Hub : Genes

FCHO1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0760 0.0320 1.4e-02 0.027 0.033 0.030 0.040 0.043 2.6e-04 5.9e-05 1.3e-04 9.7e-06 4.9e-06
2 GTEx Brain Cerebellum 0.3950 0.1180 9.4e-03 0.183 NA 0.114 NA 0.159 4.4e-06 NA 3.0e-04 NA 2.0e-05
3 GTEx Nerve Tibial 0.2091 0.0561 3.8e-04 0.044 NA 0.065 NA 0.053 4.2e-04 NA 2.3e-05 NA 1.3e-04
4 GTEx Whole Blood 0.1510 0.0370 3.1e-05 0.114 NA 0.085 NA 0.091 1.2e-10 NA 3.1e-08 NA 9.6e-09
5 METSIM Adipose 0.0459 0.0185 6.6e-03 0.030 0.012 0.029 0.024 0.038 2.0e-05 4.7e-03 2.7e-05 1.2e-04 2.1e-06
6 ROSMAP Brain Pre-frontal Cortex 0.1133 0.0330 1.5e-04 0.040 0.035 0.064 0.048 0.027 5.8e-06 2.0e-05 1.3e-08 7.7e-07 1.9e-04
7 YFS Blood 0.0951 0.0178 1.7e-16 0.069 0.053 0.067 0.068 0.067 1.5e-21 6.7e-17 5.5e-21 2.0e-21 4.8e-21

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.8 1.3 2.9 1.4 1.0 0.6 -1.7 1.4 -0.8 -0.1
Bipolar Disorder or Schizophrenia 0.5 1.3 3.9 0.9 1.9 -0.3 -2.0 0.7 -0.5 -0.5
Depressed Affect (Nagel 2018) 1.9 4.0 10.2 0.4 -0.5 -2.0 2.6 -3.2 1.5 -2.0
Depression (Nagel 2018) 2.5 3.8 7.2 1.3 -0.1 -2.4 2.2 -2.4 1.2 -2.7
Intelligence (Savage-Jansen 2018) 3.0 9.1 19.8 -2.8 -1.5 4.5 -3.4 3.9 -0.9 2.5
Neuroticism (Nagel 2018) 1.8 4.2 8.1 1.4 -1.9 -2.0 1.6 -2.8 1.4 -2.7
Schizophrenia (2018) 0.3 0.7 2.7 -0.0 1.6 -0.8 -1.1 -0.3 0.2 -0.6
Schizophrenia vs Biploar Disorder 1.0 1.4 3.4 0.6 0.0 -1.3 1.1 -1.6 0.7 -1.8
Worry (Nagel 2018) 2.0 4.3 5.6 2.3 -1.9 -2.0 1.8 -2.4 2.0 -2.1
Alzheimer’s Disease (in mother) 1.1 1.3 2.2 1.5 -0.3 -1.2 -0.7 -0.8 -1.4 -1.5
Alzheimer’s Disease (in father) 0.7 0.8 2.6 -1.2 1.0 -0.5 -1.6 0.2 -0.1 -0.4
Alzheimer’s Disease (including proxy) 0.6 0.8 2.6 0.4 0.5 -0.9 -1.6 0.1 -1.2 -0.6
Crohns Disease (2017) 2.2 4.8 8.9 2.1 1.0 -3.0 1.8 -2.6 1.8 -2.4
Irritable Bowel Disease (IBD) 3.3 7.9 14.2 2.9 0.7 -3.8 2.1 -3.6 1.4 -3.6
Ulcerative Colitis (UC) 2.6 4.9 9.5 2.1 0.1 -3.0 1.6 -2.9 0.7 -3.1
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.9 3.6 9.7 0.1 0.6 -0.9 2.9 -1.0 2.2 -3.1
Verbal and Numeric Reasoning (VNR) 3.9 9.4 18.7 -2.4 -0.9 4.3 -4.2 4.1 -1.3 2.1
Breast Cancer 1.0 2.5 12.2 -0.8 0.5 -0.1 1.9 -0.5 3.5 -0.7
Ovarian Cancer 0.5 0.6 2.1 1.1 0.5 0.3 -0.9 -0.0 1.5 -0.1
Prostate Cancer 0.6 0.8 2.3 -0.7 1.5 -0.7 -0.0 -0.2 -1.4 0.3
Age at First Birth 0.4 0.6 2.7 0.0 -0.3 -0.5 0.2 -0.5 1.6 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 3.7 -0.3 0.5 0.5 -1.7 0.6 -1.9 0.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.8 1.4 2.9 1.1 0.1 -1.7 1.2 -1.6 -0.2 -1.2
Mean Putamen Volume 1.2 1.3 3.2 1.0 -0.1 -1.6 0.6 -1.5 -0.1 -1.8
Fasting Glucose 0.3 0.3 0.8 0.7 -0.7 0.0 -0.9 0.4 0.5 -0.2
HbA1C 0.2 0.2 0.6 -0.8 0.4 -0.5 -0.5 0.3 -0.4 0.2
HDL Cholesterol 0.6 1.1 3.2 -1.1 -0.8 1.8 0.2 0.7 -0.6 1.1
LDL Cholesterol 0.5 0.8 2.0 -1.0 1.0 -1.4 0.9 -0.8 -0.2 0.2
Lupus 1.2 1.8 5.7 -0.5 -0.9 0.7 -2.4 1.8 0.0 1.3
Neuroticism (2016) 0.4 0.5 1.4 0.9 -0.3 1.0 0.7 -0.4 1.2 -0.1
Primary Biliary Cirrhosis 0.3 0.4 0.8 0.3 0.8 -0.4 -0.6 -0.8 -0.9 -0.7
Rheumatoid Arthritis 0.3 0.4 1.8 0.5 -0.0 -0.4 0.5 -0.3 1.4 0.4
Schizophrenia (2014) 0.4 0.8 2.7 0.1 1.1 -0.9 -1.6 0.1 -0.5 -0.6
Triglycerides 0.7 1.2 3.7 -1.0 1.9 0.5 -0.7 1.1 -0.9 0.7
