TWAS hub - IL4I1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0258	0.0096	0.00063	0.001	0.006	0.006	0.006	0.004	0.2000	0.00310	0.003	0.0032	0.013
2	TCGA	Breast Invasive Carcinoma	0.0319	0.0154	0.00290	0.001	0.002	0.000	NA	0.002	0.1900	0.10000	0.330	NA	0.110
3	TCGA	Brain Lower Grade Glioma	0.0351	0.0177	0.00560	0.000	0.022	0.013	NA	0.006	0.3700	0.00130	0.012	NA	0.062
4	TCGA	Prostate Adenocarcinoma	0.0574	0.0300	0.00910	0.025	0.017	0.010	NA	0.013	0.0011	0.00590	0.025	NA	0.015
5	TCGA	Testicular Germ Cell Tumors	0.1530	0.0880	0.00300	-0.008	0.054	0.020	NA	-0.001	0.8000	0.00570	0.066	NA	0.360
6	TCGA	Thyroid Carcinoma	0.0660	0.0270	0.00025	0.008	0.029	0.004	NA	0.008	0.0530	0.00076	0.120	NA	0.052

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Alzheimer’s Disease (including proxy)	6.1	8.8	14.7	2.0	3.8	1.9	3.8	2.6	2.9
Medication: Ibuprofen	5.3	6.3	13.3	-3.4	-3.5	0.1	-0.7	-3.6	0.8
Medication: Ibuprofen (e.g. Nurofen)	5.0	6.4	14.7	-3.1	-3.8	-0.2	-0.6	-3.6	0.9
Chronic bronchitis/emphysema (mother)	3.5	4.0	10.4	0.0	-2.0	-1.6	-3.2	-0.5	-2.6
Alzheimer’s Disease (in father)	3.3	3.6	5.1	1.1	2.0	1.8	2.2	1.8	2.3
Myopia	3.3	4.7	10.2	3.2	2.3	-1.2	1.3	3.2	0.2
Alcohol drinker status: Previous	3.2	3.7	8.5	0.1	-2.9	-2.1	-1.9	-2.2	-0.7
Mouth/teeth dental problems: Dentures	3.1	5.3	11.3	0.3	-2.0	-3.4	-2.8	-0.8	-2.7
Alzheimer’s Disease (in mother)	3.0	3.5	6.2	1.7	2.3	1.2	2.5	1.2	1.9
Noisy workplace	3.0	3.8	5.9	-1.6	-2.4	-1.4	-2.3	-2.0	-1.7
Migraine (self-reported)	3.0	3.8	12.1	-1.7	-2.1	1.4	-0.2	-3.5	1.1
Basal cell carcinoma (self-reported)	3.0	3.5	12.8	0.1	-0.3	-3.6	-1.7	1.1	-2.0
Medication: Lansoprazole	2.9	3.3	5.8	0.2	1.6	-1.8	-1.9	2.0	-2.4
Had menopause	2.8	3.5	6.7	0.5	1.2	-2.6	-1.6	2.2	-2.2
Medication: Metformin	2.7	3.8	6.8	2.6	0.1	-1.6	-2.1	1.6	-2.6
Irritability	2.7	4.6	8.0	1.3	-2.1	-2.4	-2.8	-0.3	-2.8
Impedance of arm (left)	2.6	11.9	23.5	2.8	1.4	-2.7	-2.8	4.8	-4.8
Fractured/broken bones in last 5 years	2.6	3.4	8.1	1.4	2.8	0.5	1.9	2.4	0.8
Impedance of whole body	2.6	13.2	28.7	3.0	1.7	-2.4	-2.6	5.4	-5.1
Impedance of arm (right)	2.5	11.4	24.9	2.7	0.8	-2.6	-3.2	4.3	-5.0
Medication: Gliclazide	2.4	2.7	5.6	-0.5	-1.1	-2.1	-2.4	-0.9	-2.1
Rheumatoid Arthritis	2.3	3.2	6.8	1.6	2.6	1.2	1.3	2.3	1.3
Trunk fat-free mass	2.3	13.0	28.4	-2.0	-0.6	4.0	3.4	-4.2	5.3
Trunk predicted mass	2.3	12.9	28.1	-2.0	-0.6	4.0	3.4	-4.2	5.3
Lupus	2.2	3.3	8.9	-0.2	-3.0	-1.5	-1.8	-1.8	-1.4
Mouth/teeth dental problems	2.2	3.4	7.7	-0.2	1.3	2.4	2.3	-0.2	2.8
Relative age voice broke	2.1	3.2	8.8	1.8	0.9	-1.7	-0.7	3.0	-1.8
Pain all over the body in last month	2.1	2.3	4.3	0.7	-1.6	-1.4	-1.9	-0.8	-2.1
Medication: Ramipril	2.1	2.7	5.2	1.5	1.2	-2.3	-0.9	1.7	-1.8
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	6.1	1.4	1.9	-1.3	1.2	2.5	-0.1
Medication for pain relief, constipation, heartburn	2.1	3.5	10.8	1.1	3.3	0.4	1.2	2.7	0.4
Impedance of leg (right)	2.0	9.6	22.0	2.2	1.2	-1.8	-2.4	4.7	-4.6
Relative age of first facial hair	1.9	3.8	9.5	3.0	1.5	-0.3	1.2	3.1	-0.7
