TWAS hub - RPS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.3660	0.0650	1.3e-07	0.238	NA	0.202	NA	0.228	7.4e-18	NA	4.0e-15	NA	4.5e-17
2	GTEx	Esophagus Mucosa	0.3580	0.0850	9.6e-05	0.173	NA	0.197	NA	0.180	1.1e-11	NA	3.0e-13	NA	3.9e-12
3	GTEx	Testis	0.3280	0.0810	4.8e-04	0.299	NA	0.248	NA	0.285	9.2e-14	NA	2.2e-11	NA	4.5e-13
4	ROSMAP	Brain Pre-frontal Cortex	0.0731	0.0278	2.1e-03	0.018	0.025	0.003	0.024	0.015	2.0e-03	2.9e-04	1.2e-01	3.7e-04	4.3e-03
5	YFS	Blood	0.0960	0.0247	4.9e-09	0.042	0.030	0.059	0.063	0.062	1.3e-13	2.7e-10	1.4e-18	7.6e-20	1.7e-19
6	TCGA	Breast Invasive Carcinoma	0.0549	0.0209	1.3e-05	0.017	0.030	0.030	NA	0.030	1.3e-04	7.2e-07	8.3e-07	NA	6.2e-07
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0337	0.0213	9.3e-03	-0.002	0.005	0.000	NA	-0.002	5.4e-01	8.0e-02	2.8e-01	NA	8.8e-01
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0549	0.0229	9.8e-05	0.008	0.035	0.018	NA	0.010	4.1e-02	7.5e-05	3.8e-03	NA	2.1e-02
9	TCGA	Liver Hepatocellular Carcinoma	0.1120	0.0570	4.2e-03	0.002	0.052	0.042	NA	0.014	2.5e-01	1.8e-03	4.5e-03	NA	6.7e-02
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.1590	0.0670	5.8e-04	0.049	0.036	0.045	NA	0.028	3.2e-04	1.8e-03	4.9e-04	NA	5.5e-03
11	TCGA	Pancreatic Adenocarcinoma	0.1430	0.0680	4.8e-03	-0.007	0.063	0.042	NA	-0.004	9.8e-01	1.3e-03	7.5e-03	NA	5.0e-01
12	TCGA	Prostate Adenocarcinoma	0.0934	0.0373	1.4e-04	0.002	0.018	0.010	NA	0.019	1.7e-01	4.4e-03	3.1e-02	NA	3.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Hearing difficulty/problems: Yes	5.0	7.6	14.0	-2.0	-1.7	-2.0	2.7	-3.7	-3.7	2.3	-3.2	-2.2	-0.4	-3.7	-3.4
Hearing aid user	4.1	4.6	9.5	-1.9	-0.9	-1.9	1.6	-2.4	-3.1	1.3	-2.3	-3.0	0.2	-2.9	-2.4
Illnesses of father: None of the above (group 1)	4.0	5.0	11.7	2.3	2.7	2.3	-1.0	2.4	3.2	0.1	1.6	0.8	1.6	3.4	2.8
Leg pain on walking	3.8	4.7	11.2	2.4	2.4	2.4	-1.8	2.9	3.3	-0.6	1.3	0.5	0.8	2.1	3.1
Depression (Nagel 2018)	3.6	5.5	14.7	-3.8	-2.9	-3.8	0.8	-1.6	-2.9	-1.5	-2.1	-1.0	-1.3	-0.9	-2.5
Medication: Atorvastatin	3.2	4.0	9.2	0.0	-0.1	0.0	2.4	-2.5	-2.2	3.0	-1.3	-2.7	0.4	-2.9	-2.0
Hearing difficulty/problems with background noise	3.1	4.9	9.0	-2.9	-2.6	-2.9	0.6	-3.0	-2.7	-0.4	-2.2	-0.8	-1.1	-1.7	-3.0
Supplements: Vitamin C	3.1	3.7	9.4	-1.1	-1.2	-1.1	0.6	-2.9	-2.1	0.3	-2.7	-1.8	1.4	-2.0	-3.1
Fractured/broken bones in last 5 years	3.1	4.0	12.8	-3.1	-3.6	-3.1	-0.5	-0.6	-2.2	-0.9	0.0	0.2	-2.7	0.3	-1.4
Age started oral contraceptive pill	2.8	3.5	10.9	-2.4	-1.7	-2.4	1.8	-1.9	-3.3	0.5	-0.2	-0.5	-1.3	-1.9	-2.0
Serious illness, injury or assault to yourself	2.5	3.0	8.2	-2.2	-1.8	-2.2	1.0	-2.1	-2.9	-0.2	-1.4	-0.3	-0.7	-1.4	-2.1
Commuting to job workplace: Walk	2.5	2.6	8.3	2.1	1.8	2.1	0.5	-0.8	1.2	0.9	-2.0	-1.7	2.9	-1.0	-0.0
Reaction Time	2.4	4.5	11.3	0.3	0.8	0.3	2.6	-2.7	-0.8	1.0	-2.4	-3.4	3.1	-2.3	-2.3
Happiness	2.4	2.9	13.7	-0.7	-0.4	-0.7	-1.5	1.9	1.6	-3.7	0.5	1.7	-0.3	2.6	1.2
Arm predicted mass (right)	2.4	12.4	38.2	-4.2	-5.7	-4.2	-0.3	0.5	-1.1	-6.2	2.1	3.9	-3.9	2.6	-0.6
Arm predicted mass (left)	2.4	12.4	38.6	-4.2	-5.6	-4.2	0.1	0.2	-1.3	-6.2	2.0	4.0	-3.7	2.7	-0.8
Trunk fat-free mass	2.3	13.4	46.1	-3.8	-5.8	-3.8	-0.4	1.0	-0.6	-6.8	2.3	4.4	-3.9	3.2	-0.2
Arm fat-free mass (left)	2.3	11.5	36.0	-4.1	-5.6	-4.1	0.3	0.0	-1.4	-6.0	1.8	3.7	-3.4	2.3	-1.0
Trunk predicted mass	2.2	12.8	44.4	-3.8	-5.7	-3.8	-0.4	0.9	-0.5	-6.7	2.2	4.3	-3.7	3.1	-0.2
Arm fat-free mass (right)	2.2	11.3	36.4	-4.0	-5.4	-4.0	0.1	0.3	-1.1	-6.0	1.9	3.7	-3.6	2.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	15.0	-2.4	-3.1	-2.4	0.4	0.8	-0.2	-3.9	1.8	2.9	-2.1	1.6	0.1
Lupus	2.1	3.1	12.2	2.1	1.5	2.1	1.9	-0.2	0.9	1.1	-1.9	-2.0	3.5	-1.1	0.3
Number of live births	2.1	3.0	6.0	0.3	-0.2	0.3	1.8	-2.3	-1.6	2.3	-2.5	-2.1	1.5	-2.0	-1.6
Hypothyroidism (self reported)	1.9	4.3	11.7	-3.4	-2.9	-3.4	-1.8	-1.1	-2.0	-2.2	-0.7	-0.6	-0.7	-0.8	-2.1
Whole body fat-free mass	1.9	10.9	36.5	-3.7	-5.2	-3.7	-0.2	0.4	-0.9	-6.0	1.8	3.9	-3.5	2.8	-0.6
Whole body water mass	1.9	10.9	37.5	-3.6	-5.2	-3.6	-0.3	0.5	-0.8	-6.1	1.8	3.9	-3.4	3.0	-0.5
Mother’s age at death	1.9	2.4	5.6	-0.9	-1.5	-0.9	1.6	-2.2	-1.8	0.3	-2.4	-1.6	0.5	-1.2	-2.1
Supplements: Calcium	1.9	2.1	5.4	2.3	1.1	2.3	-0.9	0.6	1.6	2.0	0.1	-0.4	1.6	0.8	1.3
Alzheimer’s Disease (in mother)	1.8	2.1	4.1	1.4	-0.1	1.4	-1.4	1.7	1.8	1.1	1.6	0.7	-1.0	2.0	2.0
