Hub : Genes

AC006942.4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0829 0.0305 0.00051 0.027 NA 0.013 NA 0.018 0.00097 NA 1.6e-02 NA 0.0061
2 GTEx Testis 0.2360 0.0860 0.00120 0.033 NA 0.099 NA 0.088 0.01300 NA 3.9e-05 NA 0.0001

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.2 0.4 0.5
Bipolar Disorder or Schizophrenia 0.2 0.4 0.6 -0.8 0.5
Depressed Affect (Nagel 2018) 0.9 1.8 2.6 1.0 -1.6
Depression (Nagel 2018) 0.4 0.6 1.2 0.1 -1.1
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.3 2.1 -0.4
Neuroticism (Nagel 2018) 2.7 6.4 9.8 1.8 -3.1
Schizophrenia (2018) 0.4 0.8 1.6 -1.3 0.1
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 -0.8 -0.0
Worry (Nagel 2018) 3.3 6.9 10.2 1.9 -3.2
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 -0.7 0.3
Alzheimer’s Disease (in father) 0.7 0.7 0.9 -0.8 0.9
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 -0.3 0.6
Crohns Disease (2017) 0.0 0.1 0.2 -0.1 -0.4
Irritable Bowel Disease (IBD) 0.0 0.0 0.0 -0.1 0.1
Ulcerative Colitis (UC) 0.2 0.3 0.4 -0.4 0.6
Major Depression (MDD) 0.0 0.0 0.0 -0.2 0.0
Reaction Time 0.1 0.2 0.3 -0.5 -0.5
Verbal and Numeric Reasoning (VNR) 0.8 1.8 2.6 1.6 -1.0
Breast Cancer 0.3 0.7 1.1 1.1 0.4
Ovarian Cancer 1.1 1.4 2.3 1.5 0.7
Prostate Cancer 0.2 0.2 0.3 -0.4 -0.6
Age at First Birth 3.7 5.4 5.5 2.4 -2.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 -0.8 -0.2
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.1 0.2 0.4 0.2 0.6
Mean Putamen Volume 0.2 0.2 0.4 0.6 0.3
Fasting Glucose 1.1 1.3 1.6 -1.0 1.3
HbA1C 1.1 1.2 1.5 1.2 1.0
HDL Cholesterol 0.8 1.4 2.7 1.6 0.3
LDL Cholesterol 0.5 0.8 1.5 -1.2 0.3
Lupus 0.3 0.5 0.6 0.8 0.6
Neuroticism (2016) 0.4 0.5 1.1 1.0 -0.0
Primary Biliary Cirrhosis 0.5 0.7 0.9 -1.0 0.7
Rheumatoid Arthritis 0.1 0.2 0.3 0.1 -0.6
Schizophrenia (2014) 0.6 1.3 2.5 -1.6 0.1
Triglycerides 0.9 1.5 2.9 -1.7 -0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.3 0.4 0.8 0.0 -0.9
Blood Eosinophil Count 0.3 2.2 4.5 -0.1 -2.1
Blood Platelet Count 0.0 0.4 0.5 0.6 -0.7
Blood Red Count 0.2 1.7 2.9 -0.7 -1.7
Blood White Count 0.3 2.2 2.6 -1.6 -1.3
Heel T-Score 0.4 3.4 6.3 2.5 -0.7
BMI 0.3 1.6 3.1 -1.8 0.3
Height 0.8 15.2 20.0 -3.2 4.5
Waist Hip Ratio (WHR) 0.1 0.2 0.2 0.5 0.5
Systolic Blood Pressure 0.1 0.7 0.9 -0.9 0.7
Smoking Status 0.4 0.8 1.2 -0.7 1.1
Allergy or Eczema 0.6 1.6 2.4 0.9 -1.5
Cardiovascular Disease 0.3 0.9 1.7 -1.3 -0.1
Hypothyroidism (self reported) 0.4 1.0 1.1 -1.0 -1.0
Respiratory disease 0.3 0.7 0.7 -0.8 -0.8
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.2 0.8 -1.5
Lung FEV1/FVC ratio 0.1 0.7 0.9 1.0 0.7
Lung FVC 0.0 0.2 0.5 -0.1 0.7
Neuroticism 4.8 11.5 13.0 3.2 -3.6
Chronotype (morning person) 0.2 0.5 0.9 0.4 -0.9
Hair Pigment 0.2 6.6 7.1 -2.7 2.5
Tanning 0.1 1.0 1.8 1.4 -0.3
Hand grip strength (left) 1.2 3.1 6.1 -0.3 2.5
Number of treatments/medications taken 0.1 0.2 0.2 -0.4 -0.4
