8	0.7	-1.1
High blood pressure (siblings)	1.0	1.4	3.8	-1.9	0.4	0.4
Forced vital capacity (FVC), Best measure	1.8	6.6	10.6	1.8	-2.4	3.3
Body fat percentage	0.3	1.1	3.0	-0.4	-1.7	-0.2
Leg fat percentage (right)	0.3	1.1	3.0	-0.3	-1.7	0.3
Arm fat-free mass (right)	0.6	3.0	3.4	1.8	-1.5	1.8
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.4	-0.2	-0.8
Comparative body size at age 10	0.1	0.3	0.9	-0.9	-0.3	-0.3
Number of full brothers	1.4	1.8	4.6	0.6	-0.6	2.1
Worry too long after embarrassment	0.7	1.2	1.7	0.7	1.2	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.6	-0.7	0.8
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	0.4	-0.7	0.9
Number of children fathered	0.4	0.5	0.8	0.8	0.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.4	-0.8	0.0
Age at first live birth	0.2	0.3	0.8	-0.9	-0.1	0.1
Pulse wave peak to peak time	2.7	3.1	7.8	1.0	2.8	0.8
Health satisfaction	0.6	0.8	2.1	-0.4	-1.5	0.2
Shortness of breath walking on level ground	1.7	2.0	3.2	0.2	-1.6	1.8
Qualifications: College or University degree	1.2	3.9	10.0	1.1	-0.6	3.2
Eye problems/disorders: None of the above	0.9	1.0	1.7	1.3	0.3	1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.9	-0.7	0.9	-0.9
Emphysema/chronic bronchitis	1.4	1.6	4.6	0.5	0.1	2.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	0.4	-0.2	0.1
Neck or shoulder pain in last month	0.7	0.9	1.9	-0.9	-0.3	-1.4
Medication: Blood pressure	0.3	0.5	1.0	0.2	-0.7	1.0
Angina (self-reported)	0.6	0.8	1.7	1.3	-0.8	0.4
Migraine (self-reported)	1.0	1.3	2.8	0.5	-0.9	-1.7
Medication: Ibuprofen	0.3	0.4	0.6	-0.8	-0.1	-0.7
Medication: Allopurinol	0.5	0.7	1.2	0.9	1.1	0.0
Medication: Omeprazole	0.6	0.7	2.2	-0.1	-1.5	0.1
Medication: Seretide 50 evohaler	7.2	8.3	16.5	2.7	-1.1	4.1
Mean time to correctly identify matches	0.7	1.4	1.9	-1.4	-0.9	-1.1
Heart disease (mother)	0.6	0.8	1.4	-1.0	-1.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.4	-1.3	1.5	-0.9
Whole body fat mass	0.3	1.2	3.3	0.1	-1.8	0.4
Leg fat mass (right)	0.3	1.2	3.3	0.0	-1.8	0.7
Arm predicted mass (right)	0.5	2.6	3.0	1.7	-1.3	1.7
Pulse rate, automated reading	0.1	0.2	0.2	-0.4	-0.4	-0.4
Alcohol intake frequency.	0.6	1.4	2.7	-1.2	0.1	-1.7
Comparative height size at age 10	0.9	5.2	8.1	-0.6	-2.7	2.8
Number of full sisters	1.8	2.1	4.4	-0.2	-2.1	1.4
Suffer from ‘nerves’	2.1	3.4	6.7	-1.0	1.6	-2.6
Overall health rating	0.0	0.1	0.2	0.1	-0.4	0.1
Chest pain or discomfort	2.1	3.0	4.2	2.1	-0.8	2.0
Had major operations	2.1	2.5	3.0	1.7	-1.4	1.6
Age at last live birth	0.1	0.2	0.2	-0.4	-0.5	-0.4
Family relationship satisfaction	1.0	1.2	1.5	-1.1	-0.9	1.2
Leg pain on walking	1.2	1.4	2.1	-1.5	-0.7	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.2	0.8	-1.5	1.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.0	-0.2	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.0	1.4	0.8	0.6
Medication: Aspirin	0.7	1.0	2.5	-0.7	1.6	0.0
Supplements: Vitamin C	2.7	3.2	3.9	-1.7	2.0	-1.7
Knee pain experienced in last month	0.3	0.5	1.1	-0.6	0.3	-1.0
Hypertension (Self-reported)	0.1	0.2	0.7	-0.8	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.8	-0.6	-0.6	1.3
Illnesses of father: Heart disease	1.4	1.9	5.7	-0.1	2.4	-0.0
Illnesses of siblings: Diabetes	0.0	0.1	0.1	-0.1	-0.3	0.2
Smoking status: Previous	2.5	3.7	4.8	-2.2	1.5	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	0.6	-0.5	0.4
Whole body fat-free mass	0.6	3.2	4.2	1.9	-1.3	2.0
Leg fat-free mass (right)	0.2	1.3	2.7	1.6	-0.5	1.0
Arm fat percentage (left)	0.1	0.4	1.1	-0.2	-1.0	-0.4
Average weekly red wine intake	1.0	1.4	3.8	2.0	0.3	0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	0.9	-0.8	-0.9	0.7
Mood swings	1.5	2.7	5.4	-0.2	1.7	-2.3
Loneliness, isolation	0.6	0.8	2.2	-0.5	0.2	-1.5
Long-standing illness, disability or infirmity	0.2	0.2	0.6	-0.8	-0.3	-0.0
Ever had bowel cancer screening	0.1	0.1	0.2	0.0	0.4	0.0
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.6	0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.7	0.8	-0.3	-0.0
Friendships satisfaction	0.8	1.0	2.3	-1.5	-0.1	0.8
