TWAS hub - PREB

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0366	0.0204	3.6e-03	0.009	0.018	0.002	0.019	0.005	1.2e-02	8.7e-04	1.2e-01	5.6e-04	4.9e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.3659	0.0603	2.3e-14	0.220	0.166	0.219	0.218	0.216	8.0e-28	7.9e-21	1.3e-27	1.7e-27	3.0e-27
3	TCGA	Breast Invasive Carcinoma	0.0360	0.0189	1.0e-04	0.022	0.024	0.026	NA	0.021	1.6e-05	9.2e-06	4.1e-06	NA	2.7e-05
4	TCGA	Cervical Squamous Cell Carcinoma	0.1850	0.0920	8.4e-03	0.013	0.019	0.005	NA	0.009	7.4e-02	3.9e-02	1.8e-01	NA	1.1e-01
5	TCGA	Esophageal Carcinoma	0.2730	0.1220	7.6e-03	0.056	0.038	0.031	NA	0.058	7.3e-03	2.3e-02	3.8e-02	NA	6.5e-03
6	TCGA	Pheochromocytoma and Paraganglioma	0.1200	0.0570	5.9e-05	0.081	0.120	0.105	NA	0.101	4.1e-04	1.8e-05	5.8e-05	NA	7.9e-05
7	TCGA	Prostate Adenocarcinoma	0.0672	0.0349	2.4e-04	0.051	0.043	0.029	NA	0.046	4.7e-06	2.3e-05	4.7e-04	NA	1.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Triglycerides	11.1	18.2	65.6	-8.1	-2.9	-5.6	-0.8	-4.0	-2.3	0.0
Diabetes diagnosed by doctor	6.7	11.0	26.8	5.2	3.4	3.5	1.1	2.0	3.3	3.2
Diabetes (self-reported)	6.4	9.9	23.5	4.8	3.2	3.3	1.3	2.2	3.1	2.9
Risk taking	5.4	8.0	20.2	2.5	2.8	2.9	-1.8	0.1	4.5	3.1
Medication: Amlodipine	5.0	6.9	9.0	1.8	2.1	3.0	2.9	2.9	3.0	2.6
Type 2 Diabetes (T2D) (2018)	4.1	7.7	26.8	5.2	2.5	2.4	0.1	1.6	2.7	2.2
High cholesterol (Self-reported)	4.1	7.2	17.4	-4.2	-2.9	-3.6	-0.7	-2.6	-1.0	-1.9
Hearing aid user	4.0	4.5	8.0	-2.8	-2.4	-1.4	-0.9	-1.7	-2.3	-2.5
Medication: Metformin	3.8	5.4	14.3	3.8	2.4	2.3	-0.8	0.3	2.6	2.3
Pain type(s) experienced in last month: Hip pain	3.6	4.5	8.2	2.0	2.7	2.3	0.5	0.5	2.5	2.9
Osteoarthritis (self-reported)	3.3	4.3	7.0	1.9	2.2	2.0	1.8	1.7	2.6	2.3
Pulse rate, automated reading	3.1	10.0	24.0	-4.9	-2.9	-3.7	-1.7	-3.0	-2.1	-2.8
Hearing difficulty/problems with background noise	3.0	4.8	7.8	-1.6	1.2	2.8	2.7	2.8	2.2	1.4
Ever used hormone-replacement therapy (HRT)	2.9	3.7	11.6	3.4	1.3	2.4	-0.2	0.0	2.2	1.4
Number of children fathered	2.9	3.3	5.3	1.5	2.3	2.3	0.5	0.2	2.1	2.3
Medication for hormone replacement therapy	2.8	3.1	7.6	1.9	1.8	1.9	-0.4	-0.1	2.8	1.9
Medication for pain relief, constipation, heartburn	2.8	4.7	7.7	-0.1	-1.9	-1.8	-2.8	-2.5	-2.3	-2.6
Gout (self-reported)	2.7	3.7	21.8	-4.7	0.0	-0.8	1.8	-0.2	-0.1	0.4
Unable to work because of sickness or disability	2.7	3.5	8.0	2.8	1.8	1.5	-1.0	-0.7	2.4	1.9
Heart attack/myocardial infarction (self-reported)	2.6	3.3	8.0	0.1	1.8	2.5	0.6	0.9	2.8	2.0
Pulse rate	2.5	4.2	8.9	-3.0	-1.6	-2.2	-1.4	-2.6	-1.4	-1.5
Medication: Allopurinol	2.5	3.4	18.9	-4.3	-0.3	-0.6	2.0	0.1	-0.6	0.0
Taking other prescription medications	2.4	3.7	6.4	-1.4	1.8	2.5	2.0	1.2	2.0	2.1
Heart attack	2.4	3.1	6.9	-0.0	1.7	2.5	0.9	1.0	2.6	1.9
Pack years of smoking	2.4	3.5	6.9	0.6	-2.6	-1.8	-1.5	-1.6	-1.7	-2.4
Pack years adult smoking proportion	2.3	3.5	6.1	0.6	-2.5	-2.0	-1.9	-1.8	-1.6	-2.2
Commuting to job workplace: Walk	2.3	2.5	6.1	-0.3	-2.5	-1.4	0.8	-0.0	-2.0	-2.2
Medication: Ramipril	2.2	2.9	6.2	0.1	1.2	2.1	2.5	1.7	1.7	1.5
Pulse wave Arterial Stiffness index	2.2	2.6	5.9	0.2	2.2	1.7	0.8	0.6	1.9	2.4
Number of treatments/medications taken	2.1	3.8	7.4	-0.2	1.6	1.5	2.7	1.6	2.2	2.6
