Hub : Genes

SMG9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.331 0.0500 1.5e-13 0.257 NA 0.281 NA 0.286 2.7e-19 NA 2.7e-21 NA 1.2e-21
2 GTEx Esophagus Muscularis 0.149 0.0520 4.2e-04 0.005 NA 0.051 NA 0.034 1.6e-01 NA 4.6e-04 NA 3.8e-03
3 GTEx Lung 0.178 0.0463 1.3e-05 0.072 NA 0.029 NA 0.047 3.7e-06 NA 2.7e-03 NA 1.6e-04
4 GTEx Muscle Skeletal 0.134 0.0371 4.5e-05 0.096 NA 0.096 NA 0.094 1.0e-09 NA 1.1e-09 NA 1.6e-09
5 GTEx Nerve Tibial 0.139 0.0453 4.8e-04 0.026 NA 0.053 NA 0.082 5.9e-03 NA 1.2e-04 NA 2.0e-06
6 GTEx Testis 0.341 0.0690 3.9e-06 0.258 NA 0.264 NA 0.263 7.5e-12 NA 4.0e-12 NA 4.6e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 1.8 -0.5 -0.2 -0.3 -0.6 -1.4 0.6
Bipolar Disorder or Schizophrenia 0.0 0.0 0.1 0.3 0.0 0.2 0.3 -0.1 -0.2
Depressed Affect (Nagel 2018) 0.6 1.3 5.5 -0.3 -0.8 -1.1 -0.3 -2.3 0.4
Depression (Nagel 2018) 0.7 1.1 4.6 -0.2 0.1 -1.4 -0.1 -2.1 0.1
Intelligence (Savage-Jansen 2018) 0.3 1.0 4.2 -0.4 -0.0 -1.2 -0.4 -2.0 0.3
Neuroticism (Nagel 2018) 0.2 0.5 2.7 0.2 -0.5 -0.3 0.1 -1.6 -0.1
Schizophrenia (2018) 0.2 0.5 0.7 0.8 0.5 0.5 0.8 0.8 -0.8
Schizophrenia vs Biploar Disorder 2.1 2.7 3.9 1.7 1.7 1.2 1.6 2.0 -1.6
Worry (Nagel 2018) 0.0 0.1 0.2 0.2 -0.2 0.5 0.3 -0.4 -0.2
Alzheimer’s Disease (in mother) 0.4 0.4 1.3 0.5 1.1 0.3 0.6 0.3 -0.7
Alzheimer’s Disease (in father) 0.7 0.7 1.3 -1.1 -0.2 -0.8 -0.9 -0.8 1.0
Alzheimer’s Disease (including proxy) 0.3 0.4 1.6 -0.5 1.3 0.0 -0.3 0.3 0.4
Crohns Disease (2017) 0.4 0.8 1.3 1.1 1.1 0.6 0.9 0.7 -0.9
Irritable Bowel Disease (IBD) 1.3 3.0 7.1 1.6 1.1 1.9 1.3 2.7 -1.3
Ulcerative Colitis (UC) 1.1 2.1 7.8 1.0 0.1 1.6 0.8 2.8 -0.7
Major Depression (MDD) 1.2 1.5 3.0 1.1 1.7 1.1 1.3 0.4 -1.3
Reaction Time 0.3 0.6 3.2 0.1 -1.8 -0.1 -0.0 -0.4 0.0
Verbal and Numeric Reasoning (VNR) 0.3 0.6 2.3 0.5 1.5 0.3 0.5 -0.6 -0.6
Breast Cancer 2.1 5.2 25.6 0.8 5.1 1.3 1.0 1.0 -1.1
Ovarian Cancer 0.2 0.3 0.5 -0.4 0.5 -0.6 -0.4 -0.7 0.4
Prostate Cancer 1.0 1.4 1.8 1.3 0.7 1.3 1.2 1.2 -1.3
Age at First Birth 1.7 2.5 5.5 -1.5 -1.0 -2.3 -1.3 -1.8 1.3
Bipolar Disorder (2011) 0.7 0.7 1.5 0.8 0.4 1.2 0.9 0.2 -0.9
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -0.6 -0.1 -1.0 -0.7 -0.6 0.6
Coronary Artery Disease (CAD) 5.9 7.0 9.5 3.1 0.9 2.5 2.9 3.1 -2.8
Crohns Disease (2012) 0.3 0.5 1.2 -0.5 0.1 -0.8 -0.6 -1.1 0.5
Mean Putamen Volume 1.1 1.2 1.9 1.1 0.3 1.4 1.1 1.3 -1.2
Fasting Glucose 0.2 0.2 1.0 -0.1 1.0 0.2 -0.1 -0.5 -0.1
HbA1C 0.2 0.2 0.8 -0.1 0.9 -0.6 -0.4 0.3 0.3
HDL Cholesterol 0.1 0.1 0.2 0.2 -0.5 -0.1 0.3 0.2 -0.3
LDL Cholesterol 0.7 1.2 2.5 -1.1 0.6 -1.6 -1.1 -0.6 1.1
Lupus 0.3 0.4 1.0 -0.5 1.0 -0.3 -0.4 -1.0 0.4
Neuroticism (2016) 0.1 0.1 0.3 0.2 -0.5 0.3 0.2 -0.6 -0.1
Primary Biliary Cirrhosis 0.3 0.4 1.9 -0.2 0.0 -0.8 -0.1 -1.4 0.1
Rheumatoid Arthritis 4.5 6.2 9.0 -3.0 -1.4 -2.4 -2.9 -2.0 2.9
Schizophrenia (2014) 0.1 0.2 0.5 0.5 0.4 0.4 0.6 0.2 -0.7
Triglycerides 0.1 0.2 0.4 -0.0 0.5 -0.4 -0.3 -0.6 0.3
Type 2 Diabetes (T2D) (2012) 2.4 2.8 3.8 1.9 1.3 1.5 2.0 1.3 -1.9
