Hub : Genes

FCHO1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0320	1.4e-02	0.027	0.033	0.030	0.040	0.043	2.6e-04	5.9e-05	1.3e-04	9.7e-06	4.9e-06
2	GTEx	Brain Cerebellum	0.3950	0.1180	9.4e-03	0.183	NA	0.114	NA	0.159	4.4e-06	NA	3.0e-04	NA	2.0e-05
3	GTEx	Nerve Tibial	0.2091	0.0561	3.8e-04	0.044	NA	0.065	NA	0.053	4.2e-04	NA	2.3e-05	NA	1.3e-04
4	GTEx	Whole Blood	0.1510	0.0370	3.1e-05	0.114	NA	0.085	NA	0.091	1.2e-10	NA	3.1e-08	NA	9.6e-09
5	METSIM	Adipose	0.0459	0.0185	6.6e-03	0.030	0.012	0.029	0.024	0.038	2.0e-05	4.7e-03	2.7e-05	1.2e-04	2.1e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.1133	0.0330	1.5e-04	0.040	0.035	0.064	0.048	0.027	5.8e-06	2.0e-05	1.3e-08	7.7e-07	1.9e-04
7	YFS	Blood	0.0951	0.0178	1.7e-16	0.069	0.053	0.067	0.068	0.067	1.5e-21	6.7e-17	5.5e-21	2.0e-21	4.8e-21

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.3	2.9	1.4	1.0	0.6	-1.7	1.4	-0.8	-0.1
Bipolar Disorder or Schizophrenia	0.5	1.3	3.9	0.9	1.9	-0.3	-2.0	0.7	-0.5	-0.5
Depressed Affect (Nagel 2018)	1.9	4.0	10.2	0.4	-0.5	-2.0	2.6	-3.2	1.5	-2.0
Depression (Nagel 2018)	2.5	3.8	7.2	1.3	-0.1	-2.4	2.2	-2.4	1.2	-2.7
Intelligence (Savage-Jansen 2018)	3.0	9.1	19.8	-2.8	-1.5	4.5	-3.4	3.9	-0.9	2.5
Neuroticism (Nagel 2018)	1.8	4.2	8.1	1.4	-1.9	-2.0	1.6	-2.8	1.4	-2.7
Schizophrenia (2018)	0.3	0.7	2.7	-0.0	1.6	-0.8	-1.1	-0.3	0.2	-0.6
Schizophrenia vs Biploar Disorder	1.0	1.4	3.4	0.6	0.0	-1.3	1.1	-1.6	0.7	-1.8
Worry (Nagel 2018)	2.0	4.3	5.6	2.3	-1.9	-2.0	1.8	-2.4	2.0	-2.1
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	1.5	-0.3	-1.2	-0.7	-0.8	-1.4	-1.5
Alzheimer’s Disease (in father)	0.7	0.8	2.6	-1.2	1.0	-0.5	-1.6	0.2	-0.1	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.8	2.6	0.4	0.5	-0.9	-1.6	0.1	-1.2	-0.6
Crohns Disease (2017)	2.2	4.8	8.9	2.1	1.0	-3.0	1.8	-2.6	1.8	-2.4
Irritable Bowel Disease (IBD)	3.3	7.9	14.2	2.9	0.7	-3.8	2.1	-3.6	1.4	-3.6
Ulcerative Colitis (UC)	2.6	4.9	9.5	2.1	0.1	-3.0	1.6	-2.9	0.7	-3.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.9	3.6	9.7	0.1	0.6	-0.9	2.9	-1.0	2.2	-3.1
Verbal and Numeric Reasoning (VNR)	3.9	9.4	18.7	-2.4	-0.9	4.3	-4.2	4.1	-1.3	2.1
Breast Cancer	1.0	2.5	12.2	-0.8	0.5	-0.1	1.9	-0.5	3.5	-0.7
Ovarian Cancer	0.5	0.6	2.1	1.1	0.5	0.3	-0.9	-0.0	1.5	-0.1
Prostate Cancer	0.6	0.8	2.3	-0.7	1.5	-0.7	-0.0	-0.2	-1.4	0.3
Age at First Birth	0.4	0.6	2.7	0.0	-0.3	-0.5	0.2	-0.5	1.6	-0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.7	-0.3	0.5	0.5	-1.7	0.6	-1.9	0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.8	1.4	2.9	1.1	0.1	-1.7	1.2	-1.6	-0.2	-1.2
Mean Putamen Volume	1.2	1.3	3.2	1.0	-0.1	-1.6	0.6	-1.5	-0.1	-1.8
Fasting Glucose	0.3	0.3	0.8	0.7	-0.7	0.0	-0.9	0.4	0.5	-0.2
HbA1C	0.2	0.2	0.6	-0.8	0.4	-0.5	-0.5	0.3	-0.4	0.2
HDL Cholesterol	0.6	1.1	3.2	-1.1	-0.8	1.8	0.2	0.7	-0.6	1.1
LDL Cholesterol	0.5	0.8	2.0	-1.0	1.0	-1.4	0.9	-0.8	-0.2	0.2
Lupus	1.2	1.8	5.7	-0.5	-0.9	0.7	-2.4	1.8	0.0	1.3
Neuroticism (2016)	0.4	0.5	1.4	0.9	-0.3	1.0	0.7	-0.4	1.2	-0.1
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.3	0.8	-0.4	-0.6	-0.8	-0.9	-0.7
Rheumatoid Arthritis	0.3	0.4	1.8	0.5	-0.0	-0.4	0.5	-0.3	1.4	0.4
Schizophrenia (2014)	0.4	0.8	2.7	0.1	1.1	-0.9	-1.6	0.1	-0.5	-0.6
Triglycerides	0.7	1.2	3.7	-1.0	1.9	0.5	-0.7	1.1	-0.9	0.7
