TWAS hub - MED25

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0480	0.0200	4.7e-03	0.012	0.018	0.006	0.016	0.008	1.2e-02	2.2e-03	5.1e-02	0.0041	3.5e-02
2	GTEx	Cells Transformed fibroblasts	0.1160	0.0460	4.2e-03	0.112	NA	0.072	NA	0.092	1.0e-08	NA	4.3e-06	NA	2.1e-07
3	GTEx	Colon Sigmoid	0.2810	0.0830	5.9e-05	0.215	NA	0.171	NA	0.008	4.0e-08	NA	1.2e-06	NA	1.7e-01
4	GTEx	Colon Transverse	0.2520	0.0720	2.0e-04	0.095	NA	0.105	NA	0.126	2.9e-05	NA	1.1e-05	NA	1.3e-06
5	GTEx	Skin Sun Exposed Lower leg	0.1180	0.0330	1.4e-05	0.057	NA	0.090	NA	0.100	1.6e-05	NA	7.1e-08	NA	1.2e-08
6	METSIM	Adipose	0.0464	0.0196	3.0e-03	0.034	0.000	0.021	0.003	0.030	5.8e-06	2.7e-01	3.0e-04	0.0930	2.0e-05
7	TCGA	Breast Invasive Carcinoma	0.0149	0.0084	6.4e-04	0.003	0.016	0.012	NA	0.009	5.4e-02	2.9e-04	1.1e-03	NA	4.0e-03
8	TCGA	Colon Adenocarcinoma	0.1310	0.0710	2.3e-03	0.005	0.023	0.025	NA	0.019	1.5e-01	1.7e-02	1.4e-02	NA	2.6e-02
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2500	0.0910	1.3e-04	0.102	0.072	0.054	NA	0.097	2.0e-06	6.1e-05	5.1e-04	NA	3.5e-06
10	TCGA	Thyroid Carcinoma	0.0270	0.0180	8.5e-03	0.014	0.020	0.020	NA	0.021	1.4e-02	4.1e-03	4.0e-03	NA	3.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Medication: Co-codamol	8.6	9.9	17.8	0.8	4.2	2.0	3.0	3.3	3.8	2.3	3.6	3.8	3.1
Medication: Lansoprazole	5.9	6.7	9.3	2.4	2.2	2.9	2.8	2.7	2.1	3.0	2.6	2.2	2.8
Current tobacco smoking	4.9	7.9	14.4	-3.8	-2.2	-2.9	-2.6	-2.7	-2.4	-3.0	-2.4	-2.5	-3.4
Medication: Ramipril	4.7	6.0	11.4	1.7	2.4	1.9	2.8	3.4	3.0	2.5	2.5	1.6	2.3
Medication: Metformin	4.6	6.5	9.5	1.4	2.6	2.8	2.6	2.5	2.6	3.1	3.0	2.0	2.5
Mean time to correctly identify matches	4.6	8.9	12.4	2.3	3.5	2.5	2.6	2.8	3.2	2.9	3.3	3.3	3.1
Basal cell carcinoma (self-reported)	4.6	5.5	9.2	1.7	2.6	1.6	2.2	3.0	3.0	2.3	2.1	2.2	2.2
Mouth/teeth dental problems: Loose teeth	4.5	5.3	7.7	1.0	2.4	2.5	2.1	2.2	2.0	2.5	2.3	2.6	2.8
Smoking status: Current	4.3	6.8	12.1	-3.5	-2.0	-2.6	-2.4	-2.5	-2.2	-2.8	-2.1	-2.3	-3.2
Had menopause	4.2	5.2	8.6	1.9	2.3	2.4	2.0	2.4	1.7	2.9	2.6	1.9	2.4
Financial situation satisfaction	4.1	5.1	7.6	1.6	2.6	2.3	2.2	1.7	1.7	2.1	2.8	2.6	2.5
Migraine (self-reported)	4.0	5.0	10.4	-2.7	-1.7	-2.4	-2.2	-2.0	-1.9	-3.2	-2.2	-1.1	-2.2
Diabetes (self-reported)	3.6	5.6	8.0	1.1	2.5	2.2	2.6	2.1	2.3	2.8	2.8	2.1	2.6
Medication: Allopurinol	3.4	4.5	7.3	-1.0	-2.5	-1.4	-2.7	-2.1	-2.4	-1.9	-2.7	-1.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	3.1	6.4	8.4	-2.2	-2.7	-2.8	-2.6	-2.3	-2.1	-2.2	-2.9	-2.7	-2.6
Hand grip strength (right)	3.0	8.3	10.8	-2.6	-2.9	-2.7	-3.3	-2.9	-3.3	-2.9	-3.1	-2.1	-2.9
Neuroticism	2.9	7.0	13.2	2.0	2.1	3.6	2.9	2.2	1.9	3.4	3.0	1.4	3.0
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	6.4	0.5	1.8	2.1	2.2	1.1	1.4	2.2	2.5	1.3	1.9
Diabetes diagnosed by doctor	2.9	4.7	6.6	0.3	2.4	1.8	2.4	2.1	2.3	2.4	2.6	2.1	2.3
Medication: Ibuprofen	2.8	3.3	6.7	-2.1	-1.2	-2.6	-2.0	-1.8	-1.2	-2.3	-1.5	-0.9	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	6.2	-1.4	-1.3	-2.5	-2.1	-2.1	-1.4	-2.3	-1.4	-1.1	-2.2
Ever used hormone-replacement therapy (HRT)	2.5	3.1	5.0	0.7	2.2	1.2	1.7	1.8	1.5	1.8	2.2	2.0	2.0
Trunk predicted mass	2.5	14.1	33.1	-5.8	-1.9	-5.6	-3.1	-2.3	-1.7	-5.4	-3.5	-0.9	-3.6
Financial difficulties in last 2 years	2.4	3.2	5.0	1.4	2.1	1.5	1.5	1.2	1.8	1.7	2.2	2.0	2.1
Trunk fat-free mass	2.4	14.0	32.8	-5.7	-1.9	-5.6	-3.1	-2.3	-1.7	-5.4	-3.5	-0.9	-3.6
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	6.8	-1.8	-1.2	-2.6	-2.1	-1.5	-0.9	-1.6	-1.9	-1.0	-1.9
Pulse wave reflection index	2.3	2.9	6.4	-2.5	-1.2	-2.4	-1.3	-1.2	-1.2	-1.5	-1.4	-1.5	-2.0
Overall health rating	2.3	4.8	6.3	1.2	2.5	2.3	2.2	2.3	2.2	1.9	2.4	2.5	2.3
Illnesses of father: High blood pressure	2.3	2.9	4.9	-1.9	-1.5	-2.2	-1.5	-1.5	-1.1	-2.2	-2.0	-1.0	-1.6
Forced vital capacity (FVC)	2.2	8.5	15.0	-2.6	-3.3	-3.0	-2.5	-2.5	-2.5	-3.5	-3.9	-2.3	-2.7