Average weekly spirits intake 1.2 1.5 3.1 1.8 -0.0
Sensitivity / hurt feelings 0.7 1.2 2.3 -0.2 -1.5
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.0 -0.5
Hearing difficulty/problems: Yes 1.4 2.1 3.5 -0.8 1.9
Relative age of first facial hair 1.2 2.5 4.3 0.8 -2.1
Other serious medical condition/disability diagnosed by doctor 3.8 4.9 6.2 -2.5 1.9
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 0.4 -0.2
Ever had hysterectomy (womb removed) 0.2 0.3 0.4 -0.4 -0.6
Systolic blood pressure, automated reading 0.1 0.3 0.5 -0.3 -0.7
Eye problems/disorders: Diabetes related eye disease 3.4 3.7 5.3 1.4 -2.3
Angina 0.8 1.0 2.0 -0.2 1.4
Medication for hormone replacement therapy 0.6 0.6 0.8 -0.6 0.9
Vitamin and mineral supplements 1.4 1.9 2.9 1.7 1.0
Supplements: Zinc 0.4 0.4 0.5 0.6 -0.7
Medication: Co-codamol 1.3 1.5 3.1 0.1 -1.8
Medication: Metformin 4.3 6.0 10.5 1.3 -3.2
Diabetes (father) 2.3 2.8 5.6 0.2 -2.4
Diabetes (mother) 0.1 0.2 0.4 -0.0 0.6
Severe depression (siblings) 0.1 0.1 0.1 -0.3 -0.1
Pack years adult smoking proportion 0.3 0.4 0.8 -0.9 -0.1
Impedance of leg (right) 2.5 12.2 13.6 3.3 -3.7
Leg fat-free mass (left) 1.9 9.9 11.7 -3.4 2.8
Trunk fat percentage 1.2 4.8 8.2 1.2 -2.9
Hand grip strength (right) 2.2 5.9 11.4 -0.6 3.4
Townsend deprivation index at recruitment 0.1 0.2 0.3 -0.2 -0.6
Current tobacco smoking 3.2 5.3 6.3 -2.1 2.5
Average weekly fortified wine intake 1.1 1.3 2.2 -1.5 0.7
Maternal smoking around birth 1.0 1.5 1.7 1.1 1.3
Fed-up feelings 0.5 0.9 1.6 1.3 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.9 0.3 -2.0
Relative age voice broke 4.3 6.6 9.0 2.0 -3.0
Taking other prescription medications 0.0 0.0 0.1 -0.1 -0.2
Age when periods started (menarche) 0.3 0.8 0.9 0.9 1.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.1 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 1.7 1.3 1.2
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 1.0 1.0 -1.0
Qualifications: CSEs or equivalent 0.4 0.6 1.1 -1.1 0.1
Serious illness, injury or assault to yourself 0.9 1.1 2.0 -1.4 0.4
High blood pressure 0.6 1.6 1.7 -1.2 -1.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.3 1.2 -0.7
Multivitamins +/- minerals 1.1 1.5 2.8 -1.7 -0.3
Stomach or abdominal pain in last month 0.7 0.8 1.6 -1.3 0.3
Supplements: Glucosamine 1.5 2.0 2.5 1.2 -1.6
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.1 -1.1 0.8
Medication: Atenolol 1.2 1.6 3.0 0.3 1.7
Medication: Levothyroxine sodium 1.1 1.8 2.0 -1.3 -1.4
Sitting height 2.0 14.4 21.0 -2.8 4.6
Chronic bronchitis/emphysema (father) 0.5 0.6 1.0 1.0 -0.4
High blood pressure (mother) 0.1 0.1 0.2 -0.3 -0.4
Body mass index (BMI) 0.1 0.4 0.9 -0.9 0.1
Impedance of leg (left) 2.3 11.0 11.6 3.4 -3.2
Leg predicted mass (left) 1.9 9.9 12.1 -3.5 2.8
Trunk fat mass 0.2 0.7 1.4 -0.1 -1.2
Waist circumference 0.1 0.4 0.7 -0.8 -0.2
Number of incorrect matches in round 0.1 0.2 0.4 -0.1 -0.6
