[Hub]/) : Traits : Trunk fat-free mass :

chr19:46,276,056-51,224,297

Best TWAS P=1.94e-12 · Best GWAS P=5.01e-19 conditioned to 4.73e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MED25 0.05 0.01 blup 361 0.02 2.2e-03 -6.4 -5.7 1.0e-08 0.03 0.02 0.90 FALSE
2 CommonMind Brain Pre-frontal Cortex PNKP 0.15 0.16 enet 23 0.16 7.0e-19 -5.9 -6.0 2.3e-09 0.03 0.43 0.57 FALSE
3 GTEx Adipose Visceral Omentum PNMAL1 0.18 0.15 lasso 2 0.14 9.7e-08 5.2 5.2 1.6e-07 -0.02 0.00 1.00 FALSE
4 GTEx Cells EBV-transformed lymphocytes SAE1 0.21 0.09 lasso 3 0.07 2.0e-03 -4.4 -5.7 1.6e-08 0.77 0.06 0.67 FALSE
5 GTEx Cells Transformed fibroblasts TBC1D17 0.11 0.03 enet 23 0.04 6.5e-04 -5.5 7.0 1.9e-12 -0.02 0.16 0.82 TRUE
6 GTEx Colon Sigmoid MED25 0.28 0.22 enet 10 0.17 1.2e-06 -6.6 -5.6 2.4e-08 0.07 0.01 0.99 FALSE
7 GTEx Colon Sigmoid PRR12 0.20 0.01 lasso 8 0.00 4.9e-01 3.8 6.3 3.3e-10 0.02 0.04 0.28 FALSE
8 GTEx Colon Transverse PNMAL1 0.35 0.28 lasso 4 0.27 2.0e-13 5.2 5.2 1.7e-07 -0.02 0.00 1.00 FALSE
9 GTEx Esophagus Mucosa AP2A1 0.18 0.09 enet 8 0.13 7.7e-09 -5.8 -7.0 3.3e-12 -0.01 0.02 0.98 FALSE
10 GTEx Muscle Skeletal FUZ 0.09 0.06 enet 9 0.03 3.2e-04 -6.6 -5.5 3.7e-08 0.01 0.00 1.00 FALSE
11 GTEx Muscle Skeletal AKT1S1 0.10 0.09 lasso 3 0.08 1.9e-08 -5.8 5.8 5.7e-09 -0.05 0.46 0.54 FALSE
12 GTEx Nerve Tibial AP2A1 0.16 0.05 lasso 4 0.07 1.3e-05 -6.2 -6.9 4.6e-12 0.02 0.01 0.99 FALSE
13 GTEx Ovary PNMAL1 0.51 0.36 lasso 8 0.34 4.1e-09 5.2 5.2 2.3e-07 -0.01 0.00 0.99 FALSE
14 GTEx Skin Sun Exposed Lower leg CCDC9 0.13 0.00 lasso 5 0.00 2.2e-01 2.4 -5.2 1.8e-07 0.23 0.11 0.21 TRUE
15 GTEx Skin Sun Exposed Lower leg NTN5 0.11 0.09 enet 18 0.05 6.2e-05 -3.9 -5.3 1.1e-07 0.02 0.92 0.06 FALSE
16 GTEx Skin Sun Exposed Lower leg AP2A1 0.15 0.08 enet 10 0.07 1.9e-06 -6.2 -6.2 4.2e-10 -0.01 0.01 0.99 FALSE
17 GTEx Small Intestine Terminal Ileum PNMAL1 0.40 0.00 enet 11 0.15 2.7e-04 5.2 5.5 4.2e-08 -0.01 0.02 0.66 TRUE
18 GTEx Stomach VRK3 0.10 -0.01 enet 10 -0.01 7.3e-01 3.8 6.5 7.7e-11 0.00 0.05 0.40 FALSE
19 GTEx Testis NTN5 0.16 0.02 enet 23 0.06 9.6e-04 -3.7 -6.3 3.4e-10 -0.02 0.02 0.79 TRUE
20 GTEx Testis AC006942.4 0.24 0.03 enet 9 0.10 3.9e-05 -2.8 5.4 5.9e-08 0.00 0.02 0.96 FALSE
21 GTEx Whole Blood PNKP 0.14 0.10 enet 12 0.12 1.5e-11 -5.6 -5.7 1.5e-08 -0.04 0.53 0.47 FALSE
22 METSIM Adipose PNMAL1 0.24 0.27 bslmm 380 0.28 2.9e-41 5.2 5.3 9.2e-08 -0.01 0.00 1.00 FALSE
23 METSIM Adipose SAE1 0.12 0.04 lasso 5 0.07 1.7e-10 -4.1 -6.3 2.9e-10 0.61 0.59 0.41 TRUE
24 YFS Blood PNKP 0.22 0.28 enet 47 0.30 3.9e-101 -5.6 -5.4 6.8e-08 -0.03 0.50 0.50 FALSE
25 YFS Blood SAE1 0.07 0.02 enet 18 0.05 3.6e-16 -8.0 -5.2 2.1e-07 0.56 0.75 0.25 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma AP2A1 0.04 0.03 lasso 4 0.04 1.8e-08 -6.2 6.0 1.5e-09 -0.02 0.01 0.99 FALSE
27 The Cancer Genome Atlas Breast Invasive Carcinoma LIN7B 0.02 0.00 enet 7 0.02 5.1e-05 5.3 -5.6 2.3e-08 -0.04 0.01 0.94 TRUE
28 The Cancer Genome Atlas Breast Invasive Carcinoma MED25 0.01 0.00 blup 47 0.02 2.9e-04 3.6 -5.4 7.1e-08 0.05 0.06 0.69 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma NTN5 0.02 0.01 enet 11 0.01 7.6e-04 -3.9 -5.5 3.3e-08 0.00 0.04 0.74 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma TSKS 0.02 0.02 blup 41 0.03 2.1e-06 -1.9 -5.2 2.5e-07 -0.02 0.65 0.25 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma SNRNP70 0.05 0.02 lasso 3 0.02 2.9e-02 4.1 -5.4 7.9e-08 -0.02 0.02 0.55 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma TBC1D17 0.06 0.03 blup 50 0.02 9.5e-04 -5.6 5.2 1.5e-07 -0.02 0.08 0.87 FALSE
33 The Cancer Genome Atlas Lung Adenocarcinoma PNKP 0.03 0.00 blup 46 0.02 4.0e-03 -5.6 -5.4 6.8e-08 -0.05 0.02 0.09 FALSE
34 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CGB 0.09 0.05 enet 3 0.06 5.3e-07 -4.1 -5.1 3.0e-07 -0.04 0.00 1.00 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GRLF1 0.04 0.04 blup 51 0.03 7.0e-05 4.8 6.0 2.5e-09 -0.04 0.43 0.09 TRUE
36 The Cancer Genome Atlas Thyroid Carcinoma IL4I1 0.07 0.01 blup 63 0.03 7.6e-04 -5.8 5.3 1.0e-07 -0.02 0.03 0.71 FALSE