Hayfever, allergic rhinitis or eczema	2.1	4.6	15.0	-3.9	-1.5	-1.0	2.0	1.1	-2.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	6.9	1.6	0.6	0.4	-2.6	-2.4	1.3	1.0
Primary Biliary Cirrhosis	2.0	2.9	5.8	-1.8	1.6	2.4	0.4	0.5	2.3	1.7
Had menopause	2.0	2.5	7.8	2.8	0.4	2.6	-0.7	-0.1	1.5	0.6
Pulse wave reflection index	2.0	2.5	4.3	2.1	1.8	1.4	0.1	0.6	1.9	1.9
Medication: Blood pressure	2.0	3.8	10.9	0.5	0.5	1.7	2.8	3.3	1.9	1.1
Blood White Count	1.9	14.4	44.4	-6.7	-2.0	-5.2	1.7	-2.0	-3.9	-1.9
LDL Cholesterol	1.8	2.8	6.2	-1.9	-1.9	-2.4	-0.2	-0.6	-2.5	0.0
Chronotype (morning person)	1.8	4.1	9.4	0.7	-1.9	-2.9	-0.2	-1.3	-3.1	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	6.0	1.1	2.2	2.4	2.2	2.4	1.5	2.1
Pulse wave peak to peak time	1.8	2.1	4.9	0.2	-2.0	-1.4	-0.9	-0.6	-1.7	-2.2
Medication: Aspirin	1.8	2.3	3.8	0.6	1.2	1.5	2.0	1.9	1.6	1.5
HbA1C	1.7	1.8	3.1	1.0	1.6	1.8	1.5	1.4	1.4	0.0
Impedance of leg (left)	1.7	8.4	16.2	-2.4	-2.2	-4.0	-3.1	-3.5	-1.8	-2.5
Waist circumference	1.7	6.1	12.5	3.5	1.5	3.1	-0.6	0.7	3.5	2.2
Hip circumference	1.7	7.2	15.1	3.9	1.6	3.1	1.2	2.8	3.1	2.1
Time employed in main current job	1.7	2.0	4.3	-1.4	1.1	2.0	2.1	1.0	0.8	1.1
Birth weight of first child	1.7	3.1	4.4	2.0	-1.4	-1.8	-2.1	-2.0	-1.3	-1.6
Knee pain experienced in last month	1.7	2.6	5.7	1.7	1.6	1.6	0.1	0.9	2.4	1.9
Hypertension (Self-reported)	1.7	4.8	12.2	-0.4	0.1	2.3	3.3	3.5	1.9	1.3
Financial situation satisfaction	1.7	2.2	4.7	0.9	1.1	1.3	2.2	2.2	1.0	1.1
Vascular/heart problems diagnosed by doctor	1.6	4.3	8.7	0.5	-0.2	-2.4	-2.7	-2.9	-2.5	-1.4
Age at First Birth	1.5	2.2	7.0	-1.5	-1.1	-1.8	0.8	-0.9	-2.6	0.0
Leg pain on walking	1.5	1.9	3.7	1.9	1.7	1.3	-0.1	-0.0	1.6	1.6
Medication for cholesterol	1.5	2.3	4.6	-0.3	-0.8	-1.2	-2.1	-1.6	-2.2	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	5.5	1.5	1.1	0.3	-0.2	0.6	2.3	1.6
Medication: Atorvastatin	1.5	1.8	5.7	-2.4	-1.2	-1.4	-1.1	-1.3	0.6	-0.7
Schizophrenia (2018)	1.4	2.8	12.2	1.2	-0.1	0.9	-3.5	-1.5	1.7	0.0
Reaction Time	1.4	2.6	8.4	-2.9	-1.8	0.3	1.4	1.3	-0.5	-1.6
Schizophrenia (2014)	1.4	3.1	14.4	1.5	-0.2	0.3	-3.8	-1.7	1.5	0.0
Systolic blood pressure, automated reading	1.4	4.0	13.1	-1.9	0.5	1.4	3.6	2.8	0.4	1.2
Impedance of leg (right)	1.4	6.8	14.8	-2.1	-2.0	-3.9	-2.5	-3.0	-1.8	-2.4
Leg fat-free mass (left)	1.4	7.6	22.1	4.7	1.4	4.0	0.3	2.0	2.4	1.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.3	0.3	1.1	1.6	-1.1	-1.0	1.8	1.2
Leg predicted mass (left)	1.4	7.5	21.5	4.6	1.4	4.0	0.3	2.0	2.4	1.8
Weight	1.4	7.1	18.5	4.3	1.4	3.5	-0.2	1.8	3.0	2.0
Medication: Lansoprazole	1.4	1.6	3.5	1.1	1.3	1.1	0.4	-0.4	1.9	1.7
Arm fat-free mass (right)	1.4	7.2	30.8	5.5	1.6	3.2	-1.0	0.3	1.6	1.7
Arm predicted mass (right)	1.4	7.1	30.0	5.5	1.6	3.3	-0.7	0.6	1.6	1.7
Leg fat-free mass (right)	1.4	7.5	20.2	4.5	1.5	4.0	0.2	2.0	2.4	1.9
Leg predicted mass (right)	1.4	7.5	20.2	4.5	1.5	4.1	0.1	2.0	2.5	1.9
Bipolar Disorder or Schizophrenia	1.3	3.1	13.6	0.8	1.0	0.6	-3.7	-1.7	1.8	0.0
Prostate Cancer	1.3	1.8	2.4	1.6	1.5	0.9	-1.2	-1.6	1.3	1.3
Waist Hip Ratio (WHR)	1.3	5.8	17.8	0.1	0.4	0.5	-4.2	-4.2	2.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	4.0	0.4	1.4	1.3	0.9	1.6	2.0	1.7
Medication: Blood pressure	1.3	2.3	5.0	0.3	0.8	1.8	2.2	1.7	1.4	1.5
