Hub : Genes

CCDC157

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0390 0.0150 9.1e-04 0.051 0.028 0.038 0.027 0.042 7.5e-07 2.2e-04 1.8e-05 0.00024 6.3e-06
2 GTEx Brain Frontal Cortex BA9 0.2373 0.0899 2.3e-03 0.001 NA 0.050 NA 0.011 2.9e-01 NA 1.9e-02 NA 1.6e-01
3 GTEx Heart Atrial Appendage 0.3770 0.0660 5.5e-11 0.290 NA 0.292 NA 0.314 1.7e-13 NA 1.3e-13 NA 1.2e-14
4 GTEx Heart Left Ventricle 0.1018 0.0387 2.9e-03 0.017 NA 0.008 NA 0.032 4.2e-02 NA 1.1e-01 NA 7.9e-03
5 GTEx Pancreas 0.1430 0.0530 2.4e-03 0.058 NA 0.006 NA 0.067 1.9e-03 NA 1.8e-01 NA 8.7e-04
6 GTEx Skin Sun Exposed Lower leg 0.1470 0.0550 3.2e-04 0.064 NA 0.030 NA 0.037 5.5e-06 NA 1.4e-03 NA 5.0e-04
7 GTEx Spleen 0.2470 0.0850 2.0e-03 0.010 NA 0.003 NA 0.023 1.7e-01 NA 2.7e-01 NA 8.6e-02
8 GTEx Stomach 0.2130 0.0740 3.4e-04 0.020 NA 0.028 NA 0.034 3.5e-02 NA 1.7e-02 NA 9.2e-03
9 GTEx Testis 0.4700 0.0740 2.2e-13 0.222 NA 0.258 NA 0.293 3.2e-10 NA 7.7e-12 NA 1.8e-13
10 TCGA Breast Invasive Carcinoma 0.0268 0.0121 1.5e-06 0.006 0.024 0.021 NA 0.016 1.8e-02 9.1e-06 3.2e-05 NA 2.7e-04
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0387 0.0223 7.8e-04 0.025 0.027 0.021 NA 0.030 7.5e-04 4.1e-04 1.8e-03 NA 2.1e-04
12 TCGA Brain Lower Grade Glioma 0.1139 0.0457 3.5e-12 0.094 0.094 0.092 NA 0.101 8.5e-11 8.1e-11 1.2e-10 NA 1.5e-11
13 TCGA Lung Adenocarcinoma 0.0311 0.0157 2.8e-04 0.024 0.030 0.022 NA 0.025 6.8e-04 1.6e-04 1.2e-03 NA 6.2e-04
14 TCGA Pancreatic Adenocarcinoma 0.0860 0.0500 7.9e-03 0.014 0.057 0.042 NA 0.026 7.9e-02 2.1e-03 7.6e-03 NA 2.9e-02
15 TCGA Stomach Adenocarcinoma 0.0530 0.0310 6.5e-03 0.005 0.027 0.013 NA 0.001 1.2e-01 4.7e-03 3.9e-02 NA 2.8e-01
16 TCGA Thyroid Carcinoma 0.0410 0.0200 6.1e-05 0.035 0.042 0.037 NA 0.034 2.4e-04 5.8e-05 1.4e-04 NA 2.8e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.7 1.2 4.6 -1.1 1.3 -1.0 -0.9 1.5 1.3 2.1 1.8 0.3 -0.1 -1.1 -0.6 -0.3 -0.6 0.6 -0.1
Bipolar Disorder or Schizophrenia 3.5 8.5 14.6 -3.1 2.6 -3.5 -3.7 3.2 3.7 3.8 2.8 -1.6 -2.0 -3.1 -3.0 -2.3 -3.0 1.0 -2.4
Depressed Affect (Nagel 2018) 0.6 1.2 6.1 0.8 2.0 0.9 0.8 -1.6 -0.7 0.2 0.5 -0.5 0.2 2.5 -0.1 1.2 0.1 -1.1 0.8
Depression (Nagel 2018) 0.2 0.3 1.8 0.2 1.3 -0.2 -0.0 -0.2 0.6 0.8 0.9 0.1 0.5 0.5 0.1 0.7 0.2 0.5 0.3
Intelligence (Savage-Jansen 2018) 0.5 1.5 3.9 1.1 -0.7 1.3 1.2 -0.8 -1.3 -0.1 -1.1 1.3 1.6 1.0 1.5 1.6 2.0 -0.1 1.7
Neuroticism (Nagel 2018) 0.2 0.4 2.0 0.8 0.6 0.5 0.6 -1.1 -0.1 0.2 0.6 0.2 0.4 1.4 0.2 1.1 -0.2 0.1 0.6
Schizophrenia (2018) 4.3 8.9 16.4 -3.1 2.4 -3.7 -4.1 2.9 3.7 3.2 2.2 -2.3 -2.5 -3.2 -3.4 -2.8 -3.3 0.8 -3.0
Schizophrenia vs Biploar Disorder 0.5 0.6 1.7 -0.3 0.5 -0.9 -1.0 -0.1 0.8 0.0 0.5 -1.3 -0.8 -0.2 -1.0 -0.8 -1.1 -0.0 -1.2
Worry (Nagel 2018) 0.2 0.3 2.6 0.1 0.8 -0.2 0.0 -0.3 0.4 0.7 1.6 0.3 -0.1 0.2 -0.2 0.5 -0.8 0.4 0.1
Alzheimer’s Disease (in mother) 0.6 0.7 2.3 0.9 -0.0 0.9 0.5 -1.5 -1.0 -1.1 -1.1 0.7 0.2 1.0 0.5 0.7 0.0 0.3 0.6
Alzheimer’s Disease (in father) 0.5 0.5 4.2 -0.1 -0.9 0.3 0.1 -0.8 0.1 -0.8 0.5 -0.4 -0.9 0.1 -0.4 -0.6 0.3 -2.0 -0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 2.3 0.8 -0.7 0.9 0.4 -1.5 -0.6 -1.4 -0.9 0.4 0.2 1.1 0.4 0.6 0.4 -0.3 0.5
Crohns Disease (2017) 0.1 0.2 1.2 -0.1 0.3 -0.2 -0.1 0.3 -0.1 -0.2 -0.6 0.5 0.2 -0.8 0.6 -0.1 0.1 1.1 0.1
Irritable Bowel Disease (IBD) 0.1 0.3 1.5 -0.5 -0.7 -0.7 -0.7 0.3 0.5 -0.2 -0.3 0.2 -0.3 -1.2 -0.2 -0.6 -0.5 0.9 -0.5
Ulcerative Colitis (UC) 0.3 0.7 1.6 -0.6 -0.9 -1.1 -1.2 0.2 0.9 0.3 0.2 -0.2 -0.8 -1.1 -0.9 -0.7 -1.2 0.6 -0.9
Major Depression (MDD) 0.4 0.5 1.7 0.6 1.3 0.1 -0.1 -0.1 0.1 0.1 0.5 0.5 1.0 0.0 0.6 0.7 0.7 1.3 0.8
Reaction Time 0.1 0.2 0.7 -0.4 -0.0 -0.4 -0.8 -0.1 0.4 0.5 0.8 -0.1 -0.4 -0.6 -0.6 -0.2 -0.8 0.3 -0.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 3.1 0.7 -0.2 0.9 0.9 -0.3 -1.1 0.3 -1.2 1.2 1.5 0.7 1.2 1.4 1.8 0.3 1.5
Breast Cancer 0.5 1.1 4.2 1.0 0.4 1.2 0.5 -2.0 -1.1 -1.6 -1.4 0.2 0.5 1.6 0.4 0.9 0.4 -0.5 0.7
Ovarian Cancer 0.2 0.3 2.8 0.2 -1.7 -0.1 0.3 -0.0 -0.0 0.1 -0.2 0.6 0.5 -0.5 0.6 0.1 0.2 1.0 0.2
Prostate Cancer 1.6 2.2 6.8 -1.6 -0.2 -1.7 -1.3 2.4 1.4 1.1 1.4 -0.2 -1.1 -2.6 -0.9 -1.7 -1.3 0.9 -1.7
Age at First Birth 0.6 0.9 4.9 -1.2 -0.2 -0.7 -0.7 1.2 0.5 0.6 0.0 0.4 -1.1 -2.2 -0.4 -1.1 -0.9 -0.1 -0.9
Bipolar Disorder (2011) 0.4 0.4 1.9 0.4 -0.6 0.6 -0.2 -0.6 -0.6 -0.3 -0.2 0.7 0.9 -0.0 0.1 0.2 1.4 -0.2 0.8
Body Mass Index (BMI) (2010) 0.1 0.2 0.7 0.0 0.5 0.3 0.1 -0.5 -0.4 -0.8 -0.2 -0.3 -0.0 0.4 -0.1 -0.2 0.5 -0.8 0.1
Coronary Artery Disease (CAD) 4.3 5.2 8.5 2.5 0.5 2.8 2.6 -2.9 -2.4 -1.5 -1.1 1.8 2.4 2.9 2.2 2.6 2.6 -0.1 2.9
Crohns Disease (2012) 0.4 0.7 3.4 -1.0 1.8 -0.7 -0.9 0.8 0.5 0.1 0.6 -0.8 -0.3 -1.0 -0.4 -1.0 0.0 0.1 -0.6
Mean Putamen Volume 0.7 0.8 5.0 -0.2 -2.2 -0.0 -0.3 -0.6 -0.1 -1.1 -1.3 -0.7 -1.0 0.1 -0.5 -0.7 -0.8 -0.8 -0.8
Fasting Glucose 0.3 0.4 2.5 -0.0 -0.6 -0.2 -0.2 0.3 0.3 -0.4 -0.2 -0.4 -0.9 -0.8 -0.0 -1.0 0.2 -1.6 -0.8
HbA1C 0.4 0.4 2.0 -0.0 -0.8 -0.8 -0.7 0.2 0.3 0.4 0.1 -1.4 -0.7 0.3 -0.3 -0.6 -0.7 -0.5 -0.9
HDL Cholesterol 0.8 1.3 2.8 -1.3 -0.3 -1.2 -1.0 1.2 0.8 0.8 0.9 -1.0 -1.6 -1.6 -1.2 -1.7 -0.7 -1.2 -1.3
