Hub : Genes

ZNF221

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.120	0.0290	1.8e-09	0.074	0.106	0.107	0.111	0.110	2.6e-09	8.5e-13	5.7e-13	2.2e-13	2.7e-13
2	GTEx	Adrenal Gland	0.231	0.0954	8.9e-03	0.011	NA	0.019	NA	0.001	1.2e-01	NA	6.8e-02	NA	2.9e-01
3	GTEx	Stomach	0.125	0.0530	7.6e-03	0.013	NA	0.019	NA	0.006	7.6e-02	NA	4.0e-02	NA	1.6e-01
4	TCGA	Pancreatic Adenocarcinoma	0.263	0.1050	8.6e-03	-0.002	0.051	0.047	NA	0.017	4.0e-01	3.5e-03	4.6e-03	NA	6.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.3	0.2	0.3	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.2	0.6	0.4	-0.6
Depressed Affect (Nagel 2018)	0.3	0.7	2.2	-0.5	1.5	0.2	-0.4
Depression (Nagel 2018)	0.3	0.5	1.1	0.1	1.0	-0.3	-0.9
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.6	-0.3	-1.3	0.1	1.0
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.1	0.1	0.3	-0.8
Schizophrenia (2018)	0.1	0.1	0.3	-0.0	0.6	0.3	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	0.3	0.2	-0.4	0.3
Worry (Nagel 2018)	0.1	0.2	0.3	0.5	-0.5	-0.3	-0.4
Alzheimer’s Disease (in mother)	1.6	1.8	4.4	-1.5	0.3	-2.1	0.8
Alzheimer’s Disease (in father)	1.2	1.3	3.2	-1.2	-0.4	-0.5	1.8
Alzheimer’s Disease (including proxy)	3.4	4.9	8.5	-2.5	-0.3	-2.9	2.2
Crohns Disease (2017)	0.4	0.9	1.8	0.1	-1.3	1.0	-0.9
Irritable Bowel Disease (IBD)	0.2	0.5	1.7	-0.4	-0.0	-0.1	-1.3
Ulcerative Colitis (UC)	0.5	0.9	1.6	-0.5	1.0	-0.8	-1.2
Major Depression (MDD)	1.2	1.5	4.8	-2.2	-0.7	-0.7	0.3
Reaction Time	0.4	0.8	1.8	1.1	0.1	1.4	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.1	3.3	-0.4	-1.8	-0.7	0.6
Breast Cancer	2.2	5.3	15.3	-3.9	-1.9	-1.4	0.4
Ovarian Cancer	0.5	0.6	1.9	1.4	-0.1	0.3	-0.6
Prostate Cancer	1.0	1.4	3.2	-1.8	0.1	-1.1	1.1
Age at First Birth	0.2	0.3	1.2	0.0	0.0	1.1	-0.2
Bipolar Disorder (2011)	1.6	1.5	2.7	0.6	1.3	1.2	-1.6
Body Mass Index (BMI) (2010)	1.2	1.6	2.3	-1.5	-1.0	-1.4	1.0
Coronary Artery Disease (CAD)	1.6	1.9	7.1	-0.4	2.7	-0.4	-0.1
Crohns Disease (2012)	0.5	0.8	1.1	1.0	-1.1	0.7	-0.7
Mean Putamen Volume	1.3	1.5	2.8	-1.7	0.2	-0.7	1.6
Fasting Glucose	1.5	1.8	3.3	1.5	1.8	-0.2	-1.3
HbA1C	2.1	2.3	8.5	0.7	0.4	2.9	-0.0
HDL Cholesterol	0.5	0.9	2.3	0.4	-0.9	0.4	1.5
LDL Cholesterol	1.7	2.6	3.8	-1.7	-1.5	-1.3	1.9
Lupus	0.2	0.3	1.0	0.2	-1.0	0.1	-0.4
Neuroticism (2016)	0.4	0.6	1.1	0.4	-0.8	-0.6	-1.1
Primary Biliary Cirrhosis	0.6	0.9	3.3	0.4	1.8	-0.2	0.1
Rheumatoid Arthritis	0.2	0.2	0.7	-0.0	-0.3	-0.9	0.4
Schizophrenia (2014)	0.0	0.1	0.2	0.2	0.5	0.3	-0.0
Triglycerides	0.3	0.6	0.8	-0.8	-0.7	-0.6	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	-0.4	0.9	0.1	-0.5
