TWAS hub - ATF5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1350	0.0550	4.2e-03	0.029	NA	0.026	NA	0.031	6.6e-03	NA	9.4e-03	NA	5.3e-03
2	GTEx	Muscle Skeletal	0.1147	0.0350	2.0e-05	0.092	NA	0.064	NA	0.074	2.8e-09	NA	6.6e-07	NA	8.6e-08
3	GTEx	Skin Sun Exposed Lower leg	0.1810	0.0540	3.4e-05	0.116	NA	0.100	NA	0.106	7.9e-10	NA	1.2e-08	NA	4.4e-09
4	GTEx	Thyroid	0.1610	0.0470	2.2e-04	0.012	NA	0.013	NA	0.018	3.8e-02	NA	3.3e-02	NA	1.6e-02
5	METSIM	Adipose	0.1199	0.0289	7.0e-09	0.052	0.062	0.047	0.062	0.053	2.4e-08	1.3e-09	1.2e-07	1.4e-09	1.8e-08
6	YFS	Blood	0.0474	0.0147	9.6e-06	0.006	0.014	0.011	0.015	0.009	2.8e-03	1.3e-05	9.8e-05	6.1e-06	5.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Impedance of whole body	3.7	18.7	31.7	4.8	5.6	3.0	3.7	5.6	1.8
Medication: Ibuprofen	3.6	4.3	11.0	-0.0	-3.3	-2.4	-1.1	-2.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	8.0	0.4	-2.8	-2.7	-1.0	-2.7	-1.2
Impedance of arm (right)	3.2	15.0	25.1	4.9	4.7	2.5	3.2	5.0	1.6
Impedance of arm (left)	3.2	14.9	24.8	4.5	4.9	2.6	3.3	5.0	1.5
Happiness	3.1	3.8	7.3	-0.0	-2.1	-2.7	-1.4	-2.7	-1.4
Breast cancer (self-reported)	3.1	3.7	7.5	-1.2	-2.7	-1.9	-1.4	-2.7	0.6
Impedance of leg (right)	3.0	14.7	24.0	4.6	4.9	2.8	3.2	4.7	1.5
Alcohol drinker status: Previous	3.0	3.4	10.1	-0.6	-1.5	-2.4	-3.2	-1.1	-0.9
Medication: Atenolol	2.7	3.4	6.9	-0.2	-2.2	-2.6	-2.4	-1.4	-0.9
Impedance of leg (left)	2.7	13.2	21.8	4.4	4.7	2.7	2.8	4.5	1.4
Arm predicted mass (left)	2.6	13.1	25.3	-5.0	-4.2	-1.6	-3.1	-4.7	-1.0
Alzheimer’s Disease (including proxy)	2.4	3.5	9.7	-0.7	3.1	3.0	0.7	-1.1	-0.8
Migraine (self-reported)	2.3	2.8	7.7	-2.2	-2.8	-0.4	-0.3	-1.8	0.9
Arm fat-free mass (left)	2.3	11.6	23.1	-4.8	-3.8	-1.4	-3.0	-4.5	-0.9
Relative age of first facial hair	2.2	4.5	11.5	1.3	3.4	1.1	1.5	3.0	1.1
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.5	-0.4	-1.2	-1.9	-1.1	-2.5	-1.6
Trunk fat-free mass	2.2	12.7	23.4	-4.6	-4.4	-1.4	-3.1	-4.8	-1.1
Pulse wave Arterial Stiffness index	2.2	2.6	4.7	-1.0	-1.6	-2.2	-1.9	-1.3	-1.5
Trunk predicted mass	2.2	12.8	22.8	-4.8	-4.4	-1.4	-3.0	-4.8	-1.0
Pulse wave peak to peak time	2.2	2.6	5.1	1.0	1.6	2.3	1.7	1.3	1.4
Arm fat-free mass (right)	2.1	10.7	22.5	-4.7	-3.6	-1.2	-2.9	-4.2	-0.7
Arm predicted mass (right)	2.1	10.7	24.6	-5.0	-3.5	-1.1	-2.7	-4.3	-0.8
Whole body fat-free mass	2.1	11.9	22.8	-4.8	-4.1	-1.3	-3.0	-4.6	-1.0
Whole body water mass	2.1	11.9	22.7	-4.8	-4.1	-1.3	-2.9	-4.6	-1.1
Alzheimer’s Disease (in father)	1.9	2.0	6.5	0.5	2.5	1.5	0.0	-1.0	-1.4
Exposure to tobacco smoke at home	1.9	2.1	4.2	1.4	0.5	0.0	1.3	2.1	-2.0
Qualifications: O levels/GCSEs or equivalent	1.9	3.1	6.5	-2.0	-2.4	-1.0	-0.9	-2.5	0.7
Supplements: Vitamin C	1.9	2.2	4.7	2.2	1.3	1.2	1.0	1.4	1.5
Leg fat-free mass (right)	1.9	10.3	20.1	-4.5	-3.7	-1.4	-2.8	-4.1	-1.1
Leg predicted mass (right)	1.9	10.2	20.1	-4.5	-3.6	-1.3	-2.8	-4.1	-1.0
Basal metabolic rate	1.9	10.6	19.9	-4.5	-3.8	-1.3	-2.8	-4.3	-1.0
Fractured/broken bones in last 5 years	1.9	2.4	4.1	-0.3	1.7	2.0	1.8	2.0	-0.2