LDL Cholesterol 0.8 1.2 5.6 -0.4 -0.1 -0.9 -0.9 1.6 0.9 1.7 1.4 1.0 0.7 -1.2 0.0 0.5 -0.4 2.4 0.6
Lupus 0.2 0.3 0.8 -0.4 0.8 -0.4 -0.3 0.4 0.7 -0.1 0.9 -0.6 -0.2 -0.3 -0.6 -0.6 0.1 -0.6 -0.5
Neuroticism (2016) 0.1 0.1 0.8 0.4 0.9 0.1 -0.1 -0.3 0.0 -0.2 0.7 -0.1 0.3 0.2 -0.1 0.3 0.2 0.1 0.2
Primary Biliary Cirrhosis 4.2 6.0 12.2 2.5 -0.4 2.9 3.0 -2.5 -2.7 -1.8 -2.0 2.1 2.5 2.5 2.7 2.4 3.5 -0.7 2.8
Rheumatoid Arthritis 0.6 0.9 3.9 0.3 0.2 0.7 1.3 -1.0 -0.7 -2.0 -0.6 -0.6 -0.8 0.7 0.2 -0.7 0.2 -1.8 -0.5
Schizophrenia (2014) 2.2 5.0 8.8 -2.0 2.6 -2.7 -2.8 1.8 3.0 2.8 1.8 -1.4 -1.6 -2.0 -2.5 -1.5 -2.8 0.9 -2.0
Triglycerides 0.3 0.5 1.8 -0.7 0.3 -1.1 -0.8 1.0 1.0 0.8 0.8 -0.4 0.3 -0.7 -0.3 -0.1 -0.4 1.3 -0.1
Type 2 Diabetes (T2D) (2012) 1.0 1.1 4.6 -1.4 0.5 -0.8 -0.7 0.9 1.0 -0.0 0.4 -1.9 -1.2 -0.1 -1.1 -1.2 -0.0 -2.1 -1.0
Ulcerative Colitis 1.1 1.6 3.9 -1.2 -0.8 -1.3 -0.9 0.8 1.1 -0.0 0.7 -1.0 -1.7 -1.7 -1.2 -2.0 -1.2 -0.9 -1.9
Blood Eosinophil Count 1.8 13.8 25.0 -3.9 2.3 -3.6 -3.5 2.8 3.3 1.6 3.0 -4.4 -4.8 -3.0 -4.6 -4.8 -4.4 -2.0 -5.0
Blood Platelet Count 6.2 72.1 102.0 -9.9 2.6 -10.1 -8.7 9.0 10.1 6.4 8.6 -8.6 -8.7 -8.8 -8.9 -10.0 -8.0 -3.0 -9.7
Blood Red Count 0.4 3.5 26.1 1.2 3.0 -0.4 -0.0 1.1 0.2 1.7 0.2 0.7 2.2 0.8 1.0 2.2 -0.6 5.1 1.6
Blood White Count 0.1 1.1 3.0 -1.2 0.7 -1.6 -1.3 1.7 1.4 1.2 -0.2 -1.0 -0.2 -0.8 -0.7 -0.5 -0.7 1.1 -0.7
Heel T-Score 3.9 30.9 49.8 -5.8 4.5 -6.2 -5.2 7.1 5.3 6.4 6.8 -4.2 -5.7 -5.1 -5.2 -5.5 -6.4 0.1 -6.0
BMI 0.3 2.0 7.9 -1.1 1.9 -0.8 -1.2 -0.1 0.8 -0.5 -0.2 -2.8 -1.6 0.4 -1.9 -1.7 -0.9 -1.9 -1.7
Height 0.0 0.8 3.0 0.4 1.2 1.0 0.1 -1.0 -1.1 0.6 -0.5 1.7 0.5 0.2 0.3 0.7 1.2 -0.4 1.3
Waist Hip Ratio (WHR) 7.0 31.7 44.0 6.2 -3.6 6.6 6.2 -5.5 -6.3 -5.6 -5.7 6.6 5.6 3.6 6.6 5.5 6.4 0.8 6.0
Systolic Blood Pressure 0.2 1.2 5.8 -0.1 -1.7 0.6 0.5 -0.6 -0.4 -1.7 0.1 -0.1 -1.5 -1.2 -0.0 -1.4 0.5 -2.4 -0.8
Smoking Status 0.8 1.9 3.8 -1.7 1.9 -1.3 -0.4 1.3 1.1 0.2 1.3 -2.0 -1.4 -0.8 -1.2 -1.8 -0.2 -1.9 -1.5
Allergy or Eczema 0.7 1.9 4.9 -1.1 1.0 -1.4 -1.7 1.5 1.5 1.3 1.5 -0.6 -1.3 -2.2 -1.2 -1.6 -1.3 0.1 -1.5
Cardiovascular Disease 0.7 2.3 6.1 1.2 0.2 2.0 1.6 -2.5 -1.9 -2.3 -0.6 0.5 0.6 1.8 0.8 0.9 1.8 -2.0 1.1
Hypothyroidism (self reported) 1.3 3.0 6.3 1.8 -0.4 2.5 2.1 -2.3 -2.4 -2.4 -0.7 0.9 0.7 1.9 1.4 0.9 1.8 -1.9 1.1
Respiratory disease 0.8 1.9 5.4 -1.3 0.0 -1.6 -1.7 1.2 1.6 0.8 1.4 -0.9 -1.3 -1.6 -1.4 -1.2 -2.3 0.8 -1.3
Type 2 Diabetes (T2D) (2018) 0.7 1.3 4.8 -0.3 -0.2 0.0 -0.5 -1.2 -0.1 -1.6 -0.4 -2.2 -1.2 0.9 -1.3 -0.9 -0.4 -2.2 -1.0
Lung FEV1/FVC ratio 0.7 3.6 13.6 1.1 2.8 0.3 1.1 0.8 -0.4 2.7 0.9 3.7 1.9 -0.8 1.7 1.8 0.5 3.4 1.8
Lung FVC 2.5 12.5 18.2 -4.2 2.2 -4.2 -3.3 4.0 4.0 2.2 3.6 -3.5 -3.6 -3.7 -3.7 -4.3 -2.8 -1.8 -4.1
Neuroticism 0.2 0.5 4.1 0.3 2.0 0.3 0.1 -1.0 -0.1 0.4 0.8 -0.3 -0.3 1.0 -0.4 0.5 -0.5 -0.6 0.1
Chronotype (morning person) 0.4 1.0 4.1 0.2 1.0 -0.4 -0.5 0.7 0.7 1.7 0.8 0.9 0.6 0.2 0.1 1.4 -1.3 2.0 0.6
Hair Pigment 0.0 0.9 3.7 -1.0 0.7 -0.8 -0.2 1.0 0.6 0.5 1.4 0.2 -1.3 -1.9 -0.4 -1.5 -0.7 -0.2 -1.0
Tanning 0.4 5.4 9.7 -2.3 -0.3 -2.5 -2.8 2.4 2.6 1.7 2.2 -3.0 -2.6 -1.1 -3.1 -2.3 -2.7 -0.9 -2.7
Hand grip strength (left) 0.1 0.3 0.8 -0.3 0.9 -0.4 -0.7 0.2 0.2 -0.2 -0.2 -0.6 -0.6 -0.2 -0.7 -0.7 -0.8 0.4 -0.7
Number of treatments/medications taken 0.5 0.9 3.5 0.9 0.1 1.1 0.8 -1.9 -0.6 -1.1 0.1 0.5 0.6 1.7 0.5 1.4 0.5 -0.5 1.1
Average weekly spirits intake 0.3 0.4 1.4 -0.8 -0.9 -0.7 -0.8 1.2 0.4 0.4 0.4 -0.8 -0.3 -0.7 -0.6 -0.8 0.1 -0.3 -0.5
Sensitivity / hurt feelings 0.5 0.8 2.4 1.1 0.1 0.7 0.7 -0.7 -0.6 -1.0 -0.5 1.0 1.5 0.4 0.9 0.9 0.9 1.6 0.8
Frequency of depressed mood in last 2 weeks 0.4 0.6 4.3 0.3 2.1 -0.2 -0.0 -0.2 0.4 0.6 1.0 0.2 0.9 0.6 0.2 0.9 0.3 0.9 0.6
Hearing difficulty/problems: Yes 0.9 1.4 3.5 -1.1 0.2 -1.4 -1.3 1.5 1.2 1.5 0.2 -0.1 -1.2 -1.7 -0.9 -0.8 -1.9 1.3 -1.1
Relative age of first facial hair 0.7 1.5 5.8 0.9 -0.5 1.6 2.0 -1.1 -1.6 -2.4 -0.8 0.5 0.2 1.0 1.0 0.0 1.1 -1.6 0.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 4.6 -0.1 0.2 0.5 0.2 -1.3 -0.3 -0.8 -0.5 -0.6 -0.6 0.9 -0.3 0.2 0.2 -2.1 0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.7 6.8 -0.4 -0.6 0.4 0.6 -0.7 -0.4 -1.0 0.2 -0.2 -0.6 0.2 -0.1 -0.5 0.8 -2.6 -0.0
Ever had hysterectomy (womb removed) 0.1 0.2 0.8 0.1 -0.9 0.2 0.4 -0.6 -0.0 -0.8 0.2 -0.2 -0.1 0.3 0.1 0.0 0.4 -0.5 0.2
Systolic blood pressure, automated reading 1.0 2.9 10.4 -1.6 -1.1 -0.8 -0.8 0.3 1.0 -0.6 1.0 -1.7 -2.8 -1.7 -1.6 -2.7 -0.9 -3.2 -2.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.5 -0.8 -0.4 -0.4 -0.8 0.1 0.6 -0.2 1.0 -1.9 -1.3 0.5 -1.3 -0.7 -0.6 -1.8 -0.9
Angina 2.9 3.8 11.4 2.0 0.2 2.3 1.7 -3.0 -2.0 -1.7 -1.7 0.6 1.8 3.4 1.2 2.4 1.5 -0.3 2.2
Medication for hormone replacement therapy 1.0 1.1 6.0 -0.5 -0.7 -1.1 -0.8 1.0 0.8 1.3 0.5 0.6 -0.2 -1.5 -0.1 -0.2 -1.5 2.5 -0.4
Vitamin and mineral supplements 0.3 0.4 1.1 0.8 0.1 0.4 0.5 -0.6 -0.3 0.6 -0.2 0.5 0.9 0.8 0.6 1.0 0.7 0.5 0.8
Supplements: Zinc 0.3 0.3 2.0 -0.2 -0.2 -0.8 -0.1 0.6 0.8 0.5 0.6 -0.1 0.4 -0.6 0.1 -0.0 -0.6 1.4 -0.1
