Hub : Genes

SMG9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.331	0.0500	1.5e-13	0.257	NA	0.281	NA	0.286	2.7e-19	NA	2.7e-21	NA	1.2e-21
2	GTEx	Esophagus Muscularis	0.149	0.0520	4.2e-04	0.005	NA	0.051	NA	0.034	1.6e-01	NA	4.6e-04	NA	3.8e-03
3	GTEx	Lung	0.178	0.0463	1.3e-05	0.072	NA	0.029	NA	0.047	3.7e-06	NA	2.7e-03	NA	1.6e-04
4	GTEx	Muscle Skeletal	0.134	0.0371	4.5e-05	0.096	NA	0.096	NA	0.094	1.0e-09	NA	1.1e-09	NA	1.6e-09
5	GTEx	Nerve Tibial	0.139	0.0453	4.8e-04	0.026	NA	0.053	NA	0.082	5.9e-03	NA	1.2e-04	NA	2.0e-06
6	GTEx	Testis	0.341	0.0690	3.9e-06	0.258	NA	0.264	NA	0.263	7.5e-12	NA	4.0e-12	NA	4.6e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.8	-0.5	-0.2	-0.3	-0.6	-1.4	0.6
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.3	0.0	0.2	0.3	-0.1	-0.2
Depressed Affect (Nagel 2018)	0.6	1.3	5.5	-0.3	-0.8	-1.1	-0.3	-2.3	0.4
Depression (Nagel 2018)	0.7	1.1	4.6	-0.2	0.1	-1.4	-0.1	-2.1	0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.2	-0.4	-0.0	-1.2	-0.4	-2.0	0.3
Neuroticism (Nagel 2018)	0.2	0.5	2.7	0.2	-0.5	-0.3	0.1	-1.6	-0.1
Schizophrenia (2018)	0.2	0.5	0.7	0.8	0.5	0.5	0.8	0.8	-0.8
Schizophrenia vs Biploar Disorder	2.1	2.7	3.9	1.7	1.7	1.2	1.6	2.0	-1.6
Worry (Nagel 2018)	0.0	0.1	0.2	0.2	-0.2	0.5	0.3	-0.4	-0.2
Alzheimer’s Disease (in mother)	0.4	0.4	1.3	0.5	1.1	0.3	0.6	0.3	-0.7
Alzheimer’s Disease (in father)	0.7	0.7	1.3	-1.1	-0.2	-0.8	-0.9	-0.8	1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-0.5	1.3	0.0	-0.3	0.3	0.4
Crohns Disease (2017)	0.4	0.8	1.3	1.1	1.1	0.6	0.9	0.7	-0.9
Irritable Bowel Disease (IBD)	1.3	3.0	7.1	1.6	1.1	1.9	1.3	2.7	-1.3
Ulcerative Colitis (UC)	1.1	2.1	7.8	1.0	0.1	1.6	0.8	2.8	-0.7
Major Depression (MDD)	1.2	1.5	3.0	1.1	1.7	1.1	1.3	0.4	-1.3
Reaction Time	0.3	0.6	3.2	0.1	-1.8	-0.1	-0.0	-0.4	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.3	0.5	1.5	0.3	0.5	-0.6	-0.6
Breast Cancer	2.1	5.2	25.6	0.8	5.1	1.3	1.0	1.0	-1.1
Ovarian Cancer	0.2	0.3	0.5	-0.4	0.5	-0.6	-0.4	-0.7	0.4
Prostate Cancer	1.0	1.4	1.8	1.3	0.7	1.3	1.2	1.2	-1.3
Age at First Birth	1.7	2.5	5.5	-1.5	-1.0	-2.3	-1.3	-1.8	1.3
Bipolar Disorder (2011)	0.7	0.7	1.5	0.8	0.4	1.2	0.9	0.2	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.6	-0.1	-1.0	-0.7	-0.6	0.6
Coronary Artery Disease (CAD)	5.9	7.0	9.5	3.1	0.9	2.5	2.9	3.1	-2.8
Crohns Disease (2012)	0.3	0.5	1.2	-0.5	0.1	-0.8	-0.6	-1.1	0.5
Mean Putamen Volume	1.1	1.2	1.9	1.1	0.3	1.4	1.1	1.3	-1.2
Fasting Glucose	0.2	0.2	1.0	-0.1	1.0	0.2	-0.1	-0.5	-0.1
HbA1C	0.2	0.2	0.8	-0.1	0.9	-0.6	-0.4	0.3	0.3
HDL Cholesterol	0.1	0.1	0.2	0.2	-0.5	-0.1	0.3	0.2	-0.3
LDL Cholesterol	0.7	1.2	2.5	-1.1	0.6	-1.6	-1.1	-0.6	1.1
Lupus	0.3	0.4	1.0	-0.5	1.0	-0.3	-0.4	-1.0	0.4
Neuroticism (2016)	0.1	0.1	0.3	0.2	-0.5	0.3	0.2	-0.6	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.9	-0.2	0.0	-0.8	-0.1	-1.4	0.1
Rheumatoid Arthritis	4.5	6.2	9.0	-3.0	-1.4	-2.4	-2.9	-2.0	2.9
Schizophrenia (2014)	0.1	0.2	0.5	0.5	0.4	0.4	0.6	0.2	-0.7
Triglycerides	0.1	0.2	0.4	-0.0	0.5	-0.4	-0.3	-0.6	0.3