Ulcerative Colitis 2.2 3.2 9.1 1.2 0.9 2.3 1.2 3.0 -1.2
Blood Eosinophil Count 0.1 0.4 1.8 0.4 1.3 0.4 0.3 0.6 -0.2
Blood Platelet Count 0.9 11.0 12.7 3.6 3.0 3.3 3.5 3.1 -3.5
Blood Red Count 7.3 70.7 88.7 9.4 5.5 8.2 9.4 7.8 -9.4
Blood White Count 2.5 18.5 30.6 5.1 4.0 3.0 5.4 0.2 -5.5
Heel T-Score 0.3 2.6 6.8 -0.7 2.5 1.3 -0.5 2.6 0.5
BMI 0.1 0.6 1.0 1.0 0.8 -0.0 0.7 0.9 -0.8
Height 1.4 26.1 59.8 -4.5 -0.8 -6.3 -4.3 -7.7 4.2
Waist Hip Ratio (WHR) 1.4 6.5 12.2 2.3 3.5 2.2 2.4 2.3 -2.3
Systolic Blood Pressure 0.0 0.2 0.3 0.4 0.2 0.5 0.3 0.5 -0.3
Smoking Status 0.4 0.8 1.9 0.7 0.0 1.1 0.9 1.4 -0.8
Allergy or Eczema 0.6 1.7 6.8 -0.4 0.7 -1.4 -0.6 -2.6 0.7
Cardiovascular Disease 2.3 7.6 9.1 3.0 2.7 2.6 3.0 2.2 -3.0
Hypothyroidism (self reported) 0.9 2.0 3.0 1.5 1.7 1.4 1.5 0.9 -1.4
Respiratory disease 0.1 0.1 0.3 0.1 0.4 -0.6 -0.0 -0.6 0.0
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.9 0.9 0.1 0.5 0.7 0.2 -0.7
Lung FEV1/FVC ratio 0.1 0.7 1.1 0.8 1.0 0.5 1.1 0.3 -1.1
Lung FVC 0.2 0.9 1.4 -1.2 -1.0 -0.2 -1.2 0.2 1.2
Neuroticism 0.1 0.2 0.6 0.1 -0.5 -0.4 0.2 -0.8 -0.2
Chronotype (morning person) 2.0 4.5 10.8 -2.0 -3.3 -1.7 -2.0 -1.1 2.0
Hair Pigment 0.1 4.3 13.7 -1.5 -3.7 -1.4 -1.4 -1.8 1.5
Tanning 0.0 0.5 1.2 -0.4 0.6 -0.5 -0.7 -1.1 0.6
Hand grip strength (left) 0.2 0.6 2.3 0.6 1.5 0.4 0.6 -0.5 -0.6
Number of treatments/medications taken 0.4 0.8 3.6 0.6 1.9 0.4 0.6 0.1 -0.5
Average weekly spirits intake 0.3 0.4 0.5 -0.7 0.0 -0.6 -0.6 -0.7 0.7
Sensitivity / hurt feelings 0.2 0.4 0.6 0.6 -0.7 0.5 0.5 0.8 -0.6
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.3 0.4 0.9 -1.3 0.3 -1.8 -0.3
Hearing difficulty/problems: Yes 0.5 0.8 1.7 1.0 1.3 0.7 0.9 0.3 -0.9
Relative age of first facial hair 0.2 0.4 0.7 0.5 0.5 0.6 0.7 0.3 -0.8
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 2.0 1.4 0.3 1.3 1.3 1.3 -1.3
Ever used hormone-replacement therapy (HRT) 1.6 2.1 6.1 -1.3 0.1 -1.4 -1.1 -2.5 1.2
Ever had hysterectomy (womb removed) 0.1 0.2 0.3 -0.6 0.4 -0.0 -0.5 0.2 0.4
Systolic blood pressure, automated reading 0.0 0.1 0.2 -0.2 -0.4 -0.2 -0.4 -0.0 0.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.9 0.9 -0.4 -0.1 0.8 0.1 -0.8
Angina 3.4 4.5 5.8 2.2 0.3 2.3 2.4 2.4 -2.3
Medication for hormone replacement therapy 2.2 2.4 3.2 1.5 1.0 1.5 1.7 1.7 -1.8
Vitamin and mineral supplements 0.6 0.8 1.3 -1.1 -0.9 -0.6 -1.2 -0.2 1.1
Supplements: Zinc 0.7 0.7 1.2 -0.7 0.0 -1.1 -0.9 -0.9 1.0
Medication: Co-codamol 0.2 0.3 1.4 0.1 0.2 0.1 -0.0 -1.2 -0.0
Medication: Metformin 0.6 0.9 1.5 1.2 0.3 0.8 1.2 0.6 -1.2
Diabetes (father) 0.2 0.2 1.3 -0.1 -1.1 0.1 -0.2 -0.0 0.2
Diabetes (mother) 0.3 0.4 0.7 0.8 0.5 0.1 0.9 0.2 -0.8
Severe depression (siblings) 0.6 0.6 0.9 1.0 0.5 0.7 0.9 0.6 -0.9
Pack years adult smoking proportion 0.1 0.2 0.9 0.3 1.0 0.3 0.3 -0.1 -0.2
Impedance of leg (right) 0.3 1.3 3.0 0.8 -0.3 1.7 1.0 1.4 -0.9
Leg fat-free mass (left) 0.4 2.0 4.7 -0.8 0.9 -2.2 -0.8 -2.1 0.8
Trunk fat percentage 0.0 0.1 0.2 -0.4 -0.1 -0.4 -0.4 0.4 0.3
