TWAS hub - GFER

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.397	0.1275	2.0e-03	-0.007	NA	-0.007	NA	-0.011	5.3e-01	NA	5.4e-01	NA	8.9e-01
2	GTEx	Testis	0.194	0.0630	3.9e-04	0.115	NA	0.080	NA	0.100	9.1e-06	NA	2.0e-04	NA	3.4e-05
3	ROSMAP	Brain Pre-frontal Cortex	0.150	0.0359	4.6e-08	0.092	0.072	0.116	0.098	0.109	6.6e-12	1.4e-09	1.2e-14	1.3e-12	6.6e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Happiness	6.0	7.3	18.6	-0.6	4.3	-1.8
Medication: Atorvastatin	5.4	6.7	9.8	-1.2	-3.1	3.0
Arm predicted mass (right)	5.0	25.6	38.9	4.4	4.3	-6.2
Arm predicted mass (left)	5.0	25.2	41.9	4.3	4.0	-6.5
Trunk fat-free mass	4.6	26.6	45.8	3.4	4.7	-6.8
Arm fat-free mass (right)	4.6	23.6	36.1	4.2	4.1	-6.0
Hand grip strength (left)	4.5	11.9	22.7	2.0	3.0	-4.8
Trunk predicted mass	4.5	25.6	44.5	3.3	4.6	-6.7
Arm fat-free mass (left)	4.4	22.1	36.2	3.9	3.8	-6.0
Alzheimer’s Disease (in father)	4.3	4.7	7.6	-2.8	-1.8	1.8
Whole body water mass	4.1	23.4	41.2	3.2	4.3	-6.4
Hand grip strength (right)	4.0	11.0	19.9	2.0	3.0	-4.5
Comparative height size at age 10	4.0	22.1	35.9	4.1	3.6	-6.0
Standing height	3.9	38.9	73.8	4.4	4.8	-8.6
Whole body fat-free mass	3.9	22.4	40.2	3.1	4.2	-6.3
Shortness of breath walking on level ground	3.8	4.5	8.2	2.0	2.9	-1.0
Supplements: Glucosamine	3.7	4.8	8.8	-3.0	0.8	2.2
Basal metabolic rate	3.7	20.6	37.5	3.4	3.6	-6.1
Forced expiratory volume in 1-second (FEV1), predicted	3.6	7.5	11.2	1.7	2.9	-3.4
Hearing difficulty/problems: Yes	3.3	5.0	10.8	-0.5	-2.0	3.3
Ovarian Cancer	3.2	4.3	10.9	-3.3	-0.8	1.1
Height	3.1	60.5	134.6	4.5	5.2	-11.6
Hearing aid user	3.0	3.4	9.4	0.2	-0.9	3.1
Number of live births	2.9	4.1	6.9	-1.2	-2.0	2.6
Comparative body size at age 10	2.9	7.9	9.2	2.8	2.6	-3.0
Migraine (self-reported)	2.9	3.5	9.2	1.1	3.0	-0.4
Mother’s age at death	2.9	3.6	8.7	-3.0	-0.1	1.5
Weight	2.7	13.0	23.8	3.8	0.8	-4.9
Leg fat-free mass (left)	2.6	13.6	26.2	2.4	3.0	-5.1
Leg predicted mass (left)	2.6	13.8	26.2	2.4	3.1	-5.1
Neuroticism score	2.6	5.3	15.6	0.4	3.9	-0.6
Leg fat-free mass (right)	2.5	13.4	25.7	2.0	3.2	-5.1
Leg predicted mass (right)	2.5	13.1	25.3	1.9	3.2	-5.0
Systolic blood pressure, automated reading	2.4	7.1	14.8	2.4	-0.9	3.8
Qualifications: CSEs or equivalent	2.4	3.2	8.6	0.6	2.9	-0.8
Health satisfaction	2.4	3.2	8.0	1.2	2.8	-0.2
Ever taken oral contraceptive pill	2.4	2.7	4.7	-1.8	-2.2	0.6
Leg pain on walking	2.3	2.9	4.7	1.7	2.2	-1.1
Financial situation satisfaction	2.3	2.9	7.3	1.0	2.7	-0.6
Ever depressed for a whole week	2.3	2.9	7.5	0.2	2.7	-1.0
Leg fat mass (left)	2.3	9.2	19.3	4.4	-0.6	-2.8
Depressed Affect (Nagel 2018)	2.2	4.6	10.7	1.8	3.3	0.1
Exposure to tobacco smoke outside home	2.2	2.9	6.3	0.9	2.5	-1.3
Family relationship satisfaction	2.2	2.7	5.7	-0.0	2.4	-1.5