Type 2 Diabetes (T2D) (2012)	2.4	2.8	3.8	1.9	1.3	1.5	2.0	1.3	-1.9
Ulcerative Colitis	2.2	3.2	9.1	1.2	0.9	2.3	1.2	3.0	-1.2
Blood Eosinophil Count	0.1	0.4	1.8	0.4	1.3	0.4	0.3	0.6	-0.2
Blood Platelet Count	0.9	11.0	12.7	3.6	3.0	3.3	3.5	3.1	-3.5
Blood Red Count	7.3	70.7	88.7	9.4	5.5	8.2	9.4	7.8	-9.4
Blood White Count	2.5	18.5	30.6	5.1	4.0	3.0	5.4	0.2	-5.5
Heel T-Score	0.3	2.6	6.8	-0.7	2.5	1.3	-0.5	2.6	0.5
BMI	0.1	0.6	1.0	1.0	0.8	-0.0	0.7	0.9	-0.8
Height	1.4	26.1	59.8	-4.5	-0.8	-6.3	-4.3	-7.7	4.2
Waist Hip Ratio (WHR)	1.4	6.5	12.2	2.3	3.5	2.2	2.4	2.3	-2.3
Systolic Blood Pressure	0.0	0.2	0.3	0.4	0.2	0.5	0.3	0.5	-0.3
Smoking Status	0.4	0.8	1.9	0.7	0.0	1.1	0.9	1.4	-0.8
Allergy or Eczema	0.6	1.7	6.8	-0.4	0.7	-1.4	-0.6	-2.6	0.7
Cardiovascular Disease	2.3	7.6	9.1	3.0	2.7	2.6	3.0	2.2	-3.0
Hypothyroidism (self reported)	0.9	2.0	3.0	1.5	1.7	1.4	1.5	0.9	-1.4
Respiratory disease	0.1	0.1	0.3	0.1	0.4	-0.6	-0.0	-0.6	0.0
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	0.9	0.1	0.5	0.7	0.2	-0.7
Lung FEV1/FVC ratio	0.1	0.7	1.1	0.8	1.0	0.5	1.1	0.3	-1.1
Lung FVC	0.2	0.9	1.4	-1.2	-1.0	-0.2	-1.2	0.2	1.2
Neuroticism	0.1	0.2	0.6	0.1	-0.5	-0.4	0.2	-0.8	-0.2
Chronotype (morning person)	2.0	4.5	10.8	-2.0	-3.3	-1.7	-2.0	-1.1	2.0
Hair Pigment	0.1	4.3	13.7	-1.5	-3.7	-1.4	-1.4	-1.8	1.5
Tanning	0.0	0.5	1.2	-0.4	0.6	-0.5	-0.7	-1.1	0.6
Hand grip strength (left)	0.2	0.6	2.3	0.6	1.5	0.4	0.6	-0.5	-0.6
Number of treatments/medications taken	0.4	0.8	3.6	0.6	1.9	0.4	0.6	0.1	-0.5
Average weekly spirits intake	0.3	0.4	0.5	-0.7	0.0	-0.6	-0.6	-0.7	0.7
Sensitivity / hurt feelings	0.2	0.4	0.6	0.6	-0.7	0.5	0.5	0.8	-0.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.3	0.4	0.9	-1.3	0.3	-1.8	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	1.7	1.0	1.3	0.7	0.9	0.3	-0.9
Relative age of first facial hair	0.2	0.4	0.7	0.5	0.5	0.6	0.7	0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.0	1.4	0.3	1.3	1.3	1.3	-1.3
Ever used hormone-replacement therapy (HRT)	1.6	2.1	6.1	-1.3	0.1	-1.4	-1.1	-2.5	1.2
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.6	0.4	-0.0	-0.5	0.2	0.4
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.2	-0.4	-0.2	-0.4	-0.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	0.9	-0.4	-0.1	0.8	0.1	-0.8
Angina	3.4	4.5	5.8	2.2	0.3	2.3	2.4	2.4	-2.3
Medication for hormone replacement therapy	2.2	2.4	3.2	1.5	1.0	1.5	1.7	1.7	-1.8
Vitamin and mineral supplements	0.6	0.8	1.3	-1.1	-0.9	-0.6	-1.2	-0.2	1.1
Supplements: Zinc	0.7	0.7	1.2	-0.7	0.0	-1.1	-0.9	-0.9	1.0
Medication: Co-codamol	0.2	0.3	1.4	0.1	0.2	0.1	-0.0	-1.2	-0.0
Medication: Metformin	0.6	0.9	1.5	1.2	0.3	0.8	1.2	0.6	-1.2
Diabetes (father)	0.2	0.2	1.3	-0.1	-1.1	0.1	-0.2	-0.0	0.2
Diabetes (mother)	0.3	0.4	0.7	0.8	0.5	0.1	0.9	0.2	-0.8
Severe depression (siblings)	0.6	0.6	0.9	1.0	0.5	0.7	0.9	0.6	-0.9
Pack years adult smoking proportion	0.1	0.2	0.9	0.3	1.0	0.3	0.3	-0.1	-0.2
Impedance of leg (right)	0.3	1.3	3.0	0.8	-0.3	1.7	1.0	1.4	-0.9
Leg fat-free mass (left)	0.4	2.0	4.7	-0.8	0.9	-2.2	-0.8	-2.1	0.8
