Hub : Genes

UBE2I

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0510 0.0220 1.0e-02 0.053 0.006 0.032 0.019 0.038 4.9e-07 5.8e-02 7.2e-05 1.9e-03 1.7e-05
2 GTEx Artery Tibial 0.1271 0.0357 1.2e-05 0.152 NA 0.139 NA 0.147 6.2e-12 NA 4.8e-11 NA 1.4e-11
3 GTEx Esophagus Muscularis 0.2050 0.0560 2.1e-05 0.101 NA 0.088 NA 0.075 1.1e-06 NA 5.1e-06 NA 2.7e-05
4 YFS Blood 0.0860 0.0186 2.0e-10 0.038 0.033 0.040 0.037 0.046 1.2e-12 5.0e-11 4.4e-13 2.8e-12 9.8e-15
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0205 0.0113 6.1e-03 0.029 0.014 0.015 NA 0.018 2.6e-04 8.3e-03 7.0e-03 NA 3.4e-03
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0349 0.0190 5.3e-03 0.004 0.018 0.010 NA 0.007 1.0e-01 3.7e-03 2.4e-02 NA 5.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.4 1.2 0.6 0.1 -0.0 -1.1 0.0 0.8
Bipolar Disorder or Schizophrenia 1.1 2.7 5.6 1.4 1.5 1.5 -2.4 -1.5 1.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.5 0.4 0.6 -0.5 -0.5 0.4
Depression (Nagel 2018) 0.1 0.2 0.9 0.2 -0.1 0.2 0.2 -0.3 0.9
Intelligence (Savage-Jansen 2018) 0.6 1.8 6.6 -0.6 -1.0 -1.5 -0.0 0.9 -2.6
Neuroticism (Nagel 2018) 0.2 0.4 1.1 -1.0 -0.7 -0.5 -0.1 0.8 -0.0
Schizophrenia (2018) 1.4 3.0 4.7 1.4 1.7 1.9 -2.2 -2.0 0.9
Schizophrenia vs Biploar Disorder 1.2 1.6 3.7 1.5 1.9 1.7 -0.8 0.0 0.0
Worry (Nagel 2018) 0.7 1.5 2.3 -1.4 -1.5 -1.2 1.1 1.5 0.1
Alzheimer’s Disease (in mother) 1.8 2.1 3.1 1.4 1.8 1.4 -0.9 -1.7 1.4
Alzheimer’s Disease (in father) 1.1 1.1 2.3 1.1 1.4 1.1 -0.4 -1.5 -0.2
Alzheimer’s Disease (including proxy) 2.5 3.7 7.2 1.9 2.7 2.0 -0.8 -2.5 0.6
Crohns Disease (2017) 0.1 0.2 0.5 0.4 0.4 0.2 -0.3 -0.4 -0.7
Irritable Bowel Disease (IBD) 0.1 0.3 0.5 0.5 0.4 0.5 -0.7 -0.4 -0.4
Ulcerative Colitis (UC) 0.0 0.1 0.4 0.0 -0.0 0.3 -0.6 0.0 -0.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.1 2.1 3.4 -1.7 -1.7 -1.9 0.3 1.6 0.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 4.7 0.0 -0.6 -0.6 -0.3 0.2 -2.2
Breast Cancer 2.1 5.1 7.1 2.3 2.5 2.4 -2.0 -2.7 1.6
Ovarian Cancer 0.4 0.6 2.8 0.3 0.4 0.0 0.6 -0.3 -1.7
Prostate Cancer 0.1 0.1 0.6 0.1 -0.2 -0.2 0.8 0.3 -0.2
Age at First Birth 1.3 1.9 2.6 -1.6 -1.5 -1.4 0.9 1.5 -1.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.7 0.1 0.4 0.4 -0.3 -0.2 1.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.4 0.6 2.0 -0.4 -0.7 -0.4 1.4 0.6 -0.6
Mean Putamen Volume 1.5 1.7 2.6 1.2 1.6 1.4 -1.2 -1.5 0.8
Fasting Glucose 1.7 2.0 2.7 -1.5 -1.2 -1.2 1.6 1.5 -1.6
HbA1C 0.2 0.2 0.6 -0.8 -0.3 0.1 0.3 0.5 0.1
HDL Cholesterol 0.4 0.6 2.2 0.1 0.0 -0.4 1.1 -0.0 -1.5
LDL Cholesterol 0.3 0.4 2.0 0.4 0.3 0.2 -1.4 -0.1 0.4
Lupus 1.1 1.7 2.0 1.3 1.4 1.1 -1.1 -1.4 1.4
Neuroticism (2016) 0.2 0.3 0.4 -0.6 -0.6 -0.5 0.4 0.5 -0.6
Primary Biliary Cirrhosis 0.7 0.9 3.6 0.7 0.3 0.8 -0.9 -0.2 1.9
Rheumatoid Arthritis 0.3 0.5 0.9 -0.7 -0.7 -0.5 -0.5 1.0 0.6
Schizophrenia (2014) 1.4 3.1 3.9 1.7 1.8 1.8 -1.9 -2.0 1.4
Triglycerides 1.0 1.7 3.8 1.0 0.8 1.1 -1.6 -0.8 1.9
Type 2 Diabetes (T2D) (2012) 0.3 0.3 2.0 0.0 0.0 0.0 1.4 0.0 0.0