Ulcerative Colitis	1.2	1.8	3.8	-1.7	0.7	-2.0	0.1
Blood Eosinophil Count	0.4	3.0	7.7	-0.8	0.0	-1.9	2.8
Blood Platelet Count	0.4	4.4	11.3	-2.1	-0.5	-1.2	3.4
Blood Red Count	0.7	6.3	11.2	-3.3	0.3	-3.3	1.8
Blood White Count	1.3	9.3	28.3	-2.4	-5.3	-1.2	1.3
Heel T-Score	0.3	2.7	10.3	-0.0	-0.6	-3.2	0.2
BMI	0.1	0.5	1.0	-0.9	-1.0	-0.2	0.4
Height	0.5	9.0	19.9	2.8	2.9	4.5	0.2
Waist Hip Ratio (WHR)	1.2	5.3	11.8	-1.8	3.4	-1.2	2.1
Systolic Blood Pressure	0.4	2.0	4.0	-1.5	-0.4	-2.0	1.3
Smoking Status	0.3	0.7	1.8	1.0	-0.2	1.3	-0.0
Allergy or Eczema	0.2	0.4	0.7	-0.8	0.1	-0.6	0.8
Cardiovascular Disease	1.5	4.9	7.0	-2.3	0.8	-2.5	2.6
Hypothyroidism (self reported)	0.7	1.6	6.0	-0.4	2.5	-0.1	-0.4
Respiratory disease	0.1	0.3	0.4	0.5	0.4	0.6	0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.0	1.9	-1.4	0.7	-1.3	0.1
Lung FEV1/FVC ratio	0.0	0.1	0.5	-0.0	0.7	-0.1	-0.0
Lung FVC	0.3	1.4	3.1	-0.6	-1.4	-0.2	1.8
Neuroticism	0.0	0.1	0.1	0.1	0.0	-0.3	-0.3
Chronotype (morning person)	0.1	0.2	0.6	0.3	0.4	-0.4	-0.8
Hair Pigment	0.2	6.6	15.3	1.6	0.2	2.9	-3.9
Tanning	0.3	3.8	7.7	-1.0	2.8	-2.5	0.6
Hand grip strength (left)	1.0	2.6	9.8	0.4	-3.1	0.4	0.4
Number of treatments/medications taken	1.3	2.3	3.7	-1.4	0.2	-1.9	1.9
Average weekly spirits intake	0.7	0.8	2.9	0.5	0.1	-0.2	1.7
Sensitivity / hurt feelings	0.3	0.6	1.5	0.4	-0.5	0.6	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	0.1	0.5	0.9	0.1
Hearing difficulty/problems: Yes	0.8	1.2	3.2	1.0	-1.8	-0.1	0.6
Relative age of first facial hair	0.3	0.6	1.1	-0.7	-0.2	-0.8	1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.8	-1.4	-0.6	0.2	-0.3
Ever used hormone-replacement therapy (HRT)	2.8	3.5	13.4	0.1	3.7	0.0	-0.7
Ever had hysterectomy (womb removed)	2.9	3.3	9.1	-0.6	3.0	-1.7	-1.0
Systolic blood pressure, automated reading	0.2	0.6	1.6	-0.6	0.5	-1.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	-0.6	0.3	0.3	0.1
Angina	0.5	0.7	2.1	0.4	-0.4	1.4	-0.6
Medication for hormone replacement therapy	1.7	1.9	4.5	0.5	-0.2	2.1	-1.6
Vitamin and mineral supplements	0.5	0.7	2.0	1.4	-0.6	-0.1	0.5
Supplements: Zinc	0.5	0.5	1.7	0.1	0.5	0.3	-1.3
Medication: Co-codamol	0.6	0.7	1.0	-0.2	-1.0	1.0	0.8
Medication: Metformin	0.6	0.9	2.3	-1.5	0.7	-0.7	-0.4
Diabetes (father)	0.9	1.1	2.4	1.3	-0.2	0.5	-1.5
Diabetes (mother)	0.3	0.4	0.8	-0.5	0.4	0.5	0.9
Severe depression (siblings)	0.8	0.9	2.4	-1.6	-0.8	-0.7	-0.4
Pack years adult smoking proportion	0.3	0.5	0.9	0.0	-1.0	-0.2	0.9
Impedance of leg (right)	0.1	0.5	1.9	1.4	0.3	-0.2	-0.1
Leg fat-free mass (left)	0.2	1.2	3.5	-0.5	-0.5	1.9	0.9
Trunk fat percentage	0.1	0.5	1.4	0.7	1.2	0.0	0.3