Health satisfaction	1.9	2.5	4.1	-0.3	-2.0	-1.9	-1.7	-1.2	-1.6
Medication: Seretide 50 evohaler	1.9	2.2	4.1	1.1	1.5	1.2	1.7	2.0	1.3
Whole body water mass	1.9	10.6	24.6	-1.5	-0.2	3.6	3.1	-3.7	5.0
Arm predicted mass (left)	1.9	9.5	21.1	-1.9	-0.4	3.2	2.8	-3.7	4.6
Age at First Birth	1.8	2.5	7.4	1.7	2.0	-0.3	0.1	2.7	-1.0
Stomach or abdominal pain in last month	1.8	2.3	4.9	0.7	1.4	1.3	2.2	0.5	2.1
Medication: Atenolol	1.8	2.2	4.9	-2.0	-1.6	-0.4	0.6	-2.2	1.3
Time employed in main current job	1.8	2.1	4.0	2.0	1.2	0.0	1.8	1.9	0.5
Arm fat-free mass (right)	1.8	9.0	21.5	-1.4	0.2	3.2	3.2	-3.2	4.6
Arm predicted mass (right)	1.8	9.4	22.8	-1.2	0.3	3.4	3.4	-3.0	4.8
Overall health rating	1.8	4.0	8.1	-0.5	-1.5	-2.4	-2.9	-0.9	-2.5
Whole body fat-free mass	1.8	10.6	24.9	-1.4	-0.2	3.5	3.2	-3.7	5.0
Breast cancer (self-reported)	1.8	2.1	6.6	-0.6	-1.7	-0.6	-1.6	-2.6	-0.2
Arm fat-free mass (left)	1.8	9.4	22.2	-1.8	0.1	3.3	2.9	-3.3	4.7
Diabetes diagnosed by doctor	1.7	2.8	5.3	2.1	-0.2	-1.6	-2.1	0.6	-2.3
Diabetes (father)	1.6	2.0	5.3	0.9	-0.2	-1.2	-2.0	0.7	-2.3
Fed-up feelings	1.6	2.9	5.9	-0.5	-2.1	-2.4	-1.7	-0.4	-1.9
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	6.6	-0.6	-0.2	0.1	-2.6	-0.3	-1.8
Diabetes (self-reported)	1.6	2.4	4.4	2.1	0.7	-1.3	-1.5	1.5	-1.9
Depression (self-reported)	1.6	1.9	4.7	-0.9	-0.6	-0.9	-2.1	-0.5	-2.2
Birth weight of first child	1.6	3.0	6.8	-1.9	-0.9	-0.8	-2.6	-0.9	-2.2
Medication: Paracetamol	1.6	2.5	4.6	-2.1	-2.0	-1.1	-1.7	-1.5	-0.7
Neuroticism	1.5	3.6	8.2	0.8	0.1	-2.4	-2.2	1.5	-2.9
Average weekly spirits intake	1.5	1.8	4.4	-1.5	-0.5	-1.1	-2.1	-0.0	-1.7
Angina	1.5	1.9	5.5	-1.8	-1.5	-0.0	-0.8	-2.3	-0.3
Impedance of leg (left)	1.5	7.1	18.8	1.6	1.4	-1.3	-1.7	4.3	-3.8
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	5.9	1.5	-0.6	-0.5	-1.9	1.3	-2.4
Allergy	1.5	3.5	8.4	-1.3	0.8	1.5	2.5	-1.4	2.9
Body Mass Index (BMI) (2010)	1.4	1.9	5.8	-0.5	-2.4	-0.8	-1.0	-1.9	-0.4
Current tobacco smoking	1.4	2.2	5.9	-0.2	-2.0	0.9	0.9	-2.4	1.3
Medication: Levothyroxine sodium	1.4	2.4	4.7	0.1	-1.7	-1.9	-2.2	-0.9	-1.6
Had other major operations	1.4	1.8	6.8	-1.1	0.3	2.6	0.4	-0.8	1.3
Happiness	1.4	1.7	4.3	-2.1	-1.3	-0.6	-0.4	-1.8	0.1
Qualifications: A levels/AS levels or equivalent	1.4	3.2	6.8	-1.3	1.2	2.6	1.6	-1.1	2.4
Medication: Cholesterol lowering	1.4	2.3	6.6	2.6	1.3	-1.0	-0.1	1.9	-0.9
Prospective memory result	1.4	1.7	4.1	-2.0	-0.4	0.8	0.8	-1.3	1.6
Angina (self-reported)	1.4	1.8	5.3	-1.7	-1.5	0.0	-0.6	-2.3	-0.1
Leg pain on walking	1.4	1.8	4.7	-1.7	-1.4	0.8	-0.8	-2.2	0.2
Leg fat-free mass (right)	1.4	7.2	18.7	-1.1	0.3	2.7	2.7	-3.0	4.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	4.6	-0.5	-0.7	-2.1	-1.4	-0.5	-1.5
Leg predicted mass (right)	1.4	7.3	18.9	-1.0	0.2	2.7	2.7	-3.0	4.3
Basal metabolic rate	1.4	7.9	19.2	-1.3	-0.0	3.0	2.6	-3.3	4.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.1	-0.8	-2.0	-0.4	-0.4	-2.0	0.8
Mean Putamen Volume	1.3	1.5	2.6	-0.5	-1.6	-1.6	-1.3	-0.7	-1.1
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.7	1.3	0.1	-1.6	-1.1	0.9	-1.6