Average weekly champagne plus white wine intake	1.8	2.5	4.8	0.8	2.2	1.8	1.8	1.6	0.6
Myopia	1.8	2.7	10.0	-0.7	3.2	0.3	-1.5	1.6	0.7
Primary Biliary Cirrhosis	1.7	2.4	5.3	1.5	-1.6	0.4	2.3	1.8	1.1
Ulcerative Colitis	1.7	2.5	6.7	0.0	0.3	1.6	2.6	1.8	1.6
Leg fat-free mass (left)	1.7	8.8	19.0	-4.4	-3.3	-1.1	-2.5	-3.8	-0.8
Length of working week for main job	1.7	1.9	5.0	0.3	1.7	1.3	2.2	0.4	-1.2
Mother’s age at death	1.7	2.1	4.5	-0.0	1.2	1.6	2.1	1.4	1.5
Body Mass Index (BMI) (2010)	1.6	2.2	5.4	0.0	-2.0	-2.3	-1.4	-1.5	-0.1
Medication: Co-codamol	1.6	1.8	6.3	1.2	-0.2	-2.5	-1.4	-0.6	-0.9
Multivitamins +/- minerals	1.6	2.0	8.2	1.4	0.6	-0.9	-0.8	-0.5	-2.9
Leg predicted mass (left)	1.6	8.7	18.8	-4.3	-3.3	-1.1	-2.5	-3.8	-0.9
Pulse rate	1.6	2.7	5.1	-1.3	-2.2	-1.4	-1.4	-2.0	-1.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.6	-1.5	-1.9	-1.3	-1.1	-1.4	-0.4
Alzheimer’s Disease (in mother)	1.5	1.8	4.5	-1.4	1.6	2.1	1.1	-0.6	-0.2
Qualifications: CSEs or equivalent	1.5	2.0	5.2	-2.1	0.2	-0.5	-2.3	-1.1	-0.8
Depression (self-reported)	1.5	1.7	5.3	1.4	-0.7	0.8	1.1	0.9	2.3
Leg pain on walking	1.5	1.9	4.3	-0.9	-2.1	-1.1	-0.3	-2.0	0.9
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.1	-0.8	-1.7	-1.8	-1.6	-1.2	0.3
BMI	1.4	7.8	12.7	-3.6	-2.6	-2.5	-2.9	-3.4	-1.1
Relative age voice broke	1.4	2.1	6.8	1.6	2.6	-0.6	-0.0	1.7	0.0
Major Depression (MDD)	1.3	1.6	4.0	-1.7	-1.7	0.0	2.0	-0.1	-0.1
Body mass index (BMI)	1.3	5.4	7.4	-2.7	-2.6	-2.2	-2.5	-2.7	-0.4
Medication: Lansoprazole	1.3	1.5	4.7	2.2	1.1	1.1	0.7	1.1	0.6
Prospective memory result	1.3	1.6	2.5	-1.0	-1.3	-1.0	-1.6	-1.4	-1.1
Pulse wave reflection index	1.3	1.6	3.7	-1.3	-1.2	-1.9	-1.1	-1.1	-0.3
Blood clot in the leg (DVT)	1.3	1.6	6.4	-0.9	-1.5	0.2	-0.6	-2.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.6	2.4	-0.6	-0.8	-1.0	-1.1	0.2
Fed-up feelings	1.2	2.2	4.9	1.7	0.1	-2.2	-1.3	-1.2	-1.5
Weight	1.2	5.9	10.5	-3.2	-2.6	-1.4	-2.5	-3.1	-0.4
Exposure to tobacco smoke outside home	1.2	1.6	3.5	-0.6	0.9	1.2	1.3	1.9	1.4
Health satisfaction	1.2	1.6	4.7	0.1	-1.1	-2.2	-0.8	-1.6	-0.6
Medication for pain relief, constipation, heartburn	1.2	2.0	4.6	0.9	2.1	1.4	-0.3	2.1	-0.5
Prostate Cancer	1.1	1.5	5.0	0.6	1.3	1.0	0.9	-0.5	-2.2
Hearing difficulty/problems: Yes	1.1	1.7	6.0	-0.8	-1.8	0.1	0.0	-2.4	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.9	0.9	0.4	-1.6	-0.2	-0.1	-2.2
Time employed in main current job	1.1	1.3	7.4	0.3	2.7	0.6	0.3	0.2	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	3.5	-1.0	-1.3	-1.3	0.2	-1.6	-1.9
Medication: Allopurinol	1.1	1.5	2.7	-0.4	-0.5	1.6	1.6	1.4	1.3
Pulse rate, automated reading	1.1	3.5	6.2	0.1	-2.5	-2.0	-2.1	-1.8	-1.7
Number of full sisters	1.1	1.3	3.1	-0.8	1.5	0.6	1.2	1.8	0.5
Medication: Paracetamol	1.1	1.7	4.3	0.8	-1.8	-1.0	-1.0	-2.1	-0.4
Age at First Birth	1.0	1.4	4.5	0.0	2.1	0.7	0.4	1.7	-0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.2	1.1	-0.3	0.7	0.4	-1.6	1.8
Ever used hormone-replacement therapy (HRT)	1.0	1.2	4.2	2.0	1.7	-0.4	-0.4	0.3	-0.2
