[Hub]/) : Traits : Miserableness :

chr8:8,092,025-12,966,739

Best TWAS P=6.79e-12 · Best GWAS P=1.58e-11 conditioned to 0.00356

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ERI1 0.06 0.04 lasso 3 0.04 9.0e-06 5.6 6.0 2.7e-09 -0.45 0.80 0.20 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM167A 0.09 0.09 lasso 6 0.13 1.4e-15 3.4 5.4 5.5e-08 -0.51 0.76 0.24 FALSE
3 CommonMind Brain Pre-frontal Cortex FAM86B1 0.02 0.02 lasso 3 0.01 1.3e-02 -4.6 -5.5 4.9e-08 0.58 0.01 0.97 FALSE
4 GTEx Adipose Subcutaneous AF131215.2 0.24 0.15 lasso 7 0.14 3.5e-11 5.0 -5.3 1.4e-07 0.52 0.78 0.22 FALSE
5 GTEx Adipose Visceral Omentum FAM86B3P 0.23 0.07 enet 20 0.14 6.4e-08 -6.3 -5.8 7.0e-09 0.67 0.04 0.96 FALSE
6 GTEx Adipose Visceral Omentum AF131215.2 0.12 0.08 lasso 6 0.06 4.6e-04 -5.4 -6.0 2.7e-09 0.54 0.25 0.72 FALSE
7 GTEx Adipose Visceral Omentum AF131215.9 0.18 0.16 lasso 7 0.16 2.0e-08 -5.4 -5.8 7.5e-09 0.55 0.34 0.66 FALSE
8 GTEx Adrenal Gland AF131215.2 0.20 0.16 enet 12 0.13 2.2e-05 -5.6 -5.8 6.7e-09 0.58 0.29 0.71 FALSE
9 GTEx Adrenal Gland AF131215.9 0.18 0.16 lasso 10 0.18 3.5e-07 -5.6 -5.9 4.1e-09 0.59 0.30 0.69 FALSE
10 GTEx Artery Aorta ERI1 0.11 0.08 lasso 5 0.10 5.1e-06 -5.8 5.9 4.2e-09 -0.60 0.40 0.58 FALSE
11 GTEx Artery Aorta AF131215.2 0.09 0.09 lasso 7 0.08 2.0e-05 5.0 -5.8 5.5e-09 0.57 0.07 0.93 FALSE
12 GTEx Artery Aorta AF131215.9 0.13 0.05 lasso 6 0.07 1.3e-04 -5.5 -5.7 9.3e-09 0.56 0.35 0.63 FALSE
13 GTEx Artery Coronary AC087269.1 0.20 0.02 enet 29 0.02 8.7e-02 -6.0 5.3 1.1e-07 -0.50 0.08 0.49 FALSE
14 GTEx Artery Tibial ERI1 0.05 0.02 lasso 7 0.01 3.2e-02 -6.0 6.3 3.1e-10 -0.62 0.09 0.84 FALSE
15 GTEx Brain Cerebellar Hemisphere FAM86B3P 0.28 0.27 lasso 8 0.28 5.4e-08 -6.5 6.2 4.1e-10 -0.77 0.02 0.98 FALSE
16 GTEx Brain Cerebellar Hemisphere AF131215.2 0.15 0.17 lasso 3 0.09 3.0e-03 5.4 -5.9 3.1e-09 0.51 0.14 0.54 FALSE
17 GTEx Brain Cerebellum FAM86B3P 0.19 0.14 lasso 5 0.16 1.8e-05 -5.6 6.5 8.0e-11 -0.79 0.04 0.95 FALSE
18 GTEx Brain Cortex FAM86B3P 0.14 0.05 enet 9 0.07 5.1e-03 -6.0 6.5 7.9e-11 -0.69 0.13 0.43 FALSE
19 GTEx Brain Frontal Cortex BA9 FAM86B3P 0.16 0.13 enet 27 0.10 1.1e-03 -4.8 5.5 3.7e-08 -0.68 0.05 0.88 FALSE
20 GTEx Breast Mammary Tissue AF131215.2 0.16 0.15 lasso 6 0.12 1.1e-06 5.0 -6.0 2.6e-09 0.58 0.18 0.81 FALSE