Medication: Co-codamol 0.7 0.8 4.7 0.2 0.8 0.8 0.4 -1.5 -0.8 -1.1 -0.1 -0.9 -0.1 1.4 -0.4 0.1 0.6 -2.2 0.1
Medication: Metformin 1.0 1.5 7.9 -0.3 -0.3 0.2 -0.5 -1.4 0.3 -1.9 0.3 -2.1 -1.1 0.9 -1.3 -0.8 0.0 -2.8 -0.8
Diabetes (father) 0.6 0.8 1.7 -0.8 1.0 -1.0 -0.8 0.7 0.9 1.1 0.9 -0.4 -0.9 -1.3 -0.6 -0.6 -1.2 0.3 -0.8
Diabetes (mother) 1.2 1.5 3.9 -1.0 0.1 -0.5 -1.3 -0.2 0.7 -0.8 1.1 -1.9 -1.6 -0.9 -1.7 -1.7 -0.3 -2.0 -1.3
Severe depression (siblings) 0.4 0.5 4.0 -0.9 0.3 -0.3 -0.1 -0.2 0.3 0.5 0.6 -0.8 -0.3 -0.2 -0.6 -0.8 0.4 -2.0 -0.4
Pack years adult smoking proportion 0.5 0.7 4.7 0.6 2.2 0.5 0.1 -1.3 -0.2 -0.8 -0.4 -0.2 0.8 1.2 0.1 0.8 0.6 0.0 0.8
Impedance of leg (right) 0.7 3.6 10.6 1.9 -1.3 1.9 2.0 -1.5 -1.8 0.3 -0.9 3.3 2.0 0.8 2.5 2.6 1.1 1.5 2.6
Leg fat-free mass (left) 0.1 0.8 2.5 0.6 1.5 0.7 0.3 -0.9 -0.8 -1.2 -1.6 -0.3 0.6 1.1 0.0 0.0 1.2 -0.3 0.4
Trunk fat percentage 0.9 3.7 8.4 1.6 0.1 2.4 2.0 -2.9 -2.3 -2.0 -1.9 0.4 1.1 2.6 1.2 1.2 2.6 -2.1 1.8
Hand grip strength (right) 1.2 3.3 5.2 -2.0 1.9 -2.1 -2.3 1.7 1.9 1.1 1.7 -1.8 -1.8 -1.6 -2.1 -1.9 -2.0 0.4 -1.8
Townsend deprivation index at recruitment 0.7 1.0 4.3 0.8 -0.2 0.9 0.8 -1.5 -0.7 -1.4 -0.6 -0.5 0.6 2.1 0.5 1.0 0.8 -1.0 0.6
Current tobacco smoking 0.6 1.0 12.5 -0.2 3.5 -0.3 0.1 -0.2 0.2 -0.1 0.3 -1.3 0.1 1.2 -0.3 0.0 0.2 -0.6 -0.1
Average weekly fortified wine intake 1.7 2.0 3.7 1.7 0.5 1.7 1.5 -1.1 -1.9 -0.5 -1.4 1.6 1.5 1.4 1.6 1.8 0.9 1.0 1.6
Maternal smoking around birth 1.1 1.6 3.5 -1.4 0.6 -1.4 -1.4 1.3 1.4 0.6 1.4 -1.9 -1.2 -0.5 -1.6 -1.4 -0.8 -1.0 -1.3
Fed-up feelings 0.8 1.5 5.0 1.2 1.5 0.7 1.0 -0.6 -0.5 1.0 0.4 0.8 1.5 1.8 1.0 2.2 0.4 1.4 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 2.5 -0.2 1.6 -0.4 -0.5 0.1 0.4 0.9 0.7 -0.5 0.3 0.5 -0.3 0.4 -0.1 0.1 0.0
Relative age voice broke 0.4 0.6 2.5 0.4 0.9 0.8 0.7 -1.0 -0.8 -1.6 -0.2 -0.1 0.0 0.6 0.0 -0.4 1.0 -1.5 -0.0
Taking other prescription medications 0.2 0.2 0.8 0.2 0.6 0.2 -0.0 -0.9 0.3 0.5 0.7 0.5 -0.2 0.4 -0.1 0.9 -0.6 -0.2 0.4
Age when periods started (menarche) 3.4 8.1 17.2 -3.1 0.2 -3.5 -2.5 4.1 3.0 2.1 2.3 -1.7 -2.9 -4.0 -2.2 -3.5 -3.0 0.2 -3.3
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.5 0.8 -0.4 0.8 0.9 -1.2 -0.7 -0.7 -0.5 0.5 0.7 1.2 0.7 1.0 0.7 -0.3 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 4.4 -1.3 1.5 -1.5 -1.4 1.9 1.1 1.8 0.7 -0.4 -1.5 -2.1 -1.1 -1.6 -2.0 1.2 -1.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.7 -0.1 0.4 -0.2 -0.2 -0.6 0.4 -0.1 0.8 -0.9 -0.4 0.2 -0.4 -0.0 -0.4 -0.5 -0.2
Qualifications: CSEs or equivalent 1.2 1.5 3.1 1.5 0.3 1.2 1.2 -1.5 -1.4 -0.8 -1.2 0.9 1.4 1.8 1.1 1.7 0.6 1.1 1.3
Serious illness, injury or assault to yourself 0.1 0.1 0.4 -0.1 0.6 0.1 -0.1 0.2 0.0 0.5 0.1 0.2 -0.2 0.5 -0.1 0.6 -0.1 -0.5 0.3
High blood pressure 1.1 3.1 8.6 1.2 -1.2 2.3 1.8 -2.7 -2.0 -2.9 -1.2 0.2 0.3 1.7 0.9 0.4 2.2 -2.7 1.0
Hayfever, allergic rhinitis or eczema 0.1 0.1 1.2 0.1 0.3 -0.1 -0.1 0.2 0.0 -0.1 0.4 0.2 -0.3 -1.1 0.1 -0.7 0.1 -0.3 -0.3
Multivitamins +/- minerals 0.2 0.3 1.5 0.3 -1.2 0.4 0.5 0.1 -0.3 -0.8 -0.2 1.0 0.4 -0.1 0.6 0.3 0.0 0.6 0.4
Stomach or abdominal pain in last month 0.4 0.6 3.8 -0.6 0.6 -0.2 -0.4 -0.3 0.5 -0.1 1.1 -1.1 -0.5 0.4 -0.7 -0.3 0.2 -2.0 -0.3
Supplements: Glucosamine 0.3 0.4 0.9 0.6 0.5 0.7 0.5 -0.4 -0.8 -0.7 0.3 0.4 0.9 0.8 0.5 0.7 1.0 0.3 0.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.5 0.3 -0.8 0.7 1.0 -0.2 -0.8 -0.1 -0.4 1.2 0.0 -0.6 0.7 0.1 0.5 -0.2 0.5
Medication: Atenolol 1.4 1.7 3.9 1.1 -1.3 1.6 2.0 -1.5 -1.4 -1.5 -1.0 0.8 0.6 1.8 1.3 1.3 0.8 -0.8 1.2
Medication: Levothyroxine sodium 1.4 2.4 6.3 2.0 -0.0 2.3 1.5 -2.5 -2.1 -1.8 -0.8 1.1 1.0 1.9 1.0 1.3 1.3 -0.7 1.3
Sitting height 0.2 1.6 3.6 -1.4 1.9 -1.5 -1.5 1.2 1.1 1.5 0.7 -1.2 -1.0 -0.8 -1.5 -1.4 -1.0 0.0 -1.3
Chronic bronchitis/emphysema (father) 0.3 0.3 1.4 0.2 -0.7 0.6 0.4 -0.7 -0.3 -1.2 0.1 -0.3 -0.5 0.4 -0.1 -0.1 -0.2 -1.1 -0.2
High blood pressure (mother) 1.8 2.6 6.9 1.8 -0.6 1.5 1.6 -1.3 -1.2 -0.5 -1.9 2.6 1.6 0.3 2.1 2.0 1.2 1.7 1.9
Body mass index (BMI) 0.2 0.9 2.4 0.2 1.2 0.4 0.3 -1.1 -0.3 -1.4 -1.0 -1.6 -0.2 1.4 -0.5 -0.4 0.7 -1.5 -0.3
Impedance of leg (left) 0.5 2.3 7.2 1.5 -1.1 1.6 1.7 -1.3 -1.5 -0.0 -0.7 2.7 1.5 0.4 2.0 1.9 0.8 1.0 2.0
Leg predicted mass (left) 0.1 0.8 2.4 0.7 1.5 0.7 0.4 -1.0 -0.8 -1.2 -1.5 -0.3 0.6 1.2 0.0 0.1 1.2 -0.3 0.4
Trunk fat mass 0.6 2.8 6.8 1.3 0.8 2.0 1.6 -2.6 -1.9 -2.0 -1.9 0.1 0.9 2.2 0.9 0.8 2.3 -1.9 1.4
Waist circumference 1.5 5.6 10.9 2.7 0.1 2.9 2.7 -3.3 -2.6 -3.2 -3.0 1.2 1.8 2.7 2.0 1.7 2.7 -0.8 2.1
Number of incorrect matches in round 0.3 0.4 1.0 -0.8 -0.1 -0.7 -0.8 0.5 0.7 0.3 0.0 -0.6 -0.6 -1.0 -0.7 -0.8 -0.6 -0.3 -0.8
Past tobacco smoking 3.1 5.7 11.2 2.9 0.0 2.3 1.2 -2.2 -2.5 -1.1 -2.7 2.3 2.9 2.6 2.3 3.2 1.2 3.3 2.8
Alcohol usually taken with meals 0.2 0.3 1.0 -0.3 0.6 -0.3 -0.7 0.5 0.0 0.9 -0.6 0.1 -0.3 -1.0 -0.5 -0.6 -0.7 0.5 -0.5
Nervous feelings 0.2 0.4 1.4 0.4 -0.4 0.4 0.7 -0.6 -0.5 0.4 0.4 0.7 0.7 0.9 0.6 1.2 -0.1 0.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 4.2 0.4 2.1 0.1 0.4 0.2 -0.1 -0.3 0.8 -0.4 1.4 1.3 0.4 0.7 0.8 0.8 0.6
