TWAS hub - FCHO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0320	1.4e-02	0.027	0.033	0.030	0.040	0.043	2.6e-04	5.9e-05	1.3e-04	9.7e-06	4.9e-06
2	GTEx	Brain Cerebellum	0.3950	0.1180	9.4e-03	0.183	NA	0.114	NA	0.159	4.4e-06	NA	3.0e-04	NA	2.0e-05
3	GTEx	Nerve Tibial	0.2091	0.0561	3.8e-04	0.044	NA	0.065	NA	0.053	4.2e-04	NA	2.3e-05	NA	1.3e-04
4	GTEx	Whole Blood	0.1510	0.0370	3.1e-05	0.114	NA	0.085	NA	0.091	1.2e-10	NA	3.1e-08	NA	9.6e-09
5	METSIM	Adipose	0.0459	0.0185	6.6e-03	0.030	0.012	0.029	0.024	0.038	2.0e-05	4.7e-03	2.7e-05	1.2e-04	2.1e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.1133	0.0330	1.5e-04	0.040	0.035	0.064	0.048	0.027	5.8e-06	2.0e-05	1.3e-08	7.7e-07	1.9e-04
7	YFS	Blood	0.0951	0.0178	1.7e-16	0.069	0.053	0.067	0.068	0.067	1.5e-21	6.7e-17	5.5e-21	2.0e-21	4.8e-21

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Illnesses of father: Heart disease	10.8	14.9	26.1	3.7	1.1	-4.0	5.1	-4.6	2.1	-4.6
Heart attack/myocardial infarction (self-reported)	7.9	10.2	16.9	1.2	2.2	-3.4	3.9	-4.1	2.9	-3.6
Heart attack	7.8	10.0	16.2	1.0	2.3	-3.6	3.8	-4.0	2.7	-3.6
Medication: Ventolin 100micrograms inhaler	6.3	8.1	16.0	-1.4	-1.2	2.8	-3.6	4.0	-1.2	3.9
Gout (self-reported)	4.5	6.2	12.7	-1.9	1.6	3.6	-1.4	2.8	-2.2	3.1
Fluid intelligence score	4.1	8.5	17.1	-2.0	-0.3	4.1	-4.0	3.9	-0.7	2.6
Verbal and Numeric Reasoning (VNR)	3.9	9.4	18.7	-2.4	-0.9	4.3	-4.2	4.1	-1.3	2.1
Number of incorrect matches in round	3.9	6.5	12.9	1.8	-0.8	-2.3	3.0	-2.7	2.6	-3.6
Qualifications: A levels/AS levels or equivalent	3.5	7.8	17.1	-1.8	-1.2	3.5	-3.6	4.1	-1.7	2.2
Headache pain in last month	3.5	6.1	12.5	-0.6	-1.6	2.8	-3.1	3.5	-1.7	2.5
Irritable Bowel Disease (IBD)	3.3	7.9	14.2	2.9	0.7	-3.8	2.1	-3.6	1.4	-3.6
Waist Hip Ratio (WHR)	3.3	14.8	23.5	-1.1	-0.8	4.4	-4.7	4.4	-4.8	4.2
Illnesses of father: None of the above (group 1)	3.3	4.0	13.5	-1.0	-0.4	1.8	-3.7	2.5	-0.6	1.9
Medication: Lisinopril	3.3	4.3	9.2	1.9	1.4	-2.5	1.5	-3.0	0.9	-2.4
Intelligence (Savage-Jansen 2018)	3.0	9.1	19.8	-2.8	-1.5	4.5	-3.4	3.9	-0.9	2.5
Birth weight	3.0	6.5	10.2	-0.5	-0.5	3.0	-3.2	3.2	-2.8	2.9
Ulcerative Colitis	2.9	4.2	8.5	2.3	0.4	-2.8	0.9	-2.6	0.3	-2.9
Diabetes (mother)	2.9	3.7	7.2	-2.0	-2.7	2.2	-1.5	1.6	-1.8	1.5
Number of operations (self-reported)	2.9	4.3	7.1	0.0	-2.3	1.9	-2.3	2.4	-2.7	1.6
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	10.8	-0.9	-0.4	3.3	-1.9	3.3	-0.8	2.3
Commuting to job workplace: Car/motor vehicle	2.8	3.2	8.7	-1.1	-1.4	1.7	-1.5	1.8	-2.9	1.7
Supplements: Zinc	2.7	2.9	7.4	1.3	-1.9	-1.9	0.2	-1.5	1.4	-2.7
Ulcerative Colitis (UC)	2.6	4.9	9.5	2.1	0.1	-3.0	1.6	-2.9	0.7	-3.1
Blood Platelet Count	2.6	29.9	53.0	2.9	2.0	-7.3	6.5	-6.5	4.7	-6.1
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	5.2	0.6	-0.3	-2.3	1.5	-2.2	1.8	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	17.0	0.1	0.7	-4.1	2.9	-3.2	1.2	-2.0
Qualifications: None of the above	2.6	5.6	13.9	0.4	0.1	-2.7	3.4	-3.7	1.4	-2.0
Depression (Nagel 2018)	2.5	3.8	7.2	1.3	-0.1	-2.4	2.2	-2.4	1.2	-2.7
Loneliness, isolation	2.5	3.5	7.0	1.4	1.0	-2.0	2.1	-2.6	1.3	-2.2
Allergy	2.4	5.5	11.5	0.9	1.7	-2.5	3.3	-3.4	0.0	-2.6
Lung cancer (father)	2.4	2.8	9.2	1.0	-1.1	-3.0	0.9	-2.1	0.7	-1.7