Ulcerative Colitis 0.9 1.3 1.9 -1.1 -1.4 -1.3 0.9 1.2 -0.8
Blood Eosinophil Count 0.1 0.5 3.0 -0.3 0.1 -0.3 0.2 0.2 1.7
Blood Platelet Count 0.1 1.0 5.7 0.0 0.4 -0.1 2.4 -0.6 0.0
Blood Red Count 0.7 6.5 10.3 2.0 2.4 2.7 -3.2 -2.3 2.5
Blood White Count 0.8 5.6 17.3 0.4 0.3 -0.9 3.9 -0.6 -4.2
Heel T-Score 0.0 0.2 0.7 -0.0 -0.1 -0.9 -0.2 0.1 -0.8
BMI 0.1 0.4 1.9 -0.5 0.0 0.7 -1.4 -0.0 0.3
Height 0.3 5.8 12.0 -2.3 -2.4 -2.1 1.6 2.3 -3.5
Waist Hip Ratio (WHR) 0.2 0.7 1.1 0.8 0.9 0.3 0.7 -1.0 -1.0
Systolic Blood Pressure 7.3 36.5 45.7 -6.0 -6.1 -6.8 6.5 6.0 -4.7
Smoking Status 1.1 2.7 4.4 2.1 1.8 1.8 -0.4 -1.9 1.3
Allergy or Eczema 0.2 0.4 1.1 0.9 0.1 0.2 -0.6 -0.1 1.1
Cardiovascular Disease 4.2 13.8 19.8 -3.5 -3.6 -4.0 4.5 3.4 -3.2
Hypothyroidism (self reported) 1.0 2.2 3.7 -0.6 -1.6 -1.7 1.4 1.4 -1.9
Respiratory disease 0.0 0.1 0.5 -0.0 -0.1 0.0 -0.7 0.2 -0.0
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.3 0.6 0.3 -0.0 0.2 -0.2 -0.1
Lung FEV1/FVC ratio 0.2 0.9 3.4 0.7 0.8 0.3 1.9 -0.8 -0.6
Lung FVC 0.2 1.0 1.4 1.1 1.2 1.0 -0.6 -1.1 -0.8
Neuroticism 0.1 0.1 0.4 -0.2 -0.4 -0.0 0.7 0.2 -0.3
Chronotype (morning person) 0.5 1.1 2.5 -0.7 -1.0 -1.6 1.3 0.9 -0.2
Hair Pigment 0.1 4.1 8.0 -2.7 -2.4 -1.7 -0.8 2.8 0.3
Tanning 0.3 3.8 5.9 1.9 2.4 1.9 0.1 -2.1 2.4
Hand grip strength (left) 0.4 1.1 2.3 -1.5 -0.8 -0.9 1.2 0.9 -0.7
Number of treatments/medications taken 0.2 0.4 0.9 0.9 0.5 0.1 0.8 -0.7 -0.2
Average weekly spirits intake 1.3 1.6 2.8 1.0 1.5 1.7 -0.5 -1.5 1.2
Sensitivity / hurt feelings 0.0 0.1 0.1 -0.3 -0.3 -0.1 0.3 0.3 -0.2
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.4 -0.1 -0.3 -0.1 0.6 -0.1 -0.1
Hearing difficulty/problems: Yes 0.1 0.2 0.5 0.5 0.5 0.3 -0.7 -0.4 -0.1
Relative age of first facial hair 1.5 3.2 3.6 -1.8 -1.7 -1.9 1.8 1.8 -1.6
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 1.0 0.3 0.0 0.2 -0.5 -0.0 1.0
Ever used hormone-replacement therapy (HRT) 1.4 1.7 2.7 1.6 1.2 1.4 -1.5 -1.3 0.6
Ever had hysterectomy (womb removed) 0.5 0.6 3.5 -0.2 0.0 -0.1 -0.1 -0.1 -1.9
Systolic blood pressure, automated reading 5.7 16.5 20.1 -4.2 -4.2 -4.5 4.4 4.1 -2.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.4 1.0 1.2 0.9 -1.1 -1.0 0.3
Angina 0.0 0.0 0.1 -0.3 -0.0 -0.1 0.3 -0.1 0.1
Medication for hormone replacement therapy 1.7 1.9 4.0 2.0 1.3 1.5 -0.9 -1.3 1.1
Vitamin and mineral supplements 0.2 0.2 0.8 -0.3 0.4 0.4 -0.9 -0.2 0.4
Supplements: Zinc 0.1 0.1 0.4 0.1 0.0 -0.0 0.7 -0.0 0.5
Medication: Co-codamol 8.6 10.0 11.6 3.1 3.4 3.4 -2.8 -3.4 2.8
Medication: Metformin 0.2 0.2 0.3 0.5 0.5 0.6 -0.5 -0.3 -0.4
Diabetes (father) 0.6 0.7 1.2 0.6 1.1 1.0 -0.4 -1.1 -0.4
Diabetes (mother) 1.6 2.1 4.0 -0.3 -0.8 -1.8 2.0 0.9 -1.9
Severe depression (siblings) 0.2 0.2 0.4 0.4 0.5 0.6 -0.5 -0.5 0.4
Pack years adult smoking proportion 0.2 0.3 0.6 -0.0 0.7 0.7 -0.2 -0.8 0.6
Impedance of leg (right) 2.4 11.6 18.0 3.3 3.8 3.4 -1.3 -3.6 4.2
Leg fat-free mass (left) 0.6 3.3 5.4 -2.3 -2.2 -1.3 -0.6 2.1 -1.8
