[Hub]/) : Traits : Heel T-Score : ← →

chr22:27,616,264-32,198,862

Best TWAS P=7.8e-118 · Best GWAS P=8.16e-118 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC157	0.04	0.05	lasso	3	0.04	6.3e-06	-6.346	-5.8	6.0e-09	-0.04	0.90	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GAS2L1	0.04	0.02	lasso	3	0.02	2.1e-03	-6.782	-5.6	2.0e-08	-0.09	0.68	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	KREMEN1	0.12	0.06	bslmm	410	0.08	2.8e-10	16.575	13.4	4.1e-41	0.63	0.17	0.83	FALSE
4	CommonMind	Brain Pre-frontal Cortex	RHBDD3	0.05	0.04	lasso	5	0.02	5.1e-04	-7.414	7.3	2.7e-13	0.11	0.62	0.01	FALSE
5	GTEx	Adipose Subcutaneous	KREMEN1	0.19	0.13	enet	22	0.13	9.2e-11	23.006	20.1	5.3e-90	0.87	0.00	1.00	FALSE
6	GTEx	Adipose Subcutaneous	CTA-85E5.10	0.10	0.04	lasso	9	0.03	1.9e-03	6.651	-7.0	2.7e-12	-0.12	0.37	0.51	TRUE
7	GTEx	Adipose Visceral Omentum	MTMR3	0.22	0.11	enet	17	0.10	1.1e-05	-4.562	-5.8	8.9e-09	-0.01	1.00	0.00	FALSE
8	GTEx	Adipose Visceral Omentum	CHEK2	0.14	0.03	enet	13	0.03	9.1e-03	-2.080	-8.1	7.3e-16	-0.33	0.10	0.15	FALSE
9	GTEx	Adipose Visceral Omentum	RP1-130H16.16	0.23	0.22	lasso	7	0.19	3.1e-10	-6.319	6.2	6.7e-10	0.06	0.98	0.02	FALSE
10	GTEx	Adrenal Gland	KREMEN1	0.38	0.26	lasso	3	0.22	1.7e-08	23.006	22.4	4.2e-111	0.98	0.00	1.00	FALSE
11	GTEx	Adrenal Gland	RP1-130H16.16	0.21	0.03	enet	11	0.10	2.1e-04	-6.346	6.7	1.6e-11	0.03	0.18	0.06	TRUE
12	GTEx	Artery Aorta	ZNRF3	0.17	0.17	lasso	2	0.17	8.1e-10	-9.341	9.1	1.2e-19	-0.04	1.00	0.00	FALSE
13	GTEx	Artery Aorta	GAS2L1	0.18	0.11	lasso	5	0.09	1.5e-05	-6.782	-6.8	1.2e-11	-0.09	0.93	0.00	FALSE
14	GTEx	Artery Aorta	RP1-130H16.16	0.23	0.24	lasso	7	0.23	4.6e-13	-5.612	5.5	2.8e-08	0.06	0.99	0.01	FALSE
15	GTEx	Artery Tibial	ZNRF3	0.08	0.02	lasso	5	0.00	2.9e-01	-7.140	7.5	6.6e-14	-0.01	0.43	0.02	FALSE
16	GTEx	Artery Tibial	TTC28-AS1	0.12	0.05	lasso	6	0.03	9.4e-04	-7.364	-5.1	3.0e-07	0.04	0.68	0.02	FALSE
17	GTEx	Artery Tibial	RP1-130H16.16	0.12	0.11	enet	19	0.12	2.0e-09	-6.346	7.6	3.5e-14	0.05	0.98	0.02	TRUE
18	GTEx	Brain Frontal Cortex BA9	RP1-130H16.16	0.20	0.12	lasso	10	0.15	8.4e-05	-5.614	5.6	1.8e-08	0.08	0.13	0.62	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	GAS2L1	0.36	-0.01	enet	26	0.10	1.3e-03	3.636	-6.1	1.2e-09	-0.12	0.07	0.06	FALSE
20	GTEx	Breast Mammary Tissue	KREMEN1	0.14	0.06	enet	10	0.10	6.9e-06	16.628	18.2	2.1e-74	0.85	0.01	0.98	FALSE
21	GTEx	Breast Mammary Tissue	RP1-130H16.16	0.14	0.05	lasso	6	0.07	1.5e-04	-6.332	5.8	5.5e-09	0.05	0.89	0.04	FALSE
22	GTEx	Breast Mammary Tissue (Male)	KREMEN1	0.08	-0.01	enet	2	-0.01	4.9e-01	13.222	13.1	4.3e-39	0.62	0.03	0.29	FALSE
