Hub : Traits :

Medication: Lansoprazole

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 97816039 99315838 1 1 2.9e-07 2.6e-08 0.03 85 DCBLD2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Fasting Glucose 5.53 1 0 0 0 1 DCBLD2
Heel T-Score 1.21 1 0 0 0 1 DCBLD2
Height 1.45 1 1 3 0 1 DCBLD2
Systolic Blood Pressure 2.14 1 0 0 0 1 DCBLD2
Allergy or Eczema 2.58 1 0 0 0 1 DCBLD2
Lung FVC 3.31 1 0 0 0 1 DCBLD2
Tanning 0.98 1 0 0 0 1 DCBLD2
Hand grip strength (left) 2.14 1 0 0 0 1 DCBLD2
Hearing difficulty/problems: Yes 2.59 1 0 0 0 1 DCBLD2
Systolic blood pressure, automated reading 2.03 1 0 0 0 1 DCBLD2
Impedance of leg (right) 0.83 1 0 0 0 1 DCBLD2
Leg fat-free mass (left) 1.07 1 0 0 0 1 DCBLD2
Trunk fat percentage 0.98 1 0 0 0 1 DCBLD2
Hand grip strength (right) 1.91 1 0 0 0 1 DCBLD2
Taking other prescription medications 3.34 1 0 0 0 1 DCBLD2
Hayfever, allergic rhinitis or eczema 3.30 1 0 0 0 1 DCBLD2
Sitting height 1.27 1 0 0 0 1 DCBLD2
High blood pressure (mother) 3.18 1 0 0 0 1 DCBLD2
Leg predicted mass (left) 1.14 1 0 0 0 1 DCBLD2
Allergy 4.15 1 0 0 0 1 DCBLD2
Impedance of arm (right) 6.37 1 1 3 0 1 DCBLD2
Arm fat percentage (right) 1.13 1 0 0 0 1 DCBLD2
Trunk fat-free mass 4.33 1 0 0 0 1 DCBLD2
Asthma 2.78 1 0 0 0 1 DCBLD2
Impedance of arm (left) 5.18 1 0 0 0 1 DCBLD2
Trunk predicted mass 4.38 1 0 0 0 1 DCBLD2
Standing height 2.07 1 0 0 0 1 DCBLD2
Exposure to tobacco smoke at home 4.35 1 0 0 0 1 DCBLD2
Birth weight of first child 3.31 1 0 0 0 1 DCBLD2
Arm fat-free mass (right) 5.19 1 1 3 0 1 DCBLD2
Wheeze or whistling in the chest in last year 3.22 1 0 0 0 1 DCBLD2
Arm predicted mass (right) 5.18 1 1 3 0 1 DCBLD2
Comparative height size at age 10 5.25 1 1 3 0 1 DCBLD2
Suffer from 'nerves' 2.64 1 0 0 0 1 DCBLD2
Overall health rating 2.50 1 0 0 0 1 DCBLD2
Chest pain or discomfort 2.68 1 0 0 0 1 DCBLD2
Whole body fat-free mass 3.07 1 0 0 0 1 DCBLD2
Leg fat-free mass (right) 1.40 1 0 0 0 1 DCBLD2
Long-standing illness, disability or infirmity 4.77 1 0 0 0 1 DCBLD2
Asthma (self-reported) 2.13 1 0 0 0 1 DCBLD2
Osteoporosis (self-reported) 9.52 1 0 0 0 1 DCBLD2
Whole body water mass 3.22 1 0 0 0 1 DCBLD2
Leg predicted mass (right) 1.38 1 0 0 0 1 DCBLD2
Medication: Bendroflumethiazide 3.28 1 0 0 0 1 DCBLD2
Basal metabolic rate 2.24 1 0 0 0 1 DCBLD2
Arm fat-free mass (left) 4.47 1 0 0 0 1 DCBLD2
Risk taking 2.73 1 0 0 0 1 DCBLD2
Unable to work because of sickness or disability 3.92 1 0 0 0 1 DCBLD2
Myopia 3.78 1 0 0 0 1 DCBLD2
Deep venous thrombosis (DVT) (self-reported) 3.13 1 0 0 0 1 DCBLD2
Impedance of whole body 2.64 1 0 0 0 1 DCBLD2
Arm predicted mass (left) 3.85 1 0 0 0 1 DCBLD2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.14
GTEx Adipose Visceral Omentum 0 0.000 1.18
GTEx Adrenal Gland 0 0.000 1.10
GTEx Artery Aorta 0 0.000 1.11
GTEx Artery Coronary 0 0.000 1.18
GTEx Artery Tibial 0 0.000 1.15
GTEx Brain Caudate basal ganglia 0 0.000 1.10
GTEx Brain Cerebellar Hemisphere 0 0.000 1.16
GTEx Brain Cerebellum 0 0.000 1.21
GTEx Brain Cortex 0 0.000 1.16
GTEx Brain Frontal Cortex BA9 1 0.108 1.22
GTEx Brain Hippocampus 0 0.000 1.16
GTEx Brain Hypothalamus 0 0.000 1.16
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.12
GTEx Brain Putamen basal ganglia 0 0.000 1.19
GTEx Breast Mammary Tissue 0 0.000 1.17
GTEx Breast Mammary Tissue (Male) 0 0.000 1.18
GTEx Breast Mammary Tissue (Female) 0 0.000 1.16
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.15
GTEx Cells Transformed fibroblasts 0 0.000 1.18
GTEx Colon Sigmoid 0 0.000 1.22
GTEx Colon Transverse 0 0.000 1.21
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.16
GTEx Esophagus Mucosa 0 0.000 1.21
GTEx Esophagus Muscularis 0 0.000 1.16
GTEx Heart Atrial Appendage 0 0.000 1.16
GTEx Heart Left Ventricle 0 0.000 1.17
GTEx Liver 0 0.000 1.29
GTEx Lung 0 0.000 1.16
GTEx Muscle Skeletal 0 0.000 1.23
GTEx Nerve Tibial 0 0.000 1.16
GTEx Ovary 0 0.000 1.16
GTEx Pancreas 0 0.000 1.22
GTEx Pituitary 0 0.000 1.12
GTEx Prostate 0 0.000 1.10
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.22
GTEx Skin Sun Exposed Lower leg 0 0.000 1.18
GTEx Small Intestine Terminal Ileum 0 0.000 1.16
GTEx Spleen 0 0.000 1.17
GTEx Stomach 0 0.000 1.21
GTEx Testis 0 0.000 1.15
GTEx Thyroid 0 0.000 1.19
GTEx Uterus 0 0.000 1.19
GTEx Vagina 0 0.000 1.11
GTEx Whole Blood 0 0.000 1.18
METSIM Adipose 0 0.000 1.11
NTR Blood 0 0.000 1.13
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.13
YFS Blood 0 0.000 1.09
CommonMind Brain Pre-frontal Cortex 0 0.000 1.14
TCGA Breast Tumor 0 0.000 1.04
TCGA Breast Normal 0 0.000 1.11
TCGA Ovarian Tumor 0 0.000 1.15
TCGA Prostate Tumor 0 0.000 1.12