Trunk fat percentage	0.0	0.1	0.2	-0.4	-0.1	-0.4	-0.4	0.4	0.3
Hand grip strength (right)	0.6	1.7	3.6	1.5	1.9	0.7	1.4	0.2	-1.4
Townsend deprivation index at recruitment	1.4	1.9	2.9	1.7	-0.1	1.5	1.5	1.4	-1.4
Current tobacco smoking	0.1	0.2	0.4	0.2	-0.6	0.3	0.5	-0.2	-0.4
Average weekly fortified wine intake	0.2	0.2	1.1	-0.1	1.0	0.1	0.0	-0.1	0.1
Maternal smoking around birth	0.2	0.3	1.3	0.3	1.1	-0.3	0.4	0.1	-0.3
Fed-up feelings	0.4	0.7	2.7	-0.2	0.0	-1.1	-0.2	-1.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.5	0.2	0.1	-1.0	0.2	-1.2	-0.3
Relative age voice broke	1.0	1.6	2.3	1.2	0.8	1.5	1.4	1.1	-1.5
Taking other prescription medications	0.1	0.2	1.1	0.2	1.0	0.0	0.1	0.1	-0.1
Age when periods started (menarche)	3.0	7.2	8.5	2.9	2.3	2.8	2.8	2.4	-2.8
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	3.7	-1.9	-1.5	-1.5	-1.8	-1.0	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	4.4	0.2	2.1	0.8	0.3	1.1	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.3	0.4	0.7	0.4	0.3	-0.4
Qualifications: CSEs or equivalent	0.8	1.1	3.0	0.8	0.5	1.2	0.8	1.7	-0.8
Serious illness, injury or assault to yourself	0.6	0.8	1.2	-0.8	-0.5	-1.1	-0.8	-1.1	0.7
High blood pressure	0.2	0.4	0.8	0.8	0.9	0.2	0.7	-0.1	-0.8
Hayfever, allergic rhinitis or eczema	0.9	1.9	6.6	-0.7	0.9	-1.3	-0.9	-2.6	0.9
Multivitamins +/- minerals	2.0	2.5	4.2	2.0	1.0	1.1	2.1	1.0	-2.0
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.6	0.9	0.2	0.7	-0.5	-0.7
Supplements: Glucosamine	0.5	0.7	1.3	-1.0	-0.1	-0.4	-1.1	-0.8	1.1
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.8	1.2	1.0	0.9	1.3	0.9	-1.3
Medication: Atenolol	6.5	8.1	12.4	3.5	1.4	2.8	3.4	1.8	-3.4
Medication: Levothyroxine sodium	2.5	4.3	6.8	1.8	2.6	2.4	1.8	1.9	-1.7
Sitting height	0.2	1.7	3.3	-0.9	1.7	-1.6	-0.7	-1.8	0.7
Chronic bronchitis/emphysema (father)	0.9	1.0	1.4	1.2	1.2	0.5	1.1	0.6	-1.2
High blood pressure (mother)	0.1	0.1	0.5	0.2	-0.7	-0.2	0.1	0.0	0.0
Body mass index (BMI)	0.1	0.3	0.7	0.5	0.8	-0.1	0.2	0.7	-0.3
Impedance of leg (left)	0.1	0.7	1.7	0.3	-0.5	1.3	0.5	1.3	-0.5
Leg predicted mass (left)	0.4	1.9	4.5	-0.7	0.9	-2.1	-0.8	-2.1	0.7
Trunk fat mass	0.1	0.3	0.8	-0.5	0.3	-0.9	-0.5	-0.1	0.4
Waist circumference	0.1	0.3	1.6	0.2	1.2	-0.2	0.1	0.5	-0.1
Number of incorrect matches in round	0.8	1.4	2.7	-1.0	-1.1	-1.2	-0.9	-1.6	1.0
Past tobacco smoking	0.8	1.4	4.1	-1.0	-0.2	-1.3	-0.9	-2.0	0.9
Alcohol usually taken with meals	0.1	0.2	1.1	0.0	1.0	0.2	0.1	0.1	-0.2
Nervous feelings	0.3	0.5	1.1	-0.5	-1.0	-0.3	-0.7	-0.7	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.9	0.3	0.1	-0.3	0.5	-0.9	-0.5
Hearing difficulty/problems with background noise	0.3	0.6	2.5	0.5	1.6	0.2	0.5	-0.1	-0.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.7	0.1	-0.5	0.2	-0.1	0.9	-0.0
Had menopause	2.3	2.9	3.5	-1.8	-1.7	-1.9	-1.6	-1.5	1.7
Had other major operations	0.9	1.1	1.8	1.3	0.2	0.9	1.3	0.7	-1.3
