Hub : Genes

UBE2I

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0510	0.0220	1.0e-02	0.053	0.006	0.032	0.019	0.038	4.9e-07	5.8e-02	7.2e-05	1.9e-03	1.7e-05
2	GTEx	Artery Tibial	0.1271	0.0357	1.2e-05	0.152	NA	0.139	NA	0.147	6.2e-12	NA	4.8e-11	NA	1.4e-11
3	GTEx	Esophagus Muscularis	0.2050	0.0560	2.1e-05	0.101	NA	0.088	NA	0.075	1.1e-06	NA	5.1e-06	NA	2.7e-05
4	YFS	Blood	0.0860	0.0186	2.0e-10	0.038	0.033	0.040	0.037	0.046	1.2e-12	5.0e-11	4.4e-13	2.8e-12	9.8e-15
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0205	0.0113	6.1e-03	0.029	0.014	0.015	NA	0.018	2.6e-04	8.3e-03	7.0e-03	NA	3.4e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0349	0.0190	5.3e-03	0.004	0.018	0.010	NA	0.007	1.0e-01	3.7e-03	2.4e-02	NA	5.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	1.2	0.6	0.1	-0.0	-1.1	0.0	0.8
Bipolar Disorder or Schizophrenia	1.1	2.7	5.6	1.4	1.5	1.5	-2.4	-1.5	1.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.5	0.4	0.6	-0.5	-0.5	0.4
Depression (Nagel 2018)	0.1	0.2	0.9	0.2	-0.1	0.2	0.2	-0.3	0.9
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.6	-0.6	-1.0	-1.5	-0.0	0.9	-2.6
Neuroticism (Nagel 2018)	0.2	0.4	1.1	-1.0	-0.7	-0.5	-0.1	0.8	-0.0
Schizophrenia (2018)	1.4	3.0	4.7	1.4	1.7	1.9	-2.2	-2.0	0.9
Schizophrenia vs Biploar Disorder	1.2	1.6	3.7	1.5	1.9	1.7	-0.8	0.0	0.0
Worry (Nagel 2018)	0.7	1.5	2.3	-1.4	-1.5	-1.2	1.1	1.5	0.1
Alzheimer’s Disease (in mother)	1.8	2.1	3.1	1.4	1.8	1.4	-0.9	-1.7	1.4
Alzheimer’s Disease (in father)	1.1	1.1	2.3	1.1	1.4	1.1	-0.4	-1.5	-0.2
Alzheimer’s Disease (including proxy)	2.5	3.7	7.2	1.9	2.7	2.0	-0.8	-2.5	0.6
Crohns Disease (2017)	0.1	0.2	0.5	0.4	0.4	0.2	-0.3	-0.4	-0.7
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	0.5	0.4	0.5	-0.7	-0.4	-0.4
Ulcerative Colitis (UC)	0.0	0.1	0.4	0.0	-0.0	0.3	-0.6	0.0	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.1	2.1	3.4	-1.7	-1.7	-1.9	0.3	1.6	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.7	0.0	-0.6	-0.6	-0.3	0.2	-2.2
Breast Cancer	2.1	5.1	7.1	2.3	2.5	2.4	-2.0	-2.7	1.6
Ovarian Cancer	0.4	0.6	2.8	0.3	0.4	0.0	0.6	-0.3	-1.7
Prostate Cancer	0.1	0.1	0.6	0.1	-0.2	-0.2	0.8	0.3	-0.2
Age at First Birth	1.3	1.9	2.6	-1.6	-1.5	-1.4	0.9	1.5	-1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.7	0.1	0.4	0.4	-0.3	-0.2	1.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.4	0.6	2.0	-0.4	-0.7	-0.4	1.4	0.6	-0.6
Mean Putamen Volume	1.5	1.7	2.6	1.2	1.6	1.4	-1.2	-1.5	0.8
Fasting Glucose	1.7	2.0	2.7	-1.5	-1.2	-1.2	1.6	1.5	-1.6
HbA1C	0.2	0.2	0.6	-0.8	-0.3	0.1	0.3	0.5	0.1
HDL Cholesterol	0.4	0.6	2.2	0.1	0.0	-0.4	1.1	-0.0	-1.5
LDL Cholesterol	0.3	0.4	2.0	0.4	0.3	0.2	-1.4	-0.1	0.4
Lupus	1.1	1.7	2.0	1.3	1.4	1.1	-1.1	-1.4	1.4
Neuroticism (2016)	0.2	0.3	0.4	-0.6	-0.6	-0.5	0.4	0.5	-0.6
Primary Biliary Cirrhosis	0.7	0.9	3.6	0.7	0.3	0.8	-0.9	-0.2	1.9
Rheumatoid Arthritis	0.3	0.5	0.9	-0.7	-0.7	-0.5	-0.5	1.0	0.6
Schizophrenia (2014)	1.4	3.1	3.9	1.7	1.8	1.8	-1.9	-2.0	1.4
Triglycerides	1.0	1.7	3.8	1.0	0.8	1.1	-1.6	-0.8	1.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	2.0	0.0	0.0	0.0	1.4	0.0	0.0