Trunk fat percentage 2.0 8.0 15.7 1.2 1.9 3.1 -3.8 -1.8 4.0
Hand grip strength (right) 0.6 1.7 2.7 -1.7 -1.1 -1.3 1.6 1.3 -0.6
Townsend deprivation index at recruitment 3.5 5.0 7.1 2.1 2.4 2.7 -1.4 -2.5 2.1
Current tobacco smoking 1.4 2.2 3.6 1.9 1.8 1.5 -0.3 -1.9 0.7
Average weekly fortified wine intake 1.2 1.4 3.1 0.6 1.0 1.1 -1.8 -0.8 1.5
Maternal smoking around birth 0.1 0.2 0.4 0.1 0.4 0.5 -0.1 -0.3 0.6
Fed-up feelings 0.0 0.0 0.1 0.0 0.1 0.3 0.2 -0.2 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.5 -0.3 -0.2 -0.2 0.7 0.1 0.1
Relative age voice broke 1.5 2.3 3.2 -1.0 -1.6 -1.7 1.8 1.3 -1.6
Taking other prescription medications 1.3 2.0 2.9 1.5 1.5 1.3 -0.7 -1.5 1.7
Age when periods started (menarche) 1.3 3.1 6.6 0.7 1.9 1.9 -0.9 -1.7 2.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.1 0.7 0.9 0.9 -0.2 -1.1 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.9 1.0 0.5 0.3 -0.3 -0.4 -0.7
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.6 -1.1 -1.0 -1.0 0.5 1.3 0.1
Qualifications: CSEs or equivalent 2.0 2.6 7.0 1.5 1.1 1.6 -2.7 -0.9 1.4
Serious illness, injury or assault to yourself 1.7 2.0 3.5 1.9 1.2 1.5 -0.7 -1.2 1.7
High blood pressure 3.1 8.8 15.4 -2.6 -2.6 -2.8 3.9 2.3 -3.2
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.6 0.5 -0.1 -0.1 0.1 0.2 0.8
Multivitamins +/- minerals 0.9 1.2 2.0 -0.7 -1.4 -1.1 0.8 1.4 -0.9
Stomach or abdominal pain in last month 0.5 0.6 1.4 -0.8 -0.5 -0.7 1.2 0.6 -0.7
Supplements: Glucosamine 1.6 2.1 3.6 1.8 1.0 1.2 -1.4 -1.2 1.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.5 0.1 -0.0 -0.2 0.7 -0.0 -0.1
Medication: Atenolol 0.9 1.1 2.2 -1.0 -0.9 -1.4 1.5 0.6 -0.7
Medication: Levothyroxine sodium 0.1 0.2 0.9 0.2 -0.0 -0.2 0.5 -0.2 -0.9
Sitting height 0.3 2.1 3.7 -1.8 -1.6 -1.4 0.7 1.9 -0.9
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 0.5 0.7 1.4 -0.6 -0.5 1.3
High blood pressure (mother) 1.5 2.1 3.4 -1.5 -1.5 -1.8 1.5 1.3 -0.9
Body mass index (BMI) 0.3 1.3 5.0 -0.3 0.1 1.2 -2.2 -0.2 1.0
Impedance of leg (left) 2.0 9.6 18.1 3.0 3.3 3.0 -0.9 -3.1 4.3
Leg predicted mass (left) 0.6 3.3 5.2 -2.3 -2.2 -1.3 -0.5 2.1 -1.9
Trunk fat mass 1.0 4.2 9.9 0.5 1.1 2.3 -3.1 -1.0 2.7
Waist circumference 0.2 0.9 3.4 -0.3 0.3 1.1 -1.9 -0.4 0.6
Number of incorrect matches in round 2.6 4.4 10.4 -1.2 -1.8 -2.0 3.2 1.5 -2.2
Past tobacco smoking 0.3 0.5 0.8 -0.9 -0.7 -0.7 -0.3 0.8 -0.7
Alcohol usually taken with meals 2.2 3.6 5.2 -1.8 -2.0 -2.3 1.2 2.2 -1.6
Nervous feelings 0.0 0.1 0.3 0.0 0.1 0.1 0.3 0.1 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.1 -0.2 -0.2 -0.2 0.3 0.0 0.3
Hearing difficulty/problems with background noise 1.0 1.7 3.3 1.8 1.3 1.2 -1.0 -1.6 -0.0
Hair/balding pattern: Pattern 2 0.9 1.1 2.5 1.6 1.0 0.9 -0.9 -1.1 -0.5
Had menopause 0.7 0.9 1.4 -0.5 -0.9 -1.1 1.2 0.8 -0.9
Had other major operations 0.2 0.3 0.8 0.5 -0.0 -0.3 0.9 -0.2 -0.7
Forced vital capacity (FVC) 0.1 0.3 1.0 0.2 0.3 0.7 -1.0 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.0 1.2 0.9 0.7 -1.4 -0.8 0.1
