Hub : Genes

S100A13

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3810 0.0490 0.0e+00 0.387 0.356 0.404 0.387 0.415 5.5e-50 3.3e-45 9.4e-53 6.1e-50 1.4e-54
2 GTEx Adipose Subcutaneous 0.2970 0.0620 2.5e-12 0.213 NA 0.205 NA 0.208 2.8e-17 NA 1.2e-16 NA 6.6e-17
3 GTEx Artery Aorta 0.1080 0.0460 3.2e-03 0.070 NA 0.051 NA 0.039 1.0e-04 NA 8.8e-04 NA 3.4e-03
4 GTEx Artery Tibial 0.1414 0.0449 2.4e-06 0.045 NA 0.077 NA 0.077 1.9e-04 NA 1.2e-06 NA 1.2e-06
5 GTEx Brain Caudate basal ganglia 0.1430 0.0590 3.0e-03 0.077 NA 0.004 NA 0.019 3.2e-03 NA 2.5e-01 NA 9.2e-02
6 GTEx Brain Cortex 0.3680 0.0840 6.2e-07 0.262 NA 0.304 NA 0.336 6.9e-08 NA 4.2e-09 NA 4.6e-10
7 GTEx Brain Frontal Cortex BA9 0.2130 0.0764 7.5e-04 0.038 NA 0.123 NA 0.102 3.5e-02 NA 3.9e-04 NA 1.2e-03
8 GTEx Brain Hippocampus 0.1713 0.0797 9.9e-03 0.015 NA 0.002 NA 0.023 1.4e-01 NA 2.8e-01 NA 9.6e-02
9 GTEx Brain Putamen basal ganglia 0.3820 0.1150 5.9e-05 0.195 NA 0.109 NA 0.084 2.2e-05 NA 1.5e-03 NA 4.9e-03
10 GTEx Cells EBV-transformed lymphocytes 0.1920 0.0680 6.6e-04 0.190 NA 0.140 NA 0.194 8.5e-07 NA 2.7e-05 NA 6.2e-07
11 GTEx Cells Transformed fibroblasts 0.0910 0.0350 5.9e-04 0.109 NA 0.088 NA 0.089 1.5e-08 NA 3.8e-07 NA 3.3e-07
12 GTEx Colon Sigmoid 0.3880 0.0830 1.2e-07 0.248 NA 0.298 NA 0.244 2.8e-09 NA 4.0e-11 NA 4.0e-09
13 GTEx Liver 0.2280 0.0970 2.2e-03 0.058 NA 0.053 NA 0.021 1.1e-02 NA 1.3e-02 NA 8.6e-02
14 GTEx Nerve Tibial 0.1510 0.0438 1.7e-05 0.110 NA 0.105 NA 0.100 3.6e-08 NA 7.6e-08 NA 1.5e-07
15 GTEx Skin Not Sun Exposed Suprapubic 0.2310 0.0650 2.8e-05 0.141 NA 0.120 NA 0.137 3.9e-08 NA 4.1e-07 NA 6.3e-08
16 GTEx Skin Sun Exposed Lower leg 0.0780 0.0340 1.2e-03 0.062 NA 0.039 NA 0.051 7.0e-06 NA 3.1e-04 NA 4.6e-05
17 METSIM Adipose 0.0584 0.0209 4.0e-06 0.062 0.013 0.061 0.004 0.014 1.1e-09 3.9e-03 1.9e-09 6.9e-02 3.2e-03
18 TCGA Breast Invasive Carcinoma 0.0193 0.0140 4.8e-04 0.011 0.009 0.007 NA 0.008 1.6e-03 4.9e-03 1.0e-02 NA 6.4e-03
19 TCGA Colon Adenocarcinoma 0.0500 0.0310 4.5e-04 0.054 0.046 0.037 NA 0.032 4.6e-04 1.1e-03 3.1e-03 NA 6.0e-03
20 TCGA Glioblastoma Multiforme 0.0900 0.0590 4.0e-03 0.046 0.033 0.019 NA 0.017 1.6e-02 3.6e-02 8.7e-02 NA 9.5e-02
21 TCGA Brain Lower Grade Glioma 0.0789 0.0394 4.1e-10 0.086 0.087 0.094 NA 0.089 5.1e-10 4.4e-10 7.5e-11 NA 2.8e-10
22 TCGA Lung Adenocarcinoma 0.0312 0.0192 6.5e-05 0.043 0.032 0.031 NA 0.037 7.3e-06 1.0e-04 1.4e-04 NA 3.5e-05
23 TCGA Pancreatic Adenocarcinoma 0.0610 0.0390 6.2e-04 0.075 0.084 0.062 NA 0.019 4.8e-04 2.2e-04 1.4e-03 NA 5.3e-02
24 TCGA Stomach Adenocarcinoma 0.0270 0.0200 5.1e-03 0.014 0.028 0.014 NA 0.020 3.0e-02 3.8e-03 3.0e-02 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bipolar Disorder (2018) 0.7 1.0 2.8 0.8 -1.2 -0.3 -0.3 0.8 1.0 -0.5 0.9 -1.0 -0.9 0.8 -0.4 1.6 -1.7 -1.2 -1.2 -1.2 0.9 1.1 1.2 0.9 1.1 0.9 1.1
Bipolar Disorder or Schizophrenia 1.2 2.8 14.7 1.5 -1.7 0.6 -1.6 1.5 1.2 -0.0 1.5 -1.6 -1.5 1.5 -0.7 3.8 -2.3 -1.6 -1.7 -1.7 1.4 1.6 1.7 1.5 1.6 1.5 1.7
Depressed Affect (Nagel 2018) 0.6 1.3 4.5 -1.2 1.1 -0.3 0.7 -0.9 -1.5 -1.1 -1.0 2.1 1.1 -0.8 0.2 -0.8 0.8 1.0 1.1 1.1 -1.3 -1.1 -1.2 -1.4 -1.1 -1.2 -1.2
Depression (Nagel 2018) 0.2 0.2 0.9 0.0 -0.4 0.7 -0.6 0.8 -0.1 -0.7 -0.2 0.3 -0.5 0.7 0.8 1.0 -0.6 -0.4 -0.3 -0.3 -0.2 0.2 0.2 -0.0 0.3 0.2 0.2
Intelligence (Savage-Jansen 2018) 0.4 1.1 7.2 -0.5 0.3 -1.6 2.7 -1.0 -0.5 -1.2 -0.2 -2.5 0.5 -0.7 0.9 -1.7 0.7 0.1 0.3 0.5 -0.7 -0.3 -0.3 -0.6 -0.3 -0.6 -0.4
Neuroticism (Nagel 2018) 0.4 1.0 5.7 0.5 -1.0 1.4 -1.5 1.1 0.3 0.4 0.5 2.4 -0.8 1.0 -1.0 1.4 -1.5 -0.7 -0.9 -0.8 0.3 0.8 0.7 0.3 1.0 0.6 0.7
Schizophrenia (2018) 0.9 1.8 12.6 1.3 -1.2 0.1 -1.8 1.3 0.8 0.4 1.2 -1.0 -1.3 1.3 -0.8 3.5 -1.5 -1.1 -1.2 -1.3 1.1 1.2 1.2 1.2 1.1 1.2 1.3
Schizophrenia vs Biploar Disorder 0.6 0.8 1.4 -0.9 1.1 -0.9 -0.3 -1.0 -1.2 -0.7 -0.8 0.1 1.1 -1.0 0.2 0.4 0.6 1.0 1.1 1.0 -0.9 -1.1 -1.1 -1.0 -1.1 -1.0 -1.1
Worry (Nagel 2018) 4.6 9.7 18.2 2.7 -3.5 3.1 -4.3 3.6 2.7 2.4 2.5 2.6 -3.2 3.1 -2.4 2.9 -4.0 -3.3 -3.4 -3.2 2.5 3.3 3.2 2.6 3.4 3.0 3.2
Alzheimer’s Disease (in mother) 1.3 1.5 3.0 1.3 -1.0 1.3 -1.6 0.7 1.5 1.0 1.5 1.1 -1.0 1.1 -1.7 1.1 -1.0 -0.8 -1.1 -1.2 1.3 1.2 1.1 1.3 1.1 1.4 1.2
Alzheimer’s Disease (in father) 0.7 0.8 3.1 0.5 -1.0 0.0 -1.7 0.7 0.8 1.8 0.3 -0.6 -1.1 0.9 0.9 0.5 -0.9 -1.1 -1.0 -0.8 0.3 1.0 1.0 0.4 0.9 0.6 0.8
Alzheimer’s Disease (including proxy) 1.2 1.7 4.4 1.4 -1.2 1.1 -2.1 0.6 1.5 1.8 1.4 0.7 -1.4 1.6 -1.3 1.1 -1.2 -1.0 -1.2 -1.3 1.1 1.4 1.4 1.2 1.2 1.4 1.3
Crohns Disease (2017) 0.5 1.0 7.9 -0.4 1.1 -1.4 1.8 -1.2 -0.2 -0.1 -0.5 -0.5 0.5 -0.1 0.7 -2.8 0.9 1.0 1.1 0.7 -0.5 -0.7 -0.8 -0.5 -1.1 -0.4 -0.7
Irritable Bowel Disease (IBD) 0.1 0.2 1.6 0.2 0.5 -0.2 0.8 0.0 0.3 0.4 -0.1 0.8 -0.1 0.4 -0.3 -1.3 0.6 0.4 0.4 0.0 0.3 -0.1 -0.1 0.3 -0.4 0.2 0.0
Ulcerative Colitis (UC) 0.9 1.6 3.5 1.2 -1.0 1.5 -1.2 1.9 1.3 1.1 1.0 1.7 -1.2 1.3 -1.5 1.4 -0.4 -0.9 -1.0 -1.3 1.5 1.2 1.2 1.6 1.0 1.3 1.4
Major Depression (MDD) 1.7 2.0 6.1 1.5 -1.0 2.4 -2.5 1.7 1.6 0.3 1.3 0.5 -1.3 1.6 -0.6 1.9 -0.0 -1.2 -1.0 -1.4 1.6 1.3 1.2 1.6 1.0 1.5 1.4
Reaction Time 0.1 0.2 1.1 0.2 0.5 0.1 1.0 -0.6 -0.1 -0.4 0.3 -0.8 -0.0 0.3 0.8 0.3 1.1 0.5 0.5 0.3 -0.1 -0.3 -0.3 -0.2 -0.5 -0.1 -0.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.2 0.6 -1.3 1.3 0.7 0.9 1.1 0.0 0.5 -0.4 -0.9 0.5 0.3 -1.3 -0.7 -1.5 -1.3 -1.0 0.6 1.2 1.1 0.8 1.3 0.8 1.1
Breast Cancer 0.1 0.2 1.6 0.1 -0.5 -0.6 -0.1 0.0 0.2 0.6 -0.1 -0.6 -0.3 0.1 0.3 -1.2 -0.2 -0.5 -0.5 -0.3 0.2 0.3 0.3 0.3 0.5 0.4 0.4
Ovarian Cancer 2.2 2.9 7.0 1.6 -2.0 1.4 -1.8 2.2 1.4 2.6 1.6 0.6 -1.8 1.7 -0.8 1.5 -1.7 -1.9 -2.0 -1.9 1.2 1.8 1.8 1.4 1.9 1.6 1.7
Prostate Cancer 1.3 1.8 4.7 -1.4 1.3 0.1 -1.7 -0.8 -1.4 -0.3 -1.8 -1.3 1.1 -0.5 2.2 0.8 1.4 1.3 1.3 1.4 -1.8 -1.4 -1.4 -1.6 -1.2 -1.3 -1.5
Age at First Birth 5.1 7.5 25.3 -3.4 2.8 -2.8 5.0 -3.3 -3.6 -3.3 -3.3 -2.7 3.2 -3.5 3.1 -3.6 2.0 2.7 2.7 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Bipolar Disorder (2011) 0.8 0.8 2.2 1.3 -1.1 0.9 -0.8 0.6 1.3 0.2 1.3 0.0 -1.3 1.5 -1.0 0.7 -1.5 -1.0 -1.0 -1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 -1.2 0.4 -0.4 -0.2 -0.7 -1.0 -0.3 -1.3 -0.5 0.5 -0.7 0.8 1.1 -0.9 0.5 0.4 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Coronary Artery Disease (CAD) 1.7 2.0 5.3 1.9 -1.6 2.3 -1.7 1.5 1.8 2.1 1.7 1.1 -1.9 1.9 -0.9 -0.6 -1.8 -1.5 -1.6 -1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.5 3.6 -0.6 0.1 -0.4 0.4 -0.6 -0.4 0.2 -0.7 -1.9 0.1 -0.3 1.6 -1.1 -0.5 -0.0 0.1 0.3 -0.8 -0.1 -0.2 -0.8 -0.1 -0.5 -0.4
Mean Putamen Volume 0.2 0.3 1.9 -0.2 -0.3 -0.1 1.2 -0.0 -0.1 0.4 -0.2 0.5 -0.1 0.4 0.8 -1.4 -1.0 -0.3 -0.2 0.1 -0.4 0.1 0.1 -0.5 0.2 -0.2 -0.1