Birth weight of first child	2.4	4.4	9.2	-0.5	-2.0	1.9	-2.3	3.0	-1.8	2.3
Had major operations	2.4	2.8	5.6	-1.5	0.6	1.9	-1.4	1.8	-1.5	2.4
Miserableness	2.4	4.2	9.2	-0.1	-0.1	-1.9	2.5	-2.7	3.0	-1.8
Crohns Disease (2017)	2.2	4.8	8.9	2.1	1.0	-3.0	1.8	-2.6	1.8	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	6.4	1.1	1.2	-2.1	1.4	-2.2	0.9	-2.5
Father’s age at death	2.2	3.0	7.3	-0.9	-0.0	2.6	-0.9	2.1	-0.9	2.7
Nervous feelings	2.1	4.0	6.6	1.8	-1.2	-1.9	1.9	-2.6	1.7	-2.5
Basal cell carcinoma (self-reported)	2.1	2.5	8.9	0.9	-1.2	1.7	-1.7	0.8	-3.0	0.4
Worry (Nagel 2018)	2.0	4.3	5.6	2.3	-1.9	-2.0	1.8	-2.4	2.0	-2.1
Blood White Count	2.0	14.6	26.6	2.1	1.1	-4.7	5.0	-5.2	3.1	-3.6
Waist circumference	2.0	7.5	18.1	-1.0	-1.0	2.3	-2.3	2.6	-3.9	4.2
Mean time to correctly identify matches	2.0	3.7	10.1	0.3	1.1	-0.7	3.2	-1.4	2.2	-2.7
Suffer from ‘nerves’	2.0	3.1	5.5	2.1	-0.6	-2.3	1.4	-2.0	1.3	-2.0
Leg fat-free mass (right)	2.0	10.5	20.3	-1.0	-0.7	3.2	-3.4	4.1	-3.6	4.5
Leg predicted mass (right)	2.0	10.5	20.4	-1.0	-0.9	3.1	-3.4	4.1	-3.6	4.5
Ever smoked	2.0	3.5	8.3	2.9	-2.0	-1.5	-1.8	-0.3	0.7	-2.5
Depressed Affect (Nagel 2018)	1.9	4.0	10.2	0.4	-0.5	-2.0	2.6	-3.2	1.5	-2.0
Reaction Time	1.9	3.6	9.7	0.1	0.6	-0.9	2.9	-1.0	2.2	-3.1
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.3	1.8	-0.2	-1.3	2.1	-1.8	1.4	-2.0
Leg fat-free mass (left)	1.9	10.1	20.2	-1.3	-1.0	3.1	-3.0	4.0	-3.5	4.5
Leg predicted mass (left)	1.9	10.2	20.6	-1.2	-1.0	3.2	-3.1	4.0	-3.5	4.5
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.6	1.6	1.2	-0.8	1.8	-2.1	1.3	-1.5
Medication: Paracetamol	1.9	2.9	5.9	0.4	0.2	2.4	-2.4	1.7	-0.7	2.2
Neuroticism (Nagel 2018)	1.8	4.2	8.1	1.4	-1.9	-2.0	1.6	-2.8	1.4	-2.7
Maternal smoking around birth	1.8	2.7	5.7	-2.4	-1.1	1.1	-1.7	1.6	-2.0	1.1
Hayfever, allergic rhinitis or eczema	1.8	4.0	9.5	-1.7	-0.6	2.4	-2.0	3.1	0.5	2.4
Prospective memory result	1.8	2.2	8.2	-2.9	1.6	-1.0	1.8	-0.3	-0.5	-0.2
Qualifications: College or University degree	1.8	5.7	13.6	-0.2	-1.3	3.7	-2.7	3.7	-1.3	1.4
Whole body fat-free mass	1.8	10.2	18.4	-0.8	-1.0	3.4	-3.4	4.1	-3.4	4.3
Whole body water mass	1.8	10.4	19.6	-0.8	-0.9	3.5	-3.4	4.1	-3.3	4.4
Mother’s age at death	1.8	2.3	4.0	0.8	-0.5	1.7	-2.0	2.0	-1.6	1.2
Financial situation satisfaction	1.8	2.3	5.2	0.7	0.4	-1.6	1.9	-2.3	0.5	-1.9
Basal metabolic rate	1.8	9.8	20.2	-1.0	-0.8	3.2	-3.1	3.9	-3.5	4.5
Heart disease (siblings)	1.8	2.2	5.0	0.0	1.1	-1.7	1.5	-1.7	0.9	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	10.4	-0.2	1.1	-3.2	2.1	-2.7	0.8	-1.7
Trunk predicted mass	1.7	9.6	16.7	-0.5	-0.8	3.6	-3.5	4.1	-2.9	4.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.6	1.2	-1.3	-0.3	2.2	-1.2	2.6	-1.5
Asthma (self-reported)	1.7	3.4	6.3	0.1	-1.9	1.4	-2.5	2.4	-1.3	2.1
Diastolic blood pressure, automated reading	1.7	5.1	9.5	-2.8	1.8	2.5	-0.2	2.0	-2.2	3.1
Relative age of first facial hair	1.6	3.2	6.8	-0.4	-1.1	2.6	-2.5	2.2	0.1	1.7
Trunk fat-free mass	1.6	9.5	16.6	-0.6	-0.8	3.6	-3.4	4.1	-2.9	4.0
Asthma	1.6	3.2	7.1	0.3	-1.6	1.3	-2.7	2.2	-1.4	2.0
Arm fat-free mass (right)	1.6	8.3	18.0	-1.0	-0.4	3.0	-2.9	3.3	-3.2	4.2
Number of children fathered	1.6	1.8	5.3	-0.1	0.5	1.6	-0.4	1.3	-1.6	2.3
Emphysema/chronic bronchitis	1.6	1.8	5.7	-1.0	-2.1	-0.2	-2.4	0.9	0.2	0.6