Hypothyroidism (self reported)	1.3	3.1	6.2	0.3	-2.0	-1.8	-2.5	-0.7	-2.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.2	1.8	-0.6	-1.4	-2.0	-0.2	-2.3
Serious illness, injury or assault to yourself	1.3	1.6	3.1	-0.7	-1.8	-0.5	-1.4	-1.7	-0.7
Sitting height	1.3	9.4	17.8	-1.6	-0.2	4.2	3.0	-3.0	4.2
Exposure to tobacco smoke at home	1.3	1.5	3.3	0.7	-0.9	-1.0	-1.8	0.1	-1.8
Shortness of breath walking on level ground	1.3	1.5	4.2	-2.0	-1.4	-0.2	-1.1	-1.2	-0.5
Smoking status: Current	1.3	2.1	5.1	-0.3	-1.8	1.1	1.0	-2.3	1.3
Medication: Co-codamol	1.2	1.4	4.7	-1.2	-0.6	-2.2	-1.0	-0.2	-1.0
Chronic bronchitis/emphysema (father)	1.2	1.4	3.2	-0.5	-0.5	-1.5	-1.8	-0.3	-1.5
Nervous feelings	1.2	2.3	4.8	0.0	-1.7	-1.6	-1.9	-0.1	-2.2
Neuroticism score	1.2	2.6	5.5	0.5	-1.2	-1.9	-2.1	0.1	-2.3
Headache pain in last month	1.2	2.1	5.6	-1.0	-2.4	1.0	-0.2	-2.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.7	-1.1	-1.9	-0.3	-1.5	-0.9	-1.2
Eye problems/disorders: None of the above	1.2	1.4	4.7	2.2	0.6	0.6	1.0	1.3	0.6
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.6	-0.4	0.2	-0.7	-1.6	0.8	-2.1
Alcohol intake frequency.	1.2	2.9	8.6	-1.2	-2.4	-0.1	-0.5	-2.9	1.0
Average weekly champagne plus white wine intake	1.2	1.7	4.7	1.8	1.1	0.1	0.4	2.2	-0.8
Commuting to job workplace: Cycle	1.2	1.5	2.9	0.8	-0.0	-1.6	-1.0	1.2	-1.7
Primary Biliary Cirrhosis	1.1	1.6	4.2	-0.6	-1.1	0.2	-2.0	-1.4	-1.3
Chronotype (morning person)	1.1	2.6	6.5	-0.6	-0.7	-1.7	-2.5	-0.7	-2.2
Hearing difficulty/problems: Yes	1.1	1.6	6.2	-2.5	0.2	0.8	0.4	-1.2	1.1
Pack years adult smoking proportion	1.1	1.6	4.6	0.2	-2.1	0.7	-0.5	-1.9	-0.7
Hand grip strength (right)	1.1	3.0	5.6	-1.6	-0.6	2.4	1.4	-1.8	2.1
Peak expiratory flow (PEF)	1.1	2.5	6.8	0.0	0.5	2.0	1.9	-0.7	2.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.1	1.8	0.1	-1.1	-0.5	1.4	-1.4
Ever had bowel cancer screening	1.1	1.3	3.6	0.7	1.9	-1.1	-0.3	1.5	-0.7
Qualifications: nursing, teaching	1.1	1.7	3.6	-0.2	1.5	1.2	1.7	-0.3	1.9
Number of self-reported non-cancer illnesses	1.1	1.9	4.3	-0.4	-2.1	-0.7	-1.6	-1.7	-1.0
Pack years of smoking	1.1	1.6	4.5	-0.3	-2.1	0.3	-0.7	-2.0	-0.9
Lung FEV1/FVC ratio	1.0	5.0	10.5	-1.0	-3.2	-2.7	-2.0	-2.6	-1.0
Leg fat-free mass (left)	1.0	5.3	13.9	-0.5	0.3	2.3	2.3	-2.6	3.7
Taking other prescription medications	1.0	1.6	4.7	-1.1	-1.3	0.1	-2.2	-0.6	-1.2
Leg predicted mass (left)	1.0	5.2	14.1	-0.4	0.4	2.3	2.3	-2.5	3.8
Number of incorrect matches in round	1.0	1.6	5.6	0.8	2.4	-0.4	0.5	1.7	0.2
Medication: Simvastatin	1.0	1.5	2.8	1.6	0.6	-1.7	-1.1	0.6	-1.2
Father’s age at death	1.0	1.3	3.1	0.2	-0.3	-1.1	-1.7	0.7	-1.8
Pulse rate	1.0	1.6	4.4	-2.0	-1.0	0.1	-0.1	-2.1	0.6
Hair/balding pattern: Pattern 4	1.0	2.4	5.6	1.7	1.8	-1.4	0.4	2.4	-0.9
Pulse wave reflection index	1.0	1.2	3.1	0.3	-1.8	-0.7	-0.6	-1.7	-0.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.6	-0.6	0.4	1.0	0.8	-1.9	1.9
Medication: Atorvastatin	1.0	1.2	4.2	2.1	0.6	-1.0	1.0	0.8	0.2
Bipolar Disorder (2018)	0.9	1.4	2.7	-0.9	-1.4	1.0	-1.6	-1.3	-0.5