Fasting Glucose 1.2 1.4 4.6 0.8 -1.3 1.9 -2.1 2.0 1.6 0.8 1.3 -0.9 -1.4 1.3 -0.3 1.7 -1.2 -1.6 -1.5 -1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0
HbA1C 0.5 0.6 2.1 0.7 -0.7 0.5 -0.4 0.4 1.3 0.7 1.0 1.3 -0.9 0.9 -1.4 -0.5 0.3 -1.1 -0.9 -0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0
HDL Cholesterol 3.3 5.5 15.1 -3.1 2.7 -3.9 3.2 -3.4 -3.2 -1.6 -3.1 -0.3 2.9 -3.0 1.9 -3.0 2.1 2.5 2.6 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
LDL Cholesterol 1.8 2.9 8.2 2.7 -2.0 1.4 -2.4 2.0 2.8 1.1 2.9 0.2 -2.1 2.2 -1.3 1.4 -1.5 -2.0 -2.0 -2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Lupus 0.2 0.3 3.8 -0.4 0.4 -0.2 1.1 -1.0 -0.3 0.1 -0.4 0.6 0.3 -0.2 -0.2 -1.9 0.2 0.4 0.3 0.3 -0.2 -0.3 -0.3 -0.1 -0.4 -0.2 -0.2
Neuroticism (2016) 1.2 1.8 3.5 -1.4 1.5 -0.6 0.8 -0.9 -1.3 -1.9 -1.7 0.8 1.3 -1.2 0.6 1.0 1.6 1.5 1.6 1.6 -1.0 -1.5 -1.5 -1.4 -1.6 -1.4 -1.5
Primary Biliary Cirrhosis 0.4 0.6 1.5 0.9 -0.8 0.6 -0.1 0.1 0.8 0.4 0.9 -0.6 -0.9 0.8 -0.4 -1.2 -0.7 -0.9 -0.9 -0.8 0.8 0.8 0.9 0.8 0.8 0.8 0.8
Rheumatoid Arthritis 1.3 1.8 3.0 -1.0 1.5 -1.4 1.7 -0.9 -1.0 -1.6 -0.7 -1.0 1.6 -1.6 1.1 -1.5 1.6 1.5 1.5 1.4 -0.8 -1.4 -1.5 -0.9 -1.5 -1.1 -1.3
Schizophrenia (2014) 0.5 1.0 9.3 0.5 -0.8 0.1 -1.6 0.8 0.2 -0.9 0.5 -1.5 -0.7 0.6 0.1 3.1 -1.4 -0.7 -0.8 -0.8 0.5 0.7 0.7 0.6 0.7 0.6 0.7
Triglycerides 1.4 2.2 7.8 2.3 -1.2 2.1 -2.3 2.0 2.3 1.4 2.4 -0.6 -1.5 1.7 -1.2 2.8 0.3 -1.0 -1.1 -1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 4.5 5.2 11.6 3.2 -2.8 1.7 -1.9 2.8 3.4 2.0 3.3 2.2 -3.1 3.1 -2.9 0.3 -2.0 -3.3 -3.1 -3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.4 0.6 1.6 0.8 -0.7 1.3 -1.0 0.9 0.9 0.4 0.7 0.6 -0.7 0.6 -0.8 1.0 -0.3 -0.6 -0.7 -0.9 1.0 0.8 0.7 0.9 0.7 0.9 0.8
Blood Eosinophil Count 0.2 1.6 7.3 0.2 -1.6 1.2 -1.3 1.2 0.3 1.6 0.1 0.3 -0.8 0.4 -0.7 2.0 -2.7 -1.8 -1.6 -1.5 0.4 1.3 1.2 0.5 1.6 0.7 1.0
Blood Platelet Count 3.5 41.0 82.3 6.5 -6.5 5.7 -9.1 6.7 6.4 6.0 6.0 2.4 -6.8 7.0 -5.6 5.1 -6.0 -6.4 -6.4 -6.7 6.2 6.6 6.6 6.7 6.5 6.9 6.8
Blood Red Count 0.1 0.9 2.2 -0.4 1.4 -1.4 1.3 -0.9 -0.4 1.5 -0.6 -0.4 0.7 -0.1 0.6 0.4 0.9 1.4 1.4 0.9 -0.4 -1.0 -1.0 -0.6 -1.4 -0.6 -1.0
Blood White Count 1.1 7.9 14.0 2.3 -3.3 1.7 -3.6 3.3 2.2 2.0 2.5 1.6 -2.6 2.0 -3.3 1.7 -3.7 -3.4 -3.3 -3.1 2.6 3.1 2.9 2.6 3.2 2.7 3.0
Heel T-Score 0.2 1.3 2.7 1.0 -1.3 1.4 -0.4 0.9 1.0 0.9 0.9 1.2 -1.3 1.6 -1.4 -0.6 -0.9 -1.2 -1.3 -1.3 0.7 1.2 1.3 0.9 1.3 1.1 1.2
BMI 0.1 0.4 3.3 -0.3 0.3 -0.3 0.9 -0.6 -0.7 -0.5 -0.1 1.1 0.4 -0.3 -0.4 -1.8 0.7 0.2 0.4 0.4 -0.9 -0.4 -0.3 -0.7 -0.3 -0.6 -0.4
Height 1.3 24.2 36.6 4.9 -5.0 4.3 -5.4 5.9 5.1 5.2 4.6 2.8 -5.2 5.0 -4.4 6.0 -4.0 -5.0 -5.0 -4.9 4.6 5.1 5.2 4.6 5.0 4.9 5.1
Waist Hip Ratio (WHR) 0.8 3.8 5.3 -2.0 2.0 -1.8 2.3 -2.2 -1.9 -0.1 -1.8 -1.3 1.9 -2.0 1.5 -2.0 2.1 1.9 1.9 2.1 -2.1 -1.9 -2.0 -2.3 -2.0 -2.1 -2.1
Systolic Blood Pressure 0.1 0.5 2.3 0.5 -0.5 0.4 1.5 -0.6 0.5 0.9 0.7 0.7 -0.6 0.8 -1.5 -0.9 -1.1 -0.3 -0.5 -0.5 0.3 0.5 0.5 0.3 0.5 0.6 0.4
Smoking Status 0.2 0.6 1.8 -0.6 0.8 -1.3 -0.4 -0.8 -0.4 -0.9 -0.4 -0.8 0.7 -0.6 1.0 1.3 0.2 0.6 0.7 0.7 -0.4 -0.7 -0.7 -0.6 -0.8 -0.6 -0.7
Allergy or Eczema 2.8 7.5 15.9 2.3 -3.4 0.9 -4.0 3.2 2.0 2.9 2.0 -0.1 -2.8 1.9 -1.4 2.9 -3.1 -3.5 -3.3 -3.2 2.0 3.0 3.0 2.5 3.3 2.6 2.8
Cardiovascular Disease 0.2 0.6 2.0 0.8 -0.6 0.4 1.3 -0.1 0.6 1.0 1.0 1.0 -0.6 0.7 -1.1 -1.4 0.2 -0.8 -0.6 -0.5 1.0 0.5 0.6 0.6 0.6 0.7 0.6
Hypothyroidism (self reported) 0.1 0.1 0.4 -0.5 0.1 0.6 0.6 -0.4 -0.4 -0.7 -0.7 0.1 0.0 0.1 -0.2 0.1 -0.4 -0.0 0.1 0.2 -0.4 -0.2 -0.1 -0.5 -0.1 -0.3 -0.3
Respiratory disease 1.3 2.9 11.4 1.6 -1.6 -0.6 -2.6 1.3 1.3 0.8 1.7 2.3 -1.4 1.0 -3.4 1.7 -1.4 -1.5 -1.6 -1.9 1.6 1.6 1.6 1.8 1.6 1.7 1.6
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.4 -1.4 1.1 -0.7 1.1 -1.1 -1.2 -1.1 -1.2 -1.5 1.3 -1.4 1.5 -1.2 0.4 1.0 1.0 1.2 -1.0 -1.0 -1.2 -1.2 -1.0 -1.2 -1.1
Lung FEV1/FVC ratio 0.1 0.3 2.6 -0.3 -0.7 1.6 -0.3 0.8 -0.0 0.4 -0.6 -0.1 -0.3 0.4 0.8 -0.1 -0.4 -0.8 -0.6 -0.3 -0.0 0.4 0.4 -0.1 0.6 0.1 0.3
Lung FVC 1.6 8.3 14.9 3.8 -2.8 2.4 -1.0 3.4 3.3 1.9 3.9 0.5 -3.1 3.2 -2.1 1.5 -2.1 -2.7 -2.7 -3.0 3.5 3.0 3.0 3.6 2.8 3.5 3.2
Neuroticism 0.3 0.7 8.1 0.8 -0.5 0.7 -1.1 0.6 0.4 0.4 1.0 2.8 -0.6 0.8 -0.8 -0.1 -0.6 -0.4 -0.4 -0.4 0.6 0.5 0.5 0.5 0.5 0.6 0.5
Chronotype (morning person) 0.1 0.2 2.2 -0.2 -0.0 0.1 -0.9 0.4 -0.4 0.5 -0.2 0.1 0.0 0.1 0.6 1.5 0.2 -0.1 -0.1 0.0 -0.1 -0.0 -0.1 -0.2 0.1 -0.0 -0.1
Hair Pigment 0.1 1.5 5.4 1.5 0.6 1.6 -0.2 0.3 1.7 -0.5 1.6 1.5 -0.5 1.0 -1.5 -2.3 2.3 0.2 0.6 -0.2 2.0 0.2 0.2 1.7 -0.5 1.1 0.6
Tanning 0.1 1.3 4.3 0.6 -1.5 1.4 -2.1 1.5 0.7 0.6 0.7 -0.1 -1.0 0.7 -0.6 1.1 -1.3 -1.5 -1.4 -1.1 0.3 1.2 1.2 0.6 1.5 0.7 1.1
Hand grip strength (left) 0.1 0.2 1.1 -0.0 0.6 -0.5 -0.5 -0.3 0.1 0.7 -0.2 -0.9 0.1 0.2 1.1 0.8 0.3 0.6 0.6 0.4 -0.2 -0.4 -0.3 -0.2 -0.6 -0.2 -0.4
Number of treatments/medications taken 1.7 3.0 6.2 1.9 -1.8 1.8 -1.4 1.6 1.5 2.5 1.8 0.7 -2.1 2.2 -1.3 0.7 -1.6 -1.8 -1.8 -1.6 1.5 1.8 1.9 1.5 1.8 1.8 1.8
Average weekly spirits intake 0.1 0.2 1.1 -0.2 -0.3 0.2 0.3 0.1 -0.5 0.4 -0.4 0.3 -0.2 -0.0 0.3 -0.9 -1.0 -0.3 -0.3 -0.1 -0.8 0.2 0.1 -0.5 0.3 -0.1 -0.1
Sensitivity / hurt feelings 0.6 1.1 3.5 -1.1 0.8 -1.0 0.1 -1.1 -1.6 -1.9 -1.0 0.9 1.1 -0.8 0.9 -0.3 0.1 0.9 0.9 1.0 -1.4 -1.0 -0.9 -1.2 -0.8 -1.3 -1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 2.5 0.0 0.5 0.6 -0.6 0.2 -0.4 -0.2 -0.4 0.7 0.1 0.4 0.1 1.6 0.3 0.6 0.6 0.3 -0.1 -0.5 -0.4 0.0 -0.6 -0.2 -0.3
Hearing difficulty/problems: Yes 0.3 0.5 4.5 0.8 -0.3 0.9 -0.6 0.6 0.7 1.0 0.7 0.1 -0.6 0.8 -0.1 2.1 -0.2 -0.2 -0.3 -0.4 0.8 0.4 0.5 0.7 0.4 0.6 0.6
Relative age of first facial hair 0.2 0.3 2.0 0.4 -0.4 0.0 0.9 -0.0 0.7 1.4 0.1 -0.0 -0.6 0.6 0.5 -1.0 -0.3 -0.5 -0.4 -0.5 0.7 0.4 0.5 0.4 0.4 0.5 0.5
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 3.3 0.9 -1.4 1.2 -1.7 1.6 0.9 1.5 1.1 0.1 -1.1 0.8 -1.0 1.8 -1.3 -1.3 -1.4 -1.2 1.3 1.3 1.1 1.0 1.4 1.2 1.2
Ever used hormone-replacement therapy (HRT) 0.1 0.2 1.0 -0.3 -0.3 0.4 0.4 -0.1 -0.4 0.4 -0.3 -0.8 -0.2 0.3 0.9 0.0 -1.0 -0.3 -0.3 -0.0 -0.6 0.1 0.1 -0.5 0.3 -0.2 0.0
Ever had hysterectomy (womb removed) 2.8 3.2 4.9 -1.8 2.1 -1.6 1.6 -2.2 -1.8 -0.4 -1.7 -0.3 2.0 -2.0 0.7 -0.2 2.1 2.1 2.1 2.1 -1.4 -2.1 -2.2 -1.7 -2.1 -1.9 -2.0
Systolic blood pressure, automated reading 0.1 0.2 1.3 -0.1 0.1 0.2 1.0 -0.8 -0.2 0.9 -0.0 1.1 0.1 0.1 -0.9 -0.3 -0.7 0.4 0.1 0.0 -0.3 -0.1 -0.2 -0.2 -0.1 -0.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.9 0.5 -0.4 1.3 -0.8 0.8 0.7 0.1 0.6 -1.4 -0.4 0.3 -0.0 0.7 -0.6 -0.3 -0.4 -0.6 0.9 0.6 0.5 0.8 0.5 0.7 0.6
Angina 0.2 0.3 4.6 -0.3 -0.1 -0.3 0.7 -0.3 0.1 -0.8 -0.2 0.7 0.2 -0.4 0.0 -2.1 -0.1 -0.1 0.0 0.2 0.2 -0.0 -0.1 -0.2 0.0 -0.2 0.0
Medication for hormone replacement therapy 1.1 1.2 5.8 0.9 -1.1 0.9 -1.5 1.4 0.9 1.2 0.7 0.1 -1.2 0.9 -0.6 2.4 -1.3 -1.0 -1.1 -1.0 0.5 1.0 1.0 0.6 1.1 0.9 0.9