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 2.9 4.2 8.5 2.3 0.4 -2.8 0.9 -2.6 0.3 -2.9
Blood Eosinophil Count 1.1 8.2 19.9 3.3 -0.9 -2.9 2.0 -1.5 4.5 -3.4
Blood Platelet Count 2.6 29.9 53.0 2.9 2.0 -7.3 6.5 -6.5 4.7 -6.1
Blood Red Count 0.6 5.7 13.9 0.4 -0.2 -3.4 2.7 -3.7 0.6 -2.5
Blood White Count 2.0 14.6 26.6 2.1 1.1 -4.7 5.0 -5.2 3.1 -3.6
Heel T-Score 1.2 9.5 21.5 0.1 1.5 -4.6 4.1 -4.5 1.3 -1.8
BMI 0.5 2.9 11.8 -0.9 0.5 -0.2 -0.9 0.7 -3.4 2.4
Height 0.8 14.9 32.9 -1.8 -0.7 5.0 -4.2 5.7 -0.6 5.0
Waist Hip Ratio (WHR) 3.3 14.8 23.5 -1.1 -0.8 4.4 -4.7 4.4 -4.8 4.2
Systolic Blood Pressure 0.4 2.0 5.9 -1.1 2.4 0.4 2.2 -1.1 0.9 -0.5
Smoking Status 0.6 1.6 3.2 1.3 -1.4 -1.8 -0.5 -0.9 -0.3 -1.7
Allergy or Eczema 1.3 3.5 8.5 -2.4 -0.8 1.5 -1.4 2.9 0.6 2.2
Cardiovascular Disease 0.2 0.6 3.3 -0.5 0.4 0.1 0.6 -0.2 -1.8 -0.6
Hypothyroidism (self reported) 0.6 1.3 7.8 0.9 0.5 -0.0 0.3 0.3 2.8 -0.3
Respiratory disease 1.3 2.9 5.7 -0.8 -2.0 0.6 -2.4 2.0 -1.5 1.9
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.2 0.7 -0.8 -1.3 1.0 -0.9 0.6 -1.5
Lung FEV1/FVC ratio 0.8 3.9 9.6 -0.7 0.1 -2.5 3.0 -3.1 -0.9 -1.1
Lung FVC 1.0 4.9 10.6 -3.3 0.7 2.1 -0.9 2.8 -1.3 2.9
Neuroticism 0.8 1.8 4.2 1.7 -1.2 -1.1 0.8 -2.1 0.3 -1.5
Chronotype (morning person) 1.4 3.3 8.9 2.2 0.5 -1.3 3.0 -2.2 1.0 -1.3
Hair Pigment 0.0 1.0 2.6 1.0 -1.5 1.6 -0.9 0.7 -0.1 0.2
Tanning 0.1 0.8 2.4 0.8 -0.2 -1.6 0.5 -1.2 -0.2 -0.9
Hand grip strength (left) 0.9 2.5 4.9 0.1 -2.1 1.0 -2.0 2.2 -1.2 1.2
Number of treatments/medications taken 0.5 0.9 2.5 0.9 -0.9 -0.4 -0.3 -1.0 1.6 -0.8
Average weekly spirits intake 0.2 0.2 0.7 -0.8 0.6 0.2 0.4 0.1 -0.4 0.4
Sensitivity / hurt feelings 0.5 0.8 2.3 1.4 -1.5 -0.1 0.1 -0.6 0.2 -0.8
Frequency of depressed mood in last 2 weeks 1.9 2.6 4.3 1.8 -0.2 -1.3 2.1 -1.8 1.4 -2.0
Hearing difficulty/problems: Yes 0.6 0.8 2.1 1.5 -0.3 0.9 -1.4 0.9 -0.3 0.3
Relative age of first facial hair 1.6 3.2 6.8 -0.4 -1.1 2.6 -2.5 2.2 0.1 1.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.7 0.8 -1.3 0.2 -0.8 0.7 0.9 0.5
Ever used hormone-replacement therapy (HRT) 0.5 0.7 2.7 -0.5 -0.8 -0.0 1.6 -0.1 0.3 -1.0
Ever had hysterectomy (womb removed) 1.0 1.2 3.7 -1.9 -0.9 -0.2 1.8 -0.6 -0.2 0.3
Systolic blood pressure, automated reading 0.3 1.0 3.4 -1.3 1.9 -0.4 1.0 -0.6 -0.4 0.2
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.4 -0.6 -0.2 1.4 -1.6 1.3 -0.2 1.1
Angina 1.2 1.6 3.0 0.4 0.4 -1.7 1.0 -1.7 1.5 -1.5
Medication for hormone replacement therapy 0.2 0.3 0.7 -0.3 -0.8 -0.2 0.8 -0.1 -0.1 -0.6
Vitamin and mineral supplements 0.9 1.2 3.2 -0.8 0.7 1.0 -0.6 1.2 -1.0 1.8
Supplements: Zinc 2.7 2.9 7.4 1.3 -1.9 -1.9 0.2 -1.5 1.4 -2.7
Medication: Co-codamol 0.9 1.1 2.0 -1.4 1.0 0.6 -1.3 0.4 -0.7 1.4
Medication: Metformin 0.3 0.5 2.3 0.8 -1.5 0.2 0.1 0.0 0.6 -0.1
Diabetes (father) 0.5 0.6 2.6 -1.6 -0.6 0.1 1.2 0.2 -0.2 0.1
Diabetes (mother) 2.9 3.7 7.2 -2.0 -2.7 2.2 -1.5 1.6 -1.8 1.5
Severe depression (siblings) 0.9 1.1 3.7 1.9 -0.8 1.7 -0.1 0.4 0.3 0.3
Pack years adult smoking proportion 0.6 0.9 2.3 -1.0 -0.9 -1.5 0.4 -1.1 -0.9 -0.1
Impedance of leg (right) 1.1 5.3 9.3 0.3 0.1 -2.1 2.9 -3.0 2.4 -3.0
Leg fat-free mass (left) 1.9 10.1 20.2 -1.3 -1.0 3.1 -3.0 4.0 -3.5 4.5