Systolic blood pressure, automated reading	1.0	2.8	6.2	-0.4	-2.2	-2.0	-2.5	-1.0	0.7
Current tobacco smoking	1.0	1.6	3.5	-1.1	-1.6	-0.6	-1.1	-1.9	0.8
Serious illness, injury or assault to yourself	1.0	1.2	2.7	-0.1	-1.6	-1.1	-0.3	-1.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.5	0.8	1.0	1.0	2.1	1.4	0.1
Eye problems/disorders: None of the above	1.0	1.2	3.7	-1.2	1.9	1.3	-0.3	0.6	0.1
Medication: Seretide 50 evohaler	1.0	1.1	4.0	-0.2	2.0	1.2	0.2	0.7	-0.8
Alcohol intake frequency.	1.0	2.3	4.2	-0.9	-2.0	-1.2	-1.9	-1.8	-0.7
Ever had bowel cancer screening	1.0	1.1	2.5	1.6	0.7	1.5	0.6	0.7	0.8
Financial situation satisfaction	1.0	1.2	2.8	-0.0	-0.2	-0.7	-1.1	-1.7	-1.7
High cholesterol (Self-reported)	1.0	1.8	4.9	-0.2	1.5	0.6	0.7	2.2	1.6
Illnesses of father: High blood pressure	1.0	1.2	3.1	-1.7	-0.9	0.3	-0.0	-0.7	1.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.5	0.9	1.3	1.3	1.6	0.3	0.7
Supplements: Calcium	1.0	1.1	3.9	0.4	0.8	-0.5	-1.2	0.2	-2.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	5.0	-1.1	-1.1	0.7	-0.3	-2.2	0.1
Irritable Bowel Disease (IBD)	0.9	2.1	5.8	1.4	-0.3	1.1	2.4	1.7	1.0
Angina	0.9	1.2	4.7	0.7	-2.2	-0.7	-1.1	-0.6	0.3
Vitamin and mineral supplements	0.9	1.3	2.9	-1.7	-1.6	-0.5	-0.2	-0.7	1.1
Pack years adult smoking proportion	0.9	1.4	3.7	-1.9	-1.4	-1.3	0.8	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.2	5.8	1.0	-1.9	-0.1	-0.8	-1.3	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	5.1	1.2	-1.9	0.1	-0.5	-1.4	2.2
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	3.1	0.1	-0.5	0.9	1.4	0.8	1.8
Hip circumference	0.9	3.7	8.5	-2.9	-1.9	-0.9	-1.8	-2.4	-0.4
Falls in the last year	0.9	1.2	4.3	0.7	1.3	0.5	0.5	-0.1	-2.1
Mouth/teeth dental problems: Dentures	0.9	1.6	3.3	1.8	-0.2	-1.8	-1.7	-0.0	-0.3
Illnesses of mother	0.9	1.1	3.0	1.7	0.9	-0.3	-1.2	0.8	0.8
Loud music exposure frequency	0.9	1.0	2.6	0.1	0.0	0.3	1.4	1.1	-1.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.8	0.7	1.9	-0.4	1.2	0.7	-0.5
Headache pain in last month	0.9	1.6	4.3	-1.7	-2.1	-0.2	0.6	-1.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.3	0.5	-0.8	-0.4	-0.8	-1.8	1.0
Shortness of breath walking on level ground	0.9	1.1	2.3	0.3	-1.5	-1.3	-0.0	-0.9	-1.3
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.9	1.0	0.7	1.4	1.4	-0.1	0.9
Emphysema/chronic bronchitis	0.9	1.0	3.6	0.5	0.9	0.9	1.9	0.6	-0.0
Angina (self-reported)	0.9	1.2	4.3	0.8	-2.1	-0.7	-1.1	-0.6	0.4
Age at last live birth	0.9	1.3	4.2	-0.9	1.3	0.4	0.7	0.9	2.0
Average weekly red wine intake	0.9	1.3	4.7	-0.2	2.2	1.0	0.6	0.9	1.0
Long-standing illness, disability or infirmity	0.9	1.4	2.2	0.2	-1.0	-1.2	-1.3	-1.5	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.1	-1.3	0.6	-0.6	-0.5	-1.4	-1.0
Number of self-reported non-cancer illnesses	0.9	1.6	7.8	-0.5	-1.1	-0.2	-0.3	-0.6	2.8
Number of operations (self-reported)	0.9	1.3	3.2	-0.4	1.7	1.8	0.6	-0.9	0.6
Diastolic blood pressure, automated reading	0.9	2.7	6.1	-1.2	-2.0	-1.3	-2.5	-1.7	-0.4
Pack years of smoking	0.9	1.3	2.6	-1.5	-1.4	-1.6	0.5	0.4	0.6
