TWAS hub - ZNF90

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.162	0.0640	1.4e-03	0.166	NA	0.163	NA	0.171	2.6e-08	NA	3.5e-08	NA	1.5e-08
2	GTEx	Lung	0.147	0.0392	4.5e-07	0.103	NA	0.134	NA	0.139	3.0e-08	NA	1.9e-10	NA	8.9e-11
3	GTEx	Skin Not Sun Exposed Suprapubic	0.138	0.0580	3.3e-03	0.039	NA	0.011	NA	0.031	3.2e-03	NA	7.9e-02	NA	8.1e-03
4	GTEx	Skin Sun Exposed Lower leg	0.092	0.0330	1.3e-04	0.058	NA	0.044	NA	0.058	1.5e-05	NA	1.5e-04	NA	1.3e-05
5	GTEx	Thyroid	0.150	0.0520	1.0e-04	0.067	NA	0.063	NA	0.068	7.3e-06	NA	1.4e-05	NA	7.0e-06
6	GTEx	Whole Blood	0.132	0.0460	2.6e-04	0.021	NA	0.033	NA	0.022	4.3e-03	NA	5.1e-04	NA	3.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication: Gliclazide	6.2	7.0	8.4	2.7	2.6	2.4	2.5	2.8	2.9
Chronic bronchitis/emphysema (father)	4.0	4.6	7.3	-2.5	-2.1	-2.5	-1.6	-2.7	-0.9
Multivitamins +/- minerals	3.7	4.6	7.3	1.7	2.6	2.4	2.7	1.9	1.4
Relative age voice broke	3.1	4.7	7.7	-1.9	-2.5	-2.8	-2.5	-1.8	-1.1
Commuting to job workplace: Walk	3.0	3.2	4.4	1.9	1.9	2.1	2.0	1.8	0.5
Mother’s age at death	3.0	3.8	6.6	2.6	1.8	1.9	1.5	2.3	1.2
Pain all over the body in last month	2.9	3.1	6.4	-1.7	-1.7	-1.2	-1.5	-1.7	-2.5
Ever depressed for a whole week	2.9	3.6	7.7	-1.2	-1.9	-1.5	-2.1	-1.5	-2.8
High blood pressure (siblings)	2.4	3.5	5.2	-1.7	-2.3	-2.1	-2.3	-1.8	-0.8
Average weekly spirits intake	2.3	2.9	4.3	-1.6	-2.1	-1.2	-1.8	-1.7	-1.7
Angina (self-reported)	2.3	3.0	5.4	2.0	1.8	2.3	1.5	1.7	0.5
Medication: Aspirin	2.3	3.0	5.1	2.0	1.8	2.3	1.5	1.8	0.8
Angina	2.1	2.8	5.8	1.8	1.8	2.4	1.6	1.5	0.3
Pulse wave Arterial Stiffness index	2.1	2.5	3.5	1.8	1.7	1.7	1.4	1.9	0.6
Fasting Glucose	2.0	2.4	3.7	1.5	1.6	1.6	1.9	1.6	1.1
Pulse wave peak to peak time	2.0	2.4	3.2	-1.6	-1.7	-1.8	-1.5	-1.7	-0.7
Pack years of smoking	2.0	2.9	4.3	1.8	1.7	1.7	1.4	2.1	1.4
Number of live births	1.9	2.6	7.4	-1.4	-1.2	-1.2	-1.2	-1.4	-2.7
Ulcerative Colitis (UC)	1.8	3.3	9.1	-1.6	-1.7	-0.9	-1.7	-1.1	-3.0
Vitamin and mineral supplements	1.8	2.5	3.3	-1.4	-1.8	-1.6	-1.8	-1.8	-0.9
Hayfever, allergic rhinitis or eczema	1.8	3.8	8.0	0.7	2.4	2.8	2.8	0.9	0.1
Number of children fathered	1.8	2.1	5.3	0.2	-1.2	-1.5	-1.8	0.4	-2.3
Eye problems/disorders: Cataract	1.8	2.1	6.2	-0.8	-1.6	-2.5	-1.3	-1.1	0.5
LDL Cholesterol	1.7	2.7	4.1	2.0	1.8	1.5	1.8	1.9	0.3
Lung cancer (father)	1.7	1.9	3.7	1.6	1.4	1.2	1.2	1.9	-0.5
Glaucoma (self-reported)	1.7	2.0	4.9	-2.2	-1.0	-1.1	-0.4	-2.2	0.2
Pain type(s) experienced in last month: Hip pain	1.7	2.2	3.1	-1.7	-1.5	-1.2	-1.3	-1.8	-1.3
Irritable Bowel Disease (IBD)	1.6	3.8	5.5	-2.3	-2.0	-1.1	-1.9	-1.8	-2.3
High blood pressure (mother)	1.6	2.2	2.9	-1.7	-1.5	-1.2	-1.4	-1.5	-1.6
Illnesses of father: None of the above (group 1)	1.6	2.0	2.5	1.2	1.5	1.6	1.5	1.3	1.2
Allergy or Eczema	1.5	3.9	7.5	1.5	2.3	2.7	2.3	1.8	-0.2
Average weekly champagne plus white wine intake	1.5	2.1	3.3	1.8	1.2	1.7	1.2	1.6	0.7
Hearing aid user	1.5	1.7	2.1	-1.4	-1.3	-1.3	-1.3	-1.4	-1.1
Blood Eosinophil Count	1.4	10.5	14.4	2.9	3.3	3.0	3.2	3.8	3.2