Trunk fat percentage 0.5 1.9 6.1 -0.7 0.2 -0.9 0.8 -0.6 -2.3 2.5
Hand grip strength (right) 0.6 1.6 4.8 -0.1 -0.9 1.0 -1.6 2.2 -0.8 1.2
Townsend deprivation index at recruitment 0.8 1.2 3.0 0.5 1.5 -1.7 -0.2 -1.3 0.2 -1.0
Current tobacco smoking 0.6 0.9 4.4 -2.1 -0.3 -1.0 -0.7 0.2 -0.1 0.6
Average weekly fortified wine intake 0.9 1.1 2.0 0.9 0.8 -1.1 1.4 -1.0 1.2 -0.8
Maternal smoking around birth 1.8 2.7 5.7 -2.4 -1.1 1.1 -1.7 1.6 -2.0 1.1
Fed-up feelings 0.9 1.7 3.8 1.1 -0.0 -1.2 1.9 -2.0 0.6 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 2.2 3.0 6.4 1.1 1.2 -2.1 1.4 -2.2 0.9 -2.5
Relative age voice broke 0.9 1.4 4.3 0.8 -1.3 2.1 -0.9 1.5 0.3 0.6
Taking other prescription medications 0.9 1.3 3.6 1.6 -1.5 0.4 -1.9 0.2 0.4 0.9
Age when periods started (menarche) 0.6 1.5 3.3 0.1 -1.0 1.0 -1.1 1.8 1.0 1.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 2.2 -0.0 -0.4 -0.5 1.5 -0.4 0.1 0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.9 10.4 -0.2 1.1 -3.2 2.1 -2.7 0.8 -1.7
Tinnitus: Yes, but not now, but have in the past 2.6 2.8 5.2 0.6 -0.3 -2.3 1.5 -2.2 1.8 -1.9
Qualifications: CSEs or equivalent 0.1 0.2 0.7 -0.6 -0.3 -0.8 0.2 0.1 0.3 -0.2
Serious illness, injury or assault to yourself 1.2 1.5 3.7 0.5 -1.0 -1.9 0.5 -1.5 -0.2 -1.7
High blood pressure 0.1 0.2 0.6 -0.6 0.2 0.8 -0.5 0.3 0.4 0.2
Hayfever, allergic rhinitis or eczema 1.8 4.0 9.5 -1.7 -0.6 2.4 -2.0 3.1 0.5 2.4
Multivitamins +/- minerals 0.4 0.5 2.0 0.5 -1.4 -0.1 0.7 -0.6 0.2 -0.7
Stomach or abdominal pain in last month 0.6 0.8 4.3 0.6 -2.1 -0.5 -0.5 0.3 0.4 -0.1
Supplements: Glucosamine 0.5 0.6 2.6 1.6 0.0 0.8 -0.6 0.7 -0.6 0.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.0 0.2 -0.7 0.3 0.2 0.2 1.0 0.5
Medication: Atenolol 1.2 1.5 2.7 -0.1 0.3 -1.3 1.2 -1.6 1.4 -1.5
Medication: Levothyroxine sodium 1.0 1.7 9.8 0.4 0.3 -0.6 1.0 -0.8 3.1 -0.4
Sitting height 0.2 1.7 6.9 -0.1 0.4 1.1 -0.1 1.5 -1.2 2.6
Chronic bronchitis/emphysema (father) 0.9 1.1 3.4 -1.1 -1.0 0.7 -0.4 0.4 1.0 1.8
High blood pressure (mother) 0.8 1.1 3.8 -1.2 -1.9 -0.2 0.5 -0.3 1.4 0.6
Body mass index (BMI) 0.8 3.2 10.2 -1.0 0.1 0.5 -0.7 0.8 -3.2 3.1
Impedance of leg (left) 1.1 5.4 10.3 0.6 0.4 -2.4 2.8 -3.2 2.1 -3.0
Leg predicted mass (left) 1.9 10.2 20.6 -1.2 -1.0 3.2 -3.1 4.0 -3.5 4.5
Trunk fat mass 0.7 3.0 11.8 -0.9 -0.2 0.4 -0.2 0.7 -2.8 3.4
Waist circumference 2.0 7.5 18.1 -1.0 -1.0 2.3 -2.3 2.6 -3.9 4.2
Number of incorrect matches in round 3.9 6.5 12.9 1.8 -0.8 -2.3 3.0 -2.7 2.6 -3.6
Past tobacco smoking 1.3 2.4 6.5 -2.5 1.3 1.3 1.0 0.7 -0.3 2.3
Alcohol usually taken with meals 1.1 1.8 11.4 3.4 0.1 0.1 -0.1 -0.3 0.5 -0.8
Nervous feelings 2.1 4.0 6.6 1.8 -1.2 -1.9 1.9 -2.6 1.7 -2.5
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 4.5 0.2 0.3 -1.6 1.7 -1.2 2.1 -1.0
Hearing difficulty/problems with background noise 1.2 1.9 5.9 1.7 -0.8 -0.1 -2.4 0.8 1.5 -1.0
Hair/balding pattern: Pattern 2 1.2 1.6 3.5 1.9 -1.3 1.0 -1.7 1.2 -0.9 -0.2
Had menopause 0.6 0.8 1.8 1.3 -1.4 0.4 -0.7 0.0 -0.9 -0.9
Had other major operations 0.2 0.2 0.4 0.3 -0.7 0.1 -0.4 0.7 -0.6 -0.4
Forced vital capacity (FVC) 1.1 4.3 11.0 -1.2 -0.2 2.8 -2.0 3.3 -1.4 2.0
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 17.0 0.1 0.7 -4.1 2.9 -3.2 1.2 -2.0