Ulcerative Colitis (UC)	0.8	1.6	6.2	0.9	-0.5	1.1	2.5	0.7	0.9
Type 2 Diabetes (T2D) (2012)	0.8	1.0	5.8	0.0	0.0	0.0	0.0	0.0	2.4
Type 2 Diabetes (T2D) (2018)	0.8	1.4	6.7	-2.6	-0.3	-1.2	0.2	0.1	0.2
Hair/balding pattern: Pattern 2	0.8	1.1	3.8	0.7	-0.4	1.2	0.7	-0.3	1.9
Had other major operations	0.8	1.0	2.3	0.3	-0.2	1.4	1.2	-1.5	-0.0
Medication: Ramipril	0.8	1.0	2.5	0.4	0.4	-0.8	-0.4	1.6	1.5
Qualifications: A levels/AS levels or equivalent	0.8	1.9	4.0	-1.7	-1.8	0.6	0.1	-0.7	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	3.2	-1.1	1.8	-0.5	-0.9	0.5	-0.6
Medication: Cholesterol lowering	0.8	1.3	3.2	-0.1	1.8	0.1	-0.7	1.8	1.0
Arm fat mass (right)	0.8	3.4	6.3	-2.5	-1.8	-1.5	-2.1	-2.0	0.0
High blood pressure (siblings)	0.8	1.1	3.6	-1.9	0.6	0.2	0.4	-0.4	1.6
Comparative body size at age 10	0.8	2.1	3.8	-1.3	-1.1	-1.9	-1.9	-0.9	-1.3
Mean time to correctly identify matches	0.8	1.4	6.1	2.5	1.4	-0.6	0.3	0.4	-0.1
Heart disease (mother)	0.8	1.0	2.9	-0.0	-1.7	-1.1	-0.5	0.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.5	-0.3	0.3	1.3	1.0	-0.4	-1.6
Qualifications: nursing, teaching	0.8	1.3	3.8	-1.9	-1.0	-0.1	-0.1	-1.4	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.1	1.0	0.4	1.4	2.0	-0.4	-0.2
Osteoporosis (self-reported)	0.8	1.0	3.3	1.1	1.8	1.3	-0.0	0.1	0.2
Osteoarthritis (self-reported)	0.8	1.0	2.6	-0.7	-0.8	-1.0	-1.6	-0.7	0.8
Arm fat mass (left)	0.8	3.4	8.0	-2.8	-1.8	-1.3	-2.0	-2.0	0.0
Guilty feelings	0.8	1.2	3.5	1.9	0.5	-0.1	0.9	1.5	0.8
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.4	-0.4	0.3	1.4	1.8	0.2	0.3
Medication: Atorvastatin	0.8	1.0	1.9	-1.0	1.4	-0.5	-0.5	1.4	-0.7
Irritability	0.8	1.4	5.1	-1.2	-0.3	-2.3	-0.9	-0.0	0.9
Basal cell carcinoma (self-reported)	0.8	1.0	2.6	0.5	0.6	-1.6	-1.3	0.8	-0.6
Fasting Glucose	0.7	0.8	2.5	0.6	0.8	-0.6	-1.6	-0.9	-0.6
Neuroticism (2016)	0.7	0.9	3.4	0.7	1.8	0.2	0.1	1.3	-0.5
Rheumatoid Arthritis	0.7	1.0	2.8	-0.6	1.7	1.3	0.1	0.7	0.6
Hypothyroidism (self reported)	0.7	1.7	6.1	2.5	0.2	-0.4	0.4	1.7	-1.0
Lung FEV1/FVC ratio	0.7	3.5	7.1	-1.5	-1.9	-2.7	-1.8	-1.8	-1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.3	1.5	-0.1	-0.7	-0.8	-0.5	-1.0
Supplements: Zinc	0.7	0.8	2.5	1.0	-0.5	-1.0	0.2	-0.3	-1.6
Average weekly fortified wine intake	0.7	0.8	3.1	-1.8	-0.2	-0.0	-0.2	-0.2	1.2
Sitting height	0.7	5.0	10.8	-3.0	-2.9	0.1	-1.4	-3.3	-0.3
Waist circumference	0.7	2.6	8.0	-2.8	-1.1	-1.0	-1.9	-1.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	5.0	2.2	0.0	-0.3	0.4	0.1	0.2
Lung cancer (father)	0.7	0.8	1.8	-0.9	0.9	0.4	1.2	1.3	0.1
Medication: Paracetamol	0.7	1.1	2.7	0.4	-1.4	-0.9	-0.8	-1.6	-0.6
Medication: Gliclazide	0.7	0.8	1.3	0.7	-1.0	-0.9	-1.0	-1.2	0.1
Smoking status: Current	0.7	1.1	2.5	-0.9	-1.5	-0.3	-0.7	-1.6	0.8
Wears glasses or contact lenses	0.7	0.8	2.2	1.1	0.6	-1.0	0.0	1.5	-0.2
Medication: Blood pressure	0.7	1.4	2.6	-1.6	-0.7	-1.5	-1.0	-1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.3	-0.6	-1.0	-0.9	-0.3	-1.8	-0.1
Medication: Bendroflumethiazide	0.7	1.0	2.7	-0.2	0.0	-1.5	-1.1	0.3	1.6