Hand grip strength (right)	0.8	2.2	7.6	-0.3	-2.8	1.0	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.4	0.8	-0.1	0.5
Current tobacco smoking	1.3	2.2	4.8	1.8	-0.7	2.2	-0.5
Average weekly fortified wine intake	1.1	1.2	2.4	-1.6	0.5	-1.5	-0.1
Maternal smoking around birth	0.7	1.0	2.9	-0.4	0.7	-0.7	1.7
Fed-up feelings	0.3	0.5	1.0	-0.5	1.0	0.8	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.0	0.4	1.4	-0.8	-0.6
Relative age voice broke	1.3	2.1	4.8	-1.4	0.2	-1.2	2.2
Taking other prescription medications	0.5	0.8	1.2	-0.9	1.0	-0.2	1.1
Age when periods started (menarche)	0.2	0.4	0.6	-0.8	-0.2	-0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	0.8	1.3	-0.8	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.1	-0.6	-1.4	-1.0	-0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.7	-0.8	0.3	-0.6	-0.8
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.1	0.4	-0.7	-0.6
Serious illness, injury or assault to yourself	0.9	1.1	2.8	-0.3	1.7	-0.7	1.0
High blood pressure	1.4	4.0	6.3	-1.8	1.0	-2.5	2.4
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.6	0.1	-0.7	-0.2
Multivitamins +/- minerals	0.3	0.3	1.2	-0.0	-0.2	0.4	-1.1
Stomach or abdominal pain in last month	0.9	1.1	3.1	-1.0	-1.8	0.3	-0.2
Supplements: Glucosamine	0.1	0.1	0.2	-0.3	-0.2	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.8	-1.5	1.7	-0.1	-0.1
Medication: Atenolol	0.4	0.5	1.2	1.1	0.0	0.5	0.7
Medication: Levothyroxine sodium	0.6	0.9	3.1	-0.3	1.8	-0.8	0.0
Sitting height	0.3	1.8	6.1	0.6	-0.5	2.5	0.8
Chronic bronchitis/emphysema (father)	1.0	1.2	2.6	-0.8	0.9	-0.8	-1.6
High blood pressure (mother)	1.2	1.7	3.6	-0.8	-1.6	-0.1	1.9
Body mass index (BMI)	0.2	0.8	1.6	-1.0	-0.4	-0.6	1.2
Impedance of leg (left)	0.3	1.2	4.5	2.1	-0.2	0.1	-0.6
Leg predicted mass (left)	0.2	1.2	3.5	-0.5	-0.5	1.9	1.0
Trunk fat mass	0.1	0.5	0.7	0.5	0.8	0.8	0.6
Waist circumference	0.2	0.7	2.2	-0.1	1.5	-0.3	0.8
Number of incorrect matches in round	0.4	0.7	2.3	-0.5	0.4	-0.1	1.5
Past tobacco smoking	0.4	0.7	1.6	-1.1	0.0	-1.2	0.1
Alcohol usually taken with meals	1.0	1.6	5.5	0.6	0.2	-0.6	-2.4
Nervous feelings	0.3	0.6	1.8	1.4	-0.5	0.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.3	0.2	2.1	-0.3	0.1
Hearing difficulty/problems with background noise	0.4	0.6	1.2	0.5	-1.1	-0.5	-0.9
Hair/balding pattern: Pattern 2	0.6	0.7	2.8	-0.0	-0.4	-1.7	0.0
Had menopause	2.4	3.0	11.8	-0.2	3.4	-0.0	0.1
Had other major operations	1.2	1.4	2.6	-0.7	1.5	0.5	1.6
Forced vital capacity (FVC)	0.3	1.3	2.8	0.5	-1.7	1.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.3	-1.0	0.2	-2.1	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.5	-0.1	-0.6	0.5