Pack years adult smoking proportion	1.4	2.2	2.7	1.4	1.4	1.4	1.2	1.6	1.6
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.6	-0.7	-1.3	-1.5	-1.6	-0.5	-1.6
Bipolar Disorder or Schizophrenia	1.3	3.1	5.1	1.7	1.8	1.8	1.4	2.3	1.5
Major Depression (MDD)	1.3	1.5	4.4	0.3	1.2	2.1	1.5	0.1	0.9
Breast Cancer	1.3	3.1	5.4	-0.6	-2.1	-2.3	-2.3	-1.0	-1.4
Relative age of first facial hair	1.3	2.6	4.4	-1.2	-1.7	-2.1	-1.6	-1.4	-1.6
Medication for hormone replacement therapy	1.3	1.4	3.5	-0.5	-1.5	-1.4	-1.9	-0.5	-0.7
Guilty feelings	1.3	2.0	4.3	-1.5	-1.1	-0.7	-0.7	-1.8	2.1
Ever taken oral contraceptive pill	1.3	1.5	3.6	-1.6	-0.8	-1.0	-0.3	-1.9	-0.8
Worry (Nagel 2018)	1.2	2.5	3.4	-1.9	-1.6	-1.8	-1.2	-1.6	-1.3
Age at First Birth	1.2	1.8	2.7	-1.4	-1.5	-1.6	-1.3	-1.4	0.1
Hearing difficulty/problems: Yes	1.2	1.9	3.3	-0.7	-1.4	-1.4	-1.6	-1.0	-1.8
Impedance of leg (right)	1.2	5.8	8.7	1.7	2.7	2.9	2.5	2.7	1.5
Number of incorrect matches in round	1.2	1.9	4.1	-0.7	-1.5	-1.1	-1.8	-0.5	-2.0
Noisy workplace	1.2	1.5	3.3	-1.8	-0.2	-0.5	0.4	-1.8	-1.4
Commuting to job workplace: Cycle	1.2	1.4	2.6	-0.7	-1.3	-1.4	-1.2	-0.8	-1.6
Schizophrenia (2018)	1.1	2.3	4.1	1.0	1.6	1.4	1.4	1.4	2.0
Blood Platelet Count	1.1	12.2	35.2	4.4	2.2	2.1	0.6	5.9	3.1
Townsend deprivation index at recruitment	1.1	1.5	2.2	1.0	1.5	1.3	1.3	0.9	1.2
Qualifications: None of the above	1.1	2.3	3.8	-1.8	-1.5	-0.6	-1.5	-1.3	-2.0
Hair/balding pattern: Pattern 3	1.1	1.7	5.5	1.2	0.9	0.8	0.9	0.9	2.3
Medication: Aspirin	1.1	1.4	2.2	1.5	1.1	1.5	0.8	1.5	0.3
Average weekly red wine intake	1.1	1.6	5.1	1.9	0.2	-0.0	-0.4	2.3	-0.9
Diabetes diagnosed by doctor	1.1	1.7	5.4	0.6	1.1	1.2	1.3	0.5	2.3
Fractured/broken bones in last 5 years	1.1	1.4	2.6	1.2	1.3	1.6	1.1	1.1	0.7
Pain experienced in last month	1.1	1.9	3.8	1.8	0.6	0.4	0.1	1.9	2.0
Heart disease (siblings)	1.1	1.3	2.7	0.5	1.5	1.4	1.7	0.3	0.6
Crohns Disease (2017)	1.0	2.3	4.9	-2.2	-1.5	-1.0	-1.2	-1.9	-0.5
Lung FVC	1.0	5.0	9.4	-1.0	-2.6	-2.8	-3.1	-1.2	-2.0
Supplements: Zinc	1.0	1.1	2.1	-1.4	0.3	1.1	0.7	-1.1	-1.1
Heart attack	1.0	1.2	3.2	1.1	1.0	1.8	0.7	1.2	-0.0
Diabetes (self-reported)	1.0	1.6	4.6	0.5	1.1	1.2	1.4	0.5	2.1
Arm fat mass (right)	1.0	4.1	9.1	-2.7	-2.0	-1.3	-1.5	-3.0	-0.4
Breastfed as a baby	1.0	1.2	2.6	-0.5	-1.3	-1.2	-1.6	-0.3	-1.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.1	-1.8	-0.3	-0.0	0.1	-1.7	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.2	-1.1	-1.4	-1.5	-1.0	-1.1	0.1
Number of full sisters	1.0	1.2	2.8	-1.7	-0.6	-0.1	-0.3	-1.5	-1.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.4	-1.5	-0.7	-0.8	-0.3	-1.6	-0.9
Unable to work because of sickness or disability	1.0	1.2	2.7	-1.4	-1.2	-0.7	-0.9	-1.6	-0.0
Basal cell carcinoma (self-reported)	1.0	1.2	2.9	-0.2	1.2	1.7	1.5	-0.3	0.8
Neuroticism (Nagel 2018)	0.9	2.1	5.2	-2.3	-1.0	-0.8	-0.4	-2.2	-0.8
Alzheimer’s Disease (including proxy)	0.9	1.3	3.2	-1.8	-0.8	-0.7	-0.5	-1.5	-0.8
Crohns Disease (2012)	0.9	1.4	4.4	-2.1	-0.3	0.2	0.4	-2.0	-0.1
Hypothyroidism (self reported)	0.9	2.0	4.2	-0.7	-1.9	-0.8	-2.0	-1.0	-1.4