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 4.6 1.6 1.2 -0.8 1.8 -2.1 1.3 -1.5
Qualifications: None of the above 2.6 5.6 13.9 0.4 0.1 -2.7 3.4 -3.7 1.4 -2.0
Financial difficulties in last 2 years 0.1 0.1 0.4 -0.6 -0.3 -0.0 0.1 0.0 -0.4 -0.6
Mouth/teeth dental problems 0.9 1.4 3.6 -1.4 0.9 -0.9 1.9 -1.1 0.6 -1.0
Heart attack 7.8 10.0 16.2 1.0 2.3 -3.6 3.8 -4.0 2.7 -3.6
Allergy 2.4 5.5 11.5 0.9 1.7 -2.5 3.3 -3.4 0.0 -2.6
Pain all over the body in last month 0.3 0.4 1.0 0.5 1.0 -0.3 0.5 -1.0 0.1 -0.2
Diabetes (self-reported) 1.0 1.6 3.9 2.0 -0.5 -1.1 0.7 -1.4 0.4 -1.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.5 1.5 -1.2 -0.8 0.4 -0.0 0.2 0.2 0.9
Medication: Ramipril 0.9 1.1 2.1 -0.7 1.4 0.8 1.1 0.8 1.5 0.8
Medication: Simvastatin 1.1 1.6 3.5 0.3 0.6 -1.1 1.7 -1.4 1.1 -1.9
Fluid intelligence score 4.1 8.5 17.1 -2.0 -0.3 4.1 -4.0 3.9 -0.7 2.6
Illnesses of siblings 0.8 1.1 2.4 1.6 1.0 0.3 -1.3 -0.0 -1.5 0.2
Neuroticism score 1.5 3.0 6.3 1.5 -0.5 -1.9 1.1 -2.4 1.2 -2.5
Weight 1.3 6.3 18.4 -1.0 -0.2 1.9 -1.7 2.5 -3.5 4.3
Impedance of arm (right) 0.8 3.9 7.0 0.7 -0.6 -1.4 2.6 -2.1 2.5 -2.6
Arm fat percentage (right) 0.6 2.2 7.5 -0.7 -0.3 -0.0 0.2 0.1 -2.7 2.7
Trunk fat-free mass 1.6 9.5 16.6 -0.6 -0.8 3.6 -3.4 4.1 -2.9 4.0
Hip circumference 0.4 1.8 8.5 -0.8 -0.8 0.5 0.2 0.7 -1.5 2.9
Time employed in main current job 0.8 0.9 2.0 1.0 1.2 -0.9 -0.2 -1.1 -0.4 -1.4
Alcohol intake versus 10 years previously 0.9 1.4 3.1 -1.5 -1.8 1.4 -0.7 0.9 1.1 0.2
Father’s age at death 2.2 3.0 7.3 -0.9 -0.0 2.6 -0.9 2.1 -0.9 2.7
Worrier / anxious feelings 1.0 1.8 3.9 1.4 -1.2 -0.3 2.0 -1.3 1.4 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.3 1.1 -0.3 -0.3 -0.3 0.1 0.9 0.3
Falls in the last year 0.1 0.1 0.2 0.5 0.3 0.1 0.1 0.0 0.3 -0.3
Hair/balding pattern: Pattern 3 0.3 0.4 1.4 -0.6 -0.1 0.5 -0.8 -0.2 1.2 0.2
Number of live births 0.5 0.7 1.9 1.2 0.7 0.1 0.4 -0.8 -1.4 -0.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.5 -0.8 -0.0 1.6 -0.2 1.4 -1.6 1.3
Pulse rate 0.9 1.5 4.6 -0.1 -0.2 1.5 -1.1 0.7 -2.1 1.3
Happiness 0.3 0.3 0.8 0.7 -0.3 0.6 -0.5 0.2 0.4 -0.9
Noisy workplace 0.3 0.4 1.0 0.4 0.4 -0.5 1.0 -0.6 0.8 -0.5
Qualifications: A levels/AS levels or equivalent 3.5 7.8 17.1 -1.8 -1.2 3.5 -3.6 4.1 -1.7 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.9 0.3 -0.2 1.1 0.3 0.7 1.4 0.5
Mouth/teeth dental problems: Dentures 0.2 0.3 0.5 0.5 0.4 -0.5 -0.1 -0.5 -0.6 0.7
Asthma 1.6 3.2 7.1 0.3 -1.6 1.3 -2.7 2.2 -1.4 2.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.0 1.0 -0.9 0.3 -0.9 0.0 -0.5 -0.7
Medication: Cholesterol lowering 0.4 0.7 1.9 0.1 -0.5 0.2 1.2 -0.5 1.4 -0.8
Depression (self-reported) 0.6 0.7 3.4 0.6 0.9 -0.3 0.6 -0.4 1.8 -0.0
Medication: Lansoprazole 0.4 0.5 1.5 0.3 -0.2 -0.8 0.5 -1.2 0.7 -0.7
Prospective memory result 1.8 2.2 8.2 -2.9 1.6 -1.0 1.8 -0.3 -0.5 -0.2
Lung cancer (father) 2.4 2.8 9.2 1.0 -1.1 -3.0 0.9 -2.1 0.7 -1.7
Illnesses of mother 0.3 0.4 1.3 -0.6 1.1 0.4 -0.4 0.8 -0.5 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.4 -0.6 0.3 1.5 0.1 1.2 -1.4 1.4
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 -0.1 -0.1 1.4 -0.7 0.8 -1.3 0.6