Hearing difficulty/problems with background noise 0.5 0.8 1.6 -0.8 -1.1 -0.8 -0.9 0.1 0.9 1.0 0.4 -1.2 -1.1 0.2 -1.2 -0.4 -1.3 -1.0 -0.8
Hair/balding pattern: Pattern 2 0.2 0.3 1.2 0.3 0.0 0.5 0.6 -0.7 -0.4 -0.9 -0.7 0.1 0.5 0.3 0.4 0.1 1.1 -0.6 0.3
Had menopause 1.2 1.5 5.6 -1.3 0.6 -0.8 -0.9 0.1 0.9 0.3 1.3 -1.9 -1.4 -0.2 -1.6 -1.7 -0.2 -2.4 -1.1
Had other major operations 0.2 0.3 1.7 -0.4 0.6 -0.3 -0.6 0.8 0.5 -0.2 0.1 0.4 -0.7 -1.3 -0.2 -0.7 -0.2 -0.0 -0.4
Forced vital capacity (FVC) 0.3 1.3 2.9 -1.4 1.7 -1.4 -0.9 1.7 1.1 1.1 1.1 -0.5 -0.9 -1.4 -0.9 -1.3 -0.4 -0.1 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.4 -0.6 1.5 -0.6 -0.5 0.6 0.2 1.5 0.6 -0.1 -0.8 -0.7 -0.5 -0.7 -1.0 0.4 -0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.5 -0.5 1.0 -0.7 -0.8 0.3 0.5 0.1 0.3 -0.6 -0.7 -0.4 -0.6 -0.3 -1.2 0.6 -0.8
Qualifications: None of the above 0.2 0.5 3.6 0.4 0.4 0.2 -0.0 -0.6 0.5 0.4 0.5 -0.8 0.4 1.9 -0.3 1.0 -0.1 -0.5 0.4
Financial difficulties in last 2 years 0.4 0.6 6.6 -0.1 2.6 -0.1 -0.0 0.4 -0.1 0.2 1.4 -0.4 -0.4 0.3 -0.4 -0.2 -0.1 -0.5 -0.2
Mouth/teeth dental problems 0.5 0.7 2.4 -0.8 0.4 -0.8 -0.9 1.1 0.8 0.7 0.2 -0.1 -1.1 -1.5 -0.5 -1.1 -1.0 0.4 -1.0
Heart attack 2.7 3.4 5.4 2.1 0.4 2.1 2.0 -1.9 -1.9 -1.4 -1.5 1.7 2.2 2.1 1.8 2.3 1.9 0.9 2.3
Allergy 0.1 0.2 0.8 -0.2 -0.5 -0.1 0.0 0.3 0.1 0.8 0.1 0.0 0.6 0.9 -0.0 0.7 0.3 0.4 0.4
Pain all over the body in last month 0.1 0.1 0.5 0.0 -0.7 -0.1 0.2 -0.0 0.1 0.4 -0.2 -0.4 0.0 0.4 0.0 0.6 -0.3 0.0 0.1
Diabetes (self-reported) 1.4 2.1 9.2 -1.1 -0.1 -0.3 -0.9 -0.8 0.5 -1.2 0.7 -2.5 -1.9 0.3 -1.9 -1.6 -0.9 -3.0 -1.6
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 4.6 1.3 -2.1 1.1 0.9 -1.4 -1.4 -0.5 -1.2 0.7 1.2 1.4 1.0 1.3 0.6 0.9 1.3
Medication: Ramipril 0.3 0.3 1.1 -0.4 -0.6 -0.7 -0.5 0.7 0.9 0.9 0.4 -0.4 0.3 -0.8 -0.1 -0.0 0.1 1.0 0.1
Medication: Simvastatin 0.7 1.1 3.2 0.9 1.1 1.1 0.7 -1.8 -0.9 -1.6 -0.1 0.1 0.5 1.8 0.4 1.4 0.6 -0.6 0.9
Fluid intelligence score 0.4 0.9 2.0 0.6 0.2 0.4 0.6 -0.2 -0.5 0.5 -1.4 1.1 1.4 0.4 1.2 1.2 1.3 1.0 1.2
Illnesses of siblings 0.2 0.2 1.4 0.2 0.8 0.0 0.1 0.1 -0.6 0.3 -0.6 0.5 0.4 -0.0 0.3 -0.0 -0.3 1.2 0.0
Neuroticism score 0.3 0.6 3.4 0.3 1.8 -0.0 0.1 -0.2 0.1 1.1 1.2 0.0 0.4 1.0 -0.1 1.0 -0.5 0.6 0.4
Weight 0.3 1.4 3.3 0.8 1.5 1.1 0.8 -1.7 -1.1 -1.7 -1.8 -0.5 0.5 1.6 0.1 0.0 1.5 -1.2 0.5
Impedance of arm (right) 1.0 4.8 9.9 2.1 -2.1 2.4 2.1 -2.0 -2.4 0.3 -1.0 3.0 2.2 1.8 2.6 3.1 2.0 0.4 3.1
Arm fat percentage (right) 0.7 2.7 7.4 1.4 0.3 1.8 1.6 -2.5 -1.7 -1.5 -1.8 -0.0 1.2 2.7 0.9 1.3 2.1 -1.6 1.6
Trunk fat-free mass 0.1 0.5 4.1 0.5 2.0 0.2 0.0 -0.4 -0.2 -1.0 -1.2 -0.3 0.2 0.5 -0.3 -0.4 0.4 0.4 -0.1
Hip circumference 0.4 1.5 4.8 1.2 1.2 1.3 1.0 -2.0 -1.2 -1.3 -1.6 -0.4 0.8 2.2 0.3 0.7 1.4 -0.8 0.9
Time employed in main current job 2.5 2.9 5.0 -2.1 0.3 -1.5 -1.9 1.2 1.2 1.0 2.1 -2.0 -2.1 -1.6 -2.1 -2.2 -1.2 -1.8 -1.7
Alcohol intake versus 10 years previously 0.3 0.5 3.5 -0.2 0.2 0.4 0.1 -1.0 -0.3 -0.4 -0.1 -0.9 -0.7 0.8 -0.4 -0.2 -0.0 -1.9 -0.4
Father’s age at death 2.2 3.0 8.6 -2.0 0.5 -1.4 -1.7 1.0 0.9 1.2 0.3 -1.1 -2.9 -2.3 -1.6 -2.4 -1.7 -1.9 -2.1
Worrier / anxious feelings 0.2 0.4 2.0 0.2 0.8 0.3 0.2 0.1 0.1 0.1 1.4 0.9 0.7 -0.2 0.4 0.7 0.4 0.4 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.6 0.7 0.7 0.7 0.7 -0.8 -0.6 -0.7 -0.2 -0.2 0.8 1.2 0.5 0.7 1.0 -0.5 0.6
Falls in the last year 1.7 2.4 5.6 1.5 -0.1 1.7 1.7 -2.4 -1.9 -1.8 -2.0 0.4 1.0 2.1 1.3 1.4 1.4 -0.9 1.2
Hair/balding pattern: Pattern 3 0.9 1.4 3.7 1.0 0.0 1.4 1.2 -1.8 -1.2 -1.3 -1.4 0.2 0.6 1.9 0.7 1.1 0.9 -1.1 1.0
Number of live births 3.2 4.5 7.2 2.7 -1.2 2.4 2.6 -2.1 -2.3 -1.3 -1.1 2.5 2.6 2.2 2.3 2.5 1.8 1.0 2.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 5.9 -1.3 2.4 -1.8 -0.9 2.4 1.4 2.3 1.8 0.2 -0.3 -1.8 -0.6 -0.9 -0.5 1.3 -0.8
Pulse rate 0.2 0.3 1.7 0.1 -1.3 -0.4 -0.4 -0.2 0.4 -0.1 -0.2 -0.5 -0.2 0.4 -0.4 0.2 -0.9 0.7 -0.2
Happiness 1.0 1.2 5.9 1.1 2.4 0.9 1.1 -0.9 -0.7 -0.7 -0.3 0.4 1.2 1.5 1.0 1.3 1.1 0.0 1.0
Noisy workplace 0.9 1.1 2.9 0.8 -0.5 1.1 1.5 -1.6 -1.0 -1.5 -1.3 -0.4 0.0 1.7 0.6 0.5 0.5 -1.4 0.3
Qualifications: A levels/AS levels or equivalent 1.8 4.0 8.3 1.7 -2.4 2.5 2.4 -1.4 -2.4 -2.9 -2.3 2.3 1.1 0.6 2.1 0.8 2.5 -1.1 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 0.2 0.1 0.3 0.3 0.5 -0.1 0.4 0.6 0.8 0.5 -0.4 0.5 0.3 0.7 -0.2 0.4
Mouth/teeth dental problems: Dentures 0.3 0.5 3.4 -0.5 0.5 -0.0 -0.1 -0.5 0.1 -0.1 0.9 -1.1 -0.3 0.9 -0.7 -0.1 0.6 -1.9 -0.0
Asthma 0.2 0.3 1.8 0.1 -0.5 -0.3 0.0 -0.2 0.3 -0.8 -0.1 0.2 -0.4 -0.8 0.0 -0.4 -1.3 1.0 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.3 -0.4 0.5 -0.2 0.4 1.0 -0.1 0.8 1.1 -0.0 0.2 -0.0 0.5 0.1 0.5 -0.4 0.1
Medication: Cholesterol lowering 0.2 0.3 1.3 0.1 -0.6 0.4 0.2 -1.1 -0.1 -0.5 -0.5 -0.2 0.1 1.0 -0.0 0.9 -0.1 -0.7 0.6
Depression (self-reported) 1.6 1.9 4.0 1.6 0.4 1.5 1.2 -1.5 -1.7 -0.4 -0.6 1.2 1.6 1.9 1.3 2.0 1.1 1.0 1.8
Medication: Lansoprazole 3.1 3.6 7.9 1.9 2.8 2.1 1.9 -2.4 -1.8 -1.9 -0.3 0.8 1.9 2.6 1.4 1.8 2.2 -0.7 1.8