Mean time to correctly identify matches	1.3	2.5	7.7	-2.8	-1.1	0.9	2.1	1.4	-0.2	-1.1
Medication: Aspirin	1.3	1.7	4.1	0.3	0.9	1.5	2.0	1.4	1.2	1.1
Arm fat-free mass (left)	1.3	6.4	28.2	5.3	1.5	3.1	-0.5	0.5	1.4	1.6
Arm predicted mass (left)	1.3	6.6	29.4	5.4	1.4	3.0	-0.6	0.4	1.5	1.6
Crohns Disease (2017)	1.2	2.5	13.9	-3.7	-1.0	-1.2	0.3	-0.1	-0.1	-1.1
Ovarian Cancer	1.2	1.6	3.7	-1.0	1.9	1.1	1.2	0.6	0.5	1.8
Angina	1.2	1.6	4.0	-0.9	1.1	1.5	0.7	0.8	2.0	1.4
High blood pressure	1.2	3.3	8.6	-0.5	-0.2	1.8	2.6	2.9	1.8	1.0
Trunk fat mass	1.2	5.1	11.7	3.1	0.9	2.9	-0.8	1.2	3.4	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	3.3	0.0	1.6	0.8	1.4	1.1	1.1	1.8
Lung cancer (father)	1.2	1.5	4.6	-0.9	-1.0	-1.1	-2.1	-1.2	-0.1	-1.1
Glaucoma (self-reported)	1.2	1.4	4.7	0.7	-0.5	-1.3	-1.4	-2.2	-0.8	-0.6
Alcohol intake frequency.	1.2	2.8	7.6	-2.8	-1.3	-2.7	0.1	-1.6	0.2	-0.8
Whole body fat-free mass	1.2	6.6	27.1	5.2	1.2	3.5	-0.3	1.1	1.5	1.4
Long-standing illness, disability or infirmity	1.2	1.9	3.4	1.0	1.5	1.5	1.2	0.7	1.6	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.5	-0.4	-0.8	-1.6	-1.1	-1.9	-0.8	-0.7
Eye problems/disorders: Cataract	1.2	1.4	7.0	-0.8	0.9	0.2	2.6	0.8	0.5	0.7
Illnesses of father: None of the above (group 1)	1.2	1.5	4.4	0.1	0.9	1.0	1.8	2.1	0.8	0.6
Whole body water mass	1.2	6.9	29.3	5.4	1.3	3.4	-0.4	1.1	1.5	1.5
Wears glasses or contact lenses	1.2	1.4	2.3	0.2	1.5	1.3	0.9	0.7	1.5	1.5
Medication: Paracetamol	1.2	1.8	4.7	0.1	1.6	1.1	0.6	0.1	2.0	2.2
Basal metabolic rate	1.2	6.8	25.7	5.1	1.3	3.5	-0.3	1.4	1.9	1.6
Systolic Blood Pressure	1.1	5.4	16.2	-1.5	1.0	1.4	4.0	3.2	1.0	2.3
Allergy or Eczema	1.1	3.0	12.5	-3.5	-0.4	-0.1	2.2	1.1	-1.3	-0.7
Diabetes (father)	1.1	1.3	2.9	1.7	-1.2	-0.9	-0.4	-0.2	-1.5	-1.3
Illnesses of siblings	1.1	1.5	4.0	1.4	0.0	-0.5	-2.0	-1.8	-0.8	-0.6
Father’s age at death	1.1	1.5	4.4	-2.1	-1.4	-0.3	0.0	-0.1	-0.9	-1.8
Worrier / anxious feelings	1.1	2.1	7.0	-2.6	-1.5	-0.0	0.8	-1.0	-1.4	-1.3
Medication: Cholesterol lowering	1.1	1.6	5.9	-2.4	-1.1	-1.2	-0.4	-1.6	0.3	-0.5
Medication: Lisinopril	1.1	1.4	2.2	0.7	1.1	1.4	0.8	1.0	1.5	1.4
Fractured/broken bones in last 5 years	1.1	1.4	2.2	-0.2	0.9	1.4	1.1	1.2	1.5	1.4
Fasting Glucose	1.0	1.2	4.6	1.5	-0.2	0.1	1.1	0.8	-2.1	0.0
Trunk fat percentage	1.0	4.1	13.4	1.8	0.9	2.4	-0.6	1.2	3.7	1.8
Maternal smoking around birth	1.0	1.4	2.9	-0.4	1.2	1.7	-0.8	0.3	1.7	1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.9	-0.6	1.1	0.7	2.0	0.4	0.6	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.6	-1.9	-0.3	-0.8	0.4	-0.9	-1.7	-0.3
Body mass index (BMI)	1.0	4.1	6.4	2.5	1.3	2.4	1.0	2.0	2.4	2.0
Pain all over the body in last month	1.0	1.1	3.0	-0.6	0.6	1.5	0.8	0.6	1.7	1.0
Trunk fat-free mass	1.0	5.5	28.6	5.3	0.9	2.7	-0.6	0.5	0.7	1.0
Trunk predicted mass	1.0	5.8	29.5	5.4	1.0	2.8	-0.6	0.5	0.8	1.1
Exposure to tobacco smoke at home	1.0	1.2	1.9	0.8	1.1	0.9	1.1	1.2	1.4	1.1
Worry too long after embarrassment	1.0	1.7	3.7	-1.1	-1.0	-1.0	1.9	0.9	-1.8	-1.0
Health satisfaction	1.0	1.3	2.7	-1.2	-1.6	-1.1	-0.7	-1.2	-0.4	-1.2
Angina (self-reported)	1.0	1.4	3.5	-0.7	1.0	1.4	0.4	0.5	1.9	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.3	-2.1	-0.5	-0.7	-0.8	-1.3	-0.9	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	6.0	-0.7	-0.4	-0.8	-1.1	-2.5	-0.2	-0.1