Worry (Nagel 2018)	0.9	1.9	4.3	1.0	0.1	-1.4	-1.2	1.7	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	6.9	-1.5	-1.6	-0.0	-0.7	-2.6	-0.1
Alcohol usually taken with meals	0.9	1.5	3.7	0.7	1.9	-0.5	-0.9	1.8	-0.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.2	-1.0	-0.9	0.7	-1.8	-0.4	-1.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.8	-1.6	-1.2	-0.2	-0.8	-1.7	-0.3
Lung cancer (father)	0.9	1.0	4.8	2.2	0.1	0.8	0.1	0.7	-0.4
Tense / ‘highly strung’	0.9	1.6	4.1	0.3	-1.2	-0.1	-1.9	0.2	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.5	-1.1	-1.0	-1.6	-1.3	-0.5	-1.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	5.9	-2.4	-0.9	-0.0	-0.1	-1.6	0.4
Pulse wave peak to peak time	0.9	1.1	2.8	0.6	1.6	0.6	0.5	1.7	-0.3
Suffer from ‘nerves’	0.9	1.4	2.6	1.6	-0.1	-1.2	-0.4	1.6	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	3.3	0.3	-0.1	-1.8	-1.3	0.6	-1.0
Commuting to job workplace: Walk	0.9	1.0	1.7	0.6	-0.4	-1.3	-1.2	0.8	-1.2
Wears glasses or contact lenses	0.9	1.1	3.2	-0.0	0.6	-1.8	-0.7	1.3	-0.8
Unable to work because of sickness or disability	0.9	1.2	2.9	1.1	-0.3	-1.1	-1.3	0.4	-1.7
Neuroticism (Nagel 2018)	0.8	1.9	3.5	0.9	-0.5	-1.7	-1.3	1.4	-1.9
Blood Red Count	0.8	8.0	21.6	4.7	2.2	0.8	2.1	4.0	-0.0
Allergy or Eczema	0.8	2.0	5.9	1.1	0.2	-0.7	-1.1	2.4	-1.8
Respiratory disease	0.8	1.8	3.7	1.1	-0.7	-1.5	-1.6	0.7	-1.9
Number of treatments/medications taken	0.8	1.4	2.5	-1.3	-1.4	-0.7	-1.6	-0.9	-1.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.0	0.7	-0.2	-1.2	-0.9	0.5	-1.4
Vitamin and mineral supplements	0.8	1.1	3.6	-1.9	-0.2	0.6	0.2	-1.5	0.4
Supplements: Zinc	0.8	0.9	1.8	-0.7	-0.8	-1.1	-1.3	-0.1	-1.0
Trunk fat percentage	0.8	3.0	5.4	0.9	0.9	-2.1	-2.2	1.5	-2.3
Forced vital capacity (FVC)	0.8	3.0	6.7	-0.7	0.5	2.6	1.7	-1.1	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.5	-1.6	-1.2	0.2	-0.4	-2.5	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.4	-1.2	-1.5	-0.0	-1.2	-1.5	-0.3
Pulse wave Arterial Stiffness index	0.8	1.0	2.7	-0.6	-1.5	-0.5	-0.3	-1.6	0.5
Medication: Paracetamol	0.8	1.3	2.5	-1.5	-1.6	-0.6	-1.1	-1.2	-0.3
Gout (self-reported)	0.8	1.1	2.2	-1.5	-1.0	0.3	-1.4	-1.1	-0.6
Medication: Amlodipine	0.8	1.1	2.6	0.5	-1.6	-1.0	-1.0	-1.0	-1.1
Leg fat percentage (right)	0.8	2.8	5.3	0.4	0.4	-2.3	-2.1	1.4	-2.2
Number of full brothers	0.8	0.9	2.7	-0.9	-0.6	1.3	0.1	-1.6	0.4
Worry too long after embarrassment	0.8	1.3	3.2	-0.2	-0.7	-0.6	-1.8	0.8	-1.8
Qualifications: College or University degree	0.8	2.6	5.1	-0.4	2.2	1.9	1.3	1.9	1.1
Mean time to correctly identify matches	0.8	1.5	3.4	1.1	0.8	-1.0	-1.0	1.3	-1.8
Age at last live birth	0.8	1.1	3.7	1.9	0.5	0.5	0.4	1.6	0.0
Supplements: Vitamin C	0.8	0.9	1.9	1.4	0.0	-1.0	-0.7	1.0	-1.2
Average weekly red wine intake	0.8	1.2	4.8	0.6	1.1	-0.4	0.2	2.2	-0.7
Back pain experienced in last month	0.8	1.1	2.9	-1.7	-0.6	0.8	0.2	-1.3	1.0
Commuting to job workplace: Public transport	0.8	1.0	3.9	-0.5	2.0	-0.3	0.2	1.3	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.2	-0.3	-1.8	0.8	-0.2	-1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.1	-0.3	1.1	-1.2	-0.2	1.5	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	0.3	-0.1	-0.9	-1.3	0.7	-1.4