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.3 0.8 1.1 0.9 -0.2 -1.1 0.1
Qualifications: None of the above 4.8 10.3 13.0 3.2 3.6 3.6 -1.9 -3.5 3.1
Financial difficulties in last 2 years 0.6 0.8 1.5 0.7 0.9 1.2 -0.7 -1.2 -0.1
Mouth/teeth dental problems 0.2 0.3 0.6 -0.8 -0.5 -0.6 0.5 0.6 0.3
Heart attack 0.0 0.1 0.2 0.0 0.5 -0.0 -0.1 -0.3 -0.1
Allergy 0.1 0.2 0.5 -0.5 0.0 -0.2 0.4 -0.1 -0.7
Pain all over the body in last month 0.4 0.4 1.3 0.0 -0.6 -0.6 1.1 0.6 0.6
Diabetes (self-reported) 0.1 0.1 0.3 0.3 0.3 0.2 -0.1 -0.2 -0.6
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.3 -0.4 -0.5 -1.1 0.9 0.5 -0.3
Medication: Ramipril 2.0 2.6 4.0 -1.8 -1.5 -2.0 1.4 1.6 -1.1
Medication: Simvastatin 1.8 2.6 3.9 -2.0 -1.8 -1.5 0.9 1.7 -1.6
Fluid intelligence score 1.9 3.9 5.9 -1.7 -2.3 -2.2 0.9 1.9 -2.4
Illnesses of siblings 1.0 1.3 2.4 -0.6 -1.5 -1.3 1.0 1.5 -0.5
Neuroticism score 0.2 0.5 0.8 -0.8 -0.7 -0.5 0.9 0.7 -0.7
Weight 0.2 0.8 2.9 -1.0 -0.6 0.5 -1.7 0.6 0.2
Impedance of arm (right) 0.5 2.2 7.3 0.7 1.1 0.9 -1.5 -1.0 2.7
Arm fat percentage (right) 1.0 3.8 10.8 0.5 1.0 1.9 -3.3 -1.0 2.4
Trunk fat-free mass 0.7 4.1 9.2 -1.9 -2.1 -1.6 1.2 2.0 -3.0
Hip circumference 0.4 1.7 6.4 -0.4 0.1 1.4 -2.5 -0.1 1.4
Time employed in main current job 0.7 0.8 1.1 -0.6 -1.0 -0.8 0.8 0.9 -1.1
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.4 0.5 0.6 0.2 -0.4 0.5
Father’s age at death 0.0 0.1 0.2 0.2 0.1 0.3 -0.1 -0.1 0.4
Worrier / anxious feelings 2.7 5.1 9.8 -3.1 -2.7 -2.2 0.6 2.9 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.6 0.8 0.5 0.5 0.5 -0.7 -0.2
Falls in the last year 0.1 0.2 0.4 0.2 -0.0 0.6 -0.7 -0.3 0.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.4 0.6 0.7 -0.4 -0.4 0.5
Number of live births 0.4 0.5 1.4 0.8 0.5 0.6 0.1 -0.7 -1.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.2 0.2 0.3 0.5 -0.4 0.0 -0.2
Pulse rate 0.6 1.0 2.2 -0.3 -0.8 -1.4 1.5 0.9 0.5
Happiness 1.4 1.7 2.8 -1.7 -1.2 -1.3 1.3 1.4 -0.6
Noisy workplace 0.8 1.0 2.4 0.4 0.8 1.1 -0.9 -0.8 1.6
Qualifications: A levels/AS levels or equivalent 1.5 3.2 4.5 -2.1 -1.6 -2.1 1.2 1.8 -1.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 1.1 0.2 0.4 0.6 -1.0 -0.4 -0.1
Mouth/teeth dental problems: Dentures 1.6 2.7 3.6 1.6 1.5 1.8 -1.4 -1.7 1.9
Asthma 0.2 0.3 1.2 0.5 0.5 0.4 -1.1 -0.2 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 0.2 -0.1 0.1 0.3 0.1 -0.2
Medication: Cholesterol lowering 0.6 0.9 1.6 -0.7 -0.8 -0.9 1.1 0.7 -1.3
Depression (self-reported) 0.2 0.3 1.2 -0.1 0.1 0.3 -0.5 -0.2 1.1
Medication: Lansoprazole 0.4 0.4 0.7 0.6 0.9 0.5 -0.5 -0.9 -0.5
Prospective memory result 1.1 1.4 2.4 0.8 1.0 1.2 -1.4 -0.9 1.5
Lung cancer (father) 3.8 4.5 5.3 1.7 2.3 2.3 -1.9 -2.2 2.2
Illnesses of mother 0.2 0.2 0.6 -0.4 -0.6 -0.2 0.2 0.8 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.8 -0.7 -0.7 -0.8 0.6 0.9 -0.8
Pulse wave Arterial Stiffness index 0.3 0.4 1.0 -0.4 -0.3 -0.5 1.0 0.8 0.5