Headache pain in last month	2.2	3.8	8.1	-1.8	-1.4	-2.9	-2.3	-1.9	-1.3	-2.0	-2.0	-1.4	-2.0
Chronotype (morning person)	2.1	4.9	9.6	-0.4	2.7	1.7	1.9	2.0	2.1	1.8	2.3	3.1	2.8
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.9	1.2	1.1	2.0	1.6	1.5	1.2	1.1	0.9	1.6	2.2
Medication: Simvastatin	2.1	3.0	5.2	0.9	1.9	1.5	1.9	1.9	2.3	1.6	1.9	1.5	1.8
Mouth/teeth dental problems: Dentures	2.1	3.5	7.8	1.4	1.8	2.8	1.6	1.5	1.5	2.1	2.6	1.1	1.7
Body fat percentage	2.1	8.4	10.4	2.7	2.9	2.9	3.0	3.1	2.7	3.0	3.0	2.5	3.2
Verbal and Numeric Reasoning (VNR)	2.0	4.7	7.5	1.5	2.4	2.3	2.0	1.6	2.1	2.7	2.7	1.8	2.2
Hand grip strength (left)	2.0	5.2	6.8	-2.5	-2.2	-2.1	-2.5	-2.2	-2.6	-2.1	-2.5	-1.7	-2.2
Diabetes (father)	2.0	2.5	4.6	1.4	1.1	1.2	2.1	2.1	1.5	1.7	1.3	1.2	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	3.2	1.8	1.7	1.5	1.4	1.4	1.4	1.4	1.8	1.7	1.3
Reaction Time	1.9	3.7	6.5	1.4	2.5	1.1	1.5	1.5	2.4	1.6	2.3	2.3	2.0
Age at First Birth	1.9	2.7	6.2	2.5	0.9	2.2	1.5	0.8	0.5	2.5	2.1	0.1	1.2
Trunk fat percentage	1.9	7.8	10.4	2.6	2.7	2.9	2.8	3.0	2.4	3.0	2.7	2.4	3.2
Impedance of arm (left)	1.9	8.6	24.3	4.9	0.6	4.5	2.2	1.9	1.0	4.5	1.7	0.3	3.0
Length of working week for main job	1.9	2.1	3.3	-0.1	1.7	1.8	1.1	1.0	1.1	1.8	1.6	1.8	1.6
Forced vital capacity (FVC), Best measure	1.9	7.0	14.3	-2.7	-3.0	-2.5	-2.3	-2.1	-2.3	-3.2	-3.8	-1.8	-2.2
Leg fat percentage (right)	1.9	6.7	8.0	2.6	2.6	2.6	2.7	2.7	2.3	2.8	2.7	2.1	2.8
Wears glasses or contact lenses	1.9	2.2	4.0	0.7	1.8	1.2	1.7	1.7	1.3	1.7	2.0	1.1	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.6	0.7	1.5	1.6	2.1	1.6	1.6	1.6	2.0	1.0	1.4
Relative age voice broke	1.8	2.7	7.4	2.7	0.6	2.2	1.5	1.1	0.5	2.4	1.6	-0.0	1.5
Number of incorrect matches in round	1.8	3.0	4.8	0.0	1.9	1.4	2.0	2.0	1.4	1.8	1.8	2.2	2.0
Medication: Ventolin 100micrograms inhaler	1.8	2.4	3.7	-0.8	1.7	0.5	1.9	1.6	1.6	1.3	1.6	1.8	1.9
Qualifications: nursing, teaching	1.8	2.9	6.8	-1.1	2.2	0.5	1.4	1.8	2.2	-0.2	0.9	2.6	2.1
Leg fat percentage (left)	1.8	6.6	7.7	2.4	2.7	2.5	2.7	2.7	2.4	2.5	2.8	2.2	2.7
Unable to work because of sickness or disability	1.8	2.4	4.0	0.6	1.5	0.9	2.0	2.0	1.6	1.4	1.4	1.5	1.8
Mouth/teeth dental problems	1.7	2.6	6.9	-1.8	-1.0	-2.6	-0.9	-0.3	-0.3	-2.5	-2.0	-0.9	-1.6
Whole body fat-free mass	1.7	9.7	25.7	-5.1	-1.2	-4.9	-2.3	-1.6	-1.1	-4.7	-2.8	-0.3	-2.8
Ever had bowel cancer screening	1.7	2.0	4.5	0.6	1.2	1.5	1.6	2.1	1.4	1.4	0.9	1.4	1.6
Whole body water mass	1.7	9.7	26.0	-5.1	-1.2	-4.9	-2.3	-1.5	-1.0	-4.7	-2.8	-0.3	-2.7
Commuting to job workplace: Public transport	1.7	2.0	4.0	0.5	1.3	1.9	1.3	1.2	0.9	1.3	1.4	1.6	2.0
Impedance of whole body	1.7	8.9	26.3	5.1	0.3	4.7	2.0	1.3	0.7	4.7	1.8	-0.2	2.9
Arm predicted mass (left)	1.7	8.4	25.5	-5.0	-0.9	-4.5	-2.1	-1.4	-0.9	-4.3	-2.4	-0.1	-2.4
Lupus	1.6	2.4	5.3	-2.3	-1.8	-0.5	-1.7	-1.9	-1.8	-0.7	-1.1	-1.6	-1.2
Supplements: Zinc	1.6	1.7	3.0	0.3	1.6	1.5	0.9	0.8	0.8	1.7	1.7	1.2	1.6
Maternal smoking around birth	1.6	2.4	4.4	0.1	-2.1	-0.1	-1.7	-1.5	-2.0	-1.4	-2.0	-1.6	-1.3
Sitting height	1.6	11.6	27.5	-5.2	-2.3	-4.3	-3.0	-2.4	-2.1	-4.6	-3.7	-1.3	-3.1
Fluid intelligence score	1.6	3.3	5.7	1.6	1.8	1.8	1.8	1.3	1.8	2.4	2.1	1.3	1.8
Depression (self-reported)	1.6	1.9	6.4	1.5	0.9	2.5	1.0	0.5	0.3	1.4	1.7	0.9	1.6
Arm fat percentage (left)	1.6	6.4	9.4	1.9	2.8	2.0	2.6	3.1	2.6	2.2	2.5	2.5	2.8
Ever had prostate specific antigen (PSA) test	1.6	1.8	5.4	-2.3	-0.5	-2.0	-1.2	-0.5	-0.4	-1.9	-1.3	-0.2	-1.3
Impedance of arm (right)	1.5	7.1	20.0	4.5	0.3	4.3	1.9	1.4	0.6	4.2	1.5	-0.1	2.6
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	9.6	-1.2	-2.5	-2.5	-2.1	-2.1	-1.9	-3.0	-3.1	-1.5	-2.1
Arm predicted mass (right)	1.5	7.5	20.2	-4.5	-0.9	-4.5	-2.0	-1.4	-0.8	-4.1	-2.3	-0.1	-2.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.6	-1.1	-1.4	-1.3	-1.4	-1.2	-1.6	-1.3	-1.4	-1.2	-1.4
