[Hub]/) : Traits : Miserableness : ← →

chr8:8,092,025-12,966,739

Best TWAS P=6.79e-12 · Best GWAS P=1.58e-11 conditioned to 0.00356

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
36	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	-5.5	6.9	6.8e-12	-0.67	0.12	0.88	TRUE
61	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	5.4	-6.8	1.1e-11	0.55	0.51	0.49	FALSE
18	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-6.0	6.5	7.9e-11	-0.69	0.13	0.43	FALSE
17	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	-5.6	6.5	8.0e-11	-0.79	0.04	0.95	FALSE
70	GTEx	Thyroid	AF131215.9	0.11	0.08	enet	16	0.17	4.7e-13	5.4	-6.4	1.8e-10	0.54	0.43	0.56	FALSE
14	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	-6.0	6.3	3.1e-10	-0.62	0.09	0.84	FALSE
68	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	-5.3	6.3	3.3e-10	-0.79	0.92	0.08	FALSE
71	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	-5.6	-6.3	3.3e-10	0.58	0.15	0.49	FALSE
56	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	-5.6	-6.3	3.5e-10	0.54	0.07	0.59	FALSE
15	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-6.5	6.2	4.1e-10	-0.77	0.02	0.98	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	AF131215.2	0.20	0.10	enet	14	0.11	1.5e-04	5.4	-6.2	4.4e-10	0.54	0.33	0.60	FALSE
28	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	-4.8	-6.2	4.6e-10	0.60	0.11	0.59	FALSE
97	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	-5.6	6.2	6.7e-10	-0.55	0.06	0.93	FALSE
74	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	-5.6	-6.2	7.5e-10	0.54	0.11	0.79	FALSE
57	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	4.9	-6.2	7.6e-10	0.55	0.39	0.61	FALSE
69	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	4.9	-6.1	8.4e-10	0.54	0.64	0.36	FALSE
35	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	-5.9	-6.1	8.6e-10	0.58	0.08	0.92	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	-5.8	-6.1	8.8e-10	0.59	0.15	0.85	FALSE
53	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	5.4	-6.1	9.3e-10	0.55	0.38	0.62	FALSE
64	GTEx	Spleen	AF131215.2	0.16	0.08	enet	14	0.06	1.1e-02	5.4	-6.1	9.4e-10	0.55	0.15	0.64	FALSE
26	GTEx	Cells Transformed fibroblasts	ERI1	0.34	0.35	lasso	7	0.35	1.9e-27	-5.8	6.1	1.1e-09	-0.59	0.50	0.50	FALSE
21	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	5.5	-6.1	1.2e-09	0.59	0.08	0.92	FALSE
27	GTEx	Cells Transformed fibroblasts	FAM86B3P	0.23	0.33	lasso	11	0.38	8.4e-30	-5.0	-6.0	1.7e-09	0.71	0.84	0.16	FALSE
43	GTEx	Lung	ERI1	0.13	0.07	lasso	6	0.09	2.7e-07	5.6	6.0	1.7e-09	-0.64	0.23	0.77	FALSE
65	GTEx	Spleen	AF131215.9	0.34	0.23	enet	16	0.15	1.2e-04	-5.5	-6.0	1.9e-09	0.53	0.23	0.66	FALSE
42	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	5.4	-6.0	2.1e-09	0.53	0.36	0.60	FALSE