Vitamin and mineral supplements 0.3 0.4 1.4 0.6 -0.4 1.2 -0.6 0.9 0.8 0.3 0.3 -0.4 -0.5 0.5 -0.2 0.2 0.2 -0.4 -0.3 -0.5 1.1 0.6 0.5 1.0 0.4 0.7 0.8
Supplements: Zinc 0.6 0.7 3.8 0.3 -0.7 -0.3 -1.2 0.9 0.2 1.1 0.1 2.0 -0.6 0.4 -1.3 1.5 -1.2 -0.7 -0.7 -0.5 -0.1 0.4 0.6 0.0 0.7 0.3 0.3
Medication: Co-codamol 3.0 3.5 5.2 1.9 -2.0 2.0 -1.6 2.3 1.6 1.1 1.6 0.5 -2.0 2.1 -1.6 2.0 -2.1 -2.0 -2.0 -2.0 1.9 1.9 2.0 1.8 2.0 1.9 1.9
Medication: Metformin 0.6 0.8 2.1 -1.3 0.7 -0.6 1.3 -1.1 -0.7 -0.6 -1.4 -0.2 0.8 -0.8 0.4 -1.5 -0.1 0.8 0.7 1.0 -0.8 -0.7 -0.8 -1.0 -0.8 -1.0 -0.8
Diabetes (father) 1.4 1.7 4.2 1.1 -1.7 1.0 -0.9 2.0 1.4 0.9 0.9 -0.2 -1.3 0.5 0.1 -0.3 -1.2 -1.8 -1.7 -1.6 1.3 1.6 1.5 1.3 1.8 1.4 1.5
Diabetes (mother) 0.8 1.0 3.1 0.7 -1.3 0.2 0.0 0.3 0.5 1.8 0.7 1.3 -1.1 0.9 -1.2 -0.0 -0.8 -1.5 -1.4 -1.0 0.5 1.2 1.3 0.5 1.4 0.7 1.0
Severe depression (siblings) 0.1 0.1 1.0 0.0 0.3 0.3 -0.4 -0.2 -0.1 0.3 -0.0 -0.2 0.2 0.2 0.5 1.0 -0.0 0.4 0.3 0.3 -0.2 -0.3 -0.3 -0.3 -0.2 -0.1 -0.3
Pack years adult smoking proportion 3.6 5.5 10.3 -1.8 3.1 -2.2 2.5 -3.0 -2.3 -0.8 -1.7 -0.7 2.4 -1.6 1.0 -0.5 2.0 3.2 3.1 2.9 -1.9 -2.8 -2.8 -2.2 -3.1 -2.3 -2.7
Impedance of leg (right) 1.3 6.4 13.0 2.2 -2.5 1.6 -3.3 2.4 3.0 3.6 1.9 1.3 -2.5 2.2 -2.3 3.2 -1.7 -2.4 -2.5 -2.6 2.8 2.6 2.5 2.7 2.4 2.6 2.6
Leg fat-free mass (left) 0.0 0.1 0.7 0.0 0.2 0.0 0.3 0.1 -0.5 -0.8 0.1 -0.2 0.1 0.1 0.1 -0.6 0.7 0.0 0.2 0.2 -0.4 -0.2 -0.0 -0.3 -0.1 -0.3 -0.1
Trunk fat percentage 0.5 1.9 4.7 1.0 -1.8 0.7 -2.2 2.0 0.8 1.0 0.9 0.8 -1.4 1.1 -1.0 0.9 -1.0 -1.9 -1.8 -1.5 0.6 1.6 1.6 1.0 1.9 1.1 1.5
Hand grip strength (right) 0.1 0.3 1.6 0.2 0.8 -0.3 0.3 -0.7 0.2 1.3 0.0 0.2 0.2 0.3 0.3 0.6 0.5 0.9 0.8 0.5 -0.0 -0.5 -0.4 -0.1 -0.8 -0.1 -0.4
Townsend deprivation index at recruitment 0.2 0.3 2.1 -0.2 -0.2 -0.4 -0.5 0.3 -0.4 -0.8 -0.2 1.3 -0.1 -0.3 -0.6 -1.5 -0.0 -0.3 -0.3 -0.2 -0.4 0.2 0.2 -0.2 0.3 -0.2 0.0
Current tobacco smoking 1.0 1.6 4.0 -1.3 1.2 -2.0 0.9 -1.3 -1.3 -1.4 -1.0 -0.8 1.5 -1.5 0.7 -0.5 0.5 1.1 1.2 1.5 -1.4 -1.4 -1.4 -1.4 -1.3 -1.4 -1.4
Average weekly fortified wine intake 0.3 0.3 1.6 0.1 -0.7 1.3 -1.2 0.7 0.1 0.1 -0.1 -0.3 -0.4 0.2 -0.6 0.7 -0.7 -0.5 -0.7 -0.7 0.3 0.6 0.5 0.4 0.7 0.3 0.5
Maternal smoking around birth 4.3 6.2 8.5 2.5 -2.7 2.9 -2.5 2.9 2.6 2.2 2.4 0.4 -2.6 2.3 -1.0 0.9 -1.7 -2.8 -2.7 -2.9 2.8 2.8 2.7 2.9 2.8 2.8 2.9
Fed-up feelings 1.2 2.1 3.6 -1.1 1.9 -0.3 1.7 -1.5 -1.3 -1.6 -0.9 0.6 1.5 -1.0 1.0 -0.7 1.9 1.9 1.9 1.8 -1.1 -1.7 -1.7 -1.5 -1.9 -1.4 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 -0.5 0.7 0.6 0.4 -0.4 -0.6 -0.5 -0.8 0.2 0.4 0.0 0.4 0.4 0.5 0.7 0.7 0.5 -0.3 -0.6 -0.6 -0.5 -0.8 -0.5 -0.5
Relative age voice broke 1.2 1.9 7.6 1.7 -1.0 0.9 0.4 0.9 1.8 2.8 1.4 -0.2 -1.4 1.4 -0.6 0.8 -0.8 -0.9 -0.9 -1.4 2.2 1.2 1.2 2.0 0.9 1.7 1.4
Taking other prescription medications 1.4 2.1 3.5 1.5 -1.5 1.0 -1.6 1.5 1.2 1.7 1.3 0.2 -1.6 1.5 -1.4 1.9 -1.8 -1.5 -1.5 -1.4 1.5 1.5 1.5 1.3 1.4 1.5 1.5
Age when periods started (menarche) 1.7 4.0 6.1 1.8 -2.3 1.6 -0.4 2.3 2.0 1.1 1.5 0.6 -2.1 1.5 -1.8 -2.0 -1.5 -2.4 -2.3 -2.4 2.3 2.4 2.3 2.5 2.3 2.2 2.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.8 0.7 -0.4 1.0 -0.8 0.5 0.5 0.8 0.9 -0.5 -0.5 0.6 -0.3 1.4 -0.5 -0.3 -0.4 -0.5 0.5 0.5 0.5 0.4 0.4 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 10.4 1.7 -1.5 1.6 -0.9 1.3 1.8 1.2 1.6 3.2 -1.6 1.6 -2.4 -0.4 -1.2 -1.6 -1.5 -1.6 1.6 1.6 1.6 1.6 1.5 1.7 1.5
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 2.6 0.2 -0.0 0.4 0.6 -0.4 0.4 1.6 -0.1 0.1 -0.2 0.4 -0.8 0.1 -0.2 0.0 -0.0 0.0 0.4 0.1 0.2 0.2 0.0 0.2 0.2
Qualifications: CSEs or equivalent 1.6 2.2 3.1 1.8 -1.3 1.6 -1.3 1.4 1.5 0.7 1.8 0.4 -1.5 1.7 -1.7 1.2 -0.8 -1.2 -1.3 -1.7 1.8 1.5 1.5 1.8 1.4 1.7 1.5
Serious illness, injury or assault to yourself 0.1 0.2 1.1 -0.7 -0.1 -0.0 -0.2 0.4 -0.3 -0.4 -0.8 -0.7 0.2 -0.4 1.1 0.2 0.1 -0.1 -0.1 0.0 -0.2 0.0 -0.1 -0.2 0.2 -0.3 -0.0
High blood pressure 0.2 0.5 4.3 0.5 -0.1 0.1 2.1 -0.4 0.2 0.8 0.5 0.3 -0.3 0.4 -0.8 -1.9 0.4 -0.1 -0.1 -0.2 0.7 0.1 0.2 0.4 0.1 0.4 0.3
Hayfever, allergic rhinitis or eczema 2.5 5.4 12.9 2.2 -2.8 0.6 -3.6 2.8 2.0 2.3 2.2 0.0 -2.3 1.6 -1.0 2.2 -2.5 -2.9 -2.7 -2.7 1.8 2.5 2.5 2.2 2.7 2.3 2.4
Multivitamins +/- minerals 0.3 0.4 3.4 0.6 -0.7 0.0 -0.1 0.5 0.5 0.2 0.6 1.9 -0.8 0.8 -0.2 -0.2 -0.8 -0.6 -0.7 -0.6 0.1 0.5 0.6 0.1 0.7 0.5 0.3
Stomach or abdominal pain in last month 5.8 7.2 12.7 2.9 -2.2 2.6 -2.9 3.0 2.9 3.4 2.8 2.3 -2.5 2.6 -3.6 2.4 -1.4 -2.1 -2.1 -2.5 3.2 2.5 2.4 3.1 2.1 2.9 2.7
Supplements: Glucosamine 0.1 0.1 1.9 0.2 0.1 -0.5 0.2 -0.1 0.0 1.4 0.4 0.2 0.1 -0.1 -0.0 0.7 -0.0 0.2 0.1 0.0 0.0 -0.0 -0.0 -0.1 -0.0 0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 2.6 -0.5 0.7 0.6 -0.5 -0.7 -0.5 1.1 -0.5 -0.1 0.6 -0.2 -0.6 1.6 0.5 0.8 0.7 0.7 -0.3 -0.7 -0.8 -0.3 -0.8 -0.4 -0.6
Medication: Atenolol 0.5 0.6 7.1 0.0 -0.8 0.5 0.6 0.2 0.5 2.7 -0.2 -0.2 -0.5 0.5 -0.0 -0.1 -0.8 -0.7 -0.8 -0.8 0.7 0.7 0.7 0.7 0.8 0.5 0.8
Medication: Levothyroxine sodium 0.1 0.2 1.2 -0.3 0.3 0.0 0.8 -0.5 -0.4 -0.6 -0.4 1.1 0.1 0.1 -0.3 -0.3 0.1 0.3 0.4 0.4 -0.3 -0.3 -0.3 -0.5 -0.3 -0.3 -0.4
Sitting height 0.3 1.9 8.9 1.6 -1.0 0.6 -1.0 1.3 1.8 1.5 1.6 0.5 -1.4 1.4 -1.5 3.0 -1.0 -1.0 -1.0 -1.1 1.7 1.2 1.3 1.4 1.0 1.4 1.3
Chronic bronchitis/emphysema (father) 0.2 0.3 2.3 0.1 -0.4 0.6 0.0 0.6 0.2 0.3 -0.1 -1.5 -0.3 0.4 0.5 1.2 0.2 -0.3 -0.4 -0.5 0.4 0.4 0.3 0.4 0.5 0.4 0.5
High blood pressure (mother) 2.6 3.7 7.0 1.5 -2.6 1.1 -1.6 2.2 1.5 1.7 1.4 -0.3 -2.1 1.5 -0.9 1.4 -2.1 -2.6 -2.6 -2.4 1.7 2.3 2.3 1.6 2.6 1.8 2.1
Body mass index (BMI) 0.3 1.2 3.4 -1.1 0.9 -0.8 1.0 -0.6 -1.6 -1.4 -1.1 0.9 1.0 -1.0 0.4 -1.8 1.2 0.8 0.9 1.1 -1.5 -1.0 -0.9 -1.3 -0.8 -1.2 -1.0
Impedance of leg (left) 2.0 9.8 15.7 2.8 -3.2 2.5 -4.0 3.3 3.7 4.0 2.5 1.6 -3.1 2.8 -2.4 3.7 -2.5 -3.1 -3.2 -3.3 3.3 3.3 3.2 3.2 3.1 3.3 3.3
Leg predicted mass (left) 0.0 0.1 0.7 0.1 0.2 0.1 0.3 0.2 -0.4 -0.8 0.1 -0.2 0.0 0.1 -0.0 -0.5 0.7 0.0 0.1 0.2 -0.3 -0.2 0.0 -0.2 -0.1 -0.2 -0.1
Trunk fat mass 0.2 1.0 2.8 0.7 -1.3 0.6 -1.6 1.7 0.4 0.6 0.7 0.6 -1.0 0.8 -0.7 0.6 -0.5 -1.5 -1.3 -1.1 0.3 1.1 1.2 0.7 1.4 0.8 1.1
Waist circumference 0.3 1.1 2.5 -1.1 0.9 -0.7 0.9 -0.6 -1.5 -0.8 -1.1 0.2 1.0 -1.0 0.4 -1.3 1.4 0.8 0.9 1.1 -1.6 -1.0 -0.9 -1.4 -0.8 -1.3 -1.1
Number of incorrect matches in round 1.1 1.8 3.8 -0.9 1.8 -0.7 0.9 -1.3 -1.1 -1.9 -0.5 0.3 1.5 -1.3 -0.1 -0.4 1.7 1.8 1.9 1.7 -1.1 -1.6 -1.7 -1.1 -1.8 -1.3 -1.5
Past tobacco smoking 0.5 1.0 2.4 1.2 -0.9 1.6 -0.0 0.6 0.9 1.4 1.2 -0.3 -1.0 1.2 -1.1 -0.2 -0.9 -0.7 -0.9 -0.9 0.9 1.0 0.9 1.0 0.9 1.2 1.0
Alcohol usually taken with meals 1.4 2.3 4.3 -1.6 1.5 -1.7 2.1 -1.5 -1.8 -1.6 -1.7 -1.8 1.6 -1.8 0.8 0.0 0.1 1.4 1.5 1.5 -1.4 -1.6 -1.6 -1.3 -1.6 -1.6 -1.6