Medication: Simvastatin	2.1	3.0	8.2	0.9	-2.9	-0.4
Hip circumference	2.1	9.1	14.6	3.5	-0.8	-3.8
Number of full brothers	2.1	2.7	4.8	0.7	-2.2	1.7
Leg fat mass (right)	2.1	8.1	17.9	4.2	-0.6	-2.5
Wears glasses or contact lenses	2.1	2.5	4.6	-1.2	-2.1	1.1
Systolic Blood Pressure	2.0	10.1	30.1	-0.1	0.1	5.5
Average weekly fortified wine intake	2.0	2.3	5.2	0.2	-1.3	2.3
Trunk fat mass	2.0	8.4	14.0	3.7	-1.5	-3.0
Noisy workplace	2.0	2.5	3.3	1.5	1.4	-1.8
Chronic bronchitis/emphysema (mother)	2.0	2.3	6.1	-2.5	0.0	0.9
Whole body fat mass	2.0	8.2	14.7	3.8	-1.3	-2.8
Supplements: Vitamin C	2.0	2.4	5.1	-2.3	-0.2	1.5
Miserableness	2.0	3.5	9.4	1.0	3.1	-0.4
Diastolic blood pressure, automated reading	2.0	6.2	13.3	1.5	1.7	3.6
Frequency of depressed mood in last 2 weeks	1.9	2.6	5.9	1.1	2.4	0.9
Angina	1.9	2.5	5.0	2.2	-1.5	0.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	6.4	0.4	2.5	-0.6
Pulse wave peak to peak time	1.9	2.3	3.1	1.1	1.8	-1.6
High cholesterol (Self-reported)	1.9	3.3	8.1	0.0	-2.8	1.3
Leg fat percentage (left)	1.9	6.8	15.7	4.0	-2.1	-0.7
Myopia	1.9	2.8	7.2	-1.0	2.7	-0.5
Cholesterol lowering medication	1.9	2.8	5.5	-0.4	-2.3	1.7
Depression (Nagel 2018)	1.8	2.7	5.0	1.4	2.2	1.1
Sitting height	1.8	12.6	17.5	3.1	3.2	-4.2
Leg fat percentage (right)	1.8	6.4	14.7	3.8	-2.1	-0.5
Neuroticism (Nagel 2018)	1.7	3.9	10.2	1.2	3.2	0.1
Prostate Cancer	1.7	2.3	4.7	-0.9	-1.2	2.2
Neuroticism	1.7	4.2	11.9	0.8	3.4	-0.1
Townsend deprivation index at recruitment	1.7	2.4	5.7	-0.9	-2.4	0.7
Angina (self-reported)	1.7	2.2	3.5	1.9	-1.8	0.4
Mood swings	1.7	3.0	8.6	0.6	2.9	0.2
Cardiovascular Disease	1.6	5.2	11.0	2.0	1.0	3.3
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.0	1.5	1.7	-0.1
Fed-up feelings	1.6	3.0	8.0	0.9	2.8	0.3
Stomach or abdominal pain in last month	1.6	1.9	3.4	0.7	-1.4	1.9
Falls in the last year	1.6	2.1	4.4	1.4	-2.1	0.0
Lung cancer (father)	1.6	1.9	2.7	1.6	-0.7	-1.6
Exposure to tobacco smoke at home	1.6	1.8	4.0	2.0	0.4	-1.0
Rheumatoid Arthritis	1.5	2.1	4.4	1.2	2.1	-0.6
Trunk fat percentage	1.5	5.9	8.5	2.9	-2.8	-1.2
Waist circumference	1.5	5.5	8.3	2.9	-0.6	-2.8
Fluid intelligence score	1.5	3.2	7.2	-2.7	0.9	1.2
Medication: Cholesterol lowering	1.5	2.3	6.4	0.6	-2.5	0.6
Pulse wave Arterial Stiffness index	1.5	1.8	3.1	-0.8	-1.8	1.3
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	4.9	-1.5	2.2	-0.6
Birth weight	1.5	3.2	4.2	-2.0	1.8	-1.5
Body fat percentage	1.5	6.1	9.5	3.1	-2.8	-0.9
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	4.7	-2.2	-0.2	1.0
Friendships satisfaction	1.5	1.9	4.7	0.7	2.2	-0.6
Commuting to job workplace: Walk	1.5	1.6	2.5	-1.3	-0.9	1.6
Alcohol drinker status: Previous	1.5	1.7	4.6	0.7	-0.2	2.1