21 GTEx Breast Mammary Tissue AF131215.9 0.10 0.10 lasso 8 0.12 8.7e-07 5.5 -6.1 1.2e-09 0.59 0.08 0.92 FALSE
22 GTEx Breast Mammary Tissue (Female) AF131215.2 0.04 -0.01 lasso 2 0.00 4.8e-01 5.5 -6.0 2.2e-09 0.52 0.06 0.29 FALSE
23 GTEx Breast Mammary Tissue (Female) AF131215.9 0.04 -0.01 enet 6 0.02 7.3e-02 4.6 -5.8 5.5e-09 0.56 0.06 0.34 FALSE
24 GTEx Cells EBV-transformed lymphocytes AF131215.2 0.20 0.10 enet 14 0.11 1.5e-04 5.4 -6.2 4.4e-10 0.54 0.33 0.60 FALSE
25 GTEx Cells EBV-transformed lymphocytes AF131215.9 0.20 0.15 enet 19 0.13 5.6e-05 5.4 -5.7 1.1e-08 0.51 0.19 0.74 FALSE
26 GTEx Cells Transformed fibroblasts ERI1 0.34 0.35 lasso 7 0.35 1.9e-27 -5.8 6.1 1.1e-09 -0.59 0.50 0.50 FALSE
27 GTEx Cells Transformed fibroblasts FAM86B3P 0.23 0.33 lasso 11 0.38 8.4e-30 -5.0 -6.0 1.7e-09 0.71 0.84 0.16 FALSE
28 GTEx Colon Sigmoid AF131215.2 0.10 0.00 enet 7 0.02 5.0e-02 -4.8 -6.2 4.6e-10 0.60 0.11 0.59 FALSE
29 GTEx Colon Sigmoid AF131215.9 0.11 0.17 enet 5 0.09 4.9e-04 5.4 -6.0 2.7e-09 0.51 0.20 0.56 FALSE
30 GTEx Colon Transverse FAM86B3P 0.13 0.04 lasso 8 0.04 4.4e-03 -5.6 -5.4 6.4e-08 0.66 0.08 0.71 FALSE
31 GTEx Colon Transverse AF131215.9 0.12 0.14 enet 18 0.12 4.0e-06 5.4 -5.8 8.3e-09 0.51 0.38 0.60 FALSE
32 GTEx Esophagus Gastroesophageal Junction AF131215.2 0.13 0.06 enet 10 0.11 6.4e-05 -5.2 -5.4 5.7e-08 0.57 0.35 0.41 FALSE
33 GTEx Esophagus Mucosa FAM86B3P 0.22 0.17 lasso 8 0.19 1.7e-12 -5.0 -5.7 1.3e-08 0.71 0.47 0.53 FALSE
34 GTEx Esophagus Mucosa AF131215.2 0.15 0.14 enet 15 0.18 4.3e-12 4.9 -5.9 4.2e-09 0.57 0.61 0.39 FALSE
35 GTEx Esophagus Mucosa AF131215.9 0.18 0.16 lasso 14 0.19 1.6e-12 -5.9 -6.1 8.6e-10 0.58 0.08 0.92 FALSE
36 GTEx Esophagus Muscularis ERI1 0.12 0.09 enet 13 0.08 7.7e-06 -5.5 6.9 6.8e-12 -0.67 0.12 0.88 TRUE
37 GTEx Esophagus Muscularis AF131215.2 0.10 0.08 lasso 5 0.09 2.3e-06 4.9 -5.3 1.2e-07 0.52 0.56 0.42 FALSE
38 GTEx Esophagus Muscularis AF131215.9 0.14 0.17 enet 16 0.17 1.6e-10 5.4 -5.8 5.9e-09 0.55 0.18 0.82 FALSE
39 GTEx Heart Atrial Appendage AF131215.2 0.39 0.13 enet 26 0.21 6.6e-10 4.9 -5.5 3.0e-08 0.54 0.11 0.89 FALSE
40 GTEx Heart Atrial Appendage AF131215.9 0.24 0.17 enet 26 0.18 1.3e-08 4.9 -5.4 5.9e-08 0.51 0.08 0.92 FALSE