Financial situation satisfaction	1.8	2.2	6.1	0.5	1.1	0.5	-1.6	2.5	2.0	-1.2	1.3	0.6	-0.8	2.2	1.9
Standing height	1.7	16.7	58.5	-3.1	-5.5	-3.1	2.3	1.5	0.6	-7.7	3.7	6.4	-4.0	3.6	0.7
Birth weight of first child	1.7	3.1	6.1	-1.9	-2.5	-1.9	2.0	-2.4	-1.6	-0.4	-1.9	0.1	-0.6	-1.6	-2.1
Illnesses of siblings: Diabetes	1.7	2.1	4.9	-2.0	-0.9	-2.0	1.2	-1.1	-2.1	-0.7	-0.3	0.5	-1.1	-2.2	-1.5
Basal metabolic rate	1.7	9.3	30.4	-3.6	-4.7	-3.6	-0.0	0.1	-1.1	-5.5	1.6	3.5	-3.2	2.6	-0.8
Height	1.6	29.9	69.6	-4.0	-5.9	-4.0	3.0	2.9	0.9	-8.3	6.3	8.3	-6.8	6.7	1.8
Hand grip strength (left)	1.6	4.3	16.4	-1.4	-4.1	-1.4	0.6	0.3	0.2	-3.5	0.7	2.4	-1.8	3.0	0.3
Length of working week for main job	1.6	1.8	3.3	1.8	0.9	1.8	-0.9	1.5	1.7	0.0	1.8	0.6	0.3	1.5	1.6
Family relationship satisfaction	1.6	2.0	7.5	-1.8	-1.4	-1.8	-0.6	0.7	-0.4	-2.7	0.8	1.6	-1.4	1.4	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.1	2.3	1.5	2.3	-1.4	0.4	1.8	1.4	0.6	0.1	1.0	0.6	0.9
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	4.0	2.0	1.6	2.0	-0.3	0.1	1.5	1.9	-0.8	-1.4	1.9	0.2	0.6
Prostate Cancer	1.5	2.1	6.4	-0.3	0.7	-0.3	1.4	-1.7	-1.0	1.9	-2.5	-2.0	1.3	-1.0	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.2	-2.0	-1.0	-2.0	0.6	-1.3	-2.0	-0.3	-1.7	-1.6	-0.3	-0.5	-1.8
Exposure to tobacco smoke outside home	1.5	2.0	5.1	-0.6	-0.9	-0.6	-1.6	2.1	0.7	-2.3	0.8	1.4	-1.9	1.0	1.4
Number of full brothers	1.5	1.9	6.4	-0.3	-1.2	-0.3	0.3	-1.6	-1.8	0.6	-1.3	-1.9	1.2	-2.5	-1.6
Comparative height size at age 10	1.5	8.4	30.9	-2.0	-3.8	-2.0	1.2	1.5	0.7	-5.6	2.1	4.8	-3.1	2.3	0.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.3	-1.8	-1.7	-1.8	0.2	-1.3	-1.6	-1.4	-1.1	0.9	-1.3	-0.1	-1.4
Average weekly spirits intake	1.4	1.7	4.8	-2.2	-1.9	-2.2	-1.0	-0.3	-1.2	-1.1	-0.1	-0.1	-1.4	0.3	-1.2
Frequency of depressed mood in last 2 weeks	1.4	2.0	5.7	-2.4	-2.1	-2.4	0.3	-0.3	-1.5	-1.4	-1.3	-0.5	-1.0	0.0	-0.9
Multivitamins +/- minerals	1.4	1.7	5.5	1.1	1.2	1.1	-0.1	1.8	1.5	-0.6	1.0	1.2	0.6	2.3	1.7
Impedance of arm (right)	1.4	6.3	24.2	3.5	4.9	3.5	2.0	0.3	1.8	3.2	-0.2	-0.8	2.6	-1.0	1.3
Impedance of arm (left)	1.4	6.2	23.7	3.5	4.9	3.5	1.8	0.1	1.6	3.6	-0.3	-1.1	2.3	-1.1	1.1
Blood clot in the leg (DVT)	1.4	1.8	4.1	-0.8	-1.2	-0.8	-1.5	-2.0	-1.9	1.0	-0.4	-1.2	0.0	-1.6	-1.8
Comparative body size at age 10	1.4	3.9	16.9	-2.3	-3.2	-2.3	-0.5	0.0	-1.0	-4.1	0.6	2.1	-1.7	0.8	-0.4
Shortness of breath walking on level ground	1.4	1.7	5.7	0.7	1.2	0.7	-1.0	1.9	2.4	-1.1	0.6	-0.1	0.6	1.7	1.7
Medication: Allopurinol	1.4	1.8	4.1	2.0	1.8	2.0	-1.4	0.1	2.0	1.4	-0.2	-0.2	1.4	0.1	0.7
Medication: Seretide 50 evohaler	1.4	1.6	6.0	1.3	1.4	1.3	-2.4	1.6	1.6	0.5	-0.0	-0.2	0.1	0.2	1.6
Mean time to correctly identify matches	1.4	2.6	6.8	-0.6	0.0	-0.6	1.6	-2.2	-1.1	0.7	-1.6	-2.6	2.0	-2.1	-2.1
Loneliness, isolation	1.4	1.9	4.8	-2.0	-1.0	-2.0	-0.4	-1.2	-1.9	-0.8	-2.2	-0.9	0.4	-0.4	-1.6
Long-standing illness, disability or infirmity	1.4	2.2	6.6	0.3	1.1	0.3	0.4	-1.6	-0.8	2.6	-1.8	-2.6	1.3	-1.5	-1.0
Alcohol drinker status: Never	1.4	1.7	4.9	0.5	0.3	0.5	-0.8	2.2	1.5	-1.3	1.4	1.9	-0.6	1.2	1.8
Heel T-Score	1.3	10.2	21.4	3.5	4.5	3.5	-4.6	-0.3	1.5	4.5	-2.3	-3.4	4.0	-0.1	0.5
Medication: Co-codamol	1.3	1.5	5.4	0.9	2.3	0.9	0.4	-0.2	0.0	2.3	-0.6	-2.0	1.1	-0.0	0.4
Hand grip strength (right)	1.3	3.6	12.1	-1.4	-3.3	-1.4	0.8	0.6	0.4	-3.5	0.6	2.1	-1.7	2.6	0.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.2	-1.2	-1.5	-1.2	0.7	-2.0	-1.8	-0.2	-0.9	-0.3	0.2	-1.5	-2.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	9.6	-1.6	-3.1	-1.6	-0.9	0.4	-0.9	-2.2	-0.0	1.2	-1.6	-0.0	-0.1
Glaucoma (self-reported)	1.3	1.5	4.0	-1.2	-0.8	-1.2	1.3	-1.0	-2.0	0.8	-1.0	-1.4	1.2	-0.8	-1.5
Number of full sisters	1.3	1.5	4.2	-1.3	-0.8	-1.3	0.8	-1.2	-1.6	-0.1	-2.1	-1.1	0.5	-1.2	-1.6
Qualifications: nursing, teaching	1.3	2.0	5.9	-2.0	-2.4	-2.0	-1.8	-0.3	-1.0	-2.1	0.1	0.2	-0.6	0.4	-1.1
Average weekly champagne plus white wine intake	1.3	1.8	4.5	-0.6	0.2	-0.6	-0.8	-1.9	-1.2	-0.0	-2.1	-0.8	2.1	-1.8	-1.8
Cholesterol lowering medication	1.3	1.9	6.3	0.3	0.8	0.3	1.5	-1.9	-1.1	2.0	-0.7	-1.0	0.7	-2.5	-1.7
Ovarian Cancer	1.2	1.6	5.6	1.2	1.1	1.2	-0.6	-0.4	0.7	1.6	-1.9	-1.3	2.4	-0.3	-0.0
HbA1C	1.2	1.3	3.2	1.4	1.8	1.4	-1.5	0.9	1.6	1.0	0.4	-0.7	0.7	0.7	0.8
LDL Cholesterol	1.2	1.9	4.8	-1.4	-0.8	-1.4	-1.6	-1.5	-2.2	1.0	-1.3	-0.7	-0.7	-1.0	-1.9