Forced vital capacity (FVC)	0.4	1.7	3.1	-1.0	-1.5	-1.3	-1.0	-1.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	2.3	-0.3	1.5	0.2	-0.2	0.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	0.7	0.3	0.8	0.7	0.6	-0.7
Qualifications: None of the above	0.4	0.8	3.5	-0.3	-1.9	-0.2	-0.3	-1.0	0.4
Financial difficulties in last 2 years	0.9	1.3	2.5	1.1	1.6	-0.1	0.9	-1.6	-0.8
Mouth/teeth dental problems	1.0	1.6	6.0	0.9	2.5	1.2	0.8	0.3	-0.7
Heart attack	0.1	0.2	0.4	-0.2	-0.4	-0.6	-0.1	-0.5	0.3
Allergy	0.7	1.6	3.9	1.0	-0.7	1.2	1.3	2.0	-1.2
Pain all over the body in last month	0.7	0.7	1.0	-1.0	-0.9	-0.7	-1.0	-0.3	0.9
Diabetes (self-reported)	0.2	0.3	0.9	0.6	0.9	-0.1	0.4	-0.4	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	-0.4	1.4	-0.1	-0.6	-0.5	0.7
Medication: Ramipril	0.2	0.3	0.6	0.8	0.8	0.2	0.4	0.1	-0.4
Medication: Simvastatin	0.4	0.6	1.4	0.6	1.2	0.4	0.9	0.7	-0.9
Fluid intelligence score	0.1	0.1	0.5	-0.2	0.5	-0.2	-0.2	-0.7	0.1
Illnesses of siblings	1.4	2.0	2.9	-1.4	-0.2	-1.4	-1.7	-1.6	1.7
Neuroticism score	0.4	0.9	2.5	-0.6	-0.5	-1.1	-0.7	-1.6	0.7
Weight	0.2	0.9	2.3	-0.6	0.9	-1.5	-0.7	-1.1	0.6
Impedance of arm (right)	0.2	0.7	1.5	-1.2	-1.0	0.2	-0.9	0.4	0.9
Arm fat percentage (right)	0.1	0.2	0.4	-0.5	0.0	-0.3	-0.6	0.6	0.5
Trunk fat-free mass	0.5	2.8	6.8	-0.8	1.0	-2.5	-1.0	-2.6	1.0
Hip circumference	0.3	1.1	2.5	-1.0	-0.2	-1.6	-1.2	-0.7	1.1
Time employed in main current job	0.5	0.6	2.8	0.4	1.7	-0.2	0.6	0.0	-0.5
Alcohol intake versus 10 years previously	0.5	0.8	1.4	1.0	-0.1	1.2	0.9	0.7	-0.9
Father’s age at death	4.4	5.9	10.0	-2.4	-1.9	-2.4	-2.2	-3.2	2.3
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.5	-0.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.9	1.0	1.7	0.6	1.0	0.8	-1.0
Falls in the last year	0.2	0.3	1.6	-0.1	1.3	-0.4	0.0	-0.4	-0.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.2	-0.3	-0.4	0.2	-0.4	-0.1
Number of live births	0.2	0.3	0.9	-0.3	-0.9	-0.5	-0.3	0.8	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.2	-0.3	-0.9	-0.8	-0.2	-1.1	0.2
Pulse rate	0.6	1.0	1.7	-1.2	-0.7	-0.6	-1.3	-0.2	1.3
Happiness	0.4	0.4	1.9	0.5	0.3	-0.1	0.5	-1.4	-0.4
Noisy workplace	0.4	0.5	1.8	-0.6	-1.3	0.3	-0.6	-0.1	0.6
Qualifications: A levels/AS levels or equivalent	2.2	4.8	6.5	1.8	2.6	2.6	1.9	2.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	4.3	4.9	7.0	2.2	2.6	2.2	1.8	2.6	-1.6
Mouth/teeth dental problems: Dentures	1.0	1.7	7.6	-0.6	-2.8	-0.9	-0.7	-0.8	0.6
Asthma	0.4	0.7	3.3	-0.2	1.8	-0.3	-0.5	-0.8	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	-0.7	0.4	-0.7	-0.7	-0.5	0.7
Medication: Cholesterol lowering	3.3	5.1	5.8	2.4	1.8	2.1	2.4	2.4	-2.4
Depression (self-reported)	0.4	0.5	2.1	-0.1	0.2	-0.9	0.0	-1.5	-0.0
Medication: Lansoprazole	1.5	1.7	3.0	-1.1	-0.4	-1.7	-1.3	-1.4	1.4
Prospective memory result	0.3	0.3	0.8	0.5	0.9	0.0	0.5	-0.5	-0.5
Lung cancer (father)	0.5	0.6	0.8	-0.9	-0.7	-0.8	-0.8	-0.7	0.7
Illnesses of mother	0.2	0.2	0.4	-0.3	-0.5	-0.1	-0.6	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.5	-0.9	-0.2	-1.0	-0.9	-1.6	0.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.4	-0.5	0.4