Nervous feelings 2.1 3.9 11.5 1.6 -2.1 1.7 -3.4 2.6 1.6 1.4 1.4 1.2 -1.8 1.6 -1.3 2.0 -2.7 -2.0 -2.0 -2.0 1.7 2.0 1.9 1.8 2.1 1.9 1.9
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 3.6 1.0 -1.1 1.6 -1.7 1.6 0.7 -0.0 0.8 -0.6 -1.2 1.2 0.5 1.9 -1.1 -1.1 -1.1 -1.0 0.7 1.0 1.0 0.8 1.1 0.9 0.9
Hearing difficulty/problems with background noise 0.4 0.7 2.9 0.7 -0.7 0.3 -1.3 1.0 0.7 1.7 0.5 0.6 -0.8 0.8 -0.7 1.4 -0.2 -0.6 -0.6 -0.7 0.6 0.6 0.8 0.7 0.8 0.6 0.7
Hair/balding pattern: Pattern 2 0.1 0.1 0.7 -0.1 -0.3 0.3 -0.6 0.4 -0.0 -0.2 -0.1 0.5 -0.0 -0.3 -0.7 0.9 -0.6 -0.3 -0.3 -0.1 -0.2 0.2 0.1 -0.2 0.2 -0.1 0.1
Had menopause 0.8 1.0 3.7 -1.7 -0.1 -0.6 0.2 -0.4 -1.8 -0.4 -1.8 -0.4 0.9 -1.3 1.1 -0.4 -1.3 -0.2 -0.0 0.5 -1.9 -0.6 -0.7 -1.3 0.0 -1.2 -0.8
Had other major operations 0.3 0.4 2.3 0.4 -0.6 -0.0 0.2 0.5 0.2 0.2 0.3 -1.5 -0.5 0.1 0.1 1.3 -0.7 -0.6 -0.6 -0.7 0.4 0.5 0.6 0.5 0.6 0.4 0.6
Forced vital capacity (FVC) 1.3 5.0 11.0 2.7 -1.8 2.5 -2.2 2.8 2.6 1.9 2.6 -0.1 -2.3 2.6 -1.4 3.3 -1.1 -1.8 -1.9 -2.1 2.5 2.1 2.1 2.5 1.8 2.5 2.2
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 14.7 1.9 -2.1 2.1 -1.4 2.0 2.2 1.1 2.0 3.8 -1.9 1.8 -2.9 0.2 -1.8 -2.1 -2.1 -2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.5 -1.0 -0.6 -0.5 -1.1 0.3 -0.8 -0.9 -1.0 0.4 0.3 -1.0 1.6 -0.3 -0.9 -0.6 -0.6 -0.1 -0.9 0.1 0.0 -0.7 0.6 -0.5 -0.1
Qualifications: None of the above 0.2 0.3 1.0 -0.2 0.8 -0.0 -0.5 -0.3 -0.4 -1.0 -0.1 0.7 0.6 -0.1 -0.5 0.5 1.0 0.8 0.7 0.6 -0.1 -0.7 -0.7 -0.2 -0.8 -0.3 -0.6
Financial difficulties in last 2 years 0.5 0.6 1.2 -0.9 0.7 -1.0 1.1 -0.7 -0.5 -0.8 -0.7 -0.7 0.9 -0.9 1.0 -1.0 0.7 0.6 0.7 0.7 -0.3 -0.8 -0.8 -0.7 -0.7 -0.8 -0.8
Mouth/teeth dental problems 0.4 0.6 2.3 -0.8 0.2 -0.0 -1.5 -0.0 -1.0 -0.7 -0.8 -0.1 0.5 -0.5 1.0 1.5 -0.9 0.3 0.3 0.5 -1.4 -0.5 -0.5 -1.0 -0.2 -0.8 -0.6
Heart attack 0.4 0.5 1.8 -0.9 -0.2 -1.3 0.8 -0.3 -0.6 0.1 -1.1 -0.9 0.2 -0.6 1.3 -0.8 -0.5 -0.2 -0.1 0.3 -1.1 -0.2 -0.1 -0.8 0.1 -0.7 -0.3
Allergy 2.6 6.1 19.3 -2.3 2.8 -1.0 4.4 -2.7 -1.9 -2.1 -2.2 -0.8 2.4 -1.8 1.7 -3.0 2.4 2.9 2.7 2.8 -1.9 -2.5 -2.5 -2.4 -2.7 -2.4 -2.4
Pain all over the body in last month 3.9 4.2 8.6 2.6 -1.8 1.2 -1.5 2.0 2.4 2.3 2.7 0.6 -2.1 2.2 -1.2 1.4 -1.0 -1.7 -1.8 -2.2 2.8 2.0 2.1 2.9 1.8 2.5 2.3
Diabetes (self-reported) 1.1 1.8 3.5 -1.6 1.0 -0.7 1.6 -1.6 -1.6 -1.2 -1.5 -1.3 1.2 -1.2 1.9 -1.4 0.4 1.0 1.0 1.3 -1.6 -1.1 -1.1 -1.7 -1.0 -1.5 -1.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.9 2.5 0.5 -1.0 0.8 -1.5 1.0 0.7 1.4 0.4 0.3 -0.7 0.2 -0.3 1.6 -0.8 -1.1 -1.0 -1.0 0.8 1.0 0.9 0.7 1.1 0.8 0.9
Medication: Ramipril 0.5 0.6 1.8 0.4 -1.1 0.3 -0.4 1.2 0.6 1.4 0.2 -0.0 -1.0 0.8 0.4 -0.3 -1.0 -1.1 -1.0 -0.7 0.4 0.9 0.8 0.3 1.0 0.5 0.8
Medication: Simvastatin 0.0 0.1 0.4 -0.1 -0.1 0.4 -0.4 0.3 -0.1 0.3 -0.1 -0.1 -0.2 0.3 0.4 -0.6 -0.3 -0.2 -0.2 -0.1 -0.1 0.1 0.2 -0.0 0.1 -0.1 0.1
Fluid intelligence score 1.0 2.1 4.3 1.4 -2.0 1.0 0.2 1.2 1.4 0.8 1.5 -0.6 -1.6 1.2 -0.6 -1.0 -1.9 -2.1 -1.9 -1.7 1.1 1.8 1.7 1.4 2.0 1.5 1.7
Illnesses of siblings 0.6 0.9 1.7 -0.7 1.3 -0.6 -0.0 -0.4 -0.7 -1.3 -0.7 -0.5 1.0 -0.7 0.7 1.1 0.5 1.1 1.3 1.2 -0.9 -1.1 -1.1 -0.9 -1.3 -1.0 -1.0
Neuroticism score 0.1 0.2 3.6 0.1 0.2 0.6 -0.7 0.1 -0.1 -0.5 0.2 1.9 0.2 0.1 -0.1 -0.1 0.2 0.3 0.3 0.2 0.2 -0.2 -0.2 0.0 -0.2 -0.1 -0.1
Weight 0.0 0.1 0.6 -0.1 -0.1 0.2 -0.4 0.5 -0.5 -0.3 -0.2 0.8 -0.1 0.1 -0.4 0.1 0.4 -0.2 -0.1 0.0 -0.5 0.0 0.1 -0.3 0.2 -0.2 0.0
Impedance of arm (right) 1.0 4.8 12.5 1.9 -2.4 0.7 -3.5 2.3 2.0 2.0 1.9 -0.6 -2.0 1.8 -1.1 3.3 -2.3 -2.5 -2.4 -2.4 1.9 2.2 2.4 2.2 2.3 2.1 2.3
Arm fat percentage (right) 0.1 0.2 1.0 -0.4 -0.3 -0.7 -0.4 0.4 -0.8 -0.7 -0.3 0.5 0.1 -0.3 0.0 -1.0 0.3 -0.5 -0.3 -0.1 -0.7 0.0 0.1 -0.3 0.4 -0.3 0.0
Trunk fat-free mass 0.1 0.4 1.1 -0.5 0.6 0.1 0.9 -0.3 -0.8 -1.0 -0.5 -0.2 0.5 -0.4 0.2 -0.6 1.0 0.5 0.6 0.8 -0.7 -0.7 -0.6 -0.8 -0.6 -0.7 -0.7
Hip circumference 0.2 0.7 2.5 0.6 -0.7 0.6 -1.6 1.4 0.3 -0.3 0.6 1.6 -0.6 0.5 -1.2 0.3 0.2 -0.9 -0.7 -0.7 0.4 0.6 0.7 0.6 0.8 0.6 0.7
Time employed in main current job 3.2 3.7 6.3 1.8 -2.0 1.1 -1.9 2.4 2.0 0.9 2.0 0.7 -1.7 1.4 -1.9 2.3 -1.4 -2.0 -2.0 -2.2 2.5 2.0 2.0 2.4 2.0 2.2 2.3
Alcohol intake versus 10 years previously 0.6 0.9 3.5 0.7 -1.1 1.4 -1.9 0.9 0.9 0.0 0.5 0.3 -1.2 1.0 -0.4 0.3 -0.8 -1.3 -1.2 -0.9 0.7 1.1 1.1 0.7 1.1 0.8 1.1
Father’s age at death 0.3 0.4 1.0 -0.6 0.5 -0.5 -0.5 0.0 -0.8 -0.4 -0.7 -1.0 0.5 -0.5 0.8 0.3 -0.2 0.4 0.6 0.7 -0.7 -0.7 -0.7 -0.7 -0.6 -0.7 -0.7
Worrier / anxious feelings 0.2 0.4 1.2 -0.7 0.3 0.2 -0.4 -0.1 -1.1 -1.1 -0.7 0.6 0.5 -0.5 1.0 0.3 -0.4 0.3 0.3 0.8 -1.0 -0.5 -0.5 -1.1 -0.3 -0.9 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 6.2 0.5 0.1 0.3 -0.4 0.0 0.6 -0.2 0.3 -0.1 -0.5 1.1 0.3 2.5 0.3 0.2 0.1 -0.0 0.4 0.1 0.2 0.1 -0.1 0.3 0.2
Falls in the last year 2.1 2.8 6.4 -1.8 1.7 -1.7 2.5 -1.8 -1.9 -1.2 -1.7 0.2 1.9 -1.6 1.0 -1.5 1.5 1.8 1.8 1.7 -1.6 -1.8 -1.7 -1.6 -1.7 -1.8 -1.7
Hair/balding pattern: Pattern 3 3.0 4.5 8.6 -1.9 2.3 -2.0 2.7 -2.5 -2.1 -1.4 -1.9 -0.3 2.0 -1.7 1.6 -2.9 1.8 2.3 2.3 2.2 -2.1 -2.3 -2.2 -2.0 -2.3 -2.2 -2.3
Number of live births 0.7 0.9 3.3 1.1 -0.4 0.8 -1.8 1.0 1.4 -0.0 0.8 0.8 -0.9 0.9 -1.4 1.3 0.0 -0.4 -0.4 -0.8 1.6 0.7 0.6 1.4 0.3 1.2 0.8
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 7.7 2.3 -1.7 2.5 -2.0 2.8 2.3 1.3 2.2 -0.1 -2.1 2.4 -0.8 2.4 -0.7 -1.8 -1.8 -2.0 2.3 1.9 2.0 2.3 1.7 2.3 2.1
Pulse rate 0.1 0.2 0.9 0.6 0.1 0.8 -0.9 0.1 0.2 0.9 0.6 0.2 -0.5 0.9 0.6 0.1 -0.2 0.1 0.1 0.2 -0.3 0.1 0.0 -0.2 -0.1 0.2 -0.0
Happiness 0.4 0.5 2.5 -0.6 -0.7 0.5 -0.1 0.2 -0.4 0.9 -0.8 1.2 -0.4 -0.0 0.8 -1.6 -1.2 -0.9 -0.8 -0.2 -1.0 0.4 0.4 -0.7 0.7 -0.4 0.2
Noisy workplace 1.5 1.8 6.9 1.5 -0.9 1.6 -2.6 1.1 1.6 1.8 1.4 1.3 -1.3 1.8 -1.0 0.5 -0.8 -0.9 -0.8 -1.1 1.5 1.1 1.0 1.3 0.9 1.5 1.1
Qualifications: A levels/AS levels or equivalent 0.7 1.6 4.0 -1.0 1.1 -1.0 1.9 -1.3 -0.8 -1.9 -0.7 -2.0 1.4 -1.9 1.3 -0.7 1.2 1.2 1.2 1.1 -0.6 -1.2 -1.1 -0.7 -1.1 -1.1 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.5 0.3 -0.3 0.2 0.5 -0.0 0.6 0.7 0.1 -0.5 -0.5 0.7 0.6 -1.2 -0.0 -0.2 -0.3 -0.3 0.5 0.4 0.4 0.4 0.3 0.4 0.4
Mouth/teeth dental problems: Dentures 0.3 0.4 1.4 0.9 -0.2 -0.2 1.1 0.3 0.7 0.5 0.7 0.2 -0.6 0.7 -1.2 -1.1 0.5 -0.3 -0.2 -0.3 1.1 0.3 0.4 1.0 0.2 0.7 0.5
Asthma 0.7 1.3 6.2 0.6 -1.2 -0.6 -2.5 0.8 0.4 0.9 0.6 1.3 -0.9 0.5 -2.0 1.7 -1.4 -1.2 -1.1 -1.2 0.3 1.0 0.9 0.7 1.1 0.8 0.9
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 3.7 -0.6 -0.1 0.5 -0.4 0.6 -0.5 -0.1 -0.9 -0.8 0.0 -0.3 0.7 1.9 -0.0 -0.0 -0.1 0.0 -0.9 -0.1 -0.0 -0.5 0.1 -0.5 -0.2
Medication: Cholesterol lowering 0.4 0.7 1.3 0.7 -0.8 0.3 -0.2 0.7 0.9 0.6 0.8 0.9 -0.8 0.8 -0.6 -1.1 -0.8 -0.8 -0.8 -0.9 1.1 1.0 0.9 0.9 0.8 0.9 1.0