Qualifications: None of the above	0.1	0.1	0.2	-0.1	0.3	0.4	-0.5
Financial difficulties in last 2 years	0.5	0.6	1.4	0.5	0.1	0.9	-1.2
Mouth/teeth dental problems	1.1	1.6	4.5	-0.3	-1.4	-0.2	2.1
Heart attack	0.5	0.7	2.6	0.2	-0.2	1.6	0.1
Allergy	0.0	0.1	0.3	-0.6	-0.3	0.2	0.1
Pain all over the body in last month	0.5	0.5	1.5	0.6	-0.5	1.2	-0.0
Diabetes (self-reported)	0.9	1.4	2.9	-1.7	1.4	-0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	-0.5	0.2	0.4	0.5
Medication: Ramipril	1.3	1.7	4.3	-0.9	-1.3	-0.2	2.1
Medication: Simvastatin	0.4	0.6	1.3	-1.1	0.5	-0.9	-0.5
Fluid intelligence score	0.4	0.9	2.7	0.2	0.1	-1.6	-0.9
Illnesses of siblings	0.3	0.5	1.0	1.0	-0.1	0.9	-0.1
Neuroticism score	0.0	0.1	0.2	0.3	-0.4	-0.0	0.1
Weight	0.1	0.7	1.3	-0.1	-0.1	1.1	1.1
Impedance of arm (right)	0.5	2.3	4.1	2.0	1.3	0.7	-1.7
Arm fat percentage (right)	0.0	0.1	0.4	0.2	0.6	-0.2	0.3
Trunk fat-free mass	0.4	2.4	4.5	-0.5	-1.0	2.1	1.9
Hip circumference	0.1	0.2	0.5	0.7	-0.2	0.6	0.3
Time employed in main current job	2.5	2.9	5.8	-2.3	0.5	-2.4	0.0
Alcohol intake versus 10 years previously	0.4	0.6	2.4	-0.2	0.1	1.6	-0.1
Father’s age at death	2.1	2.8	7.9	-1.5	2.8	-1.1	-0.3
Worrier / anxious feelings	0.3	0.6	2.0	0.6	-1.4	0.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.4	0.6	-0.2	-0.2
Falls in the last year	2.2	3.0	6.5	-2.5	1.4	-1.8	0.7
Hair/balding pattern: Pattern 3	1.1	1.7	4.5	1.1	0.8	2.1	-0.5
Number of live births	0.2	0.3	0.6	0.5	-0.2	-0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.5	0.1	-1.2	0.6	0.5
Pulse rate	0.4	0.7	0.9	-0.8	-0.8	-0.7	-1.0
Happiness	0.2	0.2	0.5	-0.4	-0.7	0.2	0.5
Noisy workplace	0.2	0.3	0.5	0.7	-0.7	0.2	-0.1
Qualifications: A levels/AS levels or equivalent	1.4	3.1	5.4	1.6	-2.0	0.6	-2.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.9	0.0	0.6	-1.7	0.9
Mouth/teeth dental problems: Dentures	2.4	4.1	6.6	1.9	0.4	2.6	-2.4
Asthma	0.0	0.0	0.1	0.0	-0.1	0.3	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	3.2	-1.3	-1.8	-1.4	-0.1
Medication: Cholesterol lowering	1.2	1.8	3.0	-1.4	-0.2	-1.7	1.4
Depression (self-reported)	0.7	0.8	2.4	0.5	-0.4	0.6	1.5
Medication: Lansoprazole	1.4	1.6	5.1	0.7	2.3	1.0	-0.0
Prospective memory result	1.2	1.5	4.4	-1.0	0.4	0.6	-2.1
Lung cancer (father)	0.2	0.2	0.4	0.1	0.6	-0.6	0.3
Illnesses of mother	1.4	1.8	3.6	1.9	0.3	1.5	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.5	-1.2	-1.0	0.0	1.2
Pulse wave Arterial Stiffness index	1.5	1.8	2.3	-1.5	1.4	-1.4	0.9
Impedance of arm (left)	0.5	2.5	3.7	1.7	1.9	0.1	-1.9