Impedance of arm (left)	0.1	0.7	1.5	-1.2	-0.9	0.2	-0.9	0.3	0.9
Arm fat mass (right)	0.1	0.4	0.9	-0.7	0.3	-0.9	-0.8	-0.1	0.7
Trunk predicted mass	0.5	2.8	6.9	-0.9	0.9	-2.5	-1.0	-2.6	1.0
Standing height	0.7	6.9	17.3	-2.3	0.3	-3.3	-2.0	-4.2	2.0
Length of working week for main job	0.4	0.5	0.9	0.9	0.4	0.5	0.9	-0.0	-0.9
Exposure to tobacco smoke at home	1.3	1.5	7.5	-0.6	-2.7	-0.2	-0.6	-0.6	0.6
Breastfed as a baby	2.5	3.1	4.9	-1.8	1.5	-1.4	-1.8	-2.2	1.8
Tense / ‘highly strung’	0.1	0.2	1.0	0.2	-0.1	-0.1	0.4	-1.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.3	0.1	0.2	-0.7	-0.1	-1.1	0.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.4	0.2	0.4	0.2	-0.0	-0.6	0.1
Birth weight of first child	0.4	0.7	2.2	0.1	1.5	-0.5	-0.0	-1.3	-0.1
Peak expiratory flow (PEF)	0.2	0.4	1.5	0.1	-1.2	-0.4	0.3	-0.7	-0.4
Pulse wave reflection index	0.3	0.3	1.1	-0.1	0.7	-0.3	-0.2	-1.1	0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	1.1	0.2	0.7	1.0	0.1	-0.9
Loud music exposure frequency	0.9	1.0	2.3	0.8	1.5	0.9	0.8	1.0	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.3	0.5	1.2	0.9	0.4	1.5	-0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	0.3	-1.2	-0.1	0.5	1.0	-0.6
Blood clot in the leg (DVT)	1.1	1.4	3.6	-1.0	-0.9	-1.0	-0.9	-1.9	0.9
Medication: Paracetamol	0.2	0.4	1.3	-0.1	-0.5	-0.8	-0.1	-1.1	0.2
Headache pain in last month	1.0	1.7	3.2	-1.3	-1.8	-1.2	-1.2	-1.2	1.2
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	4.7	-2.1	-1.7	-1.6	-2.1	-1.5	2.2
Glaucoma (self-reported)	0.4	0.5	2.9	-0.2	1.7	-0.0	-0.2	-0.1	0.1
Gout (self-reported)	0.6	0.8	2.2	0.5	0.9	1.2	0.5	1.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.8	1.0	1.3	0.9	1.1	0.2	-1.0
Medication: Amlodipine	0.3	0.4	0.7	0.8	0.7	0.1	0.7	-0.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.0	0.4	-0.1	-0.3	-0.3	0.3
Birth weight	0.1	0.2	0.4	0.6	-0.1	-0.2	0.5	-0.7	-0.6
Chronic bronchitis/emphysema (mother)	3.9	4.5	6.5	2.4	0.4	1.9	2.5	2.2	-2.5
High blood pressure (siblings)	0.6	0.9	1.4	1.0	0.3	0.8	1.2	0.8	-1.2
Forced vital capacity (FVC), Best measure	0.9	3.3	5.4	-1.9	-1.2	-1.8	-1.8	-2.3	1.8
Body fat percentage	0.0	0.1	0.3	-0.2	-0.0	-0.2	-0.2	0.6	0.1
Leg fat percentage (right)	0.1	0.2	0.9	0.3	0.3	0.3	0.1	1.0	-0.2
Arm fat-free mass (right)	0.3	1.3	3.7	-0.1	0.9	-1.9	-0.3	-1.9	0.3
Exposure to tobacco smoke outside home	0.4	0.5	1.0	0.8	-0.6	0.7	1.0	-0.1	-0.9
Comparative body size at age 10	0.3	0.9	1.3	-1.0	-0.3	-0.9	-1.1	-0.8	1.1
Number of full brothers	0.2	0.2	0.8	0.4	-0.4	0.1	0.3	0.9	-0.4
Worry too long after embarrassment	0.6	1.0	1.8	-0.8	-0.1	-1.3	-1.1	-1.3	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.6	-0.8	0.3	-0.7	-0.8	-0.7	0.7
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.2	0.4	-0.5	-0.2	-0.4	0.1
Number of children fathered	0.3	0.3	0.7	0.7	0.2	0.3	0.8	0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.7	0.7	1.6	-0.1	0.8	0.5	-0.8
Age at first live birth	0.9	1.5	2.5	-1.5	0.3	-0.9	-1.5	-1.2	1.6
Pulse wave peak to peak time	0.1	0.1	0.2	0.3	-0.2	-0.1	0.4	0.3	-0.4