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	2.9	4.2	8.5	2.3	0.4	-2.8	0.9	-2.6	0.3	-2.9
Blood Eosinophil Count	1.1	8.2	19.9	3.3	-0.9	-2.9	2.0	-1.5	4.5	-3.4
Blood Platelet Count	2.6	29.9	53.0	2.9	2.0	-7.3	6.5	-6.5	4.7	-6.1
Blood Red Count	0.6	5.7	13.9	0.4	-0.2	-3.4	2.7	-3.7	0.6	-2.5
Blood White Count	2.0	14.6	26.6	2.1	1.1	-4.7	5.0	-5.2	3.1	-3.6
Heel T-Score	1.2	9.5	21.5	0.1	1.5	-4.6	4.1	-4.5	1.3	-1.8
BMI	0.5	2.9	11.8	-0.9	0.5	-0.2	-0.9	0.7	-3.4	2.4
Height	0.8	14.9	32.9	-1.8	-0.7	5.0	-4.2	5.7	-0.6	5.0
Waist Hip Ratio (WHR)	3.3	14.8	23.5	-1.1	-0.8	4.4	-4.7	4.4	-4.8	4.2
Systolic Blood Pressure	0.4	2.0	5.9	-1.1	2.4	0.4	2.2	-1.1	0.9	-0.5
Smoking Status	0.6	1.6	3.2	1.3	-1.4	-1.8	-0.5	-0.9	-0.3	-1.7
Allergy or Eczema	1.3	3.5	8.5	-2.4	-0.8	1.5	-1.4	2.9	0.6	2.2
Cardiovascular Disease	0.2	0.6	3.3	-0.5	0.4	0.1	0.6	-0.2	-1.8	-0.6
Hypothyroidism (self reported)	0.6	1.3	7.8	0.9	0.5	-0.0	0.3	0.3	2.8	-0.3
Respiratory disease	1.3	2.9	5.7	-0.8	-2.0	0.6	-2.4	2.0	-1.5	1.9
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.2	0.7	-0.8	-1.3	1.0	-0.9	0.6	-1.5
Lung FEV1/FVC ratio	0.8	3.9	9.6	-0.7	0.1	-2.5	3.0	-3.1	-0.9	-1.1
Lung FVC	1.0	4.9	10.6	-3.3	0.7	2.1	-0.9	2.8	-1.3	2.9
Neuroticism	0.8	1.8	4.2	1.7	-1.2	-1.1	0.8	-2.1	0.3	-1.5
Chronotype (morning person)	1.4	3.3	8.9	2.2	0.5	-1.3	3.0	-2.2	1.0	-1.3
Hair Pigment	0.0	1.0	2.6	1.0	-1.5	1.6	-0.9	0.7	-0.1	0.2
Tanning	0.1	0.8	2.4	0.8	-0.2	-1.6	0.5	-1.2	-0.2	-0.9
Hand grip strength (left)	0.9	2.5	4.9	0.1	-2.1	1.0	-2.0	2.2	-1.2	1.2
Number of treatments/medications taken	0.5	0.9	2.5	0.9	-0.9	-0.4	-0.3	-1.0	1.6	-0.8
Average weekly spirits intake	0.2	0.2	0.7	-0.8	0.6	0.2	0.4	0.1	-0.4	0.4
Sensitivity / hurt feelings	0.5	0.8	2.3	1.4	-1.5	-0.1	0.1	-0.6	0.2	-0.8
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.3	1.8	-0.2	-1.3	2.1	-1.8	1.4	-2.0
Hearing difficulty/problems: Yes	0.6	0.8	2.1	1.5	-0.3	0.9	-1.4	0.9	-0.3	0.3
Relative age of first facial hair	1.6	3.2	6.8	-0.4	-1.1	2.6	-2.5	2.2	0.1	1.7
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	0.8	-1.3	0.2	-0.8	0.7	0.9	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.7	-0.5	-0.8	-0.0	1.6	-0.1	0.3	-1.0
Ever had hysterectomy (womb removed)	1.0	1.2	3.7	-1.9	-0.9	-0.2	1.8	-0.6	-0.2	0.3
Systolic blood pressure, automated reading	0.3	1.0	3.4	-1.3	1.9	-0.4	1.0	-0.6	-0.4	0.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-0.6	-0.2	1.4	-1.6	1.3	-0.2	1.1
Angina	1.2	1.6	3.0	0.4	0.4	-1.7	1.0	-1.7	1.5	-1.5
Medication for hormone replacement therapy	0.2	0.3	0.7	-0.3	-0.8	-0.2	0.8	-0.1	-0.1	-0.6
Vitamin and mineral supplements	0.9	1.2	3.2	-0.8	0.7	1.0	-0.6	1.2	-1.0	1.8
Supplements: Zinc	2.7	2.9	7.4	1.3	-1.9	-1.9	0.2	-1.5	1.4	-2.7
Medication: Co-codamol	0.9	1.1	2.0	-1.4	1.0	0.6	-1.3	0.4	-0.7	1.4
Medication: Metformin	0.3	0.5	2.3	0.8	-1.5	0.2	0.1	0.0	0.6	-0.1
Diabetes (father)	0.5	0.6	2.6	-1.6	-0.6	0.1	1.2	0.2	-0.2	0.1
Diabetes (mother)	2.9	3.7	7.2	-2.0	-2.7	2.2	-1.5	1.6	-1.8	1.5
Severe depression (siblings)	0.9	1.1	3.7	1.9	-0.8	1.7	-0.1	0.4	0.3	0.3
Pack years adult smoking proportion	0.6	0.9	2.3	-1.0	-0.9	-1.5	0.4	-1.1	-0.9	-0.1
Impedance of leg (right)	1.1	5.3	9.3	0.3	0.1	-2.1	2.9	-3.0	2.4	-3.0