Had menopause	0.9	1.1	2.9	-0.6	-1.2	-1.7	-1.2	-0.6	-0.4
Mouth/teeth dental problems: Dentures	0.9	1.6	5.7	-0.3	-1.0	-1.1	-1.1	-0.3	-2.4
Eye problems/disorders: None of the above	0.9	1.1	3.4	0.9	1.1	1.8	0.7	0.8	-0.0
Migraine (self-reported)	0.9	1.1	2.1	0.6	1.4	1.5	1.3	0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.4	-0.0	-1.0	-0.7	-1.5	0.5	-1.5
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.4	1.5	0.7	0.8	0.1	1.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.4	-1.5	-1.0	-0.3	-0.8	-1.3	-0.8
Breast cancer (self-reported)	0.9	1.1	1.7	-1.1	-1.2	-1.3	-1.0	-1.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.6	1.1	1.0	1.9	0.6	1.1	-0.1
Bipolar Disorder (2018)	0.8	1.3	3.8	1.4	0.9	1.0	0.4	1.9	-0.1
Schizophrenia (2014)	0.8	1.8	3.6	0.7	1.5	1.1	1.3	1.1	1.9
Smoking Status	0.8	2.0	3.6	-1.9	-1.2	-1.4	-1.0	-1.7	-1.0
Body mass index (BMI)	0.8	3.3	7.2	-2.2	-1.8	-1.2	-1.5	-2.7	-0.8
Arm fat percentage (right)	0.8	3.2	7.3	-2.5	-1.7	-1.0	-1.2	-2.7	-0.4
Falls in the last year	0.8	1.0	1.4	-1.2	0.6	1.2	1.2	-1.1	0.7
Pulse wave reflection index	0.8	0.9	1.7	1.3	0.9	0.8	0.5	1.3	-0.8
Loud music exposure frequency	0.8	0.8	2.3	-1.5	-0.5	0.2	-0.3	-1.3	-0.8
Family relationship satisfaction	0.8	1.0	2.1	-0.2	-1.1	-1.1	-1.5	-0.5	-1.0
Leg fat-free mass (right)	0.8	4.1	6.8	-2.0	-2.2	-2.2	-1.9	-2.6	-0.6
Leg predicted mass (right)	0.8	4.0	6.8	-2.0	-2.2	-2.2	-1.9	-2.6	-0.6
Risk taking	0.8	1.2	2.0	-1.2	-1.1	-1.4	-1.0	-1.0	-0.8
Diastolic blood pressure, automated reading	0.8	2.4	3.2	-1.8	-1.6	-1.2	-1.6	-1.6	-1.2
Alzheimer’s Disease (in father)	0.7	0.7	1.6	-1.3	-0.7	-0.8	-0.3	-1.2	-0.1
Prostate Cancer	0.7	0.9	1.3	-0.7	-1.1	-1.2	-1.1	-0.4	-1.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	0.7	1.0	0.5	1.1	0.4	1.6
Medication: Metformin	0.7	1.0	4.0	0.4	0.6	0.9	0.7	0.2	2.0
Leg fat-free mass (left)	0.7	3.5	7.2	-2.1	-1.9	-1.8	-1.6	-2.7	-0.2
Trunk fat percentage	0.7	2.9	5.9	-2.4	-1.7	-1.0	-1.3	-2.4	-0.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.4	-0.6	-1.1	-0.7	-1.2	-0.6	-0.9
Impedance of leg (left)	0.7	3.5	6.3	1.5	2.0	2.3	1.8	2.5	0.5
Leg predicted mass (left)	0.7	3.5	6.9	-2.0	-2.0	-1.9	-1.6	-2.6	-0.1
Trunk fat mass	0.7	2.8	6.0	-2.4	-1.7	-1.0	-1.3	-2.4	-0.2
Illnesses of siblings	0.7	0.9	1.3	1.0	1.1	0.9	1.0	1.1	0.4
Time employed in main current job	0.7	0.8	2.4	-1.5	-0.5	0.0	-0.4	-1.3	-0.4
Peak expiratory flow (PEF)	0.7	1.7	2.8	-1.3	-1.3	-1.3	-1.1	-1.7	-1.0
Medication: Amlodipine	0.7	0.9	2.1	-0.2	-1.2	-0.9	-1.4	-0.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.7	1.0	1.6	1.3	1.1	0.4	1.0	1.2	-0.6
Medication: Seretide 50 evohaler	0.7	0.8	1.5	1.2	0.9	0.9	0.6	1.2	-0.3
Illnesses of siblings: Diabetes	0.7	0.9	1.4	-0.9	-1.2	-0.8	-1.2	-0.9	0.4
Smoking status: Previous	0.7	1.1	3.2	-0.7	-1.0	-0.8	-0.9	-0.7	-1.8
Arm fat mass (left)	0.7	3.1	7.1	-2.4	-1.7	-1.0	-1.3	-2.7	-0.3
Miserableness	0.7	1.3	2.9	-0.4	1.2	1.7	1.7	-0.6	-0.2
Supplements: Calcium	0.7	0.7	1.2	-0.9	-1.0	-0.5	-1.1	-0.7	-0.7
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	-1.4	-0.1	-0.2	0.5	-1.3	-0.8