Prospective memory result 0.3 0.4 2.3 -0.3 0.4 -0.4 -0.3 0.2 0.6 0.7 1.0 -0.6 -1.0 0.3 -0.6 -0.0 -1.5 -0.2 -0.6
Lung cancer (father) 0.5 0.6 2.7 -0.7 0.1 -0.1 0.1 0.1 0.1 -0.1 0.7 -1.0 -1.3 -0.4 -0.6 -1.2 -0.3 -1.6 -1.0
Illnesses of mother 1.0 1.3 2.8 -1.2 1.7 -1.2 -1.1 1.1 0.9 1.2 1.5 -1.7 -0.5 0.1 -1.3 -0.9 -1.0 -0.2 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 6.7 -0.6 1.9 -1.4 -0.5 2.1 0.9 2.1 1.0 1.0 0.5 -1.6 0.1 -0.2 -0.4 2.6 -0.3
Pulse wave Arterial Stiffness index 0.2 0.3 1.0 0.4 0.8 0.6 0.4 -1.0 -0.2 -0.1 -1.0 0.3 -0.0 0.4 0.1 0.4 0.0 -0.7 0.3
Impedance of arm (left) 1.3 5.8 11.6 2.3 -2.2 2.6 2.4 -2.2 -2.6 -0.2 -1.3 3.4 2.5 1.6 3.0 3.2 2.5 0.6 3.3
Arm fat mass (right) 0.5 1.9 4.7 1.2 1.1 1.5 1.2 -2.1 -1.3 -1.6 -1.7 -0.2 1.0 2.2 0.6 0.8 1.9 -1.1 1.1
Trunk predicted mass 0.1 0.5 4.6 0.4 2.1 0.2 -0.0 -0.4 -0.2 -0.9 -1.2 -0.4 0.2 0.4 -0.3 -0.4 0.3 0.3 -0.2
Standing height 0.2 2.1 4.8 1.4 0.6 1.7 1.1 -1.5 -1.8 -0.9 -2.0 2.2 1.4 0.4 1.4 1.0 2.0 0.5 1.7
Length of working week for main job 0.5 0.6 3.2 0.4 -0.1 0.5 0.5 -0.3 -0.4 -1.8 -0.4 -0.2 0.4 -0.2 0.5 -0.6 1.7 -0.9 0.1
Exposure to tobacco smoke at home 0.7 0.8 7.2 -0.6 -0.4 -0.2 -0.2 -0.7 0.8 0.1 0.8 -1.5 -0.7 0.6 -0.7 -0.3 0.3 -2.7 -0.3
Breastfed as a baby 0.2 0.2 1.5 -0.1 -1.2 0.3 -0.0 -0.1 -0.4 -0.7 -0.1 -0.1 0.1 0.0 -0.1 -0.3 0.9 -0.8 0.2
Tense / ‘highly strung’ 0.6 1.1 3.2 -0.3 1.8 -0.8 -0.7 1.0 1.2 1.6 1.5 0.3 -0.0 -0.4 -0.4 0.4 -1.3 1.8 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.5 5.5 -0.2 2.3 -0.4 -0.4 0.4 0.6 1.1 0.6 -0.1 -0.1 0.1 -0.3 0.4 -0.3 0.5 -0.0
Hair/balding pattern: Pattern 4 0.4 1.0 3.3 1.0 -1.2 1.2 1.0 -1.2 -1.1 -1.8 -1.7 0.8 0.3 0.7 0.8 0.3 0.6 -0.5 0.5
Birth weight of first child 0.0 0.1 0.1 -0.2 -0.1 -0.0 -0.1 0.3 0.0 -0.4 0.2 0.4 0.2 -0.3 0.2 0.0 0.3 0.4 0.2
Peak expiratory flow (PEF) 0.6 1.3 3.8 -1.1 1.6 -1.5 -1.0 2.0 1.0 1.3 0.9 -0.3 -0.3 -1.5 -0.7 -0.9 -0.6 1.2 -1.0
Pulse wave reflection index 0.2 0.3 2.2 0.2 1.5 0.4 0.4 0.0 -0.4 -0.2 -0.1 0.4 0.5 -0.2 0.5 0.1 1.0 -0.3 0.3
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.4 0.5 1.2 0.6 0.7 -0.9 -0.6 -0.3 -0.7 -0.5 0.1 1.5 0.1 1.0 0.1 -0.8 0.4
Loud music exposure frequency 0.1 0.2 0.9 0.2 -0.9 0.1 0.4 0.1 -0.1 -0.2 -0.9 0.3 -0.1 0.1 0.4 0.2 -0.4 0.2 -0.1
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 3.0 0.9 -1.2 1.6 1.3 -0.9 -1.7 -1.6 -1.0 1.6 0.2 -0.0 1.1 0.4 1.0 -0.7 0.7
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 2.3 0.8 -0.1 1.3 1.4 -1.3 -1.2 -1.5 -0.8 0.2 0.8 1.5 0.8 0.8 1.3 -1.5 0.8
Blood clot in the leg (DVT) 0.2 0.2 0.9 -0.1 0.1 0.2 -0.0 0.1 -0.2 0.8 -0.5 0.9 0.2 -0.3 0.4 0.6 0.5 0.1 0.7
Medication: Paracetamol 0.9 1.5 4.4 1.3 -1.1 1.0 0.9 -1.0 -0.6 -0.2 -0.8 0.9 1.7 1.8 1.3 2.1 1.2 0.5 1.7
Headache pain in last month 0.9 1.6 4.2 1.4 0.7 0.9 1.1 -0.9 -0.6 -0.1 -0.3 1.0 2.0 1.6 1.4 2.0 1.4 1.2 1.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.9 -0.2 0.9 -1.0 -0.9 1.3 0.6 1.0 0.2 -0.1 -0.2 -1.3 -0.3 -1.0 -0.5 1.4 -0.9
Glaucoma (self-reported) 0.4 0.5 1.5 0.4 -0.1 0.7 0.5 -1.2 -0.6 -1.1 -0.4 -0.2 0.7 0.9 0.2 0.3 1.2 -0.8 0.6
Gout (self-reported) 1.1 1.5 6.9 -1.5 -0.1 -0.6 -0.6 1.1 0.8 0.1 1.4 -1.4 -1.7 -0.8 -1.1 -1.5 -0.4 -2.6 -1.3
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.0 1.4 0.7 1.9 1.3 -2.0 -1.6 -1.6 -0.0 0.3 0.6 1.8 0.6 0.8 1.2 -1.5 0.8
Medication: Amlodipine 0.7 1.0 1.8 1.1 -0.1 1.3 1.1 -1.3 -1.3 -1.0 -1.0 0.9 0.8 1.3 0.8 1.1 0.6 -0.0 0.9
Medication: Ventolin 100micrograms inhaler 0.3 0.4 2.2 0.5 1.0 0.1 0.4 -0.3 0.0 -1.5 0.5 0.2 -0.2 -0.3 0.2 -0.4 -0.7 1.0 -0.3
Birth weight 0.3 0.6 1.8 -0.5 0.0 -0.2 -0.2 0.0 0.1 -1.2 -1.2 -0.3 -1.1 -0.9 -0.5 -1.3 -0.1 -1.3 -1.0
Chronic bronchitis/emphysema (mother) 1.8 2.1 7.8 -1.4 -0.7 -0.9 -0.3 0.8 1.3 -1.2 1.6 -2.1 -1.6 -0.6 -1.1 -2.0 0.0 -2.8 -1.7
High blood pressure (siblings) 0.9 1.2 3.0 1.1 -1.0 1.1 1.7 -0.6 -0.7 -0.9 -0.5 1.0 1.3 0.9 1.5 1.2 1.6 -0.1 1.3
Forced vital capacity (FVC), Best measure 0.4 1.4 3.7 -1.3 1.6 -1.6 -1.0 1.9 1.2 1.4 0.9 -0.3 -0.4 -1.4 -0.7 -1.0 -0.7 1.0 -1.1
Body fat percentage 0.8 3.2 8.3 1.5 0.4 2.1 1.8 -2.9 -2.0 -2.0 -1.8 0.2 1.0 2.5 1.1 1.1 2.3 -2.0 1.6
Leg fat percentage (right) 0.4 1.4 4.1 0.9 0.8 1.3 1.4 -2.0 -1.2 -1.4 -1.3 -0.2 0.6 1.7 0.6 0.5 1.4 -1.4 0.9
Arm fat-free mass (right) 0.2 1.1 4.2 0.9 2.0 0.9 0.5 -1.1 -0.8 -2.0 -1.7 -0.1 0.7 0.8 0.2 -0.2 1.3 0.1 0.3
Exposure to tobacco smoke outside home 0.4 0.5 2.8 -0.2 1.4 -0.2 0.2 -0.4 -0.1 0.2 0.3 -1.5 0.0 1.7 -0.3 0.2 0.1 -1.0 -0.3
Comparative body size at age 10 0.8 2.2 5.9 1.4 1.0 1.4 1.5 -1.4 -1.4 -2.4 -1.5 -0.1 1.5 2.3 1.1 1.1 2.1 -0.4 1.0
Number of full brothers 0.4 0.5 1.4 -0.6 -0.8 -0.9 -1.0 0.4 1.2 1.0 0.7 -0.1 -0.1 -0.8 -0.6 0.1 -0.9 1.0 -0.2
Worry too long after embarrassment 0.1 0.2 0.9 -0.1 1.0 -0.1 -0.7 0.1 0.2 -0.5 0.5 -0.5 -0.2 0.0 -0.6 -0.5 -0.2 -0.0 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 4.8 -0.2 2.2 0.0 -0.0 -0.3 0.0 -1.0 0.9 -1.0 -0.6 0.6 -0.7 -0.6 -0.1 -1.0 -0.6
Wheeze or whistling in the chest in last year 0.4 0.7 2.1 1.1 1.1 0.5 1.0 -0.6 -0.4 -0.3 -0.3 0.8 0.7 0.6 0.9 1.0 -0.3 1.5 0.7