Qualifications: CSEs or equivalent	0.7	0.9	2.1	0.9	0.6	-0.1	1.4	-0.4	1.4
Hearing difficulty/problems with background noise	0.7	1.1	3.3	-1.8	-0.1	-0.6	-1.4	-0.0	-1.0
Heart attack	0.7	0.9	2.1	0.7	-0.6	-1.1	-1.0	0.3	-1.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.0	-0.9	0.0	2.1	1.3	-1.4	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.3	-1.8	-0.7	1.6	0.5	-2.1	1.7
Standing height	0.7	6.6	16.2	0.3	1.3	4.0	3.0	-0.7	3.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.0	0.3	-1.4	-1.2	-1.7	-0.6	-1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.5	-1.3	1.6	-0.3	-0.5	0.7	-0.1
Body fat percentage	0.7	2.8	4.9	0.8	0.9	-2.2	-2.0	1.5	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.9	-1.1	-1.3	0.3	0.2	-1.4	0.2
Heart disease (mother)	0.7	0.9	2.8	-1.7	-0.4	-0.7	-1.1	-0.7	-0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.0	-1.1	-0.3	-0.4	-0.3	-1.7	0.6
Eye problems/disorders: Cataract	0.7	0.8	3.3	-1.8	0.5	0.1	0.1	-0.7	0.8
Asthma (self-reported)	0.7	1.4	2.6	0.7	-0.6	-1.6	-1.3	0.7	-1.6
High cholesterol (Self-reported)	0.7	1.3	5.8	2.4	0.2	-0.5	-0.3	0.9	-0.8
Illnesses of father: High blood pressure	0.7	0.9	1.8	0.7	0.1	1.2	0.7	-1.1	1.3
Pain experienced in last month	0.7	1.2	2.6	1.5	1.1	-0.7	0.6	1.6	0.2
LDL Cholesterol	0.6	0.9	2.2	0.3	-1.0	-0.4	-1.5	-1.4	-0.3
Ulcerative Colitis	0.6	0.9	3.4	-0.0	-0.5	0.2	-1.4	0.4	-1.8
Maternal smoking around birth	0.6	0.9	2.0	-1.4	-1.1	0.9	-0.7	-0.8	-0.3
High blood pressure (mother)	0.6	0.9	1.7	-0.6	-1.0	1.3	-1.3	-0.7	-0.4
Qualifications: None of the above	0.6	1.3	3.1	0.4	-1.3	-0.4	-1.6	-0.2	-1.8
Asthma	0.6	1.1	2.1	1.0	-0.4	-1.4	-1.0	0.9	-1.3
Length of working week for main job	0.6	0.7	2.1	1.5	0.6	0.3	0.2	0.9	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.1	4.2	-1.4	-0.1	2.1	0.7	-1.7	1.8
Pulse rate, automated reading	0.6	1.9	5.5	-2.4	-0.4	-1.4	-1.4	-1.3	-0.6
Comparative height size at age 10	0.6	3.4	9.2	-0.4	0.2	1.7	2.6	-1.4	3.0
Number of full sisters	0.6	0.7	1.9	1.4	-0.8	0.7	0.8	0.7	0.3
Medication: Aspirin	0.6	0.8	1.2	1.1	-1.0	-1.0	-0.8	-0.4	-0.9
Knee pain experienced in last month	0.6	0.9	2.9	0.6	-1.7	-0.6	-0.9	-0.8	-0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.5	1.6	0.4	0.7	0.3	1.0	0.1
Loneliness, isolation	0.6	0.9	1.6	1.3	-1.2	-0.7	-0.9	-0.7	-0.5
Long-standing illness, disability or infirmity	0.6	1.0	1.7	-1.2	-0.7	-1.3	-1.2	-0.6	-0.5
Mother’s age at death	0.6	0.8	1.9	0.6	1.3	0.8	0.2	1.4	-0.1
Medication: Bendroflumethiazide	0.6	0.9	2.5	0.4	-0.7	-1.6	-0.9	-0.3	-1.2
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.6	0.9	-0.6	-0.9	-0.9	0.4	-1.3
Ovarian Cancer	0.5	0.7	1.6	-0.3	0.6	1.1	1.3	0.2	0.9
Neuroticism (2016)	0.5	0.7	1.8	1.3	0.6	-0.1	0.7	1.3	0.0
Triglycerides	0.5	0.8	2.0	0.8	-0.9	0.2	-1.4	-1.0	-0.2
Blood White Count	0.5	3.7	6.8	1.6	2.6	0.8	2.1	1.2	2.5
Hand grip strength (left)	0.5	1.2	2.0	-0.8	-0.4	1.4	1.1	-1.1	1.4