Alcohol drinker status: Previous	1.5	1.7	4.1	-2.0	-1.3	-1.6	-0.8	-1.1	-0.8	-1.3	-1.0	-1.5	-1.4
Alcohol usually taken with meals	1.4	2.3	3.8	1.2	1.2	1.8	1.5	1.9	1.8	1.4	0.9	1.3	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	8.9	-1.6	-2.1	-2.2	-2.2	-1.8	-1.6	-2.8	-3.0	-1.1	-1.7
Arm fat-free mass (left)	1.4	7.2	20.5	-4.5	-0.8	-4.4	-1.8	-1.2	-0.7	-4.1	-2.2	0.0	-2.3
Age started oral contraceptive pill	1.4	1.7	4.4	-0.0	1.7	-0.1	1.1	1.5	2.1	0.8	1.0	1.6	1.4
Smoking Status	1.3	3.1	10.5	-3.2	-1.3	-1.6	-1.3	-1.0	-1.3	-1.9	-1.3	-1.6	-1.9
Arm fat percentage (right)	1.3	5.0	7.1	1.7	2.6	1.8	2.3	2.7	2.3	1.9	2.2	2.3	2.5
Arm fat-free mass (right)	1.3	6.8	19.1	-4.4	-0.7	-4.3	-1.9	-1.1	-0.6	-4.0	-2.1	0.1	-2.2
Number of full brothers	1.3	1.6	2.6	-1.5	-0.9	-1.4	-1.6	-1.0	-1.4	-1.5	-1.2	-0.2	-1.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.0	-0.6	-1.3	-0.7	-1.4	-1.9	-2.0	-0.4	-0.4	-1.8	-1.4
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.4	0.1	1.6	1.7	1.6	1.1	1.5	1.6	1.8	1.4	1.7
Ever had hysterectomy (womb removed)	1.2	1.4	3.4	-0.2	1.2	0.9	1.0	1.8	1.3	0.9	0.6	1.4	1.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	3.3	-0.7	1.6	0.8	0.6	1.1	1.0	0.9	1.2	1.8	1.3
Supplements: Glucosamine	1.2	1.6	3.7	0.8	1.0	1.2	1.9	1.3	0.9	1.3	1.9	0.3	1.0
Worry too long after embarrassment	1.2	2.0	4.6	0.8	1.1	2.1	1.1	1.1	1.1	2.1	1.4	0.8	1.7
Age at first live birth	1.2	2.1	7.0	-0.2	-1.9	-0.6	-0.9	-1.6	-1.2	-1.1	-1.2	-2.6	-1.6
Neuroticism (Nagel 2018)	1.1	2.6	5.0	1.1	1.1	1.9	2.1	1.4	1.4	2.2	2.1	0.3	1.4
Impedance of leg (right)	1.1	5.2	18.6	4.3	-0.6	3.6	1.0	0.2	-0.2	3.8	0.9	-1.1	1.6
Peak expiratory flow (PEF)	1.1	2.6	5.6	-0.3	-1.5	-2.4	-1.5	-1.4	-1.2	-2.3	-2.0	-0.8	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.9	-1.7	-0.8	-0.8	-1.1	-1.7	-1.1	-1.0	-0.6	-0.7	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.8	0.3	1.7	0.1	1.3	1.1	1.5	-0.1	1.4	1.3	0.6
Breast cancer (self-reported)	1.1	1.3	3.0	-1.7	1.6	-0.0	0.4	1.2	1.7	-0.5	0.6	1.4	0.6
Basal metabolic rate	1.1	6.0	18.1	-4.2	-0.5	-4.0	-1.5	-0.8	-0.4	-3.8	-2.0	0.3	-1.9
Commuting to job workplace: Cycle	1.1	1.4	3.8	0.3	1.0	1.4	0.9	1.2	1.1	1.9	1.0	0.8	1.3
Pain experienced in last month	1.1	1.8	5.1	1.2	-1.9	0.0	-0.7	-0.9	-1.6	-0.3	-1.3	-2.2	-1.4
Worry (Nagel 2018)	1.0	2.1	4.8	1.7	0.6	2.2	1.5	1.0	0.9	2.1	1.5	-0.1	1.2
Crohns Disease (2012)	1.0	1.6	3.0	-0.2	-1.5	-0.9	-1.6	-1.5	-1.7	-0.2	-1.1	-1.6	-1.1
Age when periods started (menarche)	1.0	2.3	4.4	-0.4	-2.1	-0.6	-1.5	-1.9	-2.0	-0.5	-1.5	-2.0	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.9	1.1	0.6	0.9	1.3	0.9	0.7	1.7	1.2	0.6	1.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.1	-0.9	1.4	-0.5	1.3	1.7	1.7	-1.3	0.5	1.8	0.7
Glaucoma (self-reported)	1.0	1.1	2.9	-1.7	-1.2	-1.0	-0.7	-0.9	-0.8	-0.8	-0.8	-1.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.7	0.2	1.4	0.0	0.7	1.7	1.3	-0.2	0.4	1.9	0.7
Medication: Gliclazide	1.0	1.2	2.4	0.4	1.1	1.4	0.8	0.7	0.5	1.6	1.4	1.2	1.3
Medication: Blood pressure	1.0	1.9	4.1	0.1	1.6	0.3	1.9	2.0	1.7	0.6	1.4	1.4	1.2
Myopia	1.0	1.5	4.5	2.1	0.9	0.9	1.2	1.2	1.3	1.5	1.0	0.6	0.9
Impedance of leg (left)	0.9	4.3	15.9	4.0	-0.5	3.3	0.9	0.2	-0.1	3.3	0.9	-0.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.7	1.4	0.5	1.7	1.1	0.4	0.4	2.2	1.1	-0.1	1.3
Illnesses of mother	0.9	1.1	2.1	-0.0	-1.4	-0.5	-1.2	-1.3	-1.1	-0.6	-1.1	-1.5	-1.0
Eye problems/disorders: None of the above	0.9	1.0	2.0	0.8	-1.1	-0.6	-1.4	-0.8	-1.4	-0.4	-1.2	-0.7	-1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	4.5	2.1	0.2	1.8	1.5	0.7	0.6	1.3	0.9	-0.1	1.0
Leg fat mass (right)	0.9	3.4	5.6	0.7	2.3	0.9	2.0	2.4	2.2	1.0	1.7	2.2	1.9
Alcohol intake frequency.	0.9	2.2	4.5	-2.1	-0.7	-2.0	-1.6	-1.2	-0.9	-2.0	-1.2	-0.3	-1.6
Leg pain on walking	0.9	1.1	2.8	-1.4	-0.5	-1.5	-0.9	-1.0	-0.6	-1.7	-1.0	-0.1	-0.5