Average weekly fortified wine intake	1.2	1.4	3.7	0.0	-0.7	0.0	0.6	-1.7	-0.8	0.8	-1.0	-1.9	1.8	-1.0	-1.6
Taking other prescription medications	1.2	1.9	4.5	-0.9	-1.0	-0.9	0.6	-1.7	-1.9	1.3	-1.4	-1.4	0.0	-2.1	-1.8
Number of incorrect matches in round	1.2	1.9	7.1	-1.2	-2.7	-1.2	0.4	-1.5	-1.2	-0.7	-1.5	-1.0	0.3	-1.6	-1.6
Had other major operations	1.2	1.5	2.7	-1.5	-1.7	-1.5	0.3	-1.5	-1.2	-0.9	-1.4	-0.7	0.0	-1.2	-1.5
Noisy workplace	1.2	1.4	3.1	0.6	1.0	0.6	-1.2	1.8	1.5	-0.8	1.3	1.1	-0.9	1.2	1.7
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.6	-2.6	-1.9	-2.6	-1.4	-0.9	-1.0	-1.9	-0.5	-0.3	-0.6	-0.2	-1.6
Leg fat-free mass (right)	1.2	6.2	19.7	-3.1	-3.8	-3.1	-0.3	-0.3	-1.1	-4.4	0.9	2.8	-2.6	2.0	-1.0
Unable to work because of sickness or disability	1.2	1.5	4.2	1.4	1.5	1.4	-1.0	0.2	1.8	1.1	-0.3	-1.3	2.0	-0.5	0.9
Systolic Blood Pressure	1.1	5.4	34.5	1.3	-0.0	1.3	5.9	-0.1	1.2	0.6	-0.7	-2.6	1.7	-3.8	0.3
Leg fat-free mass (left)	1.1	6.0	18.7	-3.0	-3.7	-3.0	-0.1	-0.4	-1.1	-4.3	0.9	2.7	-2.6	2.0	-1.0
Qualifications: CSEs or equivalent	1.1	1.4	4.2	-0.1	0.4	-0.1	-0.7	2.1	1.9	-1.8	0.2	1.0	-0.5	1.3	1.6
Medication: Atenolol	1.1	1.4	4.7	-1.5	-2.2	-1.5	1.1	0.0	-0.6	-1.1	1.1	1.1	-1.3	-0.7	-0.5
Leg predicted mass (left)	1.1	6.1	19.4	-3.0	-3.8	-3.0	-0.2	-0.3	-1.1	-4.4	0.8	2.7	-2.6	2.1	-0.9
Pain all over the body in last month	1.1	1.1	2.2	1.5	1.3	1.5	-0.4	1.3	1.3	1.0	-0.6	-0.7	0.8	0.5	1.2
Alcohol intake versus 10 years previously	1.1	1.6	4.3	0.5	-0.2	0.5	-0.2	2.1	1.4	-2.1	0.9	1.6	-0.5	1.0	1.8
Pulse wave reflection index	1.1	1.4	3.6	-1.7	-1.1	-1.7	-0.0	-0.0	-1.2	-1.5	0.4	1.9	-1.2	-0.0	-0.7
Migraine (self-reported)	1.1	1.3	4.1	-0.5	-0.2	-0.5	-0.2	2.0	1.3	-1.8	1.1	1.0	-0.9	1.2	1.4
Osteoporosis (self-reported)	1.1	1.4	2.7	1.6	0.6	1.6	-1.1	1.0	1.5	1.0	1.1	1.1	-0.1	1.6	1.0
Leg predicted mass (right)	1.1	5.8	19.0	-2.9	-3.6	-2.9	-0.3	-0.2	-0.9	-4.4	0.9	2.8	-2.5	2.0	-0.9
Diastolic blood pressure, automated reading	1.1	3.5	12.6	-2.0	-2.5	-2.0	2.0	-0.7	-1.6	-1.1	-0.9	-2.0	-0.7	-3.6	-1.2
Mean Putamen Volume	1.0	1.2	2.2	-1.5	-0.2	-1.5	1.1	-1.2	-1.1	0.7	-1.3	-1.4	-0.6	-0.8	-0.9
Allergy or Eczema	1.0	2.5	6.0	1.2	0.6	1.2	-2.1	2.1	1.3	0.6	1.9	1.3	-0.6	2.4	2.2
Neuroticism score	1.0	2.2	8.3	-2.2	-1.3	-2.2	-0.8	1.3	-0.1	-2.9	0.0	1.1	-1.3	1.0	0.2
Mouth/teeth dental problems: Dentures	1.0	1.7	11.2	1.3	1.9	1.3	-0.3	0.3	0.3	3.3	0.2	-0.8	0.1	0.4	1.0
Gout (self-reported)	1.0	1.3	4.6	1.0	1.0	1.0	-2.1	1.0	1.8	0.3	1.4	0.7	-0.1	0.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.7	-0.5	-0.3	-0.5	0.3	-2.2	-0.8	1.3	-1.2	-1.2	0.4	-0.6	-1.8
Medication: Blood pressure	1.0	1.9	8.0	1.6	2.8	1.6	1.4	-0.2	1.3	1.2	0.1	-0.8	1.7	-0.2	0.2
Heart disease (mother)	1.0	1.2	4.1	-0.5	0.0	-0.5	1.8	-2.0	-1.2	0.9	-0.7	-0.7	0.0	-1.3	-1.4
Mineral and other dietary supplements	1.0	1.3	3.6	-1.3	0.2	-1.3	1.1	-1.5	-1.9	-0.1	-0.1	-0.6	-0.7	-1.4	-1.6
Heart disease (siblings)	1.0	1.2	3.1	-1.3	-1.7	-1.3	0.5	-0.3	-1.3	-1.2	0.1	0.1	-0.9	-1.8	-0.6
Alzheimer’s Disease (in father)	0.9	1.0	3.1	0.2	-0.0	0.2	1.2	-1.4	-0.9	1.3	-0.8	-0.7	0.7	-1.8	-1.1
Breast Cancer	0.9	2.1	4.3	-2.1	-2.0	-2.1	2.0	-0.6	-1.0	-1.2	0.0	0.8	-1.7	-0.9	-0.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	3.7	0.5	-0.2	0.5	-0.7	1.3	1.1	-1.6	0.9	1.9	-0.5	0.4	1.0
Sitting height	0.9	6.2	22.8	-2.3	-4.5	-2.3	2.3	0.5	-0.5	-4.8	0.8	3.0	-2.4	0.4	-0.0
High blood pressure (mother)	0.9	1.3	4.0	-0.1	-0.0	-0.1	0.5	-2.0	-0.7	0.7	-1.8	-1.5	0.4	-1.6	-1.5
Time employed in main current job	0.9	1.0	4.3	-0.6	-1.2	-0.6	0.3	0.5	-0.2	-0.2	1.6	1.4	-2.1	0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	8.6	-1.5	-2.9	-1.5	2.9	-1.7	-1.0	-2.6	0.0	0.6	-0.0	-0.6	-1.7
Loud music exposure frequency	0.9	1.0	2.8	-1.4	-0.7	-1.4	1.1	0.2	-0.9	-1.7	-0.8	0.9	-0.9	0.2	-0.4
Number of children fathered	0.9	1.0	3.1	1.3	0.6	1.3	-0.3	-0.6	0.3	1.8	-0.1	-1.3	1.5	0.5	-0.6
Emphysema/chronic bronchitis	0.9	1.1	2.8	1.1	1.3	1.1	-1.4	-0.2	1.0	0.5	-0.6	-1.4	1.7	-0.4	-0.0
Chest pain or discomfort	0.9	1.3	5.5	0.5	0.4	0.5	-0.6	1.2	1.0	0.0	2.3	1.3	-1.8	-0.4	1.0
Illnesses of father: Heart disease	0.9	1.3	4.0	-1.1	-1.8	-1.1	-1.3	-0.4	-1.0	-1.2	-0.1	-0.3	-1.0	-2.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.0	1.4	-0.0	1.4	-1.1	1.3	2.0	0.1	0.3	0.5	0.4	0.9	1.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	3.2	1.8	0.7	1.8	-1.5	0.2	1.0	0.4	0.2	0.7	0.7	1.0	0.7