Impedance of arm (left) 0.6 2.8 5.9 1.2 -0.6 -1.2 1.9 -1.7 2.4 -2.0
Arm fat mass (right) 0.8 3.5 12.2 -0.8 -0.1 0.8 -0.7 1.1 -3.0 3.5
Trunk predicted mass 1.7 9.6 16.7 -0.5 -0.8 3.6 -3.5 4.1 -2.9 4.0
Standing height 0.5 4.5 11.3 0.1 -0.8 3.1 -1.9 3.4 -0.5 2.5
Length of working week for main job 1.2 1.4 4.2 1.3 0.1 -2.1 0.6 -1.4 -0.1 -1.0
Exposure to tobacco smoke at home 1.1 1.2 3.6 -0.7 0.8 -1.0 1.9 -1.3 0.4 -0.9
Breastfed as a baby 0.5 0.6 1.3 0.1 0.8 -0.7 0.8 -0.4 0.9 -1.1
Tense / ‘highly strung’ 1.5 2.5 4.3 -0.1 -1.3 -2.1 1.3 -2.0 1.9 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 6.6 1.2 -1.3 -0.3 2.2 -1.2 2.6 -1.5
Hair/balding pattern: Pattern 4 0.5 1.1 3.3 -0.8 -1.4 -0.8 1.8 -0.7 -0.5 -0.6
Birth weight of first child 2.4 4.4 9.2 -0.5 -2.0 1.9 -2.3 3.0 -1.8 2.3
Peak expiratory flow (PEF) 0.3 0.7 2.2 0.4 0.3 -0.6 1.5 -1.1 -0.6 -0.4
Pulse wave reflection index 0.3 0.4 1.1 -0.4 0.1 0.4 1.0 -0.6 0.9 -0.5
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.9 0.3 0.8 0.6 0.1 0.4 -0.4 -1.0
Loud music exposure frequency 0.6 0.7 1.4 -0.2 0.2 -0.9 1.2 -1.0 -0.8 -0.8
Qualifications: O levels/GCSEs or equivalent 2.8 4.5 10.8 -0.9 -0.4 3.3 -1.9 3.3 -0.8 2.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.4 3.3 1.8 -1.2 0.4 -1.8 0.6 -1.0 -0.3
Blood clot in the leg (DVT) 0.6 0.7 2.6 1.6 -0.7 -0.4 -0.6 -1.0 -0.0 -0.6
Medication: Paracetamol 1.0 1.6 5.0 0.7 -0.3 1.5 -2.2 0.8 -0.6 1.5
Headache pain in last month 3.5 6.1 12.5 -0.6 -1.6 2.8 -3.1 3.5 -1.7 2.5
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.7 0.7 0.4 -0.0 -0.9 0.6 -1.9 1.1
Glaucoma (self-reported) 0.6 0.7 1.6 -1.2 -1.3 -0.9 -0.9 0.3 -0.2 0.0
Gout (self-reported) 4.5 6.2 12.7 -1.9 1.6 3.6 -1.4 2.8 -2.2 3.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 8.0 0.5 1.1 -0.2 0.2 -0.3 2.8 0.1
Medication: Amlodipine 0.8 1.1 4.1 0.7 0.9 -0.1 1.2 -1.0 2.0 -0.0
Medication: Ventolin 100micrograms inhaler 6.3 8.1 16.0 -1.4 -1.2 2.8 -3.6 4.0 -1.2 3.9
Birth weight 3.0 6.5 10.2 -0.5 -0.5 3.0 -3.2 3.2 -2.8 2.9
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 0.7 -0.7 -0.0 -0.3 -0.1 0.2 0.8
High blood pressure (siblings) 0.8 1.2 4.8 -2.2 -0.7 0.1 0.5 0.8 1.1 0.9
Forced vital capacity (FVC), Best measure 0.8 2.9 6.9 -0.8 0.5 2.4 -1.2 2.6 -1.1 2.0
Body fat percentage 0.5 2.0 6.0 -0.8 0.1 -0.7 0.8 -0.6 -2.4 2.4
Leg fat percentage (right) 0.5 1.8 5.7 -0.8 0.2 -1.0 1.1 -1.1 -2.4 1.6
Arm fat-free mass (right) 1.6 8.3 18.0 -1.0 -0.4 3.0 -2.9 3.3 -3.2 4.2
Exposure to tobacco smoke outside home 1.5 2.0 5.5 2.3 1.1 -0.8 0.9 -1.7 -0.0 -1.8
Comparative body size at age 10 0.2 0.7 2.6 0.6 0.2 -1.0 -0.7 -0.0 -1.6 -0.3
Number of full brothers 0.9 1.2 3.3 -0.8 -0.1 1.8 -1.2 1.6 -0.1 0.7
Worry too long after embarrassment 1.0 1.7 5.2 1.2 -0.9 -1.5 -0.8 -1.0 0.8 -2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.6 1.2 -1.0 -0.5 0.6 -0.9 0.3 -0.4
Wheeze or whistling in the chest in last year 1.0 1.7 7.4 -0.9 -2.7 -0.1 -1.4 0.8 -0.3 1.1
Number of children fathered 1.6 1.8 5.3 -0.1 0.5 1.6 -0.4 1.3 -1.6 2.3
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.5 0.7 -0.4 -1.9 1.3 -1.5 1.3 -0.7
Age at first live birth 0.7 1.2 5.2 0.3 1.1 1.0 0.5 0.5 2.3 -0.6
Pulse wave peak to peak time 0.6 0.7 2.1 0.0 0.2 -1.4 0.7 -0.7 1.2 -0.6