Depression (self-reported) 0.3 0.3 1.2 -0.4 0.3 -0.5 0.6 -0.7 -0.9 -0.6 -0.3 -0.5 0.3 -0.1 1.1 0.1 -0.4 0.3 0.3 0.6 -1.0 -0.5 -0.4 -0.9 -0.3 -0.7 -0.6
Medication: Lansoprazole 0.6 0.7 1.5 0.7 -1.0 0.5 -0.3 0.8 0.5 0.9 0.6 0.1 -0.9 1.1 -0.5 -0.7 -1.2 -1.1 -1.0 -0.9 0.6 0.9 0.9 0.8 0.9 0.8 0.9
Prospective memory result 0.4 0.5 3.1 0.3 -0.1 0.8 -1.8 0.8 0.4 0.5 0.1 0.8 -0.3 0.8 -0.7 1.5 0.3 -0.0 -0.1 -0.4 1.0 0.3 0.2 0.7 0.0 0.5 0.4
Lung cancer (father) 3.8 4.4 10.2 2.0 -2.0 1.6 -1.9 1.7 1.8 2.5 2.0 3.0 -2.0 1.8 -3.2 -0.9 -2.5 -2.0 -2.0 -2.2 1.9 2.1 2.0 2.2 2.0 2.2 2.1
Illnesses of mother 2.7 3.3 7.0 -1.3 2.6 -1.1 1.3 -1.5 -1.2 -1.9 -1.3 -0.2 2.0 -1.4 1.1 -1.1 2.4 2.6 2.6 2.2 -1.1 -2.2 -2.3 -1.3 -2.5 -1.5 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.5 11.8 2.7 -2.6 2.6 -2.6 3.4 2.7 1.4 2.5 0.0 -2.7 2.5 -1.3 2.9 -1.7 -2.6 -2.6 -2.8 2.6 2.7 2.7 2.8 2.6 2.8 2.7
Pulse wave Arterial Stiffness index 1.2 1.4 3.5 1.3 -1.4 0.8 -0.5 0.8 1.2 0.8 1.1 -0.4 -1.6 1.9 -0.2 -0.5 -1.5 -1.5 -1.3 -1.2 1.2 1.3 1.4 1.0 1.3 1.3 1.3
Impedance of arm (left) 1.0 4.8 12.3 2.0 -2.2 1.1 -3.5 2.2 2.2 2.2 1.9 -0.6 -2.0 1.9 -1.2 3.4 -2.1 -2.1 -2.2 -2.3 2.0 2.2 2.2 2.4 2.2 2.2 2.3
Arm fat mass (right) 0.0 0.2 0.9 -0.1 -0.4 -0.3 -0.5 0.6 -0.6 -0.5 -0.1 1.0 -0.1 -0.0 -0.4 -0.9 0.3 -0.6 -0.4 -0.2 -0.4 0.2 0.3 -0.2 0.5 -0.1 0.2
Trunk predicted mass 0.1 0.5 1.1 -0.6 0.7 0.0 0.9 -0.3 -0.9 -1.1 -0.6 -0.2 0.6 -0.5 0.2 -0.7 1.0 0.5 0.6 0.8 -0.8 -0.7 -0.6 -0.9 -0.6 -0.8 -0.7
Standing height 0.6 5.7 17.5 2.3 -2.2 2.2 -3.1 2.7 2.4 2.5 2.2 0.2 -2.4 2.4 -1.8 4.2 -1.6 -2.2 -2.2 -2.3 2.3 2.3 2.4 2.3 2.2 2.4 2.4
Length of working week for main job 0.4 0.5 2.2 -0.9 0.7 -0.2 0.2 -0.5 -0.5 0.0 -0.9 1.1 0.6 -0.4 0.3 -0.3 1.5 0.5 0.7 0.7 -0.7 -0.6 -0.6 -0.8 -0.7 -0.8 -0.6
Exposure to tobacco smoke at home 2.7 3.1 4.8 1.7 -2.1 1.7 -2.1 1.8 1.7 0.5 1.7 1.2 -1.8 1.6 -1.3 0.4 -1.6 -2.1 -2.1 -2.1 1.3 2.0 2.0 1.6 2.2 1.8 1.8
Breastfed as a baby 1.0 1.2 2.7 -1.4 0.9 -1.1 1.6 -1.3 -1.4 -1.5 -1.3 0.1 1.2 -1.5 0.4 -0.5 0.4 0.9 0.8 0.9 -1.0 -1.0 -0.9 -1.1 -0.8 -1.3 -1.0
Tense / ‘highly strung’ 2.7 4.4 8.5 2.0 -2.0 2.9 -2.8 2.4 2.1 2.4 1.9 1.5 -1.9 1.9 -2.0 2.1 -2.1 -1.8 -1.9 -2.1 2.0 2.0 1.9 2.0 2.0 2.1 2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 3.5 -0.0 0.2 -1.0 0.4 -0.4 -0.4 -1.0 0.1 0.8 0.1 0.3 -0.1 -1.9 0.4 0.2 0.3 0.3 -0.4 -0.4 -0.1 -0.4 -0.2 -0.3 -0.3
Hair/balding pattern: Pattern 4 3.4 8.2 12.3 3.1 -3.1 2.7 -0.5 2.4 3.5 1.1 3.5 0.4 -3.0 2.6 -2.6 -2.8 -1.4 -3.3 -3.3 -3.2 3.1 3.4 3.2 3.0 3.3 3.3 3.3
Birth weight of first child 1.5 2.8 4.2 -1.6 1.9 -1.7 1.2 -1.3 -2.0 -1.4 -1.6 0.2 1.9 -1.7 1.6 0.3 2.0 1.9 1.9 1.8 -1.8 -1.8 -1.8 -1.8 -1.8 -1.8 -1.8
Peak expiratory flow (PEF) 1.7 3.9 6.8 2.1 -2.0 2.5 -2.2 2.6 2.2 1.2 1.8 -1.0 -2.2 2.2 0.0 1.6 -1.2 -2.0 -2.0 -2.1 2.0 2.0 2.1 2.3 1.9 2.2 2.1
Pulse wave reflection index 0.2 0.2 1.0 -0.3 -0.6 -0.4 1.0 -0.2 0.1 -0.3 -0.3 -0.6 -0.1 -0.0 0.5 -0.7 -0.6 -0.6 -0.6 -0.3 0.3 0.4 0.4 -0.0 0.6 0.0 0.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 0.5 -0.3 0.4 -0.3 0.6 0.5 0.7 0.3 0.7 -0.5 0.8 0.0 0.2 0.2 -0.4 -0.3 -0.3 0.5 0.3 0.4 0.4 0.3 0.4 0.3
Loud music exposure frequency 4.9 5.4 8.0 2.4 -2.4 1.6 -2.8 2.4 2.4 2.3 2.2 1.8 -2.6 2.5 -2.4 1.9 -2.7 -2.5 -2.4 -2.3 1.8 2.5 2.5 1.9 2.4 2.3 2.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.0 3.6 -1.2 0.7 -1.2 0.6 -0.8 -1.0 -1.1 -1.1 -1.9 1.2 -1.7 1.4 0.4 0.1 0.8 0.8 0.8 -0.7 -0.8 -0.9 -0.9 -0.7 -1.1 -0.9
Mouth/teeth dental problems: Bleeding gums 1.7 2.1 4.2 -1.7 1.3 -2.0 2.0 -1.5 -1.3 -1.3 -1.7 -0.6 1.6 -1.8 0.9 -2.0 1.7 1.2 1.3 1.3 -1.1 -1.4 -1.5 -1.2 -1.3 -1.4 -1.4
Blood clot in the leg (DVT) 0.1 0.1 0.6 -0.2 0.2 0.3 -0.0 0.3 -0.4 -0.5 -0.1 -0.1 0.3 -0.4 0.8 0.0 0.3 0.1 0.2 0.1 0.3 -0.2 -0.4 0.1 -0.3 -0.0 -0.2
Medication: Paracetamol 4.3 7.2 16.6 2.9 -2.3 2.2 -2.9 2.7 2.5 4.1 2.7 1.7 -2.7 3.2 -2.5 3.5 -1.7 -2.2 -2.4 -2.6 2.8 2.5 2.6 2.8 2.3 2.8 2.6
Headache pain in last month 2.6 4.5 6.9 2.3 -1.8 2.2 -2.6 2.3 2.4 2.1 2.0 1.5 -2.3 2.5 -1.3 2.6 -1.3 -1.9 -1.8 -2.1 2.4 2.1 2.0 2.2 1.8 2.3 2.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 5.0 -0.2 -0.3 0.1 -1.3 0.3 0.0 0.5 -0.4 0.4 -0.1 -0.0 -0.2 2.2 -0.6 -0.2 -0.2 -0.1 -0.4 0.0 0.1 -0.3 0.2 -0.1 -0.1
Glaucoma (self-reported) 0.4 0.4 5.7 0.0 -0.2 -0.1 0.5 -0.5 0.0 -1.2 0.0 -2.4 -0.0 -0.2 1.5 -0.2 0.3 -0.1 -0.2 -0.1 -0.0 0.0 0.0 0.1 0.2 0.1 0.0
Gout (self-reported) 1.3 1.7 4.4 -1.1 1.7 -1.0 1.4 -1.7 -1.1 0.1 -1.1 1.2 1.3 -0.9 -0.0 -0.4 2.1 1.6 1.6 1.5 -0.9 -1.5 -1.5 -1.2 -1.7 -1.2 -1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.9 -1.2 0.7 -0.7 1.2 -0.8 -1.1 -1.3 -1.4 0.8 0.7 -0.6 0.2 -0.4 0.1 0.6 0.7 0.9 -1.1 -0.8 -0.8 -1.1 -0.7 -1.0 -0.9
Medication: Amlodipine 0.3 0.5 2.8 -0.5 -0.2 -0.3 0.8 -0.4 -0.8 -0.8 -0.3 -0.9 0.1 -0.3 1.7 -0.7 -1.3 -0.2 -0.2 0.1 -1.1 -0.1 -0.1 -0.9 0.2 -0.5 -0.4
Medication: Ventolin 100micrograms inhaler 0.8 1.0 6.5 0.7 -0.5 0.7 -2.2 1.0 0.6 0.7 0.7 1.1 -0.5 0.4 -1.7 2.6 -0.2 -0.5 -0.5 -0.7 0.7 0.6 0.5 0.9 0.5 0.7 0.6
Birth weight 4.3 9.3 17.7 -2.6 3.6 -3.3 3.4 -3.2 -2.8 -3.0 -2.2 -0.8 3.3 -2.9 1.4 -1.6 4.2 3.6 3.6 3.4 -2.4 -3.4 -3.4 -2.8 -3.5 -3.0 -3.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 2.0 0.3 -1.0 1.4 -1.4 1.1 0.4 -0.4 0.4 -0.8 -0.5 0.1 0.3 0.2 -0.6 -1.0 -1.0 -0.8 0.4 0.8 0.7 0.7 1.0 0.6 0.8
High blood pressure (siblings) 0.2 0.2 2.8 -0.3 -0.4 -0.2 0.8 -0.3 -0.1 0.2 -0.2 -0.6 0.1 -0.5 0.2 -1.7 0.0 -0.4 -0.4 -0.4 0.0 0.3 0.2 0.1 0.4 0.1 0.1
Forced vital capacity (FVC), Best measure 2.2 8.1 13.6 3.2 -2.7 2.6 -2.8 3.7 3.1 2.1 3.0 0.2 -3.0 2.9 -1.9 3.5 -1.9 -2.7 -2.8 -3.0 3.0 2.9 3.0 3.2 2.8 3.2 3.0
Body fat percentage 0.3 1.3 3.0 0.8 -1.5 0.6 -1.7 1.7 0.6 0.9 0.7 1.1 -1.2 0.9 -0.9 0.4 -0.7 -1.6 -1.5 -1.3 0.5 1.3 1.4 0.8 1.6 0.9 1.3
Leg fat percentage (right) 0.1 0.5 1.8 0.3 -0.9 0.3 -1.0 1.1 0.2 0.6 0.2 1.4 -0.7 0.6 -0.8 -0.3 0.0 -1.0 -0.8 -0.6 0.2 0.8 0.8 0.4 0.9 0.5 0.7
Arm fat-free mass (right) 0.0 0.1 0.8 -0.1 0.2 0.5 0.5 0.2 -0.2 -0.6 -0.2 0.6 0.1 -0.0 -0.4 -0.9 0.9 0.1 0.2 0.2 -0.2 -0.1 -0.1 -0.2 -0.1 -0.2 -0.2
Exposure to tobacco smoke outside home 0.3 0.5 4.6 -0.5 0.4 0.5 -0.8 -0.2 -0.6 -0.0 -0.5 2.1 0.2 0.1 0.8 0.2 0.6 0.5 0.4 0.5 -0.8 -0.4 -0.4 -0.9 -0.4 -0.6 -0.6
Comparative body size at age 10 6.4 17.8 24.1 -4.2 4.2 -4.5 4.9 -4.7 -4.5 -4.1 -3.8 -1.6 4.4 -4.1 3.6 -4.7 2.8 4.2 4.2 4.4 -4.5 -4.4 -4.4 -4.4 -4.2 -4.5 -4.5
Number of full brothers 0.2 0.2 1.5 -0.2 0.3 0.8 -0.3 -0.1 -0.1 -0.9 -0.2 0.6 0.3 -0.2 -0.4 1.2 1.2 0.5 0.3 0.3 0.2 -0.4 -0.3 -0.0 -0.3 -0.2 -0.2
Worry too long after embarrassment 0.1 0.1 0.5 0.4 -0.1 -0.5 -0.3 -0.1 0.4 0.3 0.3 -0.4 -0.3 0.2 -0.3 0.7 0.3 0.1 -0.0 -0.1 0.7 0.1 0.3 0.5 0.1 0.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.3 0.9 -0.8 0.5 -0.9 0.7 0.7 0.5 0.8 1.8 -1.0 1.2 -0.8 0.0 -1.2 -0.8 -0.8 -0.8 0.6 0.8 0.9 0.7 0.8 0.7 0.9