Neuroticism (2016)	0.6	0.9	2.1	0.4	1.1	1.4	1.4	0.3	0.2
Hand grip strength (left)	0.6	1.5	5.7	-0.2	-1.0	-0.4	-1.3	-0.3	-2.4
Diabetes (mother)	0.6	0.8	3.0	0.6	-0.3	0.1	-0.8	0.7	-1.7
Qualifications: CSEs or equivalent	0.6	0.8	2.5	0.0	1.1	0.9	1.6	-0.1	0.2
High blood pressure	0.6	1.7	2.5	-1.0	-1.3	-1.4	-1.1	-1.2	-1.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-0.5	-0.8	-0.5	-0.9	-0.7	-1.3
Medication: Ramipril	0.6	0.7	2.5	0.0	-1.1	-0.8	-1.6	-0.1	-0.3
Medication: Simvastatin	0.6	0.8	2.2	1.5	0.3	0.4	-0.0	1.0	1.2
Father’s age at death	0.6	0.8	1.6	0.2	-0.9	-1.3	-1.0	0.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.0	-1.4	-0.6	-0.6	-0.1	-1.3	0.2
Headache pain in last month	0.6	1.0	2.2	-1.1	0.9	0.9	1.5	-1.0	-0.3
Body fat percentage	0.6	2.2	5.1	-2.2	-1.4	-0.5	-1.0	-2.3	-0.3
Wheeze or whistling in the chest in last year	0.6	1.0	2.2	-1.2	-0.8	-1.1	-0.5	-1.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	-0.1	-1.0	-0.8	-1.2	0.1	-0.9
Age at first live birth	0.6	1.0	3.3	1.8	0.1	0.1	-0.2	1.7	-0.0
Shortness of breath walking on level ground	0.6	0.7	1.4	0.2	1.0	0.8	1.1	0.1	1.2
Qualifications: College or University degree	0.6	1.8	4.2	1.8	0.9	0.8	0.6	1.4	2.1
Medication: Omeprazole	0.6	0.8	2.0	-1.1	-0.9	0.0	-0.8	-1.4	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-0.2	0.8	1.1	1.1	-0.2	0.9
Whole body fat mass	0.6	2.7	6.2	-2.3	-1.6	-0.8	-1.2	-2.5	-0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	-0.4	-0.8	-0.8	-1.1	-0.5	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	-1.1	-0.7	-0.1	-0.5	-1.3	-1.0
Arm fat percentage (left)	0.6	2.4	6.1	-2.2	-1.4	-0.7	-1.0	-2.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.7	-0.4	-1.3	-1.1	-1.6	-0.7	-0.8
Financial situation satisfaction	0.6	0.7	2.0	-0.6	-0.7	-1.4	-0.7	-0.8	-0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	-1.2	-0.1	-0.4	0.5	-1.2	0.9
Medication: Bendroflumethiazide	0.6	0.8	1.7	-0.1	-1.2	-1.2	-1.3	-0.2	-0.6
Irritability	0.6	1.0	1.5	-1.2	0.5	1.2	1.1	-1.2	0.3
Myopia	0.6	0.9	1.4	-1.1	-0.8	-1.0	-0.4	-0.9	1.2
Impedance of whole body	0.6	2.9	4.2	1.2	1.8	2.0	1.7	2.1	1.4
Reaction Time	0.5	0.9	1.4	1.0	1.0	0.6	0.8	1.0	1.2
Ulcerative Colitis	0.5	0.8	3.2	-0.7	-0.6	-0.3	-0.5	-0.5	-1.8
BMI	0.5	2.9	7.3	-2.0	-1.7	-1.3	-1.0	-2.7	-0.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.6	0.5	0.7	1.2	0.9	0.3	1.6
Neuroticism	0.5	1.2	3.0	-1.7	-0.8	-0.3	-0.2	-1.7	-0.6
Number of treatments/medications taken	0.5	0.9	2.6	0.7	1.0	1.6	0.9	0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	0.9	0.6	0.9	0.0	0.8	1.2
Medication: Co-codamol	0.5	0.5	2.5	0.4	-0.2	-0.1	-0.5	0.5	-1.6
Taking other prescription medications	0.5	0.7	1.9	0.1	0.8	1.4	0.7	0.3	1.1
Financial difficulties in last 2 years	0.5	0.6	1.8	0.1	0.9	-0.0	1.4	-0.1	1.0
Allergy	0.5	1.1	3.6	0.3	-1.3	-1.1	-1.9	0.2	0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.2	1.0	1.2	1.3	-0.2	0.3
Weight	0.5	2.5	5.1	-1.9	-1.6	-1.2	-1.4	-2.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.1	-0.7	-1.6	-1.6	-1.8	-1.1	-0.7