Number of children fathered 0.3 0.3 2.5 0.3 -0.0 -0.1 0.4 0.5 -0.3 0.3 0.3 0.6 0.8 -0.1 0.7 0.3 0.3 1.6 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.3 0.1 -0.4 0.3 0.3 -0.8 -0.6 0.3 -1.0 -0.4 0.6 1.1 0.1 0.6 0.7 -0.7 0.8
Age at first live birth 0.3 0.5 2.5 -0.5 -1.6 0.4 0.0 -0.0 -0.4 -0.3 -1.2 0.2 -0.9 -0.5 -0.1 -0.4 0.0 -1.6 -0.0
Pulse wave peak to peak time 0.2 0.3 1.1 -0.4 -0.8 -0.6 -0.4 1.1 0.3 0.2 0.9 -0.1 -0.0 -0.6 -0.0 -0.4 -0.0 0.7 -0.3
Health satisfaction 0.9 1.1 4.3 0.8 1.3 1.0 0.5 -1.8 -0.7 -2.1 -0.3 -0.7 0.2 1.5 -0.0 0.3 0.9 -1.7 0.1
Shortness of breath walking on level ground 1.1 1.3 4.1 -0.8 0.9 -0.7 -1.0 0.0 0.6 -0.6 0.6 -2.0 -1.5 0.0 -1.5 -1.4 -1.0 -1.8 -1.5
Qualifications: College or University degree 0.5 1.5 6.2 -1.3 -0.4 -1.1 -1.5 1.8 1.1 0.1 0.3 -0.5 -1.1 -2.5 -0.9 -1.8 -0.2 -0.6 -1.3
Eye problems/disorders: None of the above 0.8 0.9 2.4 -1.0 1.4 -1.1 -0.7 1.5 0.8 1.0 0.5 0.2 -0.7 -1.5 -0.3 -0.9 -0.7 0.7 -0.7
Mouth/teeth dental problems: Loose teeth 3.4 4.0 8.0 -2.2 0.6 -2.3 -2.1 1.8 2.4 2.3 2.8 -1.5 -1.9 -2.0 -2.2 -1.6 -2.3 -0.5 -1.8
Emphysema/chronic bronchitis 1.4 1.6 4.6 1.0 -0.3 1.7 1.5 -2.0 -1.1 -2.2 -0.4 0.4 0.3 1.5 0.8 0.6 1.4 -1.8 0.9
Medication for pain relief, constipation, heartburn 0.9 1.6 5.5 -1.0 0.0 -1.4 -1.2 1.6 0.9 1.3 0.0 -0.1 -0.9 -2.3 -0.8 -1.6 -1.5 1.6 -1.3
Neck or shoulder pain in last month 0.6 0.9 3.0 -0.9 -0.1 -1.0 -0.7 0.6 1.0 1.0 0.3 0.4 -1.3 -1.7 -0.4 -0.6 -1.6 0.0 -1.0
Medication: Blood pressure 2.1 3.6 6.8 1.4 -1.4 2.4 2.3 -2.6 -2.0 -2.4 -1.8 1.0 1.1 2.1 1.5 1.5 2.2 -1.9 1.8
Angina (self-reported) 3.6 4.7 13.9 2.2 0.3 2.6 1.9 -3.3 -2.3 -1.9 -1.9 0.7 2.1 3.7 1.4 2.6 1.9 -0.3 2.5
Migraine (self-reported) 1.7 2.1 4.7 1.7 -0.1 1.4 1.3 -1.1 -1.2 -0.6 -0.8 1.0 2.0 2.0 1.6 2.2 1.5 1.0 1.8
Medication: Ibuprofen 0.2 0.3 0.5 -0.1 -0.0 0.2 0.6 0.5 -0.6 0.7 0.7 0.2 0.5 0.6 0.7 0.6 0.7 -0.3 0.5
Medication: Allopurinol 1.6 2.1 4.5 -1.9 -0.7 -1.2 -1.0 1.9 1.3 0.7 1.4 -0.7 -2.0 -2.1 -1.1 -1.8 -1.0 -1.6 -1.6
Medication: Omeprazole 0.2 0.2 0.9 0.6 -0.2 0.6 0.8 -0.6 -0.3 -1.0 -0.2 0.5 -0.2 0.3 0.3 0.3 -0.5 -0.0 -0.2
Medication: Seretide 50 evohaler 0.2 0.2 1.1 -0.2 0.2 -0.5 -0.4 0.7 0.4 0.1 0.1 0.7 0.1 -1.1 0.2 -0.3 -0.1 0.9 -0.1
Mean time to correctly identify matches 0.1 0.1 0.5 -0.0 -0.7 0.3 -0.2 -0.7 -0.1 0.3 0.7 0.3 -0.1 -0.1 -0.1 0.3 -0.1 -0.3 0.3
Heart disease (mother) 2.1 2.5 5.8 1.9 -1.0 2.0 1.6 -2.1 -2.0 -1.7 -2.4 1.4 0.9 1.8 1.2 1.5 1.0 0.0 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.4 -0.6 -0.2 -1.0 -1.0 1.4 1.1 1.3 1.6 0.4 -0.5 -1.8 -0.3 -0.5 -0.5 0.8 -0.5
Whole body fat mass 0.5 2.3 5.6 1.2 1.2 1.7 1.3 -2.4 -1.6 -1.9 -1.7 -0.0 0.9 2.1 0.7 0.8 2.0 -1.5 1.2
Leg fat mass (right) 0.4 1.4 3.8 0.9 1.5 1.2 1.0 -1.9 -1.1 -1.6 -1.5 -0.3 0.6 1.6 0.4 0.4 1.4 -1.0 0.8
Arm predicted mass (right) 0.2 0.8 5.1 0.5 2.3 0.5 0.2 -0.7 -0.4 -1.7 -1.3 -0.4 0.4 0.5 -0.1 -0.5 0.9 -0.0 -0.1
Pulse rate, automated reading 0.7 2.2 6.9 -0.8 -1.7 -1.9 -1.6 1.3 1.5 1.3 0.0 -0.4 -0.8 -1.8 -0.7 -0.7 -2.4 2.6 -1.3
Alcohol intake frequency. 0.6 1.5 6.0 1.5 0.9 1.2 0.2 -2.2 -1.0 -1.2 -1.0 -0.6 1.1 2.5 0.1 1.4 0.4 0.4 1.0
Comparative height size at age 10 0.1 0.4 2.2 0.5 1.0 0.1 -0.4 -0.1 -0.1 -0.3 -0.9 0.5 0.7 -0.6 0.1 -0.2 0.5 1.5 0.3
Number of full sisters 0.3 0.3 1.9 0.3 1.4 -0.1 0.8 0.3 0.2 0.4 0.5 -0.0 0.7 1.0 0.2 0.6 0.2 0.2 0.3
Suffer from ‘nerves’ 0.3 0.5 4.3 0.0 0.9 -0.3 0.2 0.3 0.1 0.9 2.1 0.4 0.1 0.5 0.0 0.8 -0.9 0.9 0.1
Overall health rating 0.2 0.3 1.3 0.1 0.5 -0.2 -0.3 -0.9 0.4 -0.8 0.2 -1.1 0.0 1.1 -0.6 0.3 -0.5 -0.2 -0.2
Chest pain or discomfort 0.7 1.0 2.7 1.2 -0.0 1.2 0.9 -1.5 -0.9 -1.2 -1.0 0.2 1.0 1.6 0.7 1.0 1.0 -0.1 1.0
Had major operations 1.0 1.2 3.5 1.0 0.6 1.4 1.1 -1.9 -1.3 -0.4 -0.2 0.8 0.6 1.6 0.7 1.2 1.0 -1.0 1.2
Age at last live birth 0.7 1.1 2.1 -1.4 -1.3 -1.1 -1.1 1.3 0.7 1.5 0.1 -0.5 -1.1 -1.2 -0.9 -0.7 -1.3 0.0 -0.8
Family relationship satisfaction 1.1 1.3 3.1 1.2 0.2 1.2 0.8 -1.1 -1.1 -0.2 -0.7 0.8 1.6 1.7 1.0 1.8 1.4 0.3 1.5
Leg pain on walking 0.7 0.8 3.1 -0.7 1.8 -0.5 -0.2 0.2 0.1 -0.1 -0.0 -1.6 -1.0 0.4 -0.9 -1.0 -0.5 -1.5 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 4.1 1.1 -0.2 1.4 1.6 -1.7 -1.4 -2.0 -1.9 0.2 0.8 1.2 1.1 0.5 1.3 -0.6 0.7
Commuting to job workplace: Car/motor vehicle 1.9 2.1 3.4 1.5 -1.7 1.6 1.6 -1.5 -1.5 -0.7 -1.6 1.2 1.5 1.7 1.5 1.8 1.2 0.5 1.5
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 4.3 0.4 -1.6 0.8 1.0 -1.1 -0.4 -2.1 -1.1 0.0 0.6 0.4 0.6 -0.1 1.4 -0.8 0.4
Medication: Aspirin 0.8 1.0 4.0 0.5 -0.1 1.1 0.7 -1.6 -0.8 -1.2 -0.2 -0.6 0.2 1.7 -0.0 0.5 1.1 -2.0 0.6
Supplements: Vitamin C 1.1 1.3 2.3 -1.2 1.5 -1.1 -1.2 0.7 0.9 0.8 0.6 -1.5 -1.3 -0.9 -1.4 -1.3 -1.5 -0.4 -1.3
Knee pain experienced in last month 2.1 3.2 6.4 -1.8 2.5 -2.1 -1.5 1.6 2.0 1.7 2.5 -1.8 -1.5 -1.5 -1.8 -1.8 -1.5 -0.4 -1.9
Hypertension (Self-reported) 1.1 3.0 7.8 1.2 -1.5 2.3 2.0 -2.5 -1.9 -2.8 -1.3 0.7 0.3 1.5 1.1 0.6 1.9 -2.5 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 1.4 0.1 0.8 0.2 0.4 -0.1 0.2 0.2 1.2 -0.2 -0.1 0.4 -0.1 0.1 0.0 -0.6 -0.1
