Best TWAS P=2.22e-12 · Best GWAS P=6.45e-19 conditioned to 4.69e-07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | MED25 | 0.05 | 0.01 | blup | 361 | 0.02 | 2.2e-03 | -6.4 | -5.8 | 8.8e-09 | 0.03 | 0.02 | 0.90 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PNKP | 0.15 | 0.16 | enet | 23 | 0.16 | 7.0e-19 | -5.9 | -6.0 | 2.2e-09 | 0.03 | 0.40 | 0.60 | FALSE |
3 | GTEx | Adipose Visceral Omentum | PNMAL1 | 0.18 | 0.15 | lasso | 2 | 0.14 | 9.7e-08 | 5.2 | 5.2 | 2.4e-07 | -0.02 | 0.00 | 1.00 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | SAE1 | 0.21 | 0.09 | lasso | 3 | 0.07 | 2.0e-03 | -4.3 | -5.6 | 1.9e-08 | 0.77 | 0.06 | 0.67 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | TBC1D17 | 0.11 | 0.03 | enet | 23 | 0.04 | 6.5e-04 | -5.5 | 7.0 | 2.2e-12 | -0.02 | 0.16 | 0.82 | TRUE |
6 | GTEx | Colon Sigmoid | MED25 | 0.28 | 0.22 | enet | 10 | 0.17 | 1.2e-06 | -6.6 | -5.6 | 2.5e-08 | 0.07 | 0.01 | 0.99 | FALSE |
7 | GTEx | Colon Sigmoid | PRR12 | 0.20 | 0.01 | lasso | 8 | 0.00 | 4.9e-01 | 3.8 | 6.3 | 3.0e-10 | 0.02 | 0.04 | 0.28 | FALSE |
8 | GTEx | Colon Transverse | PNMAL1 | 0.35 | 0.28 | lasso | 4 | 0.27 | 2.0e-13 | 5.2 | 5.2 | 2.6e-07 | -0.02 | 0.00 | 1.00 | FALSE |
9 | GTEx | Esophagus Mucosa | AP2A1 | 0.18 | 0.09 | enet | 8 | 0.13 | 7.7e-09 | -5.8 | -7.0 | 2.5e-12 | -0.01 | 0.02 | 0.98 | FALSE |
10 | GTEx | Muscle Skeletal | FUZ | 0.09 | 0.06 | enet | 9 | 0.03 | 3.2e-04 | -6.6 | -5.5 | 4.8e-08 | 0.01 | 0.00 | 1.00 | FALSE |
11 | GTEx | Muscle Skeletal | AKT1S1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.9e-08 | -5.8 | 5.8 | 6.4e-09 | -0.05 | 0.46 | 0.54 | FALSE |
12 | GTEx | Nerve Tibial | AP2A1 | 0.16 | 0.05 | lasso | 4 | 0.07 | 1.3e-05 | -6.1 | -7.0 | 3.2e-12 | 0.02 | 0.01 | 0.99 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | CCDC9 | 0.13 | 0.00 | lasso | 5 | 0.00 | 2.2e-01 | 2.4 | -5.2 | 1.5e-07 | 0.23 | 0.11 | 0.21 | TRUE |
14 | GTEx | Skin Sun Exposed Lower leg | NTN5 | 0.11 | 0.09 | enet | 18 | 0.05 | 6.2e-05 | -3.9 | -5.3 | 1.0e-07 | 0.02 | 0.92 | 0.06 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | AP2A1 | 0.15 | 0.08 | enet | 10 | 0.07 | 1.9e-06 | -6.1 | -6.2 | 5.2e-10 | -0.01 | 0.01 | 0.98 | FALSE |
16 | GTEx | Small Intestine Terminal Ileum | PNMAL1 | 0.40 | 0.00 | enet | 11 | 0.15 | 2.7e-04 | 5.2 | 5.4 | 5.8e-08 | -0.01 | 0.02 | 0.64 | TRUE |
17 | GTEx | Spleen | PNKP | 0.51 | 0.24 | enet | 21 | 0.25 | 3.4e-07 | -5.6 | -5.1 | 3.0e-07 | -0.07 | 0.13 | 0.46 | FALSE |
18 | GTEx | Stomach | VRK3 | 0.10 | -0.01 | enet | 10 | -0.01 | 7.3e-01 | 3.8 | 6.5 | 8.7e-11 | 0.00 | 0.05 | 0.40 | FALSE |