22	GTEx	Breast Mammary Tissue (Female)	AF131215.2	0.04	-0.01	lasso	2	0.00	4.8e-01	5.5	-6.0	2.2e-09	0.52	0.06	0.29	FALSE
67	GTEx	Testis	SGK223	0.29	0.02	enet	19	0.07	3.5e-04	-6.7	6.0	2.2e-09	-0.69	0.01	0.95	FALSE
20	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	5.0	-6.0	2.6e-09	0.58	0.18	0.81	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ERI1	0.06	0.04	lasso	3	0.04	9.0e-06	5.6	6.0	2.7e-09	-0.45	0.80	0.20	FALSE
6	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	-5.4	-6.0	2.7e-09	0.54	0.25	0.72	FALSE
29	GTEx	Colon Sigmoid	AF131215.9	0.11	0.17	enet	5	0.09	4.9e-04	5.4	-6.0	2.7e-09	0.51	0.20	0.56	FALSE
16	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	5.4	-5.9	3.1e-09	0.51	0.14	0.54	FALSE
50	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	4.9	-5.9	3.1e-09	0.55	0.38	0.62	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	FAM167A	0.12	0.03	bslmm	620	0.08	1.3e-10	-4.3	5.9	3.1e-09	-0.50	0.10	0.90	FALSE
9	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	-5.6	-5.9	4.1e-09	0.59	0.30	0.69	FALSE
10	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	-5.8	5.9	4.2e-09	-0.60	0.40	0.58	FALSE
34	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	4.9	-5.9	4.2e-09	0.57	0.61	0.39	FALSE
60	GTEx	Skin Sun Exposed Lower leg	AF131215.2	0.14	0.11	lasso	9	0.16	4.3e-13	4.9	-5.9	4.4e-09	0.51	0.74	0.26	FALSE
76	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	-5.2	5.8	5.2e-09	-0.55	0.16	0.84	FALSE
11	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	5.0	-5.8	5.5e-09	0.57	0.07	0.93	FALSE
23	GTEx	Breast Mammary Tissue (Female)	AF131215.9	0.04	-0.01	enet	6	0.02	7.3e-02	4.6	-5.8	5.5e-09	0.56	0.06	0.34	FALSE
72	GTEx	Uterus	AF131215.9	0.16	-0.01	enet	18	0.03	7.5e-02	-5.6	-5.8	5.5e-09	0.51	0.13	0.46	FALSE
58	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.9	0.17	0.14	lasso	8	0.19	9.4e-11	5.4	-5.8	5.7e-09	0.54	0.50	0.50	FALSE
38	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	5.4	-5.8	5.9e-09	0.55	0.18	0.82	FALSE
8	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	-5.6	-5.8	6.7e-09	0.58	0.29	0.71	FALSE
5	GTEx	Adipose Visceral Omentum	FAM86B3P	0.23	0.07	enet	20	0.14	6.4e-08	-6.3	-5.8	7.0e-09	0.67	0.04	0.96	FALSE
7	GTEx	Adipose Visceral Omentum	AF131215.9	0.18	0.16	lasso	7	0.16	2.0e-08	-5.4	-5.8	7.5e-09	0.55	0.34	0.66	FALSE
41	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	-5.5	-5.8	7.9e-09	0.53	0.22	0.54	FALSE
31	GTEx	Colon Transverse	AF131215.9	0.12	0.14	enet	18	0.12	4.0e-06	5.4	-5.8	8.3e-09	0.51	0.38	0.60	FALSE
12	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	-5.5	-5.7	9.3e-09	0.56	0.35	0.63	FALSE
46	GTEx	Lung	AF131215.2	0.12	0.08	lasso	5	0.08	1.0e-06	5.4	-5.7	1.0e-08	0.48	0.36	0.64	FALSE