Ever depressed for a whole week	0.9	1.1	5.2	-1.0	-0.8	-1.0	0.4	1.1	0.2	-2.3	0.6	0.9	-1.2	0.9	0.6
Commuting to job workplace: Cycle	0.9	1.1	2.4	-1.6	-1.6	-1.6	-0.9	0.0	-0.9	-1.1	0.1	0.8	-1.3	0.8	-0.3
Depressed Affect (Nagel 2018)	0.8	1.7	6.0	-2.5	-1.1	-2.5	0.4	-0.1	-0.7	-1.6	-1.9	-0.3	-0.4	0.4	-0.6
Worry (Nagel 2018)	0.8	1.6	4.1	-1.9	-1.5	-1.9	-0.6	1.3	0.0	-2.0	0.8	0.9	-1.1	0.8	0.4
Age at First Birth	0.8	1.1	4.4	-0.2	-0.1	-0.2	-1.0	1.3	0.6	-0.5	1.6	1.1	-0.7	2.1	0.9
Body Mass Index (BMI) (2010)	0.8	1.1	6.5	-0.7	-1.1	-0.7	-1.2	1.0	-0.3	0.0	2.6	1.1	0.0	1.2	0.0
Primary Biliary Cirrhosis	0.8	1.2	2.7	1.3	1.2	1.3	-0.0	1.4	1.6	0.1	1.0	0.5	0.1	0.6	1.6
Lung FVC	0.8	4.0	9.9	1.8	1.4	1.8	3.0	-1.4	0.5	2.3	-0.9	-3.1	3.1	-1.7	-0.5
Neuroticism	0.8	2.0	5.9	-2.4	-1.8	-2.4	0.3	0.7	-0.5	-2.4	-0.5	0.5	-1.0	0.7	-0.2
Medication for hormone replacement therapy	0.8	0.9	2.0	0.2	0.9	0.2	-1.4	1.4	1.1	-0.8	0.8	1.1	-0.5	0.3	1.3
Diabetes (father)	0.8	1.0	2.2	0.9	1.2	0.9	1.5	1.0	1.2	0.3	0.8	1.4	-0.9	0.4	1.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.7	1.3	1.3	1.3	-1.6	1.2	1.3	0.8	1.2	0.3	0.0	2.2	1.5
Supplements: Glucosamine	0.8	1.1	4.0	-0.9	-1.2	-0.9	-0.2	-1.2	-0.8	-0.2	-2.0	-0.5	0.7	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.9	-1.1	-1.9	-1.1	0.7	0.3	-0.1	-2.2	0.1	0.2	-0.8	0.2	-0.2
Weight	0.8	4.1	8.8	-2.7	-2.4	-2.7	0.9	-0.9	-1.8	-3.0	1.1	2.2	-2.0	1.6	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.6	-1.6	-1.0	-1.6	-1.0	0.1	-1.1	-1.0	0.6	0.2	-1.1	0.6	-0.3
Medication: Lansoprazole	0.8	0.9	4.8	1.2	0.9	1.2	-0.0	-0.4	0.4	2.2	-0.8	-1.1	0.7	0.2	0.3
Peak expiratory flow (PEF)	0.8	1.9	8.4	-1.4	-2.9	-1.4	0.9	-1.1	-1.0	-2.1	0.2	0.5	-1.0	-0.1	-1.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.7	0.4	-0.7	0.4	-1.2	1.5	1.6	-0.8	1.2	0.6	-0.5	1.5	1.7
Wheeze or whistling in the chest in last year	0.8	1.5	5.1	0.2	0.2	0.2	0.5	-1.5	-0.6	1.2	-2.0	-2.2	0.8	-1.7	-1.0
Medication: Ibuprofen	0.8	0.9	2.7	-1.4	-1.3	-1.4	-0.5	-0.1	-0.8	-1.7	0.1	0.6	-0.8	0.5	-0.4
Suffer from ‘nerves’	0.8	1.3	2.9	-1.3	-0.8	-1.3	-0.6	1.1	-0.0	-1.3	1.6	1.4	-1.7	0.8	0.6
Average weekly red wine intake	0.8	1.2	3.0	-1.3	-1.7	-1.3	0.8	-1.5	-1.3	-0.1	0.0	0.6	-0.9	-0.4	-1.4
Diabetes diagnosed by doctor	0.8	1.3	2.9	-1.0	-0.3	-1.0	0.4	-1.6	-1.5	0.9	-1.2	-0.7	0.0	-1.7	-1.6
Number of self-reported non-cancer illnesses	0.8	1.3	3.9	-1.0	-0.9	-1.0	0.1	-2.0	-1.0	0.3	-1.1	-1.1	-0.2	-1.5	-1.8
Irritability	0.8	1.3	3.6	-1.9	-0.6	-1.9	0.4	0.3	-0.5	-1.9	-0.3	1.4	-1.2	0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.9	-0.2	-0.7	-0.2	-2.0	-1.6	-1.2	0.9	-0.1	-0.9	0.2	-1.3	-1.3
Impedance of whole body	0.8	4.0	13.0	2.7	3.6	2.7	2.6	0.3	1.4	2.4	0.5	-0.3	1.6	-1.2	1.1
Rheumatoid Arthritis	0.7	0.9	5.4	-0.2	-0.6	-0.2	-2.3	0.3	0.6	-1.9	-0.7	-0.2	0.6	-0.2	0.1
Cardiovascular Disease	0.7	2.3	8.8	-0.9	-0.3	-0.9	2.2	-1.4	-0.6	-0.5	-0.9	-2.4	0.8	-3.0	-1.7
Chronotype (morning person)	0.7	1.6	3.7	0.7	0.5	0.7	-0.5	1.7	1.6	-1.0	1.0	1.7	-1.1	1.9	1.7
Systolic blood pressure, automated reading	0.7	2.2	12.6	0.2	-0.7	0.2	3.6	0.3	-0.2	1.1	0.7	-1.6	-0.2	-2.8	0.5
Townsend deprivation index at recruitment	0.7	1.0	2.9	0.5	1.7	0.5	0.9	-1.0	-1.0	1.3	0.2	-1.2	1.1	-1.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	6.1	1.0	2.4	1.0	-0.9	0.5	0.4	2.5	-0.7	-0.9	-0.2	1.8	0.7
Nervous feelings	0.7	1.4	3.7	-0.9	0.3	-0.9	-1.0	1.9	0.5	-1.9	1.0	1.4	-1.1	0.8	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.8	-1.4	-0.9	-1.4	-0.3	-0.3	-1.7	-0.4	-1.5	-1.1	0.3	-0.6	-1.1
Had menopause	0.7	0.9	2.9	0.3	0.4	0.3	1.0	1.4	0.3	1.7	1.1	0.6	-1.0	-0.2	1.2
Forced vital capacity (FVC)	0.7	2.8	14.4	-0.9	-2.6	-0.9	3.8	-1.5	-0.5	-2.5	-0.5	0.2	0.5	-0.6	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.0	-1.7	-1.1	-1.7	-0.9	-0.2	-1.6	-0.2	-0.5	-0.6	-0.3	-1.0	-0.8
Worry too long after embarrassment	0.7	1.1	2.9	-0.7	-0.8	-0.7	-1.6	1.7	0.5	-1.2	1.0	-0.4	-0.2	1.7	1.0
Pulse wave peak to peak time	0.7	0.9	3.3	-0.2	-0.3	-0.2	-1.3	0.7	0.8	-1.5	1.0	0.5	-0.4	1.8	0.5
Health satisfaction	0.7	0.9	2.3	0.3	0.6	0.3	-1.4	1.2	1.5	-1.1	0.1	-0.1	0.6	1.2	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.7	0.7	1.1	0.7	-0.9	1.1	1.2	-0.0	0.8	0.4	0.4	1.3	1.2