Health satisfaction 0.5 0.7 1.6 1.3 -1.0 -0.4 0.7 -0.5 0.4 -1.1
Shortness of breath walking on level ground 0.2 0.2 0.5 0.4 -0.7 0.4 -0.6 0.4 -0.0 0.1
Qualifications: College or University degree 1.8 5.7 13.6 -0.2 -1.3 3.7 -2.7 3.7 -1.3 1.4
Eye problems/disorders: None of the above 0.2 0.2 0.6 -0.4 -0.8 -0.3 0.7 -0.2 -0.1 -0.2
Mouth/teeth dental problems: Loose teeth 1.5 1.7 5.8 0.8 2.4 -0.0 -0.1 -0.3 2.3 -0.6
Emphysema/chronic bronchitis 1.6 1.8 5.7 -1.0 -2.1 -0.2 -2.4 0.9 0.2 0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 1.2 -1.1 1.0 -0.2 0.7 0.5 0.5 -0.1
Neck or shoulder pain in last month 0.7 1.0 1.8 1.3 -0.2 -1.3 -1.3 -0.3 0.2 -1.2
Medication: Blood pressure 0.7 1.3 4.3 -0.4 -0.7 -0.0 1.2 -0.9 2.1 -1.4
Angina (self-reported) 1.2 1.6 2.8 0.6 0.7 -1.5 1.0 -1.7 1.6 -1.3
Migraine (self-reported) 0.4 0.4 1.0 -0.9 -0.7 0.6 -0.3 0.3 0.6 1.0
Medication: Ibuprofen 0.4 0.5 2.1 1.4 -0.1 0.8 -0.7 0.2 0.1 -0.2
Medication: Allopurinol 1.2 1.6 5.1 -1.0 0.6 2.2 -0.9 1.4 -0.3 1.4
Medication: Omeprazole 0.4 0.4 1.2 -1.1 -0.8 -0.3 -0.4 0.3 -0.7 0.7
Medication: Seretide 50 evohaler 0.5 0.6 1.9 0.8 -0.6 0.4 -1.4 0.7 0.2 0.5
Mean time to correctly identify matches 2.0 3.7 10.1 0.3 1.1 -0.7 3.2 -1.4 2.2 -2.7
Heart disease (mother) 1.6 1.9 5.7 -0.6 0.9 -1.0 2.0 -1.2 2.4 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.9 -0.5 -0.4 -0.6 0.9 -0.7 -0.2 -0.7
Whole body fat mass 0.8 3.2 11.4 -1.1 -0.2 0.6 -0.3 0.8 -3.0 3.4
Leg fat mass (right) 0.9 3.5 11.2 -1.3 -0.1 0.4 -0.5 0.8 -3.3 3.2
Arm predicted mass (right) 1.6 8.4 17.7 -0.8 -0.3 2.9 -3.0 3.4 -3.3 4.2
Pulse rate, automated reading 0.9 2.9 8.6 -0.5 0.6 2.3 -1.0 0.9 -2.9 2.0
Alcohol intake frequency. 0.5 1.3 6.8 -2.6 0.3 0.6 -0.4 0.3 -0.2 1.2
Comparative height size at age 10 0.3 1.8 4.7 0.8 0.1 2.2 -0.4 1.5 -1.0 2.0
Number of full sisters 0.9 1.1 4.0 0.9 0.2 -0.2 -0.1 -0.7 2.0 -1.6
Suffer from ‘nerves’ 2.0 3.1 5.5 2.1 -0.6 -2.3 1.4 -2.0 1.3 -2.0
Overall health rating 0.3 0.6 1.8 0.7 -1.1 -1.3 -0.6 -0.5 0.1 -0.4
Chest pain or discomfort 0.6 0.9 4.9 0.1 0.3 -0.3 1.0 -0.6 2.2 -0.0
Had major operations 2.4 2.8 5.6 -1.5 0.6 1.9 -1.4 1.8 -1.5 2.4
Age at last live birth 0.8 1.2 6.8 -0.1 2.6 0.8 -0.1 0.8 0.5 -0.2
Family relationship satisfaction 0.3 0.3 1.1 0.2 0.6 0.0 -0.9 0.0 0.2 -1.0
Leg pain on walking 0.9 1.1 2.6 0.7 1.5 -0.1 1.6 -0.8 0.1 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.1 -0.2 -0.8 -0.2 -0.0 0.2 1.1 0.6
Commuting to job workplace: Car/motor vehicle 2.8 3.2 8.7 -1.1 -1.4 1.7 -1.5 1.8 -2.9 1.7
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 1.8 -0.9 1.1 0.2 -1.3 0.9 -0.1 1.0
Medication: Aspirin 1.3 1.7 3.8 1.6 -0.5 -1.0 1.2 -2.0 0.5 -1.7
Supplements: Vitamin C 0.6 0.7 1.7 -0.1 -1.0 -1.0 -1.1 -0.4 -0.2 -1.3
Knee pain experienced in last month 0.3 0.5 1.9 -0.5 1.4 0.8 0.4 0.5 0.0 0.8
Hypertension (Self-reported) 0.2 0.5 1.6 -0.9 0.5 1.3 -0.4 0.5 0.4 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.2 -1.6 0.5 0.6 -1.0 1.1 -0.2 1.8
Illnesses of father: Heart disease 10.8 14.9 26.1 3.7 1.1 -4.0 5.1 -4.6 2.1 -4.6
Illnesses of siblings: Diabetes 0.4 0.5 1.5 -0.2 -1.2 0.7 -0.5 0.7 -0.7 -0.1