Ever had bowel cancer screening	1.0	1.2	2.9	-1.7	-0.5	-0.3	-1.6	-1.5	-0.0	-0.4
Friendships satisfaction	1.0	1.2	3.0	0.0	-0.6	-1.7	-0.4	-1.2	-1.7	-0.8
Smoking status: Current	1.0	1.6	3.6	-0.5	-1.5	-0.9	-1.9	-1.5	-0.5	-1.3
Number of self-reported non-cancer illnesses	1.0	1.7	5.0	-2.2	-0.1	0.6	2.2	1.1	0.8	0.5
Pain experienced in last month	1.0	1.6	4.9	-0.2	-1.0	-1.1	0.6	0.5	-2.2	-1.9
Medication: Co-codamol	0.9	1.1	3.1	1.5	-0.1	-1.0	-1.0	-1.8	-0.3	0.2
Current tobacco smoking	0.9	1.5	2.8	-0.6	-1.7	-0.9	-1.6	-1.2	-0.5	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.8	1.2	1.5	1.9	1.1	1.5	0.8	1.4
Allergy	0.9	2.2	7.7	2.8	1.1	0.9	-0.6	-0.0	1.9	1.3
Qualifications: A levels/AS levels or equivalent	0.9	1.9	6.0	-2.5	1.1	1.1	1.9	0.5	-0.8	0.6
Arm fat mass (right)	0.9	3.6	7.6	2.8	0.7	2.5	0.1	1.7	2.4	1.4
Medication: Paracetamol	0.9	1.5	3.6	-0.1	1.2	1.0	1.0	0.6	1.6	1.9
Whole body fat mass	0.9	3.5	7.8	2.7	0.6	2.4	-0.6	1.1	2.8	1.3
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-0.5	0.3	1.4	1.5	1.4	0.9	0.3
Mineral and other dietary supplements	0.9	1.2	2.7	-0.9	0.5	1.1	1.6	1.6	0.6	0.5
Arm fat mass (left)	0.9	3.8	8.4	2.9	0.9	2.5	-0.0	1.6	2.6	1.6
Ever taken oral contraceptive pill	0.9	1.0	2.3	-0.3	1.5	1.5	-0.3	-0.2	0.8	1.2
Impedance of whole body	0.9	4.8	9.9	-3.1	-1.9	-2.8	-2.2	-1.9	-0.4	-1.9
Coronary Artery Disease (CAD)	0.8	0.9	3.0	-1.7	-1.5	-0.6	-0.3	0.8	-0.4	0.0
HDL Cholesterol	0.8	1.4	5.7	2.4	-0.8	-0.6	-1.6	-0.4	0.5	0.0
Heel T-Score	0.8	6.2	11.3	1.3	2.9	3.4	0.6	2.0	3.0	2.9
Average weekly spirits intake	0.8	1.0	2.7	1.6	0.7	-0.2	-0.5	-0.2	1.6	0.8
Average weekly fortified wine intake	0.8	1.0	2.5	-0.0	-1.2	-1.3	0.2	0.0	-1.6	-1.1
Age when periods started (menarche)	0.8	1.9	5.3	2.3	-0.1	-0.8	-2.1	-1.8	0.1	0.1
Mouth/teeth dental problems: Dentures	0.8	1.4	5.6	2.4	1.1	0.6	1.3	0.1	-0.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.0	-1.7	-0.0	-0.1	1.6	0.7	-1.6	-0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.1	1.1	-0.3	-1.0	-2.0	-0.9	-1.1	-0.9
Number of full brothers	0.8	1.0	2.7	1.5	-0.2	-0.8	-1.1	-1.6	-0.1	-0.2
Heart disease (mother)	0.8	1.0	2.1	-0.8	-0.9	-1.3	-0.6	-1.4	-0.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.7	-0.8	0.7	0.9	1.3	1.6	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.1	0.8	-1.1	-0.6	-2.0	-1.8	-0.9	-1.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.7	0.1	-1.1	-1.3	-1.0	-0.1	-1.0	-1.3
Illnesses of father: High blood pressure	0.8	1.0	3.2	-1.1	-1.8	-0.8	-0.4	-0.1	-1.0	-1.1
Age started oral contraceptive pill	0.8	1.0	2.1	-1.4	-0.9	-0.7	-0.2	-1.2	-1.1	-1.1
Diastolic blood pressure, automated reading	0.8	2.6	7.8	-0.3	0.5	1.4	2.8	2.6	0.2	1.1
Depressed Affect (Nagel 2018)	0.7	1.6	3.0	0.8	1.1	1.0	1.3	0.8	1.7	1.7
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	-0.8	-1.4	-1.0	-1.0	-0.2	-0.8	-1.4
Irritable Bowel Disease (IBD)	0.7	1.7	9.2	-3.0	-0.2	-0.3	1.1	0.9	0.7	-0.3
Ulcerative Colitis (UC)	0.7	1.3	2.6	-1.2	0.8	0.6	1.6	1.5	1.2	0.8
Bipolar Disorder (2011)	0.7	0.7	1.7	-0.9	0.0	0.1	-1.3	-0.9	1.2	0.0
Ulcerative Colitis	0.7	1.0	3.5	-1.9	0.7	1.0	-0.0	0.4	1.3	0.0
Blood Platelet Count	0.7	8.5	32.5	-5.7	-0.9	-4.8	0.5	-1.8	0.1	-0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	1.0	0.6	0.7	1.1	1.4	0.7	0.6