Ever depressed for a whole week	0.7	0.8	1.6	0.9	-0.4	0.9	-0.0	-1.2	1.3
Bipolar Disorder (2018)	0.6	1.0	2.0	-1.4	-1.2	0.5	1.3	-0.7	-0.1
Mean Putamen Volume	0.6	0.7	3.0	-0.2	0.3	-1.7	-1.0	0.2	-0.2
Schizophrenia (2014)	0.6	1.3	4.0	1.1	-0.4	-0.1	1.3	-0.9	-2.0
Triglycerides	0.6	0.9	2.9	0.0	-1.4	-0.3	-0.6	-1.7	0.4
Blood Red Count	0.6	6.0	19.4	-2.0	4.4	1.8	2.0	1.6	1.5
Allergy or Eczema	0.6	1.5	4.5	1.1	2.1	0.4	-0.0	1.4	1.0
Hand grip strength (left)	0.6	1.6	3.5	-1.7	-0.7	-0.1	-0.1	-1.6	-1.9
Number of treatments/medications taken	0.6	1.1	4.0	-0.2	-1.4	-0.8	-0.1	-0.2	2.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.9	-0.4	-1.2	-0.8	0.1	-0.1	-1.7
Townsend deprivation index at recruitment	0.6	0.9	2.4	0.9	1.6	0.3	-0.1	1.0	1.1
Taking other prescription medications	0.6	0.9	3.3	0.4	-0.8	1.0	0.4	-0.2	1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	-0.2	-1.2	-0.1	0.1	-1.2	-0.9
Medication: Levothyroxine sodium	0.6	1.0	3.8	2.0	-0.7	-0.9	-0.2	0.8	-0.7
Hearing difficulty/problems with background noise	0.6	0.9	3.1	0.1	-1.0	-0.0	0.2	-1.8	1.1
Mouth/teeth dental problems	0.6	0.9	3.3	-1.8	-1.1	0.4	-0.5	0.0	0.8
Noisy workplace	0.6	0.8	1.7	0.6	-1.1	-0.8	0.6	-1.3	-0.6
Peak expiratory flow (PEF)	0.6	1.3	4.0	-2.0	-0.9	0.3	-0.4	-1.8	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.8	-0.2	-1.7	-0.9	-0.1	-1.0	-1.4
Birth weight	0.6	1.2	3.1	-0.6	-1.5	-0.1	-0.8	-1.8	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.5	-0.7	-1.0	-0.7	-0.4	-1.6	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.9	-0.0	0.5	-1.1	-1.7	0.0	0.3
Leg fat mass (right)	0.6	2.2	4.8	-2.2	-1.2	-1.1	-2.0	-1.3	0.5
Medication: Aspirin	0.6	0.8	2.8	-1.7	-0.0	-0.4	0.6	0.6	1.2
Illnesses of father: Heart disease	0.6	0.8	1.7	0.5	-0.7	-1.3	-0.5	0.8	1.3
Friendships satisfaction	0.6	0.7	2.0	-0.4	0.3	0.2	1.2	-0.7	-1.4
Age started oral contraceptive pill	0.6	0.7	1.9	-1.4	0.6	0.2	0.2	-0.5	1.3
Cholesterol lowering medication	0.6	0.9	4.8	-2.2	-0.2	0.1	-0.3	0.3	0.6
Leg fat mass (left)	0.6	2.5	5.9	-2.4	-1.2	-1.1	-2.0	-1.5	0.4
Depressed Affect (Nagel 2018)	0.5	1.0	3.3	0.1	0.6	-0.9	-0.9	-0.9	-1.8
Breast Cancer	0.5	1.1	4.4	2.1	0.5	-0.4	-0.9	-0.7	-0.8
LDL Cholesterol	0.5	0.8	2.2	0.0	-1.5	-0.3	-0.8	-1.3	-0.3
Lupus	0.5	0.7	2.2	0.5	-0.6	-1.5	-1.0	0.7	0.1
Systolic Blood Pressure	0.5	2.4	4.5	-1.9	-2.1	-1.1	-1.4	-0.5	1.7
Tanning	0.5	6.7	15.6	-0.2	2.8	4.0	3.2	2.4	0.6
Sensitivity / hurt feelings	0.5	0.8	2.3	-0.1	1.5	0.7	1.2	0.7	0.0
Medication for hormone replacement therapy	0.5	0.5	1.4	0.7	0.4	0.5	0.2	-1.2	0.8
Diabetes (mother)	0.5	0.7	1.4	-1.2	-0.7	0.9	-0.3	-0.5	1.0
Hand grip strength (right)	0.5	1.3	2.4	-1.1	-1.3	0.6	0.5	-1.3	-1.5
Number of incorrect matches in round	0.5	0.8	2.3	0.4	1.2	0.8	-0.2	-0.5	-1.5
Qualifications: None of the above	0.5	1.2	2.7	1.6	0.4	0.3	0.9	1.6	0.7
Illnesses of siblings	0.5	0.6	1.8	0.9	-0.3	-0.2	-0.3	1.0	-1.4
Alcohol intake versus 10 years previously	0.5	0.8	1.4	0.8	0.8	0.7	1.2	0.4	1.1
Worrier / anxious feelings	0.5	1.0	3.7	1.2	-0.0	0.1	0.6	0.7	1.9
