TWAS hub - FAM66D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.308	0.0520	0.0e+00	0.301	0.222	0.280	0.292	0.296	3.7e-37	1.5e-26	3.6e-34	6.7e-36	2.0e-36
2	ROSMAP	Brain Pre-frontal Cortex	0.145	0.0356	1.1e-16	0.165	0.144	0.157	0.168	0.166	1.1e-20	4.3e-18	1.0e-19	5.3e-21	9.4e-21

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Neuroticism (2016)	23.0	33.2	37.8	5.3	6.2
Heel bone mineral density (BMD) T-score, automated (right)	18.7	42.8	50.8	-5.9	-7.1
Heel bone mineral density (BMD) T-score, automated (left)	18.3	41.4	49.5	-5.8	-7.0
Worrier / anxious feelings	17.9	33.8	39.8	5.3	6.3
Irritability	16.3	27.5	32.6	4.7	5.7
Neuroticism score	16.0	33.3	38.8	5.3	6.2
Miserableness	14.4	24.9	27.1	4.8	5.2
Impedance of arm (right)	12.2	56.8	65.9	6.9	8.1
Impedance of whole body	10.5	53.3	64.3	6.5	8.0
Impedance of arm (left)	10.3	47.6	56.4	6.2	7.5
Nervous feelings	9.8	18.2	21.1	3.9	4.6
Lupus	9.5	14.3	17.3	-3.4	-4.2
Peak expiratory flow (PEF)	9.5	21.9	26.4	4.2	5.1
Impedance of leg (left)	9.1	44.3	54.3	5.9	7.4
Worry too long after embarrassment	8.8	14.8	17.4	3.5	4.2
Impedance of leg (right)	8.6	41.8	50.5	5.8	7.1
Suffer from ‘nerves’	8.5	13.3	14.7	3.5	3.8
Tense / ‘highly strung’	8.2	13.6	15.3	3.5	3.9
Diastolic blood pressure, automated reading	8.1	25.1	31.5	-4.3	-5.6
Hypothyroidism/myxoedema (self-reported)	7.9	15.4	19.9	3.3	4.5
Mouth/teeth dental problems: Dentures	7.8	13.1	13.7	-3.5	-3.7
Fed-up feelings	7.7	14.0	15.4	3.5	3.9
Guilty feelings	7.3	11.0	13.5	2.9	3.7
Comparative body size at age 10	7.1	19.5	23.8	-3.9	-4.9
Mood swings	7.0	12.7	14.8	3.2	3.8
Frequency of depressed mood in last 2 weeks	6.7	9.3	10.6	2.8	3.3
Ever had stillbirth, spontaneous miscarriage or termination	6.7	7.2	7.3	-2.7	-2.7
Deep venous thrombosis (DVT) (self-reported)	6.7	8.6	9.9	-2.7	-3.2
Systolic blood pressure, automated reading	6.2	17.9	24.0	-3.4	-4.9
Blood clot in the leg (DVT)	6.0	7.7	8.8	-2.6	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	5.7	18.1	19.2	4.1	4.4
Emphysema/chronic bronchitis	5.7	6.4	8.0	-2.2	-2.8
Triglycerides	5.6	9.1	13.7	2.1	3.7
Forced expiratory volume in 1-second (FEV1)	5.6	18.8	22.7	3.9	4.8
Body mass index (BMI)	5.4	23.0	30.3	-4.0	-5.5
Medication: Aspirin	5.3	7.0	7.4	-2.7	-2.6
High blood pressure	5.2	14.5	19.3	-3.1	-4.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.2	10.9	13.0	3.0	3.6
Current tobacco smoking	5.1	8.3	11.2	-2.3	-3.3
Average weekly beer plus cider intake	5.1	7.4	8.8	2.5	3.0
Mouth/teeth dental problems: Bleeding gums	5.0	6.5	7.3	-2.4	-2.7
Father’s age at death	4.8	6.4	7.0	2.4	2.6
Age at last live birth	4.8	6.9	9.1	2.2	3.0
Smoking status: Current	4.8	7.6	10.8	-2.1	-3.3
Medication for hormone replacement therapy	4.7	5.2	5.6	-2.4	-2.2
Hypertension (Self-reported)	4.6	12.9	18.0	-2.8	-4.2
Medication: Aspirin	4.6	6.0	6.2	-2.5	-2.4
Ever had hysterectomy (womb removed)	4.5	5.1	5.2	-2.2	-2.3
Medication: Levothyroxine sodium	4.5	7.6	10.5	2.2	3.2