Schizophrenia vs Biploar Disorder	1.4	1.8	5.4	0.0	2.3	0.0
Body Mass Index (BMI) (2010)	1.4	1.9	3.6	1.9	-0.2	-1.4
Severe depression (siblings)	1.4	1.6	3.7	-0.9	0.6	-1.9
Nervous feelings	1.4	2.6	7.3	-0.4	2.7	-0.5
Had other major operations	1.4	1.7	2.3	-1.2	1.5	1.1
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.5	-1.4	1.9	1.1
Hypertension (Self-reported)	1.4	3.8	9.4	0.8	1.2	3.1
Worry (Nagel 2018)	1.3	2.7	7.5	0.5	2.7	-0.3
Lung FVC	1.3	6.5	14.0	-1.6	-1.7	3.7
High blood pressure	1.3	3.8	8.7	0.4	1.6	2.9
Alcohol intake versus 10 years previously	1.3	2.0	2.7	1.5	1.1	-1.6
Mouth/teeth dental problems: Dentures	1.3	2.1	5.6	0.4	-2.4	0.8
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	4.7	1.7	2.2	-0.4
Reaction Time	1.2	2.3	6.2	-0.8	-0.3	2.5
Hypothyroidism (self reported)	1.2	2.8	5.0	1.9	2.2	-0.1
Taking other prescription medications	1.2	1.9	3.5	0.4	-1.4	1.9
Tense / ‘highly strung’	1.2	1.9	5.6	-0.3	2.4	0.3
High blood pressure (siblings)	1.2	1.7	3.5	-1.9	1.2	0.3
Medication: Ibuprofen	1.2	1.5	2.6	1.0	1.6	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.4	1.8	0.2	-1.0
Pulse rate, automated reading	1.2	3.8	10.1	-0.3	-1.1	3.2
Long-standing illness, disability or infirmity	1.2	1.9	4.2	0.1	-1.2	2.0
Qualifications: nursing, teaching	1.2	1.9	5.4	0.5	2.3	-0.4
Medication: Gliclazide	1.2	1.4	3.3	0.9	0.0	-1.8
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.3	-1.8	1.1	0.6
Alcohol drinker status: Never	1.2	1.4	2.6	0.0	1.6	-1.3
Basal cell carcinoma (self-reported)	1.2	1.4	2.7	-1.1	-1.7	0.5
Schizophrenia (2018)	1.1	2.4	5.8	-2.4	-0.0	1.1
Crohns Disease (2017)	1.1	2.4	3.7	1.5	1.9	-1.1
High blood pressure (mother)	1.1	1.6	2.9	-1.7	-0.8	1.1
Impedance of arm (left)	1.1	5.1	8.8	-1.5	-3.0	2.0
Blood clot in the leg (DVT)	1.1	1.4	2.2	-0.5	-1.3	1.5
Knee pain experienced in last month	1.1	1.6	2.5	-1.3	-1.6	0.8
Mineral and other dietary supplements	1.1	1.5	3.0	1.7	-1.1	-0.7
Medication: Blood pressure	1.1	2.2	6.4	-0.3	-0.2	2.5
HbA1C	1.0	1.2	3.4	1.8	0.1	-0.2
Lupus	1.0	1.6	4.6	-0.1	-0.3	2.1
Neuroticism (2016)	1.0	1.4	2.8	-1.7	1.2	-0.4
Primary Biliary Cirrhosis	1.0	1.4	2.9	1.7	0.7	-0.9
Allergy or Eczema	1.0	2.7	4.5	2.1	-0.3	-1.9
Lung FEV1/FVC ratio	1.0	5.2	8.3	2.5	1.1	-2.9
Chronotype (morning person)	1.0	2.3	3.1	0.9	1.7	-1.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.0	-1.7	0.4	-0.4
Impedance of arm (right)	1.0	4.8	7.7	-1.6	-2.8	2.0
Pulse rate	1.0	1.7	2.6	0.0	-1.6	1.6
Illnesses of mother	1.0	1.2	1.5	1.1	1.0	-1.2
Arm fat mass (right)	1.0	4.1	6.1	2.5	-1.3	-2.1
Worry too long after embarrassment	1.0	1.6	4.8	-0.0	2.2	0.3
Chest pain or discomfort	1.0	1.4	3.3	1.8	-0.7	-0.7
Back pain experienced in last month	1.0	1.5	4.0	0.6	-2.0	0.3
Illnesses of father: None of the above (group 1)	1.0	1.2	3.5	0.2	0.4	-1.9