Heart disease (mother)	1.6	1.9	5.7	-0.6	0.9	-1.0	2.0	-1.2	2.4	-0.2
Arm predicted mass (right)	1.6	8.4	17.7	-0.8	-0.3	2.9	-3.0	3.4	-3.3	4.2
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	6.1	-0.7	-1.6	1.5	-1.9	2.5	-0.5	1.4
Supplements: Calcium	1.6	1.8	8.4	0.7	-2.9	-0.5	-1.4	0.3	0.6	-1.0
Arm predicted mass (left)	1.6	8.3	15.8	-1.1	-0.5	3.0	-3.1	3.5	-3.2	4.0
Neuroticism score	1.5	3.0	6.3	1.5	-0.5	-1.9	1.1	-2.4	1.2	-2.5
Tense / ‘highly strung’	1.5	2.5	4.3	-0.1	-1.3	-2.1	1.3	-2.0	1.9	-1.6
Exposure to tobacco smoke outside home	1.5	2.0	5.5	2.3	1.1	-0.8	0.9	-1.7	-0.0	-1.8
Mouth/teeth dental problems: Loose teeth	1.5	1.7	5.8	0.8	2.4	-0.0	-0.1	-0.3	2.3	-0.6
Arm fat-free mass (left)	1.5	7.9	15.5	-1.1	-0.1	2.7	-2.8	3.3	-3.4	3.9
Chronotype (morning person)	1.4	3.3	8.9	2.2	0.5	-1.3	3.0	-2.2	1.0	-1.3
Smoking status: Previous	1.4	2.1	9.1	3.0	0.1	-0.9	-0.3	-1.0	0.3	-2.0
Commuting to job workplace: Cycle	1.4	1.6	6.9	1.6	-0.1	0.5	0.5	-0.8	2.6	-1.0
Allergy or Eczema	1.3	3.5	8.5	-2.4	-0.8	1.5	-1.4	2.9	0.6	2.2
Respiratory disease	1.3	2.9	5.7	-0.8	-2.0	0.6	-2.4	2.0	-1.5	1.9
Past tobacco smoking	1.3	2.4	6.5	-2.5	1.3	1.3	1.0	0.7	-0.3	2.3
Weight	1.3	6.3	18.4	-1.0	-0.2	1.9	-1.7	2.5	-3.5	4.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.5	0.7	-0.4	-1.9	1.3	-1.5	1.3	-0.7
Medication: Aspirin	1.3	1.7	3.8	1.6	-0.5	-1.0	1.2	-2.0	0.5	-1.7
Medication: Aspirin	1.3	1.6	3.7	1.5	-0.8	-0.9	1.3	-1.9	0.1	-1.6
Average weekly champagne plus white wine intake	1.3	1.7	5.8	2.4	-0.2	-0.7	0.5	-1.4	0.4	-1.8
Guilty feelings	1.3	2.0	4.9	1.0	-0.5	-1.9	-0.1	-2.2	0.1	-2.1
Ever depressed for a whole week	1.3	1.7	5.8	1.6	0.6	-0.8	1.0	-0.9	2.4	-0.7
Mean Putamen Volume	1.2	1.3	3.2	1.0	-0.1	-1.6	0.6	-1.5	-0.1	-1.8
Lupus	1.2	1.8	5.7	-0.5	-0.9	0.7	-2.4	1.8	0.0	1.3
Heel T-Score	1.2	9.5	21.5	0.1	1.5	-4.6	4.1	-4.5	1.3	-1.8
Angina	1.2	1.6	3.0	0.4	0.4	-1.7	1.0	-1.7	1.5	-1.5
Serious illness, injury or assault to yourself	1.2	1.5	3.7	0.5	-1.0	-1.9	0.5	-1.5	-0.2	-1.7
Medication: Atenolol	1.2	1.5	2.7	-0.1	0.3	-1.3	1.2	-1.6	1.4	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	4.5	0.2	0.3	-1.6	1.7	-1.2	2.1	-1.0
Hearing difficulty/problems with background noise	1.2	1.9	5.9	1.7	-0.8	-0.1	-2.4	0.8	1.5	-1.0
Hair/balding pattern: Pattern 2	1.2	1.6	3.5	1.9	-1.3	1.0	-1.7	1.2	-0.9	-0.2
Length of working week for main job	1.2	1.4	4.2	1.3	0.1	-2.1	0.6	-1.4	-0.1	-1.0
Angina (self-reported)	1.2	1.6	2.8	0.6	0.7	-1.5	1.0	-1.7	1.6	-1.3
Medication: Allopurinol	1.2	1.6	5.1	-1.0	0.6	2.2	-0.9	1.4	-0.3	1.4
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	1.5	-0.3	-1.2	-0.7	-0.8	-1.4	-1.5
Blood Eosinophil Count	1.1	8.2	19.9	3.3	-0.9	-2.9	2.0	-1.5	4.5	-3.4
Impedance of leg (right)	1.1	5.3	9.3	0.3	0.1	-2.1	2.9	-3.0	2.4	-3.0
Impedance of leg (left)	1.1	5.4	10.3	0.6	0.4	-2.4	2.8	-3.2	2.1	-3.0
Alcohol usually taken with meals	1.1	1.8	11.4	3.4	0.1	0.1	-0.1	-0.3	0.5	-0.8
Forced vital capacity (FVC)	1.1	4.3	11.0	-1.2	-0.2	2.8	-2.0	3.3	-1.4	2.0
Medication: Simvastatin	1.1	1.6	3.5	0.3	0.6	-1.1	1.7	-1.4	1.1	-1.9
Exposure to tobacco smoke at home	1.1	1.2	3.6	-0.7	0.8	-1.0	1.9	-1.3	0.4	-0.9
Qualifications: nursing, teaching	1.1	1.7	3.6	-0.8	0.8	1.9	-1.0	1.9	-0.2	1.5