Wheeze or whistling in the chest in last year 0.3 0.5 3.9 0.3 -0.1 -0.3 -1.6 0.1 0.2 0.8 0.2 1.6 -0.3 0.4 -1.5 2.0 0.2 -0.0 -0.1 -0.3 0.3 0.2 0.2 0.4 0.0 0.3 0.2
Number of children fathered 0.6 0.6 2.4 1.0 -0.8 0.6 -0.3 0.9 0.8 0.2 1.0 0.7 -1.1 1.1 -0.7 1.5 -0.6 -0.6 -0.7 -0.6 0.7 0.8 0.8 0.5 0.8 0.8 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.6 1.4 -0.6 1.0 -1.2 0.2 -1.1 -0.9 0.5 -0.8 0.4 0.5 -0.1 -0.3 -0.7 0.4 1.0 0.9 0.8 -1.1 -0.9 -0.9 -0.8 -1.0 -0.7 -1.0
Age at first live birth 0.9 1.6 7.2 -0.5 1.2 -0.9 2.7 -1.5 -0.8 -0.9 -0.4 -2.3 0.9 -0.7 1.5 -2.3 1.1 1.2 1.2 1.0 -0.8 -1.1 -0.9 -0.5 -1.2 -0.9 -0.9
Pulse wave peak to peak time 0.8 0.9 2.6 -1.0 1.2 -0.5 0.1 -0.4 -0.9 -0.4 -0.9 0.4 1.4 -1.6 -0.0 1.0 1.3 1.3 1.1 0.9 -0.8 -1.1 -1.2 -0.6 -1.1 -1.0 -1.0
Health satisfaction 0.3 0.3 2.0 -0.0 0.4 0.5 0.1 -0.4 -0.2 1.1 0.1 -1.4 0.2 0.0 0.8 1.1 0.5 0.4 0.4 0.6 -0.4 -0.4 -0.3 -0.6 -0.4 -0.4 -0.4
Shortness of breath walking on level ground 1.6 1.9 3.1 -1.2 1.7 -0.5 1.5 -1.6 -1.3 -1.4 -1.3 -0.8 1.3 -1.1 1.2 -0.2 1.5 1.7 1.8 1.6 -1.3 -1.6 -1.6 -1.3 -1.7 -1.4 -1.5
Qualifications: College or University degree 0.9 2.9 8.5 -1.4 1.8 -1.5 2.9 -2.2 -1.4 -0.0 -1.5 -1.9 1.4 -1.3 1.9 -1.7 1.9 1.8 1.9 1.6 -1.3 -1.7 -1.6 -1.4 -1.8 -1.6 -1.6
Eye problems/disorders: None of the above 0.1 0.1 0.3 -0.4 0.1 0.0 0.6 0.1 -0.4 -0.3 -0.3 0.4 0.1 -0.3 0.2 0.3 0.5 -0.1 0.0 0.0 -0.5 -0.1 -0.0 -0.5 -0.1 -0.5 -0.2
Mouth/teeth dental problems: Loose teeth 1.7 2.0 5.8 1.7 -1.2 2.4 -1.2 1.4 1.5 1.5 1.8 1.0 -1.4 1.6 -1.3 0.8 -0.7 -1.2 -1.2 -1.4 1.4 1.3 1.3 1.6 1.2 1.7 1.4
Emphysema/chronic bronchitis 3.0 3.4 6.2 -1.0 2.5 -0.4 1.7 -2.5 -1.5 -2.3 -0.8 -1.8 1.7 -0.9 1.0 1.1 2.4 2.4 2.4 2.2 -1.3 -2.2 -2.1 -1.4 -2.4 -1.5 -2.0
Medication for pain relief, constipation, heartburn 4.3 7.4 9.8 -2.7 2.8 -2.7 2.5 -3.1 -2.7 -3.0 -2.3 -1.0 3.0 -3.1 2.1 -2.4 3.0 2.6 2.8 2.9 -2.5 -2.9 -3.0 -2.7 -2.8 -2.8 -2.9
Neck or shoulder pain in last month 2.8 3.9 7.3 2.0 -1.8 2.4 -2.3 2.6 2.0 1.1 1.7 0.7 -1.9 2.0 -1.3 2.7 -1.2 -1.8 -1.8 -2.1 2.5 2.0 2.0 2.3 1.8 2.2 2.1
Medication: Blood pressure 0.3 0.6 6.8 0.1 0.4 -0.6 2.0 -0.6 -0.1 -0.6 0.3 -0.6 0.2 -0.2 0.5 -2.6 0.5 0.4 0.4 0.3 0.2 -0.2 -0.3 0.1 -0.4 -0.1 -0.1
Angina (self-reported) 0.2 0.2 3.3 -0.4 -0.1 -0.3 0.6 -0.2 0.1 -0.6 -0.3 0.9 0.2 -0.4 -0.1 -1.8 -0.0 -0.1 0.0 0.2 0.2 -0.0 -0.1 -0.2 0.0 -0.2 0.0
Migraine (self-reported) 2.4 2.9 10.4 1.4 -1.6 1.9 -2.2 1.9 1.2 1.9 1.2 0.6 -1.6 1.8 -1.8 3.2 -1.3 -1.7 -1.7 -1.7 1.4 1.6 1.6 1.5 1.6 1.6 1.6
Medication: Ibuprofen 0.6 0.7 2.4 -1.0 0.2 -0.1 -0.4 0.1 -1.1 -0.7 -1.2 -1.3 0.5 -0.9 1.5 1.5 0.2 0.2 0.3 0.4 -1.4 -0.5 -0.4 -1.0 -0.2 -0.9 -0.7
Medication: Allopurinol 0.6 0.8 3.1 -0.7 1.2 -0.2 0.8 -0.9 -0.8 0.5 -0.6 1.1 0.8 -0.4 -0.1 0.1 1.8 1.3 1.2 1.1 -0.6 -1.0 -1.1 -0.9 -1.2 -0.7 -1.0
Medication: Omeprazole 1.6 2.0 4.8 1.3 -1.4 1.3 -2.2 1.6 1.4 1.2 1.2 0.7 -1.4 1.3 -1.3 0.1 -0.4 -1.4 -1.4 -1.5 1.7 1.5 1.4 1.7 1.4 1.5 1.6
Medication: Seretide 50 evohaler 0.1 0.1 0.6 -0.3 -0.1 -0.2 -0.8 0.4 -0.4 -0.7 -0.2 0.6 0.2 -0.7 -0.1 -0.4 0.1 0.0 -0.2 0.0 -0.5 0.0 -0.0 -0.3 0.2 -0.3 -0.1
Mean time to correctly identify matches 0.1 0.1 0.9 -0.2 -0.1 -0.1 0.9 -0.4 -0.6 -0.5 -0.1 -0.8 0.1 -0.3 0.4 -0.1 -0.2 -0.0 -0.1 0.1 -0.6 -0.1 -0.2 -0.4 0.1 -0.3 -0.2
Heart disease (mother) 4.1 5.0 9.4 1.7 -2.7 2.0 -1.8 2.3 2.0 2.3 1.4 1.9 -2.5 2.3 -1.6 0.9 -3.1 -2.8 -2.8 -2.5 1.6 2.6 2.6 1.7 2.7 2.0 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.2 -1.4 0.6 -1.5 -0.6 0.1 -1.6 -1.6 -1.4 -1.0 1.0 -1.2 1.5 1.8 -0.1 0.6 0.6 0.7 -1.4 -0.9 -0.9 -1.2 -0.6 -1.2 -0.9
Whole body fat mass 0.2 0.8 2.0 0.6 -1.2 0.5 -1.2 1.4 0.3 0.4 0.6 1.0 -0.9 0.7 -0.8 0.0 -0.3 -1.3 -1.2 -1.0 0.3 1.0 1.1 0.6 1.2 0.7 1.0
Leg fat mass (right) 0.1 0.4 1.5 0.4 -0.7 0.4 -0.7 1.0 0.1 0.3 0.3 1.2 -0.6 0.5 -0.7 -0.4 0.2 -0.8 -0.7 -0.5 0.1 0.6 0.7 0.3 0.8 0.4 0.6
Arm predicted mass (right) 0.0 0.2 0.9 -0.3 0.5 0.5 0.6 -0.0 -0.4 -0.5 -0.3 0.7 0.2 -0.2 -0.4 -0.5 1.0 0.4 0.4 0.5 -0.4 -0.4 -0.4 -0.5 -0.4 -0.4 -0.4
Pulse rate, automated reading 0.8 2.6 6.1 2.2 -1.2 1.2 -2.3 1.8 1.4 1.1 2.5 1.4 -1.5 1.6 -2.5 2.0 -1.1 -1.1 -1.2 -1.4 1.5 1.4 1.3 1.5 1.1 1.7 1.4
Alcohol intake frequency. 0.2 0.5 1.8 1.0 -0.7 0.5 -0.6 0.4 0.5 0.7 0.9 -0.1 -1.0 1.3 -0.4 0.7 -0.4 -0.8 -0.7 -0.7 0.3 0.6 0.8 0.5 0.7 0.7 0.6
Comparative height size at age 10 0.1 0.8 4.0 -1.1 0.5 -0.1 -1.0 0.2 -1.0 -0.4 -1.1 -0.3 0.8 -0.8 1.0 2.0 -0.3 0.4 0.5 0.8 -1.2 -0.8 -0.7 -1.2 -0.5 -1.1 -0.9
Number of full sisters 2.9 3.5 9.3 2.2 -1.4 1.3 -2.2 1.9 2.6 1.3 2.0 0.6 -1.8 1.7 -2.4 1.3 -0.1 -1.2 -1.4 -1.9 3.1 1.8 1.7 2.6 1.4 2.4 2.0
Suffer from ‘nerves’ 3.6 5.6 13.0 2.2 -2.4 1.7 -3.6 2.5 2.4 2.6 1.8 1.6 -2.6 2.6 -1.7 2.4 -2.8 -2.3 -2.3 -2.4 2.2 2.4 2.3 2.2 2.3 2.4 2.4
Overall health rating 2.8 6.0 14.8 3.0 -1.7 2.8 -2.1 1.9 3.0 3.9 2.9 1.3 -2.6 3.1 -2.2 2.5 -0.8 -1.6 -1.7 -2.1 3.2 2.2 2.3 2.8 1.7 2.8 2.4
Chest pain or discomfort 1.1 1.5 2.5 -1.2 1.5 -0.9 0.4 -1.0 -1.4 -0.9 -1.4 0.7 1.2 -1.0 1.0 0.6 1.4 1.5 1.6 1.4 -1.1 -1.4 -1.4 -1.3 -1.5 -1.4 -1.4
Had major operations 1.9 2.2 7.7 -0.9 1.9 -0.7 1.8 -1.7 -1.3 -0.7 -0.8 0.7 1.5 -1.1 0.1 -0.7 2.8 1.8 1.9 1.8 -0.9 -1.8 -1.6 -1.3 -1.9 -1.3 -1.7
Age at last live birth 0.4 0.6 3.6 0.8 -0.3 0.6 1.1 0.0 1.0 -0.2 0.9 -1.6 -0.5 0.7 0.3 -1.9 0.0 -0.3 -0.2 -0.5 0.7 0.4 0.5 0.8 0.3 0.7 0.5
Family relationship satisfaction 2.0 2.5 6.4 -1.6 1.4 -1.4 1.5 -1.8 -1.8 -1.4 -1.6 -1.1 1.4 -1.4 1.9 -2.5 0.8 1.2 1.4 1.6 -1.9 -1.5 -1.5 -1.7 -1.4 -1.6 -1.6
Leg pain on walking 0.6 0.7 2.7 0.9 -0.8 1.0 -1.0 1.1 0.8 1.6 1.1 0.1 -0.7 0.6 -0.8 0.6 -0.5 -0.9 -0.8 -0.8 0.8 0.8 0.8 0.7 0.8 0.8 0.8
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.6 1.3 -1.0 1.3 -1.3 0.9 1.5 0.6 1.3 0.2 -1.3 1.6 -1.3 0.2 -0.7 -1.1 -1.1 -1.3 1.1 1.2 1.2 1.2 1.1 1.4 1.1
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.2 0.5 -1.1 0.5 -0.5 1.1 0.2 1.0 0.4 0.7 -1.0 0.8 -0.3 0.5 -0.7 -1.1 -1.0 -0.6 -0.0 0.8 0.8 0.1 1.1 0.5 0.7
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.6 -0.0 0.0 0.2 0.5 -0.2 -0.4 -0.1 0.1 0.5 0.1 -0.2 -0.4 -0.8 -0.4 -0.1 0.0 0.2 -0.7 -0.1 -0.1 -0.5 -0.1 -0.3 -0.2
Medication: Aspirin 2.0 2.6 4.6 1.4 -1.7 1.6 -0.4 1.1 1.6 2.0 1.1 1.8 -1.9 2.1 -1.8 -0.3 -2.1 -1.5 -1.7 -1.6 1.4 1.8 1.8 1.5 1.8 1.6 1.8
Supplements: Vitamin C 1.2 1.5 2.3 -0.9 1.4 -1.5 1.4 -1.4 -1.3 -0.4 -0.4 -0.5 1.5 -1.3 0.2 0.6 0.9 1.4 1.4 1.3 -1.1 -1.5 -1.3 -1.2 -1.4 -1.3 -1.4
Knee pain experienced in last month 0.1 0.1 0.6 -0.6 -0.1 -0.2 -0.3 -0.2 -0.6 -0.3 -0.7 0.1 0.3 -0.8 -0.2 -0.1 -0.2 -0.0 -0.1 0.1 -0.3 -0.1 -0.1 -0.4 0.1 -0.4 -0.2
Hypertension (Self-reported) 0.3 0.7 3.4 0.9 -0.4 0.3 1.6 -0.1 0.6 1.1 1.0 0.7 -0.6 0.8 -1.2 -1.8 0.2 -0.5 -0.4 -0.6 1.2 0.5 0.6 0.9 0.5 0.8 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 5.3 1.5 -0.7 1.4 -1.2 1.6 0.7 0.9 1.5 0.9 -0.9 0.9 -2.1 2.3 0.7 -0.6 -0.6 -1.0 1.3 0.7 0.9 1.5 0.7 1.1 0.9