Arm fat percentage (left)	0.7	2.7	5.6	-0.0	2.2	-0.0	1.0	-2.3	-2.0	2.4	-1.5	-1.9	1.1	-1.1	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.3	-0.8	-1.5	-0.8	1.0	-0.8	-1.1	-0.6	-0.4	0.4	-0.5	-0.9	-0.8
Miserableness	0.7	1.2	3.6	-1.9	-0.7	-1.9	-0.1	0.4	-0.0	-1.7	-1.2	0.2	-1.2	0.9	-0.1
Eye problems/disorders: Glaucoma	0.7	0.9	2.0	-0.5	0.0	-0.5	1.2	-0.8	-1.4	1.4	-0.8	-1.2	0.9	-0.3	-1.0
Illnesses of father: High blood pressure	0.7	0.8	2.0	-0.9	-1.0	-0.9	1.4	-0.2	-0.7	-1.3	-0.3	0.5	-1.3	-0.6	-0.5
Basal cell carcinoma (self-reported)	0.7	0.9	2.6	-0.4	-0.9	-0.4	0.7	-1.6	-1.3	0.2	-0.9	0.3	-0.4	-1.5	-1.2
Leg fat mass (left)	0.7	2.6	6.6	-2.5	-1.0	-2.5	0.9	-1.6	-2.6	-1.3	0.2	0.6	-1.4	-0.0	-2.0
Neuroticism (Nagel 2018)	0.6	1.4	5.3	-2.3	-1.0	-2.3	0.3	0.8	-0.2	-1.8	-0.6	0.2	-0.7	0.7	-0.1
Lung FEV1/FVC ratio	0.6	2.9	11.1	-0.9	-1.0	-0.9	-1.3	1.0	0.2	-1.6	3.3	2.7	-2.3	1.6	0.8
Age when periods started (menarche)	0.6	1.5	3.6	1.7	0.3	1.7	0.9	1.2	1.2	0.3	1.9	1.1	-0.3	1.3	1.4
Medication: Levothyroxine sodium	0.6	1.0	3.0	-1.7	-0.6	-1.7	-0.8	-1.1	-0.9	-0.5	-0.4	-0.7	-0.6	-0.8	-1.3
Waist circumference	0.6	2.1	4.1	-2.0	-1.2	-2.0	1.4	-1.4	-1.9	-1.4	0.4	1.2	-1.3	0.3	-1.5
Alcohol usually taken with meals	0.6	0.9	1.8	-1.1	-0.8	-1.1	1.0	-1.2	-1.4	0.1	-0.5	0.4	0.1	-1.3	-1.2
Diabetes (self-reported)	0.6	0.9	3.0	-0.3	0.5	-0.3	0.6	-1.1	-0.9	1.3	-1.3	-1.0	0.5	-1.7	-1.0
Arm fat percentage (right)	0.6	2.4	5.0	0.1	2.2	0.1	1.0	-2.1	-1.9	2.2	-1.4	-1.6	1.2	-1.0	-1.7
Medication: Cholesterol lowering	0.6	1.0	4.0	0.4	1.0	0.4	0.0	-1.3	-0.9	2.0	-0.5	-1.4	0.6	-0.6	-0.9
Illnesses of mother	0.6	0.7	1.8	0.1	0.9	0.1	0.2	1.1	0.8	-1.2	1.3	1.1	0.4	1.1	0.8
Pulse wave Arterial Stiffness index	0.6	0.7	2.7	0.2	-0.0	0.2	1.4	-0.7	-0.7	1.4	-0.8	-0.3	0.3	-1.6	-0.5
Leg fat percentage (right)	0.6	2.2	7.4	-1.7	0.3	-1.7	1.3	-2.0	-2.7	0.6	-0.4	-1.0	-0.2	-1.0	-2.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	0.0	-0.6	0.0	0.8	-1.5	-0.4	0.7	-0.4	-1.0	1.2	-0.2	-1.2
Neck or shoulder pain in last month	0.6	0.9	1.9	-1.4	-1.3	-1.4	-0.2	0.1	-1.2	-0.7	-0.0	0.1	-0.7	-1.4	-0.4
Leg fat mass (right)	0.6	2.2	6.0	-2.3	-0.8	-2.3	0.9	-1.7	-2.4	-1.0	-0.0	0.2	-1.1	0.0	-1.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	-0.3	-0.8	-0.3	0.1	-1.1	-1.0	0.8	-1.2	-1.1	0.1	-1.1	-0.9
Hypertension (Self-reported)	0.6	1.7	6.2	-0.1	0.0	-0.1	1.9	-1.1	-0.2	-0.5	-1.0	-2.1	1.3	-2.5	-1.3
Medication for cholesterol	0.6	0.9	1.8	-1.3	-1.3	-1.3	-0.4	-0.4	-0.8	-1.3	-0.5	0.4	-0.5	1.3	-0.5
Breast cancer (self-reported)	0.6	0.7	1.4	-1.1	0.0	-1.1	-0.2	-0.8	-1.1	-0.9	-1.0	-0.3	1.0	-0.2	-1.2
Osteoarthritis (self-reported)	0.6	0.8	3.6	-0.9	-1.9	-0.9	-0.7	0.7	-0.8	0.4	0.8	0.1	-1.3	0.2	0.6
Ever taken oral contraceptive pill	0.6	0.6	2.5	0.6	0.7	0.6	1.4	-0.6	-0.8	1.6	-0.4	-0.1	-0.6	-0.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	3.6	1.0	1.1	1.0	0.6	0.1	0.4	1.9	0.3	-0.8	0.3	0.9	0.7
Leg fat percentage (left)	0.6	2.3	8.0	-1.8	0.3	-1.8	1.2	-2.0	-2.8	0.5	-0.2	-0.8	-0.4	-1.1	-2.2
Number of operations (self-reported)	0.6	0.9	2.2	-1.0	-0.6	-1.0	-0.6	-0.9	-1.5	0.7	-1.2	-0.7	0.2	-1.0	-1.1
Alcohol drinker status: Previous	0.6	0.7	4.2	0.1	0.9	0.1	0.7	-0.7	0.1	1.0	-0.6	-0.9	0.6	-2.0	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	0.8	-0.3	0.8	-0.7	0.8	0.9	1.2	1.3	0.2	-0.7	0.8	1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.3	-0.5	-1.2	-0.5	-0.1	-0.7	-0.5	-0.6	-1.3	-0.6	0.1	-1.5	-0.5
Supplements: Zinc	0.5	0.5	2.8	-0.2	-1.7	-0.2	0.8	-0.4	-0.4	0.2	-0.9	-0.4	0.7	-0.9	-0.4
Current tobacco smoking	0.5	0.8	2.6	0.5	-0.6	0.5	-0.2	1.4	1.1	-0.6	0.6	1.1	-1.0	0.3	1.6
Hair/balding pattern: Pattern 2	0.5	0.6	4.9	0.4	0.2	0.4	-2.2	0.5	0.9	-0.2	0.3	-0.3	0.8	-0.3	0.4
Qualifications: None of the above	0.5	1.1	4.9	0.3	0.9	0.3	2.2	-1.0	-0.8	1.3	-1.2	-0.3	0.0	-1.1	-1.0
Allergy	0.5	1.2	6.9	-0.5	-0.7	-0.5	2.6	-1.0	-0.5	-0.4	-1.4	-0.5	0.9	-1.4	-0.9
Medication: Ramipril	0.5	0.6	1.7	0.7	0.5	0.7	0.7	-0.6	0.3	1.1	-0.6	-1.3	1.2	0.1	-0.3
Fluid intelligence score	0.5	1.0	4.2	-1.6	-2.0	-1.6	-0.0	-0.8	-0.7	-0.4	-0.3	-0.3	-0.1	0.5	-0.9
Illnesses of siblings	0.5	0.8	2.9	0.7	1.7	0.7	-0.5	-0.5	0.4	1.7	-0.6	-0.7	1.0	0.2	-0.0
Hip circumference	0.5	2.1	4.0	-2.0	-1.1	-2.0	0.9	-1.1	-2.0	-1.4	1.2	1.1	-1.5	1.1	-1.3
Falls in the last year	0.5	0.7	5.0	0.4	0.4	0.4	0.6	-1.0	-0.5	2.2	0.0	-0.8	0.1	-1.0	-0.5