Medication for cholesterol	1.1	1.7	5.1	1.2	-2.3	0.7	-1.8	1.2	0.5	0.1
Schizophrenia vs Biploar Disorder	1.0	1.4	3.4	0.6	0.0	-1.3	1.1	-1.6	0.7	-1.8
Breast Cancer	1.0	2.5	12.2	-0.8	0.5	-0.1	1.9	-0.5	3.5	-0.7
Lung FVC	1.0	4.9	10.6	-3.3	0.7	2.1	-0.9	2.8	-1.3	2.9
Ever had hysterectomy (womb removed)	1.0	1.2	3.7	-1.9	-0.9	-0.2	1.8	-0.6	-0.2	0.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-0.6	-0.2	1.4	-1.6	1.3	-0.2	1.1
Medication: Levothyroxine sodium	1.0	1.7	9.8	0.4	0.3	-0.6	1.0	-0.8	3.1	-0.4
Diabetes (self-reported)	1.0	1.6	3.9	2.0	-0.5	-1.1	0.7	-1.4	0.4	-1.8
Worrier / anxious feelings	1.0	1.8	3.9	1.4	-1.2	-0.3	2.0	-1.3	1.4	-1.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.4	3.3	1.8	-1.2	0.4	-1.8	0.6	-1.0	-0.3
Medication: Paracetamol	1.0	1.6	5.0	0.7	-0.3	1.5	-2.2	0.8	-0.6	1.5
Worry too long after embarrassment	1.0	1.7	5.2	1.2	-0.9	-1.5	-0.8	-1.0	0.8	-2.3
Wheeze or whistling in the chest in last year	1.0	1.7	7.4	-0.9	-2.7	-0.1	-1.4	0.8	-0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.2	-1.6	0.5	0.6	-1.0	1.1	-0.2	1.8
Eye problems/disorders: Glaucoma	1.0	1.1	3.3	-1.7	-1.8	-0.1	-1.0	0.4	-0.7	0.2
Medication: Bendroflumethiazide	1.0	1.6	4.9	-1.6	2.2	-0.3	1.1	-0.9	1.2	-0.1
Average weekly beer plus cider intake	1.0	1.5	6.6	-2.6	-0.5	0.0	0.4	-0.3	-1.7	0.7
Cholesterol lowering medication	1.0	1.4	3.3	-0.3	1.8	-1.3	1.7	-1.2	0.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.8	2.0	-0.9	-1.0	-0.3	-1.4	0.1	-0.9
Hand grip strength (left)	0.9	2.5	4.9	0.1	-2.1	1.0	-2.0	2.2	-1.2	1.2
Vitamin and mineral supplements	0.9	1.2	3.2	-0.8	0.7	1.0	-0.6	1.2	-1.0	1.8
Medication: Co-codamol	0.9	1.1	2.0	-1.4	1.0	0.6	-1.3	0.4	-0.7	1.4
Severe depression (siblings)	0.9	1.1	3.7	1.9	-0.8	1.7	-0.1	0.4	0.3	0.3
Average weekly fortified wine intake	0.9	1.1	2.0	0.9	0.8	-1.1	1.4	-1.0	1.2	-0.8
Fed-up feelings	0.9	1.7	3.8	1.1	-0.0	-1.2	1.9	-2.0	0.6	-1.0
Relative age voice broke	0.9	1.4	4.3	0.8	-1.3	2.1	-0.9	1.5	0.3	0.6
Taking other prescription medications	0.9	1.3	3.6	1.6	-1.5	0.4	-1.9	0.2	0.4	0.9
Chronic bronchitis/emphysema (father)	0.9	1.1	3.4	-1.1	-1.0	0.7	-0.4	0.4	1.0	1.8
Mouth/teeth dental problems	0.9	1.4	3.6	-1.4	0.9	-0.9	1.9	-1.1	0.6	-1.0
Medication: Ramipril	0.9	1.1	2.1	-0.7	1.4	0.8	1.1	0.8	1.5	0.8
Alcohol intake versus 10 years previously	0.9	1.4	3.1	-1.5	-1.8	1.4	-0.7	0.9	1.1	0.2
Pulse rate	0.9	1.5	4.6	-0.1	-0.2	1.5	-1.1	0.7	-2.1	1.3
Number of full brothers	0.9	1.2	3.3	-0.8	-0.1	1.8	-1.2	1.6	-0.1	0.7
Leg fat mass (right)	0.9	3.5	11.2	-1.3	-0.1	0.4	-0.5	0.8	-3.3	3.2
Pulse rate, automated reading	0.9	2.9	8.6	-0.5	0.6	2.3	-1.0	0.9	-2.9	2.0
Number of full sisters	0.9	1.1	4.0	0.9	0.2	-0.2	-0.1	-0.7	2.0	-1.6
Leg pain on walking	0.9	1.1	2.6	0.7	1.5	-0.1	1.6	-0.8	0.1	-1.3
Mood swings	0.9	1.6	4.0	0.3	-0.1	-0.8	1.8	-2.0	0.5	-1.9
Commuting to job workplace: Walk	0.9	1.0	3.3	-0.2	1.6	-0.5	0.8	-0.3	1.8	-0.4
Number of self-reported non-cancer illnesses	0.9	1.6	2.9	0.1	-1.6	1.3	-1.2	0.9	1.7	1.3
Medication: Blood pressure	0.9	1.6	5.5	-0.6	2.3	-0.2	1.8	-1.3	0.7	-0.2
Impedance of whole body	0.9	4.5	7.3	0.5	-0.3	-2.0	2.6	-2.6	2.5	-2.7
Leg fat mass (left)	0.9	3.6	13.0	-1.1	-0.1	0.4	-0.6	0.7	-3.6	3.1