Average weekly red wine intake	0.9	1.3	3.5	0.7	1.0	1.4	0.8	0.9	0.7	1.9	1.1	1.0	1.5
Leg predicted mass (right)	0.9	4.6	15.4	-3.9	-0.1	-3.6	-1.0	-0.4	-0.0	-3.4	-1.6	0.8	-1.4
Alcohol drinker status: Never	0.9	1.0	1.5	0.2	-1.1	-0.9	-1.2	-1.1	-1.2	-1.1	-0.9	-0.9	-1.2
Cholesterol lowering medication	0.9	1.4	3.3	-0.5	1.7	-0.1	0.6	1.3	1.8	0.5	1.0	1.7	1.1
Intelligence (Savage-Jansen 2018)	0.8	2.5	4.1	2.0	1.5	1.8	1.3	0.6	1.1	1.8	1.9	1.2	1.8
Fasting Glucose	0.8	0.9	2.5	-1.0	-0.8	-1.6	-0.7	-0.9	-0.9	-0.9	-0.5	-0.7	-1.3
Pack years adult smoking proportion	0.8	1.3	3.3	-1.8	-0.9	-1.1	-0.9	-0.6	-0.4	-1.5	-1.1	-1.2	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.2	-0.5	-1.4	-0.2	-1.0	-1.1	-1.1	-0.5	-1.5	-1.3	-0.4
Neuroticism score	0.8	1.6	2.9	0.3	0.8	1.7	1.7	1.2	1.4	1.6	1.2	0.4	1.5
Prospective memory result	0.8	1.0	3.5	-1.9	-0.2	-1.2	-0.6	-0.7	-0.2	-1.6	-0.4	-0.4	-1.2
Standing height	0.8	7.6	14.4	-3.8	-2.4	-3.5	-2.3	-1.9	-1.7	-3.4	-3.5	-1.3	-2.3
Blood clot in the leg (DVT)	0.8	1.0	4.2	-2.1	-0.3	-1.5	-1.1	-0.7	-0.7	-0.4	-0.9	-0.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.6	-0.8	-1.3	0.2	-0.5	-1.3	-1.4	-0.6	-0.7	-1.6	-0.7
Health satisfaction	0.8	1.0	2.6	-0.5	1.4	0.8	1.1	0.6	1.0	1.0	1.6	0.7	0.8
Leg fat-free mass (right)	0.8	4.5	15.2	-3.9	-0.0	-3.5	-0.9	-0.3	0.0	-3.4	-1.5	0.8	-1.3
Irritability	0.8	1.4	3.6	0.4	0.9	1.1	1.9	1.0	1.7	1.1	1.2	0.2	1.3
Supplements: Calcium	0.8	0.9	2.0	-0.3	1.0	-0.5	1.2	1.3	1.4	0.9	1.0	0.7	0.5
Leg fat mass (left)	0.8	3.1	5.2	0.6	2.2	0.8	1.9	2.3	2.1	0.8	1.7	2.2	1.8
Bipolar Disorder or Schizophrenia	0.7	1.7	3.3	-1.8	-1.3	-1.2	-1.1	-0.8	-1.2	-1.6	-1.6	-1.0	-1.2
Angina	0.7	0.9	3.2	-1.8	-0.5	-0.9	-1.0	-1.1	-0.9	-0.8	-0.4	-0.4	-0.6
Leg fat-free mass (left)	0.7	3.5	11.6	-3.4	-0.1	-3.2	-0.7	-0.2	0.1	-3.0	-1.5	0.7	-1.1
Leg predicted mass (left)	0.7	3.5	11.2	-3.3	-0.1	-3.2	-0.7	-0.1	0.1	-3.0	-1.5	0.7	-1.1
Trunk fat mass	0.7	3.2	5.1	0.9	2.1	1.2	1.8	2.3	1.9	1.3	1.7	2.1	2.1
Time employed in main current job	0.7	0.8	1.3	0.9	0.9	0.7	1.2	0.8	0.8	1.0	1.0	0.6	0.7
Father’s age at death	0.7	0.9	2.9	1.7	0.2	1.4	0.9	0.9	0.4	0.9	0.4	-0.2	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.4	-1.1	1.4	0.3	0.8	0.8	1.5	0.4	1.0	1.4	1.1
Pulse wave Arterial Stiffness index	0.7	0.8	3.0	-1.6	0.3	-1.7	-0.0	0.4	0.9	-1.1	-0.5	0.2	-0.5
Exposure to tobacco smoke at home	0.7	0.8	3.8	1.2	0.1	1.9	0.2	-0.1	-0.1	1.1	0.7	0.2	1.0
Comparative body size at age 10	0.7	1.9	3.7	0.3	1.9	1.4	1.3	1.4	1.8	0.7	1.9	1.0	1.0
Pulse wave peak to peak time	0.7	0.8	2.6	1.6	-0.4	1.6	-0.1	-0.5	-1.0	1.0	0.3	-0.2	0.4
Whole body fat mass	0.7	3.0	4.8	0.8	2.2	1.0	1.8	2.2	2.0	1.1	1.7	2.0	1.9
Pulse rate, automated reading	0.7	2.3	3.8	-0.2	1.9	1.1	1.3	1.6	1.8	0.8	1.7	2.0	1.8
Comparative height size at age 10	0.7	3.9	9.8	-3.1	-0.8	-3.0	-2.0	-1.0	-0.4	-2.5	-1.8	-0.6	-2.1
Number of full sisters	0.7	0.9	1.3	-0.8	-1.0	-1.1	-1.1	-0.6	-0.7	-0.9	-1.2	-0.8	-1.1
Hypertension (Self-reported)	0.7	1.8	3.6	0.3	1.5	0.7	1.8	1.9	1.8	0.6	1.3	1.2	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	1.3	0.6	0.8	1.0	0.9	0.9	1.3	0.8	0.2	0.5
Mood swings	0.7	1.2	2.5	1.6	0.6	1.1	1.6	0.8	0.9	1.1	1.1	0.7	1.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.6	0.4	0.7	1.1	0.7	1.3	0.4	1.0	0.5	1.1	1.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.5	0.0	0.9	0.1	0.9	1.3	1.2	0.1	0.1	1.6	1.0
Neuroticism (2016)	0.6	0.9	2.3	1.1	-1.0	-0.2	-0.8	-1.3	-0.8	0.4	-0.5	-1.5	-0.9
BMI	0.6	3.6	7.8	-0.5	2.8	-0.2	1.8	2.3	2.5	-0.2	1.7	2.7	1.6
Height	0.6	12.0	19.2	-4.4	-2.9	-4.0	-3.5	-2.9	-2.3	-4.3	-4.0	-2.1	-3.5
Medication: Levothyroxine sodium	0.6	1.0	5.2	2.3	0.8	0.5	0.6	0.8	0.8	0.8	0.8	0.8	0.5
Qualifications: None of the above	0.6	1.3	2.8	0.9	-1.4	0.2	-1.3	-1.6	-1.7	0.2	-0.7	-1.3	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	5.0	-1.1	-0.9	-1.5	-0.6	-1.0	-0.2	-2.2	-1.3	-0.7	-0.9