Prospective memory result	0.5	0.6	2.1	-0.1	0.9	-0.1	1.4	-0.8	-0.2	-0.0	-1.4	-0.4	0.9	-0.3	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	6.2	-0.7	-1.5	-0.7	2.3	-0.5	0.0	-2.5	0.9	0.9	-0.0	-0.2	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.2	-0.8	-0.3	-0.8	1.5	-0.7	-0.8	-0.6	-1.3	0.3	-0.0	-1.2	-0.6
Hair/balding pattern: Pattern 4	0.5	1.2	3.7	-1.1	-0.7	-1.1	-0.8	1.0	0.2	-0.6	0.9	1.1	-1.9	1.6	0.8
Medication: Amlodipine	0.5	0.7	2.3	1.1	0.4	1.1	-0.4	0.4	0.7	1.0	0.0	-1.4	1.5	0.4	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.5	3.1	0.1	0.5	0.1	-1.8	0.4	-0.1	0.9	-0.9	-0.9	0.4	0.4	0.0
Pulse rate, automated reading	0.5	1.6	5.3	-0.1	1.2	-0.1	0.6	-0.5	-0.7	1.2	-2.0	-2.3	1.2	-2.1	-0.5
Had major operations	0.5	0.6	2.3	-0.2	0.6	-0.2	-0.9	0.4	0.4	0.7	1.5	0.9	-0.7	1.3	0.4
Knee pain experienced in last month	0.5	0.8	4.4	-0.3	-1.1	-0.3	-2.1	-0.4	-0.8	1.3	-0.2	-0.5	-0.4	0.5	-0.4
Ever had bowel cancer screening	0.5	0.5	2.1	-0.5	-0.1	-0.5	0.4	-0.6	-1.5	1.1	-0.5	-0.1	-1.1	-0.6	-0.7
Back pain experienced in last month	0.5	0.7	2.1	1.0	1.4	1.0	-0.0	-0.8	-0.1	1.5	-0.5	-0.8	1.1	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.5	0.6	1.2	0.6	-1.0	0.8	0.6	0.5	1.1	0.4	-0.9	0.1	0.7
Medication: Blood pressure	0.5	1.0	3.9	0.5	0.4	0.5	0.8	-0.6	0.1	1.0	-0.3	-2.0	1.3	-1.7	-0.6
High cholesterol (Self-reported)	0.5	0.9	3.7	0.1	0.9	0.1	0.1	-1.4	-0.7	1.9	0.2	-0.3	-0.2	-1.6	-1.2
Average weekly beer plus cider intake	0.5	0.7	1.8	1.4	0.2	1.4	0.5	-0.6	0.4	1.1	-0.7	-0.6	0.8	-1.1	-0.0
Risk taking	0.5	0.7	2.6	-1.0	-1.6	-1.0	-0.6	-1.1	-0.9	0.0	-0.4	0.4	0.0	-0.3	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.3	0.9	0.9	0.9	-1.5	-0.1	0.4	1.0	-0.6	0.2	0.5	-0.9	0.1
Bipolar Disorder (2018)	0.4	0.6	2.7	1.6	0.6	1.6	1.2	-0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.4	0.6	4.1	0.0	0.0	0.0	-1.7	2.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2017)	0.4	0.9	3.4	-0.0	-0.4	-0.0	-0.1	1.4	1.0	-1.0	0.8	-0.1	-0.9	1.8	1.4
Irritable Bowel Disease (IBD)	0.4	1.0	3.0	-0.2	-0.9	-0.2	-0.1	1.6	0.8	-1.7	0.8	0.5	-0.8	1.2	1.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	3.0	-1.6	-1.7	-1.6	0.2	-0.5	-0.6	-0.9	-0.5	-0.5	0.1	0.4	-0.8
Fasting Glucose	0.4	0.4	1.6	0.2	1.1	0.2	1.2	-0.0	-0.2	1.2	-0.3	-0.2	0.6	0.5	0.1
Blood White Count	0.4	2.7	7.7	-1.7	-2.2	-1.7	2.8	-1.1	-1.3	-1.3	-1.1	-0.9	-0.6	-2.3	-1.4
Waist Hip Ratio (WHR)	0.4	1.7	5.7	-0.6	-1.6	-0.6	1.4	0.8	0.7	-2.0	0.4	2.4	-1.8	-0.2	0.8
Number of treatments/medications taken	0.4	0.7	1.6	-0.1	0.8	-0.1	-0.1	-1.0	-0.5	1.1	-0.7	-1.2	0.9	-1.3	-0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	-0.0	-0.4	-0.0	-1.3	1.1	0.2	0.3	-0.2	0.6	-0.8	-1.1	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	2.1	-0.8	-0.9	-0.8	-0.7	0.4	-0.2	-0.1	0.4	0.2	-1.5	-0.4	0.3
Vitamin and mineral supplements	0.4	0.6	3.4	-0.7	-0.2	-0.7	0.3	0.0	-0.6	0.5	0.8	0.3	-1.9	-0.8	0.0
Severe depression (siblings)	0.4	0.5	1.6	-0.0	-1.3	-0.0	0.1	0.1	-0.6	-0.8	0.2	1.1	-1.1	0.7	-0.1
Trunk fat percentage	0.4	1.5	3.8	-0.4	1.6	-0.4	2.0	-1.8	-1.8	1.4	-0.2	-0.5	0.3	-0.6	-1.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.6	-0.6	-0.2	-0.6	-0.5	0.5	0.0	-0.1	1.3	0.8	-1.2	0.1	0.1
High blood pressure	0.4	1.1	4.1	-0.0	0.2	-0.0	1.5	-0.6	0.2	-0.4	-1.1	-2.0	1.0	-1.9	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	-0.2	-0.6	-0.2	-0.6	-0.7	-0.9	1.1	0.3	-0.7	-0.5	-0.9	-0.6
Mouth/teeth dental problems	0.4	0.5	2.4	0.5	0.1	0.5	-0.2	-0.2	1.1	-1.1	-0.9	-0.4	1.6	-0.2	-0.3
Medication: Simvastatin	0.4	0.6	2.0	0.1	0.6	0.1	0.7	-0.9	-0.9	1.4	1.0	0.8	-0.8	-0.1	-0.8
Pulse rate	0.4	0.7	2.8	0.7	0.8	0.7	0.7	0.2	-0.1	1.1	-0.3	-0.8	0.9	-1.7	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.2	-0.6	-1.8	-0.6	-0.9	0.9	0.0	-1.2	1.1	0.7	-1.3	0.2	0.6
Depression (self-reported)	0.4	0.5	2.3	-0.7	1.0	-0.7	1.5	0.0	-0.3	-0.2	-1.1	-0.5	0.1	-0.2	0.1
Lung cancer (father)	0.4	0.4	2.4	0.5	0.6	0.5	-1.6	0.1	0.6	0.1	0.6	0.2	0.9	0.2	0.0
Birth weight	0.4	0.9	3.1	0.1	-0.5	0.1	0.9	0.3	1.0	-1.7	-0.4	1.8	-0.3	1.4	0.6
Forced vital capacity (FVC), Best measure	0.4	1.5	6.9	-0.2	-1.4	-0.2	2.3	0.2	0.9	-2.6	0.8	1.2	0.3	0.3	0.2
Body fat percentage	0.4	1.7	4.4	-0.6	1.6	-0.6	1.6	-1.9	-2.1	1.5	-0.5	-0.8	0.3	-0.8	-1.7
Qualifications: College or University degree	0.4	1.2	4.7	-1.5	-2.2	-1.5	-1.3	0.1	-0.9	-1.5	-0.6	-0.5	-0.2	0.2	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.6	3.5	0.8	-0.1	0.8	1.9	0.1	1.2	-0.6	-0.3	-0.6	0.1	0.6	0.4