Number of children fathered	4.5	5.1	5.5	-2.2	-2.3
Qualifications: A levels/AS levels or equivalent	4.4	9.8	13.0	2.6	3.6
Supplements: Vitamin C	4.3	5.1	5.3	-2.2	-2.3
Average weekly fortified wine intake	4.1	4.8	4.9	2.1	2.2
Mouth/teeth dental problems	4.1	6.3	6.4	2.5	2.5
Osteoarthritis (self-reported)	4.0	5.1	5.2	-2.3	-2.3
Medication: Blood pressure	4.0	7.6	10.6	-2.2	-3.3
Arm predicted mass (right)	3.9	19.8	23.3	-4.0	-4.8
Sensitivity / hurt feelings	3.8	6.5	7.4	2.4	2.7
Arm fat-free mass (right)	3.8	19.6	22.3	-4.1	-4.7
Arm fat-free mass (left)	3.8	19.3	22.4	-4.0	-4.7
Number of full sisters	3.7	4.5	5.6	-1.8	-2.4
Eye problems/disorders: Glaucoma	3.7	4.3	4.6	-2.1	-2.0
Arm predicted mass (left)	3.7	18.9	22.1	-4.0	-4.7
Family relationship satisfaction	3.6	4.4	4.7	2.2	2.0
Medication: Bendroflumethiazide	3.6	5.4	8.4	-1.6	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.3	5.4	2.3	2.3
Age at first live birth	3.5	6.2	7.9	2.1	2.8
Pulse wave peak to peak time	3.5	4.1	4.4	2.0	2.1
Medication: Blood pressure	3.5	6.2	7.7	-2.1	-2.8
Commuting to job workplace: Public transport	3.5	4.1	4.3	2.0	2.1
Vascular/heart problems diagnosed by doctor	3.5	9.6	13.6	2.4	3.7
Stomach or abdominal pain in last month	3.4	4.2	5.7	1.7	2.4
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	4.9	1.7	2.2
Mean Putamen Volume	3.3	3.7	4.0	-1.9	-2.0
Average weekly spirits intake	3.3	4.1	4.6	1.9	2.1
Knee pain experienced in last month	3.3	5.1	5.3	-2.3	-2.2
Risk taking	3.3	4.8	5.0	-2.1	-2.2
Arm fat mass (right)	3.1	12.8	17.3	-2.9	-4.2
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	6.9	1.8	2.6
Overall health rating	3.1	6.6	8.0	-2.3	-2.8
Pack years adult smoking proportion	3.0	4.6	4.8	-2.1	-2.2
Alcohol usually taken with meals	3.0	4.9	5.3	-2.1	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	3.0	3.6	3.9	1.8	2.0
Mineral and other dietary supplements	3.0	4.0	5.6	1.6	2.4
Arm fat mass (left)	3.0	12.1	16.5	-2.8	-4.1
Leg fat-free mass (left)	2.9	15.2	18.6	-3.4	-4.3
Leg predicted mass (left)	2.9	15.6	19.0	-3.5	-4.4
Length of working week for main job	2.9	3.2	4.2	-2.0	-1.5
Whole body fat-free mass	2.9	16.4	18.7	-3.8	-4.3
Whole body water mass	2.9	16.5	18.7	-3.8	-4.3
Leg fat-free mass (right)	2.8	15.0	18.0	-3.5	-4.2
Leg predicted mass (right)	2.8	14.8	17.8	-3.5	-4.2
Basal metabolic rate	2.8	15.6	18.4	-3.6	-4.3
Mouth/teeth dental problems: Mouth ulcers	2.7	4.2	5.5	1.7	2.4
Age at First Birth	2.5	3.6	4.0	1.8	2.0
Primary Biliary Cirrhosis	2.5	3.5	4.5	-1.6	-2.1
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	4.2	-2.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	4.6	1.9	2.2
Asthma	2.5	4.9	5.9	-2.0	-2.4
Pulse wave Arterial Stiffness index	2.5	2.9	2.9	-1.7	-1.7
Trunk predicted mass	2.5	14.0	15.4	-3.6	-3.9
Headache pain in last month	2.5	4.3	5.1	1.9	2.2
Leg fat mass (left)	2.5	9.8	13.9	-2.4	-3.7
Alzheimer’s Disease (in father)	2.4	2.6	2.8	1.7	1.6
Body Mass Index (BMI) (2010)	2.4	3.3	4.5	-1.4	-2.1