Past tobacco smoking 0.1 0.2 0.2 0.3 -0.4
Alcohol usually taken with meals 1.1 1.8 3.2 0.6 -1.8
Nervous feelings 0.8 1.5 1.5 1.2 -1.2
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.2 5.1 1.1 -2.3
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.4 -0.3
Hair/balding pattern: Pattern 2 0.0 0.1 0.1 0.3 -0.0
Had menopause 1.7 2.1 3.6 0.7 -1.9
Had other major operations 1.6 2.0 3.4 -0.7 1.8
Forced vital capacity (FVC) 1.6 6.4 10.3 -1.6 3.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 1.6 0.8 1.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.8 0.9 0.2
Qualifications: None of the above 0.3 0.7 1.4 1.2 -0.2
Financial difficulties in last 2 years 0.8 1.1 1.2 1.0 -1.1
Mouth/teeth dental problems 2.8 4.4 6.2 -2.5 1.6
Heart attack 0.3 0.3 0.4 0.6 -0.6
Allergy 0.3 0.6 1.2 -0.3 1.1
Pain all over the body in last month 0.4 0.4 0.5 -0.7 -0.5
Diabetes (self-reported) 1.8 2.8 4.1 1.2 -2.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 1.0 0.2
Medication: Ramipril 6.8 8.7 17.4 -0.2 -4.2
Medication: Simvastatin 1.7 2.4 4.8 -0.2 -2.2
Fluid intelligence score 0.8 1.7 2.3 1.1 -1.5
Illnesses of siblings 0.9 1.3 2.2 1.5 -0.5
Neuroticism score 1.7 3.6 5.5 1.3 -2.3
Weight 0.7 3.3 4.4 -2.1 1.5
Impedance of arm (right) 2.7 12.8 18.8 2.6 -4.3
Arm fat percentage (right) 0.4 1.5 3.0 0.2 -1.7
Trunk fat-free mass 4.2 24.1 29.4 -4.3 5.4
Hip circumference 0.2 1.0 2.0 -1.4 0.1
Time employed in main current job 0.3 0.3 0.6 0.1 -0.8
Alcohol intake versus 10 years previously 1.3 2.0 3.7 -0.5 -1.9
Father’s age at death 2.0 2.7 3.5 1.3 -1.9
Worrier / anxious feelings 0.9 1.6 2.5 0.9 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 -0.0 0.4
Falls in the last year 1.4 1.9 2.8 -1.7 -1.0
Hair/balding pattern: Pattern 3 0.7 1.1 2.1 -0.3 1.5
Number of live births 0.4 0.6 1.2 -1.1 -0.1
Forced expiratory volume in 1-second (FEV1) 1.7 5.7 10.4 -1.0 3.2
Pulse rate 0.1 0.1 0.3 0.0 0.5
Happiness 0.7 0.8 1.4 0.4 1.2
Noisy workplace 0.8 0.9 1.7 0.5 1.3
Qualifications: A levels/AS levels or equivalent 0.9 2.0 3.5 -0.7 1.9
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 1.3 1.1 -1.0
Mouth/teeth dental problems: Dentures 2.9 4.9 6.8 1.7 -2.6
Asthma 0.1 0.2 0.2 -0.5 -0.4
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.3 8.1 -0.8 2.8
Medication: Cholesterol lowering 1.9 3.0 5.9 -0.2 -2.4
Depression (self-reported) 2.5 3.0 3.7 1.9 -1.5
Medication: Lansoprazole 3.9 4.4 6.5 1.5 -2.6
Prospective memory result 1.1 1.3 2.1 -0.8 1.4
Lung cancer (father) 0.4 0.5 0.7 -0.6 -0.8
Illnesses of mother 0.3 0.3 0.3 0.6 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.5 8.2 -0.9 2.9
Pulse wave Arterial Stiffness index 2.8 3.3 6.1 -2.5 0.7
Impedance of arm (left) 3.1 14.5 22.2 2.6 -4.7
Arm fat mass (right) 0.1 0.4 0.7 -0.8 -0.2
Trunk predicted mass 4.1 23.7 29.3 -4.2 5.4
Standing height 1.1 10.9 12.0 -3.1 3.5
Length of working week for main job 0.3 0.4 0.7 0.0 -0.9