Tense / ‘highly strung’	0.5	0.8	1.8	-1.3	-0.6	-0.5	-0.1	-1.3	-1.0
Blood clot in the leg (DVT)	0.5	0.7	1.7	-1.2	-0.3	-0.5	0.2	-1.3	-0.7
Exposure to tobacco smoke outside home	0.5	0.7	1.8	-1.4	-0.3	-0.3	-0.1	-1.3	0.5
Comparative body size at age 10	0.5	1.5	2.6	-1.0	-1.1	-0.9	-1.0	-1.5	-1.6
Emphysema/chronic bronchitis	0.5	0.5	1.7	1.0	0.2	0.6	-0.1	1.3	0.2
Knee pain experienced in last month	0.5	0.7	1.3	-1.0	-0.7	-0.7	-0.5	-1.1	-0.9
Hypertension (Self-reported)	0.5	1.3	2.2	-0.6	-1.2	-1.3	-1.1	-0.8	-1.5
Illnesses of father: Heart disease	0.5	0.8	2.8	0.7	0.7	0.5	0.5	0.5	1.7
Mood swings	0.5	0.9	2.2	-0.2	1.1	1.3	1.5	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	-0.5	-0.9	-0.7	-0.9	-0.6	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.6	0.7	0.7	0.5	0.7	0.6	1.2
Medication: Lisinopril	0.5	0.6	1.2	1.1	-0.4	-0.3	-0.8	1.1	0.6
Illnesses of father: High blood pressure	0.5	0.6	0.9	-0.5	-0.8	-0.7	-0.9	-0.6	-0.8
Alcohol drinker status: Never	0.5	0.6	2.0	0.5	0.5	0.9	0.2	0.6	-1.4
Age started oral contraceptive pill	0.5	0.7	1.3	0.8	0.6	0.5	0.5	1.2	1.1
Leg fat mass (left)	0.5	1.9	4.5	-1.9	-1.2	-0.5	-0.9	-2.1	-0.7
Depression (Nagel 2018)	0.4	0.6	1.1	0.8	0.8	0.7	1.1	0.7	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.7	-0.3	-1.4	-1.2	-1.6	-0.5	-0.5
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	-1.0	-0.4	-0.2	-0.1	-0.9	-0.7
Ovarian Cancer	0.4	0.5	2.4	-0.4	0.1	-0.1	0.5	-0.5	1.5
Blood Red Count	0.4	3.9	5.2	-1.2	-2.2	-2.1	-2.1	-1.6	-2.3
Waist Hip Ratio (WHR)	0.4	1.8	2.9	1.7	0.9	1.4	0.7	1.5	1.6
Severe depression (siblings)	0.4	0.5	0.9	-0.0	0.7	0.9	0.8	0.3	0.8
Fed-up feelings	0.4	0.8	1.8	-0.1	1.2	1.2	1.3	0.2	0.1
Age when periods started (menarche)	0.4	1.0	2.9	1.3	0.5	0.3	0.1	1.7	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.3	-0.3	-1.2	-0.8	-1.5	-0.4	-1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.6	-0.8	-0.8	-0.6	-0.7	-0.6	-0.6
Stomach or abdominal pain in last month	0.4	0.6	1.0	-1.0	-0.3	-0.5	-0.1	-1.0	-1.0
Medication: Levothyroxine sodium	0.4	0.7	1.9	0.6	0.1	1.4	-0.5	0.8	-0.9
Mouth/teeth dental problems	0.4	0.6	2.7	0.1	-0.2	-0.8	-0.1	0.1	1.6
Hip circumference	0.4	1.9	4.3	-1.9	-1.4	-0.8	-1.1	-2.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.2	-0.7	-0.4	-0.6	-0.0	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.9	-0.3	-1.5	-1.6	-1.7	-0.6	-0.5
Impedance of arm (left)	0.4	1.9	2.7	1.0	1.3	1.4	1.4	1.5	1.6
Length of working week for main job	0.4	0.5	2.6	0.3	0.2	0.0	0.1	0.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	0.2	1.0	0.5	1.3	0.0	1.1
Birth weight of first child	0.4	0.6	1.6	-0.4	-0.7	-1.0	-0.6	-0.5	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	0.2	0.9	0.6	1.2	0.2	0.9
Medication: Paracetamol	0.4	0.6	1.4	-1.2	-0.4	-0.6	-0.1	-1.1	-0.8
Health satisfaction	0.4	0.5	0.9	-0.7	-0.5	-0.3	-0.6	-0.9	-1.0
Leg fat mass (right)	0.4	1.5	4.1	-1.8	-0.9	-0.2	-0.6	-2.0	-0.2
Age at last live birth	0.4	0.6	1.9	1.4	0.3	0.6	-0.1	1.2	-0.4
Leg pain on walking	0.4	0.5	0.9	-0.8	0.4	0.3	0.6	-1.0	-0.8