Medication: Atenolol	2.4	3.0	3.6	-1.6	-1.9
Trunk fat-free mass	2.4	14.0	15.3	-3.6	-3.9
Glaucoma (self-reported)	2.4	2.8	2.9	-1.7	-1.6
Medication for cholesterol	2.4	3.7	4.5	1.7	2.1
Asthma (self-reported)	2.4	4.8	6.0	-1.9	-2.5
Pain type(s) experienced in last month: Hip pain	2.4	3.0	3.1	-1.7	-1.8
Prostate Cancer	2.3	3.2	4.3	-1.5	-2.1
Ever used hormone-replacement therapy (HRT)	2.3	2.9	3.3	-1.6	-1.8
Allergy	2.3	5.3	6.0	2.2	2.4
Medication: Paracetamol	2.3	3.9	4.3	2.1	1.9
Medication: Ramipril	2.2	2.9	3.6	-1.5	-1.9
Time employed in main current job	2.2	2.5	3.1	1.4	1.8
Leg fat mass (right)	2.2	8.5	12.5	-2.2	-3.5
Supplements: Fish oil (including cod liver oil)	2.2	2.9	4.5	-1.1	-2.1
Pack years of smoking	2.2	3.2	3.3	-1.8	-1.7
Vitamin and mineral supplements	2.1	2.9	3.0	1.7	1.7
Medication: Simvastatin	2.1	3.1	3.3	-1.7	-1.8
Hip circumference	2.1	9.0	12.0	-2.5	-3.5
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	3.9	1.7	2.0
Wheeze or whistling in the chest in last year	2.1	3.7	5.7	-1.3	-2.4
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	2.7	-1.6	-1.7
Myopia	2.1	3.1	3.6	1.9	1.6
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	2.4	-1.4	-1.5
Qualifications: CSEs or equivalent	2.0	2.6	2.6	1.6	1.6
Weight	2.0	10.0	13.2	-2.6	-3.6
Forced vital capacity (FVC), Best measure	2.0	7.2	7.3	2.7	2.7
Type 2 Diabetes (T2D) (2012)	1.9	2.2	2.3	-1.5	-1.5
Birth weight of first child	1.9	3.5	5.3	1.3	2.3
Depression (Nagel 2018)	1.8	2.8	2.8	1.6	1.7
Osteoporosis (self-reported)	1.8	2.3	2.8	1.3	1.7
Serious illness, injury or assault to yourself	1.7	2.1	2.6	1.2	1.6
Ever depressed for a whole week	1.7	2.1	2.2	1.5	1.5
Schizophrenia (2014)	1.6	3.6	4.7	-1.6	-2.2
Exposure to tobacco smoke outside home	1.6	2.1	2.3	1.4	1.5
Number of full brothers	1.6	2.0	2.8	-1.1	-1.7
Chest pain or discomfort	1.6	2.3	2.6	1.4	1.6
Arm fat percentage (left)	1.6	6.3	9.4	-1.8	-3.1
Medication: Paracetamol	1.6	2.5	2.9	1.7	1.4
Medication: Lisinopril	1.6	2.1	2.9	-1.1	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	2.4	1.2	1.6
Sitting height	1.5	10.6	12.9	-2.9	-3.6
Fluid intelligence score	1.5	3.1	4.4	1.4	2.1
Pulse wave reflection index	1.5	1.9	2.4	-1.2	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.9	0.9	1.7
Medication: Gliclazide	1.5	1.7	1.9	-1.2	-1.4
Number of operations (self-reported)	1.5	2.3	2.7	-1.4	-1.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	2.6	1.3	1.6
Arm fat percentage (right)	1.4	5.4	8.1	-1.6	-2.8
Eye problems/disorders: None of the above	1.4	1.6	2.2	1.5	1.0
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.4	-1.0	-1.5
Medication: Ibuprofen	1.4	1.7	1.8	1.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	3.4	1.5	1.8
Major Depression (MDD)	1.3	1.6	2.1	1.0	1.5
High blood pressure (mother)	1.3	1.8	2.4	-1.1	-1.6
Forced vital capacity (FVC)	1.3	5.1	6.6	1.9	2.6
Illnesses of siblings	1.3	1.9	2.1	1.4	1.3
Leg pain on walking	1.3	1.6	2.6	-0.8	-1.6
