[Hub]/) : Traits : Impedance of leg (left) : ← →

chr1:153,973,171-156,572,984

Best TWAS P=1.57e-40 · Best GWAS P=1.25e-40 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	GTEx	Skin Sun Exposed Lower leg	ADAM15	0.14	0.09	lasso	4	0.08	6.1e-07	-13.3	13.3	1.6e-40	-0.96	0.00	1.00	TRUE
64	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM46	0.03	0.00	blup	33	0.02	3.6e-03	8.4	9.1	9.6e-20	-0.11	0.01	0.62	TRUE
28	GTEx	Esophagus Mucosa	MUC1	0.17	0.20	lasso	4	0.18	5.6e-12	8.4	8.4	4.8e-17	-0.12	1.00	0.00	TRUE
56	METSIM	Adipose	DCST2	0.04	0.04	enet	12	0.04	4.3e-07	4.6	-6.7	2.4e-11	0.47	0.86	0.11	TRUE
41	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	5.6	-6.5	7.5e-11	0.03	0.16	0.07	TRUE
48	GTEx	Thyroid	GON4L	0.08	0.02	enet	28	0.00	4.0e-01	3.2	-6.2	7.9e-10	0.03	0.05	0.67	TRUE
4	GTEx	Adipose Subcutaneous	RP11-307C12.11	0.09	0.02	lasso	3	0.02	1.2e-02	4.3	-5.7	9.9e-09	0.25	0.33	0.03	TRUE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZBTB7B	0.05	0.06	lasso	2	0.05	1.8e-06	-13.3	13.3	1.9e-40	-1.00	0.00	1.00	FALSE
9	GTEx	Brain Cerebellar Hemisphere	DCST2	0.45	0.10	lasso	6	0.16	6.6e-05	6.1	-11.1	1.7e-28	0.75	0.01	0.96	FALSE
35	GTEx	Pancreas	RP11-263K19.4	0.22	0.06	enet	23	0.05	3.1e-03	-5.2	10.4	1.9e-25	-0.43	0.06	0.49	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	SLC50A1	0.06	0.02	bslmm	331	0.03	4.3e-05	8.4	8.7	5.1e-18	-0.27	0.65	0.04	FALSE
20	GTEx	Breast Mammary Tissue (Female)	FAM189B	0.05	-0.01	lasso	2	0.00	4.8e-01	8.6	-8.6	1.1e-17	0.09	0.04	0.07	FALSE
33	GTEx	Pancreas	THBS3	0.36	0.14	lasso	6	0.12	1.0e-05	-5.2	8.2	1.9e-16	-0.34	0.18	0.54	FALSE
53	GTEx	Vagina	GBAP1	0.27	0.08	lasso	7	0.17	1.3e-04	7.8	-8.1	4.2e-16	0.09	0.25	0.05	FALSE
50	GTEx	Thyroid	DCST2	0.16	0.12	lasso	2	0.11	6.4e-09	6.1	-8.1	7.8e-16	0.53	0.38	0.62	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	DCST2	0.28	0.04	lasso	5	0.13	2.0e-04	-13.3	-8.1	8.5e-16	0.69	0.02	0.90	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	GBAP1	0.15	0.06	lasso	4	0.06	3.6e-04	8.6	-7.7	1.2e-14	0.11	0.54	0.04	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	LENEP	0.01	0.00	blup	37	0.01	1.6e-03	5.6	-7.6	2.8e-14	0.48	0.02	0.30	FALSE
74	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MUC1	0.04	0.01	enet	4	0.02	1.3e-03	8.4	7.6	4.1e-14	-0.15	0.02	0.54	FALSE
51	GTEx	Thyroid	MUC1	0.11	0.02	enet	15	0.09	1.5e-07	-5.2	-7.5	5.6e-14	0.13	0.98	0.00	FALSE
59	NTR	Blood	ZBTB7B	0.02	0.02	lasso	1	0.01	5.4e-05	-7.5	-7.5	6.7e-14	0.67	0.87	0.03	FALSE
42	GTEx	Spleen	SHC1	0.22	0.14	lasso	2	0.08	4.0e-03	7.8	7.5	6.9e-14	-0.15	0.14	0.05	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	5.6	-7.3	2.9e-13	0.07	0.02	0.91	FALSE
22	GTEx	Cells Transformed fibroblasts	SLC50A1	0.08	0.07	lasso	6	0.07	3.9e-06	5.6	7.3	3.2e-13	-0.07	0.95	0.00	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM46	0.03	0.01	blup	32	0.01	4.9e-03	8.6	7.2	5.7e-13	-0.11	0.01	0.39	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	8.7	7.1	1.0e-12	-0.07	0.01	0.99	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAG1AP1	0.07	0.00	blup	76	0.00	2.9e-01	3.1	7.0	2.0e-12	-0.17	0.02	0.36	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	-2.2	-7.0	2.5e-12	0.05	0.88	0.00	FALSE