Impedance of arm (left) 0.5 2.5 9.3 0.6 1.1 0.9 -1.5 -0.9 3.0
Arm fat mass (right) 0.5 1.9 7.1 -0.2 0.2 1.3 -2.7 -0.2 1.6
Trunk predicted mass 0.7 4.1 9.5 -1.9 -2.0 -1.5 1.2 1.9 -3.1
Standing height 0.3 2.6 3.3 -1.7 -1.8 -1.5 1.1 1.8 -1.7
Length of working week for main job 2.0 2.2 3.3 -1.8 -1.4 -1.8 1.2 1.5 -1.1
Exposure to tobacco smoke at home 1.0 1.1 1.9 1.4 1.1 1.0 -0.0 -1.1 1.2
Breastfed as a baby 0.3 0.3 0.8 0.3 0.6 0.6 -0.9 -0.6 -0.0
Tense / ‘highly strung’ 0.2 0.4 1.1 -0.5 -0.6 -0.5 1.1 0.6 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.3 0.7 0.7 1.0 -1.5 -0.8 1.1
Hair/balding pattern: Pattern 4 0.1 0.3 1.4 0.2 0.1 0.4 -1.2 -0.1 -0.1
Birth weight of first child 0.4 0.8 1.2 1.0 0.8 1.1 -1.0 -0.7 0.5
Peak expiratory flow (PEF) 0.3 0.6 1.5 0.7 0.8 1.0 -0.1 -0.5 1.2
Pulse wave reflection index 0.6 0.8 1.3 0.8 0.8 1.1 -0.7 -0.5 1.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.5 -0.1 0.6 0.3 -0.3 -0.6 -0.7
Loud music exposure frequency 0.1 0.2 0.3 -0.6 -0.5 -0.2 -0.2 0.6 0.0
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.0 -1.2 -1.3 -1.4 0.8 1.2 -0.2
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 2.7 -1.6 -1.5 -1.1 0.2 1.6 -1.2
Blood clot in the leg (DVT) 0.0 0.1 0.1 0.3 0.1 0.3 -0.1 -0.2 -0.2
Medication: Paracetamol 1.8 2.9 4.3 1.6 2.1 2.1 -0.6 -2.0 1.3
Headache pain in last month 2.4 4.2 6.8 1.8 2.4 2.4 -1.5 -2.6 1.1
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 4.5 2.0 1.7 2.1 -1.9 -1.8 1.9
Glaucoma (self-reported) 1.3 1.6 3.2 -1.8 -1.2 -1.4 0.5 1.6 0.1
Gout (self-reported) 0.1 0.2 0.9 -0.2 0.0 -0.0 -0.9 -0.0 0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.4 0.0 -0.8 -0.7 1.1 0.6 -1.2
Medication: Amlodipine 1.7 2.4 4.0 -1.4 -1.2 -1.6 2.0 1.1 -1.8
Medication: Ventolin 100micrograms inhaler 0.9 1.1 1.8 1.3 1.3 1.0 -0.8 -1.2 -0.4
Birth weight 0.2 0.4 0.7 0.3 0.7 0.8 -0.6 -0.6 -0.7
Chronic bronchitis/emphysema (mother) 1.0 1.1 1.7 1.2 0.9 1.3 -1.3 -0.9 0.3
High blood pressure (siblings) 0.8 1.1 2.1 0.9 1.4 1.1 -0.6 -1.5 0.2
Forced vital capacity (FVC), Best measure 0.1 0.4 0.8 -0.6 -0.7 -0.6 -0.0 0.9 -0.5
Body fat percentage 2.0 8.0 14.4 1.3 2.0 3.2 -3.8 -1.9 3.8
Leg fat percentage (right) 2.4 8.8 12.7 1.9 2.6 3.6 -3.4 -2.5 3.4
Arm fat-free mass (right) 0.4 1.9 3.3 -1.6 -1.6 -0.8 0.2 1.6 -1.8
Exposure to tobacco smoke outside home 0.1 0.1 0.3 -0.2 -0.4 -0.1 0.1 0.3 -0.6
Comparative body size at age 10 0.1 0.3 1.5 -0.3 -0.1 0.5 -1.2 0.0 -0.2
Number of full brothers 0.6 0.8 1.4 0.7 1.1 1.0 -0.0 -1.2 0.6
Worry too long after embarrassment 1.5 2.6 4.3 -2.1 -1.5 -1.6 1.3 1.4 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 3.8 1.3 1.4 1.1 -1.4 -1.2 1.9
Wheeze or whistling in the chest in last year 1.9 3.5 4.3 2.1 1.8 2.0 -1.9 -1.7 1.6
Number of children fathered 0.8 0.9 1.5 1.0 0.9 1.0 -0.9 -0.6 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.5 -0.5 -0.6 -0.7 0.1 0.7 -0.1
Age at first live birth 3.9 6.9 10.8 -3.3 -2.8 -2.9 2.0 3.1 0.5
Pulse wave peak to peak time 0.3 0.3 0.8 0.1 0.1 0.2 -0.8 -0.6 -0.9