Arm fat mass (right)	0.1	0.2	0.6	0.1	0.4	0.4	0.7
Trunk predicted mass	0.4	2.3	4.6	-0.4	-1.0	2.1	1.9
Standing height	0.5	5.1	16.2	1.8	0.8	4.0	0.4
Length of working week for main job	0.7	0.8	2.7	0.0	-1.6	0.6	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.4	-0.1	-0.6	-0.0
Breastfed as a baby	0.8	0.9	2.8	-0.6	1.7	-0.7	0.1
Tense / ‘highly strung’	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.6	1.1	0.5	-0.1
Hair/balding pattern: Pattern 4	0.7	1.6	5.1	-2.2	0.1	-1.1	0.4
Birth weight of first child	0.3	0.5	1.7	-1.3	0.4	0.1	0.2
Peak expiratory flow (PEF)	0.5	1.3	2.4	1.6	-0.2	0.9	-1.3
Pulse wave reflection index	3.2	4.0	5.8	-2.4	0.6	-2.4	2.0
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.7	-1.6	-1.0	0.2	1.2
Loud music exposure frequency	0.9	0.9	1.8	-0.4	-1.3	1.1	0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.3	-0.4	-0.7	-0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.0	0.2	-0.4	0.4	-1.4
Blood clot in the leg (DVT)	1.7	2.3	4.5	2.1	1.3	1.5	-0.8
Medication: Paracetamol	0.5	0.8	1.9	0.2	-1.4	0.8	0.9
Headache pain in last month	1.1	2.0	3.7	1.7	-0.7	1.9	0.9
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	5.6	1.9	0.2	2.4	-2.0
Glaucoma (self-reported)	1.4	1.6	4.7	-1.1	-0.2	-0.6	2.2
Gout (self-reported)	1.1	1.5	2.9	-0.7	-1.1	-1.1	1.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	4.1	0.1	2.0	0.8	-0.6
Medication: Amlodipine	0.7	0.9	1.6	0.6	0.9	-1.2	1.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.4	0.8	-0.2	1.5	-0.6
Birth weight	1.1	2.3	3.8	1.8	0.4	1.9	-1.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	0.5	-1.2	-0.3	-0.7
High blood pressure (siblings)	0.4	0.6	1.0	-0.8	0.3	-1.0	0.7
Forced vital capacity (FVC), Best measure	0.3	0.9	2.5	-0.4	-1.6	0.8	0.6
Body fat percentage	0.1	0.3	0.7	0.6	0.8	-0.2	0.4
Leg fat percentage (right)	0.1	0.4	1.1	0.1	-0.0	-0.7	1.0
Arm fat-free mass (right)	0.3	1.5	3.3	-0.1	-0.6	1.8	1.5
Exposure to tobacco smoke outside home	0.9	1.2	3.4	0.1	-0.9	0.7	1.8
Comparative body size at age 10	0.3	0.9	1.8	-0.7	-1.1	-0.2	1.3
Number of full brothers	0.8	1.0	3.3	-0.4	-1.8	-0.2	-0.8
Worry too long after embarrassment	0.2	0.3	0.9	-0.1	-0.9	-0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.9	0.5	-1.1	0.1	-1.4
Wheeze or whistling in the chest in last year	0.4	0.7	0.9	-0.6	1.0	-0.8	1.0
Number of children fathered	0.7	0.8	2.2	-0.7	1.5	0.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	3.0	-1.6	0.1	-0.6	1.7
Age at first live birth	0.2	0.3	1.1	1.1	-0.1	0.2	-0.3
Pulse wave peak to peak time	1.6	1.9	2.8	1.5	-1.1	1.7	-1.0
Health satisfaction	0.6	0.7	1.5	-0.3	-0.9	1.2	-0.7