Ulcerative Colitis	0.9	1.3	1.9	-1.1	-1.4	-1.3	0.9	1.2	-0.8
Blood Eosinophil Count	0.1	0.5	3.0	-0.3	0.1	-0.3	0.2	0.2	1.7
Blood Platelet Count	0.1	1.0	5.7	0.0	0.4	-0.1	2.4	-0.6	0.0
Blood Red Count	0.7	6.5	10.3	2.0	2.4	2.7	-3.2	-2.3	2.5
Blood White Count	0.8	5.6	17.3	0.4	0.3	-0.9	3.9	-0.6	-4.2
Heel T-Score	0.0	0.2	0.7	-0.0	-0.1	-0.9	-0.2	0.1	-0.8
BMI	0.1	0.4	1.9	-0.5	0.0	0.7	-1.4	-0.0	0.3
Height	0.3	5.8	12.0	-2.3	-2.4	-2.1	1.6	2.3	-3.5
Waist Hip Ratio (WHR)	0.2	0.7	1.1	0.8	0.9	0.3	0.7	-1.0	-1.0
Systolic Blood Pressure	7.3	36.5	45.7	-6.0	-6.1	-6.8	6.5	6.0	-4.7
Smoking Status	1.1	2.7	4.4	2.1	1.8	1.8	-0.4	-1.9	1.3
Allergy or Eczema	0.2	0.4	1.1	0.9	0.1	0.2	-0.6	-0.1	1.1
Cardiovascular Disease	4.2	13.8	19.8	-3.5	-3.6	-4.0	4.5	3.4	-3.2
Hypothyroidism (self reported)	1.0	2.2	3.7	-0.6	-1.6	-1.7	1.4	1.4	-1.9
Respiratory disease	0.0	0.1	0.5	-0.0	-0.1	0.0	-0.7	0.2	-0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	0.6	0.3	-0.0	0.2	-0.2	-0.1
Lung FEV1/FVC ratio	0.2	0.9	3.4	0.7	0.8	0.3	1.9	-0.8	-0.6
Lung FVC	0.2	1.0	1.4	1.1	1.2	1.0	-0.6	-1.1	-0.8
Neuroticism	0.1	0.1	0.4	-0.2	-0.4	-0.0	0.7	0.2	-0.3
Chronotype (morning person)	0.5	1.1	2.5	-0.7	-1.0	-1.6	1.3	0.9	-0.2
Hair Pigment	0.1	4.1	8.0	-2.7	-2.4	-1.7	-0.8	2.8	0.3
Tanning	0.3	3.8	5.9	1.9	2.4	1.9	0.1	-2.1	2.4
Hand grip strength (left)	0.4	1.1	2.3	-1.5	-0.8	-0.9	1.2	0.9	-0.7
Number of treatments/medications taken	0.2	0.4	0.9	0.9	0.5	0.1	0.8	-0.7	-0.2
Average weekly spirits intake	1.3	1.6	2.8	1.0	1.5	1.7	-0.5	-1.5	1.2
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.3	0.3	-0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.1	-0.3	-0.1	0.6	-0.1	-0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.5	0.5	0.5	0.3	-0.7	-0.4	-0.1
Relative age of first facial hair	1.5	3.2	3.6	-1.8	-1.7	-1.9	1.8	1.8	-1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.0	0.3	0.0	0.2	-0.5	-0.0	1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.7	2.7	1.6	1.2	1.4	-1.5	-1.3	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	3.5	-0.2	0.0	-0.1	-0.1	-0.1	-1.9
Systolic blood pressure, automated reading	5.7	16.5	20.1	-4.2	-4.2	-4.5	4.4	4.1	-2.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.4	1.0	1.2	0.9	-1.1	-1.0	0.3
Angina	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.3	-0.1	0.1
Medication for hormone replacement therapy	1.7	1.9	4.0	2.0	1.3	1.5	-0.9	-1.3	1.1
Vitamin and mineral supplements	0.2	0.2	0.8	-0.3	0.4	0.4	-0.9	-0.2	0.4
Supplements: Zinc	0.1	0.1	0.4	0.1	0.0	-0.0	0.7	-0.0	0.5
Medication: Co-codamol	8.6	10.0	11.6	3.1	3.4	3.4	-2.8	-3.4	2.8
Medication: Metformin	0.2	0.2	0.3	0.5	0.5	0.6	-0.5	-0.3	-0.4
Diabetes (father)	0.6	0.7	1.2	0.6	1.1	1.0	-0.4	-1.1	-0.4
Diabetes (mother)	1.6	2.1	4.0	-0.3	-0.8	-1.8	2.0	0.9	-1.9
Severe depression (siblings)	0.2	0.2	0.4	0.4	0.5	0.6	-0.5	-0.5	0.4
Pack years adult smoking proportion	0.2	0.3	0.6	-0.0	0.7	0.7	-0.2	-0.8	0.6
Impedance of leg (right)	2.4	11.6	18.0	3.3	3.8	3.4	-1.3	-3.6	4.2