13	GTEx	Brain Cerebellum	THBS3	0.17	0.15	enet	6	0.16	2.0e-05	-5.2	7.0	3.2e-12	-0.09	0.49	0.03	FALSE
23	GTEx	Colon Sigmoid	GBAP1	0.16	0.13	enet	8	0.14	8.4e-06	-5.2	-7.0	3.5e-12	0.09	0.65	0.04	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	YY1AP1	0.03	0.01	enet	3	0.01	1.6e-03	5.9	-6.7	2.4e-11	-0.02	0.00	0.97	FALSE
46	GTEx	Testis	MUC1	0.20	0.02	lasso	7	0.07	7.5e-04	8.6	6.6	3.1e-11	-0.11	0.27	0.05	FALSE
44	GTEx	Spleen	THBS3	0.23	0.10	enet	17	0.08	4.6e-03	7.8	6.6	3.2e-11	-0.07	0.23	0.04	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	-5.2	-6.6	3.4e-11	0.06	0.01	0.57	FALSE
18	GTEx	Brain Putamen basal ganglia	DCST2	0.56	0.05	enet	11	0.10	2.8e-03	6.1	-6.6	3.7e-11	0.47	0.18	0.58	FALSE
61	YFS	Blood	MTX1	0.06	0.02	blup	331	0.03	1.9e-10	-5.2	6.6	3.7e-11	-0.27	1.00	0.00	FALSE
43	GTEx	Spleen	GBAP1	0.33	0.23	enet	20	0.28	7.9e-08	-4.9	-6.6	3.9e-11	0.09	0.84	0.01	FALSE
63	YFS	Blood	THBS3	0.29	0.22	enet	38	0.31	6.4e-105	-5.2	6.4	1.5e-10	-0.06	1.00	0.00	FALSE
5	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	-5.2	-6.3	2.7e-10	0.05	1.00	0.00	FALSE
12	GTEx	Brain Cerebellum	DCST2	0.48	0.27	lasso	9	0.31	6.0e-10	4.7	-6.3	2.9e-10	0.42	0.86	0.11	FALSE
82	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAP1	0.05	0.04	blup	26	0.04	1.6e-03	-5.2	-6.2	4.1e-10	0.10	0.02	0.72	FALSE
11	GTEx	Brain Cerebellum	MSTO1	0.15	0.06	enet	13	0.07	4.0e-03	5.6	6.2	5.3e-10	-0.01	0.18	0.36	FALSE
7	GTEx	Artery Tibial	GBAP1	0.21	0.26	lasso	7	0.26	1.3e-20	-5.2	-6.2	6.0e-10	0.07	1.00	0.00	FALSE
37	GTEx	Prostate	GBAP1	0.47	0.30	lasso	7	0.32	1.1e-08	-5.2	-6.1	1.3e-09	0.08	0.91	0.00	FALSE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	GBAP1	0.10	0.06	enet	9	0.04	5.1e-03	-5.2	-6.1	1.4e-09	0.02	0.02	0.29	FALSE
76	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THBS3	0.02	0.03	lasso	4	0.03	2.1e-04	-5.2	6.0	1.8e-09	-0.08	0.06	0.83	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	-4.9	-6.0	2.0e-09	0.08	0.90	0.01	FALSE
47	GTEx	Testis	RP11-29H23.5	0.49	0.34	lasso	5	0.39	2.4e-18	5.9	-6.0	2.2e-09	0.03	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	DAP3	0.13	0.12	lasso	2	0.13	2.8e-04	5.9	5.9	3.4e-09	-0.02	0.06	0.63	FALSE
52	GTEx	Thyroid	MSTO2P	0.05	0.05	lasso	5	0.04	6.2e-04	5.3	-5.9	4.2e-09	-0.04	0.68	0.05	FALSE
45	GTEx	Testis	YY1AP1	0.54	0.34	lasso	7	0.38	4.7e-18	5.9	-5.8	4.9e-09	0.03	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	THBS3	0.02	0.02	blup	26	0.02	4.0e-05	-5.2	5.8	5.8e-09	-0.05	0.20	0.52	FALSE
2	CommonMind	Brain Pre-frontal Cortex	THBS3	0.12	0.01	enet	23	0.07	5.6e-09	-5.2	5.8	6.6e-09	0.00	0.56	0.02	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCST2	0.04	0.01	blup	50	0.03	2.0e-04	5.2	5.8	7.1e-09	-0.37	0.22	0.10	FALSE
6	GTEx	Artery Tibial	RIT1	0.09	0.04	lasso	4	0.04	1.9e-04	4.1	-5.7	9.4e-09	-0.02	0.09	0.88	FALSE
36	GTEx	Pituitary	KCNN3	0.41	0.31	lasso	6	0.28	7.4e-08	5.2	5.7	1.1e-08	-0.29	0.88	0.04	FALSE
57	METSIM	Adipose	THBS3	0.09	0.10	lasso	7	0.12	4.7e-17	-5.2	5.7	1.1e-08	-0.02	1.00	0.00	FALSE
26	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	-5.2	-5.6	2.6e-08	0.04	1.00	0.00	FALSE