Leg fat-free mass (left)	1.9	10.1	20.2	-1.3	-1.0	3.1	-3.0	4.0	-3.5	4.5
Trunk fat percentage	0.5	1.9	6.1	-0.7	0.2	-0.9	0.8	-0.6	-2.3	2.5
Hand grip strength (right)	0.6	1.6	4.8	-0.1	-0.9	1.0	-1.6	2.2	-0.8	1.2
Townsend deprivation index at recruitment	0.8	1.2	3.0	0.5	1.5	-1.7	-0.2	-1.3	0.2	-1.0
Current tobacco smoking	0.6	0.9	4.4	-2.1	-0.3	-1.0	-0.7	0.2	-0.1	0.6
Average weekly fortified wine intake	0.9	1.1	2.0	0.9	0.8	-1.1	1.4	-1.0	1.2	-0.8
Maternal smoking around birth	1.8	2.7	5.7	-2.4	-1.1	1.1	-1.7	1.6	-2.0	1.1
Fed-up feelings	0.9	1.7	3.8	1.1	-0.0	-1.2	1.9	-2.0	0.6	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	6.4	1.1	1.2	-2.1	1.4	-2.2	0.9	-2.5
Relative age voice broke	0.9	1.4	4.3	0.8	-1.3	2.1	-0.9	1.5	0.3	0.6
Taking other prescription medications	0.9	1.3	3.6	1.6	-1.5	0.4	-1.9	0.2	0.4	0.9
Age when periods started (menarche)	0.6	1.5	3.3	0.1	-1.0	1.0	-1.1	1.8	1.0	1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.2	-0.0	-0.4	-0.5	1.5	-0.4	0.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	10.4	-0.2	1.1	-3.2	2.1	-2.7	0.8	-1.7
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	5.2	0.6	-0.3	-2.3	1.5	-2.2	1.8	-1.9
Qualifications: CSEs or equivalent	0.1	0.2	0.7	-0.6	-0.3	-0.8	0.2	0.1	0.3	-0.2
Serious illness, injury or assault to yourself	1.2	1.5	3.7	0.5	-1.0	-1.9	0.5	-1.5	-0.2	-1.7
High blood pressure	0.1	0.2	0.6	-0.6	0.2	0.8	-0.5	0.3	0.4	0.2
Hayfever, allergic rhinitis or eczema	1.8	4.0	9.5	-1.7	-0.6	2.4	-2.0	3.1	0.5	2.4
Multivitamins +/- minerals	0.4	0.5	2.0	0.5	-1.4	-0.1	0.7	-0.6	0.2	-0.7
Stomach or abdominal pain in last month	0.6	0.8	4.3	0.6	-2.1	-0.5	-0.5	0.3	0.4	-0.1
Supplements: Glucosamine	0.5	0.6	2.6	1.6	0.0	0.8	-0.6	0.7	-0.6	0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.0	0.2	-0.7	0.3	0.2	0.2	1.0	0.5
Medication: Atenolol	1.2	1.5	2.7	-0.1	0.3	-1.3	1.2	-1.6	1.4	-1.5
Medication: Levothyroxine sodium	1.0	1.7	9.8	0.4	0.3	-0.6	1.0	-0.8	3.1	-0.4
Sitting height	0.2	1.7	6.9	-0.1	0.4	1.1	-0.1	1.5	-1.2	2.6
Chronic bronchitis/emphysema (father)	0.9	1.1	3.4	-1.1	-1.0	0.7	-0.4	0.4	1.0	1.8
High blood pressure (mother)	0.8	1.1	3.8	-1.2	-1.9	-0.2	0.5	-0.3	1.4	0.6
Body mass index (BMI)	0.8	3.2	10.2	-1.0	0.1	0.5	-0.7	0.8	-3.2	3.1
Impedance of leg (left)	1.1	5.4	10.3	0.6	0.4	-2.4	2.8	-3.2	2.1	-3.0
Leg predicted mass (left)	1.9	10.2	20.6	-1.2	-1.0	3.2	-3.1	4.0	-3.5	4.5
Trunk fat mass	0.7	3.0	11.8	-0.9	-0.2	0.4	-0.2	0.7	-2.8	3.4
Waist circumference	2.0	7.5	18.1	-1.0	-1.0	2.3	-2.3	2.6	-3.9	4.2
Number of incorrect matches in round	3.9	6.5	12.9	1.8	-0.8	-2.3	3.0	-2.7	2.6	-3.6
Past tobacco smoking	1.3	2.4	6.5	-2.5	1.3	1.3	1.0	0.7	-0.3	2.3
Alcohol usually taken with meals	1.1	1.8	11.4	3.4	0.1	0.1	-0.1	-0.3	0.5	-0.8
Nervous feelings	2.1	4.0	6.6	1.8	-1.2	-1.9	1.9	-2.6	1.7	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	4.5	0.2	0.3	-1.6	1.7	-1.2	2.1	-1.0
Hearing difficulty/problems with background noise	1.2	1.9	5.9	1.7	-0.8	-0.1	-2.4	0.8	1.5	-1.0
Hair/balding pattern: Pattern 2	1.2	1.6	3.5	1.9	-1.3	1.0	-1.7	1.2	-0.9	-0.2
Had menopause	0.6	0.8	1.8	1.3	-1.4	0.4	-0.7	0.0	-0.9	-0.9
Had other major operations	0.2	0.2	0.4	0.3	-0.7	0.1	-0.4	0.7	-0.6	-0.4
Forced vital capacity (FVC)	1.1	4.3	11.0	-1.2	-0.2	2.8	-2.0	3.3	-1.4	2.0