Whole body fat-free mass	0.4	2.0	4.0	-1.5	-1.4	-1.5	-1.2	-2.0	-0.3
Loneliness, isolation	0.4	0.6	2.4	0.6	0.3	0.2	0.4	0.6	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-1.0	-0.5	-0.3	-0.4	-0.8	-0.9
Smoking status: Current	0.4	0.7	1.2	-1.1	-0.8	-0.8	-0.8	-0.9	0.1
High cholesterol (Self-reported)	0.4	0.7	1.7	1.3	0.6	0.6	0.7	0.7	1.0
Medication: Paracetamol	0.4	0.6	1.3	-1.1	-0.2	-0.5	-0.0	-1.1	-1.0
Basal metabolic rate	0.4	2.3	4.8	-1.7	-1.5	-1.4	-1.2	-2.2	-0.4
Arm fat-free mass (left)	0.4	2.3	4.0	-1.6	-1.6	-1.5	-1.4	-2.0	-0.5
Cholesterol lowering medication	0.4	0.5	1.7	0.9	-0.2	-0.4	-0.4	0.7	1.3
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	-1.0	0.2	0.7	0.9	-1.1	-0.5
Mean Putamen Volume	0.3	0.3	1.4	0.1	-0.2	-0.6	-0.3	0.4	-1.2
Triglycerides	0.3	0.5	1.0	-0.5	-0.8	-0.7	-0.7	-1.0	-0.1
Hand grip strength (right)	0.3	0.7	3.3	0.3	-0.4	-0.3	-0.8	0.2	-1.8
Current tobacco smoking	0.3	0.4	1.2	-1.1	-0.4	-0.4	-0.4	-0.9	0.3
Maternal smoking around birth	0.3	0.4	0.8	-0.9	0.4	0.8	0.5	-0.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.5	0.8	0.5	0.8	0.6	0.5
Medication: Atenolol	0.3	0.4	0.8	0.9	-0.0	0.4	-0.4	0.8	-0.8
Waist circumference	0.3	1.0	2.4	-1.2	-1.1	-0.5	-1.0	-1.6	0.3
Hearing difficulty/problems with background noise	0.3	0.5	0.8	-0.9	-0.5	-0.3	-0.7	-0.7	-0.8
Forced vital capacity (FVC)	0.3	1.2	2.8	-0.2	-1.4	-1.7	-1.5	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.2	-0.5	-0.8	-0.2	-0.8	-0.5	-1.5
Neuroticism score	0.3	0.6	1.2	-1.1	0.1	0.5	0.6	-1.0	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-0.5	-0.6	-1.0	-0.6	-0.4	-0.9
Worrier / anxious feelings	0.3	0.6	1.7	0.5	0.6	0.6	0.6	0.5	1.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	2.9	0.2	-0.1	-0.7	0.1	0.0	1.7
Depression (self-reported)	0.3	0.3	0.9	0.0	-0.9	-0.4	-1.0	-0.2	0.2
Medication: Lansoprazole	0.3	0.4	0.9	0.3	-0.6	-0.7	-0.8	0.2	-0.9
Illnesses of mother	0.3	0.3	1.6	-0.0	0.0	-0.6	0.2	-0.1	1.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.2	-0.9	-1.1	-0.6	-1.1	-0.8	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.0	0.1	-0.6	-0.6	-0.8	-0.1	-1.0
Medication: Blood pressure	0.3	0.5	0.8	-0.6	-0.9	-0.3	-0.8	-0.9	0.3
Mean time to correctly identify matches	0.3	0.5	1.0	1.0	0.7	0.4	0.3	1.0	0.6
Heart disease (mother)	0.3	0.4	1.1	0.1	0.6	1.1	0.9	0.1	-0.2
Pulse rate, automated reading	0.3	1.0	2.4	-0.4	1.0	0.9	1.2	-0.3	1.5
Had major operations	0.3	0.3	0.8	0.5	-0.4	-0.7	-0.9	0.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.1	0.1	0.5	0.4	0.6	0.3	-1.0
Ever had bowel cancer screening	0.3	0.3	0.5	0.4	0.7	0.6	0.7	0.7	-0.0
Friendships satisfaction	0.3	0.4	0.7	0.6	0.8	0.6	0.6	0.6	0.1
Qualifications: nursing, teaching	0.3	0.5	3.0	0.2	-0.2	-0.2	-0.2	-0.2	1.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.2	0.1	0.7	1.5	0.6	0.3	-0.1
Medication for cholesterol	0.3	0.5	1.5	-0.2	0.9	0.8	1.2	-0.2	-0.1
Osteoporosis (self-reported)	0.3	0.4	1.6	0.3	0.2	0.6	0.1	0.1	1.3
Whole body water mass	0.3	1.9	3.9	-1.5	-1.4	-1.4	-1.2	-2.0	-0.3