54	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	-5.5	-5.7	1.0e-08	0.56	0.37	0.63	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	AF131215.9	0.20	0.15	enet	19	0.13	5.6e-05	5.4	-5.7	1.1e-08	0.51	0.19	0.74	FALSE
91	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ10661	0.15	0.26	lasso	4	0.23	3.0e-13	-5.6	-5.7	1.2e-08	0.66	0.01	0.98	FALSE
33	GTEx	Esophagus Mucosa	FAM86B3P	0.22	0.17	lasso	8	0.19	1.7e-12	-5.0	-5.7	1.3e-08	0.71	0.47	0.53	FALSE
75	NTR	Blood	MFHAS1	0.02	0.01	blup	759	0.01	2.9e-04	-6.4	-5.7	1.4e-08	0.61	0.05	0.94	FALSE
66	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	-6.0	5.7	1.6e-08	-0.72	0.06	0.94	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	FAM86B3P	0.19	0.27	bslmm	331	0.27	5.6e-35	-6.0	5.7	1.6e-08	-0.60	0.18	0.82	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	-4.9	5.6	1.7e-08	-0.70	0.86	0.14	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	-4.9	5.6	1.7e-08	-0.66	0.03	0.97	FALSE
88	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ10661	0.10	0.16	lasso	1	0.15	6.1e-13	-5.6	-5.6	1.9e-08	0.64	0.01	0.99	FALSE
73	GTEx	Vagina	AF131215.2	0.20	0.14	lasso	3	0.11	1.9e-03	5.0	-5.6	2.2e-08	0.42	0.14	0.28	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP1R3B	0.03	0.03	enet	8	0.03	1.8e-06	-5.2	5.6	2.2e-08	-0.45	0.08	0.92	FALSE
87	ROSMAP	Brain Pre-frontal Cortex	AF131215.2	0.49	0.57	lasso	7	0.57	9.0e-89	5.4	-5.6	2.5e-08	0.48	0.50	0.50	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ10661	0.07	0.14	lasso	3	0.14	3.7e-15	-5.6	-5.6	2.5e-08	0.65	0.01	0.99	FALSE
47	GTEx	Lung	AF131215.9	0.15	0.18	lasso	4	0.15	1.5e-11	5.4	-5.6	2.8e-08	0.48	0.47	0.53	FALSE
49	GTEx	Nerve Tibial	ERI1	0.07	0.01	enet	16	0.01	4.2e-02	4.9	5.5	2.9e-08	-0.63	0.22	0.42	FALSE
39	GTEx	Heart Atrial Appendage	AF131215.2	0.39	0.13	enet	26	0.21	6.6e-10	4.9	-5.5	3.0e-08	0.54	0.11	0.89	FALSE
95	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ10661	0.07	0.02	blup	42	0.04	2.9e-03	-4.9	-5.5	3.0e-08	0.65	0.01	0.89	FALSE
99	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ10661	0.25	0.18	lasso	4	0.16	4.2e-07	-4.8	5.5	3.0e-08	-0.69	0.00	1.00	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	4.6	5.5	3.2e-08	-0.68	0.04	0.94	FALSE
48	GTEx	Muscle Skeletal	MFHAS1	0.07	0.04	lasso	4	0.04	1.4e-04	-3.8	-5.5	3.3e-08	0.62	0.17	0.81	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	5.2	-5.5	3.4e-08	0.57	0.08	0.92	FALSE
86	ROSMAP	Brain Pre-frontal Cortex	RP11-481A20.11	0.06	0.04	blup	286	0.04	2.2e-06	-5.3	-5.5	3.6e-08	0.58	0.44	0.56	FALSE
19	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	-4.8	5.5	3.7e-08	-0.68	0.05	0.88	FALSE
51	GTEx	Nerve Tibial	AF131215.9	0.17	0.17	lasso	4	0.18	5.0e-13	5.4	-5.5	3.8e-08	0.48	0.52	0.48	FALSE
98	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM167A	0.09	0.05	lasso	4	0.08	3.0e-04	-4.5	-5.5	3.9e-08	0.42	0.02	0.65	FALSE