Illnesses of father: Heart disease 1.2 1.7 4.2 1.2 -1.4 2.1 -0.2 0.5 1.3 1.4 0.9 -1.6 -1.7 1.6 0.2 -0.6 -1.5 -1.5 -1.5 -1.3 0.7 1.5 1.5 1.0 1.4 1.2 1.3
Illnesses of siblings: Diabetes 1.0 1.2 2.1 1.0 -1.3 1.1 -0.4 1.2 1.4 1.5 1.0 0.6 -1.3 1.0 -0.9 0.2 -0.7 -1.3 -1.3 -1.1 1.1 1.3 1.3 1.0 1.3 1.1 1.2
Smoking status: Previous 0.1 0.2 0.9 -0.5 0.1 -0.3 -0.6 0.0 -0.2 -1.0 -0.6 0.8 0.2 -0.4 0.7 0.4 0.2 0.0 0.1 0.2 -0.5 -0.2 -0.1 -0.5 -0.1 -0.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.2 10.4 3.0 -1.2 1.5 -2.2 1.7 2.6 2.2 3.2 -0.8 -2.1 2.6 -1.2 3.0 -0.3 -1.1 -1.2 -1.7 2.8 1.7 1.8 2.6 1.2 2.5 2.0
Whole body fat-free mass 0.0 0.2 0.7 -0.2 0.3 0.3 0.6 0.0 -0.5 -0.8 -0.1 -0.1 0.2 -0.0 -0.0 -0.6 0.8 0.2 0.3 0.4 -0.5 -0.3 -0.2 -0.5 -0.3 -0.4 -0.3
Leg fat-free mass (right) 0.0 0.1 0.6 0.3 -0.1 0.5 -0.0 0.5 -0.1 -0.8 0.4 -0.0 -0.3 0.4 -0.2 -0.2 0.3 -0.2 -0.1 -0.1 -0.2 0.1 0.3 -0.0 0.2 0.1 0.2
Arm fat percentage (left) 0.0 0.1 0.6 -0.2 -0.2 -0.5 -0.5 0.5 -0.6 -0.6 -0.1 0.5 0.1 -0.1 -0.1 -0.8 0.5 -0.3 -0.2 -0.1 -0.5 0.0 0.1 -0.1 0.3 -0.2 0.1
Average weekly red wine intake 2.9 4.2 7.6 -1.6 2.4 -2.1 2.8 -2.4 -2.0 -1.7 -1.4 -0.5 2.1 -1.6 1.5 -2.3 2.2 2.3 2.4 2.2 -1.8 -2.3 -2.2 -1.7 -2.4 -2.0 -2.1
Handedness (chirality/laterality): Left-handed 2.1 2.5 4.2 -1.9 1.6 -0.9 0.6 -1.2 -2.0 -1.1 -1.9 -0.8 1.7 -1.7 1.7 0.9 1.3 1.6 1.6 1.6 -2.0 -1.7 -1.7 -1.9 -1.6 -1.9 -1.8
Mood swings 0.1 0.2 3.1 -0.4 0.0 0.8 -0.2 0.1 -0.5 -0.4 -0.4 1.7 0.1 0.1 0.2 -0.9 0.5 -0.0 -0.0 -0.0 -0.2 -0.0 -0.1 -0.2 0.0 -0.2 -0.1
Loneliness, isolation 0.9 1.2 3.0 -0.6 1.6 0.1 0.5 -0.8 -0.7 -1.5 -0.5 0.2 1.2 -0.6 0.3 1.1 1.7 1.7 1.5 1.1 -0.4 -1.3 -1.3 -0.6 -1.6 -0.8 -1.2
Long-standing illness, disability or infirmity 0.2 0.3 2.1 0.4 -0.3 0.8 -0.8 0.4 0.2 1.4 0.4 0.5 -0.4 0.6 -0.3 0.0 -0.7 -0.4 -0.3 -0.3 0.3 0.3 0.3 0.2 0.3 0.4 0.3
Ever had bowel cancer screening 0.1 0.1 0.6 0.1 0.2 -0.4 0.4 -0.3 -0.5 -0.4 0.2 -0.8 0.1 0.1 -0.0 0.7 0.2 0.2 0.1 0.2 0.0 -0.2 -0.1 0.0 -0.2 -0.1 -0.0
Diabetes diagnosed by doctor 0.4 0.6 1.4 -1.1 0.6 0.1 0.6 -0.8 -1.0 -0.6 -1.1 -0.9 0.8 -0.8 1.2 -0.3 -0.1 0.7 0.6 0.7 -0.9 -0.7 -0.7 -0.9 -0.6 -0.9 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 5.0 -0.5 1.8 -1.5 0.9 -1.3 -0.4 -1.4 -0.3 -0.0 1.1 -0.9 -0.3 -0.5 2.2 1.8 1.8 1.3 -0.2 -1.4 -1.3 -0.5 -1.8 -0.9 -1.2
Friendships satisfaction 1.6 2.0 3.9 -1.7 1.4 -0.6 0.7 -1.6 -1.9 -0.9 -2.0 0.6 1.3 -1.2 1.3 -0.8 1.1 1.4 1.4 1.7 -1.7 -1.5 -1.5 -1.5 -1.4 -1.7 -1.5
Qualifications: nursing, teaching 1.4 2.1 3.7 1.6 -1.4 0.9 -0.8 1.6 1.8 1.7 1.4 -0.3 -1.6 1.7 -0.7 0.4 -1.4 -1.3 -1.4 -1.6 1.8 1.6 1.6 1.9 1.4 1.7 1.8
Commuting to job workplace: Walk 3.6 3.9 10.8 -2.1 1.9 -3.3 1.6 -1.7 -2.3 -1.3 -1.8 -0.4 2.2 -2.4 1.7 -1.9 1.3 1.9 1.8 1.8 -2.0 -2.0 -2.0 -2.0 -1.9 -2.2 -2.1
Eye problems/disorders: Cataract 1.3 1.5 2.9 1.5 -1.1 1.2 -0.8 0.9 1.3 1.5 1.2 0.6 -1.4 1.7 -1.1 -0.1 -1.5 -1.1 -1.0 -1.2 1.3 1.2 1.2 1.4 1.1 1.4 1.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.8 0.6 -0.4 0.9 0.3 0.5 0.6 0.6 0.7 -0.8 -0.7 0.8 -0.8 0.5 -0.3 -0.5 -0.6 -0.7 0.6 0.7 0.6 0.5 0.4 0.6 0.6
Medication for cholesterol 0.1 0.2 1.5 0.0 0.3 -1.2 0.1 -0.3 -0.1 -0.6 0.2 1.2 0.3 -0.4 -0.5 -0.6 0.3 0.3 0.2 0.2 -0.0 -0.1 -0.2 0.1 -0.2 -0.1 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 5.7 1.5 -1.1 1.4 -0.5 1.3 1.5 1.8 1.4 -1.7 -1.3 1.6 0.6 2.4 -1.1 -1.0 -1.1 -1.2 1.6 1.2 1.2 1.4 1.1 1.5 1.2
Back pain experienced in last month 1.5 2.2 7.0 1.2 -1.2 1.6 -2.2 1.9 1.2 0.6 1.3 1.8 -1.3 1.4 -2.1 2.6 -1.2 -1.2 -1.2 -1.4 1.2 1.3 1.2 1.2 1.2 1.4 1.3
Mineral and other dietary supplements 0.3 0.5 3.8 0.5 -0.3 1.9 -0.8 0.8 0.8 -0.9 0.5 -0.2 -0.4 0.5 -0.1 -0.5 0.2 -0.5 -0.3 -0.4 0.8 0.6 0.4 0.7 0.3 0.6 0.6
Breast cancer (self-reported) 0.7 0.8 3.0 -1.3 0.4 -1.7 0.1 -0.5 -1.2 -0.6 -1.1 0.2 1.2 -1.7 0.7 -0.9 0.1 0.4 0.5 0.4 -0.9 -0.7 -0.8 -0.8 -0.4 -1.0 -0.8
Asthma (self-reported) 1.1 2.2 9.3 1.0 -1.5 -0.4 -3.0 1.3 0.9 1.1 0.9 1.7 -1.3 0.9 -2.4 1.8 -1.5 -1.6 -1.5 -1.6 0.8 1.4 1.3 1.2 1.5 1.2 1.3
Osteoporosis (self-reported) 6.6 8.1 12.2 -3.1 3.2 -2.9 2.9 -2.6 -3.0 -2.9 -2.7 -0.5 3.5 -3.4 1.1 -0.6 2.9 3.3 3.2 3.3 -2.1 -3.2 -3.3 -2.7 -3.2 -3.1 -3.0
Osteoarthritis (self-reported) 0.2 0.2 0.8 -0.6 -0.2 0.4 -0.3 -0.1 -0.8 -0.4 -0.6 -0.4 0.4 -0.8 -0.3 0.9 -0.4 -0.2 -0.3 -0.0 -0.7 -0.0 0.0 -0.5 0.3 -0.5 -0.2
Medication: Aspirin 1.3 1.7 3.0 1.2 -1.4 1.2 0.1 0.6 1.4 1.7 0.9 1.3 -1.5 1.7 -1.4 -1.0 -1.7 -1.2 -1.3 -1.3 1.2 1.4 1.5 1.3 1.4 1.3 1.4
Medication: Gliclazide 0.1 0.2 0.6 -0.1 -0.4 -0.0 -0.3 0.3 0.4 0.4 -0.1 -0.1 -0.3 0.1 0.3 -0.6 -0.6 -0.4 -0.5 -0.3 0.8 0.4 0.4 0.4 0.4 0.3 0.5
Illnesses of father: None of the above (group 1) 1.1 1.3 5.4 -0.8 1.3 -1.7 0.5 -0.4 -1.0 -0.4 -0.5 2.3 1.5 -1.5 -0.9 0.1 0.8 1.4 1.4 1.2 -0.5 -1.3 -1.3 -0.7 -1.3 -1.0 -1.2
Smoking status: Current 0.6 1.0 3.9 -1.0 1.0 -2.0 0.7 -1.0 -1.0 -1.1 -0.8 -0.7 1.1 -1.2 0.5 -0.5 0.5 0.8 0.9 1.2 -1.0 -1.1 -1.1 -1.0 -1.0 -1.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.2 1.4 -1.1 1.3 -0.6 1.5 1.0 0.2 1.3 -0.9 -1.2 1.1 -0.1 0.4 -0.8 -1.0 -1.1 -1.4 0.9 1.2 1.2 1.3 1.1 1.3 1.3
Whole body water mass 0.0 0.2 1.0 -0.3 0.4 0.0 0.7 -0.1 -0.7 -1.0 -0.3 -0.1 0.3 -0.2 0.0 -0.7 0.9 0.3 0.4 0.5 -0.6 -0.4 -0.3 -0.6 -0.4 -0.5 -0.4
Leg predicted mass (right) 0.0 0.1 0.6 0.4 -0.2 0.6 -0.1 0.6 -0.1 -0.8 0.5 -0.0 -0.3 0.5 -0.2 -0.2 0.3 -0.3 -0.2 -0.2 -0.1 0.2 0.3 0.0 0.3 0.1 0.2
Arm fat mass (left) 0.0 0.1 0.7 -0.2 -0.2 -0.2 -0.4 0.5 -0.6 -0.5 -0.2 0.8 0.0 -0.1 -0.2 -0.8 0.5 -0.3 -0.2 -0.1 -0.5 0.0 0.1 -0.2 0.3 -0.2 0.0
Number of self-reported non-cancer illnesses 1.7 3.0 4.2 1.8 -2.0 1.1 -1.6 1.7 1.2 1.9 1.9 0.6 -1.8 1.4 -1.9 1.3 -1.8 -2.0 -2.0 -2.0 1.4 1.9 1.9 1.5 2.0 1.7 1.9
Average weekly champagne plus white wine intake 0.6 0.9 5.0 -1.5 0.2 -0.6 -0.1 -0.6 -1.2 -2.2 -1.7 -1.2 1.0 -1.6 0.3 -0.5 -0.5 0.1 0.2 0.4 -0.9 -0.5 -0.6 -0.7 -0.2 -1.0 -0.6
Miserableness 1.3 2.3 2.9 -1.5 1.6 -1.6 0.9 -1.2 -1.6 -1.5 -1.4 0.9 1.6 -1.5 1.4 -1.6 1.5 1.6 1.6 1.7 -1.3 -1.7 -1.6 -1.5 -1.7 -1.7 -1.6
Guilty feelings 0.6 0.9 5.6 1.0 -0.6 1.0 -1.4 1.1 0.8 0.8 1.0 0.5 -0.7 0.6 -0.9 2.4 -0.3 -0.4 -0.5 -0.8 1.3 0.7 0.7 1.0 0.6 0.9 0.7
Wears glasses or contact lenses 0.7 0.8 3.1 -0.7 0.3 -1.7 1.4 -1.8 -1.2 -0.4 -0.6 -0.8 0.6 -0.7 -0.1 -0.8 -0.5 0.3 0.4 0.6 -1.2 -0.7 -0.5 -1.1 -0.4 -0.9 -0.7
Ever taken oral contraceptive pill 0.6 0.6 2.8 0.8 -0.5 0.2 -1.6 0.9 0.8 0.7 0.5 -0.1 -0.9 0.8 -0.4 1.7 0.1 -0.6 -0.5 -0.6 0.9 0.6 0.7 0.9 0.4 0.8 0.7
Hearing aid user 0.1 0.1 0.6 0.2 -0.4 -0.4 0.1 0.1 -0.1 -0.2 0.5 0.6 -0.0 -0.1 -0.8 -0.7 -0.3 -0.3 -0.4 -0.2 -0.1 0.2 0.3 -0.1 0.5 0.1 0.1
Mother’s age at death 0.1 0.2 0.7 -0.3 0.4 -0.1 0.7 -0.3 -0.4 -0.6 -0.1 -0.5 0.6 -0.4 0.8 0.3 0.5 0.4 0.3 0.4 -0.3 -0.5 -0.5 -0.1 -0.3 -0.3 -0.3