Number of operations (self-reported)	1.0	1.6	2.6	-1.2	-0.8	1.6
Irritability	1.0	1.6	3.3	0.6	1.8	-1.1
Risk taking	1.0	1.5	1.5	1.2	-1.2	-1.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.4	-0.7	-1.1	-2.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.9	1.7	-0.9	-0.1
Medication: Co-codamol	0.9	1.1	1.6	0.9	-0.9	1.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.6	-0.4	1.3	-1.2
Arm fat percentage (right)	0.9	3.6	9.3	1.2	-3.0	0.1
Time employed in main current job	0.9	1.1	2.6	0.6	0.5	-1.6
Medication: Omeprazole	0.9	1.1	2.9	1.7	-0.4	0.6
Had major operations	0.9	1.1	1.7	1.3	-1.2	0.1
Arm fat percentage (left)	0.9	3.7	9.4	1.3	-3.1	0.3
Loneliness, isolation	0.9	1.3	3.3	0.7	1.8	0.2
Ever had bowel cancer screening	0.9	1.1	2.8	0.3	-1.7	0.7
Osteoporosis (self-reported)	0.9	1.1	1.5	-1.2	-1.2	-0.6
Arm fat mass (left)	0.9	3.6	5.7	2.4	-1.2	-1.9
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.5	0.8	-1.6	0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.6	0.2	-1.6	-0.7
Bipolar Disorder or Schizophrenia	0.8	1.9	4.1	-2.0	-0.2	1.2
HDL Cholesterol	0.8	1.3	3.3	-0.5	1.8	-0.5
Heel T-Score	0.8	6.1	7.4	-2.4	-2.3	2.7
Diabetes (father)	0.8	1.1	1.4	-1.2	0.9	-0.9
Chronic bronchitis/emphysema (father)	0.8	1.0	1.7	0.9	-1.3	0.6
Heart attack	0.8	1.1	2.8	1.7	-0.7	-0.1
Loud music exposure frequency	0.8	0.9	1.8	-0.7	1.3	-0.7
Qualifications: College or University degree	0.8	2.6	5.3	-1.4	2.3	0.6
Mean time to correctly identify matches	0.8	1.5	3.9	0.7	0.1	2.0
Heart disease (mother)	0.8	1.0	1.6	1.3	-1.1	-0.2
Suffer from ‘nerves’	0.8	1.2	3.3	0.1	1.8	-0.6
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.3	-0.5	1.1	-1.1
Intelligence (Savage-Jansen 2018)	0.7	2.3	6.2	-2.5	-0.2	0.8
Irritable Bowel Disease (IBD)	0.7	1.8	4.6	0.8	2.1	-0.3
Age at First Birth	0.7	1.1	2.0	-0.3	1.1	-1.4
Triglycerides	0.7	1.1	2.7	-0.5	-1.7	0.6
Blood Platelet Count	0.7	7.8	22.8	-0.1	-4.8	0.7
Sensitivity / hurt feelings	0.7	1.2	3.3	-0.3	1.8	-0.5
Medication for hormone replacement therapy	0.7	0.8	1.9	0.3	1.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.1	-1.8	-1.2	0.2
Multivitamins +/- minerals	0.7	0.9	1.5	-0.6	1.0	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.6	-0.9	1.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.8	-0.8	-1.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.7	-0.5	2.2	0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-1.2	0.9	0.3
Glaucoma (self-reported)	0.7	0.8	1.0	-1.0	-0.9	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.8	-1.7	-0.0	-0.1
Number of children fathered	0.7	0.8	2.1	-0.5	-1.5	-0.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.1	-1.4	1.2	-0.5
Medication: Blood pressure	0.7	1.3	1.9	1.2	-1.4	0.7