Supplements: Zinc	0.7	0.8	1.3	-0.3	-1.1	-0.8	-0.9	-0.1	-1.1	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.2	-0.8	0.9	1.1	1.5	1.1	0.8	0.6
Impedance of arm (right)	0.7	3.1	12.0	-3.5	-1.8	-1.6	-0.8	-0.3	0.1	-1.6
Alcohol intake versus 10 years previously	0.7	1.0	5.7	-2.4	-0.3	0.3	0.8	-0.5	0.6	-0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.8	-0.5	0.8	0.3	-0.1	-1.3	1.2	1.4
Body fat percentage	0.7	2.6	8.9	1.5	0.6	1.9	-0.5	1.0	3.0	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.5	0.5	1.6	0.8	0.8	-0.0	0.1	1.4
Leg fat mass (right)	0.7	2.7	7.5	2.7	0.5	2.0	-0.2	1.0	2.2	1.1
Arm fat percentage (left)	0.7	2.7	7.2	1.4	0.7	2.0	0.3	1.8	2.7	1.5
Osteoporosis (self-reported)	0.7	0.9	2.7	-1.6	0.8	0.8	0.3	-0.3	0.9	1.1
Medication: Gliclazide	0.7	0.8	2.0	1.4	-0.3	-0.0	-1.4	-1.1	0.0	-0.5
Medication: Bendroflumethiazide	0.7	1.1	3.0	1.5	-0.6	0.0	1.7	1.5	0.2	-0.0
Leg fat mass (left)	0.7	2.6	7.2	2.7	0.5	2.0	-0.5	0.8	2.1	1.1
Bipolar Disorder (2018)	0.6	1.0	3.0	-0.3	1.7	-0.3	-1.6	-0.8	0.8	0.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	8.1	0.4	-0.5	-1.2	1.4	0.5	-2.8	-0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.8	0.7	-1.7	0.9	-1.2	0.2	0.5	0.0
Verbal and Numeric Reasoning (VNR)	0.6	1.5	4.3	1.2	0.1	-0.9	1.6	1.0	-2.1	-0.2
Lupus	0.6	0.9	3.7	-1.9	0.5	0.4	1.3	0.6	0.2	0.5
Rheumatoid Arthritis	0.6	0.9	3.3	-0.6	-1.8	-0.9	-0.5	0.0	-1.2	0.0
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	-1.2	-1.1	-1.1	-0.0	0.1	-0.7	-1.1
Hearing difficulty/problems: Yes	0.6	0.9	4.3	-2.1	0.1	0.8	0.8	0.8	0.4	0.1
Townsend deprivation index at recruitment	0.6	0.8	1.5	0.3	-1.2	-0.6	-1.0	-0.8	-0.7	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.7	0.1	1.1	0.3	0.4	-0.7	1.2	1.3
Supplements: Glucosamine	0.6	0.8	1.6	1.3	0.7	-0.3	-1.2	-1.2	0.1	0.7
Medication: Atenolol	0.6	0.7	2.1	0.8	0.1	0.6	1.3	1.4	0.4	0.4
Medication: Levothyroxine sodium	0.6	1.0	4.8	-0.6	0.1	0.1	2.2	1.3	-0.7	0.1
Fluid intelligence score	0.6	1.3	3.6	1.6	0.2	-0.8	1.4	0.7	-1.9	-0.2
Falls in the last year	0.6	0.8	2.8	0.5	1.1	0.5	0.3	-0.2	1.7	1.2
Hair/balding pattern: Pattern 3	0.6	0.8	2.0	1.4	0.4	1.2	0.9	0.9	0.7	0.3
Impedance of arm (left)	0.6	2.8	10.7	-3.3	-1.4	-1.4	-1.5	-0.6	0.6	-1.3
High blood pressure (siblings)	0.6	0.8	2.6	-0.8	-1.6	-0.9	0.6	0.8	-0.1	-0.8
Age at first live birth	0.6	1.1	4.2	-2.1	0.2	-0.5	0.8	-0.8	-1.3	-0.3
Shortness of breath walking on level ground	0.6	0.7	1.4	1.1	0.6	1.1	-0.2	-0.2	1.2	0.8
Eye problems/disorders: None of the above	0.6	0.7	1.9	0.1	0.2	1.1	-0.8	1.4	0.9	0.3
Illnesses of father: Heart disease	0.6	0.9	3.1	-0.5	-0.7	-1.2	-0.5	-1.8	-0.5	-0.5
Eye problems/disorders: Glaucoma	0.6	0.7	2.9	0.3	0.2	-0.8	-1.0	-1.7	-0.5	0.1
Average weekly beer plus cider intake	0.6	0.9	4.1	0.5	-0.0	0.5	-2.0	-0.6	1.1	0.1
Cholesterol lowering medication	0.6	0.9	4.3	-2.1	-0.6	-1.2	0.3	-0.6	0.2	-0.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-1.0	-0.5	-0.3	1.0	1.2	-0.4	-0.4
Major Depression (MDD)	0.5	0.6	2.1	1.4	-0.2	-0.2	-1.1	-0.0	0.8	0.0
Cardiovascular Disease	0.5	1.7	3.6	-1.8	-1.1	0.3	1.5	1.9	1.2	0.4
Hypothyroidism (self reported)	0.5	1.2	3.6	-1.2	-0.3	0.1	1.9	1.5	-1.1	-0.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	-0.6	1.0	0.7	0.4	-0.6	0.8	0.8