Exposure to tobacco smoke at home 1.3 1.5 2.4 1.5 -0.8
Breastfed as a baby 0.0 0.0 0.0 0.0 -0.1
Tense / ‘highly strung’ 0.5 0.9 0.9 0.9 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 4.0 2.0 -0.5
Hair/balding pattern: Pattern 4 1.3 3.0 6.0 0.2 -2.5
Birth weight of first child 0.9 1.5 2.9 1.7 -0.5
Peak expiratory flow (PEF) 2.4 5.6 9.6 -1.3 3.1
Pulse wave reflection index 3.4 4.2 6.5 -2.5 1.4
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.6 0.8 -0.2
Loud music exposure frequency 0.9 1.0 1.6 0.7 -1.3
Qualifications: O levels/GCSEs or equivalent 1.4 2.2 4.2 -2.1 0.3
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 1.8 0.8 -1.3
Blood clot in the leg (DVT) 1.1 1.4 2.0 -1.4 0.9
Medication: Paracetamol 0.6 1.0 1.6 0.5 1.3
Headache pain in last month 1.8 3.2 4.1 -1.5 2.0
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 3.1 1.1 1.8
Glaucoma (self-reported) 0.9 1.1 1.7 -1.3 0.7
Gout (self-reported) 1.0 1.3 1.6 1.3 1.0
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.2 -1.1 -0.8
Medication: Amlodipine 0.1 0.1 0.2 -0.2 -0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 -0.4 0.3
Birth weight 0.4 0.8 1.0 -0.8 1.0
Chronic bronchitis/emphysema (mother) 1.8 2.1 2.7 1.6 -1.3
High blood pressure (siblings) 0.7 1.0 1.9 -1.4 0.0
Forced vital capacity (FVC), Best measure 1.4 5.2 9.0 -1.2 3.0
Body fat percentage 1.2 4.8 8.3 1.1 -2.9
Leg fat percentage (right) 1.2 4.4 7.4 1.2 -2.7
Arm fat-free mass (right) 2.5 13.0 15.4 -3.3 3.9
Exposure to tobacco smoke outside home 0.3 0.5 0.5 0.6 -0.7
Comparative body size at age 10 0.9 2.4 4.8 -0.2 -2.2
Number of full brothers 1.8 2.2 4.2 -0.4 2.1
Worry too long after embarrassment 3.0 5.0 5.1 2.3 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.7 0.8 0.0
Wheeze or whistling in the chest in last year 0.3 0.6 0.9 -0.5 1.0
Number of children fathered 0.5 0.6 0.7 0.9 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.2 2.3 0.4 1.5
Age at first live birth 0.2 0.4 0.7 0.9 -0.2
Pulse wave peak to peak time 2.6 3.1 5.9 2.4 -0.5
Health satisfaction 0.5 0.6 1.2 -0.1 -1.1
Shortness of breath walking on level ground 0.8 1.0 1.4 1.2 0.7
Qualifications: College or University degree 0.4 1.3 2.2 1.5 0.5
Eye problems/disorders: None of the above 0.2 0.2 0.4 -0.1 0.6
Mouth/teeth dental problems: Loose teeth 2.3 2.7 3.1 1.8 -1.6
Emphysema/chronic bronchitis 0.4 0.5 0.8 -0.9 -0.4
Medication for pain relief, constipation, heartburn 1.0 1.7 2.7 0.9 -1.6
Neck or shoulder pain in last month 0.6 0.8 1.5 -0.3 1.2
Medication: Blood pressure 0.5 0.8 0.9 -0.9 -1.0
Angina (self-reported) 0.7 1.0 1.9 -0.2 1.4
Migraine (self-reported) 4.5 5.6 8.9 -1.5 3.0
Medication: Ibuprofen 3.7 4.4 8.2 -0.8 2.9
Medication: Allopurinol 0.8 1.1 2.1 -0.1 1.5
Medication: Omeprazole 0.3 0.4 0.7 -0.8 -0.4
Medication: Seretide 50 evohaler 0.2 0.2 0.3 -0.4 -0.5
Mean time to correctly identify matches 0.8 1.5 2.9 -0.2 -1.7