Wears glasses or contact lenses	0.3	0.4	1.0	0.4	-0.6	-0.7	-1.0	0.4	-0.1
Commuting to job workplace: Public transport	0.3	0.4	1.5	-0.5	-0.2	-0.3	0.0	-0.6	1.2
Leg fat percentage (left)	0.3	1.0	2.3	-1.5	-0.8	0.1	-0.6	-1.5	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.2	0.6	1.0	0.8	0.9	0.9	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	-0.9	-0.1	-0.3	0.4	-1.0	-0.4
Arm predicted mass (left)	0.3	1.3	2.9	-1.4	-1.1	-0.9	-1.0	-1.7	-0.5
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.7	0.5	0.4	0.4	0.4	-0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.3	-0.0	0.0	0.3	-0.5	-0.9
Lupus	0.2	0.3	0.7	0.9	0.4	0.1	0.2	0.7	0.4
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.8	-0.3	-0.4	-0.2	-0.6	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.2	0.4	0.6	0.8	0.3	0.6
Systolic blood pressure, automated reading	0.2	0.6	1.5	-0.7	-0.7	-0.7	-0.7	-0.4	-1.2
Diabetes (father)	0.2	0.2	0.6	0.3	0.6	0.2	0.8	0.3	0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.5	-0.1	0.2	-0.1	-0.7	0.9
Supplements: Glucosamine	0.2	0.2	0.4	-0.6	0.1	0.1	0.5	-0.7	0.5
Past tobacco smoking	0.2	0.3	0.8	0.6	0.6	0.3	0.5	0.5	0.9
Nervous feelings	0.2	0.3	0.6	-0.4	-0.7	-0.8	-0.5	-0.2	-0.7
Had other major operations	0.2	0.3	0.5	0.4	0.7	0.6	0.6	0.4	0.2
Impedance of arm (right)	0.2	0.9	2.6	0.2	0.8	0.8	1.0	0.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	-0.9	-0.3	-0.3	-0.2	-0.8	0.9
Asthma	0.2	0.4	1.4	-0.5	-0.2	-1.2	0.3	-0.7	-0.3
Prospective memory result	0.2	0.3	0.5	0.5	0.4	0.2	0.2	0.7	0.7
Gout (self-reported)	0.2	0.3	0.6	0.5	-0.2	0.1	-0.8	0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.2	0.2	-0.6	0.5	-1.1	0.2	-1.0
Forced vital capacity (FVC), Best measure	0.2	0.8	1.8	0.3	-1.0	-1.4	-1.3	0.1	0.0
Leg fat percentage (right)	0.2	0.8	2.1	-1.5	-0.4	0.5	-0.2	-1.5	0.1
Arm fat-free mass (right)	0.2	1.1	2.0	-1.1	-1.1	-1.0	-1.0	-1.4	-0.5
Worry too long after embarrassment	0.2	0.4	1.0	0.0	0.4	0.9	0.4	0.1	1.0
Neck or shoulder pain in last month	0.2	0.3	0.6	0.6	0.5	0.2	0.3	0.8	-0.7
Medication: Allopurinol	0.2	0.3	0.8	-0.1	-0.4	-0.3	-0.8	-0.0	-0.9
Arm predicted mass (right)	0.2	0.9	1.9	-1.0	-1.0	-0.8	-0.9	-1.4	-0.2
Chest pain or discomfort	0.2	0.3	0.7	-0.5	-0.3	-0.9	-0.1	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	-1.1	-0.5	-0.4	-0.2	-1.0	-0.7
Asthma (self-reported)	0.2	0.4	1.6	-0.6	-0.3	-1.2	0.1	-0.8	-0.2
Osteoarthritis (self-reported)	0.2	0.2	0.5	0.4	0.7	0.6	0.7	0.1	-0.1
Medication: Blood pressure	0.2	0.4	1.2	1.0	0.1	-0.3	-0.4	1.1	-0.1
Number of operations (self-reported)	0.2	0.4	0.9	-0.5	-0.4	-0.6	-0.4	-1.0	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.2	-0.6	-0.5	-0.6	-0.4	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.9	1.0	0.0	0.2	-0.3	0.7	0.2
HbA1C	0.1	0.1	0.2	-0.1	0.4	-0.3	0.1	0.2	0.3
HDL Cholesterol	0.1	0.2	0.9	0.0	-0.1	-0.3	-0.1	0.1	-0.9
Rheumatoid Arthritis	0.1	0.2	0.6	0.2	0.5	0.1	0.4	0.2	0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	0.1	0.3	-0.2	0.3	0.3
Blood White Count	0.1	0.8	1.7	0.9	0.8	0.7	0.7	1.3	0.7