19 | GTEx | Testis | NTN5 | 0.16 | 0.02 | enet | 23 | 0.06 | 9.6e-04 | -3.7 | -6.2 | 4.0e-10 | -0.02 | 0.02 | 0.79 | TRUE |
20 | GTEx | Testis | AC006942.4 | 0.24 | 0.03 | enet | 9 | 0.10 | 3.9e-05 | -2.8 | 5.4 | 6.5e-08 | 0.00 | 0.02 | 0.96 | FALSE |
21 | GTEx | Whole Blood | PNKP | 0.14 | 0.10 | enet | 12 | 0.12 | 1.5e-11 | -5.6 | -5.7 | 1.3e-08 | -0.04 | 0.48 | 0.52 | FALSE |
22 | METSIM | Adipose | PNMAL1 | 0.24 | 0.27 | bslmm | 380 | 0.28 | 2.9e-41 | 5.2 | 5.3 | 1.3e-07 | -0.01 | 0.00 | 1.00 | FALSE |
23 | METSIM | Adipose | SAE1 | 0.12 | 0.04 | lasso | 5 | 0.07 | 1.7e-10 | -4.0 | -6.2 | 4.2e-10 | 0.61 | 0.60 | 0.40 | TRUE |
24 | YFS | Blood | PNKP | 0.22 | 0.28 | enet | 47 | 0.30 | 3.9e-101 | -5.6 | -5.4 | 6.6e-08 | -0.03 | 0.45 | 0.55 | FALSE |
25 | YFS | Blood | SAE1 | 0.07 | 0.02 | enet | 18 | 0.05 | 3.6e-16 | -7.9 | -5.1 | 3.0e-07 | 0.56 | 0.81 | 0.19 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP2A1 | 0.04 | 0.03 | lasso | 4 | 0.04 | 1.8e-08 | -6.1 | 6.0 | 1.9e-09 | -0.02 | 0.01 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LIN7B | 0.02 | 0.00 | enet | 7 | 0.02 | 5.1e-05 | 5.2 | -5.5 | 3.5e-08 | -0.04 | 0.01 | 0.93 | TRUE |
28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED25 | 0.01 | 0.00 | blup | 47 | 0.02 | 2.9e-04 | 3.7 | -5.4 | 6.7e-08 | 0.05 | 0.06 | 0.69 | FALSE |
29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NTN5 | 0.02 | 0.01 | enet | 11 | 0.01 | 7.6e-04 | -3.9 | -5.5 | 2.8e-08 | 0.00 | 0.04 | 0.74 | FALSE |
30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSKS | 0.02 | 0.02 | blup | 41 | 0.03 | 2.1e-06 | -1.9 | -5.2 | 1.9e-07 | -0.02 | 0.65 | 0.25 | FALSE |
31 | The Cancer Genome Atlas | Colon Adenocarcinoma | SNRNP70 | 0.05 | 0.02 | lasso | 3 | 0.02 | 2.9e-02 | 4.1 | -5.3 | 9.3e-08 | -0.02 | 0.01 | 0.53 | FALSE |
32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FUT2 | 0.10 | 0.01 | blup | 51 | 0.05 | 9.8e-04 | -3.6 | 5.1 | 2.9e-07 | -0.02 | 0.03 | 0.82 | FALSE |
33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TBC1D17 | 0.06 | 0.03 | blup | 50 | 0.02 | 9.5e-04 | -5.6 | 5.3 | 1.4e-07 | -0.02 | 0.08 | 0.88 | FALSE |
34 | The Cancer Genome Atlas | Lung Adenocarcinoma | PNKP | 0.03 | 0.00 | blup | 46 | 0.02 | 4.0e-03 | -5.6 | -5.4 | 6.7e-08 | -0.05 | 0.02 | 0.09 | FALSE |
35 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | GRLF1 | 0.04 | 0.04 | blup | 51 | 0.03 | 7.0e-05 | 4.7 | 5.9 | 3.6e-09 | -0.04 | 0.43 | 0.09 | TRUE |
36 | The Cancer Genome Atlas | Thyroid Carcinoma | IL4I1 | 0.07 | 0.01 | blup | 63 | 0.03 | 7.6e-04 | -5.8 | 5.3 | 1.1e-07 | -0.02 | 0.03 | 0.71 | FALSE |