[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr11:64,663,227-69,549,801

Best TWAS P=1.31e-38 · Best GWAS P=2.46e-35 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
27	GTEx	Esophagus Muscularis	RAD9A	0.25	0.26	lasso	2	0.26	6.2e-16	-12.4	-13.0	1.3e-38	0.99	0.00	1.00	TRUE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC87	0.03	0.02	blup	34	0.02	2.0e-03	6.1	7.1	1.0e-12	-0.13	0.02	0.73	TRUE
80	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS6KB2	0.17	0.13	lasso	2	0.12	1.2e-03	6.5	-6.3	3.1e-10	0.14	0.00	0.92	TRUE
54	METSIM	Adipose	CTD-3074O7.12	0.12	0.12	bslmm	265	0.12	4.2e-18	5.3	-6.0	1.5e-09	0.24	0.46	0.54	TRUE
28	GTEx	Esophagus Muscularis	MRGPRF	0.09	0.01	lasso	3	0.01	1.3e-01	-5.5	6.0	1.9e-09	0.02	0.03	0.78	TRUE
33	GTEx	Muscle Skeletal	SF3B2	0.14	0.09	lasso	6	0.09	9.5e-09	-5.6	5.9	2.9e-09	-0.15	0.04	0.96	TRUE
23	GTEx	Esophagus Gastroesophageal Junction	KCNK7	0.28	0.01	enet	42	0.15	5.9e-06	0.2	-5.5	3.8e-08	0.05	0.03	0.46	TRUE
36	GTEx	Nerve Tibial	TPCN2	0.28	0.13	enet	25	0.17	4.9e-12	-4.1	-5.3	1.2e-07	0.15	0.99	0.01	TRUE
39	GTEx	Nerve Tibial	CTD-3074O7.5	0.14	0.11	lasso	3	0.11	4.9e-08	5.2	-5.3	1.3e-07	0.15	0.61	0.36	TRUE
32	GTEx	Lung	CTD-3074O7.5	0.08	0.02	lasso	6	0.01	3.7e-02	5.2	-5.2	2.6e-07	0.23	0.18	0.15	TRUE
8	GTEx	Artery Tibial	RAD9A	0.39	0.26	lasso	2	0.24	3.5e-19	-12.4	-12.4	2.7e-35	1.00	0.00	1.00	FALSE
47	GTEx	Testis	RAD9A	0.72	0.50	lasso	4	0.49	1.1e-24	-12.4	-12.3	7.4e-35	1.00	0.00	1.00	FALSE
37	GTEx	Nerve Tibial	RAD9A	0.53	0.24	lasso	10	0.23	5.6e-16	-12.4	-12.1	1.7e-33	0.99	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	RAD9A	0.43	0.22	lasso	6	0.23	7.1e-19	-12.4	-11.8	2.3e-32	0.97	0.00	1.00	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	RAD9A	0.34	0.17	enet	21	0.20	1.1e-25	-12.4	-11.3	1.3e-29	0.89	0.00	1.00	FALSE
18	GTEx	Cells Transformed fibroblasts	RAD9A	0.24	0.16	lasso	3	0.16	3.6e-12	-12.4	-11.1	1.4e-28	0.92	0.00	1.00	FALSE
21	GTEx	Colon Transverse	RAD9A	0.40	0.16	lasso	8	0.16	7.2e-08	-12.4	-10.5	7.4e-26	0.88	0.00	1.00	FALSE
34	GTEx	Muscle Skeletal	RAD9A	0.12	0.02	lasso	4	0.03	4.2e-04	-12.4	-9.3	1.2e-20	0.83	0.00	0.99	FALSE
50	GTEx	Thyroid	RAD9A	0.27	0.07	lasso	6	0.20	1.8e-15	-12.4	-8.9	5.0e-19	0.70	0.00	1.00	FALSE
65	YFS	Blood	RAD9A	0.08	0.02	lasso	7	0.04	5.4e-12	-12.4	-8.7	3.4e-18	0.78	0.00	1.00	FALSE
63	YFS	Blood	CATSPER1	0.02	0.01	blup	352	0.01	5.5e-04	-5.5	6.7	3.0e-11	-0.21	0.01	0.98	FALSE
41	GTEx	Pancreas	DPP3	0.19	0.13	lasso	8	0.14	1.4e-06	5.3	-6.2	4.8e-10	0.15	0.42	0.57	FALSE
25	GTEx	Esophagus Muscularis	TCIRG1	0.10	0.09	lasso	2	0.06	8.7e-05	-4.8	6.2	6.8e-10	-0.43	0.20	0.08	FALSE
52	GTEx	Whole Blood	SF3B2	0.09	0.07	lasso	11	0.05	1.7e-05	-5.5	6.2	7.9e-10	-0.14	0.08	0.91	FALSE
13	GTEx	Breast Mammary Tissue	DPP3	0.14	0.07	lasso	2	0.05	1.5e-03	5.3	-6.0	1.4e-09	0.11	0.07	0.88	FALSE
10	GTEx	Artery Tibial	CTD-3074O7.12	0.08	0.01	enet	15	0.03	2.6e-03	-3.7	-6.0	2.0e-09	0.23	0.29	0.59	FALSE
35	GTEx	Nerve Tibial	SF3B2	0.13	0.12	lasso	3	0.10	2.3e-07	-5.5	5.9	3.6e-09	-0.15	0.02	0.98	FALSE