23	GTEx	Breast Mammary Tissue (Female)	CTA-85E5.10	0.13	-0.01	lasso	4	-0.01	5.7e-01	5.279	-5.3	1.3e-07	-0.03	0.06	0.06	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	UQCR10	0.12	0.03	lasso	4	0.06	6.6e-03	5.777	-5.6	2.3e-08	-0.06	0.12	0.07	TRUE
25	GTEx	Cells Transformed fibroblasts	NEFH	0.10	0.00	enet	32	0.00	1.4e-01	1.366	-5.5	4.8e-08	-0.24	0.10	0.09	FALSE
26	GTEx	Cells Transformed fibroblasts	ASCC2	0.05	0.05	lasso	4	0.04	6.8e-04	-6.256	-5.3	9.0e-08	-0.01	0.51	0.02	FALSE
27	GTEx	Cells Transformed fibroblasts	CCDC117	0.10	0.01	lasso	6	0.02	2.4e-02	-1.669	-5.2	1.7e-07	-0.03	0.19	0.17	FALSE
28	GTEx	Cells Transformed fibroblasts	SMTN	0.05	0.00	lasso	4	0.00	1.5e-01	4.689	5.8	7.0e-09	0.03	0.03	0.51	TRUE
29	GTEx	Cells Transformed fibroblasts	RP1-130H16.16	0.25	0.22	enet	31	0.21	1.0e-15	-6.319	6.0	2.1e-09	0.04	0.98	0.02	FALSE
30	GTEx	Colon Sigmoid	RP1-130H16.16	0.27	0.25	lasso	17	0.24	5.1e-09	-6.346	6.1	1.3e-09	0.05	0.97	0.02	FALSE
31	GTEx	Colon Transverse	MTMR3	0.33	0.29	enet	24	0.33	3.5e-16	-4.562	-5.2	2.5e-07	0.00	1.00	0.00	FALSE
32	GTEx	Colon Transverse	RP1-130H16.16	0.28	0.20	lasso	6	0.20	1.1e-09	-6.319	5.7	1.2e-08	0.04	0.98	0.02	FALSE
33	GTEx	Esophagus Mucosa	HSCB	0.10	0.04	enet	8	0.05	2.2e-04	-10.666	8.8	1.7e-18	0.00	0.82	0.01	FALSE
34	GTEx	Esophagus Mucosa	AP1B1	0.06	0.05	lasso	3	0.05	1.8e-04	-7.447	-7.0	2.8e-12	-0.04	0.62	0.03	FALSE
35	GTEx	Esophagus Mucosa	RP1-130H16.16	0.11	0.13	enet	26	0.13	9.3e-09	-6.319	5.3	1.4e-07	0.05	0.98	0.02	FALSE
36	GTEx	Esophagus Mucosa	MTFP1	0.10	0.00	lasso	6	0.01	1.3e-01	-5.630	-5.6	1.9e-08	-0.06	0.19	0.09	TRUE
37	GTEx	Esophagus Muscularis	RP1-130H16.16	0.20	0.14	lasso	4	0.14	1.5e-08	-5.630	5.6	1.8e-08	0.07	0.98	0.01	FALSE
38	GTEx	Heart Atrial Appendage	RNF215	0.46	0.46	lasso	6	0.43	4.2e-21	-5.632	-5.7	1.0e-08	-0.06	0.98	0.02	FALSE
39	GTEx	Heart Atrial Appendage	CCDC157	0.38	0.29	lasso	7	0.31	1.2e-14	-6.425	-6.2	6.2e-10	-0.06	0.98	0.02	FALSE
40	GTEx	Heart Left Ventricle	RNF215	0.21	0.26	enet	11	0.24	4.3e-13	-5.612	-5.8	6.5e-09	-0.06	0.99	0.01	FALSE
41	GTEx	Heart Left Ventricle	KREMEN1	0.47	0.32	lasso	6	0.34	5.0e-19	20.555	21.9	2.5e-106	0.96	0.01	0.99	FALSE
42	GTEx	Heart Left Ventricle	CCDC157	0.10	0.02	lasso	3	0.03	7.9e-03	-5.143	-5.2	1.7e-07	-0.04	0.57	0.04	FALSE
43	GTEx	Lung	RP1-130H16.16	0.08	0.08	enet	13	0.08	1.9e-06	-5.630	5.2	1.6e-07	0.06	0.90	0.02	FALSE
44	GTEx	Muscle Skeletal	RNF215	0.09	0.00	enet	8	0.01	4.1e-02	-5.632	-6.9	5.0e-12	0.03	0.44	0.05	TRUE
45	GTEx	Muscle Skeletal	RP1-130H16.16	0.07	0.04	lasso	3	0.03	4.7e-04	-5.143	6.5	8.8e-11	0.05	0.46	0.06	FALSE