Hand grip strength (right) 0.6 1.7 3.6 1.5 1.9 0.7 1.4 0.2 -1.4
Townsend deprivation index at recruitment 1.4 1.9 2.9 1.7 -0.1 1.5 1.5 1.4 -1.4
Current tobacco smoking 0.1 0.2 0.4 0.2 -0.6 0.3 0.5 -0.2 -0.4
Average weekly fortified wine intake 0.2 0.2 1.1 -0.1 1.0 0.1 0.0 -0.1 0.1
Maternal smoking around birth 0.2 0.3 1.3 0.3 1.1 -0.3 0.4 0.1 -0.3
Fed-up feelings 0.4 0.7 2.7 -0.2 0.0 -1.1 -0.2 -1.6 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.5 0.2 0.1 -1.0 0.2 -1.2 -0.3
Relative age voice broke 1.0 1.6 2.3 1.2 0.8 1.5 1.4 1.1 -1.5
Taking other prescription medications 0.1 0.2 1.1 0.2 1.0 0.0 0.1 0.1 -0.1
Age when periods started (menarche) 3.0 7.2 8.5 2.9 2.3 2.8 2.8 2.4 -2.8
Bilateral oophorectomy (both ovaries removed) 2.2 2.6 3.7 -1.9 -1.5 -1.5 -1.8 -1.0 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 4.4 0.2 2.1 0.8 0.3 1.1 -0.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.3 0.4 0.7 0.4 0.3 -0.4
Qualifications: CSEs or equivalent 0.8 1.1 3.0 0.8 0.5 1.2 0.8 1.7 -0.8
Serious illness, injury or assault to yourself 0.6 0.8 1.2 -0.8 -0.5 -1.1 -0.8 -1.1 0.7
High blood pressure 0.2 0.4 0.8 0.8 0.9 0.2 0.7 -0.1 -0.8
Hayfever, allergic rhinitis or eczema 0.9 1.9 6.6 -0.7 0.9 -1.3 -0.9 -2.6 0.9
Multivitamins +/- minerals 2.0 2.5 4.2 2.0 1.0 1.1 2.1 1.0 -2.0
Stomach or abdominal pain in last month 0.3 0.4 0.9 0.6 0.9 0.2 0.7 -0.5 -0.7
Supplements: Glucosamine 0.5 0.7 1.3 -1.0 -0.1 -0.4 -1.1 -0.8 1.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 1.8 1.2 1.0 0.9 1.3 0.9 -1.3
Medication: Atenolol 6.5 8.1 12.4 3.5 1.4 2.8 3.4 1.8 -3.4
Medication: Levothyroxine sodium 2.5 4.3 6.8 1.8 2.6 2.4 1.8 1.9 -1.7
Sitting height 0.2 1.7 3.3 -0.9 1.7 -1.6 -0.7 -1.8 0.7
Chronic bronchitis/emphysema (father) 0.9 1.0 1.4 1.2 1.2 0.5 1.1 0.6 -1.2
High blood pressure (mother) 0.1 0.1 0.5 0.2 -0.7 -0.2 0.1 0.0 0.0
Body mass index (BMI) 0.1 0.3 0.7 0.5 0.8 -0.1 0.2 0.7 -0.3
Impedance of leg (left) 0.1 0.7 1.7 0.3 -0.5 1.3 0.5 1.3 -0.5
Leg predicted mass (left) 0.4 1.9 4.5 -0.7 0.9 -2.1 -0.8 -2.1 0.7
Trunk fat mass 0.1 0.3 0.8 -0.5 0.3 -0.9 -0.5 -0.1 0.4
Waist circumference 0.1 0.3 1.6 0.2 1.2 -0.2 0.1 0.5 -0.1
Number of incorrect matches in round 0.8 1.4 2.7 -1.0 -1.1 -1.2 -0.9 -1.6 1.0
Past tobacco smoking 0.8 1.4 4.1 -1.0 -0.2 -1.3 -0.9 -2.0 0.9
Alcohol usually taken with meals 0.1 0.2 1.1 0.0 1.0 0.2 0.1 0.1 -0.2
Nervous feelings 0.3 0.5 1.1 -0.5 -1.0 -0.3 -0.7 -0.7 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.9 0.3 0.1 -0.3 0.5 -0.9 -0.5
Hearing difficulty/problems with background noise 0.3 0.6 2.5 0.5 1.6 0.2 0.5 -0.1 -0.5
Hair/balding pattern: Pattern 2 0.1 0.2 0.7 0.1 -0.5 0.2 -0.1 0.9 -0.0
Had menopause 2.3 2.9 3.5 -1.8 -1.7 -1.9 -1.6 -1.5 1.7
Had other major operations 0.9 1.1 1.8 1.3 0.2 0.9 1.3 0.7 -1.3
Forced vital capacity (FVC) 0.4 1.7 3.1 -1.0 -1.5 -1.3 -1.0 -1.8 1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 2.3 -0.3 1.5 0.2 -0.2 0.4 0.1