Diabetes (mother)	0.5	0.7	2.1	0.3	-0.4	1.4	0.6	1.3	0.5	-0.1
Relative age voice broke	0.5	0.8	3.2	-1.8	0.6	0.9	0.6	0.1	0.3	0.7
Number of incorrect matches in round	0.5	0.9	3.1	0.5	0.7	0.6	-0.2	1.3	1.8	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.5	-1.2	0.4	0.9	1.2	0.7	0.6	0.5
Financial difficulties in last 2 years	0.5	0.7	1.1	0.9	0.4	0.9	-0.8	-1.0	0.9	0.8
Arm fat percentage (right)	0.5	2.0	4.8	1.2	0.3	1.7	0.5	1.8	2.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.2	0.2	-0.8	-1.5	-0.1	-0.1	-0.5	-0.8
Standing height	0.5	4.8	18.9	4.3	0.1	2.3	-2.7	-0.4	1.5	0.1
Length of working week for main job	0.5	0.5	2.2	1.5	0.4	0.2	0.4	0.9	0.2	0.0
Headache pain in last month	0.5	0.8	1.5	-1.2	-0.9	-1.2	0.7	0.7	-0.9	-0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.5	-1.9	0.3	0.9	0.3	0.1	0.2	0.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	0.1	0.9	0.8	1.1	0.7	0.8	1.0
Comparative body size at age 10	0.5	1.4	3.5	-0.6	0.8	0.6	1.9	1.9	0.8	1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	-0.2	-0.3	-0.0	1.3	1.3	0.4	-0.2
Medication: Ibuprofen	0.5	0.6	1.4	0.3	1.0	0.1	1.0	0.7	0.5	1.2
Comparative height size at age 10	0.5	2.9	12.3	3.5	0.2	2.0	-1.1	1.1	1.2	0.1
Overall health rating	0.5	1.1	4.1	-0.6	0.3	0.1	-1.0	-1.3	2.0	0.8
Had major operations	0.5	0.6	3.1	-0.3	0.4	0.5	1.8	0.3	0.3	0.8
Family relationship satisfaction	0.5	0.6	1.7	1.2	-0.2	-0.1	-1.3	-0.7	0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	0.2	1.1	0.6	0.5	-0.3	1.2	0.9
Average weekly red wine intake	0.5	0.7	2.8	-0.6	0.8	1.7	0.5	0.2	0.3	0.8
Average weekly champagne plus white wine intake	0.5	0.8	1.7	0.1	1.0	1.2	0.5	1.3	0.4	0.9
Mother’s age at death	0.5	0.7	2.2	-0.5	-0.7	0.3	-1.5	-0.7	0.1	-1.0
Number of operations (self-reported)	0.5	0.8	2.5	-0.6	0.6	1.0	1.6	-0.7	-0.1	0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.1	-0.2	1.0	0.7	0.4	0.7	1.1	1.0
Heart disease (siblings)	0.5	0.6	1.6	-1.1	-0.7	-1.3	-0.2	-0.8	-0.3	-0.4
Body Mass Index (BMI) (2010)	0.4	0.5	2.0	1.4	-0.8	-0.4	-1.0	-0.1	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	-0.2	0.6	1.0	0.4	1.0	1.0	0.0
BMI	0.4	2.5	6.2	2.5	0.2	1.8	0.4	2.2	1.4	0.9
Height	0.4	7.8	29.9	5.5	0.1	2.8	-3.5	-1.4	1.6	0.2
Relative age of first facial hair	0.4	0.9	2.3	-1.5	-0.9	-1.1	-0.3	-0.4	-0.4	-1.1
Stomach or abdominal pain in last month	0.4	0.4	1.6	0.4	-0.3	-1.3	-0.8	-0.5	0.6	0.1
Sitting height	0.4	3.0	16.0	4.0	0.5	1.9	-0.8	0.8	0.2	0.5
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	-0.3	0.6	0.4	-0.7	0.2	1.2	0.8
High blood pressure (mother)	0.4	0.5	2.3	0.1	0.3	-0.3	1.5	1.0	-0.1	0.5
Alcohol usually taken with meals	0.4	0.7	3.3	-1.8	-0.4	0.1	0.8	0.3	-0.4	-0.4
Had other major operations	0.4	0.5	1.5	1.0	-0.3	-0.8	-0.5	-1.2	-0.2	-0.3
Mouth/teeth dental problems	0.4	0.6	1.6	-1.2	-0.2	0.8	-0.2	1.3	0.3	-0.2
Medication: Simvastatin	0.4	0.5	1.0	-1.0	-0.8	-1.0	-0.1	-1.0	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	1.3	0.1	-0.4	1.0	0.5	-0.2	0.1
Loud music exposure frequency	0.4	0.5	1.8	0.2	-0.5	0.5	-1.4	-0.1	0.7	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.1	0.1	0.4	0.4	1.8	1.5	0.1	0.5
Exposure to tobacco smoke outside home	0.4	0.6	1.6	1.3	-0.5	-1.2	-0.1	0.2	-0.7	-0.4
Migraine (self-reported)	0.4	0.5	1.5	1.0	0.5	0.1	-0.2	-1.2	0.2	0.7