Bipolar Disorder (2018)	0.8	1.3	2.9	1.4	1.0	0.6	-1.7	1.4	-0.8	-0.1
Body Mass Index (BMI) (2010)	0.8	1.1	3.7	-0.3	0.5	0.5	-1.7	0.6	-1.9	0.3
Crohns Disease (2012)	0.8	1.4	2.9	1.1	0.1	-1.7	1.2	-1.6	-0.2	-1.2
Height	0.8	14.9	32.9	-1.8	-0.7	5.0	-4.2	5.7	-0.6	5.0
Lung FEV1/FVC ratio	0.8	3.9	9.6	-0.7	0.1	-2.5	3.0	-3.1	-0.9	-1.1
Neuroticism	0.8	1.8	4.2	1.7	-1.2	-1.1	0.8	-2.1	0.3	-1.5
Townsend deprivation index at recruitment	0.8	1.2	3.0	0.5	1.5	-1.7	-0.2	-1.3	0.2	-1.0
High blood pressure (mother)	0.8	1.1	3.8	-1.2	-1.9	-0.2	0.5	-0.3	1.4	0.6
Body mass index (BMI)	0.8	3.2	10.2	-1.0	0.1	0.5	-0.7	0.8	-3.2	3.1
Illnesses of siblings	0.8	1.1	2.4	1.6	1.0	0.3	-1.3	-0.0	-1.5	0.2
Impedance of arm (right)	0.8	3.9	7.0	0.7	-0.6	-1.4	2.6	-2.1	2.5	-2.6
Time employed in main current job	0.8	0.9	2.0	1.0	1.2	-0.9	-0.2	-1.1	-0.4	-1.4
Arm fat mass (right)	0.8	3.5	12.2	-0.8	-0.1	0.8	-0.7	1.1	-3.0	3.5
Medication: Amlodipine	0.8	1.1	4.1	0.7	0.9	-0.1	1.2	-1.0	2.0	-0.0
High blood pressure (siblings)	0.8	1.2	4.8	-2.2	-0.7	0.1	0.5	0.8	1.1	0.9
Forced vital capacity (FVC), Best measure	0.8	2.9	6.9	-0.8	0.5	2.4	-1.2	2.6	-1.1	2.0
Whole body fat mass	0.8	3.2	11.4	-1.1	-0.2	0.6	-0.3	0.8	-3.0	3.4
Age at last live birth	0.8	1.2	6.8	-0.1	2.6	0.8	-0.1	0.8	0.5	-0.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	5.5	0.5	2.3	0.3	-0.9	0.0	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.2	-1.3	2.5	0.8	1.6	-0.2	-0.0	0.8
Arm fat mass (left)	0.8	3.5	12.1	-0.5	-0.4	0.8	-0.8	1.1	-3.1	3.5
Ever taken oral contraceptive pill	0.8	0.9	1.6	0.1	1.3	-1.0	0.8	-0.7	1.1	-1.1
Illnesses of father: High blood pressure	0.8	1.0	3.3	1.2	-1.8	1.1	0.1	0.7	-1.0	0.1
Alcohol drinker status: Never	0.8	0.9	4.0	-2.0	-0.2	0.2	1.0	-0.2	0.8	0.8
Age started oral contraceptive pill	0.8	1.0	3.1	0.1	0.4	-0.8	1.6	-0.6	1.8	0.4
Alzheimer’s Disease (in father)	0.7	0.8	2.6	-1.2	1.0	-0.5	-1.6	0.2	-0.1	-0.4
Triglycerides	0.7	1.2	3.7	-1.0	1.9	0.5	-0.7	1.1	-0.9	0.7
Trunk fat mass	0.7	3.0	11.8	-0.9	-0.2	0.4	-0.2	0.7	-2.8	3.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	8.0	0.5	1.1	-0.2	0.2	-0.3	2.8	0.1
Age at first live birth	0.7	1.2	5.2	0.3	1.1	1.0	0.5	0.5	2.3	-0.6
Neck or shoulder pain in last month	0.7	1.0	1.8	1.3	-0.2	-1.3	-1.3	-0.3	0.2	-1.2
Medication: Blood pressure	0.7	1.3	4.3	-0.4	-0.7	-0.0	1.2	-0.9	2.1	-1.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.8	-0.9	1.1	0.2	-1.3	0.9	-0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.4	-1.4	-0.3	1.9	0.2	1.7	-0.6	1.3
Long-standing illness, disability or infirmity	0.7	1.0	2.6	1.5	-1.1	0.8	-0.3	-0.3	1.6	-0.3
Diabetes diagnosed by doctor	0.7	1.1	3.2	0.9	-0.7	-0.9	0.9	-1.2	0.6	-1.8
Medication: Gliclazide	0.7	0.8	3.3	1.2	-1.8	0.7	-0.1	0.7	0.1	-0.1
Risk taking	0.7	1.0	3.0	-1.0	1.7	-0.9	0.8	-0.6	0.5	-0.8
Pack years of smoking	0.7	1.0	3.3	-0.7	-0.7	-1.8	0.7	-1.4	-0.5	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	2.6	0.4	0.5	-0.9	-1.6	0.1	-1.2	-0.6
Prostate Cancer	0.6	0.8	2.3	-0.7	1.5	-0.7	-0.0	-0.2	-1.4	0.3
HDL Cholesterol	0.6	1.1	3.2	-1.1	-0.8	1.8	0.2	0.7	-0.6	1.1
Blood Red Count	0.6	5.7	13.9	0.4	-0.2	-3.4	2.7	-3.7	0.6	-2.5
Smoking Status	0.6	1.6	3.2	1.3	-1.4	-1.8	-0.5	-0.9	-0.3	-1.7
Hypothyroidism (self reported)	0.6	1.3	7.8	0.9	0.5	-0.0	0.3	0.3	2.8	-0.3