55	METSIM	Adipose	MTL5	0.07	0.04	bslmm	420	0.04	2.7e-06	3.7	5.8	5.4e-09	0.01	0.99	0.00	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	CCS	0.08	0.04	lasso	9	0.06	8.9e-08	5.6	-5.8	5.9e-09	0.20	0.23	0.77	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSF	0.05	0.04	blup	35	0.04	1.2e-05	5.5	5.8	6.7e-09	-0.16	0.02	0.97	FALSE
26	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	3.8	5.8	7.5e-09	0.05	0.61	0.30	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SF3B2	0.03	0.03	lasso	2	0.03	1.5e-04	-5.6	5.8	8.2e-09	-0.14	0.09	0.90	FALSE
56	NTR	Blood	CCS	0.03	0.04	lasso	2	0.04	1.2e-11	5.5	-5.8	8.6e-09	0.23	0.10	0.90	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ZDHHC24	0.22	0.11	enet	15	0.16	8.2e-05	5.5	-5.7	1.1e-08	0.08	0.10	0.52	FALSE
67	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	DPP3	0.05	0.02	blup	41	0.02	2.8e-02	5.2	-5.7	1.1e-08	0.15	0.02	0.68	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	BBS1	0.14	0.09	blup	48	0.10	3.0e-11	-3.7	-5.7	1.4e-08	0.22	0.98	0.02	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	PELI3	0.04	0.04	enet	4	0.03	9.0e-04	5.5	-5.7	1.4e-08	0.12	0.01	0.90	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	SF3B2	0.46	0.44	lasso	3	0.44	7.1e-62	-5.5	5.6	1.7e-08	-0.15	0.22	0.78	FALSE
30	GTEx	Lung	SF3B2	0.19	0.18	lasso	1	0.18	2.1e-13	-5.6	5.6	1.8e-08	-0.14	0.12	0.88	FALSE
48	GTEx	Testis	CTD-3074O7.5	0.22	0.16	enet	16	0.19	8.0e-09	5.5	5.6	1.9e-08	-0.18	0.43	0.56	FALSE
4	GTEx	Adipose Subcutaneous	DPP3	0.08	0.06	lasso	9	0.06	2.1e-05	5.2	-5.6	2.0e-08	0.14	0.42	0.58	FALSE
9	GTEx	Artery Tibial	DPP3	0.07	0.04	lasso	3	0.03	3.2e-03	5.5	-5.6	2.3e-08	0.13	0.30	0.63	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZDHHC24	0.03	0.03	blup	47	0.03	1.5e-04	5.5	5.6	2.6e-08	-0.20	0.06	0.91	FALSE
64	YFS	Blood	MTL5	0.05	0.03	blup	422	0.03	2.1e-11	-3.4	5.5	2.8e-08	-0.04	1.00	0.00	FALSE
51	GTEx	Vagina	CTD-3074O7.5	0.17	0.16	lasso	5	0.11	1.7e-03	5.5	-5.5	2.9e-08	0.14	0.13	0.40	FALSE
22	GTEx	Colon Transverse	CTD-3074O7.5	0.12	0.05	lasso	7	0.06	8.9e-04	5.2	-5.5	3.0e-08	0.20	0.16	0.41	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	DPP3	0.08	0.09	lasso	1	0.08	2.3e-05	5.5	-5.5	3.0e-08	0.13	0.35	0.53	FALSE
49	GTEx	Thyroid	SF3B2	0.18	0.15	lasso	2	0.14	5.8e-11	-5.5	5.5	3.0e-08	-0.14	0.08	0.92	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	ZDHHC24	0.03	0.04	lasso	1	0.04	6.4e-06	5.5	5.5	3.0e-08	-0.13	0.06	0.94	FALSE
6	GTEx	Artery Aorta	SF3B2	0.19	0.16	lasso	5	0.17	1.7e-09	-5.5	5.5	3.1e-08	-0.14	0.04	0.96	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	CCS	0.21	0.24	enet	11	0.21	2.0e-07	5.5	-5.5	3.2e-08	0.22	0.25	0.74	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPP3	0.03	0.03	blup	41	0.02	9.5e-03	5.5	-5.5	3.7e-08	0.10	0.04	0.73	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	BANF1	0.03	0.00	blup	44	0.02	3.9e-03	-2.6	5.5	3.8e-08	-0.13	0.02	0.48	FALSE
7	GTEx	Artery Aorta	ZDHHC24	0.09	0.09	lasso	2	0.06	2.0e-04	5.5	5.5	3.9e-08	-0.14	0.41	0.41	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DPP3	0.05	0.07	lasso	5	0.06	1.4e-04	5.5	-5.5	4.0e-08	0.13	0.04	0.83	FALSE