Alcohol intake frequency.	0.7	1.6	3.3	1.8	1.1	-0.4
Overall health rating	0.7	1.5	4.5	2.1	-0.3	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.5	0.2	-1.6	-0.1
Smoking status: Previous	0.7	1.1	1.4	1.2	0.8	-1.1
Average weekly red wine intake	0.7	1.1	3.0	-1.7	-0.4	-0.0
Medication for cholesterol	0.7	1.1	2.5	-0.5	0.7	-1.6
Eye problems/disorders: Glaucoma	0.7	0.9	1.3	-0.9	-1.1	0.6
Supplements: Calcium	0.7	0.8	1.3	-1.0	-1.1	0.2
Fasting Glucose	0.6	0.7	1.8	0.5	-1.4	-0.0
Smoking Status	0.6	1.4	4.0	0.5	2.0	-0.2
Number of treatments/medications taken	0.6	1.0	2.7	0.0	-0.6	1.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.1	0.4	1.0	1.0
Age when periods started (menarche)	0.6	1.3	2.4	0.9	-0.9	-1.5
Pain all over the body in last month	0.6	0.7	1.2	1.1	0.8	0.4
Diabetes (self-reported)	0.6	0.9	1.8	1.3	-0.4	0.8
Worrier / anxious feelings	0.6	1.1	2.3	0.3	1.5	0.8
Peak expiratory flow (PEF)	0.6	1.3	1.8	1.2	0.8	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.0	-0.6	-1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	0.4	-1.3	-0.2
Medication: Allopurinol	0.6	0.8	1.5	-0.9	-1.2	0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	0.4	-0.6	1.2
Illnesses of father: Heart disease	0.6	0.8	1.1	0.7	0.9	1.0
Medication: Paracetamol	0.6	0.9	1.4	0.9	-1.2	0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.2	-0.9	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.2	0.0	-1.1	1.1
Ulcerative Colitis (UC)	0.5	1.0	2.5	-0.7	1.6	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.8	0.0	1.4	0.0
LDL Cholesterol	0.5	0.9	1.9	-0.0	-1.4	0.9
Average weekly spirits intake	0.5	0.6	1.5	-0.3	1.2	0.4
Relative age of first facial hair	0.5	1.1	3.2	-1.8	0.3	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	-0.1	1.3	-0.2
Vitamin and mineral supplements	0.5	0.6	1.0	1.0	-1.0	0.0
Medication: Metformin	0.5	0.7	2.2	1.5	-0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	0.4	1.1	0.8
Body mass index (BMI)	0.5	2.1	3.9	2.0	-1.2	-1.0
Impedance of leg (left)	0.5	2.3	5.8	2.4	-1.0	0.4
Number of incorrect matches in round	0.5	0.9	1.2	-0.5	1.1	1.1
Qualifications: None of the above	0.5	1.1	1.8	1.0	-1.3	-0.6
Father’s age at death	0.5	0.6	1.1	0.2	-1.1	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	1.7	1.2	1.3	-1.3
Length of working week for main job	0.5	0.6	0.9	0.3	-0.9	-1.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	-0.4	-0.1	1.6
Number of full sisters	0.5	0.6	0.8	-0.9	0.8	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	2.6	-0.0	-0.2	1.6
Average weekly champagne plus white wine intake	0.5	0.6	0.9	-1.0	-0.6	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	-1.3	-0.2	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.0	-1.0	0.0	-0.9