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	17.0	0.1	0.7	-4.1	2.9	-3.2	1.2	-2.0
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	4.6	1.6	1.2	-0.8	1.8	-2.1	1.3	-1.5
Qualifications: None of the above	2.6	5.6	13.9	0.4	0.1	-2.7	3.4	-3.7	1.4	-2.0
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.6	-0.3	-0.0	0.1	0.0	-0.4	-0.6
Mouth/teeth dental problems	0.9	1.4	3.6	-1.4	0.9	-0.9	1.9	-1.1	0.6	-1.0
Heart attack	7.8	10.0	16.2	1.0	2.3	-3.6	3.8	-4.0	2.7	-3.6
Allergy	2.4	5.5	11.5	0.9	1.7	-2.5	3.3	-3.4	0.0	-2.6
Pain all over the body in last month	0.3	0.4	1.0	0.5	1.0	-0.3	0.5	-1.0	0.1	-0.2
Diabetes (self-reported)	1.0	1.6	3.9	2.0	-0.5	-1.1	0.7	-1.4	0.4	-1.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.5	-1.2	-0.8	0.4	-0.0	0.2	0.2	0.9
Medication: Ramipril	0.9	1.1	2.1	-0.7	1.4	0.8	1.1	0.8	1.5	0.8
Medication: Simvastatin	1.1	1.6	3.5	0.3	0.6	-1.1	1.7	-1.4	1.1	-1.9
Fluid intelligence score	4.1	8.5	17.1	-2.0	-0.3	4.1	-4.0	3.9	-0.7	2.6
Illnesses of siblings	0.8	1.1	2.4	1.6	1.0	0.3	-1.3	-0.0	-1.5	0.2
Neuroticism score	1.5	3.0	6.3	1.5	-0.5	-1.9	1.1	-2.4	1.2	-2.5
Weight	1.3	6.3	18.4	-1.0	-0.2	1.9	-1.7	2.5	-3.5	4.3
Impedance of arm (right)	0.8	3.9	7.0	0.7	-0.6	-1.4	2.6	-2.1	2.5	-2.6
Arm fat percentage (right)	0.6	2.2	7.5	-0.7	-0.3	-0.0	0.2	0.1	-2.7	2.7
Trunk fat-free mass	1.6	9.5	16.6	-0.6	-0.8	3.6	-3.4	4.1	-2.9	4.0
Hip circumference	0.4	1.8	8.5	-0.8	-0.8	0.5	0.2	0.7	-1.5	2.9
Time employed in main current job	0.8	0.9	2.0	1.0	1.2	-0.9	-0.2	-1.1	-0.4	-1.4
Alcohol intake versus 10 years previously	0.9	1.4	3.1	-1.5	-1.8	1.4	-0.7	0.9	1.1	0.2
Father’s age at death	2.2	3.0	7.3	-0.9	-0.0	2.6	-0.9	2.1	-0.9	2.7
Worrier / anxious feelings	1.0	1.8	3.9	1.4	-1.2	-0.3	2.0	-1.3	1.4	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	1.1	-0.3	-0.3	-0.3	0.1	0.9	0.3
Falls in the last year	0.1	0.1	0.2	0.5	0.3	0.1	0.1	0.0	0.3	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	-0.6	-0.1	0.5	-0.8	-0.2	1.2	0.2
Number of live births	0.5	0.7	1.9	1.2	0.7	0.1	0.4	-0.8	-1.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.5	-0.8	-0.0	1.6	-0.2	1.4	-1.6	1.3
Pulse rate	0.9	1.5	4.6	-0.1	-0.2	1.5	-1.1	0.7	-2.1	1.3
Happiness	0.3	0.3	0.8	0.7	-0.3	0.6	-0.5	0.2	0.4	-0.9
Noisy workplace	0.3	0.4	1.0	0.4	0.4	-0.5	1.0	-0.6	0.8	-0.5
Qualifications: A levels/AS levels or equivalent	3.5	7.8	17.1	-1.8	-1.2	3.5	-3.6	4.1	-1.7	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	0.3	-0.2	1.1	0.3	0.7	1.4	0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.5	0.4	-0.5	-0.1	-0.5	-0.6	0.7
Asthma	1.6	3.2	7.1	0.3	-1.6	1.3	-2.7	2.2	-1.4	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.0	1.0	-0.9	0.3	-0.9	0.0	-0.5	-0.7
Medication: Cholesterol lowering	0.4	0.7	1.9	0.1	-0.5	0.2	1.2	-0.5	1.4	-0.8
Depression (self-reported)	0.6	0.7	3.4	0.6	0.9	-0.3	0.6	-0.4	1.8	-0.0
Medication: Lansoprazole	0.4	0.5	1.5	0.3	-0.2	-0.8	0.5	-1.2	0.7	-0.7
Prospective memory result	1.8	2.2	8.2	-2.9	1.6	-1.0	1.8	-0.3	-0.5	-0.2
Lung cancer (father)	2.4	2.8	9.2	1.0	-1.1	-3.0	0.9	-2.1	0.7	-1.7
Illnesses of mother	0.3	0.4	1.3	-0.6	1.1	0.4	-0.4	0.8	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.4	-0.6	0.3	1.5	0.1	1.2	-1.4	1.4
Pulse wave Arterial Stiffness index	0.6	0.7	2.0	-0.1	-0.1	1.4	-0.7	0.8	-1.3	0.6