Sensitivity / hurt feelings	0.5	0.9	2.6	1.6	0.5	0.0	-0.1	1.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	0.8	-0.4	-1.1	-0.6	0.4	-1.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.4	0.5	0.1	-0.6	-1.3	1.4	-1.6
Supplements: Glucosamine	0.5	0.7	1.8	-0.5	1.3	-1.0	0.2	1.0	-0.0
Breastfed as a baby	0.5	0.6	1.5	-1.2	0.1	-1.0	-0.7	-0.1	-0.5
Loud music exposure frequency	0.5	0.5	1.5	-0.0	-0.4	-0.6	-1.0	0.2	-1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.6	1.3	0.7	1.0	0.3	0.8	-0.3
Medication: Allopurinol	0.5	0.7	3.2	0.1	-0.5	1.8	-0.5	-0.7	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.9	-0.7	-1.2	-0.7	0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	0.8	-0.2	-1.0	-0.3	0.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	0.1	-1.5	1.4	-0.2	-1.3	0.4
Mineral and other dietary supplements	0.5	0.7	2.0	0.5	-1.4	0.5	-0.4	-1.0	-0.9
Osteoarthritis (self-reported)	0.5	0.6	1.0	-0.8	-0.9	-0.7	0.4	-1.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.4	-1.3	-0.9	-0.3	-1.2	-1.5	-0.0
Guilty feelings	0.5	0.7	1.9	0.6	0.3	-0.7	-0.8	1.0	-1.4
Medication: Blood pressure	0.5	0.9	2.5	-0.2	-1.0	-1.6	-0.8	-0.8	-0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	-1.2	0.1	0.2	0.9	-0.8	0.8
Leg fat percentage (left)	0.5	1.8	3.6	-0.0	0.6	-1.9	-1.6	1.2	-1.6
Number of operations (self-reported)	0.5	0.7	3.3	1.8	0.4	0.0	0.2	0.9	-0.0
Risk taking	0.5	0.7	2.5	-0.1	1.6	0.7	0.4	1.0	-0.4
Age started oral contraceptive pill	0.5	0.6	1.4	1.0	1.2	0.4	0.3	1.0	0.1
Ever depressed for a whole week	0.5	0.6	1.1	-0.1	-0.9	-0.9	-1.0	-0.7	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.7	-1.0	1.2	1.1	1.5	0.7	1.7
Supplements: Calcium	0.5	0.6	1.0	1.0	0.7	-0.9	0.4	1.0	0.4
Irritable Bowel Disease (IBD)	0.4	1.0	1.7	-1.1	-1.3	0.4	-1.0	-0.6	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.9	-0.8	1.4	-0.8	-0.4	1.3	-0.5
Fasting Glucose	0.4	0.5	1.6	-0.6	0.2	-0.4	1.2	0.2	1.0
HDL Cholesterol	0.4	0.8	1.7	-0.3	1.3	0.5	1.1	1.1	0.1
Smoking Status	0.4	1.0	2.3	-0.4	-1.3	0.4	0.8	-1.5	1.0
Systolic blood pressure, automated reading	0.4	1.2	2.7	-1.1	-1.0	-0.9	-1.2	-1.7	-0.3
Average weekly fortified wine intake	0.4	0.4	1.1	0.7	-0.1	1.0	0.4	-0.4	0.9
High blood pressure	0.4	1.1	1.8	1.1	-1.0	-0.8	-1.3	-0.8	-1.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	-1.2	-0.4	-0.1	0.5	-0.7	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.4	-1.0	-0.4	-1.0	-0.6	-0.8
Financial difficulties in last 2 years	0.4	0.5	1.3	-0.5	0.1	-0.6	-1.1	-0.4	-1.1
Fluid intelligence score	0.4	0.9	2.9	0.1	1.5	-0.3	0.1	1.7	-0.1
Worrier / anxious feelings	0.4	0.8	2.4	0.3	-0.2	-0.6	-1.3	0.4	-1.5
Falls in the last year	0.4	0.5	1.5	1.2	0.6	-0.0	0.6	1.0	0.2
Number of live births	0.4	0.5	1.6	1.3	1.1	0.2	-0.4	0.1	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.2	-0.2	-1.0	0.4	-0.7	-1.1	0.2
Birth weight	0.4	0.8	1.6	-1.1	0.3	0.8	0.2	-1.1	1.3
Emphysema/chronic bronchitis	0.4	0.5	1.6	1.3	0.3	0.2	0.0	0.9	-0.7
Medication: Blood pressure	0.4	0.7	3.1	1.8	0.7	0.6	0.1	0.6	-0.2
Had major operations	0.4	0.4	0.8	0.7	-0.2	-0.9	-0.7	0.2	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.0	0.8	0.2	0.3	0.7	-0.5	1.0