Hearing difficulty/problems: Yes	0.6	0.8	2.1	1.5	-0.3	0.9	-1.4	0.9	-0.3	0.3
Pack years adult smoking proportion	0.6	0.9	2.3	-1.0	-0.9	-1.5	0.4	-1.1	-0.9	-0.1
Hand grip strength (right)	0.6	1.6	4.8	-0.1	-0.9	1.0	-1.6	2.2	-0.8	1.2
Current tobacco smoking	0.6	0.9	4.4	-2.1	-0.3	-1.0	-0.7	0.2	-0.1	0.6
Age when periods started (menarche)	0.6	1.5	3.3	0.1	-1.0	1.0	-1.1	1.8	1.0	1.6
Stomach or abdominal pain in last month	0.6	0.8	4.3	0.6	-2.1	-0.5	-0.5	0.3	0.4	-0.1
Had menopause	0.6	0.8	1.8	1.3	-1.4	0.4	-0.7	0.0	-0.9	-0.9
Arm fat percentage (right)	0.6	2.2	7.5	-0.7	-0.3	-0.0	0.2	0.1	-2.7	2.7
Depression (self-reported)	0.6	0.7	3.4	0.6	0.9	-0.3	0.6	-0.4	1.8	-0.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	-0.1	-0.1	1.4	-0.7	0.8	-1.3	0.6
Impedance of arm (left)	0.6	2.8	5.9	1.2	-0.6	-1.2	1.9	-1.7	2.4	-2.0
Loud music exposure frequency	0.6	0.7	1.4	-0.2	0.2	-0.9	1.2	-1.0	-0.8	-0.8
Blood clot in the leg (DVT)	0.6	0.7	2.6	1.6	-0.7	-0.4	-0.6	-1.0	-0.0	-0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.7	0.7	0.4	-0.0	-0.9	0.6	-1.9	1.1
Glaucoma (self-reported)	0.6	0.7	1.6	-1.2	-1.3	-0.9	-0.9	0.3	-0.2	0.0
Pulse wave peak to peak time	0.6	0.7	2.1	0.0	0.2	-1.4	0.7	-0.7	1.2	-0.6
Chest pain or discomfort	0.6	0.9	4.9	0.1	0.3	-0.3	1.0	-0.6	2.2	-0.0
Supplements: Vitamin C	0.6	0.7	1.7	-0.1	-1.0	-1.0	-1.1	-0.4	-0.2	-1.3
Arm fat percentage (left)	0.6	2.3	7.8	-0.3	-0.4	-0.2	0.0	0.0	-2.8	2.8
Average weekly red wine intake	0.6	0.9	1.4	1.2	0.5	0.6	-1.1	1.2	-1.1	0.5
Back pain experienced in last month	0.6	0.8	2.9	0.8	-1.7	-1.4	-0.3	-0.3	-0.4	-0.4
Osteoarthritis (self-reported)	0.6	0.8	1.3	1.0	0.5	-0.7	1.0	-1.1	-0.5	-1.0
Hearing aid user	0.6	0.7	1.7	-0.2	1.3	0.9	0.3	1.2	0.0	0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	-0.5	-0.1	1.6	-0.5	0.6	-0.0	1.4
Fractured/broken bones in last 5 years	0.6	0.8	2.5	0.1	-1.2	1.6	-0.9	1.0	0.1	0.0
Bipolar Disorder or Schizophrenia	0.5	1.3	3.9	0.9	1.9	-0.3	-2.0	0.7	-0.5	-0.5
Ovarian Cancer	0.5	0.6	2.1	1.1	0.5	0.3	-0.9	-0.0	1.5	-0.1
LDL Cholesterol	0.5	0.8	2.0	-1.0	1.0	-1.4	0.9	-0.8	-0.2	0.2
BMI	0.5	2.9	11.8	-0.9	0.5	-0.2	-0.9	0.7	-3.4	2.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.2	0.7	-0.8	-1.3	1.0	-0.9	0.6	-1.5
Number of treatments/medications taken	0.5	0.9	2.5	0.9	-0.9	-0.4	-0.3	-1.0	1.6	-0.8
Sensitivity / hurt feelings	0.5	0.8	2.3	1.4	-1.5	-0.1	0.1	-0.6	0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	0.8	-1.3	0.2	-0.8	0.7	0.9	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.7	-0.5	-0.8	-0.0	1.6	-0.1	0.3	-1.0
Diabetes (father)	0.5	0.6	2.6	-1.6	-0.6	0.1	1.2	0.2	-0.2	0.1
Trunk fat percentage	0.5	1.9	6.1	-0.7	0.2	-0.9	0.8	-0.6	-2.3	2.5
Supplements: Glucosamine	0.5	0.6	2.6	1.6	0.0	0.8	-0.6	0.7	-0.6	0.0
Number of live births	0.5	0.7	1.9	1.2	0.7	0.1	0.4	-0.8	-1.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	0.3	-0.2	1.1	0.3	0.7	1.4	0.5
Standing height	0.5	4.5	11.3	0.1	-0.8	3.1	-1.9	3.4	-0.5	2.5
Breastfed as a baby	0.5	0.6	1.3	0.1	0.8	-0.7	0.8	-0.4	0.9	-1.1
Hair/balding pattern: Pattern 4	0.5	1.1	3.3	-0.8	-1.4	-0.8	1.8	-0.7	-0.5	-0.6
Body fat percentage	0.5	2.0	6.0	-0.8	0.1	-0.7	0.8	-0.6	-2.4	2.4