Heart disease (mother) 0.1 0.2 0.3 -0.3 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.0 -0.4
Whole body fat mass 0.1 0.6 1.1 -0.3 -1.1
Leg fat mass (right) 0.2 0.8 1.4 -0.4 -1.2
Arm predicted mass (right) 2.7 13.8 16.2 -3.4 4.0
Pulse rate, automated reading 0.1 0.2 0.4 0.7 0.2
Alcohol intake frequency. 1.4 3.3 4.0 -1.6 2.0
Comparative height size at age 10 1.2 6.5 7.7 -2.8 2.3
Number of full sisters 1.0 1.2 2.5 -1.6 0.1
Suffer from ‘nerves’ 1.7 2.6 4.8 0.7 -2.2
Overall health rating 1.0 2.1 4.2 0.0 -2.1
Chest pain or discomfort 0.8 1.1 2.2 -0.0 1.5
Had major operations 0.0 0.0 0.1 -0.1 -0.3
Age at last live birth 0.6 0.8 1.2 0.7 -1.1
Family relationship satisfaction 0.1 0.1 0.1 0.4 -0.3
Leg pain on walking 1.6 2.0 3.6 -0.7 1.9
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.1 4.0 -2.0 -0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.2 0.4
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.0 -0.0 -0.1
Medication: Aspirin 0.2 0.3 0.4 0.3 -0.7
Supplements: Vitamin C 0.1 0.1 0.2 -0.2 -0.5
Knee pain experienced in last month 0.2 0.3 0.5 -0.2 -0.7
Hypertension (Self-reported) 0.6 1.8 2.5 -1.0 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 3.0 0.1 -1.7
Illnesses of father: Heart disease 0.2 0.3 0.4 -0.3 0.6
Illnesses of siblings: Diabetes 0.2 0.3 0.3 0.5 -0.6
Smoking status: Previous 0.1 0.1 0.2 0.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.2 -1.5 1.4
Whole body fat-free mass 3.3 19.0 21.0 -4.1 4.6
Leg fat-free mass (right) 2.2 11.8 12.2 -3.5 3.4
Arm fat percentage (left) 0.6 2.6 5.2 0.2 -2.3
Average weekly red wine intake 1.3 2.0 3.6 1.9 -0.6
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.3 -1.5 -0.6
Mood swings 1.0 1.7 3.0 0.7 -1.7
Loneliness, isolation 0.6 0.8 1.6 -1.3 -0.1
Long-standing illness, disability or infirmity 0.5 0.8 1.1 0.7 -1.0
Ever had bowel cancer screening 1.3 1.5 2.9 -0.4 -1.7
Diabetes diagnosed by doctor 1.3 2.2 4.3 0.3 -2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.8 -0.9 0.5
Friendships satisfaction 0.4 0.5 0.9 -1.0 -0.3
Qualifications: nursing, teaching 0.3 0.5 0.9 -1.0 0.3
Commuting to job workplace: Walk 0.3 0.4 0.7 -0.2 -0.8
Eye problems/disorders: Cataract 0.2 0.3 0.4 0.4 0.7
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.4 0.6 1.6
Medication for cholesterol 0.2 0.3 0.4 0.4 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.5 0.5 -0.7
Back pain experienced in last month 1.2 1.8 3.1 -1.8 0.6
Mineral and other dietary supplements 0.2 0.2 0.3 -0.3 0.6
Breast cancer (self-reported) 1.3 1.5 2.8 -1.7 -0.5
Asthma (self-reported) 0.0 0.1 0.1 -0.2 -0.3
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.0 0.1
Osteoarthritis (self-reported) 0.5 0.6 0.9 -0.6 0.9
Medication: Aspirin 0.5 0.6 0.9 0.5 -1.0
Medication: Gliclazide 0.4 0.5 0.9 1.0 -0.2
Illnesses of father: None of the above (group 1) 1.6 2.0 3.8 0.4 -1.9
Smoking status: Current 3.0 4.8 5.7 -2.0 2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 0.3 0.6