41 GTEx Heart Left Ventricle AF131215.2 0.05 0.01 enet 11 0.01 1.5e-01 -5.5 -5.8 7.9e-09 0.53 0.22 0.54 FALSE
42 GTEx Heart Left Ventricle AF131215.9 0.07 0.10 enet 8 0.10 9.4e-06 5.4 -6.0 2.1e-09 0.53 0.36 0.60 FALSE
43 GTEx Lung ERI1 0.13 0.07 lasso 6 0.09 2.7e-07 5.6 6.0 1.7e-09 -0.64 0.23 0.77 FALSE
44 GTEx Lung AC087269.1 0.20 0.19 lasso 9 0.18 4.8e-14 -4.5 5.3 1.1e-07 -0.44 1.00 0.00 FALSE
45 GTEx Lung CLDN23 0.18 0.17 lasso 7 0.16 2.5e-12 -4.5 5.4 6.5e-08 -0.42 1.00 0.00 FALSE
46 GTEx Lung AF131215.2 0.12 0.08 lasso 5 0.08 1.0e-06 5.4 -5.7 1.0e-08 0.48 0.36 0.64 FALSE
47 GTEx Lung AF131215.9 0.15 0.18 lasso 4 0.15 1.5e-11 5.4 -5.6 2.8e-08 0.48 0.47 0.53 FALSE
48 GTEx Muscle Skeletal MFHAS1 0.07 0.04 lasso 4 0.04 1.4e-04 -3.8 -5.5 3.3e-08 0.62 0.17 0.81 FALSE
49 GTEx Nerve Tibial ERI1 0.07 0.01 enet 16 0.01 4.2e-02 4.9 5.5 2.9e-08 -0.63 0.22 0.42 FALSE
50 GTEx Nerve Tibial AF131215.2 0.19 0.18 lasso 12 0.23 3.5e-16 4.9 -5.9 3.1e-09 0.55 0.38 0.62 FALSE
51 GTEx Nerve Tibial AF131215.9 0.17 0.17 lasso 4 0.18 5.0e-13 5.4 -5.5 3.8e-08 0.48 0.52 0.48 FALSE
52 GTEx Pancreas ERI1 0.08 0.00 enet 16 0.04 6.6e-03 -4.5 5.2 2.5e-07 -0.54 0.17 0.25 FALSE
53 GTEx Pancreas AF131215.2 0.16 0.16 enet 17 0.15 9.1e-07 5.4 -6.1 9.3e-10 0.55 0.38 0.62 FALSE
54 GTEx Pancreas AF131215.9 0.25 0.24 enet 14 0.22 1.0e-09 -5.5 -5.7 1.0e-08 0.56 0.37 0.63 FALSE
55 GTEx Pituitary FAM86B3P 0.13 0.15 lasso 4 0.13 3.5e-04 4.4 5.2 2.2e-07 -0.65 0.04 0.85 FALSE
56 GTEx Prostate AF131215.2 0.18 0.02 lasso 6 0.02 9.6e-02 -5.6 -6.3 3.5e-10 0.54 0.07 0.59 FALSE
57 GTEx Skin Not Sun Exposed Suprapubic AF131215.2 0.16 0.11 enet 21 0.20 3.9e-11 4.9 -6.2 7.6e-10 0.55 0.39 0.61 FALSE
58 GTEx Skin Not Sun Exposed Suprapubic AF131215.9 0.17 0.14 lasso 8 0.19 9.4e-11 5.4 -5.8 5.7e-09 0.54 0.50 0.50 FALSE
59 GTEx Skin Sun Exposed Lower leg MSRA 0.10 0.02 lasso 4 0.01 8.5e-02 -3.3 5.5 5.1e-08 -0.53 0.02 0.95 FALSE
60 GTEx Skin Sun Exposed Lower leg AF131215.2 0.14 0.11 lasso 9 0.16 4.3e-13 4.9 -5.9 4.4e-09 0.51 0.74 0.26 FALSE
61 GTEx Skin Sun Exposed Lower leg AF131215.9 0.19 0.17 enet 29 0.21 3.9e-17 5.4 -6.8 1.1e-11 0.55 0.51 0.49 FALSE
62 GTEx Small Intestine Terminal Ileum AF131215.2 0.14 0.07 lasso 3 0.07 1.1e-02 4.3 -5.3 1.3e-07 0.48 0.16 0.33 FALSE