46	GTEx	Nerve Tibial	RNF215	0.08	0.07	lasso	2	0.06	9.3e-05	-6.332	6.3	2.4e-10	0.05	0.82	0.04	FALSE
47	GTEx	Nerve Tibial	GATSL3	0.10	0.04	lasso	9	0.03	1.8e-03	-6.425	6.5	9.6e-11	0.05	0.86	0.04	FALSE
48	GTEx	Nerve Tibial	RP1-130H16.16	0.19	0.16	enet	24	0.17	2.4e-12	-6.319	5.6	1.7e-08	0.03	0.98	0.02	FALSE
49	GTEx	Ovary	KREMEN1	0.28	0.18	enet	5	0.19	1.7e-05	20.555	21.0	1.2e-97	0.87	0.04	0.81	FALSE
50	GTEx	Pancreas	XBP1	0.15	0.13	lasso	6	0.14	1.3e-06	-7.188	7.3	2.2e-13	0.01	0.85	0.01	FALSE
51	GTEx	Pancreas	RHBDD3	0.18	0.12	lasso	5	0.13	2.9e-06	-7.414	8.2	2.6e-16	0.07	0.89	0.01	TRUE
52	GTEx	Pancreas	KREMEN1	0.33	0.24	lasso	7	0.23	4.2e-10	23.056	22.1	1.7e-108	0.99	0.00	1.00	FALSE
53	GTEx	Pancreas	CCDC157	0.14	0.06	lasso	3	0.07	8.7e-04	-6.319	7.1	1.6e-12	0.06	0.30	0.08	FALSE
54	GTEx	Pancreas	CTA-984G1.5	0.14	0.14	lasso	2	0.11	2.0e-05	-7.435	7.4	1.0e-13	-0.03	0.60	0.02	FALSE
55	GTEx	Pancreas	RP1-130H16.16	0.16	0.13	lasso	7	0.11	2.3e-05	-6.319	6.5	1.2e-10	0.05	0.70	0.12	FALSE
56	GTEx	Prostate	MTMR3	0.62	0.29	lasso	14	0.24	9.3e-07	-4.044	-5.6	2.5e-08	-0.02	0.93	0.01	FALSE
57	GTEx	Prostate	CTA-85E5.10	0.24	0.00	lasso	4	0.02	1.2e-01	-4.017	-5.2	2.3e-07	-0.01	0.17	0.08	FALSE
58	GTEx	Prostate	RP1-130H16.16	0.24	0.01	lasso	7	0.02	8.2e-02	-4.311	6.1	1.0e-09	0.09	0.08	0.19	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	RP1-130H16.16	0.16	0.13	enet	24	0.14	3.0e-08	-5.612	6.5	8.5e-11	0.04	0.98	0.02	FALSE
60	GTEx	Skin Sun Exposed Lower leg	CCDC117	0.07	0.03	enet	11	0.03	2.8e-03	-1.738	-8.6	6.7e-18	-0.27	0.08	0.63	TRUE
61	GTEx	Skin Sun Exposed Lower leg	UQCR10	0.07	0.10	lasso	8	0.09	5.5e-08	5.279	5.3	1.1e-07	0.05	1.00	0.00	FALSE
62	GTEx	Skin Sun Exposed Lower leg	CCDC157	0.15	0.06	lasso	3	0.04	5.0e-04	-5.614	5.3	1.1e-07	0.06	0.52	0.21	FALSE
63	GTEx	Skin Sun Exposed Lower leg	RP1-130H16.16	0.13	0.10	lasso	2	0.08	1.8e-07	-5.614	5.7	1.5e-08	0.06	0.98	0.02	FALSE
64	GTEx	Spleen	RHBDD3	0.48	0.02	lasso	5	0.09	2.0e-03	-3.299	5.4	6.0e-08	0.09	0.06	0.06	FALSE
65	GTEx	Spleen	CCDC157	0.25	0.01	lasso	14	0.02	8.6e-02	-6.332	6.4	2.0e-10	0.02	0.12	0.10	FALSE
66	GTEx	Spleen	RP1-130H16.16	0.35	0.27	lasso	3	0.25	4.9e-07	-6.346	6.9	5.0e-12	0.05	0.75	0.04	FALSE
67	GTEx	Stomach	MTMR3	0.22	0.16	enet	10	0.13	7.4e-07	-4.562	-5.6	1.9e-08	-0.02	0.78	0.12	FALSE
68	GTEx	Stomach	CCDC157	0.21	0.02	lasso	5	0.03	9.2e-03	-5.614	6.8	1.4e-11	0.05	0.04	0.87	TRUE
69	GTEx	Stomach	RP1-130H16.16	0.16	0.12	lasso	7	0.07	2.9e-04	-6.332	6.6	5.0e-11	0.07	0.81	0.11	FALSE
70	GTEx	Testis	TTC28	0.29	0.04	lasso	19	0.05	2.6e-03	-6.858	-6.9	6.4e-12	-0.12	0.70	0.02	FALSE
71	GTEx	Testis	AP1B1	0.18	0.13	enet	15	0.10	5.0e-05	-6.516	6.4	1.7e-10	0.05	0.59	0.02	FALSE