Smoking status: Previous 1.4 2.1 9.1 3.0 0.1 -0.9 -0.3 -1.0 0.3 -2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.4 -1.4 -0.3 1.9 0.2 1.7 -0.6 1.3
Whole body fat-free mass 1.8 10.2 18.4 -0.8 -1.0 3.4 -3.4 4.1 -3.4 4.3
Leg fat-free mass (right) 2.0 10.5 20.3 -1.0 -0.7 3.2 -3.4 4.1 -3.6 4.5
Arm fat percentage (left) 0.6 2.3 7.8 -0.3 -0.4 -0.2 0.0 0.0 -2.8 2.8
Average weekly red wine intake 0.6 0.9 1.4 1.2 0.5 0.6 -1.1 1.2 -1.1 0.5
Handedness (chirality/laterality): Left-handed 0.8 1.0 5.5 0.5 2.3 0.3 -0.9 0.0 0.6 0.4
Mood swings 0.9 1.6 4.0 0.3 -0.1 -0.8 1.8 -2.0 0.5 -1.9
Loneliness, isolation 2.5 3.5 7.0 1.4 1.0 -2.0 2.1 -2.6 1.3 -2.2
Long-standing illness, disability or infirmity 0.7 1.0 2.6 1.5 -1.1 0.8 -0.3 -0.3 1.6 -0.3
Ever had bowel cancer screening 0.3 0.3 0.5 0.3 -0.7 0.7 -0.7 0.4 -0.1 0.7
Diabetes diagnosed by doctor 0.7 1.1 3.2 0.9 -0.7 -0.9 0.9 -1.2 0.6 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.5 -0.1 0.2 0.6 -0.6 0.2 0.7 -0.2
Friendships satisfaction 0.2 0.3 0.6 -0.8 0.0 0.8 -0.6 0.6 0.2 -0.3
Qualifications: nursing, teaching 1.1 1.7 3.6 -0.8 0.8 1.9 -1.0 1.9 -0.2 1.5
Commuting to job workplace: Walk 0.9 1.0 3.3 -0.2 1.6 -0.5 0.8 -0.3 1.8 -0.4
Eye problems/disorders: Cataract 0.4 0.4 1.0 0.6 0.0 0.7 -1.0 0.9 -0.2 0.6
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 6.1 -0.7 -1.6 1.5 -1.9 2.5 -0.5 1.4
Medication for cholesterol 1.1 1.7 5.1 1.2 -2.3 0.7 -1.8 1.2 0.5 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.0 0.2 0.6 -1.0 0.5 -1.4 -0.7 -0.3
Back pain experienced in last month 0.6 0.8 2.9 0.8 -1.7 -1.4 -0.3 -0.3 -0.4 -0.4
Mineral and other dietary supplements 0.2 0.2 1.1 -1.0 0.4 -0.5 0.1 0.4 0.0 0.2
Breast cancer (self-reported) 0.3 0.4 1.0 0.6 -0.5 1.0 0.0 -0.2 -0.9 0.3
Asthma (self-reported) 1.7 3.4 6.3 0.1 -1.9 1.4 -2.5 2.4 -1.3 2.1
Osteoporosis (self-reported) 0.3 0.4 2.4 -0.0 -0.1 -0.2 0.5 0.1 1.6 0.2
Osteoarthritis (self-reported) 0.6 0.8 1.3 1.0 0.5 -0.7 1.0 -1.1 -0.5 -1.0
Medication: Aspirin 1.3 1.6 3.7 1.5 -0.8 -0.9 1.3 -1.9 0.1 -1.6
Medication: Gliclazide 0.7 0.8 3.3 1.2 -1.8 0.7 -0.1 0.7 0.1 -0.1
Illnesses of father: None of the above (group 1) 3.3 4.0 13.5 -1.0 -0.4 1.8 -3.7 2.5 -0.6 1.9
Smoking status: Current 0.5 0.7 3.1 -1.8 -0.7 -0.8 -0.6 0.2 -0.3 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 6.2 -1.3 2.5 0.8 1.6 -0.2 -0.0 0.8
Whole body water mass 1.8 10.4 19.6 -0.8 -0.9 3.5 -3.4 4.1 -3.3 4.4
Leg predicted mass (right) 2.0 10.5 20.4 -1.0 -0.9 3.1 -3.4 4.1 -3.6 4.5
Arm fat mass (left) 0.8 3.5 12.1 -0.5 -0.4 0.8 -0.8 1.1 -3.1 3.5
Number of self-reported non-cancer illnesses 0.9 1.6 2.9 0.1 -1.6 1.3 -1.2 0.9 1.7 1.3
Average weekly champagne plus white wine intake 1.3 1.7 5.8 2.4 -0.2 -0.7 0.5 -1.4 0.4 -1.8
Miserableness 2.4 4.2 9.2 -0.1 -0.1 -1.9 2.5 -2.7 3.0 -1.8
Guilty feelings 1.3 2.0 4.9 1.0 -0.5 -1.9 -0.1 -2.2 0.1 -2.1
Wears glasses or contact lenses 0.5 0.6 1.5 -0.6 0.9 0.2 1.2 0.0 1.2 0.2
Ever taken oral contraceptive pill 0.8 0.9 1.6 0.1 1.3 -1.0 0.8 -0.7 1.1 -1.1
Hearing aid user 0.6 0.7 1.7 -0.2 1.3 0.9 0.3 1.2 0.0 0.9
Mother’s age at death 1.8 2.3 4.0 0.8 -0.5 1.7 -2.0 2.0 -1.6 1.2
Financial situation satisfaction 1.8 2.3 5.2 0.7 0.4 -1.6 1.9 -2.3 0.5 -1.9
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 -0.2 -0.1 0.2 0.3 -0.1 -0.1 -0.6