Illnesses of father: Heart disease 0.8 1.1 3.5 0.6 -1.1 0.7 0.4 -0.2 -0.8 0.2 -0.5 1.3 1.6 1.0 1.0 1.9 0.9 1.3 1.4
Illnesses of siblings: Diabetes 2.2 2.7 4.6 -1.8 0.9 -2.1 -2.0 1.8 2.1 1.2 1.8 -1.8 -1.5 -1.7 -1.8 -1.6 -1.2 -0.0 -1.6
Smoking status: Previous 3.8 5.7 10.3 -2.8 -0.8 -2.4 -1.5 2.3 2.7 1.4 2.5 -2.0 -2.9 -3.0 -2.4 -3.2 -1.4 -2.7 -2.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.9 1.1 -0.7 1.0 1.1 -0.2 -1.3 -0.5 -1.7 1.7 1.5 0.3 1.3 1.1 1.3 1.7 1.2
Whole body fat-free mass 0.1 0.6 3.7 0.4 1.9 0.4 0.1 -0.7 -0.4 -1.2 -1.4 -0.5 0.2 0.7 -0.3 -0.4 0.7 -0.1 -0.1
Leg fat-free mass (right) 0.1 0.6 2.6 0.2 1.6 0.3 -0.1 -0.6 -0.4 -1.2 -1.3 -0.8 0.1 0.7 -0.4 -0.5 0.9 -0.5 -0.2
Arm fat percentage (left) 0.7 3.0 6.7 1.5 0.4 1.9 1.7 -2.6 -1.8 -1.8 -1.9 0.1 1.3 2.5 1.1 1.3 2.4 -1.4 1.6
Average weekly red wine intake 0.5 0.8 3.3 -0.7 0.8 -0.3 -0.3 0.0 0.4 -0.3 0.5 -1.0 -1.4 -0.3 -1.2 -1.2 -0.5 -1.8 -1.0
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.1 0.2 -0.5 0.6 0.0 -0.2 -0.8 0.2 -0.4 1.1 0.2 -0.1 0.3 0.4 0.5 -0.1 0.5
Mood swings 1.2 2.1 6.2 1.3 1.0 1.6 1.8 -1.8 -1.4 -0.5 -0.3 0.6 1.4 2.5 1.1 1.9 1.5 -0.6 1.9
Loneliness, isolation 1.7 2.4 8.6 1.5 1.4 1.7 1.3 -2.2 -1.6 -0.7 -0.3 0.1 1.4 2.9 0.9 2.0 1.7 -0.7 1.8
Long-standing illness, disability or infirmity 0.5 0.8 2.3 -0.7 0.6 -0.3 -0.8 -0.5 0.2 -0.2 1.0 -1.4 -1.3 0.8 -1.3 -0.3 -1.5 -1.1 -0.7
Ever had bowel cancer screening 0.6 0.7 2.6 0.5 -1.3 0.9 0.9 -1.1 -0.9 -1.6 -0.5 0.4 0.0 0.4 0.6 0.2 0.8 -1.1 0.5
Diabetes diagnosed by doctor 1.0 1.7 7.9 -0.6 0.1 0.1 -0.8 -1.0 0.1 -1.5 0.3 -2.4 -1.5 0.7 -1.7 -1.2 -0.3 -2.8 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 1.0 -0.0 1.0 -0.1 -0.3 -0.1 0.2 0.5 1.0 -0.0 -0.0 0.5 -0.3 0.5 -0.3 0.1 0.3
Friendships satisfaction 2.5 3.1 5.8 2.0 -0.3 1.8 1.9 -2.1 -1.7 -1.1 -1.2 1.0 2.2 2.4 1.8 2.3 2.0 0.2 1.9
Qualifications: nursing, teaching 0.2 0.3 1.7 0.1 -0.8 0.2 -0.4 0.6 -0.4 0.4 -0.0 1.3 -0.1 -1.1 0.2 -0.1 -0.0 1.0 0.3
Commuting to job workplace: Walk 0.2 0.2 0.9 0.0 -0.2 -0.1 0.2 0.2 -0.0 -0.6 -0.5 -1.0 -0.6 0.1 -0.1 -0.5 -0.4 -0.5 -0.6
Eye problems/disorders: Cataract 2.8 3.2 8.8 2.1 -3.0 2.0 2.1 -1.8 -1.9 -1.8 -1.8 1.3 1.7 1.4 1.8 1.3 1.7 0.1 1.3
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 5.2 2.0 -2.3 1.3 1.1 -1.3 -1.4 -1.1 -1.5 1.9 1.9 0.8 1.6 1.8 0.9 2.1 1.5
Medication for cholesterol 0.1 0.2 0.7 0.2 -0.9 0.1 0.0 -0.1 0.2 0.5 -0.6 0.1 0.5 0.6 0.1 0.6 0.4 -0.4 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.0 0.9 -0.9 1.0 1.2 -0.9 -0.9 -0.3 0.0 0.3 0.9 1.4 0.9 1.0 1.0 -0.6 0.9
Back pain experienced in last month 0.6 0.9 3.4 -0.8 0.4 -1.2 -1.0 1.1 1.2 1.8 1.5 -0.8 -0.2 -0.4 -0.5 -0.1 -0.8 0.8 -0.4
Mineral and other dietary supplements 0.6 0.8 3.6 -0.8 1.9 -0.8 -0.5 0.6 0.6 0.7 -0.3 -1.2 -1.1 -0.4 -0.8 -1.0 -0.8 -0.7 -1.1
Breast cancer (self-reported) 0.5 0.6 3.7 0.0 0.6 -0.5 -0.8 1.1 0.2 1.3 0.4 0.6 0.7 -0.5 0.0 0.4 -0.1 1.9 0.5
Asthma (self-reported) 0.2 0.3 1.5 0.1 -0.7 -0.3 -0.0 -0.1 0.3 -0.7 -0.2 0.2 -0.4 -0.9 0.0 -0.5 -1.2 0.8 -0.4
Osteoporosis (self-reported) 0.1 0.2 1.3 0.1 1.1 0.3 -0.1 -0.3 -0.1 -0.3 -0.0 0.2 0.3 0.1 0.1 0.3 0.5 -0.4 0.6
Osteoarthritis (self-reported) 1.0 1.4 4.0 0.6 0.1 1.1 1.2 -1.3 -1.1 -2.0 -0.1 -0.6 0.7 1.6 0.7 0.3 2.0 -1.9 0.6
Medication: Aspirin 1.3 1.6 6.3 0.7 0.1 1.5 0.8 -2.1 -1.2 -1.6 -0.7 -0.7 0.1 2.1 -0.1 0.6 1.3 -2.5 0.7
Medication: Gliclazide 0.7 0.8 3.2 0.4 -0.4 0.9 0.7 -1.5 -0.6 -1.5 -0.4 -1.0 -0.1 1.4 -0.0 0.3 0.7 -1.8 0.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.7 -0.1 0.3 -0.1 -0.0 -0.2 -0.0 -0.7 -0.4 -0.8 -0.4 0.2 -0.4 -0.8 0.0 -0.8 -0.5
Smoking status: Current 0.6 1.0 9.4 0.2 3.1 0.2 0.6 -0.6 -0.3 -0.7 -0.1 -1.0 0.5 1.6 0.2 0.3 0.9 -0.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 5.1 -1.2 1.4 -1.9 -1.3 2.3 1.7 1.7 2.2 -0.2 0.1 -1.6 -0.7 -0.6 -0.5 1.6 -0.6
Whole body water mass 0.1 0.6 3.5 0.4 1.9 0.3 0.1 -0.6 -0.3 -1.2 -1.3 -0.5 0.3 0.7 -0.3 -0.4 0.7 -0.0 -0.1
Leg predicted mass (right) 0.1 0.6 2.9 0.2 1.7 0.3 -0.1 -0.6 -0.4 -1.3 -1.3 -0.8 0.1 0.7 -0.4 -0.6 0.9 -0.5 -0.2
Arm fat mass (left) 0.6 2.4 5.2 1.5 0.9 1.7 1.5 -2.3 -1.6 -2.0 -2.0 0.0 1.2 2.3 0.9 1.0 2.1 -1.0 1.4
Number of self-reported non-cancer illnesses 1.1 1.8 7.4 0.6 -1.0 1.7 1.2 -2.4 -1.6 -1.6 -0.3 0.1 -0.3 1.8 0.2 0.7 0.8 -2.7 0.8
Average weekly champagne plus white wine intake 0.6 0.8 2.1 1.2 0.8 1.1 0.6 -0.9 -1.2 -1.2 -1.4 0.8 1.0 0.5 0.7 0.5 1.0 0.3 0.6
Miserableness 0.6 1.0 4.0 -0.6 2.0 -0.7 -0.2 0.4 0.7 1.6 1.8 -1.0 -0.6 0.6 -0.8 0.2 -1.0 -0.6 -0.5
Guilty feelings 0.5 0.7 2.2 -0.2 1.1 -0.8 -1.0 0.1 0.7 1.5 1.1 -1.0 0.1 0.8 -0.9 0.5 -1.0 0.9 0.0
Wears glasses or contact lenses 0.0 0.0 0.1 -0.1 0.0 -0.0 0.2 -0.0 -0.0 -0.1 -0.2 -0.3 -0.3 0.1 -0.0 -0.0 -0.2 -0.1 -0.2
Ever taken oral contraceptive pill 0.4 0.4 2.8 0.3 -1.7 -0.2 0.4 -0.1 -0.1 -0.1 -0.9 -0.3 0.7 0.6 0.3 0.5 -0.1 1.0 0.3
Hearing aid user 0.9 1.1 5.1 -0.1 0.4 -0.8 -0.7 0.8 0.8 2.1 0.8 1.1 0.6 -1.1 0.2 0.7 -0.6 2.3 0.6
Mother’s age at death 1.0 1.3 4.7 -1.2 -0.7 -0.7 -0.5 0.9 1.0 0.7 0.5 0.3 -1.9 -2.2 -0.6 -1.4 -1.0 -1.6 -1.2
Financial situation satisfaction 0.5 0.6 3.8 0.2 2.0 0.4 0.4 -1.0 -0.4 -0.7 0.1 -0.7 -0.6 0.9 -0.4 -0.4 -0.1 -1.4 -0.6