Health satisfaction 0.1 0.2 0.8 -0.3 -0.0 -0.1 -0.2 0.4 0.9
Shortness of breath walking on level ground 1.0 1.2 1.7 1.2 1.2 1.1 -1.1 -1.3 0.3
Qualifications: College or University degree 2.2 6.8 8.6 -2.9 -2.7 -2.8 1.9 2.7 -2.5
Eye problems/disorders: None of the above 2.0 2.3 5.3 -1.6 -1.5 -1.1 0.1 1.4 -2.3
Mouth/teeth dental problems: Loose teeth 1.7 2.0 2.7 1.6 1.5 1.6 -1.5 -1.3 0.9
Emphysema/chronic bronchitis 3.2 3.6 5.1 2.3 2.0 2.1 -1.4 -1.9 1.6
Medication for pain relief, constipation, heartburn 0.2 0.4 1.4 -0.4 -0.4 -0.3 -0.7 0.5 1.2
Neck or shoulder pain in last month 1.0 1.4 4.1 -0.1 -0.4 -0.5 2.0 0.3 -2.0
Medication: Blood pressure 2.7 4.8 6.0 -2.2 -1.8 -2.5 2.3 2.0 -2.3
Angina (self-reported) 0.0 0.1 0.2 -0.5 -0.1 -0.2 0.2 0.0 0.2
Migraine (self-reported) 0.0 0.0 0.1 -0.1 -0.1 -0.2 -0.0 -0.1 -0.4
Medication: Ibuprofen 0.6 0.7 1.2 -0.4 -1.0 -0.8 1.1 0.9 -0.6
Medication: Allopurinol 0.8 1.0 2.5 -1.6 -1.0 -0.9 -0.5 1.2 0.0
Medication: Omeprazole 0.1 0.1 0.2 0.2 0.5 0.2 0.0 -0.5 -0.2
Medication: Seretide 50 evohaler 3.6 4.1 7.6 2.8 2.2 2.1 -1.3 -2.2 1.0
Mean time to correctly identify matches 1.0 1.8 3.1 -1.6 -1.6 -1.8 0.4 1.6 0.2
Heart disease (mother) 0.1 0.2 0.4 0.3 0.3 0.3 -0.5 -0.1 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.2 -1.1 -0.9 -0.7 0.2 0.8 -0.3
Whole body fat mass 1.1 4.5 10.8 0.6 1.2 2.5 -3.3 -1.2 2.7
Leg fat mass (right) 1.0 3.9 10.0 0.5 1.1 2.3 -3.2 -1.1 2.3
Arm predicted mass (right) 0.3 1.7 2.9 -1.5 -1.6 -0.7 0.2 1.5 -1.7
Pulse rate, automated reading 0.1 0.3 1.7 0.0 0.1 -0.6 1.3 -0.1 0.1
Alcohol intake frequency. 0.2 0.6 2.3 0.8 0.4 0.3 0.2 -0.3 1.5
Comparative height size at age 10 0.0 0.1 0.2 0.1 0.3 0.2 0.2 -0.4 -0.1
Number of full sisters 0.8 0.9 3.0 0.2 0.7 0.8 -0.9 -0.6 1.7
Suffer from ‘nerves’ 0.0 0.1 0.2 -0.1 0.1 0.0 0.4 -0.0 0.4
Overall health rating 0.5 1.2 3.2 1.0 1.0 0.9 0.3 -0.9 1.8
Chest pain or discomfort 0.3 0.4 0.6 0.8 0.6 0.3 0.5 -0.8 -0.8
Had major operations 1.1 1.3 2.0 1.4 1.3 0.9 -1.0 -1.3 0.8
Age at last live birth 2.0 2.8 4.4 -2.1 -1.8 -1.6 1.8 1.8 0.4
Family relationship satisfaction 0.5 0.6 1.9 -1.4 -0.6 -0.5 -0.4 0.9 0.6
Leg pain on walking 0.3 0.4 1.0 1.0 0.8 0.4 -0.4 -0.6 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.4 0.6 0.1 0.6 -0.1 -0.1 0.2
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.3 0.1 -0.3 0.4 -0.2 -0.5
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 2.7 -0.9 -1.1 -1.6 1.4 1.1 -1.5
Medication: Aspirin 0.3 0.4 1.5 -0.2 -0.4 -0.4 0.7 0.1 -1.2
Supplements: Vitamin C 1.2 1.4 3.6 1.9 1.2 0.9 -0.0 -1.5 0.5
Knee pain experienced in last month 1.9 2.9 4.9 1.9 2.1 2.2 -1.1 -1.8 0.0
Hypertension (Self-reported) 4.0 11.0 18.3 -3.0 -2.9 -3.1 4.3 2.7 -3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.4 2.8 4.5 1.7 2.1 1.7 -1.3 -2.0 0.8
Illnesses of father: Heart disease 2.2 3.0 6.7 -1.1 -1.7 -1.8 2.6 1.3 -1.6
Illnesses of siblings: Diabetes 2.4 2.9 5.6 1.4 2.4 1.7 -1.4 -2.1 0.7