63 GTEx Small Intestine Terminal Ileum AF131215.9 0.14 0.11 enet 16 0.06 1.6e-02 4.0 -5.4 7.6e-08 0.52 0.14 0.32 FALSE
64 GTEx Spleen AF131215.2 0.16 0.08 enet 14 0.06 1.1e-02 5.4 -6.1 9.4e-10 0.55 0.15 0.64 FALSE
65 GTEx Spleen AF131215.9 0.34 0.23 enet 16 0.15 1.2e-04 -5.5 -6.0 1.9e-09 0.53 0.23 0.66 FALSE
66 GTEx Testis FAM86B3P 0.15 0.14 lasso 7 0.13 2.2e-06 -6.0 5.7 1.6e-08 -0.72 0.06 0.94 FALSE
67 GTEx Testis SGK223 0.29 0.02 enet 19 0.07 3.5e-04 -6.7 6.0 2.2e-09 -0.69 0.01 0.95 FALSE
68 GTEx Thyroid SGK223 0.19 0.35 enet 16 0.36 1.1e-28 -5.3 6.3 3.3e-10 -0.79 0.92 0.08 FALSE
69 GTEx Thyroid AF131215.2 0.11 0.15 enet 17 0.18 1.2e-13 4.9 -6.1 8.4e-10 0.54 0.64 0.36 FALSE
70 GTEx Thyroid AF131215.9 0.11 0.08 enet 16 0.17 4.7e-13 5.4 -6.4 1.8e-10 0.54 0.43 0.56 FALSE
71 GTEx Uterus AF131215.2 0.17 0.07 enet 13 0.09 7.1e-03 -5.6 -6.3 3.3e-10 0.58 0.15 0.49 FALSE
72 GTEx Uterus AF131215.9 0.16 -0.01 enet 18 0.03 7.5e-02 -5.6 -5.8 5.5e-09 0.51 0.13 0.46 FALSE
73 GTEx Vagina AF131215.2 0.20 0.14 lasso 3 0.11 1.9e-03 5.0 -5.6 2.2e-08 0.42 0.14 0.28 FALSE
74 GTEx Vagina AF131215.9 0.21 0.11 lasso 9 0.08 6.3e-03 -5.6 -6.2 7.5e-10 0.54 0.11 0.79 FALSE
75 NTR Blood MFHAS1 0.02 0.01 blup 759 0.01 2.9e-04 -6.4 -5.7 1.4e-08 0.61 0.05 0.94 FALSE
76 NTR Blood MSRA 0.02 0.01 blup 833 0.01 2.3e-05 -5.2 5.8 5.2e-09 -0.55 0.16 0.84 FALSE
77 NTR Blood PPP1R3B 0.03 0.02 enet 11 0.02 1.5e-07 -4.1 -5.2 2.6e-07 0.42 1.00 0.00 FALSE
78 ROSMAP Brain Pre-frontal Cortex MTMR9 0.07 0.06 enet 16 0.08 9.5e-11 4.6 5.4 5.4e-08 -0.55 0.98 0.02 FALSE
79 ROSMAP Brain Pre-frontal Cortex FAM167A 0.12 0.03 bslmm 620 0.08 1.3e-10 -4.3 5.9 3.1e-09 -0.50 0.10 0.90 FALSE
80 ROSMAP Brain Pre-frontal Cortex XKR6 0.11 0.10 enet 23 0.13 1.2e-16 5.2 -5.5 3.4e-08 0.57 0.08 0.92 FALSE
81 ROSMAP Brain Pre-frontal Cortex FAM86B3P 0.19 0.27 bslmm 331 0.27 5.6e-35 -6.0 5.7 1.6e-08 -0.60 0.18 0.82 FALSE
82 ROSMAP Brain Pre-frontal Cortex FAM66A 0.23 0.26 enet 29 0.30 4.7e-39 -5.1 -5.4 7.2e-08 0.57 0.00 1.00 FALSE
83 ROSMAP Brain Pre-frontal Cortex FAM85B 0.16 0.23 enet 18 0.22 1.8e-28 -4.9 5.6 1.7e-08 -0.70 0.86 0.14 FALSE
84 ROSMAP Brain Pre-frontal Cortex AF131215.3 0.08 0.10 lasso 7 0.12 8.3e-16 -5.8 -6.1 8.8e-10 0.59 0.15 0.85 FALSE