Hypertension (Self-reported)	0.4	1.0	1.6	0.9	-0.8	-1.0	-1.3	-0.5	-1.2
Arm fat percentage (left)	0.4	1.5	3.9	0.5	0.3	-2.0	-1.5	0.6	-1.4
Mood swings	0.4	0.7	2.4	1.6	0.9	-0.3	0.3	0.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.8	0.5	-0.6	0.6	0.8	0.6
Medication for cholesterol	0.4	0.7	1.8	0.3	1.3	0.6	0.0	1.3	-0.4
Medication: Aspirin	0.4	0.5	1.0	1.0	-0.5	-1.0	-0.5	0.1	-0.8
Financial situation satisfaction	0.4	0.5	1.3	-0.7	1.1	-0.7	-0.5	0.4	-0.4
Alcohol drinker status: Never	0.4	0.5	1.0	-1.0	-0.5	0.9	0.1	-0.7	0.5
Diastolic blood pressure, automated reading	0.4	1.4	2.6	-1.1	-1.0	1.0	0.3	-1.6	1.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	-0.1	-0.9	1.5	-0.5	-1.2	0.4
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	0.2	-0.8	-1.5	-0.5	0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.9	-0.6	1.7	-0.2	0.4	1.1	0.3
Schizophrenia (2018)	0.3	0.5	1.3	0.6	-0.1	1.2	0.7	-0.4	1.0
Ulcerative Colitis (UC)	0.3	0.7	1.1	-1.1	-0.7	0.7	-0.8	-0.9	-0.6
Breast Cancer	0.3	0.7	2.2	-1.5	0.4	-1.2	0.0	0.5	-0.3
HbA1C	0.3	0.4	1.6	-0.3	0.3	-1.2	-0.5	-0.3	-0.4
Schizophrenia (2014)	0.3	0.6	1.6	0.2	-1.2	1.0	0.2	-0.9	0.6
Height	0.3	5.8	13.8	-1.1	-0.8	3.7	1.7	-2.7	3.0
Waist Hip Ratio (WHR)	0.3	1.3	2.3	1.0	1.2	0.5	1.4	1.5	0.7
Lung FVC	0.3	1.4	2.8	-1.6	-1.2	-0.2	-1.3	-1.7	-0.3
Townsend deprivation index at recruitment	0.3	0.4	1.9	1.4	-0.1	0.0	0.3	0.8	0.0
Age when periods started (menarche)	0.3	0.7	2.1	-0.1	-1.4	-0.1	-1.0	-0.3	-1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	-0.4	-0.2	-0.9	-1.0	-0.5	-0.4
Weight	0.3	1.6	4.2	-0.8	0.2	1.0	0.8	-1.7	2.0
Arm fat percentage (right)	0.3	1.2	2.8	0.2	0.1	-1.7	-1.5	0.3	-1.3
Alcohol intake versus 10 years previously	0.3	0.4	1.6	1.2	0.1	-0.1	0.1	0.5	-0.7
High blood pressure (siblings)	0.3	0.5	1.5	1.2	-0.1	1.0	0.0	0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.6	-1.0	0.5	1.3	0.4	0.1	0.3
Osteoporosis (self-reported)	0.3	0.3	1.1	1.1	0.1	0.2	0.0	0.8	-0.4
Ever taken oral contraceptive pill	0.3	0.3	1.2	1.1	0.0	0.6	-0.2	0.7	-0.1
Hearing aid user	0.3	0.3	1.7	-0.4	-0.0	1.3	-0.2	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	0.4	-0.4	0.7	0.6	-0.7	0.9
Average weekly beer plus cider intake	0.3	0.4	1.3	-1.1	-0.5	-0.0	0.0	-0.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.5	0.5	0.0	-0.2	0.9	-0.8
Crohns Disease (2017)	0.2	0.4	0.9	-0.3	-0.8	-0.3	-0.6	0.1	-0.9
Prostate Cancer	0.2	0.3	0.7	0.2	0.9	0.5	0.2	0.7	0.7
Crohns Disease (2012)	0.2	0.3	0.9	0.9	-0.6	0.1	-0.1	0.5	-0.1
Blood Eosinophil Count	0.2	1.4	4.6	2.1	1.4	-0.1	-0.2	1.4	-0.1
Systolic Blood Pressure	0.2	1.1	4.1	-0.6	-1.1	0.8	-0.2	-2.0	0.6
Hair Pigment	0.2	5.9	14.7	0.7	0.4	3.1	3.1	-1.1	3.8
Tanning	0.2	2.5	4.8	2.1	1.4	1.8	0.7	2.2	0.2
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.2	-0.4	-0.3	0.1	-0.7	0.7
Diabetes (mother)	0.2	0.3	0.8	-0.5	0.5	0.9	-0.0	-0.2	0.6
Multivitamins +/- minerals	0.2	0.3	0.9	0.9	-0.3	-0.3	0.4	0.6	0.4
Body mass index (BMI)	0.2	0.9	2.9	-1.0	-0.5	-0.7	-0.5	-1.7	0.7