Shortness of breath walking on level ground	1.3	1.5	2.9	0.5	1.5	1.7	-1.0
Qualifications: College or University degree	0.1	0.3	0.6	-0.5	0.8	-0.3	-0.5
Eye problems/disorders: None of the above	0.6	0.7	1.9	-0.6	-0.7	-1.4	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.1	-1.0	-0.5	-0.8
Emphysema/chronic bronchitis	1.3	1.4	3.7	1.9	-0.2	1.2	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	-0.0	1.0	-0.3	-1.1
Neck or shoulder pain in last month	0.1	0.2	0.3	0.2	0.6	-0.3	-0.4
Medication: Blood pressure	1.3	2.3	3.6	-1.7	-0.0	-1.9	1.6
Angina (self-reported)	0.6	0.8	2.2	0.5	-0.5	1.5	-0.7
Migraine (self-reported)	0.5	0.6	2.0	-0.6	0.2	-0.4	-1.4
Medication: Ibuprofen	1.1	1.3	3.2	-0.8	-1.8	-1.1	0.1
Medication: Allopurinol	0.5	0.6	1.4	0.8	1.2	0.2	0.7
Medication: Omeprazole	1.1	1.4	4.9	-0.1	0.6	0.5	-2.2
Medication: Seretide 50 evohaler	0.4	0.4	0.8	0.8	0.9	0.3	-0.3
Mean time to correctly identify matches	0.2	0.5	0.9	1.0	0.7	0.5	0.4
Heart disease (mother)	0.2	0.2	0.5	-0.4	0.7	0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.1	-1.4	1.3	-1.1	1.1
Whole body fat mass	0.1	0.3	0.5	0.4	0.5	0.6	0.7
Leg fat mass (right)	0.1	0.4	1.6	-0.1	-0.0	0.3	1.3
Arm predicted mass (right)	0.3	1.4	3.3	-0.2	-0.9	1.8	1.3
Pulse rate, automated reading	0.1	0.2	0.3	0.6	0.1	0.5	0.4
Alcohol intake frequency.	1.4	3.3	7.3	1.2	-2.0	2.7	-0.7
Comparative height size at age 10	0.5	2.7	4.8	1.5	1.9	2.2	-0.5
Number of full sisters	0.4	0.4	1.1	0.3	-1.1	-0.1	0.7
Suffer from ‘nerves’	0.2	0.2	0.4	-0.6	0.5	-0.2	-0.5
Overall health rating	0.1	0.3	0.6	-0.6	0.8	-0.4	-0.2
Chest pain or discomfort	0.9	1.2	3.7	1.0	1.9	0.3	-0.3
Had major operations	0.2	0.3	0.5	0.1	-0.5	-0.6	0.7
Age at last live birth	1.6	2.3	4.4	1.5	-1.4	0.6	-2.1
Family relationship satisfaction	1.4	1.7	3.8	1.2	0.3	1.9	-1.2
Leg pain on walking	0.7	0.9	2.2	-0.4	-1.1	-0.1	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	7.3	-1.6	-2.7	-0.2	1.4
Commuting to job workplace: Car/motor vehicle	1.5	1.7	2.7	-0.8	-1.1	-1.6	1.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.4	-1.1	0.1	-1.0
Medication: Aspirin	0.8	1.1	2.4	0.3	1.4	0.1	1.5
Supplements: Vitamin C	0.8	1.0	2.1	-1.3	0.1	0.0	-1.5
Knee pain experienced in last month	1.0	1.5	3.1	0.4	1.8	1.7	-0.2
Hypertension (Self-reported)	1.4	4.0	6.1	-1.6	1.1	-2.4	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.9	-0.8	0.6	-0.4	1.4
Illnesses of father: Heart disease	1.5	2.1	4.9	0.1	-1.9	0.4	2.2
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-1.1	0.2	-0.9	0.3