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	1.2	-1.3	-1.0	-0.4	0.3	0.7
Medication: Amlodipine	0.5	0.6	1.9	-1.1	0.1	-0.7	0.0	-0.3	1.4
Worry too long after embarrassment	0.5	0.8	2.8	0.4	0.6	0.4	1.7	0.9	-0.6
Qualifications: College or University degree	0.5	1.4	3.6	-0.1	0.7	1.9	1.0	0.6	1.7
Family relationship satisfaction	0.5	0.7	2.5	0.3	0.8	0.3	0.3	0.7	-1.6
Commuting to job workplace: Walk	0.5	0.5	1.9	1.4	0.8	0.1	0.2	0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.5	-1.1	-1.6	-0.5	-0.2	-0.7	1.1
Ever taken oral contraceptive pill	0.5	0.6	1.6	0.4	0.9	0.6	0.4	0.7	-1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	3.3	1.8	-0.1	0.1	-0.5	0.1	0.5
Risk taking	0.5	0.7	2.6	0.4	0.6	0.1	0.6	0.7	1.6
Commuting to job workplace: Cycle	0.5	0.6	1.8	1.0	1.4	0.2	0.2	-0.8	-0.1
Pain experienced in last month	0.5	0.9	4.0	0.3	2.0	0.0	-0.9	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	-0.6	0.7	-0.6	0.4	1.1	1.0
Worry (Nagel 2018)	0.4	0.8	1.4	1.2	1.2	0.3	0.2	1.1	0.8
Crohns Disease (2017)	0.4	0.9	3.2	0.8	0.2	0.5	1.0	1.8	0.2
Reaction Time	0.4	0.8	2.6	1.6	0.1	-1.1	0.0	-0.5	-0.9
Crohns Disease (2012)	0.4	0.6	1.1	0.0	0.9	1.1	0.8	0.9	0.5
HDL Cholesterol	0.4	0.7	1.4	0.0	1.2	0.9	1.0	0.7	-0.7
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.3	0.9	0.1	0.8	0.2	0.9
Medication: Metformin	0.4	0.6	1.9	-1.4	1.1	-0.0	0.7	0.6	0.2
High blood pressure	0.4	1.1	3.1	-0.9	-0.7	-1.1	-0.7	-0.6	1.7
Stomach or abdominal pain in last month	0.4	0.5	1.1	-1.0	-0.1	-0.1	-0.5	-1.1	-0.9
Had menopause	0.4	0.5	2.6	0.7	1.6	0.0	0.1	0.1	0.1
Heart attack	0.4	0.5	1.4	-0.5	0.6	-0.7	0.4	1.2	0.8
Allergy	0.4	0.8	2.5	0.3	-1.0	0.1	-0.4	-1.1	-1.6
Pain all over the body in last month	0.4	0.4	1.4	0.0	-0.3	-0.3	0.4	-1.2	0.9
Diabetes (self-reported)	0.4	0.7	1.7	-1.3	0.9	-0.7	0.1	0.8	-0.7
Medication: Simvastatin	0.4	0.6	2.2	-0.2	0.4	-0.2	-1.5	0.8	0.8
Father’s age at death	0.4	0.5	1.1	-0.1	1.0	0.3	0.6	0.5	-1.0
Breastfed as a baby	0.4	0.6	1.7	0.1	-0.9	-0.2	-0.7	-1.3	-0.5
Tense / ‘highly strung’	0.4	0.6	2.7	-0.1	-0.0	0.8	1.6	0.6	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.5	-0.2	-1.2	-0.7	-1.1	-0.9	0.1
Birth weight of first child	0.4	0.7	1.9	0.9	-1.4	-0.4	0.2	-0.0	-1.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.0	0.7	-0.3	-1.4	-0.2	-0.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.1	1.8	-0.2	-0.6	0.1	0.9	-0.6
Age at first live birth	0.4	0.8	1.9	-1.3	0.1	0.1	-0.2	1.0	1.4
Whole body fat mass	0.4	1.7	4.6	-2.1	-0.9	-0.9	-1.6	-1.0	0.4
Suffer from ‘nerves’	0.4	0.6	3.2	0.5	1.8	-0.1	-0.2	0.3	-0.4
Had major operations	0.4	0.4	2.0	-0.1	-0.3	0.1	-0.7	-1.4	0.1
Illnesses of siblings: Diabetes	0.4	0.4	0.7	0.4	0.7	0.1	-0.8	-0.8	0.9
Smoking status: Previous	0.4	0.6	1.4	1.2	0.3	0.0	0.5	1.0	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.6	-0.8	1.3	0.7	0.2	0.6	0.2
Eye problems/disorders: Cataract	0.4	0.5	1.3	-0.1	-1.1	-0.9	-0.2	-0.6	-0.8
Back pain experienced in last month	0.4	0.6	1.9	-0.4	-1.4	-0.7	-0.5	-0.8	-0.4
Medication: Aspirin	0.4	0.5	1.6	-1.3	0.2	-0.4	0.4	0.7	1.0