Illnesses of father: None of the above (group 1)	1.3	1.6	2.4	0.9	1.6
Past tobacco smoking	1.2	2.3	2.7	1.4	1.6
Falls in the last year	1.2	1.6	1.9	-1.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	1.8	1.2	1.3
Whole body fat mass	1.2	5.2	7.7	-1.6	-2.8
Pulse rate, automated reading	1.2	3.8	4.5	-2.1	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	1.7	-1.0	-1.3
Wears glasses or contact lenses	1.2	1.4	1.5	1.2	1.1
Crohns Disease (2017)	1.1	2.4	2.5	-1.5	-1.6
Ulcerative Colitis	1.1	1.6	2.7	0.7	1.6
Medication: Amlodipine	1.1	1.6	2.3	-0.9	-1.5
Leg fat percentage (left)	1.1	3.9	6.1	-1.3	-2.5
Medication: Cholesterol lowering	1.0	1.5	1.8	-1.3	-1.1
Shortness of breath walking on level ground	1.0	1.2	1.7	-0.9	-1.3
Illnesses of father: Heart disease	1.0	1.3	1.4	-1.2	-1.1
Commuting to job workplace: Walk	1.0	1.0	1.1	-1.1	-1.0
Basal cell carcinoma (self-reported)	1.0	1.2	1.5	-1.2	-1.0
Bipolar Disorder or Schizophrenia	0.9	2.3	3.2	-1.2	-1.8
Alzheimer’s Disease (including proxy)	0.9	1.4	1.7	1.0	1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.1	1.1	1.8
Lung FEV1/FVC ratio	0.9	4.7	5.4	2.3	2.0
Standing height	0.9	9.0	12.4	2.4	3.5
High blood pressure (siblings)	0.9	1.3	1.4	-1.1	-1.2
Medication: Allopurinol	0.9	1.2	1.3	-1.0	-1.2
Diabetes (father)	0.8	1.0	2.0	-0.1	-1.4
Leg fat percentage (right)	0.8	3.0	5.1	-1.0	-2.3
Breast cancer (self-reported)	0.8	0.9	1.2	-1.1	-0.8
Commuting to job workplace: Cycle	0.8	1.0	1.0	-1.0	-1.0
Depressed Affect (Nagel 2018)	0.7	1.4	1.8	1.3	1.0
Schizophrenia (2018)	0.7	1.5	2.3	-0.8	-1.5
Crohns Disease (2012)	0.7	1.2	1.4	-1.2	-1.0
Multivitamins +/- minerals	0.7	1.0	1.0	-1.0	-1.0
Trunk fat mass	0.7	2.9	4.3	-1.3	-2.1
Had menopause	0.7	0.9	1.6	-0.5	-1.3
Health satisfaction	0.7	0.9	1.3	-0.7	-1.1
Medication for pain relief, constipation, heartburn	0.7	1.2	1.3	-1.1	-1.1
Angina (self-reported)	0.7	0.9	1.0	-0.9	-1.0
Mother’s age at death	0.7	0.9	1.0	0.9	1.0
Angina	0.6	0.8	0.9	-0.9	-0.9
Severe depression (siblings)	0.6	0.7	1.0	-0.6	-1.0
Had other major operations	0.6	0.8	0.9	-0.8	-1.0
Hair/balding pattern: Pattern 3	0.6	0.8	1.1	-0.7	-1.1
Illnesses of mother	0.6	0.8	0.9	0.9	0.8
High cholesterol (Self-reported)	0.6	1.1	1.2	-1.1	-1.0
Ever smoked	0.6	1.1	1.3	-1.1	-1.0
Heart disease (siblings)	0.6	0.7	1.3	-1.1	-0.4
Bipolar Disorder (2018)	0.5	0.8	1.0	-0.8	-1.0
Rheumatoid Arthritis	0.5	0.7	1.0	1.0	0.5
Height	0.5	9.0	9.9	-3.1	-2.9
Systolic Blood Pressure	0.5	2.4	3.9	2.0	1.0
Diabetes (mother)	0.5	0.7	0.9	0.9	0.7
Body fat percentage	0.5	1.8	3.0	-0.7	-1.7
Had major operations	0.5	0.6	1.0	1.0	0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	-0.2	-1.0
Bipolar Disorder (2011)	0.4	0.4	0.4	-0.6	-0.7
Coronary Artery Disease (CAD)	0.4	0.5	0.6	0.8	0.5
Number of treatments/medications taken	0.4	0.8	0.9	-0.8	-0.9
Medication: Metformin	0.4	0.6	1.1	-0.4	-1.0
Age when periods started (menarche)	0.4	1.0	1.8	0.3	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	0.9	-0.9	-0.9