Angina (self-reported)	0.4	0.5	2.2	0.2	-0.3	0.2	1.0	-0.5	-0.8	1.5	0.3	-0.8	-0.7	-0.9	-0.3
Whole body fat mass	0.4	1.5	4.5	-1.6	-0.1	-1.6	1.2	-1.6	-2.1	-0.5	0.1	0.4	-0.8	0.2	-1.6
Alcohol intake frequency.	0.4	0.9	2.7	-0.2	1.0	-0.2	1.2	1.6	0.7	-0.8	0.7	1.0	-1.1	0.1	1.2
Age at last live birth	0.4	0.6	1.5	0.3	-0.9	0.3	0.5	-0.7	-1.1	0.2	-0.3	-1.0	1.2	-0.6	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.1	-0.1	-0.2	-0.1	-1.4	0.8	0.2	0.0	0.1	1.0	-1.1	-0.3	0.6
Smoking status: Previous	0.4	0.6	3.1	-0.8	-0.4	-0.8	0.6	-0.1	-0.1	-1.8	-0.0	1.6	-0.2	0.1	-0.4
Mood swings	0.4	0.7	1.9	-1.3	-0.9	-1.3	0.1	0.4	0.1	-1.4	-0.7	-0.8	-0.3	0.6	-0.0
Eye problems/disorders: Cataract	0.4	0.4	1.4	-0.9	-1.2	-0.9	-0.2	0.9	-0.4	-0.1	0.4	0.5	-0.7	-0.3	0.4
Smoking status: Current	0.4	0.6	2.0	0.8	-0.7	0.8	-0.3	1.0	1.2	-0.5	0.1	0.6	-0.5	0.2	1.4
Wears glasses or contact lenses	0.4	0.4	3.3	0.1	0.9	0.1	0.7	0.1	-0.7	1.8	-0.4	-0.4	-0.1	-0.1	0.1
Medication: Bendroflumethiazide	0.4	0.6	2.2	0.9	1.5	0.9	0.5	-0.1	0.3	-0.3	0.3	-0.2	1.1	-1.0	-0.1
Pack years of smoking	0.4	0.6	1.7	-0.1	-0.5	-0.1	1.1	-0.7	-0.7	0.1	-1.3	-1.1	1.0	-0.9	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	4.0	2.0	0.4	2.0	1.0	-1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.3	0.4	1.0	-0.2	0.8	-0.2	-0.7	0.6	0.7	-0.8	-0.7	0.3	0.5	1.0	0.2
Triglycerides	0.3	0.5	1.7	-0.5	0.2	-0.5	-1.3	0.1	-1.0	1.1	-0.1	0.5	-0.8	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	1.1	0.0	1.1	0.5	0.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.3	3.0	14.7	0.9	1.0	0.9	0.6	-2.1	-1.1	3.8	0.2	-2.7	1.7	-0.5	-1.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	-0.9	-0.7	-0.9	0.6	-0.4	-0.7	-0.1	-1.2	-0.7	-0.3	-0.7	-0.7
Sensitivity / hurt feelings	0.3	0.6	1.9	-1.4	0.5	-1.4	-0.3	0.0	-0.4	-1.2	-0.6	0.5	0.0	0.4	-0.6
Angina	0.3	0.4	1.4	0.1	-0.2	0.1	0.7	-0.3	-0.7	1.2	0.6	-0.5	-0.9	-0.7	-0.2
Diabetes (mother)	0.3	0.4	1.7	0.7	0.9	0.7	-0.4	-0.2	0.4	1.3	-0.8	-0.6	0.5	0.4	0.2
Pack years adult smoking proportion	0.3	0.5	1.9	-0.1	-0.6	-0.1	0.5	-0.6	-0.3	-0.4	-1.4	-0.9	1.1	-0.7	-0.3
Fed-up feelings	0.3	0.6	1.5	-0.6	-0.3	-0.6	-1.0	0.9	1.0	-1.1	-1.2	-0.5	-0.3	0.6	0.7
Body mass index (BMI)	0.3	1.4	4.7	-1.5	-0.1	-1.5	-0.2	-1.6	-2.2	0.3	-0.6	-0.7	-0.3	-0.1	-1.7
Impedance of leg (left)	0.3	1.2	5.1	1.2	1.3	1.2	2.3	0.8	0.8	0.2	1.2	0.5	0.6	-1.0	0.8
Trunk fat mass	0.3	1.5	3.9	-1.5	-0.1	-1.5	1.6	-1.5	-2.0	-0.5	0.4	0.8	-0.9	0.3	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.7	0.4	1.6	0.4	-0.1	0.1	0.0	1.3	-0.3	-0.4	-0.0	1.5	0.1
Financial difficulties in last 2 years	0.3	0.4	2.2	0.0	1.2	0.0	-0.5	-0.5	0.1	0.0	-0.5	-0.6	1.5	0.2	-0.3
Worrier / anxious feelings	0.3	0.6	1.5	-0.7	-0.4	-0.7	0.1	1.1	0.2	-1.1	1.2	0.6	-0.9	-0.0	0.6
Hair/balding pattern: Pattern 3	0.3	0.5	2.5	-0.2	0.2	-0.2	0.9	0.2	0.4	-1.6	-0.1	1.1	0.3	0.9	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.5	-0.2	-0.0	-0.2	1.2	0.4	0.0	-1.0	-0.1	0.5	-0.4	-0.4	0.3
Asthma	0.3	0.7	4.0	0.1	0.3	0.1	-2.0	0.8	0.3	-0.1	0.6	0.7	-0.8	1.1	0.6
Arm fat mass (right)	0.3	1.1	3.8	-1.3	-0.0	-1.3	0.7	-1.7	-1.9	-0.1	-0.5	0.1	-0.3	0.2	-1.6
Exposure to tobacco smoke at home	0.3	0.4	1.1	-0.5	-0.8	-0.5	0.2	0.1	-0.5	-0.8	0.1	0.5	-0.8	1.1	0.3
Tense / ‘highly strung’	0.3	0.5	1.5	-1.2	-0.4	-1.2	-0.5	0.6	0.0	-1.2	-0.4	0.2	0.0	0.1	0.1
High blood pressure (siblings)	0.3	0.4	2.1	0.4	-1.0	0.4	-0.6	0.5	0.5	-1.5	-0.2	0.5	-0.0	0.2	0.2
Age at first live birth	0.3	0.5	1.9	0.8	-0.4	0.8	-0.8	0.9	0.3	0.1	1.4	0.4	-0.0	0.8	0.7
Eye problems/disorders: None of the above	0.3	0.4	1.2	1.0	0.8	1.0	-1.1	-0.1	0.9	-0.1	0.1	-0.3	0.2	-0.5	0.1
Medication: Omeprazole	0.3	0.4	1.9	0.5	0.5	0.5	-1.4	0.0	0.4	0.2	0.1	0.6	-0.3	-0.9	0.2
Friendships satisfaction	0.3	0.4	2.1	-0.7	-0.7	-0.7	-0.0	-0.3	-0.2	-1.4	-0.3	-0.4	0.2	0.6	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	-0.0	0.1	-0.0	1.1	0.9	0.1	-0.1	1.0	0.0	-0.9	0.7	0.9
Asthma (self-reported)	0.3	0.7	3.6	-0.1	0.2	-0.1	-1.9	0.9	0.3	-0.2	0.7	0.9	-0.9	1.1	0.6
Arm fat mass (left)	0.3	1.4	4.6	-1.5	-0.1	-1.5	0.7	-1.8	-2.1	-0.1	-0.6	-0.3	-0.4	0.1	-1.8
Medication: Paracetamol	0.3	0.5	2.8	-0.2	1.0	-0.2	0.2	-0.1	-0.9	0.8	-0.8	-0.3	1.7	-0.2	-0.1
Medication: Lisinopril	0.3	0.3	1.2	0.7	0.6	0.7	-0.0	0.3	1.1	-0.1	-0.4	-0.9	0.6	-0.2	0.4