Leg fat-free mass (left)	0.6	3.3	5.4	-2.3	-2.2	-1.3	-0.6	2.1	-1.8
Trunk fat percentage	2.0	8.0	15.7	1.2	1.9	3.1	-3.8	-1.8	4.0
Hand grip strength (right)	0.6	1.7	2.7	-1.7	-1.1	-1.3	1.6	1.3	-0.6
Townsend deprivation index at recruitment	3.5	5.0	7.1	2.1	2.4	2.7	-1.4	-2.5	2.1
Current tobacco smoking	1.4	2.2	3.6	1.9	1.8	1.5	-0.3	-1.9	0.7
Average weekly fortified wine intake	1.2	1.4	3.1	0.6	1.0	1.1	-1.8	-0.8	1.5
Maternal smoking around birth	0.1	0.2	0.4	0.1	0.4	0.5	-0.1	-0.3	0.6
Fed-up feelings	0.0	0.0	0.1	0.0	0.1	0.3	0.2	-0.2	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	-0.3	-0.2	-0.2	0.7	0.1	0.1
Relative age voice broke	1.5	2.3	3.2	-1.0	-1.6	-1.7	1.8	1.3	-1.6
Taking other prescription medications	1.3	2.0	2.9	1.5	1.5	1.3	-0.7	-1.5	1.7
Age when periods started (menarche)	1.3	3.1	6.6	0.7	1.9	1.9	-0.9	-1.7	2.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.7	0.9	0.9	-0.2	-1.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	1.0	0.5	0.3	-0.3	-0.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.6	-1.1	-1.0	-1.0	0.5	1.3	0.1
Qualifications: CSEs or equivalent	2.0	2.6	7.0	1.5	1.1	1.6	-2.7	-0.9	1.4
Serious illness, injury or assault to yourself	1.7	2.0	3.5	1.9	1.2	1.5	-0.7	-1.2	1.7
High blood pressure	3.1	8.8	15.4	-2.6	-2.6	-2.8	3.9	2.3	-3.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.6	0.5	-0.1	-0.1	0.1	0.2	0.8
Multivitamins +/- minerals	0.9	1.2	2.0	-0.7	-1.4	-1.1	0.8	1.4	-0.9
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.8	-0.5	-0.7	1.2	0.6	-0.7
Supplements: Glucosamine	1.6	2.1	3.6	1.8	1.0	1.2	-1.4	-1.2	1.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.5	0.1	-0.0	-0.2	0.7	-0.0	-0.1
Medication: Atenolol	0.9	1.1	2.2	-1.0	-0.9	-1.4	1.5	0.6	-0.7
Medication: Levothyroxine sodium	0.1	0.2	0.9	0.2	-0.0	-0.2	0.5	-0.2	-0.9
Sitting height	0.3	2.1	3.7	-1.8	-1.6	-1.4	0.7	1.9	-0.9
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	0.5	0.7	1.4	-0.6	-0.5	1.3
High blood pressure (mother)	1.5	2.1	3.4	-1.5	-1.5	-1.8	1.5	1.3	-0.9
Body mass index (BMI)	0.3	1.3	5.0	-0.3	0.1	1.2	-2.2	-0.2	1.0
Impedance of leg (left)	2.0	9.6	18.1	3.0	3.3	3.0	-0.9	-3.1	4.3
Leg predicted mass (left)	0.6	3.3	5.2	-2.3	-2.2	-1.3	-0.5	2.1	-1.9
Trunk fat mass	1.0	4.2	9.9	0.5	1.1	2.3	-3.1	-1.0	2.7
Waist circumference	0.2	0.9	3.4	-0.3	0.3	1.1	-1.9	-0.4	0.6
Number of incorrect matches in round	2.6	4.4	10.4	-1.2	-1.8	-2.0	3.2	1.5	-2.2
Past tobacco smoking	0.3	0.5	0.8	-0.9	-0.7	-0.7	-0.3	0.8	-0.7
Alcohol usually taken with meals	2.2	3.6	5.2	-1.8	-2.0	-2.3	1.2	2.2	-1.6
Nervous feelings	0.0	0.1	0.3	0.0	0.1	0.1	0.3	0.1	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.2	-0.2	-0.2	0.3	0.0	0.3
Hearing difficulty/problems with background noise	1.0	1.7	3.3	1.8	1.3	1.2	-1.0	-1.6	-0.0
Hair/balding pattern: Pattern 2	0.9	1.1	2.5	1.6	1.0	0.9	-0.9	-1.1	-0.5
Had menopause	0.7	0.9	1.4	-0.5	-0.9	-1.1	1.2	0.8	-0.9
Had other major operations	0.2	0.3	0.8	0.5	-0.0	-0.3	0.9	-0.2	-0.7
