[Hub]/) : Traits : Systolic Blood Pressure : ← →

chr11:45,258,966-48,783,497

Best TWAS P=3.8e-44 · Best GWAS P=6.33e-37 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AGBL2	0.03	0.02	enet	7	0.03	7.9e-05	-10.53	-10.8	5.9e-27	-0.28	0.89	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARHGAP1	0.16	0.04	enet	18	0.04	2.3e-05	3.59	7.1	1.5e-12	0.25	0.67	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-4.81	-6.1	1.2e-09	-0.70	1.00	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	-7.41	-8.0	1.0e-15	-0.31	0.98	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	-0.24	-6.5	6.5e-11	-0.71	0.08	0.47	FALSE
6	CommonMind	Brain Pre-frontal Cortex	PSMC3	0.04	0.00	enet	22	0.01	3.8e-02	4.11	-5.5	3.5e-08	-0.51	0.07	0.56	FALSE
7	CommonMind	Brain Pre-frontal Cortex	PTPRJ	0.06	0.04	lasso	4	0.05	7.6e-07	-10.70	-11.9	7.1e-33	-0.31	1.00	0.00	FALSE
8	GTEx	Adipose Subcutaneous	PTPRJ	0.05	0.05	lasso	2	0.04	3.9e-04	-6.65	-7.4	1.1e-13	-0.15	0.32	0.04	FALSE
9	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-4.77	6.0	2.3e-09	0.71	1.00	0.00	FALSE
10	GTEx	Adipose Subcutaneous	ARHGAP1	0.08	0.03	lasso	6	0.05	3.4e-05	-7.02	6.0	2.1e-09	0.25	0.78	0.05	FALSE
11	GTEx	Adipose Visceral Omentum	ACP2	0.08	0.05	lasso	5	0.05	1.4e-03	-8.61	8.3	7.3e-17	0.17	0.41	0.04	FALSE
12	GTEx	Artery Aorta	CKAP5	0.09	0.12	lasso	1	0.07	1.2e-04	-6.00	-6.0	2.0e-09	-0.20	0.94	0.00	FALSE
13	GTEx	Artery Tibial	LRP4	0.06	0.00	lasso	5	0.00	6.4e-01	8.71	7.4	1.1e-13	0.43	0.06	0.06	FALSE
14	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-3.71	8.6	1.2e-17	0.30	0.25	0.32	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	11.07	-11.1	1.7e-28	-0.50	0.39	0.16	FALSE
16	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-7.69	-5.6	1.7e-08	-0.48	0.42	0.04	FALSE
17	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	12.60	12.3	5.9e-35	0.92	0.04	0.24	FALSE
18	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	-5.37	-5.4	5.8e-08	0.05	0.15	0.08	FALSE
19	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-6.73	6.6	5.1e-11	0.58	0.30	0.08	FALSE
20	GTEx	Breast Mammary Tissue	CKAP5	0.09	0.05	enet	16	0.03	1.3e-02	-5.99	-5.4	8.5e-08	-0.12	0.44	0.33	FALSE
21	GTEx	Breast Mammary Tissue	ARHGAP1	0.05	0.00	enet	14	0.01	1.3e-01	-3.71	5.6	2.4e-08	0.21	0.14	0.04	FALSE
22	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-6.80	-7.1	1.2e-12	-0.62	0.07	0.07	FALSE
23	GTEx	Breast Mammary Tissue (Female)	ACP2	0.03	0.00	lasso	1	0.02	1.0e-01	-11.30	11.3	9.8e-30	0.34	0.03	0.06	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	ACP2	0.17	0.03	lasso	6	0.03	4.2e-02	-4.64	11.1	1.6e-28	0.30	0.34	0.04	TRUE
25	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	12.45	-11.2	7.1e-29	-0.92	0.05	0.95	FALSE
26	GTEx	Cells Transformed fibroblasts	PACSIN3	0.07	0.00	enet	7	0.01	1.2e-01	-7.24	6.8	1.1e-11	0.26	0.12	0.05	FALSE
27	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	-4.77	5.3	1.4e-07	0.75	0.12	0.44	FALSE
28	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-4.77	6.4	1.2e-10	0.70	0.25	0.20	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	7.94	-13.9	3.8e-44	-0.49	0.18	0.36	TRUE
30	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	-9.47	9.8	1.2e-22	0.21	0.82	0.01	TRUE
31	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-7.96	-10.6	3.6e-26	-0.68	0.45	0.21	FALSE
32	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	3.97	-5.3	9.3e-08	-0.27	0.73	0.01	FALSE
33	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	-4.77	7.6	3.0e-14	0.81	0.26	0.70	FALSE
34	GTEx	Esophagus Muscularis	CKAP5	0.05	0.03	lasso	4	0.04	3.3e-03	-6.00	-5.6	1.9e-08	-0.25	0.43	0.03	FALSE
35	GTEx	Esophagus Muscularis	ARHGAP1	0.07	0.08	lasso	3	0.07	6.1e-05	-6.00	5.7	1.2e-08	0.18	0.86	0.02	FALSE
36	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-4.81	7.3	2.6e-13	0.76	0.82	0.16	FALSE
37	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-10.96	5.5	4.2e-08	-0.26	0.46	0.04	FALSE
38	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	-10.96	7.6	3.0e-14	0.13	0.80	0.02	FALSE