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 0.7 0.3 0.8 0.7 0.6 -0.7
Qualifications: None of the above 0.4 0.8 3.5 -0.3 -1.9 -0.2 -0.3 -1.0 0.4
Financial difficulties in last 2 years 0.9 1.3 2.5 1.1 1.6 -0.1 0.9 -1.6 -0.8
Mouth/teeth dental problems 1.0 1.6 6.0 0.9 2.5 1.2 0.8 0.3 -0.7
Heart attack 0.1 0.2 0.4 -0.2 -0.4 -0.6 -0.1 -0.5 0.3
Allergy 0.7 1.6 3.9 1.0 -0.7 1.2 1.3 2.0 -1.2
Pain all over the body in last month 0.7 0.7 1.0 -1.0 -0.9 -0.7 -1.0 -0.3 0.9
Diabetes (self-reported) 0.2 0.3 0.9 0.6 0.9 -0.1 0.4 -0.4 -0.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.8 -0.4 1.4 -0.1 -0.6 -0.5 0.7
Medication: Ramipril 0.2 0.3 0.6 0.8 0.8 0.2 0.4 0.1 -0.4
Medication: Simvastatin 0.4 0.6 1.4 0.6 1.2 0.4 0.9 0.7 -0.9
Fluid intelligence score 0.1 0.1 0.5 -0.2 0.5 -0.2 -0.2 -0.7 0.1
Illnesses of siblings 1.4 2.0 2.9 -1.4 -0.2 -1.4 -1.7 -1.6 1.7
Neuroticism score 0.4 0.9 2.5 -0.6 -0.5 -1.1 -0.7 -1.6 0.7
Weight 0.2 0.9 2.3 -0.6 0.9 -1.5 -0.7 -1.1 0.6
Impedance of arm (right) 0.2 0.7 1.5 -1.2 -1.0 0.2 -0.9 0.4 0.9
Arm fat percentage (right) 0.1 0.2 0.4 -0.5 0.0 -0.3 -0.6 0.6 0.5
Trunk fat-free mass 0.5 2.8 6.8 -0.8 1.0 -2.5 -1.0 -2.6 1.0
Hip circumference 0.3 1.1 2.5 -1.0 -0.2 -1.6 -1.2 -0.7 1.1
Time employed in main current job 0.5 0.6 2.8 0.4 1.7 -0.2 0.6 0.0 -0.5
Alcohol intake versus 10 years previously 0.5 0.8 1.4 1.0 -0.1 1.2 0.9 0.7 -0.9
Father’s age at death 4.4 5.9 10.0 -2.4 -1.9 -2.4 -2.2 -3.2 2.3
Worrier / anxious feelings 0.1 0.1 0.2 -0.3 0.1 -0.3 -0.5 -0.4 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.9 1.0 1.7 0.6 1.0 0.8 -1.0
Falls in the last year 0.2 0.3 1.6 -0.1 1.3 -0.4 0.0 -0.4 -0.0
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 0.2 -0.3 -0.4 0.2 -0.4 -0.1
Number of live births 0.2 0.3 0.9 -0.3 -0.9 -0.5 -0.3 0.8 0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.2 -0.3 -0.9 -0.8 -0.2 -1.1 0.2
Pulse rate 0.6 1.0 1.7 -1.2 -0.7 -0.6 -1.3 -0.2 1.3
Happiness 0.4 0.4 1.9 0.5 0.3 -0.1 0.5 -1.4 -0.4
Noisy workplace 0.4 0.5 1.8 -0.6 -1.3 0.3 -0.6 -0.1 0.6
Qualifications: A levels/AS levels or equivalent 2.2 4.8 6.5 1.8 2.6 2.6 1.9 2.3 -1.9
Serious illness, injury or assault of a close relative in last 2 years 4.3 4.9 7.0 2.2 2.6 2.2 1.8 2.6 -1.6
Mouth/teeth dental problems: Dentures 1.0 1.7 7.6 -0.6 -2.8 -0.9 -0.7 -0.8 0.6
Asthma 0.4 0.7 3.3 -0.2 1.8 -0.3 -0.5 -0.8 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.5 -0.7 0.4 -0.7 -0.7 -0.5 0.7
Medication: Cholesterol lowering 3.3 5.1 5.8 2.4 1.8 2.1 2.4 2.4 -2.4
Depression (self-reported) 0.4 0.5 2.1 -0.1 0.2 -0.9 0.0 -1.5 -0.0
Medication: Lansoprazole 1.5 1.7 3.0 -1.1 -0.4 -1.7 -1.3 -1.4 1.4
Prospective memory result 0.3 0.3 0.8 0.5 0.9 0.0 0.5 -0.5 -0.5
Lung cancer (father) 0.5 0.6 0.8 -0.9 -0.7 -0.8 -0.8 -0.7 0.7
Illnesses of mother 0.2 0.2 0.4 -0.3 -0.5 -0.1 -0.6 -0.4 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.5 -0.9 -0.2 -1.0 -0.9 -1.6 0.8
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 -0.4 0.3 -0.1 -0.4 -0.5 0.4
