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chr16:661,142-5,627,737

Best TWAS P=3.84e-23 · Best GWAS P=3.02e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GLYR1	0.14	0.03	bslmm	416	0.07	3.8e-09	-4.1	9.9	3.8e-23	-0.45	0.21	0.76	TRUE
2	CommonMind	Brain Pre-frontal Cortex	RNPS1	0.11	0.05	enet	14	0.05	5.3e-07	-4.7	6.1	1.1e-09	-0.01	0.99	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC9A3R2	0.15	0.09	enet	7	0.10	7.8e-12	-6.9	7.0	3.6e-12	0.05	0.02	0.98	TRUE
4	CommonMind	Brain Pre-frontal Cortex	UBE2I	0.05	0.05	lasso	2	0.04	1.7e-05	5.8	-6.0	2.7e-09	0.02	0.20	0.77	FALSE
5	CommonMind	Brain Pre-frontal Cortex	ZNF500	0.11	0.07	enet	34	0.09	2.1e-11	-4.1	-5.8	8.1e-09	0.32	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	MGRN1	0.33	0.33	enet	25	0.38	3.3e-33	-5.1	5.4	6.0e-08	-0.29	1.00	0.00	FALSE
7	GTEx	Adipose Subcutaneous	RP11-95P2.1	0.12	0.01	lasso	3	0.02	1.0e-02	3.1	-5.4	6.8e-08	0.05	0.03	0.50	FALSE
8	GTEx	Adipose Visceral Omentum	MGRN1	0.22	0.17	enet	11	0.21	5.0e-11	-5.1	5.8	8.2e-09	-0.18	1.00	0.00	FALSE
9	GTEx	Adrenal Gland	ZNF500	0.11	0.07	enet	15	0.01	9.6e-02	-6.2	-7.2	9.0e-13	0.36	0.09	0.35	TRUE
10	GTEx	Artery Aorta	UBN1	0.18	0.15	lasso	4	0.14	6.8e-08	-5.6	5.7	9.7e-09	-0.80	0.13	0.87	FALSE
11	GTEx	Artery Tibial	MGRN1	0.38	0.34	enet	31	0.39	1.3e-32	-5.6	5.5	2.9e-08	-0.16	1.00	0.00	FALSE
12	GTEx	Artery Tibial	UBE2I	0.13	0.15	lasso	3	0.15	1.4e-11	6.0	-6.1	1.1e-09	0.02	0.13	0.87	TRUE
13	GTEx	Artery Tibial	UBN1	0.20	0.06	lasso	7	0.07	4.8e-06	-4.9	5.5	3.9e-08	-0.75	0.83	0.16	FALSE
14	GTEx	Artery Tibial	CCDC154	0.29	0.17	enet	12	0.26	1.0e-20	5.3	5.4	8.4e-08	0.01	0.88	0.12	TRUE
15	GTEx	Brain Caudate basal ganglia	MIR940	0.22	0.13	lasso	3	0.14	5.8e-05	-4.4	-5.2	2.7e-07	0.02	0.49	0.09	FALSE
16	GTEx	Brain Cerebellar Hemisphere	MGRN1	0.61	0.58	enet	17	0.55	7.3e-17	-4.6	5.1	3.0e-07	-0.18	1.00	0.00	FALSE
17	GTEx	Brain Cerebellar Hemisphere	ZNF500	0.27	0.13	enet	13	0.12	4.4e-04	-4.1	-7.0	2.0e-12	0.47	0.19	0.52	FALSE
18	GTEx	Brain Cerebellum	ZNF500	0.44	0.20	enet	24	0.21	8.0e-07	-4.1	-5.2	2.4e-07	0.16	0.90	0.02	FALSE
19	GTEx	Brain Cerebellum	HMOX2	0.21	0.15	lasso	3	0.14	7.2e-05	5.1	5.1	2.7e-07	0.03	0.55	0.02	FALSE
20	GTEx	Brain Cerebellum	ABCA3	0.32	0.06	lasso	2	0.05	1.2e-02	-5.5	6.2	6.3e-10	-0.04	0.08	0.05	FALSE