Forced vital capacity (FVC)	0.1	0.3	1.0	0.2	0.3	0.7	-1.0	-0.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.0	1.2	0.9	0.7	-1.4	-0.8	0.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.3	0.8	1.1	0.9	-0.2	-1.1	0.1
Qualifications: None of the above	4.8	10.3	13.0	3.2	3.6	3.6	-1.9	-3.5	3.1
Financial difficulties in last 2 years	0.6	0.8	1.5	0.7	0.9	1.2	-0.7	-1.2	-0.1
Mouth/teeth dental problems	0.2	0.3	0.6	-0.8	-0.5	-0.6	0.5	0.6	0.3
Heart attack	0.0	0.1	0.2	0.0	0.5	-0.0	-0.1	-0.3	-0.1
Allergy	0.1	0.2	0.5	-0.5	0.0	-0.2	0.4	-0.1	-0.7
Pain all over the body in last month	0.4	0.4	1.3	0.0	-0.6	-0.6	1.1	0.6	0.6
Diabetes (self-reported)	0.1	0.1	0.3	0.3	0.3	0.2	-0.1	-0.2	-0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	-0.4	-0.5	-1.1	0.9	0.5	-0.3
Medication: Ramipril	2.0	2.6	4.0	-1.8	-1.5	-2.0	1.4	1.6	-1.1
Medication: Simvastatin	1.8	2.6	3.9	-2.0	-1.8	-1.5	0.9	1.7	-1.6
Fluid intelligence score	1.9	3.9	5.9	-1.7	-2.3	-2.2	0.9	1.9	-2.4
Illnesses of siblings	1.0	1.3	2.4	-0.6	-1.5	-1.3	1.0	1.5	-0.5
Neuroticism score	0.2	0.5	0.8	-0.8	-0.7	-0.5	0.9	0.7	-0.7
Weight	0.2	0.8	2.9	-1.0	-0.6	0.5	-1.7	0.6	0.2
Impedance of arm (right)	0.5	2.2	7.3	0.7	1.1	0.9	-1.5	-1.0	2.7
Arm fat percentage (right)	1.0	3.8	10.8	0.5	1.0	1.9	-3.3	-1.0	2.4
Trunk fat-free mass	0.7	4.1	9.2	-1.9	-2.1	-1.6	1.2	2.0	-3.0
Hip circumference	0.4	1.7	6.4	-0.4	0.1	1.4	-2.5	-0.1	1.4
Time employed in main current job	0.7	0.8	1.1	-0.6	-1.0	-0.8	0.8	0.9	-1.1
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.4	0.5	0.6	0.2	-0.4	0.5
Father’s age at death	0.0	0.1	0.2	0.2	0.1	0.3	-0.1	-0.1	0.4
Worrier / anxious feelings	2.7	5.1	9.8	-3.1	-2.7	-2.2	0.6	2.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.8	0.5	0.5	0.5	-0.7	-0.2
Falls in the last year	0.1	0.2	0.4	0.2	-0.0	0.6	-0.7	-0.3	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.4	0.6	0.7	-0.4	-0.4	0.5
Number of live births	0.4	0.5	1.4	0.8	0.5	0.6	0.1	-0.7	-1.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.2	0.3	0.5	-0.4	0.0	-0.2
Pulse rate	0.6	1.0	2.2	-0.3	-0.8	-1.4	1.5	0.9	0.5
Happiness	1.4	1.7	2.8	-1.7	-1.2	-1.3	1.3	1.4	-0.6
Noisy workplace	0.8	1.0	2.4	0.4	0.8	1.1	-0.9	-0.8	1.6
Qualifications: A levels/AS levels or equivalent	1.5	3.2	4.5	-2.1	-1.6	-2.1	1.2	1.8	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	0.2	0.4	0.6	-1.0	-0.4	-0.1
Mouth/teeth dental problems: Dentures	1.6	2.7	3.6	1.6	1.5	1.8	-1.4	-1.7	1.9
Asthma	0.2	0.3	1.2	0.5	0.5	0.4	-1.1	-0.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	-0.1	0.1	0.3	0.1	-0.2
Medication: Cholesterol lowering	0.6	0.9	1.6	-0.7	-0.8	-0.9	1.1	0.7	-1.3
Depression (self-reported)	0.2	0.3	1.2	-0.1	0.1	0.3	-0.5	-0.2	1.1
Medication: Lansoprazole	0.4	0.4	0.7	0.6	0.9	0.5	-0.5	-0.9	-0.5
Prospective memory result	1.1	1.4	2.4	0.8	1.0	1.2	-1.4	-0.9	1.5
Lung cancer (father)	3.8	4.5	5.3	1.7	2.3	2.3	-1.9	-2.2	2.2
Illnesses of mother	0.2	0.2	0.6	-0.4	-0.6	-0.2	0.2	0.8	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.8	-0.7	-0.7	-0.8	0.6	0.9	-0.8
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-0.4	-0.3	-0.5	1.0	0.8	0.5