Medication: Bendroflumethiazide	0.5	0.7	1.2	1.1	-0.8	0.5
Illnesses of father: High blood pressure	0.5	0.6	1.5	0.4	1.2	-0.3
Ever smoked	0.5	0.9	2.6	0.3	1.6	0.1
Heart disease (siblings)	0.5	0.6	1.6	1.3	0.3	0.4
Impedance of whole body	0.5	2.8	6.2	0.2	-2.5	1.4
Alzheimer’s Disease (in mother)	0.4	0.4	0.6	0.8	-0.3	-0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	0.3	0.7	0.9
Pack years adult smoking proportion	0.4	0.6	1.2	-0.7	1.1	0.2
Impedance of leg (right)	0.4	1.9	4.1	2.0	-1.0	0.7
Current tobacco smoking	0.4	0.6	1.2	0.6	1.1	-0.6
Past tobacco smoking	0.4	0.8	1.3	-1.1	-0.8	0.7
Alcohol usually taken with meals	0.4	0.6	0.9	-0.2	-0.9	1.0
Financial difficulties in last 2 years	0.4	0.5	1.5	1.2	0.1	0.1
Mouth/teeth dental problems	0.4	0.6	1.5	0.1	1.2	-0.6
Medication: Ramipril	0.4	0.5	1.2	1.1	-0.1	0.4
Illnesses of siblings	0.4	0.5	1.4	0.4	-1.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.5	0.4	0.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	1.5	0.9	1.2	-1.2
Asthma	0.4	0.8	1.4	-1.2	0.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	1.3	0.2	1.1	-0.1
Depression (self-reported)	0.4	0.5	0.7	-0.4	0.9	0.8
Medication: Lansoprazole	0.4	0.5	1.0	-0.4	-1.0	0.6
Breastfed as a baby	0.4	0.5	1.2	-0.3	0.5	1.1
Birth weight of first child	0.4	0.8	1.1	-1.1	0.6	1.0
Pulse wave reflection index	0.4	0.5	1.0	-0.2	0.7	-1.0
Medication: Paracetamol	0.4	0.7	1.3	0.5	-1.1	0.8
Gout (self-reported)	0.4	0.5	0.9	0.2	-0.8	-0.9
Medication: Amlodipine	0.4	0.5	0.8	0.3	-0.8	0.9
Forced vital capacity (FVC), Best measure	0.4	1.6	3.3	0.5	1.8	-1.1
Neck or shoulder pain in last month	0.4	0.5	1.6	-0.2	0.2	1.3
Age at last live birth	0.4	0.6	0.9	-0.9	-0.5	0.8
Medication: Aspirin	0.4	0.5	1.0	1.0	-0.6	0.0
Diabetes diagnosed by doctor	0.4	0.6	1.9	1.4	-0.3	0.1
Asthma (self-reported)	0.4	0.7	1.7	-1.3	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.3	1.5	-0.2	-0.1
Guilty feelings	0.4	0.6	1.2	0.2	0.8	1.1
Age started oral contraceptive pill	0.4	0.6	1.2	1.1	-0.7	0.1
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.7	1.0	-0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.0	-0.2	1.4	0.7
BMI	0.3	1.9	4.0	2.0	-0.1	-1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	0.1	1.3	0.3
Supplements: Zinc	0.3	0.3	0.8	-0.3	0.1	0.9
Diabetes (mother)	0.3	0.4	1.0	0.4	-1.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.0	-0.1	1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	0.5	-0.1	-1.4
Medication: Atenolol	0.3	0.3	0.6	0.7	0.5	-0.4
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.4	0.6	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	1.0	0.3	-0.3
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	0.3	0.7	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.4	0.8	0.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	1.2	1.0	-0.2