21	GTEx	Brain Cortex	NUBP2	0.21	0.00	lasso	5	-0.01	4.9e-01	6.0	5.7	1.1e-08	0.00	0.06	0.16	FALSE
22	GTEx	Brain Cortex	ZNF500	0.18	0.02	enet	8	0.04	2.5e-02	4.4	-6.5	6.4e-11	0.51	0.07	0.17	FALSE
23	GTEx	Brain Cortex	AC006111.1	0.32	0.02	enet	16	0.00	3.2e-01	-4.4	8.0	1.8e-15	-0.03	0.04	0.06	TRUE
24	GTEx	Brain Cortex	MIR940	0.32	0.14	lasso	6	0.19	6.1e-06	-4.4	-5.4	6.5e-08	0.03	0.48	0.03	FALSE
25	GTEx	Brain Frontal Cortex BA9	MIR940	0.36	0.17	lasso	4	0.11	6.3e-04	-4.7	-5.5	4.5e-08	0.02	0.12	0.08	FALSE
26	GTEx	Brain Hypothalamus	MGRN1	0.28	0.15	lasso	7	0.15	2.8e-04	-5.1	5.4	7.5e-08	-0.19	0.28	0.12	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	MGRN1	0.39	0.25	lasso	5	0.26	1.4e-07	-5.8	5.7	9.8e-09	-0.17	0.98	0.00	FALSE
28	GTEx	Brain Putamen basal ganglia	ROGDI	0.41	0.38	lasso	7	0.30	7.9e-08	-5.2	5.4	8.1e-08	-0.74	0.08	0.91	FALSE
29	GTEx	Brain Putamen basal ganglia	MGRN1	0.50	0.34	enet	25	0.46	2.1e-12	-4.7	5.3	1.2e-07	-0.13	0.80	0.08	FALSE
30	GTEx	Breast Mammary Tissue	ZNF500	0.18	0.10	lasso	3	0.10	5.0e-06	-6.2	-5.7	1.0e-08	0.19	0.98	0.00	FALSE
31	GTEx	Breast Mammary Tissue	UBN1	0.21	0.05	enet	29	0.09	1.9e-05	-3.6	6.5	5.8e-11	-0.49	0.32	0.12	TRUE
32	GTEx	Breast Mammary Tissue (Female)	HAGH	0.13	0.00	enet	11	0.01	2.0e-01	3.1	5.5	4.7e-08	0.02	0.11	0.07	TRUE
33	GTEx	Breast Mammary Tissue (Female)	MGRN1	0.45	0.20	enet	13	0.21	8.9e-07	-5.6	5.5	4.5e-08	-0.20	0.98	0.00	FALSE
34	GTEx	Breast Mammary Tissue (Female)	ZNF500	0.14	0.10	lasso	3	0.05	1.7e-02	-5.0	-5.4	8.2e-08	0.18	0.26	0.05	FALSE
35	GTEx	Cells Transformed fibroblasts	ANKS3	0.09	0.05	enet	22	0.03	2.7e-03	-6.2	-5.2	2.1e-07	0.35	0.33	0.38	TRUE
36	GTEx	Cells Transformed fibroblasts	MIR940	0.16	0.10	enet	13	0.10	4.7e-08	-3.9	-5.4	5.7e-08	0.04	0.99	0.00	FALSE
37	GTEx	Colon Transverse	MGRN1	0.47	0.19	lasso	10	0.26	1.5e-12	-4.9	5.5	4.6e-08	-0.17	1.00	0.00	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	MGRN1	0.36	0.25	enet	8	0.20	8.3e-08	-5.6	5.4	6.3e-08	-0.20	0.99	0.01	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	RNPS1	0.24	-0.01	enet	20	0.01	1.9e-01	-4.7	7.3	2.0e-13	-0.05	0.05	0.09	TRUE
40	GTEx	Esophagus Mucosa	UBN1	0.12	0.06	lasso	3	0.08	5.1e-06	-5.4	5.6	2.6e-08	-0.78	0.26	0.73	FALSE
41	GTEx	Esophagus Muscularis	MGRN1	0.30	0.18	enet	17	0.22	3.0e-13	-5.0	6.2	7.6e-10	-0.28	1.00	0.00	FALSE