39	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	-4.72	5.4	5.7e-08	0.13	0.22	0.03	FALSE
40	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-4.81	7.9	3.8e-15	0.70	0.25	0.55	FALSE
41	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	-4.42	7.6	3.4e-14	0.08	0.55	0.03	FALSE
42	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-6.57	6.9	5.9e-12	0.65	1.00	0.00	FALSE
43	GTEx	Muscle Skeletal	FNBP4	0.05	0.03	lasso	5	0.04	5.0e-05	-10.13	-13.8	3.1e-43	-0.81	0.05	0.92	FALSE
44	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-4.81	5.8	5.2e-09	0.72	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	CELF1	0.08	0.02	enet	15	0.06	4.3e-05	10.04	-10.6	1.8e-26	-0.59	0.12	0.48	FALSE
46	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	-4.11	5.7	1.4e-08	0.13	0.91	0.02	FALSE
47	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	10.22	-10.6	3.8e-26	-0.64	0.46	0.31	FALSE
48	GTEx	Prostate	CELF1	0.17	0.16	lasso	2	0.12	6.2e-04	-7.41	-7.4	1.3e-13	-0.29	0.19	0.06	FALSE
49	GTEx	Prostate	ZNF408	0.19	0.10	lasso	2	0.10	1.6e-03	-7.37	6.3	3.8e-10	0.22	0.14	0.07	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	DDB2	0.07	0.02	enet	13	0.04	3.5e-03	-4.42	-5.3	1.0e-07	-0.15	0.15	0.05	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	SLC39A13	0.07	0.11	lasso	2	0.10	5.2e-06	-10.13	-10.1	3.7e-24	-0.34	0.31	0.20	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-4.81	5.5	5.1e-08	0.71	0.95	0.05	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	ARHGAP1	0.06	0.01	lasso	9	0.00	2.8e-01	-7.37	6.0	1.6e-09	0.21	0.16	0.08	FALSE
54	GTEx	Skin Sun Exposed Lower leg	PTPMT1	0.13	0.01	enet	33	0.03	3.0e-03	-9.47	-6.2	6.8e-10	-0.41	0.16	0.22	FALSE
55	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	-3.94	-5.5	3.1e-08	-0.17	1.00	0.00	FALSE
56	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-4.81	8.8	9.2e-19	0.82	1.00	0.00	FALSE
57	GTEx	Spleen	ACP2	0.19	-0.01	lasso	5	0.04	4.1e-02	-6.79	6.4	1.2e-10	0.11	0.12	0.05	FALSE
58	GTEx	Spleen	PTPRJ	0.22	0.05	lasso	5	0.03	7.5e-02	6.09	6.4	1.7e-10	-0.17	0.07	0.10	FALSE
59	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-7.69	10.4	3.5e-25	0.84	0.30	0.68	FALSE
60	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	-5.59	5.6	2.7e-08	-0.03	0.61	0.03	FALSE
61	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-6.73	-6.7	1.6e-11	-0.60	1.00	0.00	FALSE
62	GTEx	Testis	LRP4	0.17	0.00	lasso	3	-0.01	7.8e-01	-5.70	5.2	2.1e-07	0.24	0.04	0.17	FALSE
63	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	12.59	12.8	9.8e-38	0.97	0.04	0.96	FALSE
64	GTEx	Thyroid	ACP2	0.19	0.14	lasso	4	0.12	3.0e-09	-8.61	7.8	5.1e-15	0.14	1.00	0.00	FALSE
65	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-7.75	7.8	7.6e-15	0.63	0.61	0.06	FALSE
66	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-8.07	7.4	1.0e-13	0.59	1.00	0.00	FALSE
67	METSIM	Adipose	DDB2	0.03	0.03	lasso	2	0.02	1.9e-04	-5.94	6.2	4.6e-10	0.23	0.84	0.00	FALSE
68	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	-6.73	6.1	8.6e-10	0.59	1.00	0.00	FALSE
69	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	8.79	-10.8	5.8e-27	-0.39	0.68	0.07	FALSE
70	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	-9.47	7.6	3.0e-14	0.10	0.48	0.01	FALSE
71	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	-6.79	8.8	1.8e-18	0.21	0.32	0.02	FALSE
72	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-7.96	8.0	1.7e-15	0.64	1.00	0.00	FALSE
73	NTR	Blood	PTPRJ	0.04	0.01	blup	285	0.02	8.5e-08	-6.24	-6.5	8.9e-11	-0.45	0.99	0.00	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	NR1H3	0.06	0.01	blup	302	0.04	1.5e-05	-9.47	-8.5	2.7e-17	-0.33	0.83	0.05	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-8.07	-7.8	5.9e-15	-0.66	1.00	0.00	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	12.60	-12.7	7.8e-37	-0.95	0.04	0.96	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	PTPMT1	0.03	0.02	blup	270	0.02	3.8e-04	-10.13	-7.0	2.1e-12	-0.28	0.62	0.02	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	-6.76	-8.5	2.0e-17	-0.26	0.70	0.29	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	DDB2	0.04	0.03	enet	15	0.03	7.1e-05	-7.34	8.6	9.9e-18	0.40	0.92	0.01	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	-4.26	-6.9	6.1e-12	-0.15	0.92	0.00	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	ZNF408	0.04	0.02	blup	243	0.03	5.0e-05	-5.92	6.5	8.1e-11	0.24	0.90	0.01	FALSE