Smoking status: Previous 0.7 1.1 2.9 1.1 0.9 0.9 0.0 -0.9 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.7 -1.3 -1.2 -0.9 0.4 1.3 0.5
Whole body fat-free mass 0.7 3.8 6.6 -2.1 -2.2 -1.4 0.5 2.1 -2.6
Leg fat-free mass (right) 0.8 4.4 6.7 -2.6 -2.5 -1.6 -0.2 2.5 -2.1
Arm fat percentage (left) 0.9 3.5 10.2 0.3 0.8 1.9 -3.2 -0.8 2.4
Average weekly red wine intake 0.9 1.4 5.1 -0.5 -0.6 -0.9 1.2 0.5 -2.2
Handedness (chirality/laterality): Left-handed 0.8 0.9 3.9 -0.5 -0.6 -0.4 0.9 0.2 -2.0
Mood swings 0.1 0.3 0.4 -0.7 -0.6 -0.4 0.3 0.5 0.5
Loneliness, isolation 0.7 0.9 1.6 1.0 0.9 0.7 -0.7 -1.1 -1.3
Long-standing illness, disability or infirmity 1.3 2.0 3.1 1.2 1.4 1.4 -1.8 -1.4 1.3
Ever had bowel cancer screening 3.2 3.7 4.9 1.7 2.1 2.2 -2.2 -2.1 0.9
Diabetes diagnosed by doctor 0.1 0.2 1.1 0.2 0.1 -0.2 0.2 0.0 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 -0.7 -0.7 -0.5 0.1 0.6 -0.3
Friendships satisfaction 0.2 0.2 0.8 -0.6 0.0 0.2 -0.9 0.1 0.4
Qualifications: nursing, teaching 2.6 4.1 5.7 -2.2 -2.2 -2.4 1.7 2.3 -1.1
Commuting to job workplace: Walk 2.3 2.5 3.8 -1.9 -1.9 -1.6 1.2 1.9 -0.5
Eye problems/disorders: Cataract 1.0 1.1 2.5 1.6 1.1 0.7 0.9 -1.2 0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 2.0 0.4 0.3 0.1 0.3 -0.2 -1.4
Medication for cholesterol 0.2 0.2 0.5 -0.7 -0.4 -0.3 -0.7 0.5 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.4 -0.4 0.3 0.2 0.2 -0.2
Back pain experienced in last month 0.9 1.3 2.7 1.2 1.1 1.6 -0.8 -1.2 0.7
Mineral and other dietary supplements 0.3 0.4 2.0 -0.5 0.4 0.1 -0.1 -0.2 -1.4
Breast cancer (self-reported) 0.4 0.4 1.4 0.5 0.5 0.6 -1.2 -0.6 0.0
Asthma (self-reported) 0.2 0.3 1.3 0.5 0.4 0.4 -1.2 -0.2 0.2
Osteoporosis (self-reported) 0.4 0.5 1.3 0.6 -0.6 -0.4 0.5 0.6 -1.2
Osteoarthritis (self-reported) 0.4 0.5 1.2 1.1 0.5 0.6 -0.3 -0.8 0.8
Medication: Aspirin 0.7 1.0 2.9 -0.4 -0.7 -0.9 1.1 0.4 -1.7
Medication: Gliclazide 0.6 0.7 2.1 0.2 0.2 -0.1 1.3 -0.2 -1.4
Illnesses of father: None of the above (group 1) 0.5 0.6 0.8 -0.7 -0.6 -0.9 -0.9 0.7 0.7
Smoking status: Current 1.3 2.1 3.5 1.9 1.8 1.5 -0.2 -1.9 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 1.0 0.7 0.0 0.0 0.7 0.0 -1.0
Whole body water mass 0.7 4.1 6.9 -2.2 -2.3 -1.6 0.6 2.2 -2.6
Leg predicted mass (right) 0.9 4.7 7.1 -2.7 -2.6 -1.7 -0.1 2.6 -2.2
Arm fat mass (left) 0.5 2.0 7.3 -0.0 0.3 1.5 -2.7 -0.3 1.6
Number of self-reported non-cancer illnesses 1.4 2.4 5.5 -1.1 -1.3 -1.5 1.6 1.1 -2.3
Average weekly champagne plus white wine intake 0.3 0.4 1.2 -0.3 -0.6 -0.4 -0.4 0.7 -1.1
Miserableness 0.1 0.2 0.3 0.5 0.5 0.6 -0.4 -0.5 -0.5
Guilty feelings 0.2 0.4 1.2 -0.4 -0.3 0.0 -0.9 0.1 -1.1
Wears glasses or contact lenses 0.4 0.4 1.4 1.0 0.2 -0.1 1.2 -0.1 0.2
Ever taken oral contraceptive pill 1.3 1.4 3.9 -0.9 -1.1 -1.3 2.0 1.0 -0.2
Hearing aid user 0.2 0.2 0.5 -0.5 -0.4 -0.7 0.4 0.5 0.2
Mother’s age at death 0.4 0.5 1.1 -0.6 -0.8 -1.1 -0.0 0.6 -0.6
Financial situation satisfaction 0.1 0.1 0.3 0.2 0.2 0.5 -0.5 -0.3 -0.3
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.5 0.8 0.6 0.1 -0.5 -0.6 -1.2