Pain all over the body in last month	0.4	0.4	0.6	-0.5	-0.8
Diabetes (self-reported)	0.4	0.7	1.0	-0.5	-1.0
Number of live births	0.4	0.6	1.1	1.1	0.4
Prospective memory result	0.4	0.5	0.7	-0.6	-0.8
Lung cancer (father)	0.4	0.4	0.6	0.8	0.5
Hair/balding pattern: Pattern 4	0.4	1.0	1.0	1.0	1.0
Birth weight	0.4	0.8	1.2	-1.1	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.6	-0.8	-0.5
Medication: Seretide 50 evohaler	0.4	0.4	0.4	-0.6	-0.7
Heart disease (mother)	0.4	0.5	0.5	-0.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.6	0.8	0.5
Long-standing illness, disability or infirmity	0.4	0.6	0.9	-0.6	-0.9
Unable to work because of sickness or disability	0.4	0.5	0.9	-0.4	-1.0
Reaction Time	0.3	0.6	0.7	0.7	0.8
Breast Cancer	0.3	0.6	1.0	-0.5	-1.0
LDL Cholesterol	0.3	0.5	0.9	0.9	0.4
Blood White Count	0.3	1.9	2.1	1.3	1.4
Lung FVC	0.3	1.4	1.7	1.3	1.1
Number of incorrect matches in round	0.3	0.5	0.8	-0.9	-0.4
Pulse rate	0.3	0.6	1.1	-1.1	-0.1
Medication: Lansoprazole	0.3	0.3	0.5	0.4	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.3	-0.8
Medication: Omeprazole	0.3	0.4	0.5	-0.5	-0.7
Comparative height size at age 10	0.3	1.4	1.9	-1.0	-1.4
Average weekly red wine intake	0.3	0.4	0.6	0.8	0.5
Diabetes diagnosed by doctor	0.3	0.4	0.8	-0.3	-0.9
Eye problems/disorders: Cataract	0.3	0.3	0.6	0.2	0.8
Ever taken oral contraceptive pill	0.3	0.3	0.7	0.1	0.8
Hearing aid user	0.3	0.3	0.3	-0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.6	-0.8	-0.4
Neuroticism (Nagel 2018)	0.2	0.6	0.9	1.0	0.5
Ulcerative Colitis (UC)	0.2	0.4	0.8	0.0	0.9
HbA1C	0.2	0.2	0.2	-0.5	-0.5
BMI	0.2	1.1	1.2	1.1	1.0
Cardiovascular Disease	0.2	0.5	0.9	0.9	0.5
Respiratory disease	0.2	0.4	0.5	-0.5	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.4	0.5	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	-0.6	-0.1
Supplements: Zinc	0.2	0.2	0.4	-0.2	-0.6
Waist circumference	0.2	0.9	1.6	-0.4	-1.2
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.1	0.8
Happiness	0.2	0.2	0.3	-0.4	-0.6
Depression (self-reported)	0.2	0.2	0.3	0.2	0.6
Loud music exposure frequency	0.2	0.2	0.3	-0.6	-0.3
Neck or shoulder pain in last month	0.2	0.2	0.3	0.4	0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.7	-0.0
Financial situation satisfaction	0.2	0.3	0.6	0.8	-0.0
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.1	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.4	0.6	0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.3	0.7
Worry (Nagel 2018)	0.1	0.2	0.3	-0.4	-0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.7	-0.2
Ovarian Cancer	0.1	0.1	0.2	-0.0	-0.4
Blood Platelet Count	0.1	0.8	1.3	0.6	1.1
Waist Hip Ratio (WHR)	0.1	0.3	0.4	0.5	0.6
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.8	-0.2
Chronotype (morning person)	0.1	0.1	0.3	-0.5	-0.1
Hand grip strength (left)	0.1	0.3	0.5	-0.7	-0.4
Medication: Co-codamol	0.1	0.1	0.1	-0.0	-0.4
Trunk fat percentage	0.1	0.5	0.9	-0.3	-1.0