Impedance of arm (left)	0.6	2.8	5.9	1.2	-0.6	-1.2	1.9	-1.7	2.4	-2.0
Arm fat mass (right)	0.8	3.5	12.2	-0.8	-0.1	0.8	-0.7	1.1	-3.0	3.5
Trunk predicted mass	1.7	9.6	16.7	-0.5	-0.8	3.6	-3.5	4.1	-2.9	4.0
Standing height	0.5	4.5	11.3	0.1	-0.8	3.1	-1.9	3.4	-0.5	2.5
Length of working week for main job	1.2	1.4	4.2	1.3	0.1	-2.1	0.6	-1.4	-0.1	-1.0
Exposure to tobacco smoke at home	1.1	1.2	3.6	-0.7	0.8	-1.0	1.9	-1.3	0.4	-0.9
Breastfed as a baby	0.5	0.6	1.3	0.1	0.8	-0.7	0.8	-0.4	0.9	-1.1
Tense / ‘highly strung’	1.5	2.5	4.3	-0.1	-1.3	-2.1	1.3	-2.0	1.9	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.6	1.2	-1.3	-0.3	2.2	-1.2	2.6	-1.5
Hair/balding pattern: Pattern 4	0.5	1.1	3.3	-0.8	-1.4	-0.8	1.8	-0.7	-0.5	-0.6
Birth weight of first child	2.4	4.4	9.2	-0.5	-2.0	1.9	-2.3	3.0	-1.8	2.3
Peak expiratory flow (PEF)	0.3	0.7	2.2	0.4	0.3	-0.6	1.5	-1.1	-0.6	-0.4
Pulse wave reflection index	0.3	0.4	1.1	-0.4	0.1	0.4	1.0	-0.6	0.9	-0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.3	0.8	0.6	0.1	0.4	-0.4	-1.0
Loud music exposure frequency	0.6	0.7	1.4	-0.2	0.2	-0.9	1.2	-1.0	-0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	2.8	4.5	10.8	-0.9	-0.4	3.3	-1.9	3.3	-0.8	2.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.4	3.3	1.8	-1.2	0.4	-1.8	0.6	-1.0	-0.3
Blood clot in the leg (DVT)	0.6	0.7	2.6	1.6	-0.7	-0.4	-0.6	-1.0	-0.0	-0.6
Medication: Paracetamol	1.0	1.6	5.0	0.7	-0.3	1.5	-2.2	0.8	-0.6	1.5
Headache pain in last month	3.5	6.1	12.5	-0.6	-1.6	2.8	-3.1	3.5	-1.7	2.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.7	0.7	0.4	-0.0	-0.9	0.6	-1.9	1.1
Glaucoma (self-reported)	0.6	0.7	1.6	-1.2	-1.3	-0.9	-0.9	0.3	-0.2	0.0
Gout (self-reported)	4.5	6.2	12.7	-1.9	1.6	3.6	-1.4	2.8	-2.2	3.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	8.0	0.5	1.1	-0.2	0.2	-0.3	2.8	0.1
Medication: Amlodipine	0.8	1.1	4.1	0.7	0.9	-0.1	1.2	-1.0	2.0	-0.0
Medication: Ventolin 100micrograms inhaler	6.3	8.1	16.0	-1.4	-1.2	2.8	-3.6	4.0	-1.2	3.9
Birth weight	3.0	6.5	10.2	-0.5	-0.5	3.0	-3.2	3.2	-2.8	2.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.7	-0.7	-0.0	-0.3	-0.1	0.2	0.8
High blood pressure (siblings)	0.8	1.2	4.8	-2.2	-0.7	0.1	0.5	0.8	1.1	0.9
Forced vital capacity (FVC), Best measure	0.8	2.9	6.9	-0.8	0.5	2.4	-1.2	2.6	-1.1	2.0
Body fat percentage	0.5	2.0	6.0	-0.8	0.1	-0.7	0.8	-0.6	-2.4	2.4
Leg fat percentage (right)	0.5	1.8	5.7	-0.8	0.2	-1.0	1.1	-1.1	-2.4	1.6
Arm fat-free mass (right)	1.6	8.3	18.0	-1.0	-0.4	3.0	-2.9	3.3	-3.2	4.2
Exposure to tobacco smoke outside home	1.5	2.0	5.5	2.3	1.1	-0.8	0.9	-1.7	-0.0	-1.8
Comparative body size at age 10	0.2	0.7	2.6	0.6	0.2	-1.0	-0.7	-0.0	-1.6	-0.3
Number of full brothers	0.9	1.2	3.3	-0.8	-0.1	1.8	-1.2	1.6	-0.1	0.7
Worry too long after embarrassment	1.0	1.7	5.2	1.2	-0.9	-1.5	-0.8	-1.0	0.8	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	1.2	-1.0	-0.5	0.6	-0.9	0.3	-0.4
Wheeze or whistling in the chest in last year	1.0	1.7	7.4	-0.9	-2.7	-0.1	-1.4	0.8	-0.3	1.1
Number of children fathered	1.6	1.8	5.3	-0.1	0.5	1.6	-0.4	1.3	-1.6	2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.5	0.7	-0.4	-1.9	1.3	-1.5	1.3	-0.7
Age at first live birth	0.7	1.2	5.2	0.3	1.1	1.0	0.5	0.5	2.3	-0.6