Ever smoked	0.3	0.5	2.4	0.2	-0.6	0.2	0.5	0.2	1.0	-1.6	-0.1	1.2	0.0	-0.1	0.4
Myopia	0.3	0.4	1.4	-0.5	-0.4	-0.5	-0.6	0.6	0.6	-1.2	0.1	0.1	-0.3	1.2	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.8	-0.1	-0.2	-0.1	-1.6	0.7	0.0	0.0	0.7	2.0	-0.6	1.7	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.2	-0.4	0.4	-0.4	-0.8	-0.4	-0.5	1.1	0.8	-0.1	-0.7	-0.1	-0.3
Schizophrenia (2018)	0.2	0.3	1.5	1.2	0.1	1.2	0.3	-0.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.2	0.4	1.7	-0.1	-0.8	-0.1	-0.2	1.1	0.4	-1.3	0.3	0.7	-0.2	0.1	0.8
Schizophrenia (2014)	0.2	0.4	2.4	1.6	0.0	1.6	-0.3	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.2	1.3	2.9	-1.7	-0.9	-1.7	-1.4	-0.8	-1.7	-0.6	0.5	0.3	-1.2	0.2	-1.0
Smoking Status	0.2	0.5	1.5	-0.2	-1.0	-0.2	0.6	0.4	0.7	-1.2	-0.5	0.9	-0.4	0.2	0.7
Relative age of first facial hair	0.2	0.4	1.2	-0.6	-1.1	-0.6	-0.9	-0.8	-0.3	0.1	-0.8	0.2	-0.3	-0.2	-0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	-0.6	-0.9	-0.6	-0.4	0.3	0.1	-0.4	0.5	0.3	-0.5	-0.2	0.2
Impedance of leg (right)	0.2	1.1	5.2	1.2	1.2	1.2	2.3	0.5	0.8	0.3	0.8	0.0	0.8	-1.0	0.7
Stomach or abdominal pain in last month	0.2	0.3	1.1	0.4	0.0	0.4	0.7	-0.1	-0.4	0.8	0.5	-0.7	-0.3	-1.0	-0.0
Past tobacco smoking	0.2	0.4	2.2	-0.3	0.1	-0.3	-0.3	-0.1	-0.7	1.3	0.3	-1.5	-0.1	-0.1	-0.3
Heart attack	0.2	0.3	1.1	-0.4	0.4	-0.4	-0.7	-0.3	-0.5	1.0	0.7	-0.1	-0.7	-0.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.4	0.0	1.0	0.0	-0.5	-0.4	-0.4	1.2	0.3	0.0	-0.8	0.4	-0.2
Father’s age at death	0.2	0.2	1.4	0.0	-0.0	0.0	0.4	-0.2	-0.4	1.2	0.5	0.0	-0.7	0.3	0.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.0	-0.0	-0.0	-0.0	-0.0	-0.0	0.4	-0.3	-0.6	-1.0	0.8	0.9	-0.1
Medication: Paracetamol	0.2	0.4	1.8	-0.7	0.6	-0.7	-0.3	0.2	-1.4	0.6	-0.4	-0.1	0.9	-0.3	-0.1
Headache pain in last month	0.2	0.4	1.8	0.1	1.3	0.1	-0.7	0.6	0.4	-0.6	0.6	0.2	0.3	0.6	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	0.3	-0.0	0.3	-0.6	-0.3	0.8	0.3	-0.7	-0.3	0.4	0.8	-0.0
Overall health rating	0.2	0.5	1.2	-0.9	-0.1	-0.9	-0.6	-0.7	-1.1	0.8	0.2	-0.8	-1.0	-0.2	-0.7
Medication: Aspirin	0.2	0.3	0.9	-0.3	0.9	-0.3	-0.6	-0.6	-0.6	0.9	-0.0	-0.4	-0.1	-0.2	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.6	0.0	-0.6	-0.2	-0.2	-0.6	-0.5	-0.2	0.2	-0.3	-0.7	-0.4
Medication: Aspirin	0.2	0.2	1.1	0.1	0.6	0.1	-0.5	-0.5	-0.3	1.1	-0.1	-0.3	-0.0	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.8	-0.5	-0.6	-0.5	0.5	0.5	-0.3	-0.7	1.4	0.8	-0.2	0.1	0.2
Guilty feelings	0.2	0.3	1.3	-0.2	0.2	-0.2	1.1	1.1	0.0	-0.3	0.8	0.0	-0.4	0.7	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.5	0.2	-0.5	-0.6	-0.4	-0.5	-0.7	-0.1	0.7	-0.2	0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.4	-0.7	-0.8	-0.7	0.2	0.4	-0.4	-0.2	1.2	0.4	-1.0	0.5	-0.0
Crohns Disease (2012)	0.1	0.2	1.3	0.3	0.1	0.3	1.1	1.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.1	0.2	0.9	-0.1	0.0	-0.1	-0.9	-0.1	0.2	-0.6	-0.9	-0.8	0.1	0.3	-0.2
Ulcerative Colitis	0.1	0.1	0.5	0.7	0.0	0.7	0.2	0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.1	0.6	2.7	-0.8	0.4	-0.8	-1.6	0.6	-0.1	-1.0	0.5	0.5	-0.2	-0.9	0.3
Blood Red Count	0.1	1.4	4.2	0.2	0.3	0.2	0.0	1.7	1.5	-1.8	2.1	1.1	-0.9	-0.7	1.1
Respiratory disease	0.1	0.2	0.6	-0.2	-0.4	-0.2	-0.7	-0.1	-0.4	0.8	-0.5	-0.3	-0.3	-0.0	-0.2
Tanning	0.1	0.6	4.0	0.9	-0.1	0.9	0.3	0.1	0.1	2.0	0.4	0.5	-0.7	0.8	0.5
Medication: Metformin	0.1	0.2	1.2	-0.2	0.2	-0.2	-0.3	-0.0	-0.5	1.1	-0.0	-0.2	-0.5	-0.6	0.1
Maternal smoking around birth	0.1	0.2	0.6	-0.1	0.2	-0.1	-0.8	0.5	-0.2	-0.8	-0.4	0.3	-0.4	-0.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.1	-0.3	-0.1	0.1	0.0	0.2	-0.5	-0.1	-0.4	0.1	-0.5	-0.1
Breastfed as a baby	0.1	0.1	0.6	0.1	-0.4	0.1	-0.1	-0.3	0.3	0.1	0.0	-0.1	0.6	-0.8	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	1.1	-0.0	0.5	-0.0	-0.1	0.3	0.0	-0.2	0.2	1.0	-0.8	-0.2	0.4
Medication: Gliclazide	0.1	0.2	0.7	-0.2	0.2	-0.2	-0.1	0.4	-0.2	0.1	0.6	0.8	-0.2	0.8	0.1
Pain experienced in last month	0.1	0.2	0.6	0.6	0.5	0.6	0.2	0.0	0.8	0.1	0.7	0.3	0.4	-0.3	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.4	-0.2	0.0	-0.2	-0.6	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.4	11.4	0.8	-0.3	0.8	-3.4	-0.5	0.7	0.3	0.0	-1.3	1.0	-0.8	-0.2
Relative age voice broke	0.0	0.1	0.3	0.3	0.0	0.3	0.1	-0.3	0.1	0.6	0.1	0.1	-0.2	-0.1	0.2

Hub : Genes

RPS2

Models

Trait associations