Health satisfaction	0.8	1.0	1.7	1.3	1.0	0.9	1.1	0.2	-1.2
Shortness of breath walking on level ground	0.5	0.5	0.7	-0.5	-0.6	-0.9	-0.7	-0.8	0.8
Qualifications: College or University degree	1.6	5.0	10.1	1.8	3.2	2.0	2.1	1.7	-2.1
Eye problems/disorders: None of the above	0.4	0.4	1.3	0.6	1.1	0.4	0.6	0.3	-0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	0.6	1.0	0.4	0.8	0.2	-0.8
Emphysema/chronic bronchitis	1.4	1.6	3.5	1.2	-0.6	1.1	1.2	1.9	-1.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	-0.5	-0.8	-0.1	-0.4	0.3	0.3
Neck or shoulder pain in last month	0.0	0.0	0.1	0.2	-0.3	-0.1	0.2	0.3	-0.1
Medication: Blood pressure	0.6	1.1	1.9	1.4	1.0	0.6	1.3	0.3	-1.4
Angina (self-reported)	3.3	4.4	6.3	2.1	-0.1	2.4	2.2	2.5	-2.2
Migraine (self-reported)	0.9	1.1	1.9	-1.4	-0.8	-0.8	-1.3	-0.4	1.4
Medication: Ibuprofen	0.3	0.4	0.6	-0.8	-0.1	-0.6	-0.7	-0.5	0.7
Medication: Allopurinol	0.1	0.1	0.1	0.3	0.4	0.3	0.3	0.3	-0.2
Medication: Omeprazole	1.9	2.2	5.0	1.4	2.2	1.1	1.5	0.8	-1.5
Medication: Seretide 50 evohaler	3.9	4.5	6.7	-2.6	-1.1	-1.8	-2.5	-1.8	2.5
Mean time to correctly identify matches	0.6	1.1	3.8	-0.7	-2.0	-0.6	-0.7	-0.8	0.7
Heart disease (mother)	0.1	0.2	0.4	-0.4	0.0	-0.6	-0.2	-0.6	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.6	0.8	0.0	0.8	0.9	-0.8
Whole body fat mass	0.0	0.1	0.5	-0.3	0.2	-0.7	-0.4	0.1	0.3
Leg fat mass (right)	0.0	0.1	0.3	0.0	0.6	-0.4	-0.1	0.2	0.0
Arm predicted mass (right)	0.4	1.9	5.3	-0.4	0.4	-2.2	-0.6	-2.3	0.5
Pulse rate, automated reading	0.5	1.5	3.2	0.9	0.7	1.4	1.0	1.8	-1.0
Alcohol intake frequency.	1.6	3.7	8.8	-1.8	-3.0	-1.9	-1.7	-0.7	1.8
Comparative height size at age 10	0.9	5.1	12.1	-2.0	-0.7	-2.9	-1.8	-3.5	1.8
Number of full sisters	0.2	0.3	1.5	-0.0	1.2	0.2	-0.1	0.5	0.0
Suffer from ‘nerves’	0.6	0.9	2.7	-1.0	0.1	-0.4	-0.9	-1.6	0.9
Overall health rating	0.0	0.1	0.1	0.2	0.1	-0.3	0.2	-0.3	-0.2
Chest pain or discomfort	0.1	0.2	0.3	0.4	0.1	-0.0	0.4	0.6	-0.5
Had major operations	0.4	0.5	0.8	-0.9	-0.1	-0.6	-0.9	-0.2	0.9
Age at last live birth	0.6	0.8	1.2	-1.1	0.2	-0.9	-1.1	-0.8	1.1
Family relationship satisfaction	1.4	1.8	3.4	-0.8	-1.5	-1.5	-1.0	-1.8	1.0
Leg pain on walking	1.2	1.5	2.6	1.4	0.9	1.0	1.5	0.7	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.4	0.1	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	0.2	1.2	-0.0	0.3	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.7	-0.8	-1.6	-0.2	-0.8	0.4	0.8
Medication: Aspirin	0.4	0.6	0.7	0.7	0.9	0.8	0.7	0.8	-0.7
Supplements: Vitamin C	0.5	0.6	1.4	-1.2	-0.3	-0.7	-0.9	-0.4	0.9
Knee pain experienced in last month	1.5	2.4	3.5	-1.4	-1.9	-1.8	-1.3	-1.6	1.2
Hypertension (Self-reported)	0.3	0.9	1.5	1.1	1.2	0.6	1.0	0.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	0.7	1.0	-0.8	0.5	-0.4	-0.5
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.8	-0.9	-0.6	-0.8	0.1	0.8
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.9	-0.4	-0.9	-0.8	-0.3	0.8
Smoking status: Previous	1.1	1.6	3.5	1.3	0.8	1.1	1.1	1.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	6.4	-1.1	-0.6	-1.4	-1.1	-2.5	1.1