85 ROSMAP Brain Pre-frontal Cortex FAM66D 0.15 0.16 bslmm 227 0.17 5.3e-21 4.6 5.2 1.9e-07 -0.49 0.05 0.93 FALSE
86 ROSMAP Brain Pre-frontal Cortex RP11-481A20.11 0.06 0.04 blup 286 0.04 2.2e-06 -5.3 -5.5 3.6e-08 0.58 0.44 0.56 FALSE
87 ROSMAP Brain Pre-frontal Cortex AF131215.2 0.49 0.57 lasso 7 0.57 9.0e-89 5.4 -5.6 2.5e-08 0.48 0.50 0.50 FALSE
88 The Cancer Genome Atlas Bladder Urothelial Carcinoma FLJ10661 0.10 0.16 lasso 1 0.15 6.1e-13 -5.6 -5.6 1.9e-08 0.64 0.01 0.99 FALSE
89 The Cancer Genome Atlas Breast Invasive Carcinoma PPP1R3B 0.03 0.03 enet 8 0.03 1.8e-06 -5.2 5.6 2.2e-08 -0.45 0.08 0.92 FALSE
90 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FLJ10661 0.33 0.09 blup 42 0.09 3.7e-05 -5.6 -5.2 1.8e-07 0.52 0.01 0.97 FALSE
91 The Cancer Genome Atlas Colon Adenocarcinoma FLJ10661 0.15 0.26 lasso 4 0.23 3.0e-13 -5.6 -5.7 1.2e-08 0.66 0.01 0.98 FALSE
92 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FLJ10661 0.07 0.14 lasso 3 0.14 3.7e-15 -5.6 -5.6 2.5e-08 0.65 0.01 0.99 FALSE
93 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FLJ10661 0.07 0.01 lasso 4 0.03 1.6e-04 -2.8 -5.5 4.3e-08 0.49 0.03 0.47 FALSE
94 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TDH 0.05 0.01 blup 67 0.04 1.3e-05 -4.9 5.3 1.1e-07 -0.48 0.02 0.97 FALSE
95 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FLJ10661 0.07 0.02 blup 42 0.04 2.9e-03 -4.9 -5.5 3.0e-08 0.65 0.01 0.89 FALSE
96 The Cancer Genome Atlas Brain Lower Grade Glioma FLJ10661 0.21 0.26 lasso 9 0.30 2.3e-34 -4.9 5.6 1.7e-08 -0.66 0.03 0.97 FALSE
97 The Cancer Genome Atlas Lung Adenocarcinoma ERI1 0.06 0.04 blup 72 0.04 1.5e-05 -5.6 6.2 6.7e-10 -0.55 0.06 0.93 FALSE
98 The Cancer Genome Atlas Pancreatic Adenocarcinoma FAM167A 0.09 0.05 lasso 4 0.08 3.0e-04 -4.5 -5.5 3.9e-08 0.42 0.02 0.65 FALSE
99 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FLJ10661 0.25 0.18 lasso 4 0.16 4.2e-07 -4.8 5.5 3.0e-08 -0.69 0.00 1.00 FALSE
100 The Cancer Genome Atlas Stomach Adenocarcinoma FLJ10661 0.08 0.05 blup 42 0.07 9.3e-06 -4.9 -5.3 1.2e-07 0.66 0.00 1.00 FALSE
101 The Cancer Genome Atlas Testicular Germ Cell Tumors FLJ10661 0.24 0.36 enet 8 0.35 4.1e-13 -5.6 -5.4 5.4e-08 0.64 0.02 0.98 FALSE
102 The Cancer Genome Atlas Thyroid Carcinoma SGK223 0.16 0.20 enet 14 0.22 6.1e-21 4.6 5.5 3.2e-08 -0.68 0.04 0.94 FALSE