42	GTEx	Esophagus Muscularis	CLCN7	0.27	0.20	lasso	5	0.18	8.0e-11	4.8	-5.6	1.8e-08	0.00	0.98	0.02	TRUE
43	GTEx	Esophagus Muscularis	UBE2I	0.20	0.10	enet	16	0.09	5.1e-06	6.0	-6.8	1.4e-11	0.01	0.13	0.87	FALSE
44	GTEx	Esophagus Muscularis	UBN1	0.18	0.19	lasso	4	0.19	9.1e-12	-5.6	5.5	3.7e-08	-0.82	0.98	0.02	FALSE
45	GTEx	Esophagus Muscularis	LA16c-390E6.4	0.12	0.09	lasso	7	0.05	3.8e-04	4.8	-5.4	5.2e-08	-0.02	0.48	0.36	FALSE
46	GTEx	Heart Atrial Appendage	MGRN1	0.33	0.30	enet	13	0.32	7.1e-15	-4.5	6.2	5.0e-10	-0.13	1.00	0.00	FALSE
47	GTEx	Heart Atrial Appendage	NUDT16L1	0.12	0.17	lasso	1	0.17	4.8e-08	-6.2	6.2	4.9e-10	-0.16	0.87	0.02	TRUE
48	GTEx	Heart Left Ventricle	MGRN1	0.32	0.10	enet	18	0.33	3.6e-18	3.4	7.1	1.4e-12	-0.09	0.98	0.00	FALSE
49	GTEx	Lung	ZNF500	0.12	0.08	lasso	5	0.08	9.9e-07	-4.1	-5.3	1.3e-07	0.30	0.96	0.00	FALSE
50	GTEx	Lung	UBN1	0.08	0.00	enet	20	0.01	9.2e-02	-3.6	5.3	1.1e-07	-0.48	0.05	0.32	FALSE
51	GTEx	Muscle Skeletal	MGRN1	0.16	0.06	lasso	7	0.15	1.1e-14	4.3	7.2	6.4e-13	-0.08	0.99	0.00	FALSE
52	GTEx	Nerve Tibial	UBN1	0.14	0.12	lasso	4	0.11	5.6e-08	-5.7	5.8	8.7e-09	-0.81	0.52	0.48	FALSE
53	GTEx	Prostate	MGRN1	0.35	0.16	enet	10	0.20	1.2e-05	-5.1	5.3	1.4e-07	-0.19	0.90	0.01	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	MGRN1	0.17	0.15	lasso	2	0.16	3.2e-09	-5.6	5.6	1.7e-08	-0.19	1.00	0.00	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	UBN1	0.22	0.16	lasso	4	0.14	2.5e-08	-5.8	6.0	2.6e-09	-0.78	0.75	0.24	FALSE
56	GTEx	Skin Sun Exposed Lower leg	UBN1	0.16	0.15	lasso	5	0.17	9.5e-14	-5.6	7.0	2.3e-12	-0.85	0.09	0.91	FALSE
57	GTEx	Skin Sun Exposed Lower leg	CCDC154	0.31	0.18	enet	7	0.22	2.8e-18	4.8	5.2	1.6e-07	0.01	0.96	0.04	FALSE
58	GTEx	Skin Sun Exposed Lower leg	LA16c-390E6.4	0.17	0.12	enet	12	0.13	5.0e-11	4.8	-5.2	2.2e-07	-0.04	0.98	0.01	TRUE
59	GTEx	Skin Sun Exposed Lower leg	LA16c-358B7.3	0.12	0.11	lasso	2	0.11	2.8e-09	6.7	-6.9	5.8e-12	-0.01	0.00	1.00	TRUE
60	GTEx	Spleen	MGRN1	0.55	0.45	lasso	3	0.42	4.3e-12	-5.1	5.2	2.2e-07	-0.18	0.99	0.00	FALSE
61	GTEx	Stomach	MGRN1	0.34	0.18	enet	14	0.22	1.2e-10	-4.3	5.2	2.5e-07	-0.23	1.00	0.00	FALSE
62	GTEx	Testis	ROGDI	0.17	0.09	enet	10	0.10	2.1e-05	-4.7	5.6	2.6e-08	-0.64	0.18	0.60	FALSE
63	GTEx	Testis	NUDT16L1	0.38	0.49	enet	16	0.38	5.9e-18	-6.2	-5.9	3.2e-09	0.18	1.00	0.00	FALSE