Smoking status: Previous	0.1	0.1	0.2	0.2	0.5	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	5.4	-0.5	-0.9	2.3	-0.9
Whole body fat-free mass	0.3	1.9	4.4	-0.3	-1.0	2.1	1.5
Leg fat-free mass (right)	0.3	1.3	4.1	-0.2	-0.8	2.0	0.7
Arm fat percentage (left)	0.1	0.2	0.8	0.3	0.9	-0.2	0.1
Average weekly red wine intake	0.5	0.8	1.9	-0.8	1.4	-0.8	-0.3
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.7	-0.9	-0.9	-1.3	-0.6
Mood swings	0.2	0.4	1.6	0.3	1.3	-0.1	0.2
Loneliness, isolation	0.1	0.2	0.4	-0.3	0.5	0.6	-0.2
Long-standing illness, disability or infirmity	1.1	1.6	3.0	-1.7	0.8	-1.7	-0.1
Ever had bowel cancer screening	3.7	4.3	14.3	0.1	3.8	-0.2	-1.7
Diabetes diagnosed by doctor	0.7	1.2	2.2	-1.4	1.5	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.9	-0.1	-0.0	-0.1
Friendships satisfaction	1.2	1.5	2.5	1.2	-1.3	1.6	0.6
Qualifications: nursing, teaching	0.2	0.4	0.9	0.2	-0.7	0.4	-0.9
Commuting to job workplace: Walk	2.2	2.4	9.5	-0.1	-0.1	0.2	-3.1
Eye problems/disorders: Cataract	0.6	0.6	1.1	1.1	0.9	0.7	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.8	0.4	0.8	-1.7	0.3
Medication for cholesterol	0.2	0.3	0.4	0.7	-0.3	0.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.5	0.5	0.4	0.1
Back pain experienced in last month	1.1	1.6	3.5	-1.2	1.9	-1.0	-0.8
Mineral and other dietary supplements	0.4	0.6	1.4	0.6	-1.2	0.6	-0.0
Breast cancer (self-reported)	0.5	0.6	1.3	1.1	1.0	0.1	0.2
Asthma (self-reported)	0.0	0.0	0.0	-0.0	-0.1	0.2	-0.2
Osteoporosis (self-reported)	0.3	0.3	1.3	1.2	0.1	-0.2	-0.1
Osteoarthritis (self-reported)	1.4	1.8	3.6	0.9	0.6	1.9	-1.5
Medication: Aspirin	0.9	1.2	3.0	0.3	1.7	-0.1	1.2
Medication: Gliclazide	0.3	0.3	1.1	-1.1	-0.4	-0.2	0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	0.3	0.2	-0.1	-1.2
Smoking status: Current	1.2	2.0	4.5	1.7	-0.4	2.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.3	-1.8	0.1	-1.2	1.0
Whole body water mass	0.3	1.9	3.9	-0.3	-0.9	2.0	1.7
Leg predicted mass (right)	0.2	1.3	3.9	-0.3	-0.8	2.0	0.9
Arm fat mass (left)	0.0	0.2	0.4	0.3	0.3	0.3	0.6
Number of self-reported non-cancer illnesses	0.7	1.2	2.8	-1.2	1.7	-0.6	-0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.5	-0.6	0.7	-0.7
Miserableness	0.5	0.8	1.7	-1.3	0.6	-1.0	0.5
Guilty feelings	0.3	0.4	1.0	-0.2	-1.0	-0.1	0.8
Wears glasses or contact lenses	0.4	0.4	1.3	0.1	1.1	0.4	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.6	-0.3	-0.1
Hearing aid user	0.9	1.0	2.9	-0.6	0.5	-1.7	0.7
Mother’s age at death	0.6	0.7	2.5	1.6	0.3	-0.2	-0.6
Financial situation satisfaction	1.7	2.1	5.2	0.8	-1.5	2.3	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.3	-0.4	-0.7	-0.3