Whole body water mass 3.3 19.1 21.3 -4.1 4.6
Leg predicted mass (right) 2.3 12.0 12.5 -3.5 3.4
Arm fat mass (left) 0.2 0.7 1.3 -1.1 -0.2
Number of self-reported non-cancer illnesses 0.8 1.3 2.3 -1.5 0.6
Average weekly champagne plus white wine intake 0.8 1.1 2.1 0.2 -1.4
Miserableness 0.0 0.1 0.2 -0.0 0.4
Guilty feelings 1.0 1.5 2.0 1.4 -1.0
Wears glasses or contact lenses 0.9 1.1 1.8 0.6 -1.3
Ever taken oral contraceptive pill 0.1 0.1 0.1 0.4 0.1
Hearing aid user 0.0 0.0 0.1 0.0 0.3
Mother’s age at death 1.4 1.8 3.5 1.9 -0.3
Financial situation satisfaction 1.4 1.7 3.3 1.8 -0.4
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.5 -0.7 0.7
Commuting to job workplace: Public transport 0.7 0.8 1.5 1.2 -0.4
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -1.0 0.1
Medication: Blood pressure 0.2 0.3 0.5 -0.3 -0.7
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.7 -0.8 0.8
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.4 0.4 0.7
High cholesterol (Self-reported) 0.5 0.8 1.6 -0.1 -1.3
Medication: Bendroflumethiazide 0.5 0.7 1.5 -0.0 -1.2
Medication: Paracetamol 0.4 0.7 1.3 -0.2 1.1
Medication: Lisinopril 0.0 0.1 0.1 -0.3 0.0
Medication: Atorvastatin 0.7 0.9 1.3 -1.2 -0.6
Illnesses of father: High blood pressure 4.2 5.2 5.8 -2.1 2.4
Alcohol drinker status: Never 0.5 0.6 1.1 -0.2 1.1
Ever smoked 0.4 0.6 1.1 -1.0 0.4
Basal metabolic rate 2.6 14.1 14.9 -3.7 3.9
Leg fat percentage (left) 1.0 3.7 5.6 1.3 -2.4
Arm fat-free mass (left) 2.8 14.3 17.9 -3.3 4.2
Number of operations (self-reported) 0.6 0.9 1.7 -1.3 0.2
Average weekly beer plus cider intake 0.1 0.2 0.3 0.6 0.1
Irritability 1.3 2.2 4.4 0.2 -2.1
Risk taking 0.3 0.4 0.8 0.9 0.2
Ever had prostate specific antigen (PSA) test 3.0 3.5 5.2 -2.3 1.3
Fractured/broken bones in last 5 years 0.1 0.1 0.3 0.1 0.5
Age started oral contraceptive pill 0.3 0.3 0.7 -0.8 -0.0
Diastolic blood pressure, automated reading 0.2 0.7 0.8 -0.8 0.9
Ever depressed for a whole week 0.4 0.5 0.9 0.9 0.3
Unable to work because of sickness or disability 1.7 2.2 3.3 -1.0 -1.8
Commuting to job workplace: Cycle 1.3 1.6 2.6 0.7 -1.6
Myopia 1.2 1.7 3.1 -0.6 -1.8
Vascular/heart problems diagnosed by doctor 0.6 1.6 2.1 1.0 1.5
Cholesterol lowering medication 0.1 0.2 0.2 -0.5 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.4 0.6 -0.7
Pain experienced in last month 0.2 0.3 0.3 0.6 -0.5
Supplements: Calcium 1.6 1.8 2.7 -1.6 -0.9
Basal cell carcinoma (self-reported) 3.1 3.6 7.2 -0.3 -2.7
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.0 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.3 -1.5 0.4
Heart disease (siblings) 0.2 0.3 0.4 -0.2 0.7
Alcohol drinker status: Previous 1.1 1.2 2.4 -1.6 0.1
Pack years of smoking 0.1 0.1 0.2 -0.5 -0.0
Impedance of whole body 3.5 17.7 22.9 3.5 -4.8
Leg fat mass (left) 0.1 0.5 0.9 -0.4 -0.9
Arm predicted mass (left) 3.1 15.5 20.0 -3.3 4.5