Hair/balding pattern: Pattern 4	0.6	1.5	4.4	0.9	0.8	1.0	1.5	2.1	1.1	1.6	1.0	0.5	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.8	0.6	0.5	1.7	0.1	-0.1	0.1	1.4	0.9	0.2	1.0
Angina (self-reported)	0.6	0.8	2.3	-1.5	-0.5	-0.8	-1.1	-1.1	-1.0	-0.7	-0.2	-0.5	-0.7
Medication: Omeprazole	0.6	0.7	2.1	-0.2	0.9	0.5	0.7	1.4	0.7	0.3	0.4	1.5	1.0
Heart disease (mother)	0.6	0.7	2.1	-0.7	1.4	-0.0	0.4	0.5	1.0	0.5	1.2	1.1	0.3
Supplements: Vitamin C	0.6	0.7	2.0	-0.4	-1.4	0.4	-0.5	-0.7	-1.4	0.2	-0.7	-1.2	-0.6
Back pain experienced in last month	0.6	0.9	1.9	-1.4	0.7	-1.4	0.2	1.0	1.0	-1.1	-0.1	1.3	0.3
Average weekly champagne plus white wine intake	0.6	0.9	1.7	1.3	0.6	1.0	0.7	1.1	0.8	1.3	0.4	0.5	1.0
Medication: Bendroflumethiazide	0.6	0.9	1.4	0.3	1.0	1.0	1.0	1.2	0.9	0.7	0.9	0.9	1.1
Risk taking	0.6	0.8	1.9	0.2	1.1	0.8	0.9	0.5	0.7	0.9	1.1	0.9	1.4
Bipolar Disorder (2018)	0.5	0.8	1.6	-0.9	-1.1	-0.3	-0.7	-0.4	-1.2	-1.0	-1.3	-0.7	-0.5
Depressed Affect (Nagel 2018)	0.5	1.1	2.0	0.4	1.0	1.3	1.4	1.1	1.1	1.2	1.3	0.5	0.9
Schizophrenia (2018)	0.5	1.0	2.4	-1.6	-0.8	-1.3	-0.8	-0.4	-0.6	-1.3	-1.1	-0.7	-1.1
Breast Cancer	0.5	1.3	3.6	1.1	1.4	0.6	0.8	0.1	0.7	1.8	1.9	0.8	0.8
HDL Cholesterol	0.5	0.8	5.2	2.3	0.5	0.9	0.4	-0.0	-0.2	1.0	0.7	0.3	0.6
LDL Cholesterol	0.5	0.8	2.8	-1.7	-0.8	-0.7	-1.0	-0.2	-0.4	-0.8	-1.2	-0.4	-0.5
Schizophrenia (2014)	0.5	1.2	2.4	-1.3	-0.7	-1.6	-0.9	-0.0	-0.5	-1.4	-1.3	-0.6	-1.4
Qualifications: CSEs or equivalent	0.5	0.6	3.1	-0.4	-0.5	-1.8	0.1	-0.0	-0.2	-1.2	-0.4	-0.5	-0.8
Body mass index (BMI)	0.5	2.1	4.8	-0.3	2.2	-0.1	1.3	1.9	1.8	0.0	1.4	2.1	1.2
Nervous feelings	0.5	1.0	4.3	-0.1	-1.5	0.5	-0.3	-1.1	-0.8	0.3	-0.7	-2.1	-0.6
Had other major operations	0.5	0.6	2.3	-1.5	0.4	-0.4	-0.5	0.2	0.2	-0.9	-0.3	1.3	0.5
Medication: Cholesterol lowering	0.5	0.8	1.6	1.2	0.5	0.7	1.2	0.9	0.9	1.3	1.0	-0.4	0.4
Arm fat mass (right)	0.5	1.9	3.9	-0.1	1.9	0.2	1.4	1.9	1.7	0.1	1.2	2.0	1.3
Birth weight of first child	0.5	0.9	2.3	-0.0	0.9	1.5	0.7	0.8	0.4	1.1	1.0	1.1	1.1
Gout (self-reported)	0.5	0.7	2.1	-0.4	-0.8	-0.0	-1.5	-1.2	-1.2	-0.3	-0.7	-0.6	-0.8
Medication: Seretide 50 evohaler	0.5	0.6	1.6	-1.0	-1.2	-0.5	0.0	-0.3	-0.8	-0.4	-0.8	-1.3	-0.7
Suffer from ‘nerves’	0.5	0.7	1.6	1.0	0.1	1.2	1.0	0.9	0.7	1.3	0.5	-0.1	0.8
Illnesses of siblings: Diabetes	0.5	0.6	1.9	0.7	0.5	0.8	0.9	0.4	0.2	1.4	1.1	0.3	0.9
Smoking status: Previous	0.5	0.7	2.1	0.6	0.6	0.3	1.0	1.4	0.7	0.6	0.7	0.8	0.9
Long-standing illness, disability or infirmity	0.5	0.8	1.7	0.1	1.1	1.1	1.0	0.8	0.8	0.8	1.3	0.7	0.9
Guilty feelings	0.5	0.7	2.1	0.9	0.2	1.3	0.8	0.2	0.2	1.5	0.9	-0.0	0.8
Ever taken oral contraceptive pill	0.5	0.5	1.1	-0.3	-1.1	0.0	-0.8	-0.9	-0.8	-0.0	-0.8	-1.0	-0.4
Mother’s age at death	0.5	0.6	2.2	1.2	0.2	1.5	0.2	-0.2	-0.5	1.0	0.9	0.3	0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.6	-1.1	1.2	-0.5	0.6	0.3	0.8	-0.2	0.9	1.2	0.6
Diastolic blood pressure, automated reading	0.5	1.5	4.5	-0.4	-1.2	-1.3	-0.9	-0.8	-0.9	-2.1	-1.4	-1.0	-1.3
Pack years of smoking	0.5	0.8	2.6	-1.6	-0.6	-0.8	-0.7	-0.4	-0.2	-1.1	-0.6	-0.9	-1.0
Ulcerative Colitis (UC)	0.4	0.8	3.9	-0.3	0.8	0.8	0.4	1.1	0.4	-0.1	0.0	2.0	1.0
Ovarian Cancer	0.4	0.5	1.1	1.0	0.8	1.0	-0.1	0.0	0.2	0.1	0.6	1.0	0.8
Body Mass Index (BMI) (2010)	0.4	0.6	1.6	-1.3	1.1	0.1	0.0	0.5	1.1	-0.2	0.4	1.0	0.4
Primary Biliary Cirrhosis	0.4	0.6	1.4	-0.9	-0.8	0.1	-0.7	-0.8	-1.2	-0.8	-0.7	-0.6	-0.5
Triglycerides	0.4	0.7	2.9	-1.7	-0.7	-0.9	-0.8	-0.2	-0.3	-0.8	-0.9	-0.7	-0.7
Heel T-Score	0.4	3.4	7.2	2.1	2.4	2.0	1.2	0.5	1.3	1.7	2.7	1.6	1.9
Hypothyroidism (self reported)	0.4	0.9	7.3	2.7	-0.7	0.4	-0.3	-0.1	-0.6	0.2	-0.4	-0.3	-0.3
Hair Pigment	0.4	12.7	18.6	-3.2	-3.5	-4.2	-3.1	-2.8	-2.9	-4.3	-4.0	-3.2	-4.0
Average weekly spirits intake	0.4	0.5	1.8	0.6	0.2	1.4	0.6	0.4	0.3	0.8	0.5	0.5	1.0
Townsend deprivation index at recruitment	0.4	0.5	0.9	0.9	-1.0	-0.2	-0.6	-0.5	-0.9	-0.0	-0.6	-1.0	-0.6