Pulse wave peak to peak time	0.6	0.7	2.1	0.0	0.2	-1.4	0.7	-0.7	1.2	-0.6
Health satisfaction	0.5	0.7	1.6	1.3	-1.0	-0.4	0.7	-0.5	0.4	-1.1
Shortness of breath walking on level ground	0.2	0.2	0.5	0.4	-0.7	0.4	-0.6	0.4	-0.0	0.1
Qualifications: College or University degree	1.8	5.7	13.6	-0.2	-1.3	3.7	-2.7	3.7	-1.3	1.4
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.4	-0.8	-0.3	0.7	-0.2	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	1.5	1.7	5.8	0.8	2.4	-0.0	-0.1	-0.3	2.3	-0.6
Emphysema/chronic bronchitis	1.6	1.8	5.7	-1.0	-2.1	-0.2	-2.4	0.9	0.2	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-1.1	1.0	-0.2	0.7	0.5	0.5	-0.1
Neck or shoulder pain in last month	0.7	1.0	1.8	1.3	-0.2	-1.3	-1.3	-0.3	0.2	-1.2
Medication: Blood pressure	0.7	1.3	4.3	-0.4	-0.7	-0.0	1.2	-0.9	2.1	-1.4
Angina (self-reported)	1.2	1.6	2.8	0.6	0.7	-1.5	1.0	-1.7	1.6	-1.3
Migraine (self-reported)	0.4	0.4	1.0	-0.9	-0.7	0.6	-0.3	0.3	0.6	1.0
Medication: Ibuprofen	0.4	0.5	2.1	1.4	-0.1	0.8	-0.7	0.2	0.1	-0.2
Medication: Allopurinol	1.2	1.6	5.1	-1.0	0.6	2.2	-0.9	1.4	-0.3	1.4
Medication: Omeprazole	0.4	0.4	1.2	-1.1	-0.8	-0.3	-0.4	0.3	-0.7	0.7
Medication: Seretide 50 evohaler	0.5	0.6	1.9	0.8	-0.6	0.4	-1.4	0.7	0.2	0.5
Mean time to correctly identify matches	2.0	3.7	10.1	0.3	1.1	-0.7	3.2	-1.4	2.2	-2.7
Heart disease (mother)	1.6	1.9	5.7	-0.6	0.9	-1.0	2.0	-1.2	2.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.5	-0.4	-0.6	0.9	-0.7	-0.2	-0.7
Whole body fat mass	0.8	3.2	11.4	-1.1	-0.2	0.6	-0.3	0.8	-3.0	3.4
Leg fat mass (right)	0.9	3.5	11.2	-1.3	-0.1	0.4	-0.5	0.8	-3.3	3.2
Arm predicted mass (right)	1.6	8.4	17.7	-0.8	-0.3	2.9	-3.0	3.4	-3.3	4.2
Pulse rate, automated reading	0.9	2.9	8.6	-0.5	0.6	2.3	-1.0	0.9	-2.9	2.0
Alcohol intake frequency.	0.5	1.3	6.8	-2.6	0.3	0.6	-0.4	0.3	-0.2	1.2
Comparative height size at age 10	0.3	1.8	4.7	0.8	0.1	2.2	-0.4	1.5	-1.0	2.0
Number of full sisters	0.9	1.1	4.0	0.9	0.2	-0.2	-0.1	-0.7	2.0	-1.6
Suffer from ‘nerves’	2.0	3.1	5.5	2.1	-0.6	-2.3	1.4	-2.0	1.3	-2.0
Overall health rating	0.3	0.6	1.8	0.7	-1.1	-1.3	-0.6	-0.5	0.1	-0.4
Chest pain or discomfort	0.6	0.9	4.9	0.1	0.3	-0.3	1.0	-0.6	2.2	-0.0
Had major operations	2.4	2.8	5.6	-1.5	0.6	1.9	-1.4	1.8	-1.5	2.4
Age at last live birth	0.8	1.2	6.8	-0.1	2.6	0.8	-0.1	0.8	0.5	-0.2
Family relationship satisfaction	0.3	0.3	1.1	0.2	0.6	0.0	-0.9	0.0	0.2	-1.0
Leg pain on walking	0.9	1.1	2.6	0.7	1.5	-0.1	1.6	-0.8	0.1	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	-0.2	-0.8	-0.2	-0.0	0.2	1.1	0.6
Commuting to job workplace: Car/motor vehicle	2.8	3.2	8.7	-1.1	-1.4	1.7	-1.5	1.8	-2.9	1.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.8	-0.9	1.1	0.2	-1.3	0.9	-0.1	1.0
Medication: Aspirin	1.3	1.7	3.8	1.6	-0.5	-1.0	1.2	-2.0	0.5	-1.7
Supplements: Vitamin C	0.6	0.7	1.7	-0.1	-1.0	-1.0	-1.1	-0.4	-0.2	-1.3
Knee pain experienced in last month	0.3	0.5	1.9	-0.5	1.4	0.8	0.4	0.5	0.0	0.8
Hypertension (Self-reported)	0.2	0.5	1.6	-0.9	0.5	1.3	-0.4	0.5	0.4	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.2	-1.6	0.5	0.6	-1.0	1.1	-0.2	1.8
Illnesses of father: Heart disease	10.8	14.9	26.1	3.7	1.1	-4.0	5.1	-4.6	2.1	-4.6
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.2	-1.2	0.7	-0.5	0.7	-0.7	-0.1