Medication: Omeprazole	0.4	0.5	1.3	0.1	-0.8	-0.6	-1.1	-1.1	0.1	-0.3
Number of full sisters	0.4	0.5	2.7	-1.6	-0.1	0.2	-0.3	-0.8	-0.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	-0.4	-0.6	-1.0	-0.1	-1.1	-0.6	-0.4
Loneliness, isolation	0.4	0.5	1.4	-0.8	-0.6	-1.2	-0.0	-0.8	-0.4	-0.7
Miserableness	0.4	0.7	2.6	-0.2	0.6	-0.3	1.6	0.8	-0.3	0.9
Guilty feelings	0.4	0.6	2.2	1.5	0.7	-0.6	-0.6	-0.3	0.5	0.8
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.7	-0.4	-0.9	0.2	0.2	-1.2	-0.6
Alcohol drinker status: Never	0.4	0.5	0.9	0.9	0.4	-1.0	-0.8	-0.5	0.8	0.7
Myopia	0.4	0.6	2.1	1.4	-0.0	-0.3	-0.9	0.0	1.0	0.3
Supplements: Calcium	0.4	0.4	2.2	0.5	0.3	-0.3	-0.5	-1.5	-0.1	0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.5	-0.4	-0.3	-0.6	-0.0	-1.2	-1.0	-0.4
Depression (Nagel 2018)	0.3	0.5	1.0	-0.2	-1.0	-1.0	0.4	0.9	-0.1	-0.8
Neuroticism (2016)	0.3	0.4	2.3	1.5	-0.0	-0.3	0.1	0.3	0.3	0.2
Blood Red Count	0.3	2.6	8.2	0.1	2.0	0.3	2.9	1.7	-1.2	1.2
Lung FEV1/FVC ratio	0.3	1.6	5.7	0.7	-0.3	-1.3	-1.2	-2.4	-1.2	-0.4
Neuroticism	0.3	0.7	1.5	-0.3	-1.1	-1.2	1.0	-0.3	-0.5	-0.9
Sensitivity / hurt feelings	0.3	0.6	1.3	1.2	0.6	0.4	0.3	0.6	1.0	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.5	0.9	0.2	-1.2	-0.1	-0.3	-0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	1.1	-0.1	-0.4	-0.9	-0.7	0.5	0.1
Qualifications: None of the above	0.3	0.6	2.0	0.9	-0.5	0.1	-1.4	-0.2	1.1	-0.2
Asthma	0.3	0.5	1.2	-0.8	-0.7	-0.0	-0.9	-1.1	-0.2	-0.7
Depression (self-reported)	0.3	0.3	0.6	0.6	0.8	0.1	0.4	-0.6	0.5	0.6
Prospective memory result	0.3	0.4	1.4	-0.2	-1.2	0.1	-0.4	0.4	0.2	-1.1
Illnesses of mother	0.3	0.4	1.3	-0.6	0.8	1.1	-0.2	-0.1	0.5	0.5
Breastfed as a baby	0.3	0.4	0.7	0.8	-0.8	-0.8	-0.2	-0.3	-0.6	-0.8
Tense / ‘highly strung’	0.3	0.5	1.8	-0.4	-0.4	-0.5	-0.9	-1.3	0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	1.3	0.6	-0.2	-0.1	0.4	0.9	0.6
Peak expiratory flow (PEF)	0.3	0.6	2.2	-0.2	0.6	-0.2	-1.5	-1.0	0.5	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.1	0.2	0.6	0.5	-0.0	-1.1	-0.2	0.8
Leg fat percentage (right)	0.3	1.0	3.0	1.4	0.2	0.8	-0.1	0.6	1.7	0.9
Suffer from ‘nerves’	0.3	0.4	2.3	0.2	-0.2	-0.0	1.5	0.4	-0.7	-0.1
Smoking status: Previous	0.3	0.4	1.0	-1.0	0.1	0.9	0.4	1.0	0.4	0.1
Back pain experienced in last month	0.3	0.5	1.7	-0.6	-0.0	0.2	-1.1	-1.3	0.1	0.3
Breast cancer (self-reported)	0.3	0.4	1.3	-0.9	-0.3	0.4	0.1	-1.1	-0.5	-0.3
Asthma (self-reported)	0.3	0.6	1.1	-0.8	-0.8	-0.2	-0.9	-1.0	-0.3	-0.7
Leg fat percentage (left)	0.3	1.1	3.6	1.3	0.4	1.0	-0.4	0.3	1.9	1.0
Ever depressed for a whole week	0.3	0.3	1.1	1.1	0.0	-0.5	-0.8	-0.6	-0.3	-0.1
Alcohol drinker status: Previous	0.3	0.4	0.9	-0.2	0.8	0.6	0.3	0.0	0.8	1.0
Worry (Nagel 2018)	0.2	0.5	2.5	-0.4	-0.6	0.1	-0.0	-1.6	0.0	-0.4
Crohns Disease (2012)	0.2	0.3	1.6	-1.3	-0.4	-0.5	-0.3	-0.1	0.0	0.0
Mean Putamen Volume	0.2	0.2	0.7	-0.8	0.1	0.4	0.7	0.6	0.0	0.0
Blood Eosinophil Count	0.2	1.3	3.6	0.6	0.7	-0.3	1.9	1.9	-0.6	0.7
Lung FVC	0.2	0.9	4.8	-2.2	-0.1	-0.8	0.6	0.1	-0.7	-0.1
Hand grip strength (left)	0.2	0.5	2.4	0.4	-0.1	0.5	-1.6	-0.6	-0.5	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.7	0.8	0.4	0.4	-0.3	0.3	0.8
Hand grip strength (right)	0.2	0.4	1.3	1.1	0.2	0.4	-1.1	-0.5	-0.3	0.2