Whole body fat-free mass	0.4	2.5	6.0	-0.8	1.0	-2.4	-0.9	-2.4	0.8
Leg fat-free mass (right)	0.4	2.3	5.3	-1.0	0.8	-2.3	-1.0	-2.3	0.9
Arm fat percentage (left)	0.0	0.2	0.5	-0.4	-0.0	-0.2	-0.5	0.7	0.3
Average weekly red wine intake	1.0	1.4	3.6	0.6	1.9	1.3	0.9	1.3	-0.9
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.7	-1.3	-0.9	-0.9	-1.2	-1.1	1.3
Mood swings	0.9	1.6	3.6	-1.1	-0.9	-1.4	-1.1	-1.9	1.1
Loneliness, isolation	0.4	0.5	1.8	0.1	-0.8	-0.8	0.1	-1.3	-0.1
Long-standing illness, disability or infirmity	1.4	2.1	2.6	1.6	1.2	1.5	1.5	1.4	-1.6
Ever had bowel cancer screening	0.2	0.2	1.0	0.2	-0.4	-0.2	0.2	-1.0	-0.2
Diabetes diagnosed by doctor	0.2	0.4	0.7	0.8	0.9	0.1	0.6	-0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.2	0.0	-0.0	0.2	-0.0	-0.2
Friendships satisfaction	0.9	1.1	2.7	-0.8	-1.7	-0.7	-1.0	-0.7	1.0
Qualifications: nursing, teaching	0.6	0.9	2.2	-0.9	1.5	-0.9	-0.8	-0.6	0.8
Commuting to job workplace: Walk	0.1	0.1	0.3	0.1	-0.6	0.3	-0.2	0.4	0.1
Eye problems/disorders: Cataract	1.3	1.5	3.6	-1.1	-1.9	-1.0	-1.1	-0.7	1.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.1	-1.8	-1.3	-0.9	-2.0	-0.5	1.9
Medication for cholesterol	0.6	0.9	1.9	-0.5	-1.4	-1.0	-0.8	-0.9	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	0.0	0.6	0.4	0.2	0.1	-0.2
Back pain experienced in last month	0.2	0.3	0.4	0.6	0.6	0.4	0.5	0.6	-0.6
Mineral and other dietary supplements	0.9	1.2	1.7	-1.1	-1.3	-1.2	-1.1	-0.6	1.1
Breast cancer (self-reported)	0.7	0.9	2.4	-0.7	-1.6	-0.8	-0.8	-0.4	0.8
Asthma (self-reported)	0.4	0.8	2.2	-0.4	1.5	-0.6	-0.7	-1.0	0.6
Osteoporosis (self-reported)	0.2	0.2	0.6	0.5	0.5	0.7	0.3	-0.2	-0.4
Osteoarthritis (self-reported)	1.3	1.7	4.7	1.0	0.0	1.2	1.1	2.2	-1.2
Medication: Aspirin	1.1	1.4	1.9	1.2	0.9	1.2	1.2	1.4	-1.2
Medication: Gliclazide	0.4	0.4	0.8	0.7	-0.3	0.7	0.6	0.9	-0.6
Illnesses of father: None of the above (group 1)	0.5	0.6	2.2	0.5	1.5	0.7	0.6	0.3	-0.5
Smoking status: Current	0.2	0.3	0.6	0.3	-0.8	0.6	0.6	0.3	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-0.6	-0.6	-1.0	-0.5	-1.4	0.5
Whole body water mass	0.4	2.5	6.2	-0.8	1.0	-2.4	-0.9	-2.5	0.8
Leg predicted mass (right)	0.4	2.4	5.6	-1.0	0.8	-2.4	-1.0	-2.3	1.0
Arm fat mass (left)	0.1	0.4	0.9	-0.6	0.4	-0.9	-0.7	-0.2	0.6
Number of self-reported non-cancer illnesses	0.8	1.5	4.5	1.2	2.1	0.3	1.1	0.2	-1.1
Average weekly champagne plus white wine intake	1.3	1.8	2.8	-1.6	-0.6	-1.2	-1.7	-1.0	1.6
Miserableness	0.3	0.5	0.9	0.8	0.6	0.1	0.9	-0.7	-0.9
Guilty feelings	0.1	0.2	0.6	0.0	0.4	-0.4	0.1	-0.8	-0.1
Wears glasses or contact lenses	0.2	0.2	0.5	-0.3	-0.7	-0.4	-0.4	-0.3	0.3
Ever taken oral contraceptive pill	3.2	3.5	4.7	2.0	2.0	1.5	2.1	1.4	-2.2
Hearing aid user	0.1	0.1	0.2	-0.4	0.5	-0.4	-0.2	-0.3	0.2
Mother’s age at death	0.6	0.8	1.4	-1.2	-1.0	-0.6	-1.0	-0.1	1.0
Financial situation satisfaction	0.8	1.0	3.4	-0.5	-0.0	-1.0	-0.8	-1.9	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.6	0.4	0.4	0.8	0.3	1.3	-0.4