Fed-up feelings	0.4	0.7	1.9	0.7	0.6	1.2	0.6	0.0	0.2	1.4	1.2	0.2	0.7
High blood pressure	0.4	1.0	2.4	-0.1	1.1	0.4	1.4	1.5	1.5	0.3	1.0	0.8	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	1.3	-1.2	0.3	-0.2	-0.9	-1.0	0.6	-0.7	-1.4	0.0
Medication: Atenolol	0.4	0.5	1.5	-1.2	0.8	-0.6	-0.7	-1.0	0.0	-0.5	0.8	0.3	-0.5
Pulse rate	0.4	0.6	3.1	-1.8	0.8	-0.5	0.4	0.4	0.8	-0.7	0.4	0.7	0.3
Loud music exposure frequency	0.4	0.4	2.3	0.7	-0.1	1.5	0.5	0.4	-0.1	0.5	0.0	0.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.9	1.0	-0.2	1.0	0.4	-0.4	-0.6	1.4	0.8	-0.4	0.5
Birth weight	0.4	0.8	3.0	-0.6	1.2	-0.4	0.6	0.8	0.8	-0.3	0.6	1.7	0.8
Shortness of breath walking on level ground	0.4	0.4	1.1	0.1	1.0	0.3	0.3	0.2	0.6	0.5	1.1	0.9	0.7
Illnesses of father: None of the above (group 1)	0.4	0.4	1.7	0.3	0.5	1.3	0.3	0.8	0.4	0.6	0.3	0.6	0.7
Arm fat mass (left)	0.4	1.6	3.3	-0.3	1.8	-0.1	1.2	1.8	1.6	-0.0	0.9	1.8	1.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	-0.1	-1.1	-0.4	-1.4	-1.5	-1.4	-0.4	-1.0	-0.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	3.4	-1.9	0.1	-1.1	-0.7	-0.2	-0.2	-0.0	-0.6	0.2	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	-0.1	-0.9	-0.9	0.2	-0.0	-0.2	-0.8	-1.0	-0.1	-0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	2.0	0.0	0.0	0.0	0.0	0.0	0.0	1.4	1.2	0.0	0.3
Ulcerative Colitis	0.3	0.5	1.5	-0.1	0.1	1.2	0.2	1.2	0.2	0.6	-0.2	0.7	0.9
Allergy or Eczema	0.3	0.7	2.7	1.6	-0.5	0.8	0.2	-0.2	-0.4	1.5	0.0	-0.8	0.4
Lung FVC	0.3	1.6	3.3	-1.8	-1.4	-0.7	-1.1	-1.0	-1.2	-1.3	-1.4	-1.1	-1.3
Tanning	0.3	3.4	7.9	0.0	-2.8	-0.3	-1.7	-1.9	-2.8	-0.3	-2.0	-2.5	-1.3
Hearing difficulty/problems: Yes	0.3	0.5	2.0	-1.4	0.0	-1.1	-0.2	0.0	0.1	-1.0	-0.5	0.1	-0.7
Relative age of first facial hair	0.3	0.6	1.5	1.0	-0.5	1.2	0.9	-0.0	-0.1	1.2	0.6	-1.0	0.4
Systolic blood pressure, automated reading	0.3	0.8	2.0	1.4	0.9	0.2	1.2	1.1	1.2	-0.2	0.9	0.5	0.6
Medication for hormone replacement therapy	0.3	0.3	0.8	0.4	-0.3	-0.9	-0.7	-0.3	-0.2	-0.9	-0.7	-0.0	-0.6
Diabetes (mother)	0.3	0.4	1.3	-0.5	-0.4	-0.8	-0.6	0.1	-0.1	-0.9	-1.2	0.2	-0.2
Severe depression (siblings)	0.3	0.3	0.7	-0.2	0.5	0.2	0.7	0.9	0.8	0.5	0.5	0.6	0.6
Average weekly fortified wine intake	0.3	0.4	1.9	-0.3	-0.0	-1.4	-0.4	-0.4	0.3	-0.9	-0.5	-0.1	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	2.2	-1.5	0.7	-0.7	-0.1	0.2	0.3	-0.3	0.4	0.4	-0.3
Stomach or abdominal pain in last month	0.3	0.3	1.0	-0.3	0.6	-1.0	0.6	0.4	0.8	-0.4	0.2	0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	-0.6	0.8	-0.6	0.3	0.7	0.8	-0.3	0.3	0.8	0.3
Waist circumference	0.3	1.2	2.4	0.0	1.4	-0.1	1.2	1.5	1.6	0.1	0.8	1.3	1.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.5	-0.9	0.3	-0.2	-0.9	-0.7	-0.0	-0.7	-0.8	-0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-0.5	-0.5	0.7	-0.1	-0.5	-0.9	-0.1	0.0	-0.9	-0.4
Pain all over the body in last month	0.3	0.3	0.5	-0.1	0.6	0.4	0.7	0.5	0.3	0.7	0.7	0.7	0.7
Illnesses of siblings	0.3	0.4	0.8	0.9	-0.7	0.8	-0.3	-0.4	-0.7	0.2	-0.1	-0.8	-0.4
Weight	0.3	1.3	3.0	-1.7	1.2	-1.4	0.4	1.1	1.1	-1.2	0.1	1.6	0.4
Alcohol intake versus 10 years previously	0.3	0.4	1.4	0.7	0.5	0.3	0.7	1.2	0.8	0.3	0.4	0.6	0.4
Worrier / anxious feelings	0.3	0.5	1.2	0.3	0.4	1.1	0.9	0.5	0.8	1.0	0.8	0.0	0.8
Falls in the last year	0.3	0.5	1.6	0.2	0.7	-0.0	1.1	1.3	1.0	0.3	0.3	0.5	0.3
Happiness	0.3	0.4	0.7	-0.8	0.8	-0.2	0.6	0.2	0.7	0.1	0.8	0.7	0.3
Breastfed as a baby	0.3	0.3	0.5	-0.1	0.6	0.5	0.6	0.7	0.5	0.7	0.6	0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.6	-0.5	-0.3	-0.9	-1.1	-1.0	-0.7	-0.5	-0.0	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	6.0	2.4	-0.0	0.4	-0.1	0.2	-0.1	0.3	0.1	0.3	0.0
Wheeze or whistling in the chest in last year	0.3	0.6	3.1	-1.7	-0.6	-1.0	-0.2	-0.6	-0.6	-0.4	-0.5	-0.6	-0.3
Emphysema/chronic bronchitis	0.3	0.3	0.9	0.0	0.7	-0.1	0.4	0.6	0.7	1.0	0.2	0.7	0.6