Impedance of arm (left) 0.1 0.7 1.5 -1.2 -0.9 0.2 -0.9 0.3 0.9
Arm fat mass (right) 0.1 0.4 0.9 -0.7 0.3 -0.9 -0.8 -0.1 0.7
Trunk predicted mass 0.5 2.8 6.9 -0.9 0.9 -2.5 -1.0 -2.6 1.0
Standing height 0.7 6.9 17.3 -2.3 0.3 -3.3 -2.0 -4.2 2.0
Length of working week for main job 0.4 0.5 0.9 0.9 0.4 0.5 0.9 -0.0 -0.9
Exposure to tobacco smoke at home 1.3 1.5 7.5 -0.6 -2.7 -0.2 -0.6 -0.6 0.6
Breastfed as a baby 2.5 3.1 4.9 -1.8 1.5 -1.4 -1.8 -2.2 1.8
Tense / ‘highly strung’ 0.1 0.2 1.0 0.2 -0.1 -0.1 0.4 -1.0 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.3 0.1 0.2 -0.7 -0.1 -1.1 0.0
Hair/balding pattern: Pattern 4 0.0 0.1 0.4 0.2 0.4 0.2 -0.0 -0.6 0.1
Birth weight of first child 0.4 0.7 2.2 0.1 1.5 -0.5 -0.0 -1.3 -0.1
Peak expiratory flow (PEF) 0.2 0.4 1.5 0.1 -1.2 -0.4 0.3 -0.7 -0.4
Pulse wave reflection index 0.3 0.3 1.1 -0.1 0.7 -0.3 -0.2 -1.1 0.3
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.1 1.1 0.2 0.7 1.0 0.1 -0.9
Loud music exposure frequency 0.9 1.0 2.3 0.8 1.5 0.9 0.8 1.0 -0.8
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.3 0.5 1.2 0.9 0.4 1.5 -0.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.4 0.3 -1.2 -0.1 0.5 1.0 -0.6
Blood clot in the leg (DVT) 1.1 1.4 3.6 -1.0 -0.9 -1.0 -0.9 -1.9 0.9
Medication: Paracetamol 0.2 0.4 1.3 -0.1 -0.5 -0.8 -0.1 -1.1 0.2
Headache pain in last month 1.0 1.7 3.2 -1.3 -1.8 -1.2 -1.2 -1.2 1.2
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 4.7 -2.1 -1.7 -1.6 -2.1 -1.5 2.2
Glaucoma (self-reported) 0.4 0.5 2.9 -0.2 1.7 -0.0 -0.2 -0.1 0.1
Gout (self-reported) 0.6 0.8 2.2 0.5 0.9 1.2 0.5 1.5 -0.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.8 1.0 1.3 0.9 1.1 0.2 -1.0
Medication: Amlodipine 0.3 0.4 0.7 0.8 0.7 0.1 0.7 -0.3 -0.7
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.0 0.4 -0.1 -0.3 -0.3 0.3
Birth weight 0.1 0.2 0.4 0.6 -0.1 -0.2 0.5 -0.7 -0.6
Chronic bronchitis/emphysema (mother) 3.9 4.5 6.5 2.4 0.4 1.9 2.5 2.2 -2.5
High blood pressure (siblings) 0.6 0.9 1.4 1.0 0.3 0.8 1.2 0.8 -1.2
Forced vital capacity (FVC), Best measure 0.9 3.3 5.4 -1.9 -1.2 -1.8 -1.8 -2.3 1.8
Body fat percentage 0.0 0.1 0.3 -0.2 -0.0 -0.2 -0.2 0.6 0.1
Leg fat percentage (right) 0.1 0.2 0.9 0.3 0.3 0.3 0.1 1.0 -0.2
Arm fat-free mass (right) 0.3 1.3 3.7 -0.1 0.9 -1.9 -0.3 -1.9 0.3
Exposure to tobacco smoke outside home 0.4 0.5 1.0 0.8 -0.6 0.7 1.0 -0.1 -0.9
Comparative body size at age 10 0.3 0.9 1.3 -1.0 -0.3 -0.9 -1.1 -0.8 1.1
Number of full brothers 0.2 0.2 0.8 0.4 -0.4 0.1 0.3 0.9 -0.4
Worry too long after embarrassment 0.6 1.0 1.8 -0.8 -0.1 -1.3 -1.1 -1.3 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.6 -0.8 0.3 -0.7 -0.8 -0.7 0.7
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 -0.2 0.4 -0.5 -0.2 -0.4 0.1
Number of children fathered 0.3 0.3 0.7 0.7 0.2 0.3 0.8 0.1 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.7 0.7 1.6 -0.1 0.8 0.5 -0.8
Age at first live birth 0.9 1.5 2.5 -1.5 0.3 -0.9 -1.5 -1.2 1.6
Pulse wave peak to peak time 0.1 0.1 0.2 0.3 -0.2 -0.1 0.4 0.3 -0.4