Leg fat percentage (right)	0.5	1.8	5.7	-0.8	0.2	-1.0	1.1	-1.1	-2.4	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	1.2	-1.0	-0.5	0.6	-0.9	0.3	-0.4
Health satisfaction	0.5	0.7	1.6	1.3	-1.0	-0.4	0.7	-0.5	0.4	-1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.9	0.8	-0.6	0.4	-1.4	0.7	0.2	0.5
Alcohol intake frequency.	0.5	1.3	6.8	-2.6	0.3	0.6	-0.4	0.3	-0.2	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	0.2	0.6	-1.0	0.5	-1.4	-0.7	-0.3
Smoking status: Current	0.5	0.7	3.1	-1.8	-0.7	-0.8	-0.6	0.2	-0.3	0.6
Wears glasses or contact lenses	0.5	0.6	1.5	-0.6	0.9	0.2	1.2	0.0	1.2	0.2
High cholesterol (Self-reported)	0.5	0.9	2.0	-0.7	1.4	-0.7	1.4	-0.5	0.6	-0.6
Leg fat percentage (left)	0.5	1.8	6.4	-0.4	0.4	-1.2	0.9	-1.2	-2.5	1.6
Pain experienced in last month	0.5	0.9	1.8	-0.8	0.6	-0.7	1.3	-1.0	1.2	-0.8
Age at First Birth	0.4	0.6	2.7	0.0	-0.3	-0.5	0.2	-0.5	1.6	-0.9
Neuroticism (2016)	0.4	0.5	1.4	0.9	-0.3	1.0	0.7	-0.4	1.2	-0.1
Schizophrenia (2014)	0.4	0.8	2.7	0.1	1.1	-0.9	-1.6	0.1	-0.5	-0.6
Systolic Blood Pressure	0.4	2.0	5.9	-1.1	2.4	0.4	2.2	-1.1	0.9	-0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.2	-0.0	-0.4	-0.5	1.5	-0.4	0.1	0.7
Multivitamins +/- minerals	0.4	0.5	2.0	0.5	-1.4	-0.1	0.7	-0.6	0.2	-0.7
Hip circumference	0.4	1.8	8.5	-0.8	-0.8	0.5	0.2	0.7	-1.5	2.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	-0.8	-0.0	1.6	-0.2	1.4	-1.6	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	1.0	-0.9	0.3	-0.9	0.0	-0.5	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.9	0.1	-0.5	0.2	1.2	-0.5	1.4	-0.8
Medication: Lansoprazole	0.4	0.5	1.5	0.3	-0.2	-0.8	0.5	-1.2	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.4	-0.6	0.3	1.5	0.1	1.2	-1.4	1.4
Migraine (self-reported)	0.4	0.4	1.0	-0.9	-0.7	0.6	-0.3	0.3	0.6	1.0
Medication: Ibuprofen	0.4	0.5	2.1	1.4	-0.1	0.8	-0.7	0.2	0.1	-0.2
Medication: Omeprazole	0.4	0.4	1.2	-1.1	-0.8	-0.3	-0.4	0.3	-0.7	0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.2	-1.2	0.7	-0.5	0.7	-0.7	-0.1
Eye problems/disorders: Cataract	0.4	0.4	1.0	0.6	0.0	0.7	-1.0	0.9	-0.2	0.6
Alcohol drinker status: Previous	0.4	0.5	1.4	-1.2	-0.2	0.9	-0.2	0.2	0.6	0.9
Schizophrenia (2018)	0.3	0.7	2.7	-0.0	1.6	-0.8	-1.1	-0.3	0.2	-0.6
Fasting Glucose	0.3	0.3	0.8	0.7	-0.7	0.0	-0.9	0.4	0.5	-0.2
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.3	0.8	-0.4	-0.6	-0.8	-0.9	-0.7
Rheumatoid Arthritis	0.3	0.4	1.8	0.5	-0.0	-0.4	0.5	-0.3	1.4	0.4
Systolic blood pressure, automated reading	0.3	1.0	3.4	-1.3	1.9	-0.4	1.0	-0.6	-0.4	0.2
Medication: Metformin	0.3	0.5	2.3	0.8	-1.5	0.2	0.1	0.0	0.6	-0.1
Pain all over the body in last month	0.3	0.4	1.0	0.5	1.0	-0.3	0.5	-1.0	0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.5	-1.2	-0.8	0.4	-0.0	0.2	0.2	0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.6	-0.1	0.5	-0.8	-0.2	1.2	0.2
Happiness	0.3	0.3	0.8	0.7	-0.3	0.6	-0.5	0.2	0.4	-0.9
Noisy workplace	0.3	0.4	1.0	0.4	0.4	-0.5	1.0	-0.6	0.8	-0.5
Illnesses of mother	0.3	0.4	1.3	-0.6	1.1	0.4	-0.4	0.8	-0.5	0.2
Peak expiratory flow (PEF)	0.3	0.7	2.2	0.4	0.3	-0.6	1.5	-1.1	-0.6	-0.4
Pulse wave reflection index	0.3	0.4	1.1	-0.4	0.1	0.4	1.0	-0.6	0.9	-0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.3	0.8	0.6	0.1	0.4	-0.4	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-1.1	1.0	-0.2	0.7	0.5	0.5	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.5	-0.4	-0.6	0.9	-0.7	-0.2	-0.7