Alcohol drinker status: Never	0.4	0.4	2.0	0.1	-0.5	0.5	0.0	0.3	1.4
Average weekly beer plus cider intake	0.4	0.6	1.7	0.6	-0.6	-1.3	0.9	0.7	0.0
Unable to work because of sickness or disability	0.4	0.5	1.9	0.7	0.3	-0.1	1.4	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.6	0.5	0.6	1.2	0.6	0.4	-2.1
Heart disease (siblings)	0.4	0.5	2.2	0.1	1.5	0.1	0.3	-0.3	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.8	-0.5	-1.1	0.4	0.9	-1.3	-0.7
Blood White Count	0.3	2.5	10.8	-3.3	-0.5	-0.8	-1.4	-1.0	-0.3
Heel T-Score	0.3	2.3	6.8	0.4	-1.2	-1.9	-1.2	-0.7	2.6
Smoking Status	0.3	0.8	2.4	-0.7	-0.8	-0.6	-1.0	-1.6	-0.3
Neuroticism	0.3	0.6	1.3	1.1	1.1	-0.8	-0.0	0.3	-0.8
Chronotype (morning person)	0.3	0.6	1.4	-0.6	-1.2	-0.7	0.9	0.5	0.7
Severe depression (siblings)	0.3	0.3	0.7	0.2	0.8	0.8	0.2	-0.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	0.1	-0.2	-0.8	-0.6	-0.8	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	-0.1	1.3	0.1	-0.6	1.2	0.9
High blood pressure (mother)	0.3	0.4	1.0	-0.9	-0.7	0.1	1.0	-0.2	-0.2
Trunk fat mass	0.3	1.2	3.2	-1.8	-0.8	-0.8	-1.2	-0.7	0.7
Alcohol usually taken with meals	0.3	0.5	1.1	-0.7	0.7	0.0	-0.8	1.1	0.4
Number of live births	0.3	0.5	1.2	-0.5	0.1	1.1	0.3	-0.7	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.6	-0.1	-1.9	-0.0	-0.3	-1.6	-0.5
Gout (self-reported)	0.3	0.5	1.5	0.5	-1.2	0.3	0.3	0.5	0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.3	-0.1	-1.0	0.2	-0.3	-1.2	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	2.0	0.1	0.1	0.0	1.4	-0.3	0.4
Number of full brothers	0.3	0.4	0.9	-0.6	-0.6	0.7	0.2	-1.0	0.0
Number of children fathered	0.3	0.3	0.6	-0.6	0.7	0.0	0.8	0.2	0.3
Medication: Blood pressure	0.3	0.5	2.0	0.2	0.7	0.7	-0.1	0.2	1.4
Medication: Omeprazole	0.3	0.4	0.9	0.4	0.4	1.0	0.9	-0.1	0.4
Overall health rating	0.3	0.7	1.8	-1.0	-0.9	-1.3	-0.3	-0.8	-0.2
Hypertension (Self-reported)	0.3	0.8	1.9	-0.5	-0.6	-1.1	-0.9	-0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	1.0	0.6	-0.7	-0.0	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.0	-1.4	-1.2	-0.1	-0.3	-0.4	0.1
Loneliness, isolation	0.3	0.4	1.6	-0.6	-0.2	-0.3	-0.5	-0.0	-1.3
Diabetes diagnosed by doctor	0.3	0.5	2.1	-1.5	0.3	-0.8	0.1	-0.2	-0.3
Medication for cholesterol	0.3	0.4	1.1	1.0	-0.2	0.1	-0.2	0.7	-0.9
Illnesses of father: None of the above (group 1)	0.3	0.3	1.2	-0.4	0.7	0.2	-0.2	0.3	-1.1
Hearing aid user	0.3	0.3	0.8	0.1	-0.5	0.8	0.9	-0.4	-0.1
Commuting to job workplace: Public transport	0.3	0.3	1.7	1.3	0.0	0.3	-0.5	0.1	-0.1
Depression (Nagel 2018)	0.2	0.3	1.5	0.1	-0.4	-0.4	-0.3	0.1	-1.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.1	0.2	-0.4	-0.7	-1.4	0.4	0.6
Neuroticism (Nagel 2018)	0.2	0.4	1.7	0.5	1.3	-0.2	0.0	0.3	-0.6
Schizophrenia (2018)	0.2	0.4	1.2	0.5	-0.4	0.1	0.1	-1.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.7	0.3	-0.2	-0.6	-1.3	0.0	0.1
Ovarian Cancer	0.2	0.2	0.7	0.8	0.8	0.1	0.2	0.2	-0.4
Waist Hip Ratio (WHR)	0.2	1.0	3.8	-0.1	1.9	0.4	-0.4	0.8	1.2
Respiratory disease	0.2	0.4	1.3	-0.5	0.0	-0.3	0.9	0.2	1.1