Headache pain in last month	0.3	0.5	1.0	0.6	1.0	-0.3
Age at first live birth	0.3	0.6	1.8	-1.3	-0.2	0.0
Medication: Seretide 50 evohaler	0.3	0.4	0.5	-0.4	0.7	0.7
Illnesses of siblings: Diabetes	0.3	0.3	0.8	0.9	0.2	0.3
Medication: Aspirin	0.3	0.4	0.7	0.9	-0.7	0.1
Smoking status: Current	0.3	0.5	1.2	0.6	1.1	-0.2
Average weekly beer plus cider intake	0.3	0.4	0.9	-0.0	-0.9	0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.9	0.5	-0.2
Unable to work because of sickness or disability	0.3	0.4	0.9	0.9	0.2	0.5
Pain experienced in last month	0.3	0.5	1.4	0.4	0.1	-1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	-0.4	-0.8	0.1
Breast Cancer	0.2	0.4	0.5	0.6	0.7	0.5
Crohns Disease (2012)	0.2	0.4	0.7	0.4	0.8	0.5
Mean Putamen Volume	0.2	0.2	0.5	0.1	0.7	0.5
Blood Red Count	0.2	1.5	2.6	1.4	1.6	0.4
Blood White Count	0.2	1.5	2.4	1.2	0.8	1.6
Waist Hip Ratio (WHR)	0.2	1.0	2.9	-0.1	1.7	-0.5
Tanning	0.2	2.4	4.6	-1.5	-2.1	-0.7
Maternal smoking around birth	0.2	0.2	0.5	-0.7	0.2	-0.3
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.1	0.7	0.6
Forced vital capacity (FVC)	0.2	0.7	1.6	0.4	1.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	-0.7	-0.8	-0.2
Allergy	0.2	0.5	1.2	0.4	-0.0	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	0.3	1.0	-0.2
Eye problems/disorders: None of the above	0.2	0.3	0.7	0.0	-0.8	0.3
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.2	0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.1	0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	0.5	0.4	0.4
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.7	-0.4	0.5
Medication: Lisinopril	0.2	0.3	0.5	0.3	0.7	0.4
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.5	-0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.0	0.5	0.0
Ulcerative Colitis	0.1	0.2	0.5	0.0	-0.7	0.0
Respiratory disease	0.1	0.2	0.4	-0.2	-0.7	0.5
Relative age voice broke	0.1	0.1	0.2	0.4	-0.4	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.4	-0.3	0.1
Had menopause	0.1	0.1	0.2	-0.3	-0.5	0.2
Prospective memory result	0.1	0.1	0.1	-0.3	0.3	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.2	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.5	0.1	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.1	0.3	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.5	0.4	0.2
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.4	0.1
Pack years of smoking	0.1	0.2	0.3	-0.5	0.5	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	-0.2	0.0
Blood Eosinophil Count	0.0	0.3	0.8	-0.1	0.9	0.4
Hair Pigment	0.0	0.4	1.0	-0.0	0.3	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.0	-0.1	0.2

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