Health satisfaction 0.8 1.0 1.7 1.3 1.0 0.9 1.1 0.2 -1.2
Shortness of breath walking on level ground 0.5 0.5 0.7 -0.5 -0.6 -0.9 -0.7 -0.8 0.8
Qualifications: College or University degree 1.6 5.0 10.1 1.8 3.2 2.0 2.1 1.7 -2.1
Eye problems/disorders: None of the above 0.4 0.4 1.3 0.6 1.1 0.4 0.6 0.3 -0.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.0 0.6 1.0 0.4 0.8 0.2 -0.8
Emphysema/chronic bronchitis 1.4 1.6 3.5 1.2 -0.6 1.1 1.2 1.9 -1.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.6 -0.5 -0.8 -0.1 -0.4 0.3 0.3
Neck or shoulder pain in last month 0.0 0.0 0.1 0.2 -0.3 -0.1 0.2 0.3 -0.1
Medication: Blood pressure 0.6 1.1 1.9 1.4 1.0 0.6 1.3 0.3 -1.4
Angina (self-reported) 3.3 4.4 6.3 2.1 -0.1 2.4 2.2 2.5 -2.2
Migraine (self-reported) 0.9 1.1 1.9 -1.4 -0.8 -0.8 -1.3 -0.4 1.4
Medication: Ibuprofen 0.3 0.4 0.6 -0.8 -0.1 -0.6 -0.7 -0.5 0.7
Medication: Allopurinol 0.1 0.1 0.1 0.3 0.4 0.3 0.3 0.3 -0.2
Medication: Omeprazole 1.9 2.2 5.0 1.4 2.2 1.1 1.5 0.8 -1.5
Medication: Seretide 50 evohaler 3.9 4.5 6.7 -2.6 -1.1 -1.8 -2.5 -1.8 2.5
Mean time to correctly identify matches 0.6 1.1 3.8 -0.7 -2.0 -0.6 -0.7 -0.8 0.7
Heart disease (mother) 0.1 0.2 0.4 -0.4 0.0 -0.6 -0.2 -0.6 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.9 0.6 0.8 0.0 0.8 0.9 -0.8
Whole body fat mass 0.0 0.1 0.5 -0.3 0.2 -0.7 -0.4 0.1 0.3
Leg fat mass (right) 0.0 0.1 0.3 0.0 0.6 -0.4 -0.1 0.2 0.0
Arm predicted mass (right) 0.4 1.9 5.3 -0.4 0.4 -2.2 -0.6 -2.3 0.5
Pulse rate, automated reading 0.5 1.5 3.2 0.9 0.7 1.4 1.0 1.8 -1.0
Alcohol intake frequency. 1.6 3.7 8.8 -1.8 -3.0 -1.9 -1.7 -0.7 1.8
Comparative height size at age 10 0.9 5.1 12.1 -2.0 -0.7 -2.9 -1.8 -3.5 1.8
Number of full sisters 0.2 0.3 1.5 -0.0 1.2 0.2 -0.1 0.5 0.0
Suffer from ‘nerves’ 0.6 0.9 2.7 -1.0 0.1 -0.4 -0.9 -1.6 0.9
Overall health rating 0.0 0.1 0.1 0.2 0.1 -0.3 0.2 -0.3 -0.2
Chest pain or discomfort 0.1 0.2 0.3 0.4 0.1 -0.0 0.4 0.6 -0.5
Had major operations 0.4 0.5 0.8 -0.9 -0.1 -0.6 -0.9 -0.2 0.9
Age at last live birth 0.6 0.8 1.2 -1.1 0.2 -0.9 -1.1 -0.8 1.1
Family relationship satisfaction 1.4 1.8 3.4 -0.8 -1.5 -1.5 -1.0 -1.8 1.0
Leg pain on walking 1.2 1.5 2.6 1.4 0.9 1.0 1.5 0.7 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.1 0.1 -0.5 -0.4 0.1 0.3
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.4 0.2 1.2 -0.0 0.3 0.3 -0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.7 -0.8 -1.6 -0.2 -0.8 0.4 0.8
Medication: Aspirin 0.4 0.6 0.7 0.7 0.9 0.8 0.7 0.8 -0.7
Supplements: Vitamin C 0.5 0.6 1.4 -1.2 -0.3 -0.7 -0.9 -0.4 0.9
Knee pain experienced in last month 1.5 2.4 3.5 -1.4 -1.9 -1.8 -1.3 -1.6 1.2
Hypertension (Self-reported) 0.3 0.9 1.5 1.1 1.2 0.6 1.0 0.1 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.1 0.7 1.0 -0.8 0.5 -0.4 -0.5
Illnesses of father: Heart disease 0.4 0.5 0.9 -0.8 -0.9 -0.6 -0.8 0.1 0.8
Illnesses of siblings: Diabetes 0.4 0.5 0.9 -0.9 -0.4 -0.9 -0.8 -0.3 0.8
Smoking status: Previous 1.1 1.6 3.5 1.3 0.8 1.1 1.1 1.9 -1.1