53	GTEx	Whole Blood	CTD-3074O7.5	0.07	0.05	lasso	4	0.04	1.3e-04	5.2	-5.4	5.4e-08	0.17	0.32	0.26	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPP3	0.05	0.06	lasso	4	0.07	6.2e-08	5.2	-5.4	5.7e-08	0.15	0.05	0.95	FALSE
40	GTEx	Nerve Tibial	CTD-3074O7.12	0.14	0.10	lasso	8	0.11	5.6e-08	5.5	-5.4	5.8e-08	0.17	0.36	0.64	FALSE
16	GTEx	Breast Mammary Tissue (Male)	CTD-3074O7.12	0.16	0.12	lasso	2	0.07	1.3e-02	5.5	-5.4	6.8e-08	0.13	0.10	0.24	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAPS3	0.04	0.02	blup	84	0.04	2.5e-05	-3.8	5.4	6.8e-08	0.00	0.21	0.78	FALSE
14	GTEx	Breast Mammary Tissue	CTD-3074O7.12	0.13	0.05	enet	9	0.05	1.4e-03	5.5	-5.4	7.5e-08	0.18	0.16	0.50	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	DPP3	0.07	0.09	blup	40	0.10	2.4e-10	5.5	-5.4	8.4e-08	0.15	0.05	0.95	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	CTSF	0.07	0.08	blup	244	0.07	1.6e-09	5.5	5.4	8.5e-08	-0.15	0.36	0.64	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPP3	0.48	0.14	lasso	8	0.15	1.6e-15	5.2	-5.3	8.7e-08	0.16	0.07	0.93	FALSE
5	GTEx	Adrenal Gland	RAD9A	0.46	0.08	lasso	3	0.22	2.9e-08	1.2	-5.3	9.3e-08	0.53	0.11	0.87	FALSE
24	GTEx	Esophagus Muscularis	SF3B2	0.17	0.10	lasso	7	0.11	4.3e-07	-5.5	5.3	1.1e-07	-0.07	0.02	0.98	FALSE
62	YFS	Blood	BBS1	0.02	0.02	lasso	5	0.02	1.4e-07	-3.8	-5.3	1.1e-07	0.22	0.65	0.35	FALSE
29	GTEx	Esophagus Muscularis	DPP3	0.06	0.08	lasso	5	0.07	7.7e-05	5.2	-5.3	1.2e-07	0.10	0.38	0.43	FALSE
46	GTEx	Spleen	CTD-3074O7.5	0.29	0.03	enet	27	0.05	2.6e-02	5.5	-5.3	1.2e-07	0.08	0.05	0.11	FALSE
44	GTEx	Small Intestine Terminal Ileum	CTSF	0.23	0.10	lasso	1	0.04	5.1e-02	5.3	-5.3	1.3e-07	0.13	0.05	0.30	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS6KB2	0.03	0.03	lasso	4	0.02	8.9e-04	6.5	-5.3	1.4e-07	0.07	0.00	0.99	FALSE
15	GTEx	Breast Mammary Tissue (Male)	DPP3	0.14	-0.01	lasso	1	-0.01	7.5e-01	5.3	-5.3	1.5e-07	0.13	0.03	0.08	FALSE
38	GTEx	Nerve Tibial	DPP3	0.19	0.11	enet	12	0.12	9.5e-09	5.2	-5.2	1.5e-07	0.05	0.64	0.34	FALSE
19	GTEx	Cells Transformed fibroblasts	CTD-3074O7.12	0.19	0.00	enet	20	0.03	3.5e-03	-3.7	-5.2	1.6e-07	0.14	0.05	0.79	FALSE
12	GTEx	Brain Cerebellum	MRGPRF	0.17	0.19	lasso	4	0.14	5.1e-05	-5.0	-5.2	1.7e-07	0.05	0.08	0.60	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BBS1	0.14	0.15	lasso	6	0.17	2.7e-07	5.2	-5.2	1.7e-07	0.13	0.11	0.88	FALSE
81	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EIF1AD	0.14	0.05	blup	42	0.08	3.9e-03	-4.6	-5.2	1.9e-07	0.13	0.01	0.51	FALSE
43	GTEx	Skin Sun Exposed Lower leg	DPP3	0.08	0.08	lasso	2	0.07	3.4e-06	5.2	-5.2	2.0e-07	0.13	0.47	0.50	FALSE
45	GTEx	Small Intestine Terminal Ileum	DPP3	0.15	0.02	lasso	3	0.01	1.5e-01	5.3	-5.2	2.1e-07	0.12	0.06	0.30	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	GAL	0.21	0.17	bslmm	393	0.17	1.5e-21	-5.3	-5.2	2.1e-07	-0.02	0.60	0.40	FALSE
31	GTEx	Lung	DPP3	0.09	0.08	enet	9	0.07	3.8e-06	5.3	-5.2	2.2e-07	0.13	0.58	0.42	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BBS1	0.12	0.10	lasso	6	0.11	5.1e-13	5.5	-5.2	2.4e-07	0.18	0.47	0.53	FALSE
20	GTEx	Colon Sigmoid	CTD-3074O7.12	0.11	0.01	lasso	4	0.02	4.5e-02	-4.4	-5.1	3.1e-07	0.27	0.09	0.40	FALSE