Smoking status: Previous	1.4	2.1	9.1	3.0	0.1	-0.9	-0.3	-1.0	0.3	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.4	-1.4	-0.3	1.9	0.2	1.7	-0.6	1.3
Whole body fat-free mass	1.8	10.2	18.4	-0.8	-1.0	3.4	-3.4	4.1	-3.4	4.3
Leg fat-free mass (right)	2.0	10.5	20.3	-1.0	-0.7	3.2	-3.4	4.1	-3.6	4.5
Arm fat percentage (left)	0.6	2.3	7.8	-0.3	-0.4	-0.2	0.0	0.0	-2.8	2.8
Average weekly red wine intake	0.6	0.9	1.4	1.2	0.5	0.6	-1.1	1.2	-1.1	0.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	5.5	0.5	2.3	0.3	-0.9	0.0	0.6	0.4
Mood swings	0.9	1.6	4.0	0.3	-0.1	-0.8	1.8	-2.0	0.5	-1.9
Loneliness, isolation	2.5	3.5	7.0	1.4	1.0	-2.0	2.1	-2.6	1.3	-2.2
Long-standing illness, disability or infirmity	0.7	1.0	2.6	1.5	-1.1	0.8	-0.3	-0.3	1.6	-0.3
Ever had bowel cancer screening	0.3	0.3	0.5	0.3	-0.7	0.7	-0.7	0.4	-0.1	0.7
Diabetes diagnosed by doctor	0.7	1.1	3.2	0.9	-0.7	-0.9	0.9	-1.2	0.6	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.1	0.2	0.6	-0.6	0.2	0.7	-0.2
Friendships satisfaction	0.2	0.3	0.6	-0.8	0.0	0.8	-0.6	0.6	0.2	-0.3
Qualifications: nursing, teaching	1.1	1.7	3.6	-0.8	0.8	1.9	-1.0	1.9	-0.2	1.5
Commuting to job workplace: Walk	0.9	1.0	3.3	-0.2	1.6	-0.5	0.8	-0.3	1.8	-0.4
Eye problems/disorders: Cataract	0.4	0.4	1.0	0.6	0.0	0.7	-1.0	0.9	-0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	6.1	-0.7	-1.6	1.5	-1.9	2.5	-0.5	1.4
Medication for cholesterol	1.1	1.7	5.1	1.2	-2.3	0.7	-1.8	1.2	0.5	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	0.2	0.6	-1.0	0.5	-1.4	-0.7	-0.3
Back pain experienced in last month	0.6	0.8	2.9	0.8	-1.7	-1.4	-0.3	-0.3	-0.4	-0.4
Mineral and other dietary supplements	0.2	0.2	1.1	-1.0	0.4	-0.5	0.1	0.4	0.0	0.2
Breast cancer (self-reported)	0.3	0.4	1.0	0.6	-0.5	1.0	0.0	-0.2	-0.9	0.3
Asthma (self-reported)	1.7	3.4	6.3	0.1	-1.9	1.4	-2.5	2.4	-1.3	2.1
Osteoporosis (self-reported)	0.3	0.4	2.4	-0.0	-0.1	-0.2	0.5	0.1	1.6	0.2
Osteoarthritis (self-reported)	0.6	0.8	1.3	1.0	0.5	-0.7	1.0	-1.1	-0.5	-1.0
Medication: Aspirin	1.3	1.6	3.7	1.5	-0.8	-0.9	1.3	-1.9	0.1	-1.6
Medication: Gliclazide	0.7	0.8	3.3	1.2	-1.8	0.7	-0.1	0.7	0.1	-0.1
Illnesses of father: None of the above (group 1)	3.3	4.0	13.5	-1.0	-0.4	1.8	-3.7	2.5	-0.6	1.9
Smoking status: Current	0.5	0.7	3.1	-1.8	-0.7	-0.8	-0.6	0.2	-0.3	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.2	-1.3	2.5	0.8	1.6	-0.2	-0.0	0.8
Whole body water mass	1.8	10.4	19.6	-0.8	-0.9	3.5	-3.4	4.1	-3.3	4.4
Leg predicted mass (right)	2.0	10.5	20.4	-1.0	-0.9	3.1	-3.4	4.1	-3.6	4.5
Arm fat mass (left)	0.8	3.5	12.1	-0.5	-0.4	0.8	-0.8	1.1	-3.1	3.5
Number of self-reported non-cancer illnesses	0.9	1.6	2.9	0.1	-1.6	1.3	-1.2	0.9	1.7	1.3
Average weekly champagne plus white wine intake	1.3	1.7	5.8	2.4	-0.2	-0.7	0.5	-1.4	0.4	-1.8
Miserableness	2.4	4.2	9.2	-0.1	-0.1	-1.9	2.5	-2.7	3.0	-1.8
Guilty feelings	1.3	2.0	4.9	1.0	-0.5	-1.9	-0.1	-2.2	0.1	-2.1
Wears glasses or contact lenses	0.5	0.6	1.5	-0.6	0.9	0.2	1.2	0.0	1.2	0.2
Ever taken oral contraceptive pill	0.8	0.9	1.6	0.1	1.3	-1.0	0.8	-0.7	1.1	-1.1
Hearing aid user	0.6	0.7	1.7	-0.2	1.3	0.9	0.3	1.2	0.0	0.9
Mother’s age at death	1.8	2.3	4.0	0.8	-0.5	1.7	-2.0	2.0	-1.6	1.2
Financial situation satisfaction	1.8	2.3	5.2	0.7	0.4	-1.6	1.9	-2.3	0.5	-1.9