Fed-up feelings	0.2	0.4	1.1	0.1	0.2	0.1	1.0	1.1	0.6	0.6
Qualifications: CSEs or equivalent	0.2	0.3	1.1	1.1	0.2	-0.5	-0.4	-0.1	0.2	0.4
Nervous feelings	0.2	0.3	1.0	-0.6	-0.6	0.3	1.0	-0.2	-0.4	-0.6
Neuroticism score	0.2	0.3	1.7	-0.2	-0.1	-0.6	1.3	0.3	-0.4	0.0
Number of live births	0.2	0.3	0.9	-0.9	0.5	0.6	0.4	-0.5	0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.0	0.7	0.8	0.2	-1.4	-1.0	0.3	0.7
Happiness	0.2	0.3	1.6	-0.1	0.2	0.0	1.3	0.1	-0.4	-0.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	0.6	0.6	1.3	-0.1	0.7	1.0	0.6
Qualifications: College or University degree	0.2	0.8	2.9	-1.7	0.7	0.4	1.1	-0.4	-0.5	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.6	0.2	0.1	-0.1	0.5	-0.7	0.1
Neck or shoulder pain in last month	0.2	0.3	1.2	0.3	-0.2	0.5	-0.7	-0.3	1.1	0.4
Age at last live birth	0.2	0.3	1.0	-0.8	0.6	-0.1	-0.3	-1.0	-0.2	0.3
Supplements: Vitamin C	0.2	0.2	0.5	0.0	0.3	0.7	-0.4	-0.5	0.5	0.2
Mood swings	0.2	0.3	0.9	-0.2	0.4	0.2	0.9	0.5	0.4	0.6
Qualifications: nursing, teaching	0.2	0.4	2.2	-1.5	0.4	0.3	0.3	0.2	0.0	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	2.2	-1.5	-0.1	-0.7	-0.0	-0.1	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.5	-1.2	0.5	-0.2	0.0	-0.8	-0.9	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	-0.8	0.4	-0.6	0.4	-0.3	-0.5	0.1
Irritability	0.2	0.3	1.7	-1.3	-0.2	0.1	-0.1	-0.1	0.4	-0.0
Commuting to job workplace: Cycle	0.2	0.2	1.1	1.0	0.3	-0.5	-0.5	-0.0	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	0.2	0.5	0.6	-0.1	-1.0	-0.2	0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.7	0.1	0.4	0.2	-0.8	0.9	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.4	-0.2	-0.2	0.2	-0.7	-0.3	0.1	-0.2
Breast Cancer	0.1	0.2	0.6	0.1	0.4	0.1	0.8	-0.6	-0.3	0.2
Smoking Status	0.1	0.3	0.8	-0.6	-0.6	-0.1	-0.9	-0.4	0.5	-0.5
Respiratory disease	0.1	0.3	0.6	-0.8	-0.8	-0.2	-0.6	-0.4	-0.3	-0.7
Hair Pigment	0.1	4.1	14.7	-3.8	1.8	-0.0	2.6	-0.4	0.6	1.9
Tanning	0.1	1.6	7.7	2.8	-0.5	1.0	-1.1	0.8	0.4	-0.4
Vitamin and mineral supplements	0.1	0.2	0.8	0.5	0.0	-0.1	-0.1	-0.2	-0.9	-0.3
Severe depression (siblings)	0.1	0.1	0.3	0.1	0.3	0.1	0.1	0.5	-0.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.7	-0.0	0.1	0.0	0.6	0.9	0.1	-0.1
Multivitamins +/- minerals	0.1	0.1	0.4	-0.3	-0.1	-0.4	0.0	0.6	0.6	0.2
Past tobacco smoking	0.1	0.3	0.9	0.8	-0.0	-1.0	0.1	-0.3	-0.3	0.0
Forced vital capacity (FVC)	0.1	0.5	1.4	0.6	0.6	0.7	-1.2	-0.1	0.5	0.5
Noisy workplace	0.1	0.2	0.7	0.3	0.5	0.1	-0.2	0.2	0.8	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.9	0.9	0.1	-0.2	-0.9	-0.4	-0.1	-0.0
Birth weight	0.1	0.1	0.4	0.3	-0.7	-0.2	-0.3	0.2	-0.5	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.7	0.8	0.1	0.4	-0.7	0.2	0.2	-0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.6	-0.8	-0.1	0.3	0.1	-0.1	0.3	-0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.5	-0.3	0.3	0.7	-0.0	-0.7	0.3	0.2
Chest pain or discomfort	0.1	0.2	1.3	-0.0	0.2	-1.2	0.0	0.2	-0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	0.7	0.0	-0.7	-0.4	-0.2	0.0	0.0
Ever smoked	0.1	0.1	0.5	-0.3	-0.2	0.7	-0.3	0.4	0.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.4	-0.6	-0.5	-0.2	-0.4	-0.1	-0.1

Hub : Genes

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Models

Trait associations