Maternal smoking around birth	0.1	0.1	0.2	-0.4	-0.1
Taking other prescription medications	0.1	0.1	0.2	-0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.2	-0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	0.5	0.3
Qualifications: None of the above	0.1	0.3	0.5	-0.2	-0.7
Heart attack	0.1	0.1	0.1	-0.3	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.5	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.0	0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.3	-0.4
Qualifications: College or University degree	0.1	0.3	0.7	-0.0	0.8
Migraine (self-reported)	0.1	0.1	0.1	0.3	0.3
Mean time to correctly identify matches	0.1	0.2	0.3	0.5	0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.1	-0.3
Smoking status: Previous	0.1	0.1	0.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.3	0.5
Loneliness, isolation	0.1	0.1	0.2	-0.2	0.4
Ever had bowel cancer screening	0.1	0.1	0.2	0.1	0.5
Friendships satisfaction	0.1	0.1	0.1	0.2	-0.4
Qualifications: nursing, teaching	0.1	0.1	0.1	-0.3	0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.1	-0.3	-0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.3	-0.2	-0.5
Alcohol drinker status: Never	0.1	0.1	0.1	0.4	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.5	-0.0
Age started oral contraceptive pill	0.1	0.1	0.2	-0.0	0.5
Cholesterol lowering medication	0.1	0.1	0.3	0.5	0.1
Pain experienced in last month	0.1	0.1	0.1	0.3	0.4
Supplements: Calcium	0.1	0.1	0.2	-0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	-0.4	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.0	0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.3	0.1
Fasting Glucose	0.0	0.0	0.1	-0.3	-0.1
HDL Cholesterol	0.0	0.0	0.0	-0.0	-0.0
Blood Eosinophil Count	0.0	0.0	0.0	0.0	-0.2
Blood Red Count	0.0	0.4	0.8	-0.9	-0.0
Heel T-Score	0.0	0.1	0.1	-0.3	0.3
Smoking Status	0.0	0.1	0.1	0.4	0.0
Allergy or Eczema	0.0	0.0	0.0	-0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.4	0.2
Neuroticism	0.0	0.1	0.2	0.4	-0.1
Hair Pigment	0.0	1.1	1.2	1.0	1.1
Tanning	0.0	0.1	0.1	-0.2	0.3
Relative age of first facial hair	0.0	0.0	0.0	0.0	-0.0
Hand grip strength (right)	0.0	0.1	0.1	-0.3	-0.1
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.1	-0.0
Relative age voice broke	0.0	0.0	0.1	-0.1	0.2
Supplements: Glucosamine	0.0	0.0	0.0	0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.2	-0.2
Financial difficulties in last 2 years	0.0	0.0	0.1	0.2	-0.0
Noisy workplace	0.0	0.0	0.0	-0.1	0.0
Breastfed as a baby	0.0	0.0	0.1	0.2	0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.2	-0.0
Gout (self-reported)	0.0	0.0	0.0	0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.2	0.1
Alcohol intake frequency.	0.0	0.1	0.1	0.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	0.0	0.2
Back pain experienced in last month	0.0	0.0	0.1	0.0	-0.3
Medication: Atorvastatin	0.0	0.0	0.0	0.1	0.0
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

FAM66D

Models

Trait associations