Hub : Traits :

Osteoporosis (self-reported)

8 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 239954252 241470634 1 1 7.5e-08 5.3e-07 0.1070 90 GREM2
2 4 88199484 89590831 1 1 1.1e-09 1.2e-10 0.0041 80 SPP1
3 7 119935156 121634913 1 1 1.2e-10 1.1e-13 0.0002 75 CPED1
4 11 67533195 69154873 3 2 6.5e-09 9.6e-12 0.0008 76 GAL PPP6R3
5 12 53414010 53932834 1 1 1.2e-07 2.5e-07 0.2690 95 ESPL1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Schizophrenia vs Biploar Disorder 1.93 1 0 0.0 0.00 1.000 GAL
Fasting Glucose 2.52 1 0 0.0 0.00 1.000 GREM2
Ulcerative Colitis 1.34 1 0 0.0 0.00 1.000 GREM2
Blood Eosinophil Count 0.71 2 0 0.0 0.00 1.000 GAL PPP6R3
Blood Platelet Count 0.33 1 0 0.0 0.00 1.000 CPED1
Blood Red Count 1.11 3 1 2.2 0.00 1.000 ESPL1 GREM2 PPP6R3
Heel T-Score 148.50 6 6 13.3 -0.75 0.088 CPED1 ESPL1 GAL GREM2 PPP6R3 SPP1
BMI 1.15 3 0 0.0 0.00 1.000 CPED1 GAL PPP6R3
Height 2.64 4 3 6.7 -0.96 0.037 GAL GREM2 PPP6R3 SPP1
Waist Hip Ratio (WHR) 2.16 2 2 4.4 0.00 1.000 CPED1 PPP6R3
Cardiovascular Disease 0.79 1 0 0.0 0.00 1.000 CPED1
Lung FEV1/FVC ratio 0.69 1 0 0.0 0.00 1.000 CPED1
Lung FVC 0.66 1 0 0.0 0.00 1.000 PPP6R3
Hair Pigment 0.48 2 1 2.2 0.00 1.000 GAL PPP6R3
Hand grip strength (left) 1.12 1 0 0.0 0.00 1.000 PPP6R3
Number of treatments/medications taken 1.39 1 0 0.0 0.00 1.000 CPED1
Impedance of leg (right) 3.82 3 1 2.2 0.00 1.000 CPED1 GAL PPP6R3
Leg fat-free mass (left) 5.12 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Taking other prescription medications 2.29 1 0 0.0 0.00 1.000 CPED1
Age when periods started (menarche) 0.97 1 0 0.0 0.00 1.000 SPP1
Heel bone mineral density (BMD) T-score, automated (left) 103.39 6 6 13.3 -0.76 0.082 CPED1 ESPL1 GAL GREM2 PPP6R3 SPP1
Hayfever, allergic rhinitis or eczema 1.34 1 0 0.0 0.00 1.000 PPP6R3
Medication: Levothyroxine sodium 1.20 1 0 0.0 0.00 1.000 PPP6R3
Sitting height 2.99 5 2 4.4 -0.92 0.029 CPED1 GAL GREM2 PPP6R3 SPP1
High blood pressure (mother) 2.53 1 0 0.0 0.00 1.000 ESPL1
Body mass index (BMI) 0.87 1 0 0.0 0.00 1.000 PPP6R3
Impedance of leg (left) 4.25 4 1 2.2 0.87 0.131 CPED1 GAL GREM2 PPP6R3
Leg predicted mass (left) 5.12 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Forced vital capacity (FVC) 2.75 2 1 2.2 0.00 1.000 GAL PPP6R3
Heel bone mineral density (BMD) T-score, automated (right) 102.43 6 4 8.9 -0.75 0.083 CPED1 ESPL1 GAL GREM2 PPP6R3 SPP1
Allergy 1.29 1 0 0.0 0.00 1.000 PPP6R3
Medication: Simvastatin 2.26 1 0 0.0 0.00 1.000 CPED1
Weight 2.88 3 1 2.2 0.00 1.000 CPED1 GAL PPP6R3
Impedance of arm (right) 1.99 2 1 2.2 0.00 1.000 GAL PPP6R3
Trunk fat-free mass 5.25 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Hip circumference 1.29 2 0 0.0 0.00 1.000 CPED1 PPP6R3
Alcohol intake versus 10 years previously 1.76 1 0 0.0 0.00 1.000 PPP6R3
Falls in the last year 1.49 1 0 0.0 0.00 1.000 CPED1
Forced expiratory volume in 1-second (FEV1) 2.88 2 1 2.2 0.00 1.000 GAL PPP6R3
Noisy workplace 2.14 1 0 0.0 0.00 1.000 PPP6R3
Mouth/teeth dental problems: Dentures 1.66 1 0 0.0 0.00 1.000 SPP1
