Hub : Traits :

Medication: Lansoprazole

2 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 97816039 99315838 1 1 3.8e-08 2.6e-08 1 100 DCBLD2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Ulcerative Colitis (UC) 3.03 1 0 0.0 0 1 DCBLD2
Fasting Glucose 5.83 1 0 0.0 0 1 DCBLD2
Blood Eosinophil Count 0.76 1 0 0.0 0 1 DCBLD2
Heel T-Score 0.90 1 0 0.0 0 1 DCBLD2
Height 2.00 1 1 2.2 0 1 DCBLD2
Systolic Blood Pressure 1.50 1 0 0.0 0 1 DCBLD2
Allergy or Eczema 4.20 1 0 0.0 0 1 DCBLD2
Lung FVC 4.85 1 0 0.0 0 1 DCBLD2
Tanning 1.40 1 0 0.0 0 1 DCBLD2
Leg fat-free mass (left) 1.35 1 0 0.0 0 1 DCBLD2
Taking other prescription medications 4.77 1 0 0.0 0 1 DCBLD2
Hayfever, allergic rhinitis or eczema 4.37 1 0 0.0 0 1 DCBLD2
Sitting height 1.76 1 0 0.0 0 1 DCBLD2
Leg predicted mass (left) 1.44 1 0 0.0 0 1 DCBLD2
Allergy 5.27 1 0 0.0 0 1 DCBLD2
Impedance of arm (right) 6.68 1 1 2.2 0 1 DCBLD2
Arm fat percentage (right) 1.30 1 0 0.0 0 1 DCBLD2
Trunk fat-free mass 5.02 1 1 2.2 0 1 DCBLD2
Pulse rate 3.18 1 0 0.0 0 1 DCBLD2
Asthma 2.56 1 0 0.0 0 1 DCBLD2
Impedance of arm (left) 5.98 1 1 2.2 0 1 DCBLD2
Trunk predicted mass 4.99 1 1 2.2 0 1 DCBLD2
Standing height 2.60 1 0 0.0 0 1 DCBLD2
Birth weight of first child 3.20 1 0 0.0 0 1 DCBLD2
Arm fat-free mass (right) 5.88 1 1 2.2 0 1 DCBLD2
Wheeze or whistling in the chest in last year 3.73 1 0 0.0 0 1 DCBLD2
Arm predicted mass (right) 5.68 1 1 2.2 0 1 DCBLD2
Comparative height size at age 10 5.22 1 1 2.2 0 1 DCBLD2
Whole body fat-free mass 3.65 1 0 0.0 0 1 DCBLD2
Leg fat-free mass (right) 1.72 1 0 0.0 0 1 DCBLD2
Long-standing illness, disability or infirmity 5.95 1 0 0.0 0 1 DCBLD2
Osteoporosis (self-reported) 5.38 1 0 0.0 0 1 DCBLD2
Whole body water mass 3.73 1 0 0.0 0 1 DCBLD2
Leg predicted mass (right) 1.73 1 0 0.0 0 1 DCBLD2
Medication: Bendroflumethiazide 3.63 1 0 0.0 0 1 DCBLD2
Basal metabolic rate 2.69 1 0 0.0 0 1 DCBLD2
Arm fat-free mass (left) 5.21 1 1 2.2 0 1 DCBLD2
Impedance of whole body 2.97 1 0 0.0 0 1 DCBLD2
Arm predicted mass (left) 4.55 1 0 0.0 0 1 DCBLD2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.1
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 1 0.108 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.1
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.1
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.1
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.0
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.0
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2