[Hub]/) : Traits : Arm fat-free mass (left) : ← →

chr2:23,453,834-29,344,127

Best TWAS P=3.35e-38 · Best GWAS P=1.49e-35 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-12.4	12.9	3.4e-38	-0.99	0.00	0.96	TRUE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	7.7	9.8	1.6e-22	-0.40	0.19	0.14	TRUE
35	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	7.6	-7.8	8.5e-15	-0.05	0.04	0.92	TRUE
11	GTEx	Breast Mammary Tissue (Female)	AC074117.10	0.06	0.01	lasso	2	0.04	2.7e-02	6.4	7.1	9.8e-13	-0.23	0.04	0.05	TRUE
40	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	4.7	-6.8	9.4e-12	0.15	0.50	0.16	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	4.5	-6.7	2.7e-11	0.72	0.28	0.72	TRUE
28	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-3.8	-6.3	2.5e-10	0.01	0.52	0.02	TRUE
15	GTEx	Colon Sigmoid	DNMT3A	0.19	-0.01	lasso	8	0.00	4.5e-01	-1.9	-6.1	1.1e-09	0.06	0.07	0.12	TRUE
18	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	4.6	-5.9	3.1e-09	0.64	0.43	0.30	TRUE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-5.0	-5.9	3.2e-09	0.01	0.00	0.79	TRUE
48	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	5.4	-5.8	7.2e-09	0.09	0.08	0.92	TRUE
59	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SUPT7L	0.06	0.03	blup	29	0.05	2.0e-03	7.7	5.4	5.6e-08	-0.04	0.04	0.04	TRUE
26	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	1.4	-5.4	8.3e-08	0.12	0.64	0.06	TRUE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP1CB	0.04	0.02	blup	39	0.02	1.6e-04	4.8	-5.1	3.0e-07	0.07	0.01	0.92	TRUE
69	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	7.9	10.7	6.2e-27	-0.70	0.41	0.59	FALSE
39	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	7.7	10.7	1.2e-26	-0.69	0.67	0.33	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	7.7	10.2	2.8e-24	-0.64	0.91	0.09	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	8.7	10.0	2.5e-23	-0.54	0.02	0.27	FALSE
38	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	4.8	-9.0	3.3e-19	0.85	0.05	0.94	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	-9.7	-8.3	1.3e-16	0.54	0.00	0.99	FALSE
36	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	5.8	8.2	3.2e-16	-0.36	0.20	0.08	FALSE
37	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	5.8	-8.0	1.3e-15	0.80	0.03	0.96	FALSE
23	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	5.8	-8.0	1.5e-15	0.82	0.01	0.97	FALSE
21	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	5.8	-7.6	2.2e-14	0.74	0.94	0.06	FALSE
33	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	4.7	-7.5	6.6e-14	0.77	0.04	0.80	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	5.2	7.0	2.2e-12	-0.63	0.43	0.49	FALSE
16	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-6.5	-7.0	3.1e-12	-0.06	0.07	0.70	FALSE
41	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	3.9	-6.8	7.5e-12	0.72	0.08	0.57	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	4.5	6.8	1.0e-11	-0.75	0.48	0.52	FALSE
25	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	-6.0	-6.7	2.1e-11	0.02	0.23	0.28	FALSE
20	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	1.4	-6.6	3.4e-11	0.05	0.10	0.17	FALSE
22	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-3.7	-6.4	2.1e-10	0.01	0.06	0.28	FALSE
44	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	5.8	-6.1	8.1e-10	0.67	1.00	0.00	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	-6.0	6.1	1.2e-09	-0.04	0.35	0.02	FALSE
4	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	5.8	-6.0	1.6e-09	0.65	0.45	0.27	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	2.7	6.0	1.6e-09	-0.55	0.02	0.34	FALSE