Comparative height size at age 10	0.3	1.8	4.7	0.8	0.1	2.2	-0.4	1.5	-1.0	2.0
Overall health rating	0.3	0.6	1.8	0.7	-1.1	-1.3	-0.6	-0.5	0.1	-0.4
Family relationship satisfaction	0.3	0.3	1.1	0.2	0.6	0.0	-0.9	0.0	0.2	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	-0.2	-0.8	-0.2	-0.0	0.2	1.1	0.6
Knee pain experienced in last month	0.3	0.5	1.9	-0.5	1.4	0.8	0.4	0.5	0.0	0.8
Ever had bowel cancer screening	0.3	0.3	0.5	0.3	-0.7	0.7	-0.7	0.4	-0.1	0.7
Breast cancer (self-reported)	0.3	0.4	1.0	0.6	-0.5	1.0	0.0	-0.2	-0.9	0.3
Osteoporosis (self-reported)	0.3	0.4	2.4	-0.0	-0.1	-0.2	0.5	0.1	1.6	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	1.2	-0.2	-0.5	-0.6	-0.2	0.9	0.0
Irritability	0.3	0.6	2.1	0.3	-1.0	0.4	0.3	-0.6	-0.1	-1.5
Myopia	0.3	0.4	1.5	-0.6	0.8	-0.2	0.2	0.3	1.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	-0.4	0.1	-0.3	-0.5	0.2	-1.2	0.6
HbA1C	0.2	0.2	0.6	-0.8	0.4	-0.5	-0.5	0.3	-0.4	0.2
Cardiovascular Disease	0.2	0.6	3.3	-0.5	0.4	0.1	0.6	-0.2	-1.8	-0.6
Average weekly spirits intake	0.2	0.2	0.7	-0.8	0.6	0.2	0.4	0.1	-0.4	0.4
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.3	-0.8	-0.2	0.8	-0.1	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.2	-0.7	0.3	0.2	0.2	1.0	0.5
Sitting height	0.2	1.7	6.9	-0.1	0.4	1.1	-0.1	1.5	-1.2	2.6
Had other major operations	0.2	0.2	0.4	0.3	-0.7	0.1	-0.4	0.7	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	1.1	-0.3	-0.3	-0.3	0.1	0.9	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.5	0.4	-0.5	-0.1	-0.5	-0.6	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.7	-0.7	-0.0	-0.3	-0.1	0.2	0.8
Comparative body size at age 10	0.2	0.7	2.6	0.6	0.2	-1.0	-0.7	-0.0	-1.6	-0.3
Shortness of breath walking on level ground	0.2	0.2	0.5	0.4	-0.7	0.4	-0.6	0.4	-0.0	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.4	-0.8	-0.3	0.7	-0.2	-0.1	-0.2
Hypertension (Self-reported)	0.2	0.5	1.6	-0.9	0.5	1.3	-0.4	0.5	0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.1	0.2	0.6	-0.6	0.2	0.7	-0.2
Friendships satisfaction	0.2	0.3	0.6	-0.8	0.0	0.8	-0.6	0.6	0.2	-0.3
Mineral and other dietary supplements	0.2	0.2	1.1	-1.0	0.4	-0.5	0.1	0.4	0.0	0.2
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.6	-0.6	-0.7	0.1	-0.5	0.5	-0.3
Medication: Atorvastatin	0.2	0.2	0.7	0.2	0.7	-0.4	0.8	-0.4	0.2	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.7	-0.3	0.4	-0.7	0.7	-0.6	0.0
Tanning	0.1	0.8	2.4	0.8	-0.2	-1.6	0.5	-1.2	-0.2	-0.9
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.6	-0.3	-0.8	0.2	0.1	0.3	-0.2
High blood pressure	0.1	0.2	0.6	-0.6	0.2	0.8	-0.5	0.3	0.4	0.2
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.6	-0.3	-0.0	0.1	0.0	-0.4	-0.6
Falls in the last year	0.1	0.1	0.2	0.5	0.3	0.1	0.1	0.0	0.3	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.2	-0.1	0.2	0.3	-0.1	-0.1	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.4	0.4	0.5	-0.4	-0.7	0.1	0.4	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	0.5	-0.3	0.2	-0.1	0.7	-0.9	0.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.0	2.6	1.0	-1.5	1.6	-0.9	0.7	-0.1	0.2

Hub : Genes

FCHO1

Models

Trait associations