82	YFS	Blood	CKAP5	0.01	0.01	bslmm	291	0.01	3.6e-03	2.37	-5.7	9.3e-09	-0.38	0.04	0.02	FALSE
83	YFS	Blood	DDB2	0.02	0.00	bslmm	306	0.01	1.9e-04	-11.04	6.2	4.2e-10	0.23	0.25	0.02	FALSE
84	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	10.06	-8.2	2.7e-16	-0.65	0.19	0.71	FALSE
85	YFS	Blood	PHF21A	0.01	0.01	bslmm	385	0.00	1.9e-02	-5.43	-5.3	1.1e-07	-0.10	0.69	0.01	TRUE
86	YFS	Blood	PTPMT1	0.03	0.01	lasso	5	0.01	3.2e-04	12.50	9.4	7.2e-21	0.82	0.04	0.95	FALSE
87	YFS	Blood	PTPRJ	0.02	0.01	bslmm	281	0.02	2.8e-06	-6.20	-6.5	5.7e-11	-0.33	0.46	0.05	FALSE
88	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	-6.57	5.8	6.9e-09	0.47	1.00	0.00	FALSE
89	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-8.12	7.4	1.6e-13	0.67	0.21	0.76	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-10.51	-5.2	2.5e-07	0.10	0.07	0.02	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-6.57	8.9	8.1e-19	0.65	0.20	0.16	FALSE
92	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	12.59	-10.9	8.2e-28	-0.96	0.02	0.84	FALSE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	11.07	-13.7	5.9e-43	-0.82	0.02	0.80	FALSE
94	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-4.81	5.9	3.8e-09	0.73	0.51	0.49	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACP2	0.02	0.03	lasso	1	0.02	1.5e-03	-8.61	8.6	7.3e-18	0.20	0.04	0.48	FALSE
96	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-8.07	8.0	8.8e-16	0.63	0.98	0.02	FALSE
97	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-7.70	-6.2	7.8e-10	-0.24	0.38	0.05	FALSE
98	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	-4.38	6.5	5.9e-11	0.59	0.61	0.25	TRUE
99	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PSMC3	0.05	0.01	lasso	3	0.02	9.4e-04	6.11	-8.3	7.3e-17	-0.24	0.04	0.08	FALSE
100	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	-5.59	7.0	2.3e-12	0.06	0.19	0.76	FALSE
101	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-8.07	7.0	1.9e-12	0.69	1.00	0.00	FALSE
102	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-7.97	8.0	1.6e-15	0.64	0.84	0.16	FALSE
103	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NUP160	0.13	0.05	lasso	4	0.04	2.6e-03	-6.24	6.2	4.4e-10	0.43	0.07	0.23	FALSE
104	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-6.83	-6.8	1.0e-11	-0.61	0.32	0.20	FALSE
105	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-8.07	-8.1	6.2e-16	-0.63	1.00	0.00	FALSE
106	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYBPC3	0.03	0.01	blup	43	0.02	3.2e-03	-6.67	7.1	1.2e-12	0.62	0.06	0.06	FALSE
107	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-8.07	8.1	6.2e-16	0.63	0.99	0.01	FALSE
108	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-4.81	5.8	8.8e-09	0.69	0.05	0.60	FALSE
109	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC39A13	0.06	0.01	blup	58	0.04	9.3e-04	4.35	-8.6	8.5e-18	-0.52	0.04	0.04	FALSE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	AGBL2	0.04	0.03	blup	49	0.03	7.8e-04	11.12	-12.4	4.1e-35	-0.88	0.02	0.88	FALSE
111	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.73	-8.8	1.6e-18	-0.73	0.06	0.38	FALSE
112	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-8.14	7.3	2.3e-13	0.66	0.05	0.25	FALSE
113	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	-10.78	7.9	3.6e-15	0.18	0.02	0.78	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	DDB2	0.06	0.04	enet	17	0.03	1.3e-03	-11.03	-8.7	3.6e-18	-0.20	0.00	1.00	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	-9.47	7.0	2.2e-12	0.07	0.01	0.77	FALSE
116	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF408	0.27	0.01	blup	27	0.09	1.5e-03	-5.45	7.4	1.1e-13	0.26	0.01	0.70	FALSE