Commuting to job workplace: Public transport 0.2 0.3 0.5 0.6 -0.6 -0.7 0.1 -0.5 0.5 -0.3
Eye problems/disorders: Glaucoma 1.0 1.1 3.3 -1.7 -1.8 -0.1 -1.0 0.4 -0.7 0.2
Medication: Blood pressure 0.9 1.6 5.5 -0.6 2.3 -0.2 1.8 -1.3 0.7 -0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.5 1.2 -0.2 -0.5 -0.6 -0.2 0.9 0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.6 -0.5 -0.1 1.6 -0.5 0.6 -0.0 1.4
High cholesterol (Self-reported) 0.5 0.9 2.0 -0.7 1.4 -0.7 1.4 -0.5 0.6 -0.6
Medication: Bendroflumethiazide 1.0 1.6 4.9 -1.6 2.2 -0.3 1.1 -0.9 1.2 -0.1
Medication: Paracetamol 1.9 2.9 5.9 0.4 0.2 2.4 -2.4 1.7 -0.7 2.2
Medication: Lisinopril 3.3 4.3 9.2 1.9 1.4 -2.5 1.5 -3.0 0.9 -2.4
Medication: Atorvastatin 0.2 0.2 0.7 0.2 0.7 -0.4 0.8 -0.4 0.2 -0.2
Illnesses of father: High blood pressure 0.8 1.0 3.3 1.2 -1.8 1.1 0.1 0.7 -1.0 0.1
Alcohol drinker status: Never 0.8 0.9 4.0 -2.0 -0.2 0.2 1.0 -0.2 0.8 0.8
Ever smoked 2.0 3.5 8.3 2.9 -2.0 -1.5 -1.8 -0.3 0.7 -2.5
Basal metabolic rate 1.8 9.8 20.2 -1.0 -0.8 3.2 -3.1 3.9 -3.5 4.5
Leg fat percentage (left) 0.5 1.8 6.4 -0.4 0.4 -1.2 0.9 -1.2 -2.5 1.6
Arm fat-free mass (left) 1.5 7.9 15.5 -1.1 -0.1 2.7 -2.8 3.3 -3.4 3.9
Number of operations (self-reported) 2.9 4.3 7.1 0.0 -2.3 1.9 -2.3 2.4 -2.7 1.6
Average weekly beer plus cider intake 1.0 1.5 6.6 -2.6 -0.5 0.0 0.4 -0.3 -1.7 0.7
Irritability 0.3 0.6 2.1 0.3 -1.0 0.4 0.3 -0.6 -0.1 -1.5
Risk taking 0.7 1.0 3.0 -1.0 1.7 -0.9 0.8 -0.6 0.5 -0.8
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.5 0.7 -0.3 0.4 -0.7 0.7 -0.6 0.0
Fractured/broken bones in last 5 years 0.6 0.8 2.5 0.1 -1.2 1.6 -0.9 1.0 0.1 0.0
Age started oral contraceptive pill 0.8 1.0 3.1 0.1 0.4 -0.8 1.6 -0.6 1.8 0.4
Diastolic blood pressure, automated reading 1.7 5.1 9.5 -2.8 1.8 2.5 -0.2 2.0 -2.2 3.1
Ever depressed for a whole week 1.3 1.7 5.8 1.6 0.6 -0.8 1.0 -0.9 2.4 -0.7
Unable to work because of sickness or disability 0.1 0.2 0.4 0.4 0.5 -0.4 -0.7 0.1 0.4 0.4
Commuting to job workplace: Cycle 1.4 1.6 6.9 1.6 -0.1 0.5 0.5 -0.8 2.6 -1.0
Myopia 0.3 0.4 1.5 -0.6 0.8 -0.2 0.2 0.3 1.2 -0.1
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.7 0.5 -0.3 0.2 -0.1 0.7 -0.9 0.7
Cholesterol lowering medication 1.0 1.4 3.3 -0.3 1.8 -1.3 1.7 -1.2 0.3 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.5 -0.4 0.1 -0.3 -0.5 0.2 -1.2 0.6
Pain experienced in last month 0.5 0.9 1.8 -0.8 0.6 -0.7 1.3 -1.0 1.2 -0.8
Supplements: Calcium 1.6 1.8 8.4 0.7 -2.9 -0.5 -1.4 0.3 0.6 -1.0
Basal cell carcinoma (self-reported) 2.1 2.5 8.9 0.9 -1.2 1.7 -1.7 0.8 -3.0 0.4
Heart attack/myocardial infarction (self-reported) 7.9 10.2 16.9 1.2 2.2 -3.4 3.9 -4.1 2.9 -3.6
Deep venous thrombosis (DVT) (self-reported) 1.0 1.2 3.8 2.0 -0.9 -1.0 -0.3 -1.4 0.1 -0.9
Heart disease (siblings) 1.8 2.2 5.0 0.0 1.1 -1.7 1.5 -1.7 0.9 -2.2
Alcohol drinker status: Previous 0.4 0.5 1.4 -1.2 -0.2 0.9 -0.2 0.2 0.6 0.9
Pack years of smoking 0.7 1.0 3.3 -0.7 -0.7 -1.8 0.7 -1.4 -0.5 -0.3
Impedance of whole body 0.9 4.5 7.3 0.5 -0.3 -2.0 2.6 -2.6 2.5 -2.7
Leg fat mass (left) 0.9 3.6 13.0 -1.1 -0.1 0.4 -0.6 0.7 -3.6 3.1
Arm predicted mass (left) 1.6 8.3 15.8 -1.1 -0.5 3.0 -3.1 3.5 -3.2 4.0