72	GTEx	Testis	MTMR3	0.27	0.17	enet	13	0.26	8.9e-12	-6.513	-5.8	6.9e-09	-0.02	0.97	0.03	FALSE
73	GTEx	Testis	RP1-130H16.16	0.25	0.17	lasso	4	0.20	3.3e-09	-4.311	-5.4	6.5e-08	-0.09	0.82	0.14	FALSE
74	GTEx	Thyroid	HSCB	0.08	0.03	lasso	5	0.05	8.9e-05	0.054	6.0	2.7e-09	-0.08	0.28	0.10	TRUE
75	GTEx	Thyroid	KREMEN1	0.10	0.09	lasso	3	0.08	1.3e-06	23.076	23.1	7.8e-118	1.00	0.00	1.00	TRUE
76	GTEx	Thyroid	RP1-130H16.16	0.19	0.18	lasso	7	0.19	8.8e-15	-5.612	6.4	1.3e-10	0.07	0.99	0.01	FALSE
77	GTEx	Whole Blood	NIPSNAP1	0.05	0.00	enet	19	0.01	8.8e-02	-0.154	-5.7	1.2e-08	-0.12	0.09	0.14	FALSE
78	METSIM	Adipose	CCDC117	0.05	0.05	lasso	2	0.03	8.1e-06	-6.315	-6.3	3.1e-10	0.00	0.97	0.00	FALSE
79	METSIM	Adipose	KREMEN1	0.12	0.12	lasso	8	0.11	1.7e-16	22.158	22.0	1.3e-107	0.97	0.00	1.00	FALSE
80	NTR	Blood	KREMEN1	0.05	0.04	lasso	5	0.04	1.4e-12	13.790	-12.1	8.0e-34	-0.54	1.00	0.00	TRUE
81	NTR	Blood	XBP1	0.03	0.03	bslmm	324	0.03	8.2e-09	-4.252	-8.5	2.6e-17	0.07	1.00	0.00	TRUE
82	YFS	Blood	CCDC117	0.03	0.02	lasso	3	0.02	3.1e-08	-10.254	7.0	3.6e-12	0.05	0.87	0.00	FALSE
83	YFS	Blood	KREMEN1	0.10	0.10	enet	14	0.10	1.3e-32	16.032	-14.7	8.8e-49	-0.65	1.00	0.00	FALSE
84	YFS	Blood	XBP1	0.13	0.14	enet	37	0.20	1.1e-64	-9.524	-9.8	6.9e-23	0.13	1.00	0.00	TRUE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC157	0.03	0.01	blup	64	0.02	9.1e-06	3.262	-5.7	1.2e-08	-0.03	0.04	0.96	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSCB	0.05	0.00	blup	43	0.02	1.3e-05	-10.428	5.7	1.5e-08	-0.04	0.01	0.90	TRUE
87	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ASCC2	0.07	0.07	enet	5	0.07	2.5e-04	5.286	-5.5	3.7e-08	-0.03	0.10	0.05	FALSE
88	The Cancer Genome Atlas	Colon Adenocarcinoma	C22orf31	0.07	0.02	blup	64	0.06	2.7e-04	7.051	10.8	4.4e-27	0.64	0.04	0.51	FALSE
89	The Cancer Genome Atlas	Esophageal Carcinoma	MTMR3	0.23	0.04	lasso	8	0.08	1.4e-03	-4.471	-5.5	4.9e-08	0.00	0.12	0.11	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP1B1	0.04	0.02	enet	6	0.03	4.9e-04	-7.414	6.7	2.4e-11	0.09	0.33	0.02	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC157	0.04	0.02	lasso	3	0.03	2.1e-04	-2.982	-5.1	2.7e-07	0.00	0.02	0.89	TRUE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSCB	0.08	0.04	lasso	3	0.04	1.4e-05	-4.092	5.3	1.2e-07	-0.08	0.27	0.27	FALSE
93	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KREMEN1	0.13	0.10	lasso	5	0.11	3.3e-12	20.528	21.5	5.7e-103	0.93	0.03	0.97	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RHBDD3	0.03	0.00	blup	48	0.02	1.6e-03	-0.752	7.0	2.1e-12	0.12	0.03	0.04	FALSE