Tinnitus: Yes, now most or all of the time 5.0 5.8 9.8 -2.4 3.1 -2.1 -2.3 1.9 2.2 2.1 2.5 -1.9 -3.1 -1.7 -2.9 -2.2 -3.0 -1.4 -2.7
Commuting to job workplace: Public transport 1.7 2.0 6.7 -1.8 0.7 -1.1 -1.1 0.9 1.2 0.5 0.8 -0.9 -1.8 -2.2 -1.2 -2.1 -0.0 -2.6 -1.4
Eye problems/disorders: Glaucoma 0.1 0.1 0.4 0.1 0.2 0.4 -0.2 -0.6 -0.3 -0.5 -0.0 -0.0 0.6 0.2 -0.1 0.1 0.6 0.1 0.5
Medication: Blood pressure 0.2 0.3 2.0 0.0 0.2 0.4 0.1 -0.4 -0.3 -1.4 0.3 -0.3 -0.6 -0.2 -0.3 -0.9 0.4 -1.1 -0.6
Pain type(s) experienced in last month: Hip pain 2.5 3.2 12.0 1.9 -0.1 1.7 1.5 -2.3 -2.0 -0.9 -2.3 0.1 2.0 3.5 1.3 2.2 1.2 0.3 1.6
Supplements: Fish oil (including cod liver oil) 1.9 2.5 14.2 1.6 -3.8 1.4 1.3 -1.1 -1.3 -1.5 -1.4 1.8 1.4 0.5 1.5 1.1 0.8 1.2 1.1
High cholesterol (Self-reported) 0.3 0.5 2.0 0.5 -0.4 0.7 0.7 -1.4 -0.6 -0.7 0.2 0.3 0.1 0.9 0.5 1.0 0.2 -0.7 0.6
Medication: Bendroflumethiazide 0.7 1.0 3.7 0.8 -0.6 1.3 1.2 -1.4 -1.0 -1.9 -0.4 -0.1 0.2 1.1 0.5 0.1 1.1 -1.4 0.4
Medication: Paracetamol 1.4 2.2 6.2 1.5 -0.3 1.2 1.2 -1.4 -0.8 -0.1 -0.8 1.0 2.2 2.3 1.6 2.5 1.6 0.7 2.0
Medication: Lisinopril 1.1 1.4 4.4 0.7 0.1 1.5 1.1 -1.2 -1.3 -2.0 -0.1 0.8 0.5 0.6 0.8 0.4 2.1 -1.9 1.0
Medication: Atorvastatin 0.1 0.1 0.5 -0.1 0.1 -0.3 -0.0 0.4 0.3 0.5 0.7 -0.2 -0.3 -0.0 -0.0 0.2 -0.7 0.6 -0.2
Illnesses of father: High blood pressure 0.7 0.8 3.1 -1.0 -0.5 -0.9 -0.2 1.5 0.7 1.8 0.9 0.8 -0.3 -1.7 0.2 -0.4 -0.3 0.7 -0.3
Alcohol drinker status: Never 0.8 1.0 2.3 -1.0 -0.9 -1.1 -1.5 0.4 1.1 0.5 0.1 -1.4 -1.0 -0.8 -1.1 -1.1 -1.3 0.0 -1.0
Ever smoked 2.3 4.1 6.3 -2.4 0.9 -2.2 -1.3 2.0 2.2 1.5 2.5 -1.7 -2.3 -2.4 -1.9 -2.5 -1.4 -1.9 -2.2
Basal metabolic rate 0.2 0.8 3.2 0.7 1.8 0.7 0.4 -1.1 -0.7 -1.5 -1.6 -0.4 0.5 1.0 -0.0 -0.2 1.1 -0.2 0.2
Leg fat percentage (left) 0.5 1.6 4.6 0.8 1.0 1.3 1.3 -2.1 -1.2 -1.9 -1.4 -0.6 0.4 1.7 0.4 0.2 1.5 -1.8 0.7
Arm fat-free mass (left) 0.1 0.6 4.2 0.5 2.0 0.4 0.1 -0.7 -0.3 -1.4 -1.3 -0.6 0.2 0.7 -0.4 -0.5 0.6 -0.1 -0.2
Number of operations (self-reported) 0.7 1.1 2.0 1.1 -0.6 1.2 1.4 -1.4 -0.8 -1.2 -1.0 1.4 0.7 0.5 1.2 1.0 0.7 -0.0 1.1
Average weekly beer plus cider intake 1.6 2.3 5.7 -1.5 0.1 -2.1 -1.7 2.0 2.2 1.7 2.4 -1.3 -0.6 -1.5 -1.2 -1.3 -0.7 0.8 -1.1
Irritability 0.5 0.8 2.3 0.6 -0.8 0.5 0.8 -0.3 -0.4 1.1 -0.6 1.5 0.9 0.1 1.1 1.3 -0.2 1.5 1.0
Risk taking 0.2 0.3 1.6 0.2 0.8 0.3 0.5 -0.8 -0.7 -0.1 0.7 -0.5 0.2 1.3 -0.1 0.2 0.5 -0.7 0.3
Ever had prostate specific antigen (PSA) test 0.8 0.9 3.1 -0.6 -0.5 -0.7 -1.3 0.8 0.5 -0.0 -0.1 -0.0 -1.2 -1.8 -0.8 -1.3 -1.3 0.7 -1.2
Fractured/broken bones in last 5 years 4.3 5.6 11.1 2.6 -1.4 2.9 2.9 -3.2 -2.8 -3.3 -2.4 1.7 1.5 2.6 2.2 2.0 2.1 -0.6 2.1
Age started oral contraceptive pill 0.4 0.5 2.4 0.2 1.0 0.5 0.2 -1.1 -0.4 -1.6 -0.4 -0.4 0.2 0.6 -0.0 -0.3 1.0 -1.2 0.2
Diastolic blood pressure, automated reading 0.9 2.7 7.1 1.6 -2.7 1.8 1.9 -2.0 -1.8 -2.1 -2.1 1.0 0.7 1.3 1.4 0.9 1.5 -0.7 1.2
Ever depressed for a whole week 0.3 0.3 0.8 0.5 0.4 0.4 -0.1 -0.7 -0.7 -0.5 -0.8 0.2 0.6 0.8 0.3 0.7 0.3 0.9 0.6
Unable to work because of sickness or disability 0.5 0.7 3.0 0.2 0.3 0.4 0.0 -0.6 -0.2 -1.4 -0.7 -1.5 0.1 1.7 -0.5 -0.0 0.6 -1.3 -0.2
Commuting to job workplace: Cycle 0.2 0.2 0.6 0.0 -0.8 -0.0 0.6 0.6 0.2 -0.5 0.5 -0.0 -0.2 -0.6 0.5 -0.3 0.5 -0.2 -0.1
Myopia 0.4 0.6 3.3 -0.6 -1.8 -0.8 -0.2 1.4 0.4 -0.0 0.2 -0.2 -0.1 -1.4 -0.0 -0.9 0.6 0.3 -0.5
Vascular/heart problems diagnosed by doctor 1.7 4.5 11.1 -1.7 0.8 -2.8 -2.3 3.3 2.5 3.2 1.6 -0.4 -0.8 -2.6 -1.3 -1.2 -2.5 2.6 -1.6
Cholesterol lowering medication 0.4 0.6 2.5 0.7 1.5 0.8 0.8 -1.0 -0.8 -1.6 0.2 -0.3 0.1 1.2 0.3 0.4 0.4 -0.5 0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.3 -0.2 0.1 -0.4 -0.0 0.3 0.6 -1.0 0.9 -0.6 -1.0 -0.4 -0.6 -0.8 -0.9 -0.7 -1.2
Pain experienced in last month 0.2 0.4 2.7 0.2 -1.6 0.3 -0.1 0.1 -0.3 -0.4 -1.1 0.7 -0.0 -0.7 0.2 -0.2 -0.0 0.8 0.1
Supplements: Calcium 0.3 0.3 0.9 -0.3 -0.8 -0.3 -0.7 0.2 0.8 0.0 1.0 0.5 -0.2 -1.0 -0.4 -0.1 -0.5 0.2 0.1
Basal cell carcinoma (self-reported) 0.3 0.4 1.1 -0.6 -0.5 -0.5 -0.8 0.7 1.0 -0.0 1.0 -0.5 -0.3 -0.5 -0.6 -0.5 0.6 -1.0 -0.3
Heart attack/myocardial infarction (self-reported) 2.4 3.1 4.6 1.9 0.3 2.1 2.0 -2.0 -1.9 -1.5 -1.5 1.4 2.0 2.2 1.7 2.1 1.8 0.5 2.1
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.8 -0.1 0.3 0.2 -0.1 0.1 -0.2 0.7 -0.6 0.9 0.1 -0.4 0.3 0.5 0.4 0.1 0.6
Heart disease (siblings) 0.8 0.9 3.4 0.4 -0.5 0.8 0.5 -1.5 -0.5 -1.3 -0.2 -1.0 0.3 1.8 -0.0 0.7 1.0 -1.8 0.6
Alcohol drinker status: Previous 1.3 1.4 4.4 -0.7 0.9 -1.0 -1.8 0.1 1.1 0.5 0.7 -2.1 -1.2 0.1 -2.0 -0.9 -1.7 -0.4 -1.2
Pack years of smoking 0.4 0.6 4.3 0.4 2.1 0.5 -0.3 -1.3 -0.2 -0.7 -0.3 -0.4 0.5 1.1 -0.2 0.6 0.4 -0.3 0.5
Impedance of whole body 1.1 5.8 13.2 2.4 -2.1 2.6 2.5 -2.1 -2.5 -0.1 -1.2 3.6 2.6 1.4 3.0 3.2 2.3 0.8 3.3
Leg fat mass (left) 0.4 1.7 4.5 1.0 1.4 1.3 1.1 -2.1 -1.2 -2.0 -1.7 -0.4 0.6 1.7 0.4 0.3 1.6 -1.2 0.8
Arm predicted mass (left) 0.1 0.6 4.6 0.4 2.1 0.3 0.0 -0.6 -0.2 -1.3 -1.2 -0.6 0.2 0.7 -0.4 -0.5 0.6 -0.1 -0.2