24	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	5.8	-6.0	1.7e-09	0.65	0.73	0.26	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	-6.0	6.0	2.4e-09	-0.03	0.36	0.14	FALSE
30	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	-2.1	-6.0	2.6e-09	0.43	0.29	0.07	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RP11-373D23.3	0.17	0.01	enet	15	0.04	1.2e-02	4.9	-5.9	3.9e-09	0.28	0.05	0.45	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	-7.0	5.9	4.1e-09	-0.03	1.00	0.00	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	-4.5	-5.9	4.1e-09	0.06	0.27	0.23	FALSE
60	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	5.8	-5.8	6.0e-09	0.67	0.02	0.09	FALSE
6	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-3.1	-5.8	6.3e-09	-0.01	0.07	0.04	FALSE
8	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	4.3	-5.7	9.2e-09	0.66	0.29	0.12	FALSE
29	GTEx	Lung	RP11-373D23.3	0.08	0.00	enet	21	0.02	2.3e-02	3.2	-5.7	1.3e-08	0.23	0.13	0.43	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	5.8	-5.7	1.6e-08	0.65	0.04	0.70	FALSE
27	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	-4.5	-5.6	1.8e-08	0.05	1.00	0.00	FALSE
53	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	4.8	-5.6	1.8e-08	0.61	0.99	0.00	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	4.6	-5.6	1.9e-08	0.66	0.03	0.51	FALSE
13	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	5.2	-5.6	2.1e-08	0.61	0.95	0.04	FALSE
32	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	5.8	-5.6	2.3e-08	0.61	0.28	0.61	FALSE
9	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	5.2	-5.4	5.1e-08	0.62	0.99	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	5.8	-5.4	5.1e-08	0.66	0.87	0.13	FALSE
34	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-6.4	-5.4	5.4e-08	-0.08	0.03	0.88	FALSE
43	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	4.5	5.4	6.2e-08	-0.52	0.96	0.03	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	-4.5	5.4	8.4e-08	-0.08	0.43	0.06	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	3.9	-5.3	8.9e-08	0.64	0.67	0.08	FALSE
42	GTEx	Whole Blood	UBXN2A	0.17	0.07	lasso	8	0.09	2.1e-08	-1.2	-5.3	9.4e-08	-0.08	0.04	0.96	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC4A1AP	0.02	0.03	lasso	2	0.03	3.7e-04	-1.5	5.3	1.0e-07	-0.47	0.01	0.83	FALSE
45	METSIM	Adipose	PREB	0.04	0.01	bslmm	302	0.02	5.6e-04	2.6	5.3	1.1e-07	-0.36	0.07	0.30	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	-5.7	-5.3	1.2e-07	0.08	0.11	0.07	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCOA1	0.08	0.07	blup	77	0.05	5.8e-04	3.4	-5.3	1.2e-07	-0.02	0.10	0.65	FALSE
52	YFS	Blood	MRPL33	0.02	0.01	blup	385	0.01	6.4e-05	5.7	-5.2	1.6e-07	0.22	0.97	0.00	FALSE
46	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	-6.4	-5.2	1.8e-07	0.00	0.87	0.13	FALSE
10	GTEx	Breast Mammary Tissue (Male)	NCOA1	0.13	-0.01	lasso	3	0.04	4.8e-02	-3.9	-5.2	2.0e-07	0.09	0.05	0.06	FALSE
51	YFS	Blood	EIF2B4	0.01	0.00	enet	9	0.00	8.5e-02	2.1	5.2	2.0e-07	-0.52	0.04	0.03	FALSE
5	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	4.7	-5.2	2.3e-07	0.64	0.11	0.28	FALSE
7	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	5.2	-5.2	2.4e-07	0.58	0.24	0.14	FALSE
31	GTEx	Nerve Tibial	NCOA1	0.13	0.02	enet	15	0.07	8.9e-06	-3.5	-5.2	2.6e-07	0.03	0.83	0.01	FALSE
68	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SLC4A1AP	0.17	0.05	blup	26	0.08	4.4e-03	-9.7	5.1	3.0e-07	-0.47	0.01	0.72	FALSE