Impedance of arm (left)	0.5	2.5	9.3	0.6	1.1	0.9	-1.5	-0.9	3.0
Arm fat mass (right)	0.5	1.9	7.1	-0.2	0.2	1.3	-2.7	-0.2	1.6
Trunk predicted mass	0.7	4.1	9.5	-1.9	-2.0	-1.5	1.2	1.9	-3.1
Standing height	0.3	2.6	3.3	-1.7	-1.8	-1.5	1.1	1.8	-1.7
Length of working week for main job	2.0	2.2	3.3	-1.8	-1.4	-1.8	1.2	1.5	-1.1
Exposure to tobacco smoke at home	1.0	1.1	1.9	1.4	1.1	1.0	-0.0	-1.1	1.2
Breastfed as a baby	0.3	0.3	0.8	0.3	0.6	0.6	-0.9	-0.6	-0.0
Tense / ‘highly strung’	0.2	0.4	1.1	-0.5	-0.6	-0.5	1.1	0.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.3	0.7	0.7	1.0	-1.5	-0.8	1.1
Hair/balding pattern: Pattern 4	0.1	0.3	1.4	0.2	0.1	0.4	-1.2	-0.1	-0.1
Birth weight of first child	0.4	0.8	1.2	1.0	0.8	1.1	-1.0	-0.7	0.5
Peak expiratory flow (PEF)	0.3	0.6	1.5	0.7	0.8	1.0	-0.1	-0.5	1.2
Pulse wave reflection index	0.6	0.8	1.3	0.8	0.8	1.1	-0.7	-0.5	1.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.1	0.6	0.3	-0.3	-0.6	-0.7
Loud music exposure frequency	0.1	0.2	0.3	-0.6	-0.5	-0.2	-0.2	0.6	0.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.0	-1.2	-1.3	-1.4	0.8	1.2	-0.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	2.7	-1.6	-1.5	-1.1	0.2	1.6	-1.2
Blood clot in the leg (DVT)	0.0	0.1	0.1	0.3	0.1	0.3	-0.1	-0.2	-0.2
Medication: Paracetamol	1.8	2.9	4.3	1.6	2.1	2.1	-0.6	-2.0	1.3
Headache pain in last month	2.4	4.2	6.8	1.8	2.4	2.4	-1.5	-2.6	1.1
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	4.5	2.0	1.7	2.1	-1.9	-1.8	1.9
Glaucoma (self-reported)	1.3	1.6	3.2	-1.8	-1.2	-1.4	0.5	1.6	0.1
Gout (self-reported)	0.1	0.2	0.9	-0.2	0.0	-0.0	-0.9	-0.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.4	0.0	-0.8	-0.7	1.1	0.6	-1.2
Medication: Amlodipine	1.7	2.4	4.0	-1.4	-1.2	-1.6	2.0	1.1	-1.8
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.8	1.3	1.3	1.0	-0.8	-1.2	-0.4
Birth weight	0.2	0.4	0.7	0.3	0.7	0.8	-0.6	-0.6	-0.7
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.7	1.2	0.9	1.3	-1.3	-0.9	0.3
High blood pressure (siblings)	0.8	1.1	2.1	0.9	1.4	1.1	-0.6	-1.5	0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.6	-0.7	-0.6	-0.0	0.9	-0.5
Body fat percentage	2.0	8.0	14.4	1.3	2.0	3.2	-3.8	-1.9	3.8
Leg fat percentage (right)	2.4	8.8	12.7	1.9	2.6	3.6	-3.4	-2.5	3.4
Arm fat-free mass (right)	0.4	1.9	3.3	-1.6	-1.6	-0.8	0.2	1.6	-1.8
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.2	-0.4	-0.1	0.1	0.3	-0.6
Comparative body size at age 10	0.1	0.3	1.5	-0.3	-0.1	0.5	-1.2	0.0	-0.2
Number of full brothers	0.6	0.8	1.4	0.7	1.1	1.0	-0.0	-1.2	0.6
Worry too long after embarrassment	1.5	2.6	4.3	-2.1	-1.5	-1.6	1.3	1.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	3.8	1.3	1.4	1.1	-1.4	-1.2	1.9
Wheeze or whistling in the chest in last year	1.9	3.5	4.3	2.1	1.8	2.0	-1.9	-1.7	1.6
Number of children fathered	0.8	0.9	1.5	1.0	0.9	1.0	-0.9	-0.6	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.5	-0.6	-0.7	0.1	0.7	-0.1
Age at first live birth	3.9	6.9	10.8	-3.3	-2.8	-2.9	2.0	3.1	0.5