Neck or shoulder pain in last month	0.3	0.4	1.4	-0.8	-0.2	-0.7	-1.2	-0.7	-0.3	-0.6	-0.6	0.3	-0.3
Age at last live birth	0.3	0.5	3.3	-0.2	-0.8	0.3	-0.0	-0.7	-0.3	0.1	-0.1	-1.8	-0.6
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.9	0.6	-0.4	0.8	0.2	0.7	0.5	1.0	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.4	0.4	-0.5	0.7	0.9	0.9	-0.0	0.0	0.6	0.0
Mineral and other dietary supplements	0.3	0.4	1.4	0.2	-0.6	-0.5	-0.7	-0.5	-0.2	-0.9	-1.2	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	3.1	-1.8	-0.5	-0.4	-0.3	-0.4	-0.2	-0.9	-0.7	-0.2	-0.4
Number of self-reported non-cancer illnesses	0.3	0.5	1.9	-1.4	-0.2	-1.1	-0.7	-0.4	-0.1	-0.8	-0.5	-0.1	-0.6
Miserableness	0.3	0.5	3.0	-1.7	-0.4	-0.5	-0.1	-0.4	-0.3	-0.7	-0.5	-0.4	-0.4
Hearing aid user	0.3	0.3	0.9	-0.0	-0.7	0.2	-0.6	-0.4	-0.9	-0.6	-0.8	-0.0	-0.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	-1.0	-0.7	-0.2	-0.1	-0.5	-0.5	-0.3	-0.2	-1.0	-0.8
Ever smoked	0.3	0.5	2.6	-1.6	-0.2	-1.0	-0.1	0.3	-0.0	-1.0	-0.3	-0.3	-0.8
Depression (Nagel 2018)	0.2	0.3	0.8	-0.6	0.4	0.4	0.6	0.1	0.5	0.3	0.9	-0.5	-0.3
HbA1C	0.2	0.2	0.6	0.5	-0.1	0.2	0.7	-0.6	-0.3	0.1	0.8	-0.6	-0.4
Rheumatoid Arthritis	0.2	0.3	1.2	1.1	-0.5	0.7	0.2	-0.2	-0.8	0.3	0.1	-0.4	-0.2
Systolic Blood Pressure	0.2	0.8	3.6	-0.2	-0.7	-1.3	-0.3	-0.5	-0.2	-1.9	-0.7	-0.8	-0.9
Respiratory disease	0.2	0.5	1.8	-0.8	0.5	-0.0	0.5	0.7	0.4	1.4	0.2	0.5	0.8
Number of treatments/medications taken	0.2	0.3	0.7	-0.3	0.8	-0.4	0.4	0.8	0.8	0.2	0.5	0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.8	0.1	-0.4	0.1	-1.1	-1.3	-0.9	-0.7	-0.6	-0.2	-0.1
High blood pressure (mother)	0.2	0.2	0.8	-0.0	0.4	0.1	0.1	0.8	0.5	-0.1	-0.1	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	0.3	-0.4	-0.2	-1.1	-1.0	-0.8	-1.1	-0.8	0.1	-0.1
Allergy	0.2	0.5	2.6	-0.5	0.6	-0.1	-0.1	0.3	0.5	-1.6	0.1	1.0	-0.5
Hip circumference	0.2	1.0	2.2	-1.1	1.2	-0.5	0.8	1.5	1.2	-0.2	0.4	1.4	0.8
Number of live births	0.2	0.3	1.0	1.0	0.4	-0.0	0.6	0.8	0.7	0.0	0.1	0.8	0.3
Noisy workplace	0.2	0.3	0.8	-0.9	0.2	0.3	-0.5	-0.8	-0.5	0.5	0.4	0.4	0.2
Asthma	0.2	0.4	1.6	-0.6	0.5	-0.3	0.5	0.6	0.2	1.3	0.4	0.3	0.7
Tense / ‘highly strung’	0.2	0.3	1.8	0.1	-0.3	1.4	0.2	-0.2	-0.3	0.7	-0.2	-0.3	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	0.3	0.5	0.6	0.4	-0.2	0.1	0.5	0.9	0.1	0.4
High blood pressure (siblings)	0.2	0.3	1.1	-0.9	-0.0	-1.0	-0.2	-0.1	0.1	-0.6	-0.4	-0.1	-0.3
Exposure to tobacco smoke outside home	0.2	0.3	1.3	0.7	-0.1	1.1	0.1	-0.4	-0.1	0.6	0.3	0.1	0.5
Qualifications: College or University degree	0.2	0.6	1.8	0.5	-1.1	-0.1	-0.3	-1.1	-0.9	0.2	-0.6	-1.3	-0.3
Medication: Blood pressure	0.2	0.3	0.7	0.1	0.6	0.6	0.5	0.9	0.8	0.3	0.2	0.6	0.5
Chest pain or discomfort	0.2	0.2	0.7	-0.8	0.7	-0.1	-0.4	-0.2	0.1	0.1	0.4	0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.9	-0.5	-0.6	0.1	-0.2	0.2	-0.3	-0.4	-1.0	-0.1	0.1
Friendships satisfaction	0.2	0.3	0.7	-0.7	0.4	-0.2	0.4	0.8	0.7	0.4	-0.0	0.7	0.6
Commuting to job workplace: Walk	0.2	0.2	0.8	0.7	-0.1	0.4	-0.2	0.4	0.0	0.9	0.0	-0.1	0.3
Medication for cholesterol	0.2	0.2	0.5	-0.1	-0.6	0.6	0.1	-0.6	-0.6	0.5	0.1	-0.7	-0.1
Asthma (self-reported)	0.2	0.3	1.6	-0.6	0.4	-0.2	0.3	0.4	0.0	1.3	0.4	0.2	0.7
Osteoarthritis (self-reported)	0.2	0.3	1.1	-0.4	0.8	-1.1	0.1	0.2	0.4	-0.3	0.7	0.6	-0.3
Medication: Paracetamol	0.2	0.3	0.7	-0.5	0.8	-0.7	-0.3	0.1	0.4	0.2	0.3	0.8	0.1
Medication: Atorvastatin	0.2	0.3	1.4	-0.3	0.5	-1.2	0.1	0.7	0.5	0.3	0.3	-0.0	-0.2
Number of operations (self-reported)	0.2	0.3	0.9	-0.6	0.6	-0.4	0.2	0.4	0.4	0.6	0.4	0.9	0.6
Heart disease (siblings)	0.2	0.2	0.9	-0.9	0.2	-0.2	-0.5	-0.4	-0.5	0.2	0.3	0.1	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.5	0.7	0.2	-0.5	0.2	0.3	0.0	-0.1	0.0	0.4	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.5	-0.5	-0.4	0.6	0.1	-0.2	-0.2	-0.3	-0.1	-0.1
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	-0.5	0.5	0.5	-0.0	0.6	0.1	0.2	-0.2	1.2	0.8