Past tobacco smoking	0.2	0.5	1.3	1.1	0.2	-0.3	-0.5	0.5	-0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	-0.6	0.5	0.3	-0.5	-0.0	-0.5
Illnesses of siblings	0.2	0.3	0.6	-0.2	0.8	-0.7	0.6	0.6	-0.1
Illnesses of mother	0.2	0.3	1.2	0.3	0.2	-0.3	1.1	0.3	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.6	-0.3	-0.2	-0.4	0.1	-0.8
Glaucoma (self-reported)	0.2	0.2	0.7	0.3	-0.3	-0.0	0.7	-0.3	0.8
Comparative body size at age 10	0.2	0.5	1.6	0.7	-0.6	-1.3	-0.3	-0.7	-0.1
Age at first live birth	0.2	0.3	0.9	0.9	0.3	0.6	0.5	0.4	0.5
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.1	-0.3	0.9	0.5	-0.7	0.7
Medication: Omeprazole	0.2	0.2	0.5	0.4	0.7	0.4	0.5	0.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.5	-0.4	-0.5	-0.7	-0.3	-0.5
Smoking status: Previous	0.2	0.3	0.9	-0.9	0.7	-0.2	0.1	0.5	0.3
Friendships satisfaction	0.2	0.3	0.5	0.7	-0.6	0.1	-0.6	0.1	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.7	0.9	-0.4	-0.4	-0.2	0.4	-0.4
Miserableness	0.2	0.3	0.9	0.2	-0.6	-0.3	0.4	-0.9	0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.5	-0.6	-0.7	0.1	-0.4	0.7
Ever smoked	0.2	0.4	0.8	-0.6	-0.5	0.6	0.2	-0.8	0.9
Cholesterol lowering medication	0.2	0.3	0.7	0.8	-0.1	-0.8	-0.4	-0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	0.3	-0.5	0.8	-0.3	-0.6	0.5
Heart disease (siblings)	0.2	0.2	0.6	0.6	-0.2	0.2	0.7	0.4	0.2
Depression (Nagel 2018)	0.1	0.2	1.0	-0.1	-1.0	0.1	-0.2	-0.4	0.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.8	-0.0	0.9	0.2	0.4	-0.0	-0.1
Major Depression (MDD)	0.1	0.1	0.4	-0.6	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.1	0.2	0.8	0.4	0.0	-0.4	-0.4	0.1	-0.9
Heel T-Score	0.1	0.5	1.5	-0.9	-0.1	-1.2	-0.2	-0.7	-0.6
BMI	0.1	0.8	3.0	-0.5	-0.4	-0.2	-0.0	-1.7	1.2
Cardiovascular Disease	0.1	0.4	1.2	1.1	-0.8	-0.1	0.1	-0.6	0.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.2	-0.7	0.2	-0.4	-0.4	-0.1
Severe depression (siblings)	0.1	0.1	0.5	-0.1	0.4	-0.2	0.3	0.7	-0.1
Trunk fat mass	0.1	0.4	1.0	0.3	0.6	-0.9	-1.0	0.2	-0.6
Waist circumference	0.1	0.3	0.8	0.2	0.8	0.3	0.3	-0.1	0.9
Hip circumference	0.1	0.3	0.8	-0.3	-0.1	0.5	-0.3	-0.9	0.8
Arm fat mass (right)	0.1	0.3	0.9	-0.4	0.1	-0.4	-0.3	-1.0	0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.2	-0.0	0.6	0.3	-0.0	0.2
Chest pain or discomfort	0.1	0.1	0.3	-0.6	0.0	0.1	0.4	-0.3	0.2
Family relationship satisfaction	0.1	0.1	0.6	0.4	0.2	-0.2	-0.0	0.8	-0.0
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.6	0.6	-0.6	-0.2	0.1	-0.2
Arm fat mass (left)	0.1	0.2	0.8	-0.2	0.2	-0.2	-0.1	-0.9	0.8
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	0.0	0.2	-0.0	0.4	0.1	0.8
Medication: Lisinopril	0.1	0.1	0.3	0.6	-0.2	0.3	-0.1	0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	1.3	0.3	-0.6	1.1	-0.2	-0.1	0.9
Number of children fathered	0.0	0.0	0.1	0.1	-0.2	0.1	-0.2	-0.1	-0.4
Whole body fat mass	0.0	0.2	0.5	0.2	0.7	-0.6	-0.5	0.1	-0.1
Leg fat mass (right)	0.0	0.2	0.5	0.1	0.5	-0.7	-0.6	-0.1	-0.1
Leg fat mass (left)	0.0	0.1	0.5	-0.1	0.7	-0.5	-0.2	-0.1	0.3

Hub : Genes

IL4I1

Models

Trait associations