Pulse wave peak to peak time	0.3	0.3	0.8	0.1	0.1	0.2	-0.8	-0.6	-0.9
Health satisfaction	0.1	0.2	0.8	-0.3	-0.0	-0.1	-0.2	0.4	0.9
Shortness of breath walking on level ground	1.0	1.2	1.7	1.2	1.2	1.1	-1.1	-1.3	0.3
Qualifications: College or University degree	2.2	6.8	8.6	-2.9	-2.7	-2.8	1.9	2.7	-2.5
Eye problems/disorders: None of the above	2.0	2.3	5.3	-1.6	-1.5	-1.1	0.1	1.4	-2.3
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.7	1.6	1.5	1.6	-1.5	-1.3	0.9
Emphysema/chronic bronchitis	3.2	3.6	5.1	2.3	2.0	2.1	-1.4	-1.9	1.6
Medication for pain relief, constipation, heartburn	0.2	0.4	1.4	-0.4	-0.4	-0.3	-0.7	0.5	1.2
Neck or shoulder pain in last month	1.0	1.4	4.1	-0.1	-0.4	-0.5	2.0	0.3	-2.0
Medication: Blood pressure	2.7	4.8	6.0	-2.2	-1.8	-2.5	2.3	2.0	-2.3
Angina (self-reported)	0.0	0.1	0.2	-0.5	-0.1	-0.2	0.2	0.0	0.2
Migraine (self-reported)	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.0	-0.1	-0.4
Medication: Ibuprofen	0.6	0.7	1.2	-0.4	-1.0	-0.8	1.1	0.9	-0.6
Medication: Allopurinol	0.8	1.0	2.5	-1.6	-1.0	-0.9	-0.5	1.2	0.0
Medication: Omeprazole	0.1	0.1	0.2	0.2	0.5	0.2	0.0	-0.5	-0.2
Medication: Seretide 50 evohaler	3.6	4.1	7.6	2.8	2.2	2.1	-1.3	-2.2	1.0
Mean time to correctly identify matches	1.0	1.8	3.1	-1.6	-1.6	-1.8	0.4	1.6	0.2
Heart disease (mother)	0.1	0.2	0.4	0.3	0.3	0.3	-0.5	-0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-1.1	-0.9	-0.7	0.2	0.8	-0.3
Whole body fat mass	1.1	4.5	10.8	0.6	1.2	2.5	-3.3	-1.2	2.7
Leg fat mass (right)	1.0	3.9	10.0	0.5	1.1	2.3	-3.2	-1.1	2.3
Arm predicted mass (right)	0.3	1.7	2.9	-1.5	-1.6	-0.7	0.2	1.5	-1.7
Pulse rate, automated reading	0.1	0.3	1.7	0.0	0.1	-0.6	1.3	-0.1	0.1
Alcohol intake frequency.	0.2	0.6	2.3	0.8	0.4	0.3	0.2	-0.3	1.5
Comparative height size at age 10	0.0	0.1	0.2	0.1	0.3	0.2	0.2	-0.4	-0.1
Number of full sisters	0.8	0.9	3.0	0.2	0.7	0.8	-0.9	-0.6	1.7
Suffer from ‘nerves’	0.0	0.1	0.2	-0.1	0.1	0.0	0.4	-0.0	0.4
Overall health rating	0.5	1.2	3.2	1.0	1.0	0.9	0.3	-0.9	1.8
Chest pain or discomfort	0.3	0.4	0.6	0.8	0.6	0.3	0.5	-0.8	-0.8
Had major operations	1.1	1.3	2.0	1.4	1.3	0.9	-1.0	-1.3	0.8
Age at last live birth	2.0	2.8	4.4	-2.1	-1.8	-1.6	1.8	1.8	0.4
Family relationship satisfaction	0.5	0.6	1.9	-1.4	-0.6	-0.5	-0.4	0.9	0.6
Leg pain on walking	0.3	0.4	1.0	1.0	0.8	0.4	-0.4	-0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.6	0.1	0.6	-0.1	-0.1	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.3	0.1	-0.3	0.4	-0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.7	-0.9	-1.1	-1.6	1.4	1.1	-1.5
Medication: Aspirin	0.3	0.4	1.5	-0.2	-0.4	-0.4	0.7	0.1	-1.2
Supplements: Vitamin C	1.2	1.4	3.6	1.9	1.2	0.9	-0.0	-1.5	0.5
Knee pain experienced in last month	1.9	2.9	4.9	1.9	2.1	2.2	-1.1	-1.8	0.0
Hypertension (Self-reported)	4.0	11.0	18.3	-3.0	-2.9	-3.1	4.3	2.7	-3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.4	2.8	4.5	1.7	2.1	1.7	-1.3	-2.0	0.8
Illnesses of father: Heart disease	2.2	3.0	6.7	-1.1	-1.7	-1.8	2.6	1.3	-1.6
Illnesses of siblings: Diabetes	2.4	2.9	5.6	1.4	2.4	1.7	-1.4	-2.1	0.7