Medication: Ibuprofen (e.g. Nurofen) 2.13 1 0 0.0 0.00 1.000 PPP6R3
Illnesses of mother 1.47 1 0 0.0 0.00 1.000 ESPL1
Forced expiratory volume in 1-second (FEV1), Best measure 2.25 2 0 0.0 0.00 1.000 GAL PPP6R3
Pulse wave Arterial Stiffness index 1.25 1 0 0.0 0.00 1.000 ESPL1
Impedance of arm (left) 1.64 1 1 2.2 0.00 1.000 PPP6R3
Arm fat mass (right) 0.92 1 0 0.0 0.00 1.000 PPP6R3
Trunk predicted mass 5.28 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Standing height 2.76 4 2 4.4 -0.96 0.045 GAL GREM2 PPP6R3 SPP1
Birth weight of first child 1.62 1 0 0.0 0.00 1.000 PPP6R3
Peak expiratory flow (PEF) 2.96 2 0 0.0 0.00 1.000 GAL PPP6R3
Qualifications: O levels/GCSEs or equivalent 1.65 1 0 0.0 0.00 1.000 CPED1
Gout (self-reported) 11.90 1 1 2.2 0.00 1.000 SPP1
Hypothyroidism/myxoedema (self-reported) 1.62 1 0 0.0 0.00 1.000 PPP6R3
Birth weight 1.94 1 0 0.0 0.00 1.000 PPP6R3
Forced vital capacity (FVC), Best measure 2.22 2 0 0.0 0.00 1.000 GAL PPP6R3
Arm fat-free mass (right) 4.53 2 2 4.4 0.00 1.000 GAL PPP6R3
Comparative body size at age 10 2.03 1 0 0.0 0.00 1.000 PPP6R3
Pulse wave peak to peak time 1.66 1 0 0.0 0.00 1.000 ESPL1
Qualifications: College or University degree 0.72 1 0 0.0 0.00 1.000 PPP6R3
Medication for pain relief, constipation, heartburn 1.48 1 0 0.0 0.00 1.000 CPED1
Medication: Blood pressure 1.39 1 0 0.0 0.00 1.000 CPED1
Medication: Allopurinol 10.09 1 1 2.2 0.00 1.000 SPP1
Arm predicted mass (right) 4.50 3 2 4.4 0.00 1.000 ESPL1 GAL PPP6R3
Alcohol intake frequency. 1.54 1 0 0.0 0.00 1.000 PPP6R3
Comparative height size at age 10 2.19 3 1 2.2 0.00 1.000 GAL PPP6R3 SPP1
Forced expiratory volume in 1-second (FEV1), predicted 1.53 1 0 0.0 0.00 1.000 PPP6R3
Whole body fat-free mass 5.24 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Leg fat-free mass (right) 5.17 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Ever had bowel cancer screening 1.73 1 0 0.0 0.00 1.000 CPED1
Whole body water mass 5.34 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Leg predicted mass (right) 5.31 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Arm fat mass (left) 0.95 1 0 0.0 0.00 1.000 PPP6R3
Average weekly champagne plus white wine intake 2.26 1 0 0.0 0.00 1.000 GAL
High cholesterol (Self-reported) 1.37 1 0 0.0 0.00 1.000 CPED1
Basal metabolic rate 4.76 3 2 4.4 0.00 1.000 CPED1 GAL PPP6R3
Arm fat-free mass (left) 4.37 2 2 4.4 0.00 1.000 GAL PPP6R3
Risk taking 2.95 1 0 0.0 0.00 1.000 ESPL1
Fractured/broken bones in last 5 years 22.49 2 1 2.2 0.00 1.000 CPED1 GREM2
Medication: Omeprazole (e.g. Zanprol) 2.08 1 0 0.0 0.00 1.000 CPED1
Supplements: Calcium 4.92 3 0 0.0 0.00 1.000 CPED1 ESPL1 SPP1
Basal cell carcinoma (self-reported) 5.23 2 0 0.0 0.00 1.000 ESPL1 PPP6R3
Alcohol drinker status: Previous 1.47 1 0 0.0 0.00 1.000 GREM2
Impedance of whole body 2.83 3 1 2.2 0.00 1.000 CPED1 GAL PPP6R3
Arm predicted mass (left) 4.45 2 2 4.4 0.00 1.000 GAL PPP6R3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 1 0.027 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 1 0.023 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3