Financial situation satisfaction 0.5 0.6 2.2 -1.1 -0.0 -0.1 -0.0 -0.6 -1.2 -0.5 -1.4 -0.1 0.3 -0.8 1.5 -0.7 -0.3 -0.1 -0.1 0.4 -1.4 -0.3 -0.3 -1.2 0.0 -1.0 -0.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.8 0.6 -0.2 0.2 -0.6 0.5 0.3 1.4 0.6 1.7 -0.4 0.8 -1.0 1.2 -0.9 -0.0 -0.1 -0.3 0.4 0.3 0.2 0.3 0.2 0.5 0.2
Commuting to job workplace: Public transport 4.0 4.8 7.2 -2.6 2.2 -2.2 1.3 -2.6 -2.6 -1.9 -2.7 -1.6 2.3 -2.2 2.4 -0.6 0.6 2.2 2.2 2.1 -2.6 -2.3 -2.3 -2.3 -2.2 -2.5 -2.4
Eye problems/disorders: Glaucoma 0.5 0.6 1.9 0.4 -1.1 0.6 -0.5 0.7 0.5 -0.6 0.4 -1.4 -0.6 0.1 0.7 0.7 -0.6 -1.0 -1.0 -0.9 0.6 0.8 0.8 0.6 1.1 0.7 0.8
Medication: Blood pressure 0.4 0.7 1.3 0.7 -0.9 1.2 -0.1 0.5 0.8 1.1 0.7 0.6 -0.9 1.0 -1.1 -0.8 -0.8 -1.0 -0.9 -1.0 0.9 0.8 0.9 0.7 0.9 0.9 0.9
Pain type(s) experienced in last month: Hip pain 1.5 1.9 4.7 1.3 -1.1 1.3 -2.1 2.2 1.3 1.4 1.2 1.3 -1.1 1.1 -1.3 2.0 -0.4 -1.1 -1.0 -1.2 1.7 1.1 1.2 1.6 1.1 1.3 1.2
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.5 1.2 -1.0 -0.6 -0.6 0.4 0.9 1.6 1.2 0.9 -1.1 0.9 -1.0 1.1 -0.9 -0.9 -1.0 -1.1 1.0 0.9 1.1 1.1 1.0 1.1 0.9
High cholesterol (Self-reported) 0.4 0.8 1.6 0.8 -0.8 0.9 -0.9 1.2 0.8 1.1 0.7 0.4 -0.9 1.0 -0.7 0.6 -0.4 -0.8 -0.9 -1.1 1.1 0.9 0.9 1.0 0.9 1.0 1.0
Medication: Bendroflumethiazide 0.9 1.3 3.4 1.4 -1.3 0.2 0.4 0.6 0.9 0.8 1.5 0.6 -1.3 1.2 -1.9 -1.7 -1.0 -1.3 -1.3 -1.0 0.8 1.2 1.3 0.9 1.3 1.1 1.1
Medication: Paracetamol 5.1 7.9 17.1 3.2 -2.3 2.1 -3.0 2.8 2.7 4.1 3.1 2.2 -2.8 3.2 -2.9 3.7 -1.4 -2.3 -2.3 -2.6 3.1 2.5 2.6 3.0 2.3 3.0 2.7
Medication: Lisinopril 0.3 0.3 1.8 0.4 0.9 -0.6 1.0 -0.4 0.3 -0.2 0.6 0.0 0.2 0.3 -0.5 -0.0 1.3 0.9 0.8 0.3 0.4 -0.3 -0.4 0.1 -0.8 0.1 -0.3
Medication: Atorvastatin 0.4 0.4 3.0 -0.1 -0.7 0.1 0.2 0.1 0.9 0.2 -0.2 0.7 -0.3 -0.1 -0.2 -1.7 -0.7 -0.8 -0.6 -0.6 1.1 0.7 0.6 0.6 0.7 0.5 0.8
Illnesses of father: High blood pressure 0.3 0.4 3.6 -0.4 0.5 0.0 0.9 -0.9 -0.0 -1.3 -0.4 -0.4 0.2 0.2 0.6 -1.9 0.6 0.3 0.4 0.3 -0.2 -0.3 -0.3 -0.3 -0.4 -0.3 -0.3
Alcohol drinker status: Never 0.3 0.4 2.1 0.2 -0.9 -0.2 -0.4 0.3 0.3 -0.2 0.3 0.5 -0.5 0.0 -0.1 0.3 -1.4 -1.0 -0.9 -0.7 0.4 0.7 0.6 0.2 0.9 0.4 0.5
Ever smoked 2.7 4.8 8.9 -2.5 2.3 -3.0 1.3 -1.9 -2.3 -1.8 -2.5 -0.1 2.4 -2.4 1.7 0.2 1.7 2.1 2.3 2.3 -2.4 -2.4 -2.4 -2.4 -2.3 -2.6 -2.5
Basal metabolic rate 0.0 0.1 0.4 0.1 0.0 0.4 0.1 0.4 -0.3 -0.6 0.1 0.3 -0.1 0.2 -0.3 -0.3 0.6 -0.1 0.0 0.1 -0.2 -0.0 0.1 -0.2 0.0 -0.1 -0.0
Leg fat percentage (left) 0.2 0.8 2.0 0.5 -1.1 0.8 -1.2 1.4 0.5 0.8 0.3 1.3 -0.9 0.8 -0.7 0.1 -0.3 -1.2 -1.1 -0.9 0.4 1.0 1.0 0.5 1.2 0.7 0.9
Arm fat-free mass (left) 0.0 0.1 1.1 -0.2 -0.2 0.5 0.2 0.5 -0.3 -0.3 -0.2 1.0 -0.1 -0.0 -0.5 -0.6 0.3 -0.3 -0.2 0.0 -0.2 0.1 0.1 -0.3 0.3 -0.2 0.0
Number of operations (self-reported) 0.3 0.5 2.9 -0.1 0.8 -1.1 1.7 -1.2 -0.6 -0.4 -0.0 -1.0 0.5 -0.3 0.4 -0.1 0.9 0.8 0.7 0.5 -0.3 -0.7 -0.5 -0.4 -0.7 -0.4 -0.5
Average weekly beer plus cider intake 2.4 3.4 6.4 2.4 -1.4 2.5 -1.8 1.9 2.0 1.3 2.2 1.5 -1.9 2.0 -2.5 2.1 -0.9 -1.4 -1.4 -1.6 1.9 1.6 1.8 1.9 1.4 1.9 1.8
Irritability 0.1 0.2 1.7 -0.1 -0.2 0.7 0.8 -0.2 0.2 -0.5 -0.2 0.7 -0.2 0.3 0.2 -1.3 -0.5 -0.2 -0.1 -0.1 0.3 0.1 0.1 0.1 0.1 0.0 0.1
Risk taking 1.1 1.7 3.9 1.2 -1.2 0.9 -1.7 1.6 1.5 0.4 1.2 2.0 -1.3 1.3 -1.1 0.2 -0.9 -1.2 -1.2 -1.3 1.6 1.4 1.3 1.4 1.3 1.4 1.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 6.9 1.2 -0.3 0.0 -1.2 0.4 0.6 0.7 1.3 -0.8 -0.6 1.1 -0.5 2.6 -0.2 -0.1 -0.2 -0.5 0.6 0.4 0.4 0.7 0.2 0.9 0.5
Fractured/broken bones in last 5 years 1.9 2.4 3.5 -1.7 1.6 -0.9 1.8 -1.5 -1.8 -0.7 -1.7 0.5 1.7 -1.3 1.4 -1.9 1.5 1.5 1.6 1.8 -1.4 -1.8 -1.7 -1.7 -1.6 -1.7 -1.7
Age started oral contraceptive pill 4.2 5.3 9.7 -2.7 1.9 -1.8 2.6 -3.0 -2.8 -1.2 -2.7 -0.9 2.3 -2.5 2.1 -2.6 0.2 1.8 1.9 2.4 -3.1 -2.2 -2.2 -2.8 -1.9 -2.8 -2.3
Diastolic blood pressure, automated reading 0.3 0.9 3.2 1.3 -0.2 0.9 1.2 -0.2 1.0 1.5 1.4 1.3 -0.9 1.2 -1.8 0.6 0.0 0.0 -0.2 -0.6 0.9 0.5 0.6 0.9 0.2 0.9 0.6
Ever depressed for a whole week 0.4 0.5 3.8 -0.5 -0.5 0.0 -0.4 0.0 -0.7 0.3 -0.8 0.6 -0.2 -0.0 1.8 -1.9 -1.0 -0.5 -0.5 -0.1 -1.1 0.2 0.1 -0.7 0.5 -0.4 -0.1
Unable to work because of sickness or disability 0.2 0.3 1.3 0.7 -0.0 0.6 -0.3 0.0 0.3 1.1 0.9 1.2 -0.1 0.6 -1.0 -0.2 -0.4 -0.0 0.0 -0.1 0.4 0.1 0.1 0.5 0.0 0.4 0.2
Commuting to job workplace: Cycle 3.0 3.7 6.8 -2.2 1.7 -2.3 1.6 -1.7 -1.9 -2.6 -2.2 1.4 2.2 -2.5 0.9 -2.4 1.7 1.6 1.7 1.8 -1.5 -1.9 -1.9 -1.6 -1.7 -2.0 -1.8
Myopia 0.2 0.3 4.0 0.4 -0.1 -0.4 0.4 0.2 0.3 0.9 0.7 -2.0 -0.1 -0.1 0.4 -0.1 0.3 -0.1 -0.0 -0.1 0.0 0.1 0.1 0.2 0.0 0.1 0.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 5.8 -0.5 0.3 -0.2 -1.9 0.4 -0.4 -0.8 -0.5 -0.5 0.5 -0.5 1.0 2.4 -0.1 0.3 0.3 0.4 -0.7 -0.3 -0.4 -0.4 -0.4 -0.4 -0.4
Cholesterol lowering medication 0.4 0.6 1.5 -0.8 1.0 0.5 0.8 -1.1 -0.4 0.3 -1.0 -1.2 0.6 -0.1 1.1 0.1 0.7 0.9 0.9 0.7 -0.5 -0.9 -0.8 -0.7 -1.0 -0.7 -0.8
Medication: Omeprazole (e.g. Zanprol) 3.3 4.0 6.4 1.9 -2.1 1.9 -2.5 2.2 2.0 1.5 1.8 1.2 -2.0 1.8 -2.0 -0.6 -1.6 -2.2 -2.2 -2.2 2.2 2.2 2.1 2.2 2.1 2.1 2.3
Pain experienced in last month 3.7 6.2 14.9 -2.4 2.2 -3.1 3.7 -3.3 -2.3 -1.6 -2.2 -1.5 2.2 -2.1 2.2 -3.9 1.2 2.0 2.2 2.5 -3.0 -2.3 -2.2 -2.8 -2.2 -2.6 -2.4
Supplements: Calcium 0.7 0.7 1.8 -1.2 0.3 -1.4 1.0 -0.4 -1.2 -1.1 -1.1 0.1 0.8 -1.1 0.7 -0.9 -0.5 0.5 0.3 0.6 -1.2 -0.6 -0.7 -1.1 -0.2 -1.0 -0.7
Basal cell carcinoma (self-reported) 0.4 0.4 2.1 0.5 -0.2 1.4 -0.6 1.0 0.4 0.4 0.2 0.5 -0.5 0.8 0.7 1.5 -0.1 -0.3 -0.2 -0.6 0.6 0.3 0.3 0.8 0.2 0.6 0.5
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.2 -1.0 -0.2 -1.3 1.0 -0.3 -0.6 -0.0 -1.2 -1.4 0.2 -0.7 1.5 -0.8 -0.5 -0.2 -0.2 0.3 -1.2 -0.1 -0.1 -0.9 0.2 -0.8 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 1.0 -0.2 0.3 0.3 0.2 0.3 -0.3 -0.4 -0.2 -0.1 0.3 -0.3 1.0 -0.2 0.5 0.2 0.3 0.2 0.3 -0.3 -0.4 0.1 -0.4 -0.1 -0.3
Heart disease (siblings) 0.3 0.3 1.0 0.1 -1.0 0.7 -0.5 0.5 0.2 0.0 -0.1 0.3 -0.7 0.6 -0.1 0.1 -0.7 -0.9 -1.0 -0.7 0.1 0.7 0.7 0.3 0.9 0.4 0.6
Alcohol drinker status: Previous 2.3 2.6 6.8 1.8 -1.6 1.5 -1.6 1.1 1.7 2.2 1.4 -0.6 -2.1 2.6 -0.8 0.1 -1.4 -1.6 -1.6 -1.6 1.3 1.7 1.8 1.6 1.6 1.8 1.6
Pack years of smoking 5.3 7.7 12.2 -2.5 3.4 -2.7 3.1 -3.4 -2.9 -1.4 -2.5 -0.9 2.8 -2.2 1.5 -0.8 2.1 3.5 3.4 3.4 -2.7 -3.2 -3.3 -2.9 -3.4 -2.9 -3.2
Impedance of whole body 1.9 9.5 19.2 2.8 -3.1 2.0 -4.4 3.1 3.4 3.5 2.5 0.8 -3.0 2.8 -2.2 4.3 -2.7 -3.0 -3.1 -3.3 3.1 3.2 3.2 3.2 3.1 3.2 3.2
Leg fat mass (left) 0.1 0.5 1.7 0.5 -0.9 0.7 -0.9 1.2 0.2 0.4 0.4 1.3 -0.7 0.7 -0.6 -0.2 0.0 -1.0 -0.9 -0.7 0.2 0.8 0.8 0.3 0.9 0.5 0.7
Arm predicted mass (left) 0.0 0.1 0.8 -0.2 -0.2 0.6 0.1 0.5 -0.3 -0.4 -0.2 0.9 -0.1 0.0 -0.5 -0.7 0.5 -0.3 -0.2 0.0 -0.2 0.1 0.1 -0.3 0.2 -0.1 0.0