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.2	-0.1	0.2	0.3	-0.1	-0.1	-0.6
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.6	-0.6	-0.7	0.1	-0.5	0.5	-0.3
Eye problems/disorders: Glaucoma	1.0	1.1	3.3	-1.7	-1.8	-0.1	-1.0	0.4	-0.7	0.2
Medication: Blood pressure	0.9	1.6	5.5	-0.6	2.3	-0.2	1.8	-1.3	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.5	1.2	-0.2	-0.5	-0.6	-0.2	0.9	0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	-0.5	-0.1	1.6	-0.5	0.6	-0.0	1.4
High cholesterol (Self-reported)	0.5	0.9	2.0	-0.7	1.4	-0.7	1.4	-0.5	0.6	-0.6
Medication: Bendroflumethiazide	1.0	1.6	4.9	-1.6	2.2	-0.3	1.1	-0.9	1.2	-0.1
Medication: Paracetamol	1.9	2.9	5.9	0.4	0.2	2.4	-2.4	1.7	-0.7	2.2
Medication: Lisinopril	3.3	4.3	9.2	1.9	1.4	-2.5	1.5	-3.0	0.9	-2.4
Medication: Atorvastatin	0.2	0.2	0.7	0.2	0.7	-0.4	0.8	-0.4	0.2	-0.2
Illnesses of father: High blood pressure	0.8	1.0	3.3	1.2	-1.8	1.1	0.1	0.7	-1.0	0.1
Alcohol drinker status: Never	0.8	0.9	4.0	-2.0	-0.2	0.2	1.0	-0.2	0.8	0.8
Ever smoked	2.0	3.5	8.3	2.9	-2.0	-1.5	-1.8	-0.3	0.7	-2.5
Basal metabolic rate	1.8	9.8	20.2	-1.0	-0.8	3.2	-3.1	3.9	-3.5	4.5
Leg fat percentage (left)	0.5	1.8	6.4	-0.4	0.4	-1.2	0.9	-1.2	-2.5	1.6
Arm fat-free mass (left)	1.5	7.9	15.5	-1.1	-0.1	2.7	-2.8	3.3	-3.4	3.9
Number of operations (self-reported)	2.9	4.3	7.1	0.0	-2.3	1.9	-2.3	2.4	-2.7	1.6
Average weekly beer plus cider intake	1.0	1.5	6.6	-2.6	-0.5	0.0	0.4	-0.3	-1.7	0.7
Irritability	0.3	0.6	2.1	0.3	-1.0	0.4	0.3	-0.6	-0.1	-1.5
Risk taking	0.7	1.0	3.0	-1.0	1.7	-0.9	0.8	-0.6	0.5	-0.8
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	0.7	-0.3	0.4	-0.7	0.7	-0.6	0.0
Fractured/broken bones in last 5 years	0.6	0.8	2.5	0.1	-1.2	1.6	-0.9	1.0	0.1	0.0
Age started oral contraceptive pill	0.8	1.0	3.1	0.1	0.4	-0.8	1.6	-0.6	1.8	0.4
Diastolic blood pressure, automated reading	1.7	5.1	9.5	-2.8	1.8	2.5	-0.2	2.0	-2.2	3.1
Ever depressed for a whole week	1.3	1.7	5.8	1.6	0.6	-0.8	1.0	-0.9	2.4	-0.7
Unable to work because of sickness or disability	0.1	0.2	0.4	0.4	0.5	-0.4	-0.7	0.1	0.4	0.4
Commuting to job workplace: Cycle	1.4	1.6	6.9	1.6	-0.1	0.5	0.5	-0.8	2.6	-1.0
Myopia	0.3	0.4	1.5	-0.6	0.8	-0.2	0.2	0.3	1.2	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	0.5	-0.3	0.2	-0.1	0.7	-0.9	0.7
Cholesterol lowering medication	1.0	1.4	3.3	-0.3	1.8	-1.3	1.7	-1.2	0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	-0.4	0.1	-0.3	-0.5	0.2	-1.2	0.6
Pain experienced in last month	0.5	0.9	1.8	-0.8	0.6	-0.7	1.3	-1.0	1.2	-0.8
Supplements: Calcium	1.6	1.8	8.4	0.7	-2.9	-0.5	-1.4	0.3	0.6	-1.0
Basal cell carcinoma (self-reported)	2.1	2.5	8.9	0.9	-1.2	1.7	-1.7	0.8	-3.0	0.4
Heart attack/myocardial infarction (self-reported)	7.9	10.2	16.9	1.2	2.2	-3.4	3.9	-4.1	2.9	-3.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.8	2.0	-0.9	-1.0	-0.3	-1.4	0.1	-0.9
Heart disease (siblings)	1.8	2.2	5.0	0.0	1.1	-1.7	1.5	-1.7	0.9	-2.2
Alcohol drinker status: Previous	0.4	0.5	1.4	-1.2	-0.2	0.9	-0.2	0.2	0.6	0.9
Pack years of smoking	0.7	1.0	3.3	-0.7	-0.7	-1.8	0.7	-1.4	-0.5	-0.3
Impedance of whole body	0.9	4.5	7.3	0.5	-0.3	-2.0	2.6	-2.6	2.5	-2.7
Leg fat mass (left)	0.9	3.6	13.0	-1.1	-0.1	0.4	-0.6	0.7	-3.6	3.1
Arm predicted mass (left)	1.6	8.3	15.8	-1.1	-0.5	3.0	-3.1	3.5	-3.2	4.0