64	GTEx	Thyroid	MGRN1	0.30	0.24	enet	32	0.33	6.8e-26	-4.4	5.7	1.3e-08	-0.28	1.00	0.00	FALSE
65	GTEx	Thyroid	HMOX2	0.12	0.06	lasso	3	0.04	3.3e-04	4.3	5.1	2.7e-07	0.00	0.29	0.03	FALSE
66	GTEx	Uterus	MGRN1	0.31	0.13	enet	7	0.05	3.4e-02	-6.2	5.8	5.3e-09	-0.19	0.13	0.07	FALSE
67	METSIM	Adipose	ADCY9	0.07	0.02	bslmm	409	0.04	1.0e-06	-4.3	-7.6	4.2e-14	-0.03	0.96	0.01	TRUE
68	METSIM	Adipose	NUDT16L1	0.06	0.03	bslmm	392	0.04	2.2e-06	-4.6	-8.0	8.8e-16	0.36	0.98	0.01	TRUE
69	METSIM	Adipose	ZNF598	0.09	0.05	lasso	8	0.06	4.9e-09	5.6	-6.0	2.6e-09	0.04	0.92	0.04	TRUE
70	NTR	Blood	ADCY9	0.08	0.04	enet	11	0.06	3.1e-18	-4.3	-5.2	2.1e-07	-0.02	1.00	0.00	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	SLC9A3R2	0.16	0.11	lasso	6	0.12	6.3e-15	-6.9	6.4	1.9e-10	0.04	0.02	0.98	TRUE
72	ROSMAP	Brain Pre-frontal Cortex	ROGDI	0.26	0.30	enet	27	0.30	5.2e-39	5.4	6.2	5.2e-10	-0.69	1.00	0.00	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	GFER	0.15	0.09	enet	21	0.12	1.2e-14	-4.1	5.5	4.0e-08	-0.07	1.00	0.00	TRUE
74	ROSMAP	Brain Pre-frontal Cortex	SEPT12	0.40	0.47	enet	29	0.48	7.1e-71	5.1	-6.5	8.7e-11	0.72	1.00	0.00	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	GLYR1	0.11	0.04	lasso	6	0.06	3.8e-08	6.8	7.2	4.6e-13	-0.57	0.71	0.28	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	RPS2	0.07	0.02	blup	422	0.03	2.9e-04	-4.3	5.9	4.2e-09	-0.05	0.18	0.07	TRUE
77	ROSMAP	Brain Pre-frontal Cortex	ANKS3	0.08	0.00	blup	396	0.02	1.5e-03	-3.8	-7.6	2.4e-14	0.51	0.13	0.40	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	RP11-127I20.5	0.31	0.32	bslmm	374	0.40	2.0e-55	-4.9	-6.1	1.1e-09	0.72	1.00	0.00	FALSE
79	YFS	Blood	MGRN1	0.10	0.06	enet	12	0.08	1.4e-25	-4.9	5.4	8.2e-08	-0.18	1.00	0.00	FALSE
80	YFS	Blood	UBE2I	0.09	0.04	lasso	6	0.05	9.8e-15	6.1	6.5	7.1e-11	-0.02	0.07	0.93	FALSE
81	YFS	Blood	ZNF500	0.05	0.05	enet	16	0.06	1.6e-17	-4.1	-5.2	1.6e-07	0.44	1.00	0.00	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ZNF500	0.06	0.00	enet	10	0.03	3.1e-03	6.7	-6.3	2.8e-10	0.63	0.00	0.95	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf71	0.01	0.01	blup	52	0.01	3.1e-03	-4.4	-6.0	2.6e-09	0.33	0.03	0.86	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	NAT15	0.05	0.04	blup	56	0.03	1.7e-07	4.4	-5.8	7.5e-09	0.08	0.04	0.96	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROGDI	0.02	0.01	blup	39	0.02	7.7e-05	5.4	5.2	2.0e-07	-0.69	0.02	0.98	TRUE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPT12	0.11	0.04	enet	15	0.09	1.7e-17	6.6	-5.7	1.0e-08	0.44	0.77	0.23	FALSE