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.5	0.8	0.3	0.3	0.0	-0.3
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	-0.6	1.0	-0.3	-0.5	-0.1	0.4
Medication: Blood pressure	0.0	0.1	0.4	-0.0	0.3	-0.1	0.0	-0.6	0.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.2	-0.1	-1.5	-1.0	-0.2	-0.5	0.1
Supplements: Fish oil (including cod liver oil)	2.5	3.3	4.1	2.0	1.4	1.9	2.0	1.4	-2.0
High cholesterol (Self-reported)	0.3	0.6	0.8	0.7	0.9	0.5	0.8	0.9	-0.8
Medication: Bendroflumethiazide	1.4	2.1	3.2	-1.6	-0.8	-1.8	-1.6	-1.0	1.6
Medication: Paracetamol	0.1	0.2	0.8	0.2	0.0	-0.4	0.2	-0.9	-0.2
Medication: Lisinopril	0.6	0.8	1.5	0.8	0.3	1.2	0.8	1.1	-0.9
Medication: Atorvastatin	0.2	0.3	0.9	0.2	-0.8	0.5	0.0	1.0	0.0
Illnesses of father: High blood pressure	0.8	0.9	5.3	-0.1	-2.3	0.3	-0.3	0.0	0.4
Alcohol drinker status: Never	0.4	0.5	0.6	-0.7	-0.8	-0.6	-0.8	0.4	0.8
Ever smoked	0.1	0.2	0.4	-0.3	-0.5	0.1	-0.3	0.6	0.4
Basal metabolic rate	0.4	2.2	5.2	-0.7	1.0	-2.3	-0.9	-2.2	0.8
Leg fat percentage (left)	0.1	0.2	1.0	0.1	0.3	0.1	-0.1	1.0	0.0
Arm fat-free mass (left)	0.4	2.2	5.7	-0.6	0.8	-2.4	-0.7	-2.4	0.7
Number of operations (self-reported)	0.3	0.5	0.7	-0.7	0.1	-0.6	-0.8	-0.9	0.9
Average weekly beer plus cider intake	0.5	0.8	1.6	0.8	0.9	1.3	0.8	0.6	-0.6
Irritability	0.0	0.1	0.2	0.2	0.3	0.0	0.4	0.3	-0.3
Risk taking	0.0	0.1	0.3	-0.0	0.3	0.1	-0.1	-0.5	0.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.0	0.4	1.0	0.4	0.4	0.8	-0.4
Fractured/broken bones in last 5 years	3.1	4.0	6.2	-1.9	-1.3	-2.5	-1.9	-2.3	1.8
Age started oral contraceptive pill	0.2	0.2	0.7	0.4	0.9	0.1	0.2	-0.7	-0.2
Diastolic blood pressure, automated reading	1.1	3.3	4.6	2.1	1.6	2.0	1.9	1.5	-1.8
Ever depressed for a whole week	0.0	0.1	0.1	0.1	0.3	0.2	0.2	-0.4	-0.2
Unable to work because of sickness or disability	1.0	1.4	4.3	1.0	2.1	0.8	0.9	0.6	-1.0
Commuting to job workplace: Cycle	0.4	0.5	0.7	-0.7	-0.3	-0.8	-0.8	-0.6	0.8
Myopia	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.0	-0.2	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.5	-0.7	-0.7	0.2	-0.6	0.4	0.6
Cholesterol lowering medication	0.6	0.9	1.7	-1.3	0.0	-0.9	-1.1	-0.7	1.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.7	1.4	1.6	0.9	1.4	0.7	-1.3
Pain experienced in last month	0.1	0.2	0.9	0.2	1.0	0.5	0.1	0.5	-0.0
Supplements: Calcium	2.4	2.7	4.1	-1.9	-0.2	-1.6	-2.0	-1.4	2.0
Basal cell carcinoma (self-reported)	1.0	1.2	3.4	0.8	1.8	1.0	0.7	1.0	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.0	-0.3	0.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.7	-0.9	-1.1	-0.9	-0.9	-1.6	0.9
Heart disease (siblings)	0.8	0.9	2.3	0.9	-0.2	0.5	1.1	1.5	-1.0
Alcohol drinker status: Previous	0.1	0.1	0.4	0.4	0.1	0.0	0.3	-0.6	-0.2
Pack years of smoking	0.2	0.3	1.3	0.2	1.1	0.4	0.3	-0.1	-0.2
Impedance of whole body	0.1	0.4	0.9	-0.5	-1.0	0.7	-0.2	0.7	0.2
Leg fat mass (left)	0.0	0.1	0.3	-0.2	0.5	-0.6	-0.3	0.1	0.3
Arm predicted mass (left)	0.4	2.3	5.8	-0.7	0.5	-2.4	-0.8	-2.4	0.8