Smoking status: Previous	0.7	1.1	2.9	1.1	0.9	0.9	0.0	-0.9	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.7	-1.3	-1.2	-0.9	0.4	1.3	0.5
Whole body fat-free mass	0.7	3.8	6.6	-2.1	-2.2	-1.4	0.5	2.1	-2.6
Leg fat-free mass (right)	0.8	4.4	6.7	-2.6	-2.5	-1.6	-0.2	2.5	-2.1
Arm fat percentage (left)	0.9	3.5	10.2	0.3	0.8	1.9	-3.2	-0.8	2.4
Average weekly red wine intake	0.9	1.4	5.1	-0.5	-0.6	-0.9	1.2	0.5	-2.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.9	-0.5	-0.6	-0.4	0.9	0.2	-2.0
Mood swings	0.1	0.3	0.4	-0.7	-0.6	-0.4	0.3	0.5	0.5
Loneliness, isolation	0.7	0.9	1.6	1.0	0.9	0.7	-0.7	-1.1	-1.3
Long-standing illness, disability or infirmity	1.3	2.0	3.1	1.2	1.4	1.4	-1.8	-1.4	1.3
Ever had bowel cancer screening	3.2	3.7	4.9	1.7	2.1	2.2	-2.2	-2.1	0.9
Diabetes diagnosed by doctor	0.1	0.2	1.1	0.2	0.1	-0.2	0.2	0.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.7	-0.7	-0.5	0.1	0.6	-0.3
Friendships satisfaction	0.2	0.2	0.8	-0.6	0.0	0.2	-0.9	0.1	0.4
Qualifications: nursing, teaching	2.6	4.1	5.7	-2.2	-2.2	-2.4	1.7	2.3	-1.1
Commuting to job workplace: Walk	2.3	2.5	3.8	-1.9	-1.9	-1.6	1.2	1.9	-0.5
Eye problems/disorders: Cataract	1.0	1.1	2.5	1.6	1.1	0.7	0.9	-1.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	2.0	0.4	0.3	0.1	0.3	-0.2	-1.4
Medication for cholesterol	0.2	0.2	0.5	-0.7	-0.4	-0.3	-0.7	0.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.4	0.3	0.2	0.2	-0.2
Back pain experienced in last month	0.9	1.3	2.7	1.2	1.1	1.6	-0.8	-1.2	0.7
Mineral and other dietary supplements	0.3	0.4	2.0	-0.5	0.4	0.1	-0.1	-0.2	-1.4
Breast cancer (self-reported)	0.4	0.4	1.4	0.5	0.5	0.6	-1.2	-0.6	0.0
Asthma (self-reported)	0.2	0.3	1.3	0.5	0.4	0.4	-1.2	-0.2	0.2
Osteoporosis (self-reported)	0.4	0.5	1.3	0.6	-0.6	-0.4	0.5	0.6	-1.2
Osteoarthritis (self-reported)	0.4	0.5	1.2	1.1	0.5	0.6	-0.3	-0.8	0.8
Medication: Aspirin	0.7	1.0	2.9	-0.4	-0.7	-0.9	1.1	0.4	-1.7
Medication: Gliclazide	0.6	0.7	2.1	0.2	0.2	-0.1	1.3	-0.2	-1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	0.8	-0.7	-0.6	-0.9	-0.9	0.7	0.7
Smoking status: Current	1.3	2.1	3.5	1.9	1.8	1.5	-0.2	-1.9	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.0	0.7	0.0	0.0	0.7	0.0	-1.0
Whole body water mass	0.7	4.1	6.9	-2.2	-2.3	-1.6	0.6	2.2	-2.6
Leg predicted mass (right)	0.9	4.7	7.1	-2.7	-2.6	-1.7	-0.1	2.6	-2.2
Arm fat mass (left)	0.5	2.0	7.3	-0.0	0.3	1.5	-2.7	-0.3	1.6
Number of self-reported non-cancer illnesses	1.4	2.4	5.5	-1.1	-1.3	-1.5	1.6	1.1	-2.3
Average weekly champagne plus white wine intake	0.3	0.4	1.2	-0.3	-0.6	-0.4	-0.4	0.7	-1.1
Miserableness	0.1	0.2	0.3	0.5	0.5	0.6	-0.4	-0.5	-0.5
Guilty feelings	0.2	0.4	1.2	-0.4	-0.3	0.0	-0.9	0.1	-1.1
Wears glasses or contact lenses	0.4	0.4	1.4	1.0	0.2	-0.1	1.2	-0.1	0.2
Ever taken oral contraceptive pill	1.3	1.4	3.9	-0.9	-1.1	-1.3	2.0	1.0	-0.2
Hearing aid user	0.2	0.2	0.5	-0.5	-0.4	-0.7	0.4	0.5	0.2
Mother’s age at death	0.4	0.5	1.1	-0.6	-0.8	-1.1	-0.0	0.6	-0.6
Financial situation satisfaction	0.1	0.1	0.3	0.2	0.2	0.5	-0.5	-0.3	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.5	0.8	0.6	0.1	-0.5	-0.6	-1.2