Prostate Cancer	0.1	0.2	0.3	-0.3	0.4	0.6	0.2	0.6	0.5	0.2	0.0	0.5	0.4
Mean Putamen Volume	0.1	0.1	0.5	0.0	0.3	0.1	0.2	-0.0	0.0	0.3	0.7	-0.1	-0.4
Blood Eosinophil Count	0.1	0.5	1.6	-0.1	0.2	0.8	1.3	0.9	0.9	0.8	0.6	-0.3	0.7
Blood Platelet Count	0.1	0.8	1.9	0.7	-1.0	-0.7	-0.6	-0.7	-0.6	-0.9	-0.8	-1.4	-1.1
Blood Red Count	0.1	1.2	3.5	-0.2	-1.8	-0.4	-0.5	-0.2	-1.0	0.2	-1.4	-1.9	-1.2
Blood White Count	0.1	1.1	3.2	-1.0	0.7	-0.5	1.8	1.8	1.4	-0.4	0.4	0.4	0.3
Waist Hip Ratio (WHR)	0.1	0.5	1.1	0.8	-0.9	-0.5	-0.3	-0.9	-0.6	-0.2	-0.7	-1.0	-0.4
Cardiovascular Disease	0.1	0.5	1.7	-0.7	-0.5	-1.3	-0.0	-0.2	0.2	-0.8	-0.6	-0.9	-0.7
Lung FEV1/FVC ratio	0.1	0.5	1.5	1.1	1.2	0.5	0.1	0.1	0.3	0.1	1.1	0.7	0.2
Sensitivity / hurt feelings	0.1	0.2	0.5	0.1	-0.1	-0.1	0.6	0.2	0.7	0.7	0.0	-0.3	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	-0.4	0.5	0.0	0.4	0.0	0.4	0.4	0.8	-0.3	-0.1
Vitamin and mineral supplements	0.1	0.1	0.4	0.5	-0.1	0.0	-0.5	-0.5	-0.3	-0.6	-0.2	0.1	-0.0
Multivitamins +/- minerals	0.1	0.1	0.2	-0.5	0.4	-0.3	0.4	0.3	0.4	0.2	0.3	0.2	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.6	0.2	-0.0	0.8	0.3	0.3	-0.5	0.4	0.5	-0.1	-0.0
Past tobacco smoking	0.1	0.2	0.5	0.7	0.0	0.7	-0.1	-0.6	-0.1	0.5	0.1	-0.1	0.1
Heart attack	0.1	0.1	0.9	0.1	-0.3	-0.1	-0.2	0.0	-0.1	0.3	-0.2	-0.9	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.5	0.6	-0.5	-0.6	-0.4	0.1	-0.2	0.3	0.6	-0.0
Lung cancer (father)	0.1	0.1	0.8	-0.9	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1	0.0	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.9	0.0	0.0	1.0	0.5	0.0	0.0	0.7	0.6	-0.3	0.3
Medication: Paracetamol	0.1	0.1	0.4	0.0	0.2	-0.5	-0.6	-0.6	-0.3	0.0	0.2	0.1	-0.3
Medication: Amlodipine	0.1	0.2	0.5	-0.0	0.5	0.6	0.0	0.6	0.1	-0.1	0.3	0.7	0.2
Number of children fathered	0.1	0.1	0.5	-0.2	0.2	0.3	-0.1	-0.7	-0.4	0.3	0.4	-0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.6	0.6	0.0	-0.4	-0.1	-0.2	0.3	0.5	0.3	-0.8	-0.3
Had major operations	0.1	0.2	0.5	-0.4	-0.2	-0.0	-0.1	-0.5	-0.6	0.7	0.3	-0.4	-0.0
Family relationship satisfaction	0.1	0.1	0.3	0.1	-0.1	-0.0	-0.3	-0.2	-0.1	0.5	-0.0	-0.5	-0.4
Knee pain experienced in last month	0.1	0.1	0.5	-0.1	0.7	-0.0	-0.0	0.1	0.4	0.2	0.5	0.6	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.7	-0.5	-0.5	-0.4	0.2	0.1	-0.1	-0.2	-0.8	-0.1	-0.1
Loneliness, isolation	0.1	0.2	0.9	-1.0	0.2	-0.4	-0.1	0.3	0.6	-0.1	-0.2	0.2	-0.1
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.4	-0.1	-0.4	0.4	0.2	0.1	-0.6	-0.2	0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.8	0.3	-0.2	0.3	-0.6	-0.9	-0.7	0.0	-0.1	0.5	0.2
Osteoporosis (self-reported)	0.1	0.2	0.4	-0.5	-0.4	0.4	-0.7	-0.2	-0.6	0.0	-0.3	-0.2	-0.3
Medication: Aspirin	0.1	0.2	0.4	-0.6	0.4	0.3	0.4	0.3	0.4	0.5	0.5	0.2	0.4
Average weekly beer plus cider intake	0.1	0.2	0.8	-0.1	0.7	0.3	0.4	0.1	0.2	0.2	0.9	0.5	0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.4	0.3	0.2	0.3	0.6	-0.1	0.3	0.6	0.4	0.5	0.3
Ever depressed for a whole week	0.1	0.2	0.8	0.1	-0.5	0.6	-0.1	-0.2	-0.9	0.2	-0.3	-0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	1.0	-0.2	-0.4	-0.5	-0.3	-0.0	-0.2	0.2	-0.3	-1.0	-0.4
Crohns Disease (2017)	0.0	0.0	0.2	-0.4	0.1	-0.1	-0.1	0.1	0.1	0.4	-0.0	0.0	0.2
Major Depression (MDD)	0.0	0.0	0.1	-0.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Taking other prescription medications	0.0	0.1	0.2	-0.2	-0.2	0.4	-0.4	0.2	-0.3	0.1	-0.3	0.0	0.0
Hearing difficulty/problems with background noise	0.0	0.1	0.2	0.2	-0.2	-0.1	0.4	0.5	0.1	0.4	-0.1	-0.2	0.0
Medication: Aspirin	0.0	0.0	0.3	-0.6	0.2	-0.2	-0.0	0.0	0.2	0.1	0.0	-0.0	0.1
High cholesterol (Self-reported)	0.0	0.1	0.5	-0.1	-0.1	0.1	0.1	0.1	0.4	0.3	0.2	-0.7	-0.1
Medication: Lisinopril	0.0	0.0	0.4	-0.6	-0.0	-0.1	0.1	0.0	-0.0	-0.0	0.0	-0.1	0.2

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