Heel T-Score	0.1	0.4	1.3	-0.5	-0.5	-0.6	-0.5	-0.5	-1.1
Cardiovascular Disease	0.1	0.4	1.1	-0.7	-0.6	-0.7	-0.2	-1.0	-0.0
Lung FEV1/FVC ratio	0.1	0.6	1.2	-0.7	-0.7	-0.2	-0.8	-1.1	-0.6
Chronotype (morning person)	0.1	0.2	0.4	0.5	-0.4	-0.6	-0.6	0.3	0.2
Tanning	0.1	0.9	1.1	1.1	0.9	0.7	0.8	1.0	1.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.1	-0.0	0.0	0.0	-0.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.1	-0.2	-0.3	-0.1	-0.2	0.6
Average weekly fortified wine intake	0.1	0.1	0.3	-0.4	-0.1	0.5	-0.0	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.5	-0.4	-0.2	-0.0	-0.2	-0.6	-0.7
Alcohol usually taken with meals	0.1	0.1	0.3	0.3	0.4	0.2	0.5	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.4	0.6	0.2	0.4	0.3	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	-0.4	0.2	-0.1	0.6	-0.3	-0.7
Fluid intelligence score	0.1	0.2	0.7	0.9	0.1	0.2	-0.3	0.7	0.1
Trunk fat-free mass	0.1	0.7	1.8	-0.9	-0.8	-0.9	-0.6	-1.4	-0.3
Happiness	0.1	0.1	0.4	0.3	0.2	-0.0	0.1	0.2	-0.6
Medication: Cholesterol lowering	0.1	0.1	0.3	0.5	0.0	0.1	0.1	-0.1	0.5
Trunk predicted mass	0.1	0.7	1.7	-0.9	-0.8	-0.8	-0.6	-1.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.3	0.3	0.5	0.3	-0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	-0.3	-0.1	-0.4	-0.0	0.2	-0.9
Number of full brothers	0.1	0.2	0.3	-0.4	-0.2	-0.5	-0.0	-0.5	-0.5
Medication: Ibuprofen	0.1	0.1	0.4	-0.3	-0.1	-0.6	0.2	-0.2	0.2
Alcohol intake frequency.	0.1	0.2	0.8	0.0	0.4	0.5	0.2	0.0	-0.9
Suffer from ‘nerves’	0.1	0.2	0.4	-0.6	-0.4	-0.4	-0.3	-0.6	-0.0
Overall health rating	0.1	0.1	0.3	-0.5	0.0	0.4	0.1	-0.5	-0.2
Supplements: Vitamin C	0.1	0.2	0.4	0.2	0.5	0.2	0.7	0.4	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.5	-0.1	0.2	0.3	0.4	-0.4	0.7
Back pain experienced in last month	0.1	0.2	0.5	0.2	-0.6	0.1	-0.7	-0.2	-0.5
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	-0.4	-0.5	-0.5	0.0	-0.3
Medication: Atorvastatin	0.1	0.1	0.5	-0.2	-0.3	-0.4	-0.0	-0.7	0.1
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.7	0.1	0.5	0.1	-0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	-0.4	-0.3	0.4	-0.3	-0.7	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.2	-0.3	-0.1
Height	0.0	0.1	0.3	-0.0	-0.2	-0.6	-0.2	0.5	-0.0
Systolic Blood Pressure	0.0	0.2	1.2	-0.2	0.2	0.2	0.1	0.2	1.1
Respiratory disease	0.0	0.1	0.2	0.3	0.2	-0.4	0.4	0.3	0.3
Hair Pigment	0.0	0.1	0.3	0.1	0.5	0.4	0.6	0.1	-0.2
Sitting height	0.0	0.1	0.2	0.1	-0.1	-0.4	-0.1	0.4	0.0
Pulse rate	0.0	0.1	0.2	-0.0	0.3	-0.2	0.5	-0.0	0.3
Standing height	0.0	0.3	1.1	0.3	0.2	-0.0	0.2	0.7	1.1
Exposure to tobacco smoke at home	0.0	0.1	0.2	-0.1	0.2	0.2	0.2	0.1	0.4
Birth weight	0.0	0.1	0.2	-0.2	0.0	-0.4	0.1	-0.4	0.5
Medication for pain relief, constipation, heartburn	0.0	0.1	0.2	-0.1	-0.3	-0.3	-0.4	0.0	-0.1
Comparative height size at age 10	0.0	0.2	0.4	-0.5	0.1	0.3	0.2	-0.7	0.4
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	-0.1	0.0	0.4	0.1	-0.4	-0.4
Ever smoked	0.0	0.0	0.1	-0.2	0.1	0.3	0.2	-0.1	0.3

Hub : Genes

ZNF90

Models

Trait associations