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 6.4 -1.1 -0.6 -1.4 -1.1 -2.5 1.1
Whole body fat-free mass 0.4 2.5 6.0 -0.8 1.0 -2.4 -0.9 -2.4 0.8
Leg fat-free mass (right) 0.4 2.3 5.3 -1.0 0.8 -2.3 -1.0 -2.3 0.9
Arm fat percentage (left) 0.0 0.2 0.5 -0.4 -0.0 -0.2 -0.5 0.7 0.3
Average weekly red wine intake 1.0 1.4 3.6 0.6 1.9 1.3 0.9 1.3 -0.9
Handedness (chirality/laterality): Left-handed 1.1 1.3 1.7 -1.3 -0.9 -0.9 -1.2 -1.1 1.3
Mood swings 0.9 1.6 3.6 -1.1 -0.9 -1.4 -1.1 -1.9 1.1
Loneliness, isolation 0.4 0.5 1.8 0.1 -0.8 -0.8 0.1 -1.3 -0.1
Long-standing illness, disability or infirmity 1.4 2.1 2.6 1.6 1.2 1.5 1.5 1.4 -1.6
Ever had bowel cancer screening 0.2 0.2 1.0 0.2 -0.4 -0.2 0.2 -1.0 -0.2
Diabetes diagnosed by doctor 0.2 0.4 0.7 0.8 0.9 0.1 0.6 -0.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.1 0.2 0.0 -0.0 0.2 -0.0 -0.2
Friendships satisfaction 0.9 1.1 2.7 -0.8 -1.7 -0.7 -1.0 -0.7 1.0
Qualifications: nursing, teaching 0.6 0.9 2.2 -0.9 1.5 -0.9 -0.8 -0.6 0.8
Commuting to job workplace: Walk 0.1 0.1 0.3 0.1 -0.6 0.3 -0.2 0.4 0.1
Eye problems/disorders: Cataract 1.3 1.5 3.6 -1.1 -1.9 -1.0 -1.1 -0.7 1.1
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 4.1 -1.8 -1.3 -0.9 -2.0 -0.5 1.9
Medication for cholesterol 0.6 0.9 1.9 -0.5 -1.4 -1.0 -0.8 -0.9 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.4 0.0 0.6 0.4 0.2 0.1 -0.2
Back pain experienced in last month 0.2 0.3 0.4 0.6 0.6 0.4 0.5 0.6 -0.6
Mineral and other dietary supplements 0.9 1.2 1.7 -1.1 -1.3 -1.2 -1.1 -0.6 1.1
Breast cancer (self-reported) 0.7 0.9 2.4 -0.7 -1.6 -0.8 -0.8 -0.4 0.8
Asthma (self-reported) 0.4 0.8 2.2 -0.4 1.5 -0.6 -0.7 -1.0 0.6
Osteoporosis (self-reported) 0.2 0.2 0.6 0.5 0.5 0.7 0.3 -0.2 -0.4
Osteoarthritis (self-reported) 1.3 1.7 4.7 1.0 0.0 1.2 1.1 2.2 -1.2
Medication: Aspirin 1.1 1.4 1.9 1.2 0.9 1.2 1.2 1.4 -1.2
Medication: Gliclazide 0.4 0.4 0.8 0.7 -0.3 0.7 0.6 0.9 -0.6
Illnesses of father: None of the above (group 1) 0.5 0.6 2.2 0.5 1.5 0.7 0.6 0.3 -0.5
Smoking status: Current 0.2 0.3 0.6 0.3 -0.8 0.6 0.6 0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.0 -0.6 -0.6 -1.0 -0.5 -1.4 0.5
Whole body water mass 0.4 2.5 6.2 -0.8 1.0 -2.4 -0.9 -2.5 0.8
Leg predicted mass (right) 0.4 2.4 5.6 -1.0 0.8 -2.4 -1.0 -2.3 1.0
Arm fat mass (left) 0.1 0.4 0.9 -0.6 0.4 -0.9 -0.7 -0.2 0.6
Number of self-reported non-cancer illnesses 0.8 1.5 4.5 1.2 2.1 0.3 1.1 0.2 -1.1
Average weekly champagne plus white wine intake 1.3 1.8 2.8 -1.6 -0.6 -1.2 -1.7 -1.0 1.6
Miserableness 0.3 0.5 0.9 0.8 0.6 0.1 0.9 -0.7 -0.9
Guilty feelings 0.1 0.2 0.6 0.0 0.4 -0.4 0.1 -0.8 -0.1
Wears glasses or contact lenses 0.2 0.2 0.5 -0.3 -0.7 -0.4 -0.4 -0.3 0.3
Ever taken oral contraceptive pill 3.2 3.5 4.7 2.0 2.0 1.5 2.1 1.4 -2.2
Hearing aid user 0.1 0.1 0.2 -0.4 0.5 -0.4 -0.2 -0.3 0.2
Mother’s age at death 0.6 0.8 1.4 -1.2 -1.0 -0.6 -1.0 -0.1 1.0
Financial situation satisfaction 0.8 1.0 3.4 -0.5 -0.0 -1.0 -0.8 -1.9 0.9
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.6 0.4 0.4 0.8 0.3 1.3 -0.4