93	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ10661	0.07	0.01	lasso	4	0.03	1.6e-04	-2.8	-5.5	4.3e-08	0.49	0.03	0.47	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM86B1	0.02	0.02	lasso	3	0.01	1.3e-02	-4.6	-5.5	4.9e-08	0.58	0.01	0.97	FALSE
59	GTEx	Skin Sun Exposed Lower leg	MSRA	0.10	0.02	lasso	4	0.01	8.5e-02	-3.3	5.5	5.1e-08	-0.53	0.02	0.95	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	MTMR9	0.07	0.06	enet	16	0.08	9.5e-11	4.6	5.4	5.4e-08	-0.55	0.98	0.02	FALSE
101	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ10661	0.24	0.36	enet	8	0.35	4.1e-13	-5.6	-5.4	5.4e-08	0.64	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM167A	0.09	0.09	lasso	6	0.13	1.4e-15	3.4	5.4	5.5e-08	-0.51	0.76	0.24	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	AF131215.2	0.13	0.06	enet	10	0.11	6.4e-05	-5.2	-5.4	5.7e-08	0.57	0.35	0.41	FALSE
40	GTEx	Heart Atrial Appendage	AF131215.9	0.24	0.17	enet	26	0.18	1.3e-08	4.9	-5.4	5.9e-08	0.51	0.08	0.92	FALSE
30	GTEx	Colon Transverse	FAM86B3P	0.13	0.04	lasso	8	0.04	4.4e-03	-5.6	-5.4	6.4e-08	0.66	0.08	0.71	FALSE
45	GTEx	Lung	CLDN23	0.18	0.17	lasso	7	0.16	2.5e-12	-4.5	5.4	6.5e-08	-0.42	1.00	0.00	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	-5.1	-5.4	7.2e-08	0.57	0.00	1.00	FALSE
63	GTEx	Small Intestine Terminal Ileum	AF131215.9	0.14	0.11	enet	16	0.06	1.6e-02	4.0	-5.4	7.6e-08	0.52	0.14	0.32	FALSE
13	GTEx	Artery Coronary	AC087269.1	0.20	0.02	enet	29	0.02	8.7e-02	-6.0	5.3	1.1e-07	-0.50	0.08	0.49	FALSE
44	GTEx	Lung	AC087269.1	0.20	0.19	lasso	9	0.18	4.8e-14	-4.5	5.3	1.1e-07	-0.44	1.00	0.00	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TDH	0.05	0.01	blup	67	0.04	1.3e-05	-4.9	5.3	1.1e-07	-0.48	0.02	0.97	FALSE
37	GTEx	Esophagus Muscularis	AF131215.2	0.10	0.08	lasso	5	0.09	2.3e-06	4.9	-5.3	1.2e-07	0.52	0.56	0.42	FALSE
100	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ10661	0.08	0.05	blup	42	0.07	9.3e-06	-4.9	-5.3	1.2e-07	0.66	0.00	1.00	FALSE
62	GTEx	Small Intestine Terminal Ileum	AF131215.2	0.14	0.07	lasso	3	0.07	1.1e-02	4.3	-5.3	1.3e-07	0.48	0.16	0.33	FALSE
4	GTEx	Adipose Subcutaneous	AF131215.2	0.24	0.15	lasso	7	0.14	3.5e-11	5.0	-5.3	1.4e-07	0.52	0.78	0.22	FALSE
90	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ10661	0.33	0.09	blup	42	0.09	3.7e-05	-5.6	-5.2	1.8e-07	0.52	0.01	0.97	FALSE
85	ROSMAP	Brain Pre-frontal Cortex	FAM66D	0.15	0.16	bslmm	227	0.17	5.3e-21	4.6	5.2	1.9e-07	-0.49	0.05	0.93	FALSE
55	GTEx	Pituitary	FAM86B3P	0.13	0.15	lasso	4	0.13	3.5e-04	4.4	5.2	2.2e-07	-0.65	0.04	0.85	FALSE
52	GTEx	Pancreas	ERI1	0.08	0.00	enet	16	0.04	6.6e-03	-4.5	5.2	2.5e-07	-0.54	0.17	0.25	FALSE
77	NTR	Blood	PPP1R3B	0.03	0.02	enet	11	0.02	1.5e-07	-4.1	-5.2	2.6e-07	0.42	1.00	0.00	FALSE