95	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHEK2	0.08	0.03	blup	46	0.04	2.5e-03	-4.249	6.4	1.6e-10	-0.15	0.04	0.39	FALSE
96	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASCC2	0.04	0.00	blup	48	0.01	1.1e-02	1.243	-5.5	3.7e-08	-0.12	0.02	0.46	TRUE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC157	0.11	0.09	lasso	13	0.10	1.5e-11	-5.143	-5.2	1.7e-07	-0.05	0.07	0.93	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	RHBDD3	0.03	0.01	blup	49	0.01	3.4e-02	4.848	7.3	2.1e-13	0.17	0.03	0.04	TRUE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	XBP1	0.04	0.03	enet	19	0.02	1.3e-03	-10.124	10.6	2.7e-26	-0.07	0.00	0.95	TRUE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC157	0.03	0.02	blup	64	0.03	1.6e-04	-2.628	-5.5	4.5e-08	-0.04	0.02	0.94	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	HSCB	0.04	0.00	blup	42	0.01	4.0e-02	4.573	6.2	5.2e-10	0.15	0.01	0.35	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HSCB	0.03	0.01	blup	43	0.01	1.3e-02	-10.428	7.4	1.2e-13	0.04	0.01	0.69	TRUE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RHBDD3	0.07	0.02	blup	47	0.03	1.4e-04	-0.752	5.5	4.4e-08	0.17	0.08	0.04	FALSE
104	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC157	0.09	0.01	blup	64	0.06	2.1e-03	-5.614	-6.4	1.2e-10	-0.03	0.02	0.52	FALSE
105	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HSCB	0.12	0.02	blup	43	0.09	1.9e-04	-4.249	7.7	1.2e-14	-0.03	0.01	0.92	TRUE
106	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	XBP1	0.06	0.03	blup	35	0.06	1.6e-03	-9.131	8.2	2.2e-16	0.02	0.04	0.18	FALSE
107	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RHBDD3	0.10	0.00	blup	49	0.02	3.6e-02	-0.710	5.9	3.6e-09	-0.03	0.01	0.67	TRUE
108	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAS2L1	0.04	0.02	blup	38	0.04	2.8e-05	-7.414	-5.6	2.3e-08	-0.08	0.33	0.04	FALSE
109	The Cancer Genome Atlas	Prostate Adenocarcinoma	RHBDD3	0.06	0.02	blup	48	0.03	3.5e-04	4.848	7.5	5.9e-14	0.26	0.12	0.02	TRUE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC14L2	0.12	0.08	blup	74	0.12	1.1e-12	-5.143	5.6	2.7e-08	0.09	0.01	0.98	FALSE
111	The Cancer Genome Atlas	Prostate Adenocarcinoma	XBP1	0.03	0.02	blup	35	0.02	1.1e-03	-9.339	6.6	4.7e-11	-0.01	0.14	0.06	FALSE
112	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZNRF3	0.44	-0.01	blup	126	0.05	2.0e-02	-3.038	14.0	2.6e-44	0.62	0.01	0.24	FALSE
113	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TTC28	0.11	0.08	enet	18	0.11	1.5e-04	-6.896	6.3	3.5e-10	-0.09	0.08	0.61	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC157	0.04	0.03	blup	64	0.04	5.8e-05	-5.612	-6.0	2.7e-09	-0.05	0.02	0.98	TRUE