Commuting to job workplace: Public transport	0.7	0.8	1.6	-1.3	-0.4	0.3	1.2
Eye problems/disorders: Glaucoma	1.9	2.2	4.1	-1.4	-1.3	-0.9	2.0
Medication: Blood pressure	0.7	1.3	2.4	-0.3	0.9	-1.6	1.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	0.8	0.2	0.6	-0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.5	-1.2	0.7	-1.2	0.7
High cholesterol (Self-reported)	1.6	2.8	6.0	-2.1	-0.2	-2.5	0.8
Medication: Bendroflumethiazide	0.4	0.6	1.4	-1.2	0.2	-1.1	0.1
Medication: Paracetamol	0.9	1.3	3.8	-0.1	-1.2	-0.2	2.0
Medication: Lisinopril	1.5	1.9	3.6	-1.4	-1.0	-1.1	1.9
Medication: Atorvastatin	1.3	1.6	2.4	-1.0	1.0	-1.5	1.4
Illnesses of father: High blood pressure	0.7	0.9	1.7	0.8	-0.8	0.8	1.3
Alcohol drinker status: Never	1.2	1.4	4.5	-1.0	-2.1	-0.3	0.1
Ever smoked	1.6	2.8	6.1	2.0	-0.5	2.5	-0.9
Basal metabolic rate	0.3	1.7	3.8	-0.2	-0.9	1.9	1.4
Leg fat percentage (left)	0.1	0.3	0.6	0.3	-0.4	-0.6	0.8
Arm fat-free mass (left)	0.4	1.9	4.1	-0.3	-1.2	1.5	2.0
Number of operations (self-reported)	0.6	0.8	1.6	-0.7	1.1	0.3	1.3
Average weekly beer plus cider intake	0.6	0.9	2.3	-1.1	-1.5	0.1	0.5
Irritability	0.3	0.5	1.2	0.6	-0.3	1.1	-0.5
Risk taking	0.3	0.4	0.9	-0.5	-0.1	0.6	-1.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.0	0.4	0.2	0.2
Fractured/broken bones in last 5 years	1.5	1.9	4.5	-1.5	-0.6	0.7	2.1
Age started oral contraceptive pill	2.2	2.7	9.2	-0.0	3.0	-1.2	-0.6
Diastolic blood pressure, automated reading	0.6	1.8	6.1	-0.5	0.2	-0.9	2.5
Ever depressed for a whole week	0.6	0.8	1.8	-1.3	-0.5	-0.9	0.4
Unable to work because of sickness or disability	1.3	1.7	5.0	-2.2	-0.3	-0.1	1.2
Commuting to job workplace: Cycle	0.7	0.9	1.8	0.2	-0.7	1.3	1.1
Myopia	0.1	0.2	0.5	-0.7	0.2	-0.3	0.2
Vascular/heart problems diagnosed by doctor	1.1	2.9	4.6	1.5	-1.3	1.8	-2.1
Cholesterol lowering medication	0.7	1.1	2.1	-1.5	0.4	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.6	-0.7	0.6	0.2	-1.6
Pain experienced in last month	0.2	0.3	0.6	0.5	-0.6	-0.2	0.8
Supplements: Calcium	0.4	0.4	0.8	0.9	0.8	0.1	-0.6
Basal cell carcinoma (self-reported)	1.0	1.2	2.2	-1.2	0.2	-1.5	1.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.3	0.2	-0.0	1.5	0.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.1	2.0	1.6	1.5	-0.9
Heart disease (siblings)	0.3	0.4	1.2	-0.7	1.1	0.0	-0.0
Alcohol drinker status: Previous	1.6	1.8	3.0	0.5	1.2	1.7	-1.6
Pack years of smoking	0.2	0.3	0.6	0.2	-0.6	-0.3	0.8
Impedance of whole body	0.4	1.9	4.3	2.1	1.1	0.1	-1.4
Leg fat mass (left)	0.1	0.4	1.1	0.2	-0.4	0.5	1.0
Arm predicted mass (left)	0.4	2.2	4.0	-0.2	-1.5	1.6	2.0