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.8	-0.7	-0.5	0.3	0.8	-0.1
Eye problems/disorders: Glaucoma	1.6	1.9	3.4	-1.8	-1.3	-1.6	1.0	1.6	0.1
Medication: Blood pressure	1.1	2.2	3.5	-1.3	-1.3	-1.3	1.9	1.1	-1.8
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	0.7	0.4	0.5	0.9	-0.6	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	0.9	0.2	0.3	-0.3	-0.4	1.1
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.2	0.2	-0.5
Medication: Bendroflumethiazide	1.1	1.7	2.4	-1.5	-1.1	-1.4	1.0	1.2	-1.6
Medication: Paracetamol	1.3	1.9	3.0	1.6	1.7	1.6	-0.4	-1.7	0.8
Medication: Lisinopril	2.3	2.9	4.2	-1.8	-2.1	-1.8	1.4	2.0	-0.9
Medication: Atorvastatin	0.7	0.8	2.2	-0.4	0.0	-0.5	1.5	-0.0	-1.5
Illnesses of father: High blood pressure	0.7	0.9	1.8	-0.8	-0.7	-0.7	1.4	0.4	-1.3
Alcohol drinker status: Never	1.1	1.4	3.0	1.7	1.3	1.0	-0.4	-1.4	0.7
Ever smoked	0.3	0.5	1.2	-0.5	-0.7	-0.7	1.1	0.5	-0.7
Basal metabolic rate	0.4	2.3	3.3	-1.8	-1.8	-0.9	-0.2	1.7	-1.8
Leg fat percentage (left)	1.8	6.5	10.6	1.6	2.0	3.1	-2.8	-2.0	3.2
Arm fat-free mass (left)	0.3	1.5	3.4	-1.3	-1.4	-0.6	0.2	1.3	-1.8
Number of operations (self-reported)	0.7	1.0	2.6	1.0	0.8	0.9	-0.5	-0.9	1.6
Average weekly beer plus cider intake	0.4	0.5	1.6	-0.6	-0.7	-0.1	-0.4	0.8	1.3
Irritability	0.9	1.6	3.2	-1.5	-1.2	-0.9	0.8	1.1	-1.8
Risk taking	0.2	0.3	0.5	0.4	0.6	0.7	0.5	-0.6	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.5	0.3	0.6	0.2	-0.5	0.3
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.8	0.2	0.4	0.7	-0.3	-0.1
Age started oral contraceptive pill	0.1	0.2	0.5	-0.4	-0.3	-0.1	-0.7	0.5	-0.4
Diastolic blood pressure, automated reading	0.3	0.9	1.5	-1.2	-1.0	-0.7	1.1	0.9	0.4
Ever depressed for a whole week	0.6	0.8	1.5	1.1	1.1	0.7	-0.3	-1.2	-0.6
Unable to work because of sickness or disability	3.7	4.8	10.1	3.2	2.1	2.2	-0.9	-2.2	2.0
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.3	0.0	-0.5
Myopia	0.6	0.9	3.2	0.5	0.8	0.9	-1.8	-0.5	0.1
Vascular/heart problems diagnosed by doctor	3.3	9.0	16.9	2.6	2.5	2.8	-4.1	-2.3	3.3
Cholesterol lowering medication	0.5	0.7	1.3	-1.1	-0.8	-0.7	0.6	0.8	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.4	0.3	0.3	-0.4	-0.3	-0.1
Pain experienced in last month	2.7	4.5	7.6	-2.0	-2.4	-2.8	1.6	2.2	-1.5
Supplements: Calcium	0.2	0.2	0.4	0.5	-0.2	0.1	0.6	0.2	0.7
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.5	-0.6	0.1	0.0	0.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.2	0.3	-0.2	0.1	-0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.5	0.1	-0.1	-0.1	0.2	-0.1	-0.7
Heart disease (siblings)	0.1	0.1	0.2	-0.5	0.4	0.4	-0.3	-0.4	0.1
Alcohol drinker status: Previous	1.0	1.1	2.0	-1.1	-1.2	-1.1	0.9	1.4	0.4
Pack years of smoking	0.3	0.4	0.8	0.0	0.8	0.9	-0.3	-0.9	0.5
Impedance of whole body	1.2	6.0	14.4	2.0	2.4	2.1	-1.4	-2.2	3.8
Leg fat mass (left)	0.8	3.1	7.9	0.3	0.8	2.0	-2.8	-0.8	2.2
Arm predicted mass (left)	0.2	1.0	2.3	-0.9	-1.2	-0.3	-0.1	1.1	-1.5