Qualifications: nursing, teaching	1.6	2.5	3.8	-0.8	1.8	-1.9
Commuting to job workplace: Walk	0.9	1.0	3.0	0.1	1.7	0.1
Eye problems/disorders: Cataract	1.1	1.3	2.0	-1.4	0.0	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.6	0.2	0.2
Medication for cholesterol	0.6	0.9	2.2	1.5	0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.3	-0.6	0.4
Back pain experienced in last month	0.3	0.4	0.7	0.3	-0.7	-0.8
Mineral and other dietary supplements	0.5	0.7	1.6	-0.4	-0.6	-1.3
Breast cancer (self-reported)	1.2	1.4	2.1	1.4	1.2	-0.8
Asthma (self-reported)	0.4	0.8	2.0	-0.6	-0.4	1.4
Osteoporosis (self-reported)	2.4	3.0	6.5	2.5	0.6	1.5
Osteoarthritis (self-reported)	1.7	2.2	4.2	-2.1	0.5	-1.5
Medication: Aspirin	0.9	1.2	2.9	-0.7	1.7	-0.5
Medication: Gliclazide	0.9	1.0	2.1	0.8	0.5	-1.5
Illnesses of father: None of the above (group 1)	1.9	2.4	6.1	0.7	-2.5	0.7
Smoking status: Current	0.6	1.0	1.5	1.0	-0.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.3	-0.5	-0.9
Whole body water mass	0.5	2.9	3.8	1.9	-1.2	1.9
Leg predicted mass (right)	0.2	1.3	2.5	1.6	-0.5	1.0
Arm fat mass (left)	0.2	0.7	1.9	-0.1	-1.4	0.4
Number of self-reported non-cancer illnesses	0.3	0.4	0.8	-0.9	0.6	0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-0.6	0.3	-1.3
Miserableness	0.6	1.0	1.6	1.1	1.3	-0.4
Guilty feelings	1.2	1.9	5.1	2.2	-0.7	-0.3
Wears glasses or contact lenses	0.4	0.4	1.0	-1.0	-0.4	-0.2
Ever taken oral contraceptive pill	0.4	0.4	1.1	0.4	1.1	-0.1
Hearing aid user	1.1	1.2	2.3	1.5	0.5	1.0
Mother’s age at death	0.2	0.3	0.6	-0.5	-0.0	-0.8
Financial situation satisfaction	0.4	0.5	0.7	-0.5	-0.9	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-0.5	1.0	-0.4
Commuting to job workplace: Public transport	1.2	1.4	2.4	-1.1	-0.8	1.5
Eye problems/disorders: Glaucoma	0.4	0.4	0.7	-0.4	-0.8	0.6
Medication: Blood pressure	1.0	1.8	4.2	-2.1	0.4	-1.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.2	-0.8	1.5	-2.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.1	1.1	1.4	0.1
High cholesterol (Self-reported)	0.9	1.7	3.2	-1.8	-0.1	-1.3
Medication: Bendroflumethiazide	1.3	2.0	4.2	-2.0	-0.9	0.9
Medication: Paracetamol	0.1	0.1	0.4	0.2	-0.6	0.1
Medication: Lisinopril	0.8	1.1	2.7	-0.1	-0.7	1.6
Medication: Atorvastatin	0.7	0.8	2.2	-0.5	-1.5	0.3
Illnesses of father: High blood pressure	2.2	2.8	6.4	0.5	1.3	-2.5
Alcohol drinker status: Never	1.4	1.7	4.3	2.1	0.2	-0.9
Ever smoked	1.2	2.2	3.5	-1.9	0.3	-1.7
Basal metabolic rate	0.6	3.2	4.4	1.7	-1.4	2.1
Leg fat percentage (left)	0.3	1.2	2.5	-1.0	-1.6	-0.2
Arm fat-free mass (left)	0.5	2.7	4.5	1.0	-1.6	2.1
Number of operations (self-reported)	0.5	0.8	1.1	-1.1	-0.9	-0.6
Average weekly beer plus cider intake	0.4	0.6	1.1	-0.9	0.0	1.0
Irritability	2.2	3.7	6.8	-0.9	1.9	-2.6
Risk taking	0.3	0.5	0.7	0.6	-0.7	0.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.0	-1.4	1.0	-0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.6	0.7	-0.8	0.2
Age started oral contraceptive pill	0.2	0.2	0.4	0.4	-0.6	-0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.6	0.3	0.1	-0.7
Ever depressed for a whole week	0.6	0.7	1.2	-1.1	-0.1	-1.0
Unable to work because of sickness or disability	0.6	0.8	2.2	0.2	-1.5	0.2
Commuting to job workplace: Cycle	1.6	1.9	2.5	-1.2	1.6	-1.4
Myopia	3.9	5.6	12.1	-0.8	2.0	-3.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.7	0.9	0.6	0.0
Cholesterol lowering medication	0.6	0.9	2.0	-0.6	-1.4	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.0	-0.3	-1.4	0.2
Pain experienced in last month	0.5	0.8	2.1	0.3	0.5	1.5
Supplements: Calcium	0.2	0.2	0.5	0.7	-0.4	-0.0
Basal cell carcinoma (self-reported)	0.9	1.1	3.2	0.0	-0.3	1.8
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.6	-1.0	0.3	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.2	0.8	0.0	-1.8
Heart disease (siblings)	0.1	0.1	0.3	0.2	0.6	-0.2
Alcohol drinker status: Previous	2.5	2.8	7.5	-2.7	0.7	-0.7
Pack years of smoking	0.9	1.4	3.1	0.3	-1.0	1.8
Impedance of whole body	0.2	1.3	2.7	-1.6	-1.0	-0.1
Leg fat mass (left)	0.3	1.1	3.1	-0.4	-1.8	0.3
Arm predicted mass (left)	0.5	2.5	4.0	1.1	-1.6	2.0