87	The Cancer Genome Atlas	Colon Adenocarcinoma	UBN1	0.05	0.04	enet	7	0.05	4.2e-04	8.5	-9.2	2.3e-20	0.79	0.03	0.68	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBE2I	0.02	0.03	lasso	3	0.02	3.4e-03	6.0	6.0	2.2e-09	-0.01	0.07	0.51	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GLYR1	0.05	0.02	lasso	3	0.02	8.5e-04	-6.1	5.6	2.3e-08	-0.19	0.52	0.02	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MGRN1	0.04	0.01	blup	53	0.01	1.4e-02	-5.6	5.5	4.9e-08	-0.24	0.02	0.78	FALSE
91	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRAP1	0.11	0.01	blup	43	0.05	9.4e-04	-1.8	5.8	6.9e-09	0.00	0.03	0.07	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	CORO7	0.26	0.43	lasso	3	0.44	5.0e-54	5.2	-5.4	5.5e-08	-0.02	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CCDC154	0.08	0.06	lasso	2	0.08	1.3e-04	4.6	5.2	2.3e-07	-0.01	0.00	0.97	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	GLYR1	0.07	0.04	blup	69	0.03	6.0e-05	-5.8	5.6	2.5e-08	-0.19	0.69	0.02	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	NAT15	0.06	0.04	blup	56	0.04	4.1e-05	7.0	-6.9	4.7e-12	0.09	0.00	1.00	TRUE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NAT15	0.04	0.01	blup	56	0.04	4.2e-05	3.8	-5.9	3.2e-09	0.05	0.01	0.96	FALSE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NAT15	0.30	0.19	blup	56	0.20	1.2e-08	3.8	-5.3	1.1e-07	0.06	0.06	0.93	FALSE
98	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MGRN1	0.08	0.14	lasso	3	0.12	1.6e-05	-5.0	5.2	2.2e-07	-0.19	0.05	0.89	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEPT12	0.13	0.10	enet	9	0.10	4.2e-11	5.4	-6.7	2.2e-11	0.64	0.14	0.86	TRUE
100	The Cancer Genome Atlas	Soft Tissue Sarcoma	NAT15	0.20	0.08	enet	14	0.17	1.8e-10	7.0	-5.5	5.0e-08	0.06	0.00	1.00	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	MGRN1	0.11	0.04	blup	54	0.07	1.5e-07	-6.1	5.3	9.9e-08	-0.24	0.01	0.99	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	NAT15	0.10	0.05	lasso	6	0.07	6.1e-07	5.1	-5.4	7.0e-08	0.05	0.11	0.88	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	SLC9A3R2	0.06	0.03	lasso	5	0.03	3.7e-04	-6.9	5.3	9.3e-08	0.02	0.02	0.90	TRUE