Commuting to job workplace: Public transport 0.3 0.4 0.6 -0.8 -0.7 -0.5 0.3 0.8 -0.1
Eye problems/disorders: Glaucoma 1.6 1.9 3.4 -1.8 -1.3 -1.6 1.0 1.6 0.1
Medication: Blood pressure 1.1 2.2 3.5 -1.3 -1.3 -1.3 1.9 1.1 -1.8
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.8 0.7 0.4 0.5 0.9 -0.6 0.1
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 0.9 0.2 0.3 -0.3 -0.4 1.1
High cholesterol (Self-reported) 0.1 0.1 0.3 -0.5 -0.4 -0.2 -0.2 0.2 -0.5
Medication: Bendroflumethiazide 1.1 1.7 2.4 -1.5 -1.1 -1.4 1.0 1.2 -1.6
Medication: Paracetamol 1.3 1.9 3.0 1.6 1.7 1.6 -0.4 -1.7 0.8
Medication: Lisinopril 2.3 2.9 4.2 -1.8 -2.1 -1.8 1.4 2.0 -0.9
Medication: Atorvastatin 0.7 0.8 2.2 -0.4 0.0 -0.5 1.5 -0.0 -1.5
Illnesses of father: High blood pressure 0.7 0.9 1.8 -0.8 -0.7 -0.7 1.4 0.4 -1.3
Alcohol drinker status: Never 1.1 1.4 3.0 1.7 1.3 1.0 -0.4 -1.4 0.7
Ever smoked 0.3 0.5 1.2 -0.5 -0.7 -0.7 1.1 0.5 -0.7
Basal metabolic rate 0.4 2.3 3.3 -1.8 -1.8 -0.9 -0.2 1.7 -1.8
Leg fat percentage (left) 1.8 6.5 10.6 1.6 2.0 3.1 -2.8 -2.0 3.2
Arm fat-free mass (left) 0.3 1.5 3.4 -1.3 -1.4 -0.6 0.2 1.3 -1.8
Number of operations (self-reported) 0.7 1.0 2.6 1.0 0.8 0.9 -0.5 -0.9 1.6
Average weekly beer plus cider intake 0.4 0.5 1.6 -0.6 -0.7 -0.1 -0.4 0.8 1.3
Irritability 0.9 1.6 3.2 -1.5 -1.2 -0.9 0.8 1.1 -1.8
Risk taking 0.2 0.3 0.5 0.4 0.6 0.7 0.5 -0.6 0.4
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.4 0.5 0.3 0.6 0.2 -0.5 0.3
Fractured/broken bones in last 5 years 0.2 0.2 0.6 0.8 0.2 0.4 0.7 -0.3 -0.1
Age started oral contraceptive pill 0.1 0.2 0.5 -0.4 -0.3 -0.1 -0.7 0.5 -0.4
Diastolic blood pressure, automated reading 0.3 0.9 1.5 -1.2 -1.0 -0.7 1.1 0.9 0.4
Ever depressed for a whole week 0.6 0.8 1.5 1.1 1.1 0.7 -0.3 -1.2 -0.6
Unable to work because of sickness or disability 3.7 4.8 10.1 3.2 2.1 2.2 -0.9 -2.2 2.0
Commuting to job workplace: Cycle 0.1 0.1 0.2 0.3 -0.2 -0.4 -0.3 0.0 -0.5
Myopia 0.6 0.9 3.2 0.5 0.8 0.9 -1.8 -0.5 0.1
Vascular/heart problems diagnosed by doctor 3.3 9.0 16.9 2.6 2.5 2.8 -4.1 -2.3 3.3
Cholesterol lowering medication 0.5 0.7 1.3 -1.1 -0.8 -0.7 0.6 0.8 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.4 0.3 0.3 -0.4 -0.3 -0.1
Pain experienced in last month 2.7 4.5 7.6 -2.0 -2.4 -2.8 1.6 2.2 -1.5
Supplements: Calcium 0.2 0.2 0.4 0.5 -0.2 0.1 0.6 0.2 0.7
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.5 -0.6 0.1 0.0 0.5 -0.1
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 -0.2 0.3 -0.2 0.1 -0.1 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.5 0.1 -0.1 -0.1 0.2 -0.1 -0.7
Heart disease (siblings) 0.1 0.1 0.2 -0.5 0.4 0.4 -0.3 -0.4 0.1
Alcohol drinker status: Previous 1.0 1.1 2.0 -1.1 -1.2 -1.1 0.9 1.4 0.4
Pack years of smoking 0.3 0.4 0.8 0.0 0.8 0.9 -0.3 -0.9 0.5
Impedance of whole body 1.2 6.0 14.4 2.0 2.4 2.1 -1.4 -2.2 3.8
Leg fat mass (left) 0.8 3.1 7.9 0.3 0.8 2.0 -2.8 -0.8 2.2
Arm predicted mass (left) 0.2 1.0 2.3 -0.9 -1.2 -0.3 -0.1 1.1 -1.5