34	GTEx	Pancreas	MSTO2P	0.20	0.12	lasso	3	0.07	4.6e-04	5.9	-5.5	3.5e-08	0.01	0.58	0.03	FALSE
32	GTEx	Nerve Tibial	PBXIP1	0.08	0.02	enet	9	0.04	5.3e-04	2.5	-5.5	3.7e-08	0.31	0.69	0.12	FALSE
24	GTEx	Colon Transverse	RP11-307C12.11	0.15	0.13	lasso	3	0.10	1.5e-05	5.2	-5.4	5.5e-08	0.37	0.87	0.10	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	MSTO2P	0.04	0.00	enet	9	0.02	4.2e-03	4.3	-5.4	5.7e-08	0.06	0.00	0.29	FALSE
49	GTEx	Thyroid	GBAP1	0.23	0.28	lasso	10	0.27	4.6e-21	-5.2	-5.4	8.0e-08	0.07	1.00	0.00	FALSE
14	GTEx	Brain Cerebellum	EFNA1	0.20	0.09	enet	13	0.06	9.2e-03	5.6	-5.4	8.2e-08	0.05	0.38	0.03	FALSE
3	GTEx	Adipose Subcutaneous	PBXIP1	0.06	0.04	lasso	5	0.02	5.8e-03	4.6	-5.4	8.4e-08	0.25	0.61	0.02	FALSE
15	GTEx	Brain Cortex	GBAP1	0.25	0.14	enet	25	0.23	4.7e-07	-4.9	5.4	8.6e-08	-0.07	0.74	0.01	FALSE
21	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	-5.2	-5.3	1.1e-07	0.04	1.00	0.00	FALSE
58	NTR	Blood	THBS3	0.03	0.02	blup	341	0.02	2.8e-08	-5.2	5.3	1.1e-07	0.05	1.00	0.00	FALSE
62	YFS	Blood	PBXIP1	0.04	0.03	enet	13	0.03	6.2e-10	4.9	-5.3	1.1e-07	0.29	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	MSTO2P	0.02	0.02	lasso	2	0.01	1.0e-03	5.3	-5.3	1.1e-07	-0.07	0.04	0.68	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	THBS3	0.10	0.12	enet	11	0.10	4.4e-11	-5.2	5.3	1.1e-07	-0.09	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	MSTO2P	0.05	0.03	lasso	3	0.03	4.9e-04	5.3	-5.3	1.2e-07	-0.07	0.05	0.71	FALSE
16	GTEx	Brain Frontal Cortex BA9	MTX1P1	0.20	0.05	enet	21	0.01	1.5e-01	8.3	5.3	1.4e-07	0.02	0.08	0.05	FALSE
72	The Cancer Genome Atlas	Esophageal Carcinoma	FAM189B	0.36	0.05	lasso	3	0.02	6.1e-02	-5.2	-5.3	1.4e-07	0.07	0.00	0.26	FALSE
29	GTEx	Esophagus Mucosa	RP11-263K19.4	0.14	0.14	lasso	4	0.12	1.5e-08	-5.2	5.2	1.6e-07	-0.07	1.00	0.00	FALSE
27	GTEx	Esophagus Mucosa	THBS3	0.15	0.15	lasso	2	0.13	6.8e-09	-5.2	5.2	1.7e-07	-0.07	1.00	0.00	FALSE
19	GTEx	Breast Mammary Tissue	GBAP1	0.15	0.17	lasso	2	0.15	5.2e-08	-5.2	-5.2	1.8e-07	0.07	0.98	0.00	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	GBAP1	0.02	0.03	enet	2	0.02	2.3e-03	-5.2	-5.2	1.8e-07	0.07	0.03	0.43	FALSE
10	GTEx	Brain Cerebellar Hemisphere	THBS3	0.19	0.26	lasso	2	0.24	8.6e-07	-5.2	5.2	1.9e-07	-0.08	0.49	0.03	FALSE
31	GTEx	Nerve Tibial	GBAP1	0.12	0.14	lasso	1	0.14	8.9e-10	-5.2	-5.2	1.9e-07	0.07	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM46	0.08	0.08	lasso	2	0.07	2.1e-05	-5.2	5.2	1.9e-07	-0.07	0.13	0.58	FALSE
54	GTEx	Whole Blood	THBS3	0.17	0.20	enet	5	0.21	1.0e-18	-5.2	5.2	2.1e-07	-0.07	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RAG1AP1	0.17	0.00	blup	77	0.04	1.1e-03	2.5	5.2	2.1e-07	-0.07	0.02	0.28	FALSE
40	GTEx	Skin Sun Exposed Lower leg	RP11-307C12.11	0.22	0.12	lasso	6	0.10	4.9e-09	5.2	-5.2	2.2e-07	0.32	1.00	0.00	FALSE
55	GTEx	Whole Blood	RP11-263K19.4	0.15	0.17	lasso	4	0.17	9.5e-16	-5.2	5.2	2.6e-07	-0.07	1.00	0.00	FALSE
30	GTEx	Esophagus Muscularis	GBAP1	0.09	0.13	enet	4	0.12	8.9e-08	-4.9	-5.1	2.7e-07	0.07	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	HCN3	0.08	0.00	lasso	3	0.00	5.7e-01	5.2	-5.1	3.1e-07	0.04	0.00	0.39	FALSE