Commuting to job workplace: Public transport 0.2 0.2 0.6 0.5 0.8 0.3 0.3 0.0 -0.3
Eye problems/disorders: Glaucoma 0.3 0.3 1.0 -0.6 1.0 -0.3 -0.5 -0.1 0.4
Medication: Blood pressure 0.0 0.1 0.4 -0.0 0.3 -0.1 0.0 -0.6 0.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 2.2 -0.1 -1.5 -1.0 -0.2 -0.5 0.1
Supplements: Fish oil (including cod liver oil) 2.5 3.3 4.1 2.0 1.4 1.9 2.0 1.4 -2.0
High cholesterol (Self-reported) 0.3 0.6 0.8 0.7 0.9 0.5 0.8 0.9 -0.8
Medication: Bendroflumethiazide 1.4 2.1 3.2 -1.6 -0.8 -1.8 -1.6 -1.0 1.6
Medication: Paracetamol 0.1 0.2 0.8 0.2 0.0 -0.4 0.2 -0.9 -0.2
Medication: Lisinopril 0.6 0.8 1.5 0.8 0.3 1.2 0.8 1.1 -0.9
Medication: Atorvastatin 0.2 0.3 0.9 0.2 -0.8 0.5 0.0 1.0 0.0
Illnesses of father: High blood pressure 0.8 0.9 5.3 -0.1 -2.3 0.3 -0.3 0.0 0.4
Alcohol drinker status: Never 0.4 0.5 0.6 -0.7 -0.8 -0.6 -0.8 0.4 0.8
Ever smoked 0.1 0.2 0.4 -0.3 -0.5 0.1 -0.3 0.6 0.4
Basal metabolic rate 0.4 2.2 5.2 -0.7 1.0 -2.3 -0.9 -2.2 0.8
Leg fat percentage (left) 0.1 0.2 1.0 0.1 0.3 0.1 -0.1 1.0 0.0
Arm fat-free mass (left) 0.4 2.2 5.7 -0.6 0.8 -2.4 -0.7 -2.4 0.7
Number of operations (self-reported) 0.3 0.5 0.7 -0.7 0.1 -0.6 -0.8 -0.9 0.9
Average weekly beer plus cider intake 0.5 0.8 1.6 0.8 0.9 1.3 0.8 0.6 -0.6
Irritability 0.0 0.1 0.2 0.2 0.3 0.0 0.4 0.3 -0.3
Risk taking 0.0 0.1 0.3 -0.0 0.3 0.1 -0.1 -0.5 0.0
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.0 0.4 1.0 0.4 0.4 0.8 -0.4
Fractured/broken bones in last 5 years 3.1 4.0 6.2 -1.9 -1.3 -2.5 -1.9 -2.3 1.8
Age started oral contraceptive pill 0.2 0.2 0.7 0.4 0.9 0.1 0.2 -0.7 -0.2
Diastolic blood pressure, automated reading 1.1 3.3 4.6 2.1 1.6 2.0 1.9 1.5 -1.8
Ever depressed for a whole week 0.0 0.1 0.1 0.1 0.3 0.2 0.2 -0.4 -0.2
Unable to work because of sickness or disability 1.0 1.4 4.3 1.0 2.1 0.8 0.9 0.6 -1.0
Commuting to job workplace: Cycle 0.4 0.5 0.7 -0.7 -0.3 -0.8 -0.8 -0.6 0.8
Myopia 0.0 0.0 0.0 -0.1 -0.0 -0.1 -0.0 -0.2 0.0
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.5 -0.7 -0.7 0.2 -0.6 0.4 0.6
Cholesterol lowering medication 0.6 0.9 1.7 -1.3 0.0 -0.9 -1.1 -0.7 1.1
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 2.7 1.4 1.6 0.9 1.4 0.7 -1.3
Pain experienced in last month 0.1 0.2 0.9 0.2 1.0 0.5 0.1 0.5 -0.0
Supplements: Calcium 2.4 2.7 4.1 -1.9 -0.2 -1.6 -2.0 -1.4 2.0
Basal cell carcinoma (self-reported) 1.0 1.2 3.4 0.8 1.8 1.0 0.7 1.0 -0.7
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 -0.0 -0.4 -0.4 -0.0 -0.3 0.1
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.7 -0.9 -1.1 -0.9 -0.9 -1.6 0.9
Heart disease (siblings) 0.8 0.9 2.3 0.9 -0.2 0.5 1.1 1.5 -1.0
Alcohol drinker status: Previous 0.1 0.1 0.4 0.4 0.1 0.0 0.3 -0.6 -0.2
Pack years of smoking 0.2 0.3 1.3 0.2 1.1 0.4 0.3 -0.1 -0.2
Impedance of whole body 0.1 0.4 0.9 -0.5 -1.0 0.7 -0.2 0.7 0.2
Leg fat mass (left) 0.0 0.1 0.3 -0.2 0.5 -0.6 -0.3 0.1 0.3
Arm predicted mass (left) 0.4 2.3 5.8 -0.7 0.5 -2.4 -0.8 -2.4 0.8