Maternal smoking around birth	0.2	0.2	0.6	-0.2	-0.4	0.8	0.7	0.0	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	0.4	-0.7	-0.5	0.7	0.3	0.2
Nervous feelings	0.2	0.4	1.8	0.6	0.1	-0.5	0.0	-0.1	1.3
Forced vital capacity (FVC)	0.2	0.7	1.5	-0.5	-1.2	1.0	0.0	-1.2	0.5
Financial difficulties in last 2 years	0.2	0.3	0.8	0.7	-0.9	-0.4	-0.1	-0.0	-0.2
Fluid intelligence score	0.2	0.4	1.3	0.3	0.5	0.2	-1.0	1.1	0.4
Neuroticism score	0.2	0.3	1.6	0.2	0.0	-1.2	-0.4	-0.1	-0.5
Arm fat percentage (right)	0.2	0.7	1.5	-1.0	-0.6	-1.1	-1.2	-0.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.2	-0.6	-1.4	0.6	-0.1	-1.5	0.1
Asthma	0.2	0.4	1.2	-1.1	0.0	-0.5	0.3	0.2	1.0
Hair/balding pattern: Pattern 4	0.2	0.5	2.3	0.2	1.5	-0.2	-0.2	0.6	-0.3
Glaucoma (self-reported)	0.2	0.2	1.0	0.3	0.2	0.3	0.1	-0.4	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.8	2.5	-0.1	-1.6	0.7	0.2	-1.3	0.1
Neck or shoulder pain in last month	0.2	0.3	0.9	-0.8	-0.4	1.0	-0.2	0.1	-0.2
Comparative height size at age 10	0.2	1.0	2.8	-1.0	-0.8	-0.3	-1.7	-0.9	-0.7
Chest pain or discomfort	0.2	0.3	0.7	-0.3	0.3	0.7	0.8	-0.0	0.5
Knee pain experienced in last month	0.2	0.3	1.1	-0.5	-0.1	-0.1	1.0	0.5	0.3
Arm fat percentage (left)	0.2	0.8	1.5	-1.2	-0.4	-1.1	-1.2	-0.3	0.4
Mineral and other dietary supplements	0.2	0.2	0.8	-0.9	-0.1	-0.7	0.3	-0.0	0.2
Asthma (self-reported)	0.2	0.5	1.5	-0.9	-0.2	-0.5	0.5	0.4	1.2
Miserableness	0.2	0.3	1.1	-0.4	-0.4	-0.5	-0.3	-1.1	0.0
Eye problems/disorders: Glaucoma	0.2	0.3	1.0	0.8	-0.1	0.2	-0.1	0.1	-1.0
Medication: Lisinopril	0.2	0.3	1.0	-1.0	0.5	0.1	0.0	-0.4	0.4
Ever smoked	0.2	0.4	1.6	-0.4	-1.3	-0.5	0.4	-0.1	-0.4
Leg fat percentage (left)	0.2	0.6	1.4	-0.7	0.0	-0.9	-1.2	0.0	0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	0.0	0.2	0.8	0.4	-0.3	-0.2
HbA1C	0.1	0.1	0.4	0.0	-0.2	-0.6	-0.2	0.1	-0.5
Blood Eosinophil Count	0.1	0.6	2.2	-0.8	0.1	-0.1	-0.7	1.5	0.3
Blood Platelet Count	0.1	1.2	5.9	-2.4	-0.3	-0.2	-0.7	0.9	-0.2
Height	0.1	2.5	6.4	-1.7	-2.2	0.7	-0.6	-2.5	0.3
Cardiovascular Disease	0.1	0.5	2.5	-0.4	0.0	-0.2	-0.3	-0.1	1.6
Lung FVC	0.1	0.7	1.9	1.0	-1.4	-0.6	0.5	-0.5	0.8
Hair Pigment	0.1	2.9	10.8	-3.3	-0.9	0.5	-1.2	-1.9	-0.5
Diabetes (father)	0.1	0.1	0.5	-0.5	0.0	-0.3	0.7	-0.1	-0.0
Trunk fat percentage	0.1	0.4	1.4	-0.5	0.4	-0.3	-0.3	0.8	1.2
Age when periods started (menarche)	0.1	0.3	0.6	0.0	0.2	0.7	0.8	0.6	0.7
Supplements: Glucosamine	0.1	0.2	0.5	0.5	-0.1	-0.1	-0.2	0.4	-0.7
Past tobacco smoking	0.1	0.2	0.4	-0.5	0.5	0.4	-0.1	-0.3	0.6
Standing height	0.1	1.5	4.2	-2.0	-0.5	1.5	-0.4	-1.4	-0.1
Body fat percentage	0.1	0.5	1.1	-0.6	0.4	-0.6	-0.7	0.6	1.1
Leg fat percentage (right)	0.1	0.5	1.1	-0.5	0.2	-0.9	-1.0	0.2	0.9
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.3	-0.2	-0.2	0.7	0.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	-0.1	0.2	0.3	0.5	0.7	-0.3
Mood swings	0.1	0.1	0.4	-0.7	0.2	-0.0	-0.5	-0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Average weekly spirits intake	0.0	0.0	0.1	0.1	0.1	0.1	0.1	-0